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https://www.readbyqxmd.com/read/29454073/the-accumulation-of-assembly-intermediates-of-the-mitochondrial-complex-i-matrix-arm-is-reduced-by-limiting-glucose-uptake-in-a-neuronal-like-model-of-melas-syndrome
#1
Guillaume Geffroy, Rayane Benyahia, Samuel Frey, Valerie Desquiret-Dumas, Naig Gueguen, Celine Bris, Sophie Belal, Aurore Inisan, Aurelie Renaud, Arnaud Chevrollier, Daniel Henrion, Dominique Bonneau, Franck Letournel, Guy Lenaers, Pascal Reynier, Vincent Procaccio
Ketogenic diet (KD) which combined carbohydrate restriction and the addition of ketone bodies has emerged as an alternative metabolic intervention used as an anticonvulsant therapy or to treat different types of neurological or mitochondrial disorders including MELAS syndrome. MELAS syndrome is a severe mitochondrial disease mainly due to the m.3243A > G mitochondrial DNA mutation. The broad success of KD is due to multiple beneficial mechanisms with distinct effects of very low carbohydrates and ketones...
February 14, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29453986/sterol-o-acyltransferase-1-deficiency-improves-defective-insulin-signaling-in-the-brains-of-mice-fed-a-high-fat-diet
#2
Ning Xu, Hao Meng, Tian-Yi Liu, Ying-Li Feng, Yuan Qi, Dong-Huan Zhang, Hong-Lei Wang
Insulin resistance induced by a high-fat diet (HFD) is related to metabolic diseases, and sterol O-acyltransferase 1 (SOAT1) is a key enzyme for the biosynthesis of cholesteryl ester. In the present study, wild-type (WT) mice and SOAT1-knockout (KO) mice with a C57BL6 background fed a HFD were used to explore the role of SOAT1 in the hypothalamus. The results show that the WT mice exhibited a significant increase in body weight as well as hepatic histologic changes; they also had a lower glucose and insulin tolerance than the WT mice fed a normal diet...
February 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29453556/effects-of-increasing-dietary-protein-supplies-on-milk-yield-milk-composition-and-nitrogen-use-efficiency-in-lactating-buffalo
#3
Muhammad Naveed-Ul-Haque, Muhammad Uzair Akhtar, Rizwan Munnawar, Saba Anwar, Anjum Khalique, Murtaza Ali Tipu, Fayyaz Ahmad, Muhammad Qamer Shahid
Nitrogen efficiency of lactating buffalo can be increased by providing dietary crude protein (CP) precisely to the requirement. Twelve lactating Nili-Ravi buffaloes (6 primiparous and 6 multiparous) at 76 ± 37.5 days in milk (DIM) were used in this study. The treatments were diets providing three levels of CP (% DM basis): (1) low-protein = 11%; (2) medium-protein = 13.1%; (3) high-protein = 14.2% according to a 3 × 3 Latin square design. The period length of each treatment was 21 days and the total duration of experiment was 63 days...
February 16, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29452386/amino-acid-digestibility-of-larval-meal-musca-domestica-for-broiler-chickens
#4
H N Hall, H V Masey O'Neill, D Scholey, E Burton, M Dickinson, E C Fitches
Work was undertaken to investigate the potential use of housefly (Musca domestica) larvae reared on broiler manure as a source of nutrition for poultry production in the United Kingdom. Nutritional analysis showed that larvae have a high (>45% dry wt.) protein content and a favorable amino acid profile that is rich in key amino acids, such as lysine and methionine. A broiler digestibility trial was carried out to determine the apparent ileal digestibility coefficients (AIDC) and true ileal digestibility coefficients (TIDC) of amino acids (AA) from insect larval meal (ILM) from M...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29449334/rgc-32-response-gene-to-complement-32-protein-deficiency-protects-endothelial-cells-from-inflammation-and-attenuates-atherosclerosis
#5
Xiao-Bing Cui, Jun-Na Luan, Kun Dong, Sisi Chen, Yongyi Wang, Wendy T Watford, Shi-You Chen
OBJECTIVE: The objective of this study is to determine the role and underlying mechanisms of RGC-32 (response gene to complement 32 protein) in atherogenesis. APPROACH AND RESULTS: RGC-32 was mainly expressed in endothelial cells of atherosclerotic lesions in both ApoE -/- (apolipoprotein E deficient) mice and human patients. RGC-32 deficiency (Rgc32 -/- ) attenuated the high-fat diet-induced and spontaneously developed atherosclerotic lesions in ApoE -/- mice without affecting serum cholesterol concentration...
