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https://www.readbyqxmd.com/read/28429928/a-dual-enzyme-hydrogen-peroxide-generation-machinery-in-hydrogels-supports-antimicrobial-wound-treatment
#1
Daniela Huber, Gregor Tegl, Anna Mensah, Bianca Beer, Martina Baumann, Nicole Borth, Christoph Sygmund, Roland Ludwig, Georg M Guebitz
The aging population and accompanying diseases like diabetes resulted in an increased occurrence of chronic wounds. Topical wound treatment with antimicrobial agents to inhibit bacterial invasion and promote wound healing is often associated with difficulties. Here, we investigated the potential of succinyl chitosan (SC) - carboxymethyl cellulose (CMC) hydrogels which constantly release clinically relevant levels of hydrogen peroxide (H2O2). CMC hydrogel matrix was in-situ converted by limited hydrolysis by a cellulase into substrates accepted by cellobiose dehydrogenase (CDH) for continuous production of H2O2 (30 µM over 24 h)...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28421715/effect-of-water-bath-temperature-on-physiological-parameters-and-subjective-sensation-in-older-people
#2
Junji Ono, Nobuko Hashiguchi, Hiroyuki Sawatari, Tomoko Ohkusa, Mami Miyazono, Su-Young Son, Chie Magota, Yutaka Tochihara, Akiko Chishaki
AIM: In Japan, the incidence of water bathing-related cardiopulmonary accidents among older people is high in winter. The purpose of the present study was to investigate alterations in physiological characteristics and subjective thermal sensations of older people when bathing in a cool environment. METHODS: We assessed the skin temperature, rectal temperature, blood pressure, pulse rate, body fluid loss (sweat and urine), and subjective thermal responses of 11 older healthy male and 10 young male volunteers throughout 42°C and 39°C bathing in a room at 20°C with 50% humidity...
April 19, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28419830/creative-cognition-and-dopaminergic-modulation-of-fronto-striatal-networks-integrative-review-and-research-agenda
#3
REVIEW
Nathalie Boot, Matthijs Baas, Simon van Gaal, Roshan Cools, Carsten K W De Dreu
Creative cognition is key to human functioning yet the underlying neurobiological mechanisms are sparsely addressed and poorly understood. Here we address the possibility that creative cognition is a function of dopaminergic modulation in fronto-striatal brain circuitries. It is proposed that (i) creative cognition benefits from both flexible and persistent processing, (ii) striatal dopamine and the integrity of the nigrostriatal dopaminergic pathway is associated with flexible processing, while (iii) prefrontal dopamine and the integrity of the mesocortical dopaminergic pathway is associated with persistent processing...
April 15, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28417966/the-ecdysis-triggering-hormone-system-is-essential-for-successful-moulting-of-a-major-hemimetabolous-pest-insect-schistocerca-gregaria
#4
Cynthia Lenaerts, Dorien Cools, Rik Verdonck, Lina Verbakel, Jozef Vanden Broeck, Elisabeth Marchal
Insects are enclosed in a rigid exoskeleton, providing protection from desiccation and mechanical injury. To allow growth, this armour needs to be replaced regularly in a process called moulting. Moulting entails the production of a new exoskeleton and shedding of the old one and is induced by a pulse in ecdysteroids, which activates a peptide-mediated signalling cascade. In Holometabola, ecdysis triggering hormone (ETH) is the key factor in this cascade. Very little functional information is available in Hemimetabola, which display a different kind of development characterized by gradual changes...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416654/reconstructed-ancestral-enzymes-suggest-long-term-cooling-of-earth-s-photic-zone-since-the-archean
#5
Amanda K Garcia, J William Schopf, Shin-Ichi Yokobori, Satoshi Akanuma, Akihiko Yamagishi
Paleotemperatures inferred from the isotopic compositions (δ(18)O and δ(30)Si) of marine cherts suggest that Earth's oceans cooled from 70 ± 15 °C in the Archean to the present ∼15 °C. This interpretation, however, has been subject to question due to uncertainties regarding oceanic isotopic compositions, diagenetic or metamorphic resetting of the isotopic record, and depositional environments. Analyses of the thermostability of reconstructed ancestral enzymes provide an independent method by which to assess the temperature history inferred from the isotopic evidence...
