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https://www.readbyqxmd.com/read/29057883/non-muscular-myosin-light-chain-kinase-triggers-intermittent-hypoxia-induced-interleukin-6-release-endothelial-dysfunction-and-permeability
#1
Sylvain Recoquillon, Manuel Gómez-Guzmán, Marion Rodier, Camille Koffi, Mathieu Nitiéma, Frédéric Gagnadoux, M Carmen Martínez, Ramaroson Andriantsitohaina
Obstructive sleep apnea is characterized by intermittent hypoxia (IH) which alters endothelial function, induces inflammation and accelerates atherosclerosis-induced cardiovascular diseases. The non-muscular myosin light chain kinase (nmMLCK) isoform contributes to endothelial cell-cell junction opening. Deletion of nmMLCK protects mice from death in septic shock models and prevents atherosclerosis in high-fat diet-fed mice. The aim of the study was to analyze the implication of nmMLCK in IH-induced vascular inflammation...
October 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057457/differential-effects-of-selective-agonists-of-neuromedin-u1-and-2-receptors-in-obese-and-diabetic-mice
#2
Hiroaki Nagai, Tomoko Kaisho, Kotaro Yokoyama, Tomoko Asakawa, Hisashi Fujita, Kouta Matsumiya, Jiro Noguchi, Kazue Tsuchimori, Naoki Nishizawa, Yoko Kanematsu-Yamaki, Katsuko Dote, Hiroshi Inooka, Jun-Ichi Sakamoto, Tetsuya Ohtaki, Taiji Asami, Shiro Takekawa
BACKGROUND AND PURPOSE: Neuromedin U (NMU) may be a novel target for obesity treatment owing to its anorectic and energy expenditure enhancing effects. Although two receptors, NMU1 and NMU2, are both responsible for the NMU-mediated anti-obesity effects, the receptor agonist with the most appropriate profiles for treating obesity and diabetes in terms of efficacy and safety is as yet unknown. Thus, we developed and evaluated novel NMU1/2 receptor-selective agonists. EXPERIMENTAL APPROACH: Efficacy and safety were assessed in mice with diet-induced obesity (DIO) and those with leptin-deficient diabetes (ob/ob) through repeated peripheral administration of selective agonists to NMU1 (NMU-6102) and NMU2 (NMU-2084), along with NMU1/2 non-selective agonists (NMU-0002 and NMU-6014)...
October 22, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29056891/polygala-tenuifolia-extract-inhibits-lipid-accumulation-in-3t3-l1-adipocytes-and-high-fat-diet-induced-obese-mouse-model-and-affects-hepatic-transcriptome-and-gut-microbiota-profiles
#3
Chun-Chung Wang, Jui-Hung Yen, Yi-Cheng Cheng, Chia-Yu Lin, Cheng-Ta Hsieh, Rung-Jiun Gau, Shu-Jiau Chiou, Hwan-You Chang
Obesity, the excessive accumulation of lipids in the body, is closely associated with many prevalent human disorders. Continued efforts to identify plant extracts that exhibit anti-obesity effects have drawn much attention. This study investigated whether a Polygala tenuifolia extract (PTE) possesses anti-obesity activity and how PTE may affect liver gene expression and gut microbiota. We used 3T3-L1 adipocytes and a high-fat diet-induced obese mouse model to determine the effects of PTE on lipid accumulation...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29056887/dietary-coconut-water-vinegar-for-improvement-of-obesity-associated-inflammation-in-high-fat-diet-treated-mice
#4
Nurul Elyani Mohamad, Swee Keong Yeap, Huynh Ky, Wan Yong Ho, Sook Yee Boo, Joelle Chua, Boon-Kee Beh, Shaiful Adzni Sharifuddin, Kamariah Long, Noorjahan Banu Alitheen
Obesity has become a serious health problem worldwide. Various types of healthy food, including vinegar, have been proposed to manage obesity. However, different types of vinegar may have different bioactivities. This study was performed to evaluate the anti-obesity and anti-inflammatory effects of coconut water vinegar on high-fat-diet (HFD)-induced obese mice. Changes in the gut microbiota of the mice were also evaluated. To induce obesity, C57/BL mice were continuously fed an HFD for 33 weeks. Coconut water vinegar (0...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29056532/lamp3-regulates-hepatic-lipid-metabolism-through-activating-pi3k-akt-pathway
#5
REVIEW
Xiaoyu Liao, Lingyu Song, Linlin Zhang, Hui Wang, Qiang Tong, Jing Xu, Gangyi Yang, Shiming Yang, Hongting Zheng
Lysosome associated membrane protein 3 (LAMP3), a highly glycosylated protein, is one member of the LAMPs family. LAMPs family plays a critical role in the autolysosome fusion process. Autophagy was recently confirmed to regulate hepatic lipolysis. However, the physiological function of LAMP3 in lipid metabolism is not clear. In the current study, we discovered that the LAMP3 expression level was higher in the liver tissues of non-alcoholic fatty liver disease (NAFLD) patients and high-fat diet and ob/ob mice than in the matched control groups...
