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https://www.readbyqxmd.com/read/29138055/merkel-cells-sense-cooling-with-trpm8-channels
#1
Valentine Bouvier, Yann Roudaut, Nancy Osorio, Jean-Marc Aimonetti, Edith Ribot-Ciscar, Virginie Penalba, Thierry Merrot, Nicolas Lebonvallet, Christelle Le Gall-Ianotto, Laurent Misery, Patrick Delmas, Marcel Crest
In the skin, Merkel cells (MCs) connect with keratinocytes and Aβ nerve fibers to form a touch receptor which functions as a slow adapting mechanoreceptor (SA1 receptor). In human and mouse MCs, we observed an increased concentration of intracellular Ca(2+) ions in response to cold temperature and transient receptor potential melastatine 8 (TRPM8) ion channel agonists. A reduction in the response to cooling and TRPM8 agonists occurred following addition of TRPM8 antagonists, as well as in TRPM8 knockout mice...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29133253/the-oxidative-stress-and-antioxidant-responses-of-live-chinese-shrimp-fenneropenaeuschinensis-to-low-temperature-and-air-exposure
#2
Zihan Xu, Joe M Regenstein, Dandan Xie, Wenjing Lu, Xingchen Ren, Jiajia Yuan, Linchun Mao
Low temperature and air exposure were the key attributes for waterless transportation of fish and shrimp. In order to investigate the oxidative stress and antioxidant responses of the live shrimp Fenneropenaeuschinensis in the mimic waterless transportation, live Chinese shrimp were cooled at 13 °C for 3 min, stored in oxygen at 15 °C for 12 h, and then revived in water at 25 °C. The survival rate of shrimp under this waterless transportation system was over 86.67%. The ultrastructure of hepatopancreas cells were observed while activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), glutathione peroxidase (GSH-Px), antisuperoxide anion free radicals (ASAFR), total antioxidant capacity (TAOC), reactive oxygen species (ROS) production, content of malondialdehyde (MDA) and relative mRNA expressions of CAT and GSH-Px in the hemolymph and hepatopancreas were determined...
November 10, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29133175/role-of-kcnq2-channels-in-orofacial-cold-sensitivity-kcnq2-upregulation-in-trigeminal-ganglion-neurons-after-infraorbital-nerve-chronic-constrictive-injury
#3
Jennifer Ling, Ferhat Erol, Jianguo G Gu
Sensitivity to cooling temperatures often becomes heightened in orofacial regions leading to orofacial cold allodynia/hyperalgesia after chronic trigeminal nerve injury. KCNQ2 channels are involved in controlling excitability of primary afferent neurons and thereby regulate sensory functions under both physiological and pathological conditions. In the present study, we sought to determine whether KCNQ2 channels in trigeminal nerves are involved in regulating orofacial operant behavioral responses to cooling stimulation...
November 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29130534/skin-squames-contribute-to-ammonia-and-volatile-fatty-acids-production-from-bacteria-colonising-in-air-cooling-units-with-odour-complaints
#4
Tsz Wai Ng, Pui Ying Chan, Tsz Ting Chan, Haoxiang Wu, Ka Man Lai
One of the most notable indoor air quality problems is odour emission. This study investigated the potential contribution of skin squames to the production of ammonia (NH3 ) and volatile organic acids (VFAs) by seven bacteria isolated from air-cooling (AC) units with complaints of urine and body odours. Our previous study showed that keratinolytic activity is higher in AC units with odour complaints than those without. In the offices where these units are located, the most likely source of keratins is from human skin squames...
