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https://www.readbyqxmd.com/read/28649144/motivational-interviewing-or-counseling-medical-therapies-or-no-intervention-to-improve-tobacco-cessation-in-adults-and-adolescents
#1
Abigail R Norris, Jan E Miller
CLINICAL QUESTION: In adults and adolescents using cigarettes and/or smokeless tobacco, is motivational interviewing (MI) more effective compared to counseling, medical therapies or no intervention for improving tobacco cessation? ANSWER: Yes. Evidence is modest but conclusive that using MI alone or in conjunction with other therapies results in greater rates of tobacco cessation compared to interventions that did not include MI. LEVEL OF EVIDENCE OF THE ANSWER: A...
March 2017: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/28645861/protective-effect-of-lycium-barbarum-polysaccharides-on-dextromethorphan-induced-mood-impairment-and-neurogenesis-suppression
#2
Kevin Kai-Ting Po, Joseph Wai-Hin Leung, Jackie Ngai-Man Chan, Timothy Kai-Hang Fung, Dalinda Isabel Sánchez-Vidaña, Emily Lok-Lam Sin, Kwok-Fai So, Benson Wui-Man Lau, Andrew Man-Hong Siu
Dextromethorphan (DXM) is one of the common drugs abused by adolescents. It is the active ingredient found in cough medicine which is used for suppressing cough. High dosage of DXM can induce euphoria, dissociative effects and even hallucinations. Chronic use of DXM may also lead to depressive-related symptoms. Lycium barbarum, commonly known as wolfberry, has been used as a traditional Chinese medicine for the treatment of ageing-related neurodegenerative diseases. A recent study has shown the potential beneficial effect of Lycium barbarum to reduce depression-like behavior...
June 20, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28645136/childhood-traumatic-experiences-and-the-association-with-marijuana-and-cocaine-use-in-adolescence-through-adulthood
#3
Joy D Scheidell, Kelly Quinn, Susan P McGorray, B Christopher Frueh, Nisha N Beharie, Linda B Cottler, Maria R Khan
BACKGROUND AND AIMS: Examination of longitudinal relationships between childhood traumatic experiences and drug use across the life-course at the national level, with control of confounding by other forms of trauma, is needed. We aimed to estimate the prevalence of nine typologies of childhood traumas and the cumulative number experienced, correlation between traumas, and associations between individual and cumulative number of traumas with drug use during adolescence, emerging adulthood, and adulthood...
June 23, 2017: Addiction
https://www.readbyqxmd.com/read/28642080/impact-of-juvenile-chronic-stress-on-adult-cortico-accumbal-function-implications-for-cognition-and-addiction
#4
REVIEW
Michael J Watt, Matthew A Weber, Shaydel R Davies, Gina L Forster
Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One possible explanation lies in stress-induced disruption to the development of specific brain regions associated with executive function and reward processing, deficits in which are common to the disorders promoted by childhood stress...
June 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28639495/substance-use-in-adolescents-with-mental-illness-in-durban-south-africa
#5
Bhoodeo Taukoor, Saeeda Paruk, Enver Karim, Jonathan K Burns
Comorbid substance use in adolescents with mental illness is often an indicator of poor treatment outcome. This study aims to determine the prevalence of, and associated risk factors for, substance use in adolescents with mental illness attending a mental health service. Data was collected from hospital records of 162 adolescents, using a structured data sheet, over a two-year period. Substance use was more significant in older adolescents and those with severe mental illness. Sixty-two (38.3%) adolescents used substances...
May 2017: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/28635664/adolescent-exposure-to-the-synthetic-cannabinoid-win-55212-2-modifies-cocaine-withdrawal-symptoms-in-adult-mice
#6
María A Aguilar, Juan Carlos Ledesma, Marta Rodríguez-Arias, Carles Penalva, Carmen Manzanedo, José Miñarro, M Carmen Arenas
Chronic cannabinoid consumption is an increasingly common behavior among teenagers and has been shown to cause long-lasting neurobehavioral alterations. Besides, it has been demonstrated that cocaine addiction in adulthood is highly correlated with cannabis abuse during adolescence. Cocaine consumption and subsequent abstinence from it can cause psychiatric symptoms, such as psychosis, cognitive impairment, anxiety, and depression. The aim of the present research was to study the consequences of adolescent exposure to cannabis on the psychiatric-like effects promoted by cocaine withdrawal in adult mice...
