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Burn outcome measures

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https://www.readbyqxmd.com/read/29141906/keratolimbal-allograft-for-limbal-stem-cell-deficiency-after-severe-corneal-chemical-injury-a-systematic-review
#1
Swapna S Shanbhag, Hajirah N Saeed, Eleftherios I Paschalis, James Chodosh
PURPOSE: To review the published literature on outcomes of keratolimbal allograft (KLAL) for the surgical treatment of limbal stem cell deficiency (LSCD) and corneal blindness after severe corneal chemical injury. METHODS: Literature searches were conducted in the following electronic databases: MEDLINE, EMBASE, Science Citation Index, CINAHL, LILACS and the Cochrane Library. Standard systematic review methodology was applied. The main outcome measure was the proportion of eyes with best-corrected visual acuity (BCVA) ≥20/200 at last follow-up...
November 15, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29141183/functional-outcomes-of-acute-inpatient-rehabilitation-in-patients-with-chronic-graft-versus-host-disease
#2
Jason Leung, Sean Smith, Claire Kalpakjian
BACKGROUND: Growing numbers of allogeneic stem cell transplants (HSCT) and improved post-transplant care have led to an increase of individuals with chronic graft versus host disease (cGVHD). Although cGVHD leads to functional impairment for many, there is limited literature regarding the benefits of acute inpatient rehabilitation for cGVHD patients. OBJECTIVE: To assess Functional Independence Measure (FIM) outcomes of cGVHD patients during acute inpatient rehabilitation, and to compare inpatient rehabilitation outcomes to burn patients, a rehabilitation patient population with similar co-morbidities...
November 12, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29140950/development-of-clinical-process-measures-for-pediatric-burn-care-understanding-variation-in-practice-patterns
#3
Lewis E Kazis, Robert L Sheridan, Gabriel D Shapiro, Austin F Lee, Matthew H Liang, Colleen M Ryan, Jeffrey C Schneider, Martha Lydon, Marina Soley-Bori, Lily A Sonis, Emily C Dore, Tina Palmieri, David Herndon, Walter Meyer, Petra Warner, Richard Kagan, Frederick J Stoddard, Michael Murphy, Ronald G Tompkins
BACKGROUND: There has been little systematic examination of variation in pediatric burn care clinical practices and its effect on outcomes. As a first step, current clinical care processes need to be operationally defined. The highly specialized burn care units of the Shriners Hospitals for Children system present an opportunity to describe the processes of care. The aim of this study was to develop a set of process-based measures for pediatric burn care and examine adherence to them by providers in a cohort of pediatric burn patients...
November 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29138224/short-term-metformin-and-exercise-training-effects-on-strength-aerobic-capacity-glycemic-control-and-mitochondrial-function-in-children-with-burn-injury
#4
Eric Rivas, David N Herndon, Craig Porter, Walter Meyer, Oscar E Suman
Severely burned children experience a chronic state of sympathetic nervous system activation that is associated with hypermetabolic/cardiac stress and muscle wasting. Metformin, a diabetes medication, helps control hyperglycemia in diabetic populations, and exercise has been shown to improve exercise strength and aerobic exercise capacity after severe burns. However, whether exercise improves glycemic control in burned children and whether combining exercise and metformin improves outcomes to a greater degree than exercise alone is unknown...
November 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29121988/efficacy-of-banha-sasim-tang-on-functional-dyspepsia-classified-as-excess-pattern-study-protocol-for-a-randomized-controlled-trial
#5
Yun Hee Kim, Jun Young Kim, So Young Jung, O-Jin Kwon, Jun-Hwan Lee, Chang-Gue Son
BACKGROUND: Functional dyspepsia (FD) refers to the presence of one or more gastrointestinal symptoms including postprandial fullness, epigastric pain, burning, and early satiety without an organic explanation for chronic symptoms. FD causes considerable discomfort in patients and affects their everyday activity and productivity. Because most conventional treatments have limited efficacy, numerous patients seek alternatives such as herbal medicines. In this proposed study, we will conduct a clinical trial of an herbal drug, Banha-sasim-tang (BST)...
