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https://www.readbyqxmd.com/read/28422105/what-role-should-an-iacuc-play-when-a-pi-s-manuscript-is-on-the-line
#1
Jerald Silverman
No abstract text is available yet for this article.
April 19, 2017: Lab Animal
https://www.readbyqxmd.com/read/28382685/dimethyl-fumarate-ameliorates-myoclonus-stemming-from-protein-misfolding-in-oligodendrocytes
#2
Cherie M Southwood, Danielle M Garshott, Chelsea R Richardson, Navid Seraji-Bozorgzad, Andrew M Fribley, Alexander Gow
Multiple sclerosis (MS) is considered a primary autoimmune disease; however, this view is increasingly being challenged in basic and clinical science arenas because of the growing body of clinical trials data showing that exclusion of immune cells from the CNS only modestly slows disease progression to disability. Accordingly, there is significant need for expanding the scope of potential disease mechanisms to understand the etiology of MS. Concomitantly, the use of a broader range of preclinical animal models for characterizing existing efficacious clinical treatments may elucidate additional or unexpected mechanisms of action for these drugs that augment insight into MS etiology...
April 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28381309/the-interplay-of-ethics-animal-welfare-and-iacuc-oversight-on-the-reproducibility-of-animal-studies
#3
Stacy L Pritt, Robert E Hammer
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experiments within the same or among different laboratories. Over the past few years, much has been written and said about the lack of reproducibility of animal studies. Reasons that are commonly cited for this lack of reproducibility include inappropriate study design, errors in conducting the research, and potential fraud. In the quest to understand the basis for this lack of reproducibility, scientists have not fully considered the potential ramifications on ethical constructs for animal research, animal welfare considerations in animal research programs, the regulatory environment, and oversight by IACUCs...
March 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28328872/the-role-of-the-iacuc-in-ensuring-research-reproducibility
#4
REVIEW
Jerald Silverman, James Macy, Patricia A Preisig
There is a "village" of people impacting research reproducibility, such as funding panels, the IACUC and its support staff, institutional leaders, investigators, veterinarians, animal facilities, and professional journals. IACUCs can contribute to research reproducibility by ensuring that reviews of animal use requests, program self-assessments and post-approval monitoring programs are sufficiently thorough, the animal model is appropriate for testing the hypothesis, animal care and use is conducted in a manner that is compliant with external and institutional requirements, and extraneous variables are minimized...
March 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28327255/the-interplay-of-ethics-animal-welfare-and-iacuc-oversight-on-the-reproducibility-of-animal-studies
#5
Stacy L Pritt And Robert E Hammer
Reproducibility in animal studies has been defined as the ability of a result to be replicated through independent experimentswithin the same or among different laboratories. Over the past few years, much has been written and said about the lack of reproducibility of animal studies. Reasons that are commonly cited for this lack of reproducibility include inappropriate study design,errors in conducting the research, and potential fraud. In the quest to understand the basis for this lack of reproducibility, scientists have not fully considered the potential ramifications on ethical constructs for animal research, animal welfare considerations in animal research programs, the regulatory environment, and oversight by IACUCs...
March 21, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28315650/retrospective-analysis-of-reproductive-performance-of-pair-bred-compared-with-trio-bred-mice
#6
Katherine Wasson
Federal guidelines provide recommendations regarding the minimum of floor space that should be allotted for breeding laboratory rodents. Mouse mating systems used by a variety of institutions frequently deviate from these recommendations. Regulatory agencies suggest that deviations from established guidelines should be assessed on an institutional basis and recommend periodic review by the local IACUC. Mouse breeding data, collected in a laboratory animal management software program at a single institution, were retrospectively analyzed to determine the effects of 2 breeding schemes on reproductive performance...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28211866/response-to-protocol-review-scenario-new-procedure-requires-iacuc-review
#7
Deyanira Santiago, Ann Marie Dinkel
No abstract text is available yet for this article.