November 12, 2017: Indoor Air
https://www.readbyqxmd.com/read/29129987/increasing-the-fungicidal-action-of-amphotericin-b-by-inhibiting-the-nitric-oxide-dependent-tolerance-pathway
#5
Kim Vriens, Phalguni Tewari Kumar, Caroline Struyfs, Tanne L Cools, Pieter Spincemaille, Tadej Kokalj, Belém Sampaio-Marques, Paula Ludovico, Jeroen Lammertyn, Bruno P A Cammue, Karin Thevissen
Amphotericin B (AmB) induces oxidative and nitrosative stresses, characterized by production of reactive oxygen and nitrogen species, in fungi. Yet, how these toxic species contribute to AmB-induced fungal cell death is unclear. We investigated the role of superoxide and nitric oxide radicals in AmB's fungicidal activity in Saccharomyces cerevisiae, using a digital microfluidic platform, which enabled monitoring individual cells at a spatiotemporal resolution, and plating assays. The nitric oxide synthase inhibitor L-NAME was used to interfere with nitric oxide radical production...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29129002/histological-characterization-of-passiflora-pohlii-mast-root-tips-cryopreserved-using-the-v-cryo-plate-technique
#6
Mariela J Simão, Myriam Collin, Renata O Garcia, Elisabeth Mansur, Georgia Pacheco, Florent Engelmann
Cryopreservation stands out as the main strategy to ensure safe and cost efficient long-term conservation of plant germplasm, especially for biotechnological materials. However, the injuries associated with the procedure may result in structural damage and low recovery rates after cooling. Histological analysis provides useful information on the effects of osmotic dehydration, LN exposure, and recovery conditions on cellular integrity and tissue organization, allowing the determination of the critical steps of the cryopreservation protocol and, thus, the use of optimized treatments...
November 12, 2017: Protoplasma
https://www.readbyqxmd.com/read/29128212/liver-proteomic-analysis-of-postpartum-holstein-cows-exposed-to-heat-stress-or-cooling-conditions-during-the-dry-period
#7
Amy L Skibiel, Maya Zachut, Bruno C do Amaral, Yishai Levin, Geoffrey E Dahl
Heat stress negatively affects cow performance, compromises immune function, and increases susceptibility to metabolic disorders, particularly during the dry period and as cows transition from gestation to lactation. Metabolic adaptations of the liver are critical for successful transition, yet it is unclear how heat stress affects metabolic pathways within the liver at the proteomic level. The objective of this study was to investigate the liver proteome of postpartum cows that were cooled or heat stressed during the dry period to gain insight into how protein expression is altered by prior heat stress and may contribute to performance and disease outcomes...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29127295/clinical-potential-of-an-enzyme-based-novel-therapy-for-cocaine-overdose
#8
Ting Zhang, Xirong Zheng, Ziyuan Zhou, Xiabin Chen, Zhenyu Jin, Jing Deng, Chang-Guo Zhan, Fang Zheng
It is a grand challenge to develop a truly effective medication for treatment of cocaine overdose. The current available, practical emergence treatment for cocaine overdose includes administration of a benzodiazepine anticonvulsant agent (e.g. diazepam) and/or physical cooling with an aim to relieve the symptoms. The inherent difficulties of antagonizing physiological effects of drugs in the central nervous system have led to exploring protein-based pharmacokinetic approaches using biologics like vaccines, monoclonal antibodies, and enzymes...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122961/whole-body-heat-stress-and-exercise-stimulate-the-appearance-of-platelet-microvesicles-in-plasma-with-limited-influence-of-vascular-shear-stress
#9
Eurico N Wilhelm, José González-Alonso, Scott T Chiesa, Steven J Trangmar, Kameljit K Kalsi, Mark Rakobowchuk
Intense, large muscle mass exercise increases circulating microvesicles, but our understanding of microvesicle dynamics and mechanisms inducing their release remains limited. However, increased vascular shear stress is generally thought to be involved. Here, we manipulated exercise-independent and exercise-dependent shear stress using systemic heat stress with localized single-leg cooling (low shear) followed by single-leg knee extensor exercise with the cooled or heated leg (Study 1, n = 8) and whole-body passive heat stress followed by cycling (Study 2, n = 8)...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29116775/elucidating-the-methylammonium-ma-conformation-in-mapbbr3-perovskite-with-application-in-solar-cells
#10
Carlos A López, María Victoria Martínez-Huerta, María Consuelo Alvarez-Galván, Paula Kayser, Patricia Gant, Andres Castellanos-Gomez, María T Fernández-Díaz, Francois Fauth, José A Alonso
Hybrid organic-inorganic perovskites, MAPbX3 (X = halogen), containing methylammonium (MA: CH3-NH3(+)) in the large voids conformed by the PbX6 octahedral network, are the active absorption materials in the new generation of solar cells. CH3NH3PbBr3 is a promising member with a large band gap that gives rise to a high open circuit voltage. A deep knowledge of the crystal structure and, in particular, the MA conformation inside the perovskite cage across the phase transitions undergone below room temperature, seems essential to establish structure-property correlations that may drive to further improvements...
