Moritz Schmelzle, Christian Benzing, Lutz Fischer, Uta Herden, Martina Sterneck, Utz Settmacher, Astrid Bauschke, Ulf Neumann, Uwe Pelzer, Tobias Müller, Christian Strassburg, Hauke Lang, Thomas Becker, Alfred Königsrainer, Silvio Nadalin, Markus Quante, Andreas Paul, Helmut Friess, Jürgen Klempnauer, Nicolas Richter, Florian Vondran, Andreas Pascher, Thomas Rösch, Wenzel Schöning, Felix Krenzien, Robert Öllinger, Daniel Seehofer, Peter Neuhaus, Johann Pratschke
Background: Liver transplantation (LT) is considered a therapeutic option for unresectable perihilar cholangiocarcinoma (PHC) within defined criteria. It remains uncertain whether patients can safely receive adjuvant chemotherapy after LT. Methods: We performed a prospective, multi-center, randomized, non-blinded two-arm trial (pro-duct001). Patients after LT for unresectable PHC within defined criteria were randomized to adjuvant gemcitabine (LT-Gem group) and LT alone (LT alone group)...
2022: Frontiers in Oncology