February 17, 2017: Lab Animal
https://www.readbyqxmd.com/read/28185611/retrospective-analysis-of-reproductive-performance-of-pair-bred-compared-with-trio-bred-mice
#8
Katherine Wasson
Federal guidelines provide recommendations regarding the minimum of floor space that should be allotted for breedinglaboratory rodents. Mouse mating systems used by a variety of institutions frequently deviate from these recommendations.Regulatory agencies suggest that deviations from established guidelines should be assessed on an institutional basis andrecommend periodic review by the local IACUC. Mouse breeding data, collected in a laboratory animal management softwareprogram at a single institution, were retrospectively analyzed to determine the effects of 2 breeding schemes on reproductiveperformance...
February 9, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28165833/diclofenac-sodium-ion-exchange-resin-complex-loaded-melt-cast-films-for-sustained-release-ocular-delivery
#9
Goutham R Adelli, Sai Prachetan Balguri, Prakash Bhagav, Vijayasankar Raman, Soumyajit Majumdar
PURPOSE: The goal of the present study is to develop polymeric matrix films loaded with a combination of free diclofenac sodium (DFSfree) and DFS:Ion exchange resin complexes (DFS:IR) for immediate and sustained release profiles, respectively. METHODS: Effect of ratio of DFS and IR on the DFS:IR complexation efficiency was studied using batch processing. DFS:IR complex, DFSfree, or a combination of DFSfree + DFS:IR loaded matrix films were prepared by melt-cast technology...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28047827/su-c-204-01-a-dosimetric-investigation-into-the-effects-of-yttrium-90-radioembolization-on-the-gi-tract-in-vivo-and-histological-analysis-in-an-animal-model
#10
A Pasciak, L Nodit, A Bourgeois, B Paxton, A Arepally, Y Bradley
PURPOSE: In Yttrium-90 (90Y) radioembolization, non-target embolization (NTE) to the stomach or small bowel can result in ulceration, a rare but difficult to manage clinical complication. However, dosimetric thresholds for toxicity to these tissues from radioembolization have never been evaluated in a controlled setting. We performed an analysis of the effect of 90Y radioembolization in a porcine model at different absorbed-dose endpoints. METHODS: Under approval of the University of Tennessee IACUC, 6 female pigs were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047017/su-c-204-07-radiation-therapy-as-a-potential-treatment-for-obesity-initial-data-from-a-preclinical-investigation
#11
A Pasciak, Y Bradley, L Nodit, A Bourgeois, B Paxton, A Arepally
PURPOSE: To evaluate the feasibility of Yttrium-90 (90Y) radionuclide therapy as a potential treatment for obesity in a porcine model. As the only appetite-stimulating hormone, localized targeting of ghrelin-producing X/A cells in the fundus of the stomach using 90Y may reduce serum ghrelin levels and decrease hunger. METHODS: Under approval of the University of Tennessee IACUC, 8 young female pigs aged 12-13 weeks and weighing 21.8-28.1 Kg were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046891/we-fg-206-12-enhanced-laws-textures-a-potential-mri-surrogate-marker-of-hepatic-fibrosis-in-a-murine-model
#12
B Li, H Yu, H Jara, J Soto, S Anderson
PURPOSE: To compare enhanced Laws texture derived from parametric proton density (PD) maps to other MRI-based surrogate markers (T2, PD, ADC) in assessing degrees of liver fibrosis in a murine model of hepatic fibrosis using 11.7T scanner. METHODS: This animal study was IACUC approved. Fourteen mice were divided into control (n=1) and experimental (n=13). The latter were fed a DDC-supplemented diet to induce hepatic fibrosis. Liver specimens were imaged using an 11...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27991869/terminal-procedures-should-an-iacuc-require-a-literature-review-for-less-painful-alternatives
#13
Jerald Silverman
No abstract text is available yet for this article.
December 19, 2016: Lab Animal
https://www.readbyqxmd.com/read/27856399/enhanced-laws-textures-a-potential-mri-surrogate-marker-of-hepatic-fibrosis-in-a-murine-model
#14
Baojun Li, Hernan Jara, Heishun Yu, Michael O'Brien, Jorge Soto, Stephan W Anderson
PURPOSE: To compare enhanced Laws textures derived from parametric proton density (PD) maps to other MRI surrogate markers (T2, PD, apparent diffusion coefficient (ADC)) in assessing degrees of liver fibrosis in an ex vivo murine model of hepatic fibrosis imaged using 11.7T MRI. METHODS: This animal study was IACUC approved. Fourteen male, C57BL/6 mice were divided into control and experimental groups. The latter were fed a 3,5-dicarbethoxy-1,4-dihydrocollidine (DDC) supplemented diet to induce hepatic fibrosis...
