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Oedema management

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https://www.readbyqxmd.com/read/29755555/the-ethanolic-extract-of-eysenhardtia-polystachya-ort-sarg-bark-and-its-fractions-delay-the-progression-of-rheumatoid-arthritis-and-show-antinociceptive-activity-in-murine-models
#1
Saudy Saret Pablo-Pérez, Benjamín Parada-Cruz, Olivier Christophe Barbier, María Estela Meléndez-Camargo
Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesic agent, but no systematic study of its effects on several markers associated with rheumatoid arthritis and its ethnomedical use as analgesic agent has been performed. We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. The EE was administered orally at doses of 25, 50, 100, and 200 mg/kg/day, and its fractions at 25 mg/kg/day in all animal models...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29736690/osthole-ameliorates-neurogenic-and-inflammatory-hyperalgesia-by-modulation-of-inos-cox-2-and-inflammatory-cytokines-in-mice
#2
Gurjit Singh, Rajbir Bhatti, Rahul Mannan, Drishtant Singh, Anup Kesavan, Palwinder Singh
BACKGROUND: Osthole is a bioactive component reported in medicinal plants such as Angelica pubescens and Cnidium monnieri, known for analgesic activity. However, the toxicity, median effective dose (ED50 ), and dual modulation of nitric oxide and cyclooxygenase pathways along with inflammatory cytokines of osthole are yet to be determined. METHODS: The animals (mice) were assessed for general behaviour and mortality in varying doses (50, 300, and 2000 mg kg-1 ) of osthole for acute toxicity over 14 days...
May 7, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29729466/calcifying-pseudoneoplasm-of-the-neuraxis-capnon-a-case-illustrating-natural-history-over-17-years-of-radiological-surveillance
#3
Sean M Barber, Jacob Chen Ming Low, Paul Johns, Philip Rich, Bridget MacDonald, Timothy L Jones
Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare central nervous system (CNS) lesion that can be found in both the brain and the spine. Although this entity is poorly understood, radiological and histological features have been identified. We describe a unique case of a 31-year-old patient who was managed with anti-epileptic medication for 17 years before requiring neurosurgical intervention for tumour progression. T2-weighted MRI revealed hyperintensity within the tumour with extensive associated vasogenic oedema, which is not normally associated with CAPNON...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29705892/the-ophthalmic-diagnosis-and-management-of-four-siblings-with-werner-syndrome
#4
C Lyons, D Gallagher, T McSwiney, E McElnea, F Kinsella
INTRODUCTION: Werner syndrome is a rare autosomal recessive disorder caused by mutations in the Werner syndrome WRN gene, on chromosome 8. Those affected manifest early the features of ageing. DISCUSSION: Cataract surgery is prone to post-operative complications in those with Werner syndrome. The development of cystoid macular oedema (CMO) is likely multifactorial. Patients with WS have diabetes mellitus type 2 which can contribute to macular oedema. There is a deposition of abnormal WRN proteins in the macula which also predisposes to macular oedema...
April 28, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29700086/hyperacute-management-of-intracerebral-haemorrhage
#5
Kyriaki Paroutoglou, Adrian R Parry-Jones
Intracerebral haemorrhage causes 1 in 10 strokes, but has the worst overall outcomes of all stroke subtypes. Baseline haematoma volume is a key prognostic factor and early complications - such as haematoma expansion, obstructive hydrocephalus and perihaematomal oedema - may worsen outcome. There is evidence that withdrawal of care may occur more often in intracerebral haemorrhage than ischaemic stroke independent of premorbid health and stroke severity. However, recent evidence shows that reversal of anticoagulants, intensive blood pressure lowering and surgery in carefully selected cases may improve outcomes...
April 1, 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29691755/my-patient-has-received-fluid-how-to-assess-its-efficacy-and-side-effects
#6
REVIEW
Xavier Monnet, Jean-Louis Teboul
Many efforts have been made to predict, before giving fluid, whether it will increase cardiac output. Nevertheless, after fluid administration, it is also essential to assess the therapeutic efficacy and to look for possible adverse effects. Like for any drug, this step should not be missed. Basically, volume expansion is aimed at improving tissue oxygenation and organ function. To assess this final result, clinical signs are often unhelpful. The increase in urine output in case of acute kidney injury is a poor marker of the kidney perfusion improvement...
April 24, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29690916/combined-protocol-for-acute-malnutrition-study-compas-in-rural-south-sudan-and-urban-kenya-study-protocol-for-a-randomized-controlled-trial
#7
Jeanette Bailey, Natasha Lelijveld, Bethany Marron, Pamela Onyoo, Lara S Ho, Mark Manary, André Briend, Charles Opondo, Marko Kerac
BACKGROUND: Acute malnutrition is a continuum condition, but severe and moderate forms are treated separately, with different protocols and therapeutic products, managed by separate United Nations agencies. The Combined Protocol for Acute Malnutrition Study (ComPAS) aims to simplify and unify the treatment of uncomplicated severe and moderate acute malnutrition (SAM and MAM) for children 6-59 months into one protocol in order to improve the global coverage, quality, continuity of care and cost-effectiveness of acute malnutrition treatment in resource-constrained settings...
