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https://www.readbyqxmd.com/read/28228654/low-ft3-a-possible-marker-of-frailty-in-the-elderly
#1
Aldo Bertoli, Alessia Valentini, Maria Assunta Cianfarani, Elena Gasbarra, Umberto Tarantino, Massimo Federici
INTRODUCTION: Frailty is associated with a functional decline of multiple physiological systems, of which they may be a cause or consequence. The objective of the study was to evaluate the prevalence of thyroid hormone modifications in elderly frail subjects and its relationship with frailty. STUDY POPULATION AND METHODS: An observational study was carried out at the University Hospital "Tor Vergata" in Rome among ambulatory and hospitalized patients. The study population consisted of 112 elderly subjects: 62 were hospitalized following hip fracture and 50 control subjects were outpatients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28223787/comparing-the-predictive-accuracy-of-frailty-comorbidity-and-disability-for-mortality-a-1-year-follow-up-in-patients-hospitalized-in-geriatric-wards
#2
Martin Ritt, Julia Isabel Ritt, Cornel Christian Sieber, Karl-Günter Gaßmann
BACKGROUND: Studies evaluating and comparing the power of frailty, comorbidity, and disability instruments, together and in parallel, for predicting mortality are limited. OBJECTIVE: This study aimed to evaluate and compare the measures of frailty, comorbidity, and disability in predicting 1-year mortality in geriatric inpatients. DESIGN: Prospective cohort study. PATIENTS AND SETTING: A total of 307 inpatients aged ≥65 years in geriatric wards of a general hospital participated in the study...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28177146/precarity-in-late-life-rethinking-dementia-as-a-frailed-old-age
#3
Amanda Grenier, Liz Lloyd, Chris Phillipson
Approaches to ageing that are organised around productivity, success, and active late life have contributed to views of dementia as an unsuccessful, failed or 'frailed' old age. Operating through dominant frameworks, socio-cultural constructs and organisational practices, the 'frailties' of the body and mind are often used to mark the boundaries of health and illness in late life, and shape responses accordingly. Our concern is that both the taken for granted and the 'imagined' can further marginalise persons who occupy the locations of dementia and disablement...
February 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28170120/physical-function-grip-strength-and-frailty-in-people-living-with-hiv-in-sub-saharan-africa-systematic-review
#4
REVIEW
Charlotte Bernard, François Dabis, Nathalie de Rekeneire
OBJECTIVE: To present the current knowledge on physical function, grip strength and frailty in HIV-infected patients living in sub-Saharan Africa, where the phenomenon is largely underestimated. METHODS: A systematic search was conducted on Medline, Scopus and African Index Medicus. We reviewed articles on sub-Saharan African people living with HIV (PLHIV) >18 years old, published until November 2016. RESULTS: Of 537 articles, 13 were conducted in six African countries and included in this review...
February 7, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28162927/the-standardization-of-frailty-phenotype-criteria-improves-its-predictive-ability-the-toledo-study-for-healthy-aging
#5
Cristina Alonso Bouzón, Jose Antonio Carnicero, Jimmy Gonzáles Turín, Francisco J García-García, Andrés Esteban, Leocadio Rodríguez-Mañas
INTRODUCTION: Several studies have assessed the performance of the original frailty phenotype criteria (FPC) and the standardized version according to the characteristics of the population. No studies exist, however, evaluating the impact of this standardization on its predictive ability. OBJECTIVE: To compare how the original FPC and the standardized-frailty phenotype criteria (S-FPC) estimate the prevalence of frailty and their ability to predict mortality, hospitalization, incident disability, and falls...
