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rifampin for meningitis

Christopher Vinnard, Liza King, Sonal Munsiff, Aldo Crossa, Kentaro Iwata, Jotam Pasipanodya, Douglas Proops, Shama Ahuja
BACKGROUND: Tuberculous meningitis (TBM) is the most devastating clinical presentation of infection with Mycobacterium tuberculosis; delayed initiation of effective antituberculosis therapy is associated with poor treatment outcomes. Our objective was to determine the relationship between drug resistance and 10-year mortality among patients with TBM. METHODS: We conducted a retrospective cohort study of 324 patients with culture-confirmed TBM, susceptibility results reported for isoniazid and rifampin, and initiation of at least 2 antituberculosis drugs, reported to the tuberculosis registry in New York City between 1 January 1992 and 31 December 2001...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
B J Metcalf, S Chochua, R E Gertz, Z Li, H Walker, T Tran, P A Hawkins, A Glennen, R Lynfield, Y Li, L McGee, B Beall
Our whole genome sequence (WGS) pipeline was assessed for accurate prediction of antimicrobial phenotypes. For 2316 invasive pneumococcal isolates recovered during 2015 we compared WGS pipeline data to broth dilution testing (BDT) for 18 antimicrobials. For 11 antimicrobials categorical discrepancies were assigned when WGS-predicted MICs and BDT MICs predicted different categorizations for susceptibility, intermediate resistance or resistance, ranging from 0.9% (tetracycline) to 2.9% (amoxicillin). For β-lactam antibiotics, the occurrence of at least four-fold differences in MIC ranged from 0...
December 2016: Clinical Microbiology and Infection
Z F Chen, H L Lao, X H Li, J Wang, Q Chen, Z X Wang, D C Wang
OBJECTIVE: To explore the application value of GeneXpert MTB/RIF for detection of extra-pulmonary tuberculosis and resistance to rifampin. METHODS: A total of 150 samples were collected, including 33 needle aspirates from lymphoid tuberculosis, 23 needle aspirates from spinal tuberculosis, 49 from tuberculous pleural effusions, 24 from cerebrospinal fluid of tuberculous cephalomeningitis, and 21 urinary sediment samples from renal tuberculosis. Smear microscopy, mycobacterium tuberculosis culture and the MTB/RIF method were used to examine these samples and their positive rates were compared...
July 2016: Chinese Journal of Tuberculosis and Respiratory Diseases
Martin J Boeree, Stephen H Gillespie, Michael Hoelscher
No abstract text is available yet for this article.
June 2, 2016: New England Journal of Medicine
Reinout van Crevel, Rovina Ruslami, Rob Aarnoutse
No abstract text is available yet for this article.
June 2, 2016: New England Journal of Medicine
A Dorothee Heemskerk, Nguyen D Bang, Guy E Thwaites
No abstract text is available yet for this article.
June 2, 2016: New England Journal of Medicine
Katharine E Stott, Bhagteshwar Singh, Mike B J Beadsworth, Kate Vaudrey, Saye H Khoo, Geraint Davies
It is not always possible to administer antituberculosis pharmacotherapy orally for reasons that may be a direct consequence of tuberculosis itself. To our knowledge, no published literature is available regarding antituberculosis drug absorption via feeding tube. We present the case of a patient with tuberculosis meningitis who required medication administration via percutaneous endoscopic jejunostomy (PEJ) tube. Blood samples were collected during the continuation phase of antituberculosis therapy, immediately before dose administration, and then at 1, 2, 4, and 6 hours after dose administration for quantification of serum rifampin concentrations...
April 2016: Pharmacotherapy
Justin A Wasko, James S Westholder, Pamala A Jacobson
Purpose Patients undergoing hematopoietic cell transplantation are treated with multiple medications, potentially complicated by drug-drug interactions. Drug interactions with sirolimus, voriconazole, and rifampin are particularly difficult because of the complex and simultaneous enzyme inhibition and induction mechanisms. We report a hematopoietic cell transplantation patient receiving sirolimus and voriconazole who was given rifampin while being treated for presumed methicillin-resistant Staphylococcus aureus meningitis...