November 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29114087/the-cooling-compound-icilin-attenuates-autoimmune-neuroinflammation-through-modulation-of-the-t-cell-response
#11
Benjamin W Ewanchuk, Euan R O Allan, Amy L Warren, Rithwik Ramachandran, Robin M Yates
The synthetic supercooling drug, icilin, and its primary receptor target, the cation channel transient receptor potential (TRP) melastatin-8 (TRPM8), have been described as potent negative regulators of inflammation in the colon. The aim of this study was to determine whether the anti-inflammatory action of icilin could potentially be used to treat autoimmune neuroinflammatory disorders, such as multiple sclerosis (MS). During experimental autoimmune encephalomyelitis (EAE)-a CD4(+) T cell-driven murine model of MS-we found that both wild-type (WT) and TRPM8-deficient EAE mice were protected from disease progression during icilin treatment, as evidenced by delays in clinical onset and reductions in neuroinflammation...
November 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29107875/the-henry-s-constant-of-monochloramine
#12
Miguel A Garcia, Michael A Anderson
Monochloramine is a secondary disinfectant used in drinking water and is also formed in chlorinated wastewater. While known to hydrolyze over time and react with dissolved organic matter, its partitioning between the aqueous and gas phase has not been extensively studied. Preliminary experiments demonstrated that monochloramine concentrations in solutions open to the atmosphere or actively aerated decreased more rapidly than in sealed solutions, indicating significant losses to the atmosphere. For example, a monochloramine solution open to the atmosphere yielded a loss rate constant of 0...
October 30, 2017: Chemosphere
https://www.readbyqxmd.com/read/29107770/nocebo-induced-modulation-of-cerebral-itch-processing-an-fmri-study
#13
Missanga F van de Sand, Mareike M Menz, Christian Sprenger, Christian Büchel
It has been shown repeatedly that perceiving itch-related pictures or listening to a lecture on itch can enhance itch sensation and scratching behaviour (Niemeier and Gieler, 2000; Holle et al., 2012; Lloyd et al., 2013), indicating that itch is strongly influenced by expectations. Using fMRI, we investigated the neural correlates of the itch-related nocebo effect in healthy male and female human subjects. Itch sensation on the left forearm was induced by cutaneous histamine application and thermally modulated, with cooling leading to higher itch...
October 28, 2017: NeuroImage
https://www.readbyqxmd.com/read/29107631/cryopreservation-of-sperm-from-the-coral-acropora-humilis
#14
Voranop Viyakarn, Suchana Chavanich, Gabriella Chong, Sujune Tsai, Chiahsin Lin
Corals are sensitive to minute changes in their environments, and their continued existence is substantially threatened by the increasing number of destructive anthropogenic activities and unprecedented rates of climate change. Although cryopreservation has been successfully to preserve mammalian gametes for decades, coral cryopreservation was attempted for the first time less than 15 years ago, and freezing protocols exist for only a handful of coral species. The present study developed a cryopreservation protocol for the sperm of the common Indo-Pacific reef-builder Acropora humilis...
October 28, 2017: Cryobiology
https://www.readbyqxmd.com/read/29105107/sunscreen-formulations-do-not-interfere-with-sweat-cooling-during-exercise
#15
Hao Ou-Yang, Karen Meyer, Tim Houser, Gary Grove
OBJECTIVE: Sweating plays a critical role in maintaining thermal balance and keeping skin cool during exercise. People often wear sunscreens on hot summer days for sun protection. Most recreational sunscreens are designed to be water and sweat resistant, so that sweating will not remove or compromise the protection. The objective of this study was to determine whether wearing sweat-resistant sunscreen might impede natural sweating, potentially interfering with thermal regulation and resulting in the elevation of skin temperature...