February 2, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28155181/nutrition-frailty-and-sarcopenia
#6
Alfonso J Cruz-Jentoft, Eva Kiesswetter, Michael Drey, Cornel C Sieber
Frailty and sarcopenia are important concepts in the quest to prevent physical dependence, as geriatrics are shifting towards identifications of early stages of disability. Definitions of both sarcopenia and frailty are still developing, and both concepts clearly overlap in their physical aspects. Malnutrition (both undernutrition and obesity) plays a key role in the pathogenesis of frailty and sarcopenia. The quality of the diet along the lifespan has a close relation with the incidence of both entities, and nutritional interventions may be able to reduce the incidence or revert either of them...
February 2, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28144914/the-sarcopenia-and-physical-frailty-in-older-people-multi-component-treatment-strategies-sprintt-randomized-controlled-trial-design-and-methods
#7
Francesco Landi, Matteo Cesari, Riccardo Calvani, Antonio Cherubini, Mauro Di Bari, Raphael Bejuit, Jerome Mshid, Sandrine Andrieu, Alan J Sinclair, Cornel C Sieber, Bruno Vellas, Eva Topinkova, Timo Strandberg, Leocadio Rodriguez-Manas, Fabrizia Lattanzio, Marco Pahor, Ronenn Roubenoff, Alfonso J Cruz-Jentoft, Roberto Bernabei, Emanuele Marzetti
The sustainability of health and social care systems is threatened by a growing population of older persons with heterogeneous needs related to multimorbidity, frailty, and increased risk of functional impairment. Since disability is difficult to reverse in old age and is extremely burdensome for individuals and society, novel strategies should be devised to preserve adequate levels of function and independence in late life. The development of mobility disability, an early event in the disablement process, precedes and predicts more severe forms of inability...
January 31, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28143618/the-psychometric-properties-of-the-chinese-version-reintegration-to-normal-living-index-c-rnli-for-identifying-participation-restriction-among-community-dwelling-frail-older-people
#8
Justina Yat-Wa Liu, Ka Wai Ma
BACKGROUND: The Reintegration to Normal Living Index (RNLI) was developed to measure reintegration to normal living after major traumas/illnesses. Its psychometric properties remain unknown when used to measure participation restriction under the World Health Organization's International Classification of Functioning, Disability, and Health (WHO-ICF) framework. This study examines the psychometric properties of the Chinese version-RNLI to measure WHO-ICF participation restriction among community-dwelling pre-frail and frail older people...
January 31, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28143597/the-severity-and-associated-factors-of-participation-restriction-among-community-dwelling-frail-older-people-an-application-of-the-international-classification-of-functioning-disability-and-health-who-icf
#9
Justina Yat Wa Liu
BACKGROUND: The International Classification of Functioning, Disability, and Health (WHO-ICF) describes participation restriction as one aspect of disability. Participation restriction refers to health problems that can hinder people's involvement in different life events. It is rational to believe that the prevalence of participation restriction increases among a frail population. However, information about the level of participation restriction among older people, particularly the pre-frail or frail, remains scant...
January 31, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28126138/general-practitioners-clinical-impression-in-the-screening-for-frailty-data-from-the-fap-study-pilot
#10
Bertrand Fougère, Marie-Josée Sirois, Pierre-Hugues Carmichael, Brice-Lionel Batomen-Kuimi, Bruno Chicoulaa, Emile Escourrou, Fati Nourhashémi, Stéphane Oustric, Bruno Vellas
BACKGROUND: The progression of frailty is marked by an increased risk of adverse health outcomes in the elderly including falls, physical and/or cognitive disability, hospitalizations, and mortality. In primary care, the general practitioner's (GP's) clinical impression about their elderly patients' frailty state seems to be a key point in identifying frail individuals in their clinical practice. The aim of this article is to examine if GPs' clinical impressions regarding frailty concurs with objective measures of the gold standard frailty phenotype as described by Fried in community-dwelling older persons...
