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https://www.readbyqxmd.com/read/29456827/impairment-of-social-behaviors-in-arhgef10-knockout-mice
#1
Dai-Hua Lu, Hsiao-Mei Liao, Chia-Hsiang Chen, Huang-Ju Tu, Houng-Chi Liou, Susan Shur-Fen Gau, Wen-Mei Fu
Background: Impaired social interaction is one of the essential features of autism spectrum disorder (ASD). Our previous copy number variation (CNV) study discovered a novel deleted region associated with ASD. One of the genes included in the deleted region is ARHGEF10 . A missense mutation of ARHGEF10 has been reported to be one of the contributing factors in several diseases of the central nervous system. However, the relationship between the loss of ARHGEF10 and the clinical symptoms of ASD is unclear...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29384507/how-should-the-iacuc-handle-unanticipated-deaths
#2
Jerald Silverman
No abstract text is available yet for this article.
January 31, 2018: Lab Animal
https://www.readbyqxmd.com/read/29361508/building-a-simulator-with-life-like-realism-for-teaching-abdominal-operations
#3
James M McGreevy, Jennie M O'Shea
OBJECTIVE: The objective of this communication is to provide an evolutionary description of an attempt to replicate the success of the Rampahl Cardiac Simulator using perfused abdominal organ blocks the way that the Rampahl Simulator uses ex vivo porcine hearts. DESIGN: This descriptive paper makes no attempt to prove the effectiveness of the described educational tool, but rather, outlines the successes and failures in development. The proven value of a perfused organ teaching tool, as the Rampahl Simulator, suggests that others can build upon the work described in this paper so that, in the future, perfused abdominal organs will be available to students of general surgery as a routine part of their pre-operative preparation...
January 17, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29297483/how-should-the-iacuc-handle-a-questionable-vvc-change-to-a-protocol
#4
Jerald Silverman
No abstract text is available yet for this article.
December 29, 2017: Lab Animal
https://www.readbyqxmd.com/read/29077090/response-to-protocol-review-scenario-did-the-iacuc-jump-the-gun
#5
Jenelle Johnson
No abstract text is available yet for this article.
October 27, 2017: Lab Animal
https://www.readbyqxmd.com/read/29077082/how-should-the-iacuc-balance-an-efficient-approval-process-with-minimizing-risk
#6
Jerald Silverman
No abstract text is available yet for this article.
October 27, 2017: Lab Animal
https://www.readbyqxmd.com/read/29033473/impact-of-atra-on-ovalbumin-and-mold-sensitized-f344-rats-and-reversal-of-health-related-implications-by-citral
#7
Ibrahim O Farah, Carlene Holt-Gray, Joseph A Cameron, Michelle Tucci, Hamed Benghuzzi
The role of retinoic acid (All Trans Retinoic Acid; ATRA) in the development of hypervitaminosis A pathophysiology is not well understood or established in the literature. As well, the role of Citral (inhibitor of retinoid function; a non-toxic chemical that exists in two forms (diethyl; C1 or cis-trans dimethyl; C2).) in the reversal of pathophysiological implications is also not ascertained under an in vivo setting. Therefore, it is hypothesized that ovalbumin exposure will sensitize the body to supra-physiologic levels of retinoic acid leading to a negative pathophysiological impact and that Citrals 1 and 2 will reverse or ameliorate the related damage to the body's pathophysiology...
March 2017: Biomedical Sciences Instrumentation
https://www.readbyqxmd.com/read/29033472/histopathological-analysis-of-the-f344-rat-lung-upon-exposure-to-retenoic-acid-ovalbumin-mold-spores-and-citral
#8
Ibrahim O Farah, Carlene Holt-Gray, Joseph A Cameron, Michelle Tucci, Hamed Benghuzzi
The paradoxical role of retinoic acid (All Trans Retinoic Acid; ATRA) in the development of allergic and/or inflammatory complications in contrast to a therapeutic modality for lung pathology is not well understood or established in the literature. As well, the role of Citral (inhibitor of retinoid function; a non-toxic chemical that exists in two forms (diethyl; C1 or cis-trans dimethyl; C2), in the reversal of retinoic acid, ovalbumin and allergic mold spore pathophysiology is also not well ascertained under an in vivo setting...
March 2017: Biomedical Sciences Instrumentation
https://www.readbyqxmd.com/read/28984851/two-major-survival-surgeries-one-protocol-how-should-the-iacuc-report-violations-and-change-practices
#9
Jerald Silverman
No abstract text is available yet for this article.
