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https://www.readbyqxmd.com/read/28640917/human-hantavirus-infection-elicits-pronounced-redistribution-of-mononuclear-phagocytes-in-peripheral-blood-and-airways
#1
Saskia Scholz, Faezzah Baharom, Gregory Rankin, Kimia T Maleki, Shawon Gupta, Sindhu Vangeti, Jamshid Pourazar, Andrea Discacciati, Jonas Höijer, Matteo Bottai, Niklas K Björkström, Johan Rasmuson, Magnus Evander, Anders Blomberg, Hans-Gustaf Ljunggren, Jonas Klingström, Clas Ahlm, Anna Smed-Sörensen
Hantaviruses infect humans via inhalation of virus-contaminated rodent excreta. Infection can cause severe disease with up to 40% mortality depending on the viral strain. The virus primarily targets the vascular endothelium without direct cytopathic effects. Instead, exaggerated immune responses may inadvertently contribute to disease development. Mononuclear phagocytes (MNPs), including monocytes and dendritic cells (DCs), orchestrate the adaptive immune responses. Since hantaviruses are transmitted via inhalation, studying immunological events in the airways is of importance to understand the processes leading to immunopathogenesis...
June 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28637308/three-dimensional-right-ventricular-regional-deformation-and-survival-in-pulmonary-hypertension
#2
Pamela Moceri, Nicolas Duchateau, Delphine Baudouy, Elie-Dan Schouver, Sylvie Leroy, Fabien Squara, Emile Ferrari, Maxime Sermesant
Aims: Survival in pulmonary hypertension (PH) relates to right ventricular (RV) function. However, the RV unique anatomy and structure limit 2D analysis and its regional 3D function has not been studied yet. The aim of this study was to assess the implications of global and regional 3D RV deformation on clinical condition and survival in adults with PH and healthy controls. Methods and results: We collected a prospective longitudinal cohort of 104 consecutive PH patients and 34 healthy controls between September 2014 and December 2015...
June 15, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28637305/left-atrial-structure-and-function-in-cardiac-amyloidosis
#3
Kotaro Nochioka, Candida Cristina Quarta, Brian Claggett, Gabriela Querejeta Roca, Claudio Rapezzi, Rodney H Falk, Scott D Solomon
Aims: Although cardiac amyloidosis (CA) is characterized by significant left atrial (LA) dilatation, the characteristics of LA function remain to be fully investigated. Methods and results: We assessed LA function by speckle-tracking echocardiography in 124 patients with CA and sinus rhythm: 68 with light chain (AL), 29 with mutant (ATTRm), 27 with wild-type (ATTRwt) transthyretin amyloidosis. Conventional and strain-derived parameters, including LA peak longitudinal strain (LS) and strain rate (peak LSR: reservoir function; early LSR: conduit function; late LSR: active function), were assessed compared between CA patients and 20 healthy controls of similar age and gender...
June 16, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28637227/echocardiographic-reference-ranges-for-normal-left-ventricular-2d-strain-results-from-the-eacvi-norre-study
#4
Tadafumi Sugimoto, Raluca Dulgheru, Anne Bernard, Federica Ilardi, Laura Contu, Karima Addetia, Luis Caballero, Natela Akhaladze, George D Athanassopoulos, Daniele Barone, Monica Baroni, Nuno Cardim, Andreas Hagendorff, Krasimira Hristova, Teresa Lopez, Gonzalo de la Morena, Bogdan A Popescu, Marie Moonen, Martin Penicka, Tolga Ozyigit, Jose David Rodrigo Carbonero, Nico van de Veire, Ralph Stephan von Bardeleben, Dragos Vinereanu, Jose Luis Zamorano, Yun Yun Go, Monica Rosca, Andrea Calin, Julien Magne, Bernard Cosyns, Stella Marchetta, Erwan Donal, Gilbert Habib, Maurizio Galderisi, Luigi P Badano, Roberto M Lang, Patrizio Lancellotti
Aims: To obtain the normal ranges for 2D echocardiographic (2DE) measurements of left ventricular (LV) strain from a large group of healthy volunteers accounting for age and gender. Methods and results: A total of 549 (mean age: 45.6 ± 13.3 years) healthy subjects were enrolled at 22 collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. 2DE data sets have been analysed with a vendor-independent software package allowing homogeneous measurements irrespective of the echocardiographic equipment used to acquire the data sets...