November 9, 2017: Trials
https://www.readbyqxmd.com/read/29106746/low-dose-lithium-regimen-enhances-endochondral-fracture-healing-in-osteoporotic-rodent-bone
#6
Kathak Vachhani, Cari Whyne, Yufa Wang, David Burns, Diane Nam
Osteoporotic bone fractures are highly prevalent and involve lengthy recovery. Lithium, commonly used in psychiatric medicine, inhibits glycogen synthase kinase-3β in the Wnt/β-catenin pathway, leading to up-regulation of osteogenesis. Our recent preclinical work demonstrated that a 20mg/kg lithium dose administered beginning 7 days post-fracture for 14 days optimally improved femoral fracture healing in healthy rats at 4 weeks post fracture (46% higher torsional strength). In this study, lithium treatment was evaluated for healing of osteoporotic bone fractures...
November 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29102883/acute-respiratory-symptoms-associated-with-short-term-fluctuations-in-ambient-pollutants-among-schoolchildren-in-durban-south-africa
#7
Graciela Mentz, Thomas G Robins, Stuart Batterman, Rajen N Naidoo
Ambient air pollution has been associated with adverse respiratory outcomes, especially among children with asthma. This study reports on associations between daily ambient air pollutant concentrations and the respiratory symptoms of schoolchildren living in Durban, South Africa. This city is Africa's busiest port and a key hub for imported crude oil and exported refined petroleum and petrochemical products, and it experiences a mixture of air pollutants that reflects emissions from industry, traffic and biomass burning...
November 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29089204/the-impact-of-operative-time-and-hypothermia-in-acute-burn-surgery
#8
N Ziolkowski, A D Rogers, W Xiong, B Hong, S Patel, B Trull, M G Jeschke
BACKGROUND: Prolonged operative time and intraoperative hypothermia are known to have deleterious effects on surgical outcomes. Although millions of burn injuries undergo operative treatment globally every year, there remains a paucity of evidence to guide perioperative practice in burn surgery. This study evaluated associations between hypothermia and operative time on post-operative complications in acute burn surgery. METHOD: A historical cohort study from January 1, 2006 to October 31, 2015 was completed at an American Burn Association verified burn centre...
October 28, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29080911/impact-of-pain-and-postoperative-complications-on-patient-reported-outcome-measures-5%C3%A2-years-after-microvascular-decompression-or-partial-sensory-rhizotomy-for-trigeminal-neuralgia
#9
Daniyal J Jafree, Amanda C Williams, Joanna M Zakrzewska
BACKGROUND: Microvascular decompression (MVD) and partial sensory rhizotomy (PSR) provide longstanding pain relief in trigeminal neuralgia (TN). Given their invasiveness, complications can result from such posterior fossa procedures, but the impact of these procedures and their complications on patient-reported outcome measures (PROM), such as quality of life and distress, are not well established. METHOD: Five years after surgery, patients who underwent first MVD or PSR for TN at one institution, between 1982 and 2002, were sent a self-completion assessment set containing a range of PROMs: the Short Form-12 (SF-12) questionnaire to assess quality of life, the Hospital Anxiety and Depression Scale (HADS) to assess distress, and a questionnaire containing questions about postoperative complications, their severity and impact on quality of life...
October 28, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29078875/validity-of-the-braden-scale-in-grading-pressure-ulcers-in-trauma-and-burn-patients
#10
Lauren H Griswold, Russell L Griffin, Thomas Swain, Jeffrey D Kerby
BACKGROUND: Pressure ulcers are a costly hospital-acquired condition in terms of clinical outcome and expense. The Braden Scale was developed in 1987 as a risk scoring method for pressure ulcers and uses six different risk factors: sensory perception, moisture, activity, mobility, nutrition, and friction and shear. A score of ≤18 is considered high risk. To date, research on the utility of the Braden Scale has focused on general medicine and nontrauma/burn surgery patients. We hypothesize that the Braden Scale does not accurately discriminate who will get a pressure ulcer among trauma and burn patients...