February 15, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29446933/dietary-sodium-butyrate-supplementation-reduces-high-concentrate-diet-feeding-induced-apoptosis-in-mammary-cells-in-dairy-goats
#6
Guangjun Chang, Jinyu Yan, Nana Ma, Xinxin Liu, Hongyu Dai, Muhammad Shaid Bilal, Xiangzhen Shen
Eighteen lactating goats (38.86 ± 2.06 kg) were randomly allocated to three groups. One group was fed a low-concentrate (LC) diet (forage:concentrate = 6:4, LC), while the other two groups were fed a high-concentrate (HC) diet (forage:concentrate = 4:6, HC) or an HC diet supplemented with sodium butyrate (BHC) for 20 weeks. Samples of ruminal fluid, milk, hepatic blood plasma, and mammary gland tissue were prepared for the experimental analysis. The LPS concentration, caspase-3 and -8 enzymatic activity, caspase-3 and -8 mRNA expression, and NF-κB (p65), phosphorylated-p65, bax, cytochrome C, and caspase-3 protein expression were higher in the HC group than those in the LC group; however, the levels of these parameters were lower in the BHC group than those in the HC group...
February 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29446245/differential-metabolic-effects-of-constant-moderate-versus-high-intensity-interval-training-in-high-fat-fed-mice-possible-role-of-muscle-adiponectin
#7
Sergio F Martinez-Huenchullan, Babu Raja Maharjan, Paul F Williams, Charmaine S Tam, Susan V Mclennan, Stephen M Twigg
Exercise regimens may have differing effects in the presence of obesity. In addition to being fat derived, adiponectin has recently been described as a myokine that regulates insulin sensitivity, which may link to exercise-related metabolic benefits in obesity. Whether skeletal muscle adiponectin varies in different exercise modalities is unclear. This study investigated the comparative effects of 10 weeks of endurance constant-moderate intensity exercise (END) with high intensity interval training (HIIT), on metabolic outcomes, including muscle adiponectin in a mouse model of diet-induced obesity...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29445454/rumen-protected-methionine-during-the-peripartal-period-in-dairy-cows-and-its-effects-on-abundance-of-major-species-of-ruminal-bacteria
#8
Mohamed K Abdelmegeid, Ahmed A Elolimy, Zheng Zhou, Vincenzo Lopreiato, Joshua C McCann, Juan J Loor
Background: Extensive degradation of amino acids in the rumen via microbial deamination decreases the post-ruminal availability of dietary indispensable amino acids. Together with the normal decrease in voluntary dry matter intake (DMI) around parturition in dairy cows, microbial metabolism contributes to a markedly negative balance of indispensable amino acids, including methionine which may be the first-limiting for milk production. The main objective of the current study was to profile changes in major bacterial species with key functions in cellulose and hemicellulose digestion, xylan breakdown, proteolytic action, propionic acid production, lactate utilization and ruminal biohydrogenation in cows supplemented with rumen-protected Methionine (SM; Smartamine M, Adisseo NA, Alpharetta, GA, USA) from -23 through 30 d relative to parturition...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29445341/celastrol-alleviates-airway-hyperresponsiveness-and-inhibits-th17-responses-in-obese-asthmatic-mice
#9
Zeyu Zeng, Xixi Lin, Rongying Zheng, Hui Zhang, Weixi Zhang
Severe airway hyperresponsiveness (AHR) is a clinical feature of asthma, which has been associated with obesity and has shown a poor response to standard asthma treatments such as glucocorticoids. Numerous studies have shown that Interleukin (IL)-17 producing CD4 + T cells (Th17 cells), which could be inhibited by celastrol, is essential in mediating steroid-resistant AHR. The following study investigates the impact of celastrol and its mechanism on the regulation of AHR in murine model of obesity and asthma...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29445240/high-fat-diet-induced-metabolically-obese-and-normal-weight-rabbit-model-shows-early-vascular-dysfunction-mechanisms-involved
#10
Gabriela Alarcon, Julieta Roco, Mirta Medina, Analia Medina, Maria Peral, Susana Jerez
BACKGROUND: Obesity contributes significantly to the development and evolution of cardiovascular disease (CVD) which is believed to be mediated by oxidative stress, inflammation and endothelial dysfunction. However, the vascular health of metabolically obese and normal weight (MONW) individuals is not completely comprehended. OBJECTIVES: The purpose of our study was to evaluate vascular function on the basis of a high fat diet (HFD)-MONW rabbit model. SUBJECTS: Twenty four male rabbits were randomly assigned to receive either a regular diet (CD, n = 12) or a high-fat diet (18% extra fat on the regular diet, HFD, n = 12) for 6 weeks...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29444163/the-effect-of-nutramiltm-complex-food-for-special-medical-purpose-on-breast-and-prostate-carcinoma-cells
#11
Aneta A Koronowicz, Mariola Drozdowska, Barbara Wielgos, Ewelina Piasna-Słupecka, Dominik Domagała, Joanna Dulińska-Litewka, Teresa Leszczyńska
NutramilTM Complex is a multicomponent food product that meets the requirements of a food for special medical purpose. As a complete, high-energy diet it consists of properly balanced nutrients, vitamins and minerals. The aim of this study was to assess the effect of NutramilTM Complex on breast and prostate carcinoma cells. Our results showed that NutramilTM Complex reduced the viability and proliferation of breast and prostate cancer cells and that this process was associated with the induction of apoptosis via activation of caspase signalling...