June 16, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28636724/temporal-relationships-between-job-strain-and-low-back-pain
#5
Linda L Magnusson Hanson, Ida Eh Madsen, Reiner Rugulies, Paraskevi Peristera, Hugo Westerlund, Alexis Descatha
Objectives Psychosocial working conditions are suggested risk factors for low-back pain, but it is unclear whether these associations are causal. The present study examined whether there are lagged and bidirectional associations between job strain and low-back pain and further controlled for unmeasured time-invariant confounding. Methods The study was based on four biennial waves of data from the Swedish Longitudinal Occupational Survey of Health (SLOSH), including 3084 men and women. Cross-lagged analyses using structural equation modeling (SEM) were conducted on job strain, a combination of high job demands and low control, and any as well as low-back pain severity (how much any problems affected the respondents life)...
June 21, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28636515/a-brief-period-of-intensive-cardiac-rehabilitation-improves-global-longitudinal-strain-and-diastolic-function-after-a-first-uncomplicated-myocardial-infarction
#6
Gabriella Malfatto, Miriam Revera, Giovanna Branzi, Francesca Ciambellotti, Alessia Giglio, Simonetta Blengino, Matteo Oldani, Camilla Facchini, Gianfranco Parati, Mario Facchini
Objectives In patients with abnormal left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI), cardiac rehabilitation with physical training prevents cardiac remodelling. To define the role of rehabilitation in the recovery of ventricular function in less severe cases, we studied its effects on more refined indexes of left ventricular function in uncomplicated, low-risk patients. Methods and results Fifty-five patients underwent percutaneous coronary revascularization after uncomplicated first AMI...
March 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28634695/assessment-of-early-diastolic-intraventricular-pressure-gradient-in-the-left-ventricle-among-patients-with-repaired-tetralogy-of-fallot
#7
Maki Kobayashi, Ken Takahashi, Mariko Yamada, Kana Yazaki, Kotoko Matsui, Noboru Tanaka, Sachie Shigemitsu, Katsumi Akimoto, Masahiko Kishiro, Keisuke Nakanishi, Shiori Kawasaki, Masaki Nii, Keiichi Itatani, Toshiaki Shimizu
Assessment of left ventricular (LV) dysfunction is vital in patients with repaired tetralogy of Fallot (rTOF). The early diastolic intraventricular pressure gradient (IVPG) in the LV plays an important role in diastolic function. IVPG is calculated as the intraventricular pressure difference divided by the LV length, which allows to account for differences in LV size and therefore calculate IVPG in children. We aimed to investigate the mechanisms of LV diastolic dysfunction by measuring mid-to-apical IVPG as an indicator of the active suction force sucking blood from the left atrium into the LV...
June 20, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28631361/optimal-right-heart-filling-pressure-in-acute-respiratory-distress-syndrome-determined-by-strain-echocardiography
#8
Romel Garcia-Montilla, Faryal Imam, Mi Miao, Kathryn Stinson, Akram Khan, Stephen Heitner
INTRODUCTION: Right ventricular (RV) systolic dysfunction is common in acute respiratory distress syndrome (ARDS). While preload optimization is crucial in its management, dynamic fluid responsiveness indices lack reliability, and there is no consensus on target central venous pressure (CVP). We analyzed the utility of RV free wall longitudinal strain (RVFWS) in the estimation of optimal RV filling pressure in ARDS. METHODS: A retrospective cross-sectional analysis of clinical data and echocardiograms of patients with ARDS was performed...
June 2017: Echocardiography
https://www.readbyqxmd.com/read/28630445/myocardial-deformation-in-cardiac-amyloid-light-chain-amyloidosis-assessed-with-3t-cardiovascular-magnetic-resonance-feature-tracking
#9
Rui Li, Zhi-Gang Yang, Hua-Yan Xu, Ke Shi, Xi Liu, Kai-Yue Diao, Ying-Kun Guo
Clinically, assessment of myocardial function is essential in patients with amyloid light-chain cardiac amyloidosis (AL-CA) to predict outcome and determine therapeutic approach. The aim of this study was to investigate the feasibility of cardiovascular magnetic resonance (CMR)-derived feature tracking algorithm for assessing left ventricular (LV) myocardial deformation in AL-CA, and to determine if these abnormal myocardial deformation parameters are correlated to impaired LV myocardial microvascular dysfunction...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629386/strain-elastography-imaging-for-early-detection-and-prediction-of-tumor-response-to-concurrent-chemo-radiotherapy-in-locally-advanced-cervical-cancer-feasibility-study
#10
Yan Xu, Lijing Zhu, Baorui Liu, Tong Ru, Huanhuan Wang, Jian He, Song Liu, Xiaofeng Yang, Zhengyang Zhou, Tian Liu
BACKGROUND: To investigate the feasibility of strain elastography imaging in early detecting and predicting treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for locally advanced cervical cancer. METHODS: Between January 2015 and June 2016, 47 patients with locally advanced cervical cancer were enrolled in a feasibility study approved by the institutional review board. All patients underwent CCRT and received strain elastography examinations at 4 time points: pre-therapy (baseline), 1 week and 2 weeks during, as well as immediately post CCRT...
