keyword
MENU ▼
Read by QxMD icon Read
search

Iacuc

keyword
https://www.readbyqxmd.com/read/28211866/response-to-protocol-review-scenario-new-procedure-requires-iacuc-review
#1
Deyanira Santiago, Ann Marie Dinkel
No abstract text is available yet for this article.
February 17, 2017: Lab Animal
https://www.readbyqxmd.com/read/28185611/retrospective-analysis-of-reproductive-performance-of-pair-bred-compared-with-trio-bred-mice
#2
Katherine Wasson
Federal guidelines provide recommendations regarding the minimum of floor space that should be allotted for breedinglaboratory rodents. Mouse mating systems used by a variety of institutions frequently deviate from these recommendations.Regulatory agencies suggest that deviations from established guidelines should be assessed on an institutional basis andrecommend periodic review by the local IACUC. Mouse breeding data, collected in a laboratory animal management softwareprogram at a single institution, were retrospectively analyzed to determine the effects of 2 breeding schemes on reproductiveperformance...
February 9, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28165833/diclofenac-sodium-ion-exchange-resin-complex-loaded-melt-cast-films-for-sustained-release-ocular-delivery
#3
Goutham R Adelli, Sai Prachetan Balguri, Prakash Bhagav, Vijayasankar Raman, Soumyajit Majumdar
PURPOSE: The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFSfree) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles, respectively. METHODS: Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFSfree, or a combination of DFSfree + DFS:IR loaded matrix films were prepared by melt-cast technology...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28047827/su-c-204-01-a-dosimetric-investigation-into-the-effects-of-yttrium-90-radioembolization-on-the-gi-tract-in-vivo-and-histological-analysis-in-an-animal-model
#4
A Pasciak, L Nodit, A Bourgeois, B Paxton, A Arepally, Y Bradley
PURPOSE: In Yttrium-90 (90Y) radioembolization, non-target embolization (NTE) to the stomach or small bowel can result in ulceration, a rare but difficult to manage clinical complication. However, dosimetric thresholds for toxicity to these tissues from radioembolization have never been evaluated in a controlled setting. We performed an analysis of the effect of 90Y radioembolization in a porcine model at different absorbed-dose endpoints. METHODS: Under approval of the University of Tennessee IACUC, 6 female pigs were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047017/su-c-204-07-radiation-therapy-as-a-potential-treatment-for-obesity-initial-data-from-a-preclinical-investigation
#5
A Pasciak, Y Bradley, L Nodit, A Bourgeois, B Paxton, A Arepally
PURPOSE: To evaluate the feasibility of Yttrium-90 (90Y) radionuclide therapy as a potential treatment for obesity in a porcine model. As the only appetite-stimulating hormone, localized targeting of ghrelin-producing X/A cells in the fundus of the stomach using 90Y may reduce serum ghrelin levels and decrease hunger. METHODS: Under approval of the University of Tennessee IACUC, 8 young female pigs aged 12-13 weeks and weighing 21.8-28.1 Kg were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046891/we-fg-206-12-enhanced-laws-textures-a-potential-mri-surrogate-marker-of-hepatic-fibrosis-in-a-murine-model
#6
B Li, H Yu, H Jara, J Soto, S Anderson
PURPOSE: To compare enhanced Laws texture derived from parametric proton density (PD) maps to other MRI-based surrogate markers (T2, PD, ADC) in assessing degrees of liver fibrosis in a murine model of hepatic fibrosis using 11.7T scanner. METHODS: This animal study was IACUC approved. Fourteen mice were divided into control (n=1) and experimental (n=13). The latter were fed a DDC-supplemented diet to induce hepatic fibrosis. Liver specimens were imaged using an 11...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27991869/terminal-procedures-should-an-iacuc-require-a-literature-review-for-less-painful-alternatives
#7
Jerald Silverman
No abstract text is available yet for this article.