February 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28126135/prevention-of-functional-decline-by-reframing-the-role-of-nursing-homes
#11
Clarisse Laffon de Mazières, John E Morley, Cari Levy, Fabien Agenes, Mario Barbagallo, Matteo Cesari, Philipe De Souto Barreto, Lorenzo Maria Donini, Jaime Fitten, Alain Franco, Mikel Izquierdo, Rosalie A Kane, Finbarr C Martin, Graziano Onder, Joseph Ouslander, Kaisu Pitkälä, Debra Saliba, Alan Sinclair, Leocadio Rodriguez Manas, Bruno Vellas, Yves Rolland
Institutionalization is generally a consequence of functional decline driven by physical limitations, cognitive impairments, and/or loss of social supports. At this stage, intervention to reverse functional losses is often too late. To be more effective, geriatric medicine must evolve to intervene at an earlier stage of the disability process. Could nursing homes (NHs) transform from settings in which many residents dwell to settings in which the NH residents and those living in neighboring communities benefit from staff expertise to enhance quality of life and maintain or slow functional decline? A task force of clinical researchers met in Toulouse on December 2, 2015, to address some of these challenges: how to prevent or slow functional decline and disabilities for NH residents and how NHs may promote the prevention of functional decline in community-dwelling frail elderly...
February 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28112495/design-of-the-mobility-and-independent-living-in-elders-study-an-older-adult-cohort-in-rural-india
#12
Tushar Singh, Pawan K Sharma, Guru Rajesh Jammy, Jane A Cauley, Clareann H Bunker, P S Reddy, Anne B Newman
AIM: The Mobility and Independent Living in Elders Study (MILES) was established in 2012 to estimate the prevalence, incidence, and risk factors for disability and age-related disease in rural older Indians. Here we describe the main goals of MILES, the essential elements of its design and examinations, and the initial findings from the baseline visit. METHODS: A random sample of 562 men and women aged ≥60 years was enrolled from the Medchal region in Telangana State...
January 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28089304/management-of-prostate-cancer-in-elderly-patients-recommendations-of-a-task-force-of-the-international-society-of-geriatric-oncology
#13
REVIEW
Jean-Pierre Droz, Gilles Albrand, Silke Gillessen, Simon Hughes, Nicolas Mottet, Stéphane Oudard, Heather Payne, Martine Puts, Gilbert Zulian, Lodovico Balducci, Matti Aapro
CONTEXT: Prostate cancer is the most frequent male cancer. Since the median age of diagnosis is 66 yr, many patients require both geriatric and urologic evaluation if treatment is to be tailored to individual circumstances including comorbidities and frailty. OBJECTIVE: To update the 2014 International Society of Geriatric Oncology (SIOG) guidelines on prostate cancer in men aged >70 yr. The update includes new material on health status evaluation and the treatment of localised, advanced, and castrate-resistant disease...
January 11, 2017: European Urology
https://www.readbyqxmd.com/read/28087677/incorporating-persistent-pain-in-phenotypic-frailty-measurement-and-prediction-of-adverse-health-outcomes
#14
Matthew C Lohman, Karen L Whiteman, Rebecca L Greenberg, Martha L Bruce
BACKGROUND: Frailty, a syndrome of physiological deficits, is prevalent among older adults and predicts elevated risk of adverse health outcomes. Although persistent pain predicts similar risk, it is seldom considered in frailty measurement. This article evaluated the construct and predictive validity of including persistent pain in phenotypic frailty measurement. METHODS: Frailty and persistent pain were operationalized using data from the Health and Retirement Study (2006-2012 waves)...
February 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28065454/the-prevalence-association-and-clinical-outcomes-of-frailty-in-maintenance-dialysis-patients
#15
So-Young Lee, Dong Ho Yang, Eunah Hwang, Seock Hui Kang, Sun-Hee Park, Tae Woo Kim, Duk Hyun Lee, Kisoo Park, Jun Chul Kim
OBJECTIVE: To investigate the clinical implications of frailty in chronic kidney disease patients undergoing maintenance hemodialysis and chronic peritoneal dialysis. DESIGN: In this prospective study, all of the participants completed the Short Form of the Kidney Disease Quality of Life questionnaire, Korean version, to determine their frailty phenotype. We also obtained blood chemistry and demographic data at enrollment. Data regarding the history of hospitalization and death were collected during the follow-up period...
