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Klatskin tumor

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https://www.readbyqxmd.com/read/28405328/photodynamic-therapy-with-polyhematoporphyrin-for-malignant-biliary-obstruction-a-nationwide-retrospective-study-of-150-consecutive-applications
#1
Werner Dolak, Hubert Schwaighofer, Brigitte Hellmich, Bernhard Stadler, Georg Spaun, Wolfgang Plieschnegger, Arnold Hebenstreit, Jutta Weber-Eibel, Franz Siebert, Klaus Emmanuel, Peter Knoflach, Michael Gschwantler, Wolfgang Vogel, Michael Trauner, Andreas Püspök
BACKGROUND: Photodynamic therapy (PDT) is a palliative treatment for malignant biliary obstruction. OBJECTIVE: The objective of this article is to assess the feasibility and safety of this technique. METHODS: In this nationwide, retrospective study of prospectively collected clinical data, all patients treated with PDT using polyhematoporphyrin in Austria from March 2004 to May 2013 were included. Feasibility, adverse events, stent patency and mortality rates were investigated...
February 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28373474/evaluation-of-tumor-markers-and-their-impact-on-prognosis-in-gallbladder-bile-duct-and-cholangiocellular-carcinomas-a-pilot-study
#2
Vaclav Liska, Vladislav Treska, Tomas Skalicky, Jakub Fichtl, Jan Bruha, Ondrej Vycital, Ondrej Topolcan, Richard Palek, Jachym Rosendorf, Jiri Polivka, Lubos Holubec
BACKGROUND/AIM: The behavior of tumor markers in biliary tract malignancies is not well-known and has been scarcely studied. Such markers could play important roles in diagnostic and prognostic schemes as well as in decision-making about the best treatment strategies. This study analyzed the preoperative serum levels of conventional tumor markers (AFP, CEA, CA 19-9, CA 72-4), proliferative marker thymidine kinase (TK) and cytokeratins (TPA, TPS and CYFRA 21.1) in patients with gallbladder carcinoma, bile duct carcinoma (Klatskin) and cholangiocellular carcinoma, in relation to the patient prognosis...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28288474/cholangiocellular-carcinoma
#3
Arndt Vogel, Anna Saborowski
BACKGROUND: Cholangiocarcinomas (CCAs) are aggressive malignancies that display features of biliary differentiation. According to their anatomical location, CCAs are commonly classified as intrahepatic and extrahepatic tumors, the latter entity being further subdivided into perihilar CCAs, also termed as Klatskin tumors, and distal tumors. While a majority of CCAs occur sporadically, established risk factors such as liver fluke infestation or primary sclerosing cholangitis exist. SUMMARY: Due to lack of efficient early screening markers, CCAs are frequently diagnosed at an advanced stage when curative surgical resection is not an option...
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28178122/mortality-after-portal-vein-embolization-two-case-reports
#4
Eung Chang Lee, Sang-Jae Park, Sung-Sik Han, Hyeong Min Park, Seung Duk Lee, Seong Hoon Kim, In Joon Lee, Hyun Beom Kim
Portal vein embolization (PVE) is increasingly performed worldwide to reduce the possibility of liver failure after extended hepatectomy, by inducing future liver remnant (FLR) hypertrophy and atrophy of the liver planned for resection. The procedure is known to be very safe and to have few procedure-related complications.In this study, we described 2 elderly patients with Bismuth-Corlette type IV Klatskin tumor who underwent right trisectional PVE involving the embolization of the right portal vein, the left medial sectional portal branch, and caudate portal vein...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27902955/extrahepatic-biliary-obstrution-secondary-to-neuroendocrine-tumor-of-the-common-hepatic-duct
#5
Faraz A Khan, Anastasia Stevens-Chase, Rahman Chaudhry, Asra Hashmi, David Edelman, Donald Weaver
INTRODUCTION: Primary neuroendocrine tumors (NET) of the extrahepatic biliary tree are a rare entity with less than 100 reported cases in the literature. PRESENTATION OF CASE: Here, we report a case of NET of the extrahepatic bile duct in a 64-year-old male patient presenting with painless jaundice, direct hyperbilirubinemia, and mildly elevated transaminases. Diagnostic workup with an ultrasound revealed dilation of the intrahepatic biliary ducts, without cholelithiasis or choledocholithiasis...