December 19, 2016: Lab Animal
https://www.readbyqxmd.com/read/27856399/enhanced-laws-textures-a-potential-mri-surrogate-marker-of-hepatic-fibrosis-in-a-murine-model
#8
Baojun Li, Hernan Jara, Heishun Yu, Michael O'Brien, Jorge Soto, Stephan W Anderson
PURPOSE: To compare enhanced Laws textures derived from parametric proton density (PD) maps to other MRI surrogate markers (T2, PD, apparent diffusion coefficient (ADC)) in assessing degrees of liver fibrosis in an ex vivo murine model of hepatic fibrosis imaged using 11.7T MRI. METHODS: This animal study was IACUC approved. Fourteen male, C57BL/6 mice were divided into control and experimental groups. The latter were fed a 3,5-dicarbethoxy-1,4-dihydrocollidine (DDC) supplemented diet to induce hepatic fibrosis...
November 14, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27716434/oestrogen-induced-angiogenesis-and-implantation-contribute-to-the-development-of-parasitic-myomas-after-laparoscopic-morcellation
#9
Ben-Shian Huang, Muh-Hwa Yang, Peng-Hui Wang, Hsin-Yang Li, Teh-Ying Chou, Yi-Jen Chen
BACKGROUND: Iatrogenic parasitic myomas (PMs), caused by intra-corporeal power morcellation during laparoscopy is gradually increasing. However, the pathogenesis and medical treatment of PMs remain largely unelucidated. METHODS: Laparoscopically-induced PM xenografted mouse model was conducted by xenografting human uterine myoma fragments into the abdominal cavity of SCID mice and hormonal manipulation was performed using this mouse model to demonstrate the role of oestrogen in the development of implanted PMs...
October 6, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27664339/quiescent-pluripotent-stem-cells-reside-within-murine-peripheral-nerves-that-can-be-stimulated-to-proliferate-by-recombinant-human-bone-morphogenic-protein-2-or-by-nerve-trauma
#10
Michael H Heggeness, Nora Strong, Paul H Wooley, Shang-You Yang
BACKGROUND: The clinical use of recombinant human bone morphogenic protein 2 (rhBMP-2, Infuse) has been associated with nerve-related complications including new-onset sciatica, and retrograde ejaculation. PURPOSE: To better understand the interaction of rhBMP-2 and peripheral nerves with the intent of making procedures safer. STUDY DESIGN/SETTING: Using a mouse model to examine the direct effect of diluted rhBMP-2 (Infuse) on murine sciatic nerves...
September 21, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27606820/lapse-in-institutional-animal-care-and-use-committee-continuing-reviews
#11
Min-Fu Tsan, Michael Grabenbauer, Yen Nguyen
The United States federal animal welfare regulations and the Public Health Service Policy on Humane Care and Use of Laboratory Animals require that institutional animal care and use committees (IACUCs) conduct continuing reviews of all animal research activities. However, little is known about the lapse rate of IACUC continuing reviews, and how frequently investigators continue research activities during the lapse. It is also not clear what factors may contribute to an institution's lapse in IACUC continuing reviews...
2016: PloS One
https://www.readbyqxmd.com/read/27584043/an-orthotopic-mouse-model-of-spontaneous-breast-cancer-metastasis
#12
Amy V Paschall, Kebin Liu
Metastasis is the primary cause of mortality of breast cancer patients. The mechanism underlying cancer cell metastasis, including breast cancer metastasis, is largely unknown and is a focus in cancer research. Various breast cancer spontaneous metastasis mouse models have been established. Here, we report a simplified procedure to establish orthotopic transplanted breast cancer primary tumor and resultant spontaneous metastasis that mimic human breast cancer metastasis. Combined with the bioluminescence live tumor imaging, this mouse model allows tumor growth and progression kinetics to be monitored and quantified...
August 14, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27551798/what-are-the-limits-of-confidentiality-for-iacuc-members
#13
Jerald Silverman
No abstract text is available yet for this article.