2018: PloS One
https://www.readbyqxmd.com/read/29444098/integrating-nutrient-bioavailability-and-co-production-links-when-identifying-sustainable-diets-how-low-should-we-reduce-meat-consumption
#12
Tangui Barré, Marlène Perignon, Rozenn Gazan, Florent Vieux, Valérie Micard, Marie-Josèphe Amiot, Nicole Darmon
BACKGROUND: Reducing the consumption of meat and other animal-based products is widely advocated to improve the sustainability of diets in high-income countries. However, such reduction may impair nutritional adequacy, since the bioavailability of key nutrients is higher when they come from animal- vs plant-based foods. Meat reduction may also affect the balance between foods co-produced within the same animal production system. OBJECTIVE: The objective was to assess the impact of introducing nutrient bioavailability and co-production links considerations on the dietary changes needed - especially regarding meat ‒ to improve diet sustainability...
2018: PloS One
https://www.readbyqxmd.com/read/29442728/inhibition-of-p53-relieves-insulin-resistance-in-fetal-growth-restriction-mice-with-catch-up-growth-via-activating-igfbp3-igf-1-irs-1-akt-signaling-pathway
#13
Ping Peng, Chunling Ma, Shumei Wan, Wensheng Jin, Yan Gao, Tianqing Huang, Qi Cheng, Changlan Ye
To investigate insulin resistance of the fetal growth restriction (FGR) mice with catch-up growth (CUG) and the underlying mechanism, in this study, low protein diet was used during pregnancy to establish the FGR mice model, and high fat diet was applied to establish the CUG model of FGR mice. The insulin and Pifithrin-α stimulation was performed via intraperitoneal injection. The physical characters, biochemical parameters, expression of related molecules in each group were detected via ELISA, RT-PCR, WB, etc...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439931/does-low-protein-diet-influence-the-uremic-toxin-serum-levels-from-the-gut-microbiota-in-nondialysis-chronic-kidney-disease-patients
#14
Ana Paula Black, Juliana S Anjos, Ludmila Cardozo, Flávia L Carmo, Carla J Dolenga, Lia S Nakao, Dennis de Carvalho Ferreira, Alexandre Rosado, José Carlos Carraro Eduardo, Denise Mafra
OBJECTIVES: To evaluate the effects of low-protein diet (LPD) on uremic toxins and the gut microbiota profile in nondialysis chronic kidney disease (CKD) patients. DESIGN AND METHODS: Longitudinal study with 30 nondialysis CKD patients (stage 3-4) undergoing LPD for 6 months. Adherence to the diet was evaluated based on the calculation of protein equivalent of nitrogen appearance from the 24-hour urine analysis. Good adherence to LPD was considered when protein intake was from 90% to 110% of the prescribed amount (0...
February 10, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29439404/high-fat-diet-induced-obesity-produces-spontaneous-ventricular-arrhythmias-and-increases-the-activity-of-ryanodine-receptors-in-mice
#15
Gina Sánchez, Felipe Araneda, Juan Pedro Peña, José Pablo Finkelstein, Jaime A Riquelme, Luis Montecinos, Genaro Barrientos, Paola Llanos, Zully Pedrozo, Matilde Said, Ricardo Bull, Paulina Donoso
Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, can produce ventricular arrhythmias. Since obesity promotes oxidative stress and RyR2 are redox-sensitive channels, we investigated whether the RyR2 activity was altered in obese mice. Mice fed a high fat diet (HFD) became obese after eight weeks and exhibited a significant increase in the occurrence of ventricular arrhythmias...