November 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29066163/safety-and-efficacy-of-eculizumab-in-anti-acetylcholine-receptor-antibody-positive-refractory-generalised-myasthenia-gravis-regain-a-phase-3-randomised-double-blind-placebo-controlled-multicentre-study
#11
James F Howard, Kimiaki Utsugisawa, Michael Benatar, Hiroyuki Murai, Richard J Barohn, Isabel Illa, Saiju Jacob, John Vissing, Ted M Burns, John T Kissel, Srikanth Muppidi, Richard J Nowak, Fanny O'Brien, Jing-Jing Wang, Renato Mantegazza
BACKGROUND: Complement is likely to have a role in refractory generalised myasthenia gravis, but no approved therapies specifically target this system. Results from a phase 2 study suggested that eculizumab, a terminal complement inhibitor, produced clinically meaningful improvements in patients with anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis. We further assessed the efficacy and safety of eculizumab in this patient population in a phase 3 trial...
October 20, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29058641/a-systematic-review-protocol-on-the-effectiveness-of-therapeutic-exercises-utilised-by-physiotherapists-to-improve-function-in-patients-with-burns
#12
Tapfuma Mudawarima, Matthew Chiwaridzo, Jennifer Jelsma, Karen Grimmer, Faith Chengetayi Muchemwa
BACKGROUND: Therapeutic exercises play a crucial role in the management of burn injuries. The broad objective of this review is to systematically evaluate the effectiveness, safety and applicability to low-income countries of therapeutic exercises utilised by physiotherapists to improve function in patients with burns. Population = adults and children/adolescents with burns of any aspect of their bodies. Interventions = any aerobic and/or strength exercises delivered as part of a rehabilitation programme by anyone (e...
October 23, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29056125/quantification-and-further-refinements-of-dorsal-metacarpal-artery-perforator-flap-for-reconstruction-of-wounds-of-fingers-upto-distal-interphalangeal-joints
#13
Muhammad Amin Yousaf, Zain Ul Abidin, Farrukh Aslam Khalid, Kamran Khalid, Muhammad Saleem, Muhammad Jibran Rabbani, Abdul Malik Mujahid, Moazzam Nazeer Tarrar
OBJECTIVE: To assess the outcome of dorsal metacarpal artery perforator flap for coverage of finger defects extending upto distal interphalangeal joint (DIPJ). STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from March 2015 to May 2017. METHODOLOGY: Our study was carried out in two parts. 1st part of study was to measure average flap length in our population...
October 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29048468/policy-determinants-of-physical-activity-across-the-life-course-a-dedipac-umbrella-systematic-literature-review
#14
Anna Puggina, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Simon Chantal, Donatella Ciarapica, Giancarlo Condello, Tara Coppinger, Cristina Cortis, Sara D'Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Aileen Kennedy, Fiona Chun Man Ling, Agnes Luzak, Giorgio Napolitano, Julie-Anne Nazare, Camille Perchoux, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Rhoda Sohun, Astrid Steinbrecher, Wolfgang Schlicht, Walter Ricciardi, Ciaran MacDonncha, Laura Capranica, Stefania Boccia
Background: Despite the large number of studies and reviews available, the evidence regarding the policy determinants of physical activity (PA) is inconclusive. This umbrella systematic literature review (SLR) summarizes the current evidence on the policy determinants of PA across the life course, by pooling the results of the available SLRs and meta-analyses (MAs). Methods: A systematic online search was conducted on MEDLINE, ISI Web of Science, Scopus and SPORTDiscus databases up to April 2016...