October 6, 2017: Lab Animal
https://www.readbyqxmd.com/read/28955711/environmental-and-physiological-factors-associated-with-stamina-in-dogs-exercising-in-high-ambient-temperatures
#10
Patrick J Robbins, Meghan T Ramos, Brian M Zanghi, Cynthia M Otto
This IACUC approved study was performed to evaluate the environmental, physiological, and hematological components that contribute to stamina following successive bouts of exercise that included searching (5-min), agility (5-min), and ball retrieve (<10-min). Regularly exercised dogs (N = 12) were evaluated on five separate occasions. The population consisted of eight males and four females ranging in age from 8 to 23 months, which included six Labrador retrievers, three German shepherds, and one each English springer spaniel, German wirehaired pointer, and Dutch shepherd...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28954551/heat-stress-induced-ligand-independent-met-and-egfr-signaling-in-hepatocellular-carcinoma
#11
Scott M Thompson, Danielle E Jondal, Kim A Butters, Bruce E Knudsen, Jill L Anderson, Matthew P Stokes, Xiaoying Jia, Joseph P Grande, Lewis R Roberts, Matthew R Callstrom, David A Woodrum
PURPOSE: The aims of the present study were two-fold: first, to test the hypothesis that heat stress induces MET and EGFR signaling in hepatocellular carcinoma (HCC) cells and inhibition of this signaling decreases HCC clonogenic survival; and second, to identify signaling pathways associated with heat-stress induced MET signaling. MATERIALS AND METHODS: MET(+) and EGFR(+) HCC cells were pre-treated with inhibitors to MET, EGFR, PI3K/mTOR or vehicle and subjected to heat stress or control ± HGF or EGF growth factors and assessed by colony formation assay, Western blotting and/or quantitative mass spectrometry...
September 27, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28948399/interventional-magnetic-resonance-imaging-guided-carotid-embolectomy-using-a-novel-resonant-marker-catheter-demonstration-of-preclinical-feasibility
#12
Jeffrey K Yang, Andre M Cote, Caroline D Jordan, Sravani Kondapavulur, Aaron D Losey, David McCoy, Andrew Chu, Jay F Yu, Teri Moore, Carol Stillson, Fabio Settecase, Matthew D Alexander, Andrew Nicholson, Daniel L Cooke, Maythem Saeed, Dave Barry, Alastair J Martin, Mark W Wilson, Steven W Hetts
To assess the visualization and efficacy of a wireless resonant circuit (wRC) catheter system for carotid artery occlusion and embolectomy under real-time MRI guidance in vivo, and to compare MR imaging modality with x-ray for analysis of qualitative physiological measures of blood flow at baseline and after embolectomy. The wRC catheter system was constructed using a MR compatible PEEK fiber braided catheter (Penumbra, Inc, Alameda, CA) with a single insulated longitudinal copper loop soldered to a printed circuit board embedded within the catheter wall...
September 25, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28935005/sequelae-of-occult-aggression-disqualifying-young-socially-housed-female-new-zealand-white-rabbits-oryctolagus-cuniculus-from-participation-in-dermal-toxicology-studies
#13
Jeffrey D Wyatt, Diane M Moorman-White, Donnalee Ventura, Brett W Schneider, Thomas W Bittner
International animal welfare organizations and federal, regional, and institutional oversight bodies encourage social housing of gregarious species, such as New Zealand white rabbits (Oryctolagus cuniculus), to promote animal wellbeing in research, teaching, testing and farming settings. At our institution, 2 groups of female New Zealand white rabbits (approximate age, 11 wk; mean weight, 2.35 kg), compatibly paired at the vendor for 5 wk, were paired in caging or group-housed in a floor pen. The rabbits appeared compatible, demonstrating primarily affiliative behaviors throughout 6 wk of daily observations...
October 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28916246/pre-clinical-toxicology-considerations-for-vaccine-development
#14
REVIEW
Nabil Al-Humadi
Vaccine development requires pre-clinical toxicology studies, following good laboratory practice (GLP), before first in human (phase I) use. Many factors are critical in the final outcome of any pre-clinical toxicology study. The study design is one of these critical factors and should be carefully planned to avoid any false negative and/or false positive results. Preparation is another most critical factor in a successful study. Major changes in any procedure during the course of study should be avoided by all means...
