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Mengmeng Sun, Eduard Van Wijk, Slavik Koval, Roeland Van Wijk, Min He, Mei Wang, Thomas Hankemeier, Jan van der Greef
The global prevalence of type 2 diabetes is estimated to reach 4.4% by 2030, placing a significant burden on our healthcare system. Therefore, the ability to identify patients in early stages of the disease is essential for both prevention and effective management, and diagnostic methods based on traditional Chinese medicine (TCM) may be suitable for identifying patients with early-stage type 2 diabetes. Here, a panel of three physicians trained in TCM classified 44 pre-diabetic subjects into three syndrome subtypes using TCM-based diagnostics...
November 17, 2016: Journal of Photochemistry and Photobiology. B, Biology
Rosilene Cristina Rossetto Burgos, Kateřina Červinková, Tom van der Laan, Rawi Ramautar, Eduard P A van Wijk, Michal Cifra, Slavik Koval, Ruud Berger, Thomas Hankemeier, Jan van der Greef
Ultra-weak photon emission (UPE) is light emitted spontaneously by biological systems without the use of specific luminescent complexes. UPE is emitted in the near-UV/UV-Vis/near-IR spectra during oxidative metabolic reactions; however, the specific pathways involved in UPE remain poorly understood. Here, we used HL-60 cells, a human promyelocytic cell line that is often used to study respiratory burst, as a model system to measure UPE kinetics together with metabolic changes. HL-60 cells were differentiated into neutrophil-like cells by culturing in all-trans-retinoic acid for 7days...
October 2016: Journal of Photochemistry and Photobiology. B, Biology
Emmanuel Moss, Michael E Halkos, Jose N Binongo, Douglas A Murphy
BACKGROUND: Unilateral pulmonary edema (UPE) has been reported after mitral operations performed through the right side of the chest. The clinical presentation is compatible with an ischemia-reperfusion injury. This report describes modifications to robotic mitral valve operations that were designed to reduce UPE. METHODS: We reviewed 15 patients with UPE after robotic mitral valve operations from 2006 through 2012. Technique modifications to reduce right lung ischemia were used from 2013 through June 2015...
August 17, 2016: Annals of Thoracic Surgery
Xin Zhao, Eduard van Wijk, Yu Yan, Roeland van Wijk, Huanming Yang, Yan Zhang, Jian Wang
Aging has been one of the several topics intensely investigated during recent decades. More scientists have been scrutinizing mechanisms behind the human aging process. Ultra-weak photon emission is known as one type of spontaneous photon emission that can be detected with a highly sensitive single photon counting photomultiplier tube (PMT) from the surface of human bodies. It may reflect the body's oxidative damage. Our aim was to examine whether ultra-weak photon emission from a human hand is able to predict one's chronological age...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
Zoé van Dyck, Beate M Herbert, Christian Happ, Gillian V Kleveman, Claus Vögele
Intuitive eating has been described to represent an adaptive eating behaviour that is characterised by eating in response to physiological hunger and satiety cues, rather than situational and emotional stimuli. The Intuitive Eating Scale-2 (IES-2) has been developed to measure such attitudes and behaviours on four subscales: unconditional permission to eat (UPE), eating for physical rather than emotional reasons (EPR), reliance on internal hunger and satiety cues (RHSC), and body-food choice congruence (B-FCC)...
October 1, 2016: Appetite
Steven Footitt, Simonetta Palleschi, Eugenio Fazio, Raffaele Palomba, William E Finch-Savage, Leopoldo Silvestroni
Seeds beneath the soil sense the changing environment to time germination and seedling emergence with the optimum time of year for survival. Environmental signals first impact with the seed at the seed coat. To investigate whether seed coats have a role in environmental sensing we investigated their ultraweak photon emission (UPE) under the variable temperature, relative humidity and oxygen conditions they could experience in the soil seed bank. Using a custom-built luminometer we measured UPE intensity and spectra (300-700 nm) from Phaseolus vulgaris seeds, seed coats and cotyledons...
September 2016: Photochemistry and Photobiology
Heungsup Sung, Dongeun Yong, Chang Seok Ki, Jae Seok Kim, Moon Woo Seong, Hyukmin Lee, Mi Na Kim
BACKGROUND: Real-time reverse transcription PCR (rRT-PCR) of sputum samples is commonly used to diagnose Middle East respiratory syndrome coronavirus (MERS-CoV) infection. Owing to the difficulty of extracting RNA from sputum containing mucus, sputum homogenization is desirable prior to nucleic acid isolation. We determined optimal homogenization methods for isolating viral nucleic acids from sputum. METHODS: We evaluated the following three sputum-homogenization methods: proteinase K and DNase I (PK-DNase) treatment, phosphate-buffered saline (PBS) treatment, and N-acetyl-L-cysteine and sodium citrate (NALC) treatment...