January 2017: Journal of Oncology Pharmacy Practice
A Dorothee Heemskerk, Nguyen D Bang, Nguyen T H Mai, Tran T H Chau, Nguyen H Phu, Pham P Loc, Nguyen V V Chau, Tran T Hien, Nguyen H Dung, Nguyen T N Lan, Nguyen H Lan, Nguyen N Lan, Le T Phong, Nguyen N Vien, Nguyen Q Hien, Nguyen T B Yen, Dang T M Ha, Jeremy N Day, Maxine Caws, Laura Merson, Tran T V Thinh, Marcel Wolbers, Guy E Thwaites, Jeremy J Farrar
BACKGROUND: Tuberculous meningitis is often lethal. Early antituberculosis treatment and adjunctive treatment with glucocorticoids improve survival, but nearly one third of patients with the condition still die. We hypothesized that intensified antituberculosis treatment would enhance the killing of intracerebral Mycobacterium tuberculosis organisms and decrease the rate of death among patients. METHODS: We performed a randomized, double-blind, placebo-controlled trial involving human immunodeficiency virus (HIV)-infected adults and HIV-uninfected adults with a clinical diagnosis of tuberculous meningitis who were admitted to one of two Vietnamese hospitals...
January 14, 2016: New England Journal of Medicine
Brian H Harcourt, Raydel D Anderson, Henry M Wu, Amanda C Cohn, Jessica R MacNeil, Thomas H Taylor, Xin Wang, Thomas A Clark, Nancy E Messonnier, Leonard W Mayer
Background.  Antimicrobial treatment and chemoprophylaxis of patients and their close contacts is critical to reduce the morbidity and mortality and prevent secondary cases of meningococcal disease. Through the 1990's, the prevalence of antimicrobial resistance to commonly used antimicrobials among Neisseria meningitidis was low in the United States. Susceptibility testing was performed to ascertain whether the proportions of isolates with reduced susceptibility to antimicrobials commonly used for N meningitidis have increased since 2004 in the United States...
September 2015: Open Forum Infectious Diseases
Cédric Bretonnière, Mathieu Jozwiak, Christophe Girault, Pascal Beuret, Jean-Louis Trouillet, Nadia Anguel, Jocelyne Caillon, Gilles Potel, Daniel Villers, David Boutoille, Christophe Guitton
INTRODUCTION: Bacterial meningitis among critically ill adult patients remains associated with both high mortality and frequent, persistent disability. Vancomycin was added to treatment with a third-generation cephalosporin as recommended by French national guidelines. Because animal model studies had suggested interest in the use of rifampin for treatment of bacterial meningitis, and after the introduction of early corticosteroid therapy (in 2002), there was a trend toward increasing rifampin use for intensive care unit (ICU) patients...
2015: Critical Care: the Official Journal of the Critical Care Forum
R M Savic, R Ruslami, J E Hibma, A Hesseling, G Ramachandran, A R Ganiem, S Swaminathan, H McIlleron, A Gupta, K Thakur, R van Crevel, R Aarnoutse, K E Dooley
Pediatric tuberculous meningitis (TBM) is a highly morbid, often fatal disease. Standard treatment includes isoniazid, rifampin, pyrazinamide, and ethambutol. Current rifampin dosing achieves low cerebrospinal fluid (CSF) concentrations, and CSF penetration of ethambutol is poor. In adult trials, higher-dose rifampin and/or a fluoroquinolone reduced mortality and disability. To estimate optimal dosing of rifampin and levofloxacin for children, we compiled plasma and CSF pharmacokinetic (PK) and outcomes data from adult TBM trials plus plasma PK data from children...
December 2015: Clinical Pharmacology and Therapeutics
Krishnendu Chatterjee, Chiung Wen Kuo, Ann Chen, Peilin Chen
BACKGROUND: Rifampicin or rifampin (R) is a common drug used to treat inactive meningitis, cholestatic pruritus and tuberculosis (TB), and it is generally prescribed for long-term administration under regulated dosages. Constant monitoring of rifampicin is important for controlling the side effects and preventing overdose caused by chronic medication. In this study, we present an easy to use, effective and less costly method for detecting residual rifampicin in urine samples using protein (bovine serum albumin, BSA)-stabilized gold nanoclusters (BSA-Au NCs) adsorbed on a paper substrate in which the concentration of rifampicin in urine can be detected via fluorescence quenching...
2015: Journal of Nanobiotechnology
Nitin Nema, Abha Verma, Kuldeep Singh, Virendra Mehar
Paradoxical response to anti-tubercular drugs remains a diagnostic dilemma. In India where tuberculosis is quite prevalent, paradoxical response to anti-tubercular treatment (ATT) is either misdiagnosed or under-diagnosed. We report two cases of optochiasmatic arachnoiditis due to paradoxical response in children suffering from tuberculous meningitis. Visual acuity was recorded as no light perception in all eyes of both patients while they were taking 4-drug ATT (isoniazid, rifampicin, pyrazinamide and ethambutol)...