June 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28627046/donor-specific-antibodies-are-associated-with-micro-and-macrovascular-coronary-disease-restrictive-myocardial-damage-and-poor-outcome-in-heart-transplanted-patients
#11
Tor Skibsted Clemmensen, Pernille Koefoed-Nielsen, Lis-Ann Jensen, Steen Hvitfeldt Poulsen, Niels Ramsing Holm, Brian Bridal Løgstrup, Evald Høj Christiansen, Jouke Dijkstra, Kamilla Pernille Bjerre Valen, Hans Eiskjaer
AIMS: We examined the relationship between donor-specific HLA antibody (DSA) presence and graft function, hemodynamics, cardiac allograft vasculopathy (CAV), and major adverse cardiac events (MACE) in stable long-term heart-transplanted (HTx) patients. METHODS: Sera from 79 patients (median 7.5 years after HTx) were analyzed for DSA presence. Graft function was evaluated by echocardiography and right heart catheterization. CAV-burden was determined by coronary angiography, optical coherence tomography (OCT), and coronary flow velocity reserve (CFVR)...
June 19, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28625583/bridging-suture-makes-consistent-and-secure-fixation-in-double-row-rotator-cuff-repair
#12
Tetsutaro Fukuhara, Teruhisa Mihata, Bong Jae Jun, Masashi Neo
BACKGROUND: Inconsistent tension distribution may decrease the biomechanical properties of the rotator cuff tendon after double-row repair, resulting in repair failure. The purpose of this study was to compare the tension distribution along the repaired rotator cuff tendon among three double-row repair techniques. METHODS: In each of 42 fresh-frozen porcine shoulders, a simulated infraspinatus tendon tear was repaired by using 1 of 3 double-row techniques: (1) conventional double-row repair (no bridging suture); (2) transosseous-equivalent repair (bridging suture alone); and (3) compression double-row repair (which combined conventional double-row and bridging sutures)...
June 15, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28624411/incremental-prognostic-utility-of-left-ventricular-global-longitudinal-strain-in-asymptomatic-patients-with-significant-chronic-aortic-regurgitation-and-preserved-left-ventricular-ejection-fraction
#13
Alaa Alashi, Amgad Mentias, Amjad Abdallah, Ke Feng, A Marc Gillinov, L Leonardo Rodriguez, Douglas R Johnston, Lars G Svensson, Zoran B Popovic, Brian P Griffin, Milind Y Desai
OBJECTIVES: We sought to examine the prognostic utility of left ventricular (LV) global longitudinal strain (GLS) in asymptomatic patients with ≥III+ aortic regurgitation (AR), an indexed LV end-systolic dimension of <2.5 cm/m(2), and preserved left ventricular ejection fraction (LVEF). BACKGROUND: Management of asymptomatic patients with severe chronic AR and preserved LVEF is challenging and is typically based on LV dimensions. METHODS: We studied 1,063 such patients (53 ± 16 years; 77% men) seen between 2003 and 2010 (excluding those with symptoms, obstructive coronary artery disease, acute AR/dissection, aortic/mitral stenosis, more than moderate mitral regurgitation, and previous cardiac surgery)...
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28624406/global-longitudinal-strain-in-asymptomatic-chronic-aortic%C3%A2-regurgitation-the-missing-piece-for-the-watchful-waiting-puzzle
#14
EDITORIAL
João L Cavalcante
No abstract text is available yet for this article.
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28623910/pilot-study-using-3d-longitudinal-strain-computation-in-a-multi-parametric-approach-for-best-selecting-responders-to-cardiac-resynchronization-therapy
#15
Maxime Fournet, Anne Bernard, Sylvestre Marechaux, Elena Galli, Raphael Martins, Philippe Mabo, J Claude Daubert, Christophe Leclercq, Alfredo Hernandez, Erwan Donal
BACKGROUND: Almost all attempts to improve patient selection for cardiac resynchronization therapy (CRT) using echo-derived indices have failed so far. We sought to assess: the performance of homemade software for the automatic quantification of integral 3D regional longitudinal strain curves exploring left ventricular (LV) mechanics and the potential value of this tool to predict CRT response. METHODS: Forty-eight heart failure patients in sinus rhythm, referred for CRT-implantation (mean age: 65 years; LV-ejection fraction: 26%; QRS-duration: 160 milliseconds) were prospectively explored...
