Julie C Reid, Alex Molloy, Geoff Strong, Laurel Kelly, Heather O'Grady, Deborah Cook, Patrick M Archambault, Ian Ball, Sue Berney, Karen E A Burns, Frederick D'Aragon, Erick Duan, Shane W English, François Lamontagne, Amy M Pastva, Bram Rochwerg, Andrew J E Seely, Karim Serri, Jennifer L Y Tsang, Avelino C Verceles, Brenda Reeve, Alison Fox-Robichaud, John Muscedere, Margaret Herridge, Lehana Thabane, Michelle E Kho
RATIONALE: The COVID-19 pandemic disrupted non-COVID critical care trials globally as intensive care units (ICUs) prioritized patient care and COVID-specific research. The international randomized controlled trial CYCLE (Critical Care Cycling to Improve Lower Extremity Strength) was forced to halt recruitment at all sites in March 2020, creating immediate challenges. We applied the CONSERVE (CONSORT and SPIRIT Extension for RCTs Revised in Extenuating Circumstance) statement as a framework to report the impact of the pandemic on CYCLE and describe our mitigation approaches...
September 2, 2022: Trials