August 23, 2016: Lab Animal
https://www.readbyqxmd.com/read/27501853/pilot-trial-of-intravenous-lipid-emulsion-treatment-for-severe-nifedipine-induced-shock
#14
Christine M Murphy, Cliff Williams, Michael E Quinn, Brian Nicholson, Thomas Shoe, Michael C Beuhler, William P Kerns
Animal studies and human case reports show promise in using lipid rescue to treat refractory calcium channel antagonist toxicity. However, the majority of research and clinical experience has focused on non-dihydropyridine agents. Thus, we sought to investigate the value of lipid emulsion (ILE) therapy for dihydropyridine-induced shock. This IACUC-approved study utilized seven swine that were sedated with alpha-chloralose, mechanically ventilated, and instrumented for drug delivery and hemodynamic measures...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27500410/real-time-x-ray-imaging-of-lung-fluid-volumes-in-neonatal-mouse-lung
#15
Ashley E Van Avermaete, Phi T Trac, Theresa W Gauthier, My N Helms
At birth, the lung undergoes a profound phenotypic switch from secretion to absorption, which allows for adaptation to breathing independently. Promoting and sustaining this phenotype is critically important in normal alveolar growth and gas exchange throughout life. Several in vitro studies have characterized the role of key regulatory proteins, signaling molecules, and steroid hormones that can influence the rate of lung fluid clearance. However, in vivo examinations must be performed to evaluate whether these regulatory factors play important physiological roles in regulating perinatal lung liquid absorption...
2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27376143/a-nonselective-cyclooxygenase-inhibitor-enhances-the-activity-of-vinblastine-in-a-naturally-occurring-canine-model-of-invasive-urothelial-carcinoma
#16
Deborah W Knapp, Audrey Ruple-Czerniak, José A Ramos-Vara, James F Naughton, Christopher M Fulkerson, Sonia I Honkisz
Background: Chemotherapy is expected to remain an important part of invasive urothelial carcinoma (UC) treatment. Strategies to enhance chemotherapy efficacy are needed. Objective: To determine the chemotherapy-enhancing effects of a nonselective cyclooxygenase (COX) inhibitor on vinblastine in a naturally-occurring canine model of invasive UC. Methods: With IACUC approval, privately-owned dogs with naturally-occurring histologically-diagnosed invasive UC, expected survival ≥6 weeks, and informed owner consent were randomly allocated to receive vinblastine (2...
2016: Bladder Cancer
https://www.readbyqxmd.com/read/27327008/response-to-protocol-review-scenario-the-iacuc-should-not-be-involved
#17
COMMENT
Sara Tobias Savage
No abstract text is available yet for this article.
21, 2016: Lab Animal
https://www.readbyqxmd.com/read/27279698/epicatechin-plus-treadmill-exercise-are-neuroprotective-against-moderate-stage-amyloid-precursor-protein-presenilin-1-mice
#18
Zhiyuan Zhang, Hao Wu, Houcai Huang
BACKGROUND: Epidemiological evidence suggests that exercise and dietary polyphenols are beneficial in reducing Alzheimer's disease (AD) risk. MATERIALS AND METHODS: In the present study, 8 months old amyloid precursor protein/presenilin 1 (APP/PS1) mice (a moderate pathology phase) were given the green tea catechin (-)-epicatechin delivered orally in the drinking water (50 mg/kg daily), along with treadmill exercise for 4 months, in order to investigate whether the combination can ameliorate the cognitive loss and delay the progression of AD in APP/PS1 transgenic (Tg) mice...
May 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27203823/proximal-femoral-growth-modification-effect-of-screw-plate-and-drill-on-asymmetric-growth-of-the-hip
#19
Albert d'Heurle, James McCarthy, David Klimaski, Keith Stringer
BACKGROUND: Guided growth has long been used in the lower extremities but has not been applied to varus or valgus deformity in the hip, as may occur in children with cerebral palsy or developmental dysplasia of the hip. The purpose of this study was to determine if screw, plate, or drilling techniques decreased the femoral neck-shaft angle (NSA) and articular trochanteric disease (ATD), as well as describe growth plate structural changes with each method. METHODS: Twelve 8-week-old lambs underwent proximal femoral hemiepiphysiodesis (IACUC approved) using either a screw (n=4), plate (n=4), or drilling procedure (n=4)...
May 19, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27203262/iacuc-from-a-to-z
#20
Deborah Frolicher
No abstract text is available yet for this article.
May 20, 2016: Lab Animal
keyword
keyword
49833
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"