June 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28623823/a-randomized-placebo-controlled-trial-of-n-acetylcysteine-for-cannabis-use-disorder-in-adults
#7
Kevin M Gray, Susan C Sonne, Erin A McClure, Udi E Ghitza, Abigail G Matthews, Aimee L McRae-Clark, Kathleen M Carroll, Jennifer S Potter, Katharina Wiest, Larissa J Mooney, Albert Hasson, Sharon L Walsh, Michelle R Lofwall, Shanna Babalonis, Robert W Lindblad, Steven Sparenborg, Aimee Wahle, Jacqueline S King, Nathaniel L Baker, Rachel L Tomko, Louise F Haynes, Ryan G Vandrey, Frances R Levin
BACKGROUND: Cannabis use disorder (CUD) is a prevalent and impairing condition, and established psychosocial treatments convey limited efficacy. In light of recent findings supporting the efficacy of N-acetylcysteine (NAC) for CUD in adolescents, the objective of this trial was to evaluate its efficacy in adults. METHODS: In a 12-week double-blind randomized placebo-controlled trial, treatment-seeking adults ages 18-50 with CUD (N=302), enrolled across six National Drug Abuse Treatment Clinical Trials Network-affiliated clinical sites, were randomized in a 1:1 ratio to a 12-week course of NAC 1200mg (n=153) or placebo (n=149) twice daily...
June 10, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28622813/evaluation-of-drug-use-and-medication-compliance-in-adolescents-admitted-to-a-psychiatric-facility-from-the-pediatric-emergency-department
#8
George Sam Wang, Genie Roosevelt, Amy Becker, Lina Brou, Jeffrey L Galinkin
OBJECTIVES: Knowledge of drug use and medication compliance during mental health evaluation can help guide evaluation and treatment. The objective was to evaluate drug use and medication compliance in a pediatric emergency department (PED) psychiatric population by comparing medical history, standard urine drug screen (EIA), and expanded urine drug screen (HPLC-MS/MS). METHODS: A prospective cohort study of admitted psychiatric patients ≥13years and ≤18years in a tertiary-care children's hospital psychiatric ED from January 31, 2013 through April 16, 2014...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28622627/changes-in-nonhuman-primate-brain-function-following-chronic-alcohol-consumption-in-previously-na%C3%A3-ve-animals
#9
Jared A Rowland, Jennifer R Stapleton-Kotloski, Greg E Alberto, April T Davenport, Robert J Kotloski, David P Friedman, Dwayne W Godwin, James B Daunais
INTRODUCTION: Chronic alcohol abuse is associated with neurophysiological changes in brain activity; however, these changes are not well localized in humans. Non-human primate models of alcohol abuse enable control over many potential confounding variables associated with human studies. The present study utilized high-resolution magnetoencephalography (MEG) to quantify the effects of chronic EtOH self-administration on resting state (RS) brain function in vervet monkeys. METHODS: Adolescent male vervet monkeys were trained to self-administer ethanol (n=7) or an isocaloric malto-dextrin solution (n=3)...
