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https://www.readbyqxmd.com/read/28660807/factors-influencing-iacuc-decision-making-who-leads-the-discussions
#1
Jerald Silverman, Charles W Lidz, Jonathan Clayfield, Alexandra Murray, Lorna J Simon, Louise Maranda
Decisions about the appropriate use of animals in research are largely made by Institutional Animal Care and Use Committees (IACUCs). Several commentators claim that scientists exert excessive influence on IACUC decisions. We studied 87 protocol reviews from 10 IACUCs to assess whether any group of participants appeared to dominate the protocol discussions. Audio recordings of the meetings were coded to capture the topics of the discussions. We found that animal research scientists made the largest total number of topic mentions while community members made the fewest...
June 1, 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28644459/what-does-reporting-to-the-iacuc-mean-for-pam
#2
Jerald Silverman
No abstract text is available yet for this article.
June 23, 2017: Lab Animal
https://www.readbyqxmd.com/read/28617531/controlled-release-mitomycin-c-polylactic-acid-film-prevents-epidural-scar-hyperplasia-after-laminectomy-by-inducing-fibroblast-autophagy-and-regulating-the-expression-of-mirnas
#3
B-B Wang, H Xie, T Wu, N Xie, J Wu, Y Gu, F Tang, J Liu
OBJECTIVE: To design a new controlled-release MMC-PLA film and explore whether and how this film could prevent epidural scar hyperplasia and adhesion in a post-laminectomy rat model. MATERIALS AND METHODS: All procedures were performed under the approval and supervision of the Institutional Animal Care and Use Committee (IACUC) of Nanjing Medical University. A total of 120 Sprague-Dawley (SD) rats were randomly placed into four groups after laminectomy (each group=30 rats)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28530695/response-to-protocol-review-scenario-iacuc-approval-for-the-sake-of-prudence-not-welfare
#4
Kelly Jensen
No abstract text is available yet for this article.
May 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28530685/combining-biomedical-and-agricultural-research-is-an-iacuc-necessary-for-pilot-data-collection
#5
Jerald Silverman
No abstract text is available yet for this article.
May 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28530681/response-to-protocol-review-scenario-no-iacuc-approval-necessary-but-inspect-potential-risks
#6
Lori R Hill
No abstract text is available yet for this article.
May 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28515151/assessing-the-satisfaction-and-burden-within-an-academic-animal-care-and-use-program
#7
John N Norton, Randall P Reynolds, Cliburn Chan, Raphael H Valdivia, Herman F Staats
Although animal research requires adherence to various regulations and standards, the manner in which compliance is maintained and the degree of additional constraints varies between institutions. Regulatory burden, particularly if institutionally imposed, has become a concern for institutions as increased regulatory expectations result in decreased resources available for research efforts. Faculty, research staff, and support staff engaged in animal research were surveyed to determine what Institutional Animal Care and Use Committee (IACUC) processes were considered burdensome, the perceived value of some suggested modifications, and satisfaction with the IACUC Administrative Office and the animal resource unit...
May 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28480394/establishment-and-evaluation-of-orthotopic-hepatocellular-carcinoma-and-drug-induced-hepatocellular-carcinoma-in-mice-with-spleen-deficiency-syndrome-in-traditional-chinese-medicine
#8
Haoxuan Luo, Yan Chen, Baoguo Sun, Ting Xiang, Shijun Zhang
BACKGROUND: Spleen-deficiency syndrome (SDS) in Traditional Chinese Medicine (TCM) played pivotal roles on the development of hepatocellular carcinoma (HCC). This study was performed to establish and evaluate HCC model in mice with SDS in TCM. MATERIAL AND METHODS: A total of 90 C57BL/6 mice were randomized in six groups (n=15 for each group): A, Control group; B, SDS group; C, orthotopic HCC (OHCC) group; D, OHCC based on SDS (SDS-OHCC) group; E, Drug-induced HCC (DHCC) group; F, DHCC based on SDS (SDS-DHCC) group...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28474113/creation-of-an-extraluminal-arterial-bypass-graft-using-a-commercially-available-self-expanding-stent-graft-feasibility-study-in-a-porcine-model
#9
Jessica K Stewart, Scott S Perkins, Charles Y Kim
PURPOSE: The purpose of this study was to assess the technical feasibility of ultrasound-guided endovascular creation of a percutaneous extraluminal arterial bypass graft without a surgically created arterial anastomosis. MATERIALS AND METHODS: Nine swine were utilized for this IACUC-approved study using a carotid bypass model in swine. Using sonographic guidance, percutaneous access was obtained to the proximal and distal common carotid artery. A self-expanding stent graft was advanced through the proximal carotid access site, tunneled subcutaneously, then advanced through the distal carotid access site, and deployed...
May 4, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28452873/platelet-and-coagulation-function-before-and-after-burn-and-smoke-inhalation-injury-in-sheep
#10
Nicolas J Prat, Maryanne C Herzig, Stefan Kreyer, Robbie K Montgomery, Bijaya K Parida, Katharina Linden, Vittorio Scaravilli, Slava M Belenkiy, Leopoldo C Cancio, Andriy I Batchinsky, Andrew P Cap
BACKGROUND: Smoke inhalation and burn injury remain a major source of morbidity and mortality. There is known dysregulation of hemostasis in burn patients, but either hypercoagulation or hypocoagulation states are reported. Sheep are an established animal model for studying burn pathology and provide robust data on hemostatic function at baseline and after injury. METHODS: After an IACUC-approved protocol, 15 sheep were anesthetized and subjected to a 40% full thickness burn with smoke inhalation...
July 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28422105/what-role-should-an-iacuc-play-when-a-pi-s-manuscript-is-on-the-line
#11
Jerald Silverman
No abstract text is available yet for this article.