April 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28416597/posterior-inferotemporal-cortex-cells-use-multiple-input-pathways-for-shape-encoding
#6
Carlos R Ponce, Stephen G Lomber, Margaret S Livingstone
In the macaque monkey brain, posterior inferior temporal cortex (PIT) cells contribute to visual object recognition. They receive concurrent inputs from visual areas V4, V3 and V2. We asked how these different anatomical pathways shape PIT response properties by deactivating them while monitoring PIT activity in two male macaques. We found that cooling of V4 or V2|3 did not lead to consistent changes in population excitatory drive, however, population pattern analyses showed that V4-based pathways were more important than V2|3-based pathways...
April 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28411743/psychophysiological-responses-to-short-term-cooling-during-a-simulated-monotonous-driving-task
#7
Elisabeth Schmidt, Ralf Decke, Ralph Rasshofer, Angelika C Bullinger
For drivers on monotonous routes, cognitive fatigue causes discomfort and poses an important risk for traffic safety. Countermeasures against this type of fatigue are required and thermal stimulation is one intervention method. Surprisingly, there are hardly studies available to measure the effect of cooling while driving. Hence, to better understand the effect of short-term cooling on the perceived sleepiness of car drivers, a driving simulator study (n = 34) was conducted in which physiological and vehicular data during cooling and control conditions were compared...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28411724/thermal-comfort-of-seats-as-visualized-by-infrared-thermography
#8
Rosemary Bom Conselho Sales, Romeu Rodrigues Pereira, Maria Teresa Paulino Aguilar, Antônio Valadão Cardoso
Published studies that deal with the question of how the temperature of chair seats influences human activities are few, but the studies considering such a factor, a function of the type of material, could contribute to improvements in the design of chairs. This study evaluates seat temperatures of 8 types of chairs made of different materials. The parts of the furniture that people come into contact with, and the thermal response of the material to heating and cooling have been evaluated. Infrared thermography was used for this, as it is a non-contact technique that does not present any type of risk in the measurement of temperatures...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28411103/-endogenous-regeneration-engineering-growth-factors-for-stroke
#9
REVIEW
Su Jing Chan, Christopher Love, Myron Spector, Simon M Cool, Victor Nurcombe, Eng H Lo
Despite the efforts in developing therapeutics for stroke, recombinant tissue plasminogen activator (rtPA) remains the only FDA approved drug for ischemic stroke. Regenerative medicine targeting endogenous growth factors has drawn much interest in the clinical field as it provides potential restoration for the damaged brain tissue without being limited by a narrow therapeutic window. To date, most of the translational studies using regenerative medicines have encountered problems and failures. In this review, we discuss the effects of some trophic factors which include of erythropoietin (EPO), brain derived neurotrophic factor (BDNF), granulocyte-colony stimulating factor (G-CSF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), epidermal growth factor (EGF) and heparin binding epidermal growth factor (HB-EGF) in experimental ischemic stroke models and elaborate the lost in translation of the candidate growth factors from bench to bedside...
April 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28409944/coherent-atom-phonon-interaction-through-mode-field-coupling-in-hybrid-optomechanical-systems
#10
Michele Cotrufo, Andrea Fiore, Ewold Verhagen
We propose a novel type of optomechanical coupling which enables a tripartite interaction between a quantum emitter, an optical mode, and a macroscopic mechanical oscillator. The interaction uses a mechanism we term mode field coupling: a mechanical displacement modifies the spatial distribution of the optical mode field, which, in turn, modulates the emitter-photon coupling rate. In properly designed multimode optomechanical systems, we can achieve situations in which mode field coupling is the only possible interaction pathway for the system...