November 23, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27843427/isolated-liver-hilar-infiltration-by-igg4-inflammation-mimicking-cholangiocarcinoma
#6
Laurent Bochatay, Pietro Majno, Emiliano Giostra, Jean Louis Frossard
IgG4-related disease represents a heterogeneous group of disease characterized by infiltration of various tissues by IgG4 plasmocytes. In case of liver infiltration, this condition classically mimics primary sclerosing cholangitis or multifocal cholangiocarcinoma due to inflammation that preferentially affects the intra- and extrahepatic bile duct. Diagnostic criteria have recently been reviewed in order to better define the disease and help physicians make the diagnosis. Herein, we present the case of a patient who died after liver surgery for suspected cholangiocarcinoma that finally turned out to be IgG4-associated liver disease, a condition being out of current consensual criteria...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27795771/-role-of-biliary-mri-in-etiological-diagnosis-of-cholestatic-icteruses-in-dakar
#7
Nfally Badji, Geraud Akpo, Hamidou Deme, Mouhamadou Hamine Toure, Mamadou Ly, Boucar Ndong, El Hadji Niang
Biliary MRI is a relatively new diagnostic test in the arsenal of exploration techniques in biliopancreatic pathology. This is a reproducible and reliable non invasive technique for direct visualization of biliary and pancreatic ducts. This study aims to evaluate the morphological features of major abnormalities and the role of biliary MRI in the etiological diagnosis of cholestatic icteruses. This is a retrospective study of 17 patients conducted in the Imaging Unit of the University Hospital of Fann and of the Principal hospital of Dakar over a period of 4 years and six months (January 2008 at July 2012)...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27761479/the-klatskin-tumor-that-wasn-t-an-unusual-presentation-of-sarcoidosis
#8
Priya D Farooq, Darryn R Potosky
We present the case of a patient who presented with signs and symptoms associated with a Klatskin tumor. After endoscopic retrograde cholangiopancreatography (ERCP) and biopsy, she was found instead to have granulomatous infiltration of the extrahepatic biliary tree consistent with biliary sarcoidosis. The patient was treated successfully with systemic corticosteroids and azathioprine. She later developed cutaneous, lymphatic, and pulmonary granulomatous disease. Isolated biliary disease is a rare initial presentation of systemic sarcoidosis...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/27723691/-percutaneous-cholangiostomy-for-portal-cholangiocarcinoma
#9
O I Okhotnikov, M V Yakovleva, V I Pakhomov
AIM: to analyze the efficacy of interventional methods in treatment of Klatskin tumor patients. MATERIAL AND METHODS: Treatment of 133 patients with Klatskin tumor for the period 2000-2015 was analyzed. Bismuth I type was revealed in 28 (21.1%) cases, type II  - in 45 (33.8%) cases, type III - in 51 (38.3%) cases, type IV - in 9 (6.8%) cases. All patients underwent sonofluoroscopy-assisted percutaneous transhepatic cholangiostomy using self-fixing Pig tail 8Fr drains at the first stage followed by externointernal drainage or antegrade biliary stenting...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27648091/y-configured-metallic-stent-combined-with-125-i-seed-strands-cavity-brachytherapy-for-a-patient-with-type-iv-klatskin-tumor
#10
Jiao Dechao, Xinwei Han, Wang Yanli, Li Zhen
We report a case in an inoperable patient with type IV Klatskin tumor treated by the use of a novel, two piece, Y-configured self-expandable metallic stent (SEMS) combined with two (125)I seed strands via bilateral approach. The placement of the Y-shaped SEMS was successful and resulted in adequate biliary drainage. After 2 months of intraluminal brachytherapy (ILBT), both (125)I seed strands and temporary drainage catheter were removed after patency of the expanded stents was confirmed by the cholangiogram...