September 2016: Annals of Laboratory Medicine
Mi Na Kim, Young Jin Ko, Moon Woo Seong, Jae Seok Kim, Bo Moon Shin, Heungsup Sung
BACKGROUND: During the 2015 outbreak of Middle East Respiratory Syndrome coronavirus (MERS-CoV), six different commercial MERS-CoV RNA detection kits based on real-time reverse-transcription polymerase chain reaction (rRT-PCR) were available in Korea. We performed analytical and clinical validations of these kits. METHODS: PowerChek (Kogene Biotech, Korea), DiaPlexQ (SolGent, Korea), Anyplex (Seegene, Korea), AccuPower (Bioneer, Korea), LightMix (Roche Molecular Diagnostics, Switzerland), and UltraFast kits (Nanobiosys, Korea) were evaluated...
September 2016: Annals of Laboratory Medicine
Neda Rafieiolhosseini, Michaela Poplová, Pezhman Sasanpour, Hashem Rafii-Tabar, Mahsa Rafiee Alhossaini, Michal Cifra
Ultra-weak photon emission (UPE) is an endogenous bioluminescence phenomenon present in all biological samples with an active oxidative metabolism, even without an external pre-illumination. To verify the potential of UPE for non-invasive monitoring of metabolism and growth in germinating plants, the aim of this study was to investigate the UPE from a model system - germinating mung bean seedlings (Vigna radiata) - and analyze the statistical properties of UPE during the growth in two different conditions of imbibition (pure water and 1% sucrose)...
September 2016: Journal of Photochemistry and Photobiology. B, Biology
Daisaku Ando, Gen Yasuda
BACKGROUND: Proteinuria and nighttime blood pressure (BP) elevation are notable risk markers of chronic kidney disease and correlate closely with each other. However, daily urinary protein excretion (UPE) always fluctuates. In patients with minimal change nephrotic syndrome (MCNS), serum albumin concentrations (SAC) decrease but fluctuate less than UPE. We evaluated whether SAC is a reliable marker for proteinuria, and compared the relations among circadian BP changes, SAC, and UPE. METHODS: In patients with MCNS (12 men and 11 women, 43 ± 18 years), blood and spot urine samples were collected on three consecutive days before treatment, and 24-hour BP was also measured on the three days...
May 2016: Cardiorenal Medicine
Sameera Al Johani, Ali H Hajeer
Diagnosis of MERS-Cov still a major concern in most of daignostic laboratories. To date the Real-time Polymerase Chain reaction (RT-PCR) is the mainstay for diagnosis of MERS-CoV. RT-PCR has limitations, including a long turnaround time and lack of common measurements and correlations with Viral Load (VL). It is recommended to screen for MERS-CoV using RT-PCR of the upstream of envelope gene (upE) followed by confirmation of the presence of one of the following genes; open reading frame 1A, 1B genes or nucleocapsid (N) gene...
May 2016: Journal of Infection and Public Health
Masaki Kobayashi, Torai Iwasa, Mika Tada
Ultra-weak photon emission (UPE), often designated as biophoton emission, is generally observed in a wide range of living organisms, including human beings. This phenomenon is closely associated with reactive oxygen species (ROS) generated during normal metabolic processes and pathological states induced by oxidative stress. Application of UPE extracting the pathophysiological information has long been anticipated because of its potential non-invasiveness, facilitating its diagnostic use. Nevertheless, its weak intensity and UPE mechanism complexity hinder its use for practical applications...
June 2016: Journal of Photochemistry and Photobiology. B, Biology
Min He, Mengmeng Sun, Eduard van Wijk, Herman van Wietmarschen, Roeland van Wijk, Zhihong Wang, Mei Wang, Thomas Hankemeier, Jan van der Greef
To present the possibilities pertaining to linking ultra-weak photon emission (UPE) with Chinese medicine-based diagnostics principles, we conducted a review of Chinese literature regarding UPE with respect to a systems view of diagnostics. Data were summarized from human clinical studies and animal models published from 1979 through 1998. The research fields can be categorized as follows: (1) human physiological states measured using UPE; (2) characteristics of human UPE in relation to various pathological states; and (3) the relationship between diagnosis (e...