April 24, 2018: Trials
https://www.readbyqxmd.com/read/29686958/temporal-lobe-cystic-collection-and-associated-oedema-a-rare-complication-of-translabyrinthine-resection-of-vestibular-schwannoma
#8
Abdurrahman Raeiq
Vestibular schwannomas (VS) are benign tumours arising from the vestibulocochlear nerve. Among the management options available, surgical resection is often considered, especially if lesions are enlarging or symptomatic. Translabyrinthine (TL) resection of a vestibular schwannoma is one of three basic approaches available to the surgeon. Complications generally associated with this approach can include cerebrospinal fluid (CSF) leak, hearing and balance issues, infection, and facial nerve palsies. We present the case of a patient with a previously unreported type of complication: that of cystic CSF collection within the temporal lobe and associated oedema...
February 21, 2018: Curēus
https://www.readbyqxmd.com/read/29680750/complete-resection-of-hypervascularised-extraventricular-neurocytoma-after-preoperative-embolisation
#9
Majed Katati, Isabel García, Clara Isabel Chamorro, Ángel Horcajadas, Alicia Hurtado, Carlos Sánchez, Benjamín Iañez, Enrique Saura, Ernesto García, Heriberto Busquier
A 13-year-old female arrived at the Emergency Department with a two-week history of headache, and bilateral papilloedema on examination. The initial study with CT and MRI showed a large multicystic left frontal mass with calcification surrounded by peripheral oedema, subacute intralesional bleeding and association of multiple large vessels. She was initially operated on in another centre where a subacute haematoma was found, evacuating to multiple vessels and arteriolised veins. Despite the earlier neuroimaging findings, arteriovenous malformation (AVM) was suspected, so she was referred to our centre for further treatment...
April 18, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29678205/management-of-severe-acute-malnutrition-by-cow-milk-in-resource-constraints-settings-experience-of-the-nutritional-centre-of-the-university-clinics-of-graben
#10
Mupenzi Mumbere, F Katsuva Mbahweka, B P Furaha Nzanzu
BACKGROUND: Severe acute malnutrition is defined as a weight for height z-score < - 3 standard deviation. Since 2000, joint efforts of the World Health Organization and United Nations Children's Fund allowed to standardize the management of acute malnutrition by improving outcome and preventing complications with the introduction of therapeutic milk and ready-to-use therapeutic foods. However, in the Democratic Republic of Congo, many health facilities face therapeutic milk shortage while managing severe acute malnutrition...
April 20, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29669176/anti-vascular-endothelial-growth-factor-combined-with-intravitreal-steroids-for-diabetic-macular-oedema
#11
REVIEW
Hemal Mehta, Charles Hennings, Mark C Gillies, Vuong Nguyen, Anna Campain, Samantha Fraser-Bell
BACKGROUND: The combination of steroid and anti-vascular endothelial growth factor (VEGF) intravitreal therapeutic agents could potentially have synergistic effects for treating diabetic macular oedema (DMO). On the one hand, if combined treatment is more effective than monotherapy, there would be significant implications for improving patient outcomes. Conversely, if there is no added benefit of combination therapy, then people could be potentially exposed to unnecessary local or systemic side effects...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29657976/efficacy-of-additional-topical-betamethasone-in-persistent-cystoid-macular-oedema-after-carbonic-anhydrase-inhibitor-treatments-in-retinitis-pigmentosa
#12
Shohei Kitahata, Yasuhiko Hirami, Seiji Takagi, Cody Kime, Masashi Fujihara, Yasuo Kurimoto, Masayo Takahashi
Objective: We investigated the efficacy of additional topical betamethasone in persistent cystoid macular oedema (CMO) after carbonic anhydrase inhibitors (CAIs) therapy. Methods and analysis: This retrospective cohort study included 16 eyes of 10 patients with retinitis pigmentosa (RP). All patients were previously administered CAI for at least 3 months to treat CMO secondary to RP and lacking an effective reduction (≥11%) of central foveal thickness (CFT)...
2018: BMJ Open Ophthalmology
https://www.readbyqxmd.com/read/29657718/endotracheal-tube-clamping-and-extracorporeal-membrane-oxygenation-to-resuscitate-massive-pulmonary-haemorrhage
#13
Chien-Feng Lee, Chun-Ta Huang, Sheng-Yuan Ruan
Massive pulmonary haemorrhage is a life-threatening and difficult-to-manage condition. In certain circumstances, traditional approaches for haemoptysis may not be effective. Here, we report a 64-year-old man presenting with dyspnoea and leg oedema. He was diagnosed with microscopic polyangiitis due to positive perinuclear anti-neutrophil cytoplasmic antibody and other supportive evidence. His hospital course was complicated with massive pulmonary haemorrhage, which led to hypoxic respiratory failure, shock, and pulseless electrical activity...