August 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27586966/a-pilot-study-of-concurrent-chemoradiotherapy-with-gemcitabine-and-cisplatin-in-patients-with-locally-advanced-biliary-tract-cancer
#11
Kyong Joo Lee, Seung Woo Yi, Jihye Cha, Jinsil Seong, Seungmin Bang, Si Young Song, Hee Man Kim, Seung Woo Park
PURPOSE: Combination chemotherapy with gemcitabine and cisplatin is a standard treatment for patients with advanced biliary tract cancer. This study aimed to evaluate the efficacy and safety of gemcitabine- and cisplatin-based concurrent chemoradiotherapy in patients with unresectable biliary tract cancer. METHODS: Patients with pathologically proven, unresectable, non-metastatic biliary tract cancer were enrolled. Gemcitabine was administered intravenously at a dose of 1000 mg/m(2) on days 1, 8, and 15...
October 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27447008/-biomolecular-prognostic-factors-in-klatskin-tumor
#12
REVIEW
Yu O Zharikov, Yu A Kovalenko, A V Czhao
No abstract text is available yet for this article.
2016: Khirurgiia
https://www.readbyqxmd.com/read/27374219/endobronchial-watanabe-spigot-in-the-treatment-of-bronchobiliary-fistula
#13
Cengiz Özdemir, Sinem Nedime Sökücü, Ayşegül Akbaş, Sezin Altay, Ahmet Levent Karasulu, Levent Dalar
Bronchobiliary fistula (BBF) is a rare condition in which an abnormal communication exists between the bile ducts and the bronchial tree. Malignancy is the most common etiology of BBF, although many others are possible. A 74-year-old male patient with an inoperable Klatskin tumor presented with a complaint of yellow-green sputum and cough; the patient underwent fiber-optic bronchoscopy based on a preliminary diagnosis of bronchobiliary fistula. Using fiber-optic rigid bronchoscopy, the laterobasal segment of the lower right lung lobe was occluded using three pieces of 5-mm Endobronchial Watanabe Spigot...
2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27373472/-operation-treatment-method-of-bismuth-corlette-%C3%A2-%C3%A2-hilar-cholangiocarcinoma
#14
Z Lu, D D Wang
Hilar cholangiocarcinoma (HCCA) is also known as cancer at the upper part of bile duct, perihilar cholangiocarcinoma or Klatskin tumor, etc.Bismuth-Corlette type Ⅲ hilar cholangiocarcinoma refers to tumor invading right hepatic duct (Ⅲa) or left hepatic duct (Ⅲb). While Bismuth-Corlette type Ⅳ hilar cholangiocarcinoma refers to both left and right intrahepatic bile ducts being invaded. Under the premise of strictly grasping the indications of surgery, if preoperative management is conducted carefully, extended hepatic resection is a safe and feasible surgery to remove Bismuth-Corlette type Ⅲ and type Ⅳ hilar cholangiocarcinoma...
July 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27366305/atypical-presentation-of-a-hepatic-artery-pseudoaneurysm-a-case-report-and-review-of-the-literature
#15
Casey M Luckhurst, Chelsey Perez, Amy L Collinsworth, Jose G Trevino
Classically, hepatic artery pseudoaneurysms (HAPs) arise secondary to trauma or iatrogenic causes. With an increasing prevalence of laparoscopic procedures of the hepatobiliary system the risk of inadvertent injury to arterial vessels is increased. Pseudoaneurysm formation post injury can lead to serious consequences of rupture and subsequent hemorrhage, therefore intervention in all identified visceral pseudoaneurysms has been advocated. A variety of interventional methods have been proposed, with surgical management becoming the last step intervention when minimally invasive therapies have failed...