March 31, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28404580/effects-of-face-head-and-whole-body-cooling-during-passive-heat-stress-on-human-somatosensory-processing
#11
Hiroki Nakata, Mari Namba, Ryusuke Kakigi, Manabu Shibasaki
We herein investigated the effects of face/head and whole body cooling during passive heat stress on human somatosensory processing recorded by somatosensory-evoked potentials (SEPs) at C4' and Fz electrodes. Fourteen healthy subjects received a median nerve stimulation at the left wrist. SEPs were recorded at normothermic baseline (Rest), when esophageal temperature had increased by ~1.2 °C (Heat stress: HS) during passive heating, face/head cooling during passive heating (face/head cooling: FHC), and after HS (whole body cooling: WBC)...
April 12, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28403609/solid-state-nmr-characterization-of-ibuprofen-nicotinamide-cocrystals-and-new-idea-for-controlling-release-of-drugs-embedded-into-mesoporous-silica-particles
#12
Ewa Skorupska, Sławomir Kaźmierski, Marek J Potrzebowski
Grinding and melting methods were employed for synthesis of pharmaceutical cocrystals formed by racemic (R/S) and entiomeric (S) ibuprofen (IBU) and nicotinamide (NA) as coformer. Obtained (R/S)-IBU:NA and (S)-IBU:NA cocrystals were fully characterized by means of advanced one- and two-dimensional solid state nuclear magnetic resonance (SS NMR) techniques with very fast magic angle spinning (MAS) at 60 kHz. The distinction in molecular packing and specific hydrogen bonding pattern was clearly recognized by analysis of (1)H, (13)C, and (15)N spectra...
April 18, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28401532/gram-positive-pneumonia-augments-non-small-cell-lung-cancer-metastasis-via-host-toll-like-receptor-2-activation
#13
Stephen D Gowing, Simon C Chow, Jonathan J Cools-Lartigue, Crystal B Chen, Sara Najmeh, Henry Y Jiang, France Bourdeau, Annie Beauchamp, Ugo Mancini, Isabelle Angers, Betty Giannias, Jonathan D Spicer, Simon Rousseau, Salman T Qureshi, Lorenzo E Ferri
Surgical resection of early stage non-small cell lung cancer (NSCLC) is necessary for cure. However, rates of post-operative bacterial pneumonias remain high and may confer an increased risk for metastasis. Toll-like receptors (TLRs) mediate the inflammatory cascade by recognizing microbial products at the surface of numerous cell types in the lung; however, little is known about how host TLRs influence NSCLC metastasis. TLR2 recognizes gram-positive bacterial cell wall components activating innate immunity...
April 12, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28399621/aerobic-synergized-exercises-may-improve-fall-related-physical-fitness-in-older-adults
#14
Yu-Chen Chang, Jung-Der Wang, Ho-Cheng Chen, Susan C Hu
BACKGROUND: The purpose of the present study was to determine whether a synergistic exercise model based on aerobics with additional fall-preventive components could provide extra benefits compared with the same duration of aerobic-synergistic exercise alone. METHODS: A total of 102 adults aged 65 years and over from three geographically separated communities were assigned to three groups: the general aerobic exercise (GAE) group (N.=44), the GAE plus ball game group (BG group; N...
May 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28399285/hovering-and-swarming-behavior-of-male-tabanus-calens-diptera-tabanidae-in-tennessee-and-new-jersey-usa
#15
Bradley A Mullens, Jeffrey V Freeman
Hovering and swarming activity of male Tabanus calens L. were documented at distinctive sites above a woodland road clearing in Knox Co., TN (7 d), and above a slow-flowing river in Morris Co., NJ (6 d). Activity was restricted to the period near sunset. Mean activity typically began about 10 min before sunset and continued until about 10 min after sunset, with an average duration of 18.7 min (Tennessee) and 20.8 min (New Jersey). Swarming began earlier and thus lasted longer (55 min) on one cool New Jersey date...