November 14, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27716434/oestrogen-induced-angiogenesis-and-implantation-contribute-to-the-development-of-parasitic-myomas-after-laparoscopic-morcellation
#15
Ben-Shian Huang, Muh-Hwa Yang, Peng-Hui Wang, Hsin-Yang Li, Teh-Ying Chou, Yi-Jen Chen
BACKGROUND: Iatrogenic parasitic myomas (PMs), caused by intra-corporeal power morcellation during laparoscopy is gradually increasing. However, the pathogenesis and medical treatment of PMs remain largely unelucidated. METHODS: Laparoscopically-induced PM xenografted mouse model was conducted by xenografting human uterine myoma fragments into the abdominal cavity of SCID mice and hormonal manipulation was performed using this mouse model to demonstrate the role of oestrogen in the development of implanted PMs...
October 6, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27664339/quiescent-pluripotent-stem-cells-reside-within-murine-peripheral-nerves-that-can-be-stimulated-to-proliferate-by-recombinant-human-bone-morphogenic-protein-2-or-by-nerve-trauma
#16
Michael H Heggeness, Nora Strong, Paul H Wooley, Shang-You Yang
BACKGROUND: The clinical use of recombinant human bone morphogenic protein 2 (rhBMP-2, Infuse) has been associated with nerve-related complications including new-onset sciatica, and retrograde ejaculation. PURPOSE: To better understand the interaction of rhBMP-2 and peripheral nerves with the intent of making procedures safer. STUDY DESIGN/SETTING: Using a mouse model to examine the direct effect of diluted rhBMP-2 (Infuse) on murine sciatic nerves...
September 21, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27606820/lapse-in-institutional-animal-care-and-use-committee-continuing-reviews
#17
Min-Fu Tsan, Michael Grabenbauer, Yen Nguyen
The United States federal animal welfare regulations and the Public Health Service Policy on Humane Care and Use of Laboratory Animals require that institutional animal care and use committees (IACUCs) conduct continuing reviews of all animal research activities. However, little is known about the lapse rate of IACUC continuing reviews, and how frequently investigators continue research activities during the lapse. It is also not clear what factors may contribute to an institution's lapse in IACUC continuing reviews...
2016: PloS One
https://www.readbyqxmd.com/read/27584043/an-orthotopic-mouse-model-of-spontaneous-breast-cancer-metastasis
#18
Amy V Paschall, Kebin Liu
Metastasis is the primary cause of mortality of breast cancer patients. The mechanism underlying cancer cell metastasis, including breast cancer metastasis, is largely unknown and is a focus in cancer research. Various breast cancer spontaneous metastasis mouse models have been established. Here, we report a simplified procedure to establish orthotopic transplanted breast cancer primary tumor and resultant spontaneous metastasis that mimic human breast cancer metastasis. Combined with the bioluminescence live tumor imaging, this mouse model allows tumor growth and progression kinetics to be monitored and quantified...
August 14, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27551798/what-are-the-limits-of-confidentiality-for-iacuc-members
#19
Jerald Silverman
No abstract text is available yet for this article.
August 23, 2016: Lab Animal
https://www.readbyqxmd.com/read/27501853/pilot-trial-of-intravenous-lipid-emulsion-treatment-for-severe-nifedipine-induced-shock
#20
Christine M Murphy, Cliff Williams, Michael E Quinn, Brian Nicholson, Thomas Shoe, Michael C Beuhler, William P Kerns
Animal studies and human case reports show promise in using lipid rescue to treat refractory calcium channel antagonist toxicity. However, the majority of research and clinical experience has focused on non-dihydropyridine agents. Thus, we sought to investigate the value of lipid emulsion (ILE) therapy for dihydropyridine-induced shock. This IACUC-approved study utilized seven swine that were sedated with alpha-chloralose, mechanically ventilated, and instrumented for drug delivery and hemodynamic measures...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
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