October 18, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29032975/comparison-of-non-surgical-methods-for-the-treatment-of-deep-partial-thickness-skin-burns-of-the-hand
#15
Ernest Zacharevskij, Gytis Baranauskas, Karolis Varkalys, Rytis Rimdeika, Darius Kubilius
This paper describes a randomized, controlled, parallel-group, single-center clinical trial designed to compare non surgical treatment methods of deep partial thickness skin burns of the hand. All patients were scanned with the Laser Doppler Imaging device to determine the depth of the burn wound. Viable keratinocytes sites were determined according to the established Perfusion Units (PU) measurement system. The trial enrolled 87 patients with hand burn wounds in the section of 260-600PU. Hand burn patients were divided into the following four groups: treated with hydrocolloid dressings; treated with mechanical debridement of monofilament polyester fibers pad and then applying silver sulfadiazine; treated with gauze dressings containing enzymatic collagenase preparation...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29032972/long-term-cardiovascular-impacts-after-burn-and-non-burn-trauma-a-comparative-population-based-study
#16
Janine M Duke, Sean M Randall, Mark W Fear, Emily O'Halloran, James H Boyd, Suzanne Rea, Fiona M Wood
OBJECTIVE: To compare post-injury cardiovascular disease (CVD) hospital admissions experienced by burn patients with non-burn trauma patients and people with no record of injury, adjusting for socio-demographic, health and injury factors. METHODS: Linked hospital and death data were analysed for a cohort of burn patients (n=30,997) hospitalised in Western Australia during the period 1980-2012 and age and gender frequency matched comparison cohorts (non-burn trauma: n=28,647; non-injured: n=123,399)...
October 9, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29031889/outcomes-important-to-burns-patients-during-scar-management-and-how-they-compare-to-the-concepts-captured-in-burn-specific-patient-reported-outcome-measures
#17
Laura L Jones, Melanie Calvert, Naiem Moiemen, Jonathan J Deeks, Jonathan Bishop, Philip Kinghorn, Jonathan Mathers
BACKGROUND: Pressure garment therapy (PGT) is an established treatment for the prevention and treatment of hypertrophic scarring; however, there is limited evidence for its effectiveness. Burn survivors often experience multiple issues many of which are not adequately captured in current PGT trial measures. To assess the effectiveness of PGT it is important to understand what outcomes matter to patients and to consider whether patient-reported outcome measures (PROMs) can be used to ascertain the effect of treatments on patients' health-related quality of life...
October 11, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29021730/case-report-of-a-high-voltage-electrical-injury-and-review-of-the-indications-for-early-fasciotomy-in-limb-salvage-of-an-electrically-injured-limb
#18
T J Huei, S J Mohd Yussof, H T C Lip, I Salina
Electrical injuries make up a relatively small portion of burn injuries. Safety measures in place on domestic electricity supply have reduced the occurrence of high voltage electrical injuries. We present the case of a young man who sustained a high voltage electrical injury on all four limbs. Early fasciotomy was performed on both his hands and forearms. Despite early compartment release, the left upper limb deteriorated and required amputation. In this article we discuss the indications, outcomes and complications of early fasciotomy...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29021726/investigating-the-relationship-between-microalbuminuria-and-prognosis-of-patients-with-severe-burns-in-the-motahari-burn-hospital
#19
M Roham, K Anbari, M J Fatemi, M Momeni
Microalbuminuria seems to be a reflection of increased vascular permeability caused by systemic inflammatory response, and is likely to be a predictor of mortality, sepsis and other outcomes of severe burn patients. We investigated the impact of microalbuminuria on the prognosis of patients with severe burns. This is a prospective study on severe burn patients (above 20%) admitted in the first 24 hours after burns to the Motahari Burn Hospital. Patients' microalbuminuria was measured at admission and 48 hours later, and its relationship with patient prognosis (sepsis, renal failure, death, inhalation injury and systemic inflammatory response syndrome) was analyzed...
June 30, 2017: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/29021718/epidemiology-and-outcome-of-2-590-burned-patients-in-northwest-iran
#20
S N Hosseini, V Rashtchi, K Kamali, M H Moghimi
Burns are calamities with considerable morbidity and mortality rates. We attempted to examine the epidemiology of burns in Zanjan city, in northwest Iran, by a systematic study of existing information. The medical files of 2,590 thermal burn patients treated in our hospital in Zanjan city, Iran, from December 2010 to November 2016 were studied. Patient information, including age, sex, burn degree, season, cause of burn, hospital stay and treatment results were analyzed. About 65% of the patients were male (n=1691)...
June 30, 2017: Annals of Burns and Fire Disasters
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