October 19, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29056530/the-effect-of-combined-diet-and-exercise-intervention-on-body-weight-and-the-serum-gpihbp1-concentration-in-overweight-obese-middle-aged-women
#6
Masashi Aruga, Yoshiharu Tokita, Katsuyuki Nakajima, Keiko Kamachi, Akira Tanaka
BACKGROUND: The relationship between the effects of diet and exercise intervention and the body weight associated with the serum lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1) concentrations has not been elucidated. METHODS: Sixty-six overweight/obese middle aged women were assigned to the diet and exercise intervention for 4months. They were divided into 2 groups followed by the body mass index (BMI) decreased >3% (n=41) and <3% (n=25)...
October 19, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29056104/a-maternal-high-fat-high-sucrose-diet-alters-insulin-sensitivity-and-expression-of-insulin-signalling-and-lipid-metabolism-genes-and-proteins-in-male-rat-offspring-effect-of-folic-acid-supplementation
#7
Candace E Cuthbert, Jerome E Foster, D Dan Ramdath
A maternal high-fat, high-sucrose (HFS) diet alters offspring glucose and lipid homoeostasis through unknown mechanisms and may be modulated by folic acid. We investigated the effect of a maternal HFS diet on glucose homoeostasis, expression of genes and proteins associated with insulin signalling and lipid metabolism and the effect of prenatal folic acid supplementation (HFS/F) in male rat offspring. Pregnant Sprague-Dawley rats were randomly fed control (CON), HFS or HFS/F diets. Offspring were weaned on CON; at postnatal day 70, fasting plasma insulin and glucose and liver and skeletal muscle gene and protein expression were measured...
October 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29055981/nutritional-values-and-metabolic-profile-with-and-without-boiled-treatment-of-gallo-matese-beans-phaseolus-vulgaris-l-a-landrace-from-southern-italy
#8
Nicola Landi, Sara Ragucci, Michelina Fiorentino, Vincenzo Guida, Antimo Di Maro
BACKGROUND: 'Gallo Matese' beans are known as a typical legume of Southern Italy and continue to be consumed as a traditional food preserving the diversity of this region. Nonetheless, no information about the nutritional values of this legume is available. The objective of the present investigation was to determine the nutritional value and metabolic profile of 'Gallo Matese' beans. Results. 'Gallo Matese' beans contain high levels of proteins (22.64 g/100 g) and essential amino acids  (8...
July 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29055952/aloe-emodin-relieves-high-fat-diet-induced-qt-prolongation-via-mir-1-inhibition-and-ik1-up-regulation-in-rats
#9
Yan Bai, Zhenli Su, Hanqi Sun, Wei Zhao, Xue Chen, Pengzhou Hang, Wenliang Zhu, Zhimin Du
BACKGROUND/AIMS: High-fat diet (HFD) causes cardiac electrical remodeling and increases the risk of ventricular arrhythmias. Aloe-emodin (AE) is an anthraquinone component isolated from rhubarb and has a similar chemical structure with emodin. The protective effect of emodin against cardiac diseases has been reported in the literature. However, the cardioprotective property of AE is still unknown. The present study investigated the effect of AE on HFD-induced QT prolongation in rats. METHODS: Adult male Wistar rats were randomly divided into three groups: control, HFD, and AE-treatment groups...
October 20, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29055549/short-communication-effect-of-replacing-corn-with-beet-pulp-in-a-high-concentrate-diet-fed-to-weaned-holstein-calves-on-diet-digestibility-and-growth
#10
T S Dennis, F X Suarez-Mena, T M Hill, J D Quigley, R L Schlotterbeck, G J Lascano
Using soluble fiber sources in starter and grower feeds for dairy calves less than 4 mo of age is common to reduce costs compared with including traditional cereal grains. Beet pulp (BP) contains relatively high concentrations of pectin compared with other fibrous feed ingredients and has been shown to be an acceptable replacement for corn in adult cow diets. However, limited information is available on BP digestibility and growth performance for young calves fed diets with BP. In this study, 48 male Holstein calves (59 ± 2 d of age, 77 ± 2...