June 17, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28623061/comparison-of-extraosseous-talotarsal-stabilization-implants-in-a-stage-ii-adult-acquired-flatfoot-model-a-finite-element-analysis
#16
Jian Xu, Xin Ma, Daping Wang, Wei Lu, Weimin Zhu, Kan Ouyang, Haifeng Liu, Hao Li, Luoyong Jiang
Subtalar arthroereisis has been proved to be an efficient method for correcting flexible adult flatfoot. However, the optimal sinus tarsi implant is still debated and yet to be determined. In the present study, we compared the biomechanical effects of type I and II sinus tarsi implants in stage II adult-acquired flatfoot deformity (AAFD). First, a finite element model of stage II AAFD was established in which virtual surgery of subtalar arthroereisis was simulated. The indexes of plantar stress distribution, peak von Mises of the medial and lateral columns, strain of the medial ligaments and plantar fascia, arch height, talo-first metatarsal angle, calcaneus pitch angle, talonavicular coverage angle, and hindfoot valgus angle were all compared and analyzed...
June 13, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28620014/the-tendinopathic-achilles-tendon-does-not-remain-iso-volumetric-upon-repeated-loading-insights-from-3d-ultrasound
#17
Leila Nuri, Steven J Obst, Richard Newsham-West, Rod S Barrett
Mid-portion Achilles tendinopathy (MAT) alters the normal three-dimensional (3D) morphology of the Achilles tendon (AT) at rest and under a single tensile load. However, how MAT changes the 3D morphology of AT during repeated loading remains unclear. This study compared the AT longitudinal, transverse and volume strains during repeated loading in MAT with those of the contralateral tendon in people with unilateral MAT. Ten adults with unilateral MAT performed 10 successive 25 second submaximal (50%) voluntary isometric plantarflexion contractions with both legs...
June 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28617090/left-ventricular-function-in-relation-to-chronic-residential-air-pollution-in-a-general-population
#18
Wen-Yi Yang, Zhen-Yu Zhang, Lutgarde Thijs, Esmée M Bijnens, Bram G Janssen, Charlotte Vanpoucke, Wouter Lefebvre, Nicholas Cauwenberghs, Fang-Fei Wei, Aernout Luttun, Peter Verhamme, Etienne Van Hecke, Tatiana Kuznetsova, Jan D'hooge, Tim S Nawrot, Jan A Staessen
Background In view of the increasing heart failure epidemic and awareness of the adverse impact of environmental pollution on human health, we investigated the association of left ventricular structure and function with air pollutants in a general population. Methods In 671 randomly recruited Flemish (51.7% women; mean age, 50.4 years) we echocardiographically assessed left ventricular systolic strain and strain rate and the early and late peak velocities of transmitral blood flow and mitral annular movement (2005-2009)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28615148/echocardiographic-assessments-of%C3%A2-longitudinal-left-ventricular-function-in%C3%A2-healthy-english-springer-spaniels
#19
D Dickson, R Shave, M Rishniw, M Patteson
OBJECTIVES: To establish reference intervals for echocardiographic measures of longitudinal left ventricular function in adult English Springer spaniel (ESS) dogs. ANIMALS: This study involved 42 healthy adult ESS. METHODS: Animals were prospectively recruited from a general practice population in the United Kingdom. Dogs were examined twice, at least 12 months apart, to exclude dogs with progressive cardiac disease. Mitral annular plane systolic excursion, tissue Doppler imaging mitral annular velocities and two-dimensional speckle-tracking echocardiographic left ventricular longitudinal strain and strain rate were measured...
June 11, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28610963/the-influence-of-night-time-hypertension-on-left-ventricular-mechanics
#20
Marijana Tadic, Cesare Cuspidi, Biljana Pencic-Popovic, Vera Celic, Giuseppe Mancia
OBJECTIVE: The aim of this study was to evaluate left ventricular (LV) mechanics in individuals with daytime, night-time and day-nighttime hypertension. METHODS: This cross-sectional study included 272 untreated subjects who underwent 24-hour ambulatory blood pressure monitoring and complete two-dimensional echocardiographic examination including strain analysis. According to current guidelines, night-time hypertension was defined as nocturnal systolic blood pressure≥120mmHg and/or diastolic blood pressure≥70mmHg and day-time hypertension as systolic blood pressure≥135mmHg and/or diastolic blood pressure≥85mmHg...
June 6, 2017: International Journal of Cardiology
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