November 3, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29104569/a-linear-19-mer-plant-defensin-derived-peptide-acts-synergistically-with-caspofungin-against-candida-albicans-biofilms
#16
Tanne L Cools, Caroline Struyfs, Jan W Drijfhout, Soňa Kucharíková, Celia Lobo Romero, Patrick Van Dijck, Marcelo H S Ramada, Carlos Bloch, Bruno P A Cammue, Karin Thevissen
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co-administered with caspofungin, the preferred antimycotic to treat such infections. In this study, we identified the smallest linear HsAFP1-derived peptide that acts synergistically with caspofungin or anidulafungin against C. albicans as HsLin06_18, a 19-mer peptide derived from the C-terminal part of HsAFP1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29104366/characterizing-dynamic-sensory-properties-of-nutritive-and-nonnutritive-sweeteners-with-temporal-check-all-that-apply
#17
M Michelle Reyes, John C Castura, John E Hayes
Temporal Check-All-That-Apply (TCATA) is a rapid method where attributes are actively checked and unchecked to track sensations over time, so that the checked words fully describe the sample in any given moment. Here, we characterize the temporal profiles of sweeteners using TCATA. In two experiments, sweeteners were tested in water at concentrations known to elicit weak to moderate sweetness. Before evaluating the sweeteners, participants (n= ~125 per experiment) were familiarized with the TCATA method with a guided example using imaginary samples of Kool-Aid...
June 2017: Journal of Sensory Studies
https://www.readbyqxmd.com/read/29102843/concentrating-solar-power-plants-versus-groundwater-resources-in-mediterranean-areas-of-spain-the-environmental-dilemma
#18
Luis Moreno Merino, Núria Imbern Fernández, Juan José Durán Valsero, Héctor Aguilera
Concentrating solar power plants (CSPPs) are considered to be particularly respectful of the environment but under Mediterranean climate where surface water scarcity is a key issue, these types of electrical plants usually require groundwater for their cooling towers and use the same aquifers to discharge their salinized effluents. This study analyses de Spanish case, where fifteen out of the fifty active CSPPs use groundwater directly, four discharge their effluents to infiltration ponds and forty-three to surface watercourses most of which recharge underlying aquifers...
November 2, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29100864/sustained-simultaneous-delivery-of-metronidazole-and-doxycycline-from-polycaprolactone-matrices-designed-for-intravaginal-treatment-of-pelvic-inflammatory-disease
#19
Meenakshi Pathak, Allan G A Coombes, BoMi Ryu, Peter J Cabot, Mark S Turner, Cheryn Palmer, Dongjie Wang, Kathryn J Steadman
Poly(ɛ-caprolactone) (PCL) intra-vaginal matrices were produced for local delivery of a combination of antibacterials, by rapidly cooling a mixture of drug powders dispersed in PCL solution. Matrices loaded with different combinations of metronidazole (10, 15 and 20% w/w) and doxycycline (10% w/w), were evaluated in vitro for release behavior and antibacterial activity. Rapid 'burst release' of 8-15% of the doxycycline content and 31-37% of the metronidazole content occurred within 24 h when matrices were immersed in simulated vaginal fluid (SVF) at 37°C...
October 31, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29095727/anaesthesiology-research-in-the-european-union-and-the-european-free-trade-association-an-overview-from-2001-to-2015
#20
Evelien Cools, Julia Ausserer, Marc Van de Velde, Peter Hamm, Sabrina Neururer, Peter Paal
BACKGROUND: Publication performance in anaesthesiology hints at research activity and attractiveness for a particular centre or country for anaesthetists. OBJECTIVE: The aim of this retrospective bibliographic study is to compare the publication performance of anaesthesiology departments within the countries of the European Union (EU) and European Free Trade Association (EFTA) combined. Outcome measures were the number of publications, the number of original articles, the average impact factor and the number of publications and average impact factor per million inhabitants...
December 2017: European Journal of Anaesthesiology
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