October 18, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29054390/oral-pioglitazone-ameliorates-fructose-induced-peripheral-insulin-resistance-and-hippocampal-gliosis-but-not-restores-inhibited-hippocampal-adult-neurogenesis
#11
Wen-Chung Liu, Chih-Wei Wu, You-Lin Tain, Mu-Hui Fu, Chun-Ying Hung, I-Chun Chen, Lee-Wei Chen, Kay L H Wu
Diet-associated insulin resistance (IR) is intimately correlated to the progression of metabolic syndrome and hippocampal dysfunction. Pioglitazone (PIO), a selective peroxisome proliferator-activated receptor gamma (PPARγ) agonist, has been applied to enhance insulin sensitivity. With limited permeability to blood-brain-barrier, it is unclear that whether oral PIO available to cure both the peripheral IR and the impairment in hippocampus. We evaluated the levels of peripheral and hippocampal IR via the homeostatic model assessment of insulin resistance and hippocampal IRS-1/Akt phosphorylation, respectively, of Wistar Kyoto rats fed with regular chew or high fructose diet (HFD) for 12weeks...
October 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29053741/the-importance-of-propolis-in-alleviating-the-negative-physiological-effects-of-heat-stress-in-quail-chicks
#12
Gamal M K Mehaisen, Rania M Ibrahim, Adel A Desoky, Hosam M Safaa, Osama A El-Sayed, Ahmed O Abass
Heat stress is one of the most detrimental confrontations in tropical and subtropical regions of the world, causing considerable economic losses in poultry production. Propolis, a resinous product of worker honeybees, possesses several biological activities that could be used to alleviate the deleterious effects of high environmental temperature on poultry production. The current study was aimed at evaluating the effects of propolis supplementation to Japanese quail (Coturnix coturnix japonica) diets on the production performance, intestinal histomorphology, relative physiological and immunological parameters, and selected gene expression under heat stress conditions...
2017: PloS One
https://www.readbyqxmd.com/read/29053735/characterization-of-the-first-knock-out-aldh7a1-zebrafish-model-for-pyridoxine-dependent-epilepsy-using-crispr-cas9-technology
#13
Nikita Zabinyakov, Garrett Bullivant, Feng Cao, Matilde Fernandez Ojeda, Zheng Ping Jia, Xiao-Yan Wen, James J Dowling, Gajja S Salomons, Saadet Mercimek-Andrews
Pyridoxine dependent epilepsy (PDE) is caused by likely pathogenic variants in ALDH7A1 (PDE-ALDH7A1) and inherited autosomal recessively. Neurotoxic alpha-amino adipic semialdehyde (alpha-AASA), piperideine 6-carboxylate and pipecolic acid accumulate in body fluids. Neonatal or infantile onset seizures refractory to anti-epileptic medications are clinical features. Treatment with pyridoxine, arginine and lysine-restricted diet does not normalize neurodevelopmental outcome or accumulation of neurotoxic metabolites...
2017: PloS One
https://www.readbyqxmd.com/read/29053729/the-influence-of-the-selection-of-macronutrients-coupled-with-dietary-energy-density-on-the-performance-of-broiler-chickens
#14
Sonia Y Liu, Peter V Chrystal, Aaron J Cowieson, Ha H Truong, Amy F Moss, Peter H Selle
A total of 360 male Ross 308 broiler chickens were used in a feeding study to assess the influence of macronutrients and energy density on feed intakes from 10 to 31 days post-hatch. The study comprised ten dietary treatments from five dietary combinations and two feeding approaches: sequential and choice feeding. The study included eight experimental diets and each dietary combination was made from three experimental diets. Choice fed birds selected between three diets in separate feed trays at the same time; whereas the three diets were offered to sequentially fed birds on an alternate basis during the experimental period...
2017: PloS One
https://www.readbyqxmd.com/read/29052029/migration-and-invasion-induced-by-linoleic-acid-are-mediated-through-fascin-in-mda-mb-231-breast-cancer-cells
#15
Christian Gonzalez-Reyes, Cleofas Marcial-Medina, Nancy Cervantes-Anaya, Pedro Cortes-Reynosa, Eduardo Perez Salazar
Epidemiological studies strongly suggest an association between high levels of dietary fat intake and an increased risk of developing breast cancer. Linoleic acid (LA) is an essential omega-6 PUFA and the major fatty acid in occidental diets. In breast cancer cells, LA induces expression of plasminogen activator inhibitor-1, proliferation, migration, and invasion. Fascin is an actin crosslinker globular protein that generates actin bundles made of parallel actin filaments, which mediate formation and stability of microspikes, stress fibers, membrane ruffles, and filopodia...
