Amelie Paasche, Felix Wiedmann, Manuel Kraft, Fitzwilliam Seibertz, Valerie Herlt, Pablo L Blochberger, Natasa Jávorszky, Moritz Beck, Leo Weirauch, Timon Seeger, Antje Blank, Walter E Haefeli, Rawa Arif, Anna L Meyer, Gregor Warnecke, Matthias Karck, Niels Voigt, Norbert Frey, Constanze Schmidt
In recent years, SGLT2 inhibitors have become an integral part of heart failure therapy, and several mechanisms contributing to cardiorenal protection have been identified. In this study, we place special emphasis on the atria and investigate acute electrophysiological effects of dapagliflozin to assess the antiarrhythmic potential of SGLT2 inhibitors. Direct electrophysiological effects of dapagliflozin were investigated in patch clamp experiments on isolated atrial cardiomyocytes. Acute treatment with elevated-dose dapagliflozin caused a significant reduction of the action potential inducibility, the amplitude and maximum upstroke velocity...
February 2024: Basic Research in Cardiology