February 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29439004/assessing-the-nutrient-intake-of-a-low-carbohydrate-high-fat-lchf-diet-a-hypothetical-case-study-design
#16
Caryn Zinn, Amy Rush, Rebecca Johnson
OBJECTIVE: The low-carbohydrate, high-fat (LCHF) diet is becoming increasingly employed in clinical dietetic practice as a means to manage many health-related conditions. Yet, it continues to remain contentious in nutrition circles due to a belief that the diet is devoid of nutrients and concern around its saturated fat content. This work aimed to assess the micronutrient intake of the LCHF diet under two conditions of saturated fat thresholds. DESIGN: In this descriptive study, two LCHF meal plans were designed for two hypothetical cases representing the average Australian male and female weight-stable adult...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438776/quercetin-ameliorates-hfd-induced-nafld-by-promoting-hepatic-vldl-assembly-and-lipophagy-via-the-ire1a-xbp1s-pathway
#17
Xinhong Zhu, Ting Xiong, Peiyi Liu, Xiaoping Guo, Lin Xiao, Feng Zhou, Yuhan Tang, Ping Yao
The consumption of a quercetin-rich diet has been well-established as a feasible method against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms underlying the progression of NAFLD and its intervention by quercetin remain largely obscure. Male Sprague-Dawley rats fed high-fat diet (HFD), and HepG2 cells stimulated with free fatty acid, were treated with quercetin and various pharmacological reagents to explore the effect of signaling pathways involved in endoplasmic reticulum stress on very low-density lipoprotein (VLDL) assembly and lipophagy...
February 10, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29438418/bile-acid-detoxifying-enzymes-limit-susceptibility-to-liver-fibrosis-in-female-shrsp5-dmcr-rats-fed-with-a-high-fat-cholesterol-diet
#18
Husna Yetti, Hisao Naito, Yuan Yuan, Xiaofang Jia, Yumi Hayashi, Hazuki Tamada, Kazuya Kitamori, Katsumi Ikeda, Yukio Yamori, Tamie Nakajima
During middle age, women are less susceptible to nonalcoholic steatohepatitis (NASH) than men. Thus, we investigated the underlying molecular mechanisms behind these sexual differences using an established rat model of NASH. Mature female and male stroke-prone spontaneously hypertensive 5/Dmcr rats were fed control or high-fat-cholesterol (HFC) diets for 2, 8, and 14 weeks. Although HFC-induced hepatic fibrosis was markedly less severe in females than in males, only minor gender differences were observed in expression levels of cytochrome P450 enzymes (CYP)7A1, CYP8B1 CYP27A1, and CYP7B1, and multidrug resistance-associated protein 3, and bile salt export pump, which are involved in fibrosis-related bile acid (BA) kinetics...
2018: PloS One
https://www.readbyqxmd.com/read/29436695/inhibition-of-mammalian-target-of-rapamycin-complex-1-signaling-by-n-3-polyunsaturated-fatty-acids-promotes-locomotor-recovery-after-spinal-cord-injury
#19
Jiping Nie, Jian Chen, Jianguo Yang, Qinqin Pei, Jing Li, Jia Liu, Lixin Xu, Nan Li, Youhao Chen, Xiaohua Chen, Hao Luo, Tiansheng Sun
The present study aimed to explore the effects of n‑3 polyunsaturated fatty acids (PUFAs) on autophagy and their potential for promoting locomotor recovery after spinal cord injury (SCI). Primary neurons were isolated and cultured. Sprague‑Dawley rats were randomly divided into three groups and fed diets with different amounts of n‑3 PUFAs. A model of spinal cord contusion was created at the T10 spinal segment and the composition of PUFAs was analyzed using gas chromatography. Spinal repair and motor function were evaluated postoperatively...
February 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29434819/tangshen-formula-improves-inflammation-in-renal-tissue-of-diabetic-nephropathy-through-sirt1-nf-%C3%AE%C2%BAb-pathway
#20
Yue-Guang Du, Ke-Na Zhang, Zong-Lei Gao, Fengjiao Dai, Xi-Xi Wu, Ke-Fu Chai
The present study investigated the mechanism underlying the anti-inflammatory effects of Tangshen formula (TS) in Sprague Dawley (SD) rats with diabetic nephropathy (DN). A rat model of DN was established by intraperitoneal injection of 1% (40 mg/kg) streptozotocin and administration of a high fat and glucose diet. Subsequently, SD rats were randomly divided into six groups (n=8): A DN group, a valsartan group, a high-dose TS group, a middle-dose TS group, a low-dose TS group and a control group with normal SD rats...
February 2018: Experimental and Therapeutic Medicine
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