April 2014: Middle East African Journal of Ophthalmology
Katarzyna Guziejko, Piotr Czupryna, Anna Moniuszko, Sambor Grygorczuk, Maciej Kondrusik, Joanna Zajkowska, Sławomir Pancewicz
In this paper we present a case of a 58 years old male with a rare form of extrapulmonary tuberculosis--tuberculous meningitis (TBM). Tuberculous meningitis is usually caused by hematogenous spread of Mycobacterium from lungs. The TBM is a severe disease with high mortality. The symptoms usually increase gradually and in the course of the disease 3 clinical stages (prodromal phase, phase of neurological symptoms and phase of paresis) may be differentiated. Cerebrospinal fluid examination, chest x-ray and sputum culture are crucial for diagnosis of TBM...
2013: Przegla̧d Epidemiologiczny
A Sood, S Chauhan, L Chandel, S C Jaryal
Primary amoebic meningoencephalitis is a rare fatal meningitis caused by free living amoeba Naegleria fowleri, found in freshwater ponds and lakes. It infects children and young adults with exposure due to swimming or diving. We report a case of N. fowleri meningitis in a 6-year-old boy who presented with signs and symptoms of acute bacterial meningitis. No history of travelling or swimming was present. However, the boy frequently played with water stored from a "kuhl" (diversion channels of water). Wet mount of cerebrospinal fluid (CSF) revealed amoeboid and actively motile flagellate forms of trophozoites...
April 2014: Indian Journal of Medical Microbiology
Dong-Hyun Kim, Young Hwan Choi, Hyoung Sang Kim, Ji Eun Yu, Young-Il Koh
Rifampin is commonly used as a first-line anti-tuberculosis drug, but it can induce a serum sickness-like reaction or anaphylaxis. However, it is possible for 1 drug antigen to induce 2 or more simultaneous immunologic reactions. Here, we report a case of a serum-sickness-like reaction and anaphylaxis induced concurrently by rifampin. A 25-year-old male presented with high fever and a maculopapular rash with vesicles on the hands, which developed 2 weeks following regular administration of anti-tuberculosis drugs for tuberculous meningitis, including rifampin...
March 2014: Allergy, Asthma & Immunology Research
Güzin Cinel, Nural Kiper, Sevgi Pekcan, Mustafa Koyun, Mehmet Köse, Nazan Çobanoğlu, Ayşe Tana Aslan, Ebru Yalçın, Deniz Doğru, Uğur Özçelik, Ayhan Göçmen
INTRODUCTION: Tuberculosis is still a global health problem all over the world despite its mortality has been decreased with effective treatment regimens. Poor treatment adherence, acquired drug resistance, treatment failure and relapse are the major problems during the course of the tuberculosis treatment. Intermittent regimens have the advantages of reducing the side effects and the cost of the therapy and increasing the adherence, especially in resource-limited areas; and have been documented to be as effective as daily regimen in the paediatric population...
2013: Tüberküloz Ve Toraks
Nguyen Thi Quynh Nhu, Dorothee Heemskerk, Do Dang Anh Thu, Tran Thi Hong Chau, Nguyen Thi Hoang Mai, Ho Dang Trung Nghia, Pham Phu Loc, Dang Thi Minh Ha, Laura Merson, Tran Thi Van Thinh, Jeremy Day, Nguyen van Vinh Chau, Marcel Wolbers, Jeremy Farrar, Maxine Caws
Tuberculous meningitis (TBM) is the most severe form of tuberculosis. Microbiological confirmation is rare, and treatment is often delayed, increasing mortality and morbidity. The GeneXpert MTB/RIF test was evaluated in a large cohort of patients with suspected tuberculous meningitis. Three hundred seventy-nine patients presenting with suspected tuberculous meningitis to the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, between 17 April 2011 and 31 December 2012 were included in the study. Cerebrospinal fluid samples were tested by Ziehl-Neelsen smear, mycobacterial growth indicator tube (MGIT) culture, and Xpert MTB/RIF...
January 2014: Journal of Clinical Microbiology
J P Caire Estévez, S González-Ocampo Dorta, P Sanz Solana
CASE REPORT: The case is presented of a 29-year-old woman who complained of headache over a period of several days, with loss of visual acuity and pain in her left eye. She had a 3-year history of type 1 diabetes mellitus, and was an immigrant from Ecuador. The funduscopic examination revealed a papilledema. The polymerase chain reaction (PCR) study of the cerebrospinal fluid was positive for Mycobacterium tuberculosis (MTB). She showed a marked improvement after treatment with anti-TB drugs...
October 2013: Archivos de la Sociedad Española de Oftalmología
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