April 19, 2017: Lab Animal
https://www.readbyqxmd.com/read/28382685/dimethyl-fumarate-ameliorates-myoclonus-stemming-from-protein-misfolding-in-oligodendrocytes
#12
Cherie M Southwood, Danielle M Garshott, Chelsea R Richardson, Navid Seraji-Bozorgzad, Andrew M Fribley, Alexander Gow
Multiple sclerosis (MS) is considered a primary autoimmune disease; however, this view is increasingly being challenged in basic and clinical science arenas because of the growing body of clinical trials' data showing that exclusion of immune cells from the CNS only modestly slows disease progression to disability. Accordingly, there is significant need for expanding the scope of potential disease mechanisms to understand the etiology of MS. Concomitantly, the use of a broader range of pre-clinical animal models for characterizing existing efficacious clinical treatments may elucidate additional or unexpected mechanisms of action for these drugs that augment insight into MS etiology...
July 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28381309/the-interplay-of-ethics-animal-welfare-and-iacuc-oversight-on-the-reproducibility-of-animal-studies
#13
Stacy L Pritt, Robert E Hammer
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experiments within the same or among different laboratories. Over the past few years, much has been written and said about the lack of reproducibility of animal studies. Reasons that are commonly cited for this lack of reproducibility include inappropriate study design, errors in conducting the research, and potential fraud. In the quest to understand the basis for this lack of reproducibility, scientists have not fully considered the potential ramifications on ethical constructs for animal research, animal welfare considerations in animal research programs, the regulatory environment, and oversight by IACUCs...
March 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28328872/the-role-of-the-iacuc-in-ensuring-research-reproducibility
#14
REVIEW
Jerald Silverman, James Macy, Patricia A Preisig
There is a "village" of people impacting research reproducibility, such as funding panels, the IACUC and its support staff, institutional leaders, investigators, veterinarians, animal facilities, and professional journals. IACUCs can contribute to research reproducibility by ensuring that reviews of animal use requests, program self-assessments and post-approval monitoring programs are sufficiently thorough, the animal model is appropriate for testing the hypothesis, animal care and use is conducted in a manner that is compliant with external and institutional requirements, and extraneous variables are minimized...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28327255/the-interplay-of-ethics-animal-welfare-and-iacuc-oversight-on-the-reproducibility-of-animal-studies
#15
Stacy L Pritt And Robert E Hammer
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experimentswithin the same or among different laboratories. Over the past few years, much has been written and said about the lack of reproducibility of animal studies. Reasons that are commonly cited for this lack of reproducibility include inappropriate study design,errors in conducting the research, and potential fraud. In the quest to understand the basis for this lack of reproducibility, scientists have not fully considered the potential ramifications on ethical constructs for animal research, animal welfare considerations in animal research programs, the regulatory environment, and oversight by IACUCs...
March 21, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28315650/retrospective-analysis-of-reproductive-performance-of-pair-bred-compared-with-trio-bred-mice
#16
Katherine Wasson
Federal guidelines provide recommendations regarding the minimum of floor space that should be allotted for breeding laboratory rodents. Mouse mating systems used by a variety of institutions frequently deviate from these recommendations. Regulatory agencies suggest that deviations from established guidelines should be assessed on an institutional basis and recommend periodic review by the local IACUC. Mouse breeding data, collected in a laboratory animal management software program at a single institution, were retrospectively analyzed to determine the effects of 2 breeding schemes on reproductive performance...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28211866/response-to-protocol-review-scenario-new-procedure-requires-iacuc-review
#17
Deyanira Santiago, Ann Marie Dinkel
No abstract text is available yet for this article.
February 17, 2017: Lab Animal
https://www.readbyqxmd.com/read/28185611/retrospective-analysis-of-reproductive-performance-of-pair-bred-compared-with-trio-bred-mice
#18
Katherine Wasson
Federal guidelines provide recommendations regarding the minimum of floor space that should be allotted for breedinglaboratory rodents. Mouse mating systems used by a variety of institutions frequently deviate from these recommendations.Regulatory agencies suggest that deviations from established guidelines should be assessed on an institutional basis andrecommend periodic review by the local IACUC. Mouse breeding data, collected in a laboratory animal management softwareprogram at a single institution, were retrospectively analyzed to determine the effects of 2 breeding schemes on reproductiveperformance...
February 9, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28165833/diclofenac-sodium-ion-exchange-resin-complex-loaded-melt-cast-films-for-sustained-release-ocular-delivery
#19
Goutham R Adelli, Sai Prachetan Balguri, Prakash Bhagav, Vijayasankar Raman, Soumyajit Majumdar
PURPOSE: The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFSfree) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles, respectively. METHODS: Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFSfree, or a combination of DFSfree + DFS:IR loaded matrix films were prepared by melt-cast technology...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28047827/su-c-204-01-a-dosimetric-investigation-into-the-effects-of-yttrium-90-radioembolization-on-the-gi-tract-in-vivo-and-histological-analysis-in-an-animal-model
#20
A Pasciak, L Nodit, A Bourgeois, B Paxton, A Arepally, Y Bradley
PURPOSE: In Yttrium-90 (90Y) radioembolization, non-target embolization (NTE) to the stomach or small bowel can result in ulceration, a rare but difficult to manage clinical complication. However, dosimetric thresholds for toxicity to these tissues from radioembolization have never been evaluated in a controlled setting. We performed an analysis of the effect of 90Y radioembolization in a porcine model at different absorbed-dose endpoints. METHODS: Under approval of the University of Tennessee IACUC, 6 female pigs were included in this study...
June 2016: Medical Physics
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