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29629674/life-threatening-hereditary-angio-oedema-challenges-of-care-in-south-africa
#14
P Potter, J Peter
The report and description by Coovadia et al.[1] in this issue of SAMJ of a large cohort of patients in the Western Cape Province of South Africa (SA) suffering from type 1 hereditary angio-oedema (HAE) not only documents for the first time a significant presence of this life-threatening condition on the African continent but highlights the challenges of diagnosis and management in the SA socioeconomic and healthcare context.
March 28, 2018: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29616496/how-to-use-the-kaiser-score-as-a-clinical-decision-rule-for-diagnosis-in-multiparametric-breast-mri-a-pictorial-essay
#15
REVIEW
Matthias Dietzel, Pascal A T Baltzer
Due to its superior sensitivity, breast MRI (bMRI) has been established as an important additional diagnostic tool in the breast clinic and is used for screening in patients with an elevated risk for breast cancer. Breast MRI, however, is a complex tool, providing multiple images containing several contrasts. Thus, reading bMRI requires a structured approach. A lack of structure will increase the rate of false-positive findings and sacrifice most of the advantages of bMRI as additional work-up will be required...
April 3, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29594463/traumatic-brain-injury-in-indian-children
#16
REVIEW
Krishna Chaitanya, Archana Addanki, Rajendra Karambelkar, Rakesh Ranjan
INTRODUCTION: Traumatic brain injury (TBI) in children and adolescents is a community-based medical and educational challenge world-over due to increasing urbanization and motorization. In India, children between 1 to 15 years constitute significant proportion of the total population, who are vulnerable for TBI. In developed countries, pediatric trauma mortality still represents more than half of all childhood fatalities, which is 18 times more common than brain tumors. In this study, we attempted to analyze epidemiological factors, management, and outcome of TBI in children at a tertiary care center in Pune, Maharashtra...
March 29, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29564804/management-of-complications-of-cosmetic-iris-implants-in-a-phakic-eye-a-case-report-and-literature-review
#17
Millicent Bore, Nikhil Choudhari, Sunita Chaurasia
PURPOSE: To report the intricacies of managing complications that arose out of cosmetic iris implants (BrightOcular) placement. DESIGN: Interventional case report. METHODS: A thirty-year-old gentleman presented with complaint of progressive loss of vision after having cosmetic iris implant surgery to change his eye colour. He then developed raised intraocular pressures and had a right eye trabeculectomy conducted with the implants in situ...
March 21, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29563110/clinical-features-of-patients-with-diabetic-anterior-uveitis
#18
Takayo Watanabe, Hiroshi Keino, Kyoko Nakayama, Wakako Taki, Nariaki Echizen, Annabelle A Okada
AIM: To describe clinical features and outcomes of new-onset anterior uveitis associated with poorly controlled or undiagnosed diabetes mellitus. METHODS: Retrospective analysis of 25 eyes of 18 patients (14 men, 4 women; mean age 44 years) who presented between December 2001 and October 2016 to the Kyorin Eye Center. RESULTS: Ocular findings at presentation included posterior synechiae (15 eyes, 60%), anterior chamber fibrin (13 eyes, 52%), keratic precipitates (10 eyes, 40%), Descemet membrane folds (7 eyes, 28%) and hypopyon (3 eyes, 12%)...
March 21, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29561260/the-effect-of-corticosteroid-versus-platelet-rich-plasma-injection-therapies-for-the-management-of-lateral-epicondylitis-a-systematic-review
#19
Walid Ben-Nafa, Wendy Munro
INTRODUCTION: Lateral epicondylitis is a common musculoskeletal disorder of the upper limb. Corticosteroid injection has been widely used as a major mode of treatment. However, better understanding of the pathophysiology of the disease led to a major change in treating the disease, with new options including platelet-rich plasma (PRP) are currently used. Objectives/research aim: To systematically evaluate the effect of corticosteroid versus PRP injections for the treatment of LE. HYPOTHESIS: PRP injections provide longer-term therapeutic effect and less rate of complications compared to corticosteroid injection...
2018: SICOT-J
https://www.readbyqxmd.com/read/29535477/hyponatraemia-in-hospitalised-adults-a-guide-for-the-junior-doctor
#20
Joseph Fogarty, Clodagh Loughrey
Hyponatraemia is common and often a source of confusion for junior doctors. It is infrequently dangerous, but when it is, is a medical emergency and requires urgent treatment to avoid life-threatening cerebral oedema. Treatment of acute hyponatraemia is also potentially hazardous; it is therefore important to be able to recognise when urgent management is not indicated, and to investigate appropriately. This paper focuses on these issues, which are most likely to be the cause of consternation for the junior doctor...
May 2017: Ulster Medical Journal
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