March 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/28060439/factors-associated-with-unexpected-admissions-and-mortality-among-low-functioning-older-patients-receiving-home-medical-care
#16
Hiroyuki Umegaki, Atushi Asai, Shigeru Kanda, Keiko Maeda, Takuya Shimojima, Hideki Nomura, Masafumi Kuzuya
AIM: The need for and availability of home medical care for elderly patients with limitations in terms of access to medical facilities has been increasing. We investigated the association between low function, malnutrition, dementia and multicomorbidity with patient prognosis, focusing on unexpected hospital admissions and mortality in elderly non-cancer patients receiving home care. METHODS: The study included 124 Japanese patients receiving home medical care in the form of regular visits from doctors and nurses for physical and/or mental disability...
January 6, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28043934/sex-differences-in-frailty-a-systematic-review-and-meta-analysis
#17
REVIEW
E H Gordon, N M Peel, M Samanta, O Theou, S E Howlett, R E Hubbard
BACKGROUND: It is a well-described clinical phenomenon that females live longer than males, yet tend to experience greater levels of co-morbidity and disability. Females can therefore be considered both more frail (because they have poorer health status) and less frail (because they have a lower risk of mortality). This systematic review aimed to determine whether this ageing paradox is demonstrated when the Frailty Index (FI) is used to measure frailty. METHODS: Medline, EMBASE and CINAHL databases were searched for observational studies that measured FI and mortality in community-dwellers over 65years of age...
December 31, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/28039855/use-of-oral-anticoagulant-therapy-in-older-adults-with-atrial-fibrillation-after-acute-ischemic-stroke
#18
Emer R McGrath, Alan S Go, Yuchiao Chang, Leila H Borowsky, Margaret C Fang, Kristi Reynolds, Daniel E Singer
OBJECTIVES: To explore barriers to anticoagulation in older adults with atrial fibrillation (AF) at high risk of stroke and to identify opportunities for interventions that might increase use of oral anticoagulants (OACs). DESIGN: Retrospective cohort study. SETTING: Two large community-based AF cohorts. PARTICIPANTS: Individuals with ischemic stroke surviving hospitalization (N = 1,405, mean age 79). MEASUREMENTS: Using structured chart review, reasons for nonuse of OAC were identified, and 1-year poststroke survival was assessed...
February 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28039014/what-can-five-high-cost-patients-teach-us-about-healthcare-spending
#19
Ishani Ganguli, Ryan W Thompson, Timothy G Ferris
The highest cost patients account for a disproportionately large share of American healthcare costs and are increasingly the focus of research and policy efforts to stem the rapid growth of these costs. These patients tend to be medically complex and frail, but we know little about how such characteristics influence healthcare spending from the perspectives of the patients and their caregivers. Therefore, we examined five of the highest cost patients at an academic medical center in a case series. We interviewed the patients, their family members, and their clinicians and analyzed their claims data and medical charts to explore how patient and health system characteristics influenced their health costs...
December 27, 2016: Healthcare
https://www.readbyqxmd.com/read/28035938/dementia-and-pressure-ulcers-is-there-a%C3%A2-close-pathophysiological-interrelation
#20
Efraim Jaul, Oded Meiron
The current theoretical investigation aimed to explore common pathophysiological mechanisms underlying dementia and pressure ulcers (PU). Along with the increased longevity, especially in frail elderly patients, there is a higher rate of functional and cognitive impairment with dementia coinciding with disabilities, immobility resulting in a higher rate of PU. Understanding common etiological paths resulting in pressure ulcers and dementia is likely to produce new treatment strategies that could lead to the prevention of comorbid complications...
December 30, 2016: Journal of Alzheimer's Disease: JAD
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