May 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28621645/patterns-and-factors-of-problematic-marijuana-use-in-the-canadian-population-evidence-from-three-cross-sectional-surveys
#10
W I Andrew Bonner, Mustafa Andkhoie, Charlene Thompson, Marwa Farag, Michael Szafron
OBJECTIVES: The objectives of this study are to describe marijuana use in Canada and explore factors associated with problematic use. METHODS: Data from the 2010-2012 circulations of the Canadian Alcohol and Drug Use Monitoring Survey were used to create three logistic regression models for the purposes of identifying and comparing factors associated with the degree of marijuana use, as determined via the WHO Alcohol, Smoking and Substance Abuse Involvement Screening Test (non-problematic, problematic) and European Monitoring Centre for Drugs and Drug Addiction (experiential, recent, current) methods...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28620875/predictors-of-health-related-quality-of-life-in-maltreated-children-and-adolescents
#11
Sabine Weber, Andreas Jud, Markus A Landolt, Lutz Goldbeck
PURPOSE: Research on the consequences of child maltreatment has primarily focused on behavior and mental health; the children's overall well-being has not received the same attention. A number of studies have investigated health-related quality of life (HRQoL) among victims of child maltreatment, but there is still a lack of knowledge about predictors of HRQoL in maltreated children and adolescents. This study seeks to bridge the gap by drawing data from the German multi-site study Child Abuse and Neglect Case-Management (CANMANAGE)...
June 15, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28620555/a-discussion-of-high-risk-hpv-in-a-6-year-old-female-survivor-of-child-sexual-abuse
#12
Connie D Cao, Lena Merjanian, Joelle Pierre, Adrian Balica
BACKGROUND: Human papilloma viruses (HPVs) cause a variety of clinical manifestations in children including skin warts, laryngeal papillomas, and condyloma acuminatum. Whereas the mode of transmission is well understood and management of HPV infection is clearly defined by guidelines in adults, less is known about the mode of transmission, natural history of disease, and appropriate management of high-risk anogenital HPV infections in children. CASE: The patient is a previously healthy 6-year-old female who presented with multiple vaginal lesions causing pain and discomfort and was diagnosed with HPV 18 positive CIN I...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28615948/marijuana-use-recent-marijuana-initiation-and-progression-to-marijuana-use-disorder-among-young-male-and-female-adolescents-aged-12-14-living-in-us-households
#13
Valerie L Forman-Hoffman, Cristie Glasheen, Kathryn R Batts
Marijuana initiation during adolescence, and early adolescence in particular, is associated with adverse health consequences. Our study used 2005-2014 data from the annual, cross-sectional National Survey on Drug Use and Health to study the prevalence and correlates of marijuana initiation, use, and marijuana use disorder (MUD; abuse or dependence) among 12- to 14-year olds living in civilian US households (n = 84 954). Examined correlates included age, sex, race/ethnicity, poverty status, metropolitan status, year of survey, depression, tobacco use, alcohol use, and fighting at school...
2017: Substance Abuse: Research and Treatment
https://www.readbyqxmd.com/read/28612521/could-modafinil-prevent-psychostimulant-addiction-an-experimental-study-in-rats
#14
Verônica Tironi Dias, Luciana Taschetto Vey, Higor Zuquetto Rosa, Lívia Ferraz D'avila, Raquel Cristine Silva Barcelos, Marilise Escobar Burger
Addiction is a serious health problem which leads to general social impairment. The period of adolescence plays a significant role in drug abuse liability. Psychostimulants, such as modafinil (MOD), are majorly used by teenagers seeking improvements in cognition, which contributes to its indiscriminate use. The present study aimed to investigate the influence of MOD (64 mg/kg by gavage, once a day) treatment during adolescence (PND 28-42) on amphetamine (AMPH, 4 mg/kg i.p.) conditioned place preference (CPP) in early adulthood (PND 60)...
June 14, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28610574/predicting-evidence-based-treatment-sustainment-results-from-a-longitudinal-study-of-the-adolescent-community-reinforcement-approach
#15
Sarah B Hunter, Bing Han, Mary E Slaughter, Susan H Godley, Bryan R Garner
BACKGROUND: Implementation support models are increasingly being used to enhance the delivery of evidence-based treatments (EBTs) in routine care settings. Little is known about the extent to which these models lead to continued EBT use after implementation support ends. Moreover, few empirical studies longitudinally examine the hypothesized factors associated with long-term psychosocial EBT use (i.e., sustainment). In an effort to address this gap, the current study examined sustainment of an EBT called the Adolescent-Community Reinforcement Approach (A-CRA) following the end of implementation support...