October 19, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29050421/performance-nutrient-utilization-and-energy-partitioning-in-broiler-chickens-offered-high-canola-meal-diets-supplemented-with-multicomponent-carbohydrase-and-mono-component-protease
#16
M Toghyani, S B Wu, R A Pérez-Maldonado, P A Iji, R A Swick
Two broiler chicken experiments were conducted to investigate the effects of canola meal (CM) replacing soybean meal (SBM) in diets supplemented with carbohydrase and protease on performance and partitioning of energy. First, a 2 × 2 × 2 factorial arrangement of treatments was employed to evaluate: protein meals (CM vs. SBM), carbohydrase (none or 300 mg/kg), protease (none or 200 mg/kg), and their interactions. Each treatment was fed to 6 replicated pens of 16 male broilers (Ross 308) from d 10 to 35. In the second experiment, 32 broiler chicks were used in a 2 × 2 factorial arrangement to investigate CM and carbohydrase effects on energy partitioning...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050301/mir-377-promotes-white-adipose-tissue-inflammation-and-decreases-insulin-sensitivity-in-obesity-via-suppression-of-sirtuin-1-sirt1
#17
Jie Peng, Yinghui Wu, Zhao Deng, Yuanfei Zhou, Tongxing Song, Yang Yang, Xiaming Zhang, Tao Xu, Mao Xia, Anle Cai, Zuhong Liu, Jian Peng
Obesity is associated with a wide range of metabolic disorders including inflammation and insulin-resistance. Sirtuin-1 (SIRT1) is an important regulator of metabolic homeostasis and stress response pathways in white adipose tissue. However, involvement of microRNAs (miRNAs) in regulating SIRT1 during obesity-induced inflammation and insulin-resistance remains unclear. Here, we found that miR-377 was upregulated in adipose tissue and showed a negative correlation with SIRT1 in chronic high fat diet (HFD)-fed mice...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049383/lutein-accumulates-in-subcellular-membranes-of-brain-regions-in-adult-rhesus-macaques-relationship-to-dha-oxidation-products
#18
Emily S Mohn, John W Erdman, Matthew J Kuchan, Martha Neuringer, Elizabeth J Johnson
OBJECTIVES: Lutein, a carotenoid with anti-oxidant functions, preferentially accumulates in primate brain and is positively related to cognition in humans. Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid (PUFA), is also beneficial for cognition, but is susceptible to oxidation. The present study characterized the membrane distribution of lutein in brain regions important for different domains of cognitive function and determined whether membrane lutein was associated with brain PUFA oxidation...
2017: PloS One
https://www.readbyqxmd.com/read/29049335/structural-prediction-of-two-novel-human-atypical-slc-transporters-mfsd4a-and-mfsd9-and-their-neuroanatomical-distribution-in-mice
#19
Emelie Perland, Sofie Victoria Hellsten, Nadine Schweizer, Vasiliki Arapi, Fatemah Rezayee, Mona Bushra, Robert Fredriksson
Out of the 430 known solute carriers (SLC) in humans, 30% are still orphan transporters regarding structure, distribution or function. Approximately one third of all SLCs belong to the evolutionary conserved and functionally diverse Major Facilitator Superfamily (MFS). Here, we studied the orphan proteins, MFSD4A and MFSD9, which are atypical SLCs of MFS type. Hidden Markov Models were used to identify orthologues in several vertebrates, and human MFSD4A and MFSD9 share high sequence identity with their identified orthologues...
2017: PloS One
https://www.readbyqxmd.com/read/29046730/aliskiren-effect-on-non-alcoholic-steatohepatitis-in-metabolic-syndrome
#20
F N Ramalho, S C Sanches, M C Foss, M J Augusto, D M Silva, A M Oliveira, L N Ramalho
BACKGROUND: Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of aliskiren, a direct renin inhibitor, on metabolic syndrome-related NASH. METHODS: C57BL/6 male mice (n = 45) were divided into three groups: controls; animals inoculated with streptozotocin (STZ) (40 mg/kg/day) for 5 days and fed with high fat diet (HFD) for 8 weeks; and animals inoculated with STZ for 5 days, fed with HFD for 8 weeks and treated with aliskiren (100 mg/kg/day) for the final 2 weeks...
2017: Diabetology & Metabolic Syndrome
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