April 1, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28397896/tailored-microstructure-of-colloidal-lipid-particles-for-pickering-emulsions-with-tunable-properties
#16
Anja Schröder, Joris Sprakel, Karin Schroën, Claire C Berton-Carabin
Sub-micron colloidal lipid particles (CLPs) can successfully be used as Pickering stabilizers in oil-in-water (O/W) emulsions, leading to an enhanced physical stability compared to conventional emulsifier-stabilized emulsions. Varying the lipid solid-liquid ratio leads to particles with distinct nanostructure and morphology, resulting in tunable emulsion stabilization performance. Our CLPs are produced by hot high pressure homogenization of high melting point fats in water, and subsequent cooling to induce lipid crystallization...
April 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/28397598/anhydrobiosis-affects-thermal-habituation-in-the-bdelloid-rotifer-adineta-sp
#17
Mai Kanazawa, Takahiro Nanri, Masayuki Saigusa
The bdelloid rotifer of the genus Adineta is a freshwater metazoan characterized by anhydrobiosis, a highly stable state of suspended animation induced by desiccation. This study investigated the influence of anhydrobiosis on the thermal habituation by use of an index, Activity Ratio (AR = the number of active rotifers at each experimental temperature/ number of active rotifers at the 25°C stage). In the first experiment, rotifers were divided into two groups: one group was cultivated at 25°C throughout experiment, and another group was transferred to 15°C for two days...
April 2017: Zoological Science
https://www.readbyqxmd.com/read/28396253/moderate-therapeutic-hypothermia-induces-multimodal-protective-effects-in-oxygen-glucose-deprivation-reperfusion-injured-cardiomyocytes
#18
Jana Krech, Giang Tong, Sylvia Wowro, Christoph Walker, Lisa-Maria Rosenthal, Felix Berger, Katharina Rose Luise Schmitt
OBJECTIVE: Therapeutic hypothermia has been shown to attenuate myocardial cell death due to ischemia/reperfusion injury. However, cellular mechanisms of cooling remain to be elucidated. Especially during reperfusion, mitochondrial dysfunction contributes to cell death by releasing apoptosis inductors. The aim of the present study was to investigate the effects of moderate therapeutic hypothermia (33.5°C) on mitochondrial mediated apoptosis in ischemia/reperfusion-injured cardiomyocytes...
April 7, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28392278/improvement-of-the-physicochemical-properties-of-co-amorphous-naproxen-indomethacin-by-naproxen-sodium
#19
Andreas Beyer, Holger Grohganz, Korbinian Löbmann, Thomas Rades, Claudia S Leopold
Improvement of the physicochemical properties of amorphous active pharmaceutical ingredients (APIs) applying the concept of co-amorphisation is a promising alternative to the use of polymer glass solutions. In co-amorphous systems, the physical stability and the dissolution rate of the involved components may be improved in comparison to the respective single amorphous phases. However, for the co-amorphous naproxen-indomethacin model system it has been reported that recrystallization could not be prevented for more than 112days regardless of the applied preparation method and blend ratio In the present study, it was thus tested if the physicochemical properties of co-amorphous naproxen-indomethacin could be optimized by incorporation of the naproxen sodium into the system...
April 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28386667/dynamic-modeling-of-temperature-change-in-outdoor-operated-tubular-photobioreactors
#20
Dominic Deo Androga, Basar Uyar, Harun Koku, Inci Eroglu
In this study, a one-dimensional transient model was developed to analyze the temperature variation of tubular photobioreactors operated outdoors and the validity of the model was tested by comparing the predictions of the model with the experimental data. The model included the effects of convection and radiative heat exchange on the reactor temperature throughout the day. The temperatures in the reactors increased with increasing solar radiation and air temperatures, and the predicted reactor temperatures corresponded well to the measured experimental values...
April 6, 2017: Bioprocess and Biosystems Engineering
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