June 13, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28609748/neighborhood-characteristics-and-prescription-drug-misuse-among-adolescents-the-importance-of-social-disorganization-and-social-capital
#16
Jason A Ford, Sarah Ann Sacra, Alexis Yohros
BACKGROUND: Prior research on prescription drug misuse has focused on identifying individual risk factors. While a few studies examine differences in misuse based on geographic residence, there is a lack of research that examines the relevance of neighbourhood characteristics. METHODS: The current research used data from the 2000 National Household Survey on Drug Abuse, a sample of respondents that was generalizable to the non-institutionalised population of the United States...
June 10, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28606631/restraint-stress-enhances-alcohol-intake-in-adolescent-female-rats-but-reduces-alcohol-intake-in-adolescent-male-and-adult-female-rats
#17
Aranza Wille-Bille, Ana Ferreyra, Martina Sciangula, Florencia Chiner, Michael E Nizhnikov, Ricardo Marcos Pautassi
Adolescents may be more sensitive to stress-induced alcohol drinking than adults, which would explain the higher prevalence of alcohol abuse and dependence in late adolescence than in adulthood. The present study analyzed the impact of restraint stress on the initiation of alcohol intake across 2 weeks of intermittent, two-bottle choice intake in male and female adolescent rats and adult female rats. Restraint stress significantly increased alcohol intake and preference in female adolescent rats but decreased alcohol intake and preference in male adolescent and female adult rats...
June 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28606210/impulsivity-as-a-mechanism-linking-child-abuse-and-neglect-with-substance-use-in-adolescence-and-adulthood
#18
Assaf Oshri, Steve M Kogan, Josephine A Kwon, K A S Wickrama, Lauren Vanderbroek, Abraham A Palmer, James MacKillop
Emerging developmental perspectives suggest that adverse rearing environments promote neurocognitive adaptations that heighten impulsivity and increase vulnerability to risky behavior. Although studies document links between harsh rearing environments and impulsive behavior on substance use, the developmental hypothesis that impulsivity acts as mechanism linking adverse rearing environments to downstream substance use remains to be investigated. The present study investigated the role of impulsivity in linking child abuse and neglect with adult substance use using data from (a) a longitudinal sample of youth (Study 1, N = 9,421) and (b) a cross-sectional sample of adults (Study 2, N = 1,011)...
June 13, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28605163/associations-of-bullying-and-cyberbullying-with-substance-use-and-sexual-risk-taking-in-young-adults
#19
George Kritsotakis, Maria Papanikolaou, Emmanouil Androulakis, Anastas E Philalithis
PURPOSE: This study aims at identifying the sex-stratified associations of involvement in traditional bullying during middle and high school years and in cyberbullying during college years with multiple health risk behaviors in undergraduate students. DESIGN: This cross-sectional analysis draws on the data of the second wave of the LATO study (Lifestyle & Attitudes in a Student Population) in Greece. METHODS: During November and December 2013, 812 second-year undergraduate students (mean age = 19...
June 12, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28600961/uplc-ms-ms-assay-for-identification-and-quantification-of-brivaracetam-in-plasma-sample-application-to-pharmacokinetic-study-in-rats
#20
Muzaffar Iqbal, Essam Ezzeldin, Khalid A Al-Rashood
Brivaracetam (BVR) is a novel antiepileptic drug (AED), approved clinically for the treatment of partial onset seizures in adults and adolescents. It has some abuse potential and assigned to Schedule V category under the Controlled Substance Act by the Drug Enforcement Administration. Being an AED and drug of abuse, a sensitive and robust assay is necessary for determination of BVR in biological fluids. Herein, we report a sensitive and validated UPLC-MS/MS assay for identification and quantification of BVR in plasma samples...
June 4, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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