June 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27120733/the-largest-western-experience-with-hepatopancreatoduodenectomy-lessons-learned-with-35-cases
#16
MULTICENTER STUDY
Eduardo de Souza Martins Fernandes, Felipe Tavares de Mello, Joaquim Ribeiro-Filho, Asterio Pinto do Monte-Filho, Moacir Martins Fernandes, Romulo Juventino Coelho, Monique Couto Matos, Antonio Augusto Peixoto de Souza, Orlando Jorge Martins Torres
BACKGROUND: Hepatopancreatoduodenectomy is one of the most complex abdominal operations mainly indicated in advanced biliary carcinoma. AIM: To present 10-year experience performing this operation in advanced malignant tumors. METHODS: This is a retrospective descriptive study. From 2004 to 2014, 35 hepatopancreatoduodenectomies were performed in three different institutions. The most common indication was advanced biliary carcinoma in 24 patients (68...
March 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27092322/stent-placement-above-the-sphincter-of-oddi-permits-implementation-of-neoadjuvant-chemotherapy-in-patients-with-initially-unresectable-klatskin-tumor
#17
Kensuke Kubota, Sho Hasegawa, Akito Iwasaki, Takamitsu Sato, Yuji Fujita, Kunihiro Hosono, Atsushi Nakajima, Ryutaro Mori, Ryusei Matsuyama, Itaru Endo
BACKGROUND AND STUDY AIMS: Neoadjuvant chemotherapy (NAC) may lead to a successful margin-negative resection in patients with initially unresectable locally advanced Klatskin tumor (IULAKT). Use of removable plastic stents is preferable for the safe implementation of NAC in patients with IULAKT to reduce the risk of recurrent cholangitis. Our aim was to evaluate the efficacy associated with the use of plastic stents placed across the stenosis and above the papilla (above stent) during NAC...
April 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27090415/-klatskin-tumor-long-term-survival-following-surgery
#18
B Juntermanns, C D Fingas, G C Sotiropoulos, D Jaradat, A Dechêne, H Reis, S Kasper, A Paul, G M Kaiser
BACKGROUND: Perihilar cholangiocarcinoma (Klatskin tumor) is a rare tumor entity with an unfavorable prognosis despite optimal treatment. OBJECTIVES: The aim of the study is to investigate beneficial histopathological features and recommendations for surgery in perihilar cholangiocarcinoma to improve patients' long term survival. MATERIAL AND METHODS: 192 patients suffering from perihilar cholangiocarcinoma underwent attempted tumor resection between 1998 and 2008 at our clinic...
June 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/27035079/palliative-locoregional-treatment-for-unresectable-nonmetastatic-klatskin-tumor-percutaneous-transhepatic-biliary-drainage-combined-with-3-dimensional-conformal-radiotherapy
#19
Yanfeng Liu, Jingxian Sun, Dening Ma, Bin Jin, Zhenyu Shao, Jianbo Wang, Zongli Zhang
PURPOSE: This study aimed to identify the effect of percutaneous transhepatic biliary drainage (PTBD) combined with 3-dimensional conformal radiotherapy (3D-CRT) in comparison with PTBD therapy only on the treatment of unresectable Klatskin tumors (KTs). MATERIALS AND METHODS: Thirty-seven patients with unresectable KTs were included in the study. Twenty-six patients received PTBD and 3D-CRT successively, whereas the other 11 patients received PTBD only. Changes in the clinical symptoms after the PTBD treatment, the radiotherapy effect, and the survival time were recorded and analyzed...
July 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27034794/percutaneous-y-biliary-stent-placement-in-palliative-treatment-of-type-4-malignant-hilar-stricture
#20
Fabio Corvino, Luca Centore, Emilio Soreca, Antonio Corvino, Vincenzo Farbo, Alfonso Bencivenga
BACKGROUND: This study evaluated the technical and clinical efficacy of percutaneous bilateral biliary stent-in-stent (SIS) deployment technique with a "Y" configuration using open-cell-design stents in type 4 Klatskin tumor patients. METHODS: Retrospective evaluation ten patients with type IV Bismuth malignant hilar stricture (MHS) treated with percutaneous bilateral "Y" SIS deployment technique placement followed in our institution between March of 2012 and November of 2014...
April 2016: Journal of Gastrointestinal Oncology
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