April 2016: Complementary Therapies in Medicine
Yan-Feng Zhao, Li Zhu, Li-Jun Liu, Su-Fang Shi, Ji-Cheng Lv, Hong Zhang
BACKGROUND AND OBJECTIVES: Proteinuria is an independent predictor for IgA nephropathy (IgAN) progression. Urine albumin-to-creatinine ratio (ACR), protein-to-creatinine ratio, and 24-hour urine protein excretion (UPE) are widely used for proteinuria evaluation in clinical practice. Here, we evaluated the association of these measurements with clinical and histologic findings of IgAN and explored which was the best predictor of IgAN prognosis. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients with IgAN were followed up for ≥12 months, were diagnosed between 2003 and 2012, and had urine samples available (438 patients)...
June 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Vahid Salari, Felix Scholkmann, Istvan Bokkon, Farhad Shahbazi, Jack Tuszynski
For several decades the physical mechanism underlying discrete dark noise of photoreceptors in the eye has remained highly controversial and poorly understood. It is known that the Arrhenius equation, which is based on the Boltzmann distribution for thermal activation, can model only a part (e.g. half of the activation energy) of the retinal dark noise experimentally observed for vertebrate rod and cone pigments. Using the Hinshelwood distribution instead of the Boltzmann distribution in the Arrhenius equation has been proposed as a solution to the problem...
2016: PloS One
Moon Woo Seong, Seung Jun Lee, Sung Im Cho, Kyungphil Ko, Mi Na Kim, Heungsub Sung, Jae Seok Kim, Ji Soo Ahn, Byung Su Yu, Taek Soo Kim, Eui Chong Kim, Sung Sup Park
BACKGROUND: The largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection outside Middle East Asia in 2015 has necessitated the rapid expansion of laboratories that conduct MERS-CoV molecular testing in Korea, together with external quality assessment (EQA) to evaluate the assays used. METHODS: The EQA program consisted of two phases; self-validation and blind assessment. For the first EQA phase, in vitro transcribed upstream region of the envelope gene (upE) and the open reading frame (ORF)1a RNAs were used at a concentration of 1,000 copies/μL...
May 2016: Annals of Laboratory Medicine
Yusuke Okabayashi, Nobuo Tsuboi, Kotaro Haruhara, Go Kanzaki, Kentaro Koike, Akihiro Shimizu, Yoichi Miyazaki, Iwao Ohno, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo
BACKGROUND: The number of elderly patients with IgA nephropathy (IgAN) is increasing in parallel with the increased longevity in the general population. However, information is limited regarding the characteristics of such patients. METHODS: IgAN patients who were ≥60 years of age at diagnosis were retrospectively analyzed. The clinicopathological features at biopsy, therapies during the follow-up period, renal outcomes and extrarenal complications were evaluated...
December 2016: Clinical and Experimental Nephrology
L-P da Silva, M-S Serpa, J-R Tenório, G-J-F do Nascimento, E-S de Souza-Andrade, A-P Veras-Sobral
BACKGROUND: Odontogenic tumors (OTs) are considered important among oral lesions because of their clinicopathological heterogeneity, and variable biological behavior. This paper aims to determine the frequency and distribution of OTs, over a period of 10 years, at a public university in Northeastern Brazil and compare this data with previous reports. MATERIAL AND METHODS: We reviewed all cases of OTs from oral pathology laboratory of University of Pernambuco (UPE), from 2004 to 2014...
May 1, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
Cristiano M Gallep, Peter W Barlow, Rosilene C R Burgos, Eduard P A van Wijk
In order to corroborate the hypothesis that variations in the rate of spontaneous ultra-weak photon emission (UPE) from germinating seedlings are related to local variations of the lunisolar tidal force, a series of simultaneous tests was performed using the time courses of UPE collected from three plant species-corn, wheat and sunflower-and also from wheat samples whose grains were transported between continents, from Brazil to The Netherlands and vice versa. All tests which were run in parallel showed coincident inflections within the UPE time courses not only between seedlings of the same species but also between the different species...
January 28, 2016: Protoplasma
Darko Ljubic, Chad S Smithson, Yiliang Wu, Shiping Zhu
The influence of polymer binders on the UV response of organic thin-film phototransistors (OTF-PTs) is reported. The active channel of the OTF-PTs was fabricated by blending a UV responsive 2,7-dipenty-[1]benzothieno[2,3-b][1]benzothiophene (C5-BTBT) as small molecule semiconductor and a branched unsaturated polyester (B-upe) as dielectric binder (ratio 1:1). To understand the influence of the polymer composition on the photoelectrical properties and UV response of C5-BTBT, control blends were prepared using common dielectric polymers, namely, poly(vinyl acetate) (PVAc), polycarbonate (PC), and polystyrene (PS), for comparison...
February 17, 2016: ACS Applied Materials & Interfaces
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