September 12, 2017: Vaccine
https://www.readbyqxmd.com/read/28903820/considerations-when-writing-and-reviewing-a-higher-education-teaching-protocol-involving-animals
#15
Tracy H Vemulapalli, Shawn S Donkin, Timothy B Lescun, Peggy A O'Neil, Patrick A Zollner
The targeted use of animals in teaching at institutions of higher learning is fundamental to educating the next generation of professionals in the biologic and animal sciences. As with animal research, universities and colleges that use animals in teaching are subject to regulatory oversight. Instructors must receive approval from their IACUC before using animals in their teaching. However, the questions asked on many institutions' animal care and use protocol (ACUP) are often geared more toward the use of animals for research...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28838070/the-role-of-the-iacuc-in-the-design-and-conduct-of-animal-experiments-that-contribute-to-translational-success
#16
J I Everitt, B R Berridge
Institutional Animal Care and Use Committees (IACUCs) have a mandated role under the Animal Welfare Act and under Public Health Service Policy to assure the ethical and humane use of research animals in experiments conducted in the United States. The IACUC by virtue of its mandated functions is well positioned to help nurture an institutional culture of optimized animal use since this Committee is often responsible in large part for the culture of animal use that evolves within an institution. In addition to fostering a culture of humane care for research animals and a culture of working with the concepts of the 3Rs (refinement, reduction, replacement), the IACUC can help foster a culture of optimized animal use that encourages high quality reproducible studies that contribute to translational success...
July 1, 2017: ILAR Journal
https://www.readbyqxmd.com/read/28821637/ensuring-due-process-in-the-iacuc-and-animal-welfare-setting-considerations-in-developing-noncompliance-policies-and-procedures-for-institutional-animal-care-and-use-committees-and-institutional-officials
#17
REVIEW
Barbara C Hansen, Sylvia Gografe, Stacy Pritt, Kai-Lin Catherine Jen, Camille A McWhirter, Susan M Barman, Anthony Comuzzie, Molly Greene, Justin A McNulty, Daniel Eugene Michele, Naz Moaddab, Randall J Nelson, Karen Norris, Karen D Uray, Ron Banks, Karin N Westlund, Bill J Yates, Jerald Silverman, Kenneth D Hansen, Barbara Redman
Every institution that is involved in research with animals is expected to have in place policies and procedures for the management of allegations of noncompliance with the Animal Welfare Act and the U.S. Public Health Service Policy on the Humane Care and Use of Laboratory Animals. We present here a model set of recommendations for institutional animal care and use committees and institutional officials to ensure appropriate consideration of allegations of noncompliance with federal Animal Welfare Act regulations that carry a significant risk or specific threat to animal welfare...
October 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28660807/factors-influencing-iacuc-decision-making-who-leads-the-discussions
#18
Jerald Silverman, Charles W Lidz, Jonathan Clayfield, Alexandra Murray, Lorna J Simon, Louise Maranda
Decisions about the appropriate use of animals in research are largely made by Institutional Animal Care and Use Committees (IACUCs). Several commentators claim that scientists exert excessive influence on IACUC decisions. We studied 87 protocol reviews from 10 IACUCs to assess whether any group of participants appeared to dominate the protocol discussions. Audio recordings of the meetings were coded to capture the topics of the discussions. We found that animal research scientists made the largest total number of topic mentions while community members made the fewest...
October 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28644459/what-does-reporting-to-the-iacuc-mean-for-pam
#19
Jerald Silverman
No abstract text is available yet for this article.
June 23, 2017: Lab Animal
https://www.readbyqxmd.com/read/28617531/controlled-release-mitomycin-c-polylactic-acid-film-prevents-epidural-scar-hyperplasia-after-laminectomy-by-inducing-fibroblast-autophagy-and-regulating-the-expression-of-mirnas
#20
B-B Wang, H Xie, T Wu, N Xie, J Wu, Y Gu, F Tang, J Liu
OBJECTIVE: To design a new controlled-release MMC-PLA film and explore whether and how this film could prevent epidural scar hyperplasia and adhesion in a post-laminectomy rat model. MATERIALS AND METHODS: All procedures were performed under the approval and supervision of the Institutional Animal Care and Use Committee (IACUC) of Nanjing Medical University. A total of 120 Sprague-Dawley (SD) rats were randomly placed into four groups after laminectomy (each group=30 rats)...
May 2017: European Review for Medical and Pharmacological Sciences
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