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https://www.readbyqxmd.com/read/27855417/testosterone-deficiency-and-testosterone-treatment-in-older-men
#1
Farid Saad, Gabriele Röhrig, Stephan von Haehling, Abdulmaged Traish
Frailty is a clinical condition related to changes in metabolism, to sarcopenia, and to decline in muscle mass and strength, bone mineral density, and physical function with aging. The pathophysiology of frailty is multifactorial and associated with comorbidities. Testosterone is implicated in regulating metabolic functions, maintenance of muscle and bone, and inhibition of adipogenesis. In older individuals, reduced testosterone is thought to contribute to an altered state of metabolism, loss of muscle and bone, and increased fat, leading to sarcopenia, sarcopenic obesity, and frailty...
November 18, 2016: Gerontology
https://www.readbyqxmd.com/read/27842511/comparative-assessment-of-two-frailty-instruments-for-risk-stratification-in-elderly-surgical-patients-study-protocol-for-a-prospective-cohort-study
#2
Daniel I McIsaac, Monica Taljaard, Gregory L Bryson, Paul E Beaule, Sylvain Gagne, Gavin Hamilton, Emily Hladkowicz, Allen Huang, John Joanisse, Luke T Lavallée, Hussein Moloo, Kednapa Thavorn, Carl van Walraven, Homer Yang, Alan J Forster
BACKGROUND: Frailty is an aggregate expression of susceptibility to poor outcomes, owing to age-, and disease-related deficits that accumulate within multiple domains. Older patients who are frail before surgery are at an increased risk of morbidity and mortality, and use a disproportionately high amount of healthcare resources. While frailty is now a well-established risk factor for adverse postoperative outcomes, the perioperative literature lacks studies that: 1) compare the predictive accuracy of different frailty instruments; 2) consider the impact of frailty on patient-reported outcome measures; and 3) consider the acceptability and feasibility of using frailty instruments in clinical practice...
November 14, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27791218/fruit-and-vegetable-intake-and-physical-activity-as-predictors-of-disability-risk-factors-in-african-american-middle-aged-individuals
#3
S M L Ribeiro, J E Morley, T K Malmstrom, D K Miller
OBJECTIVE: To investigate fruit and vegetable intake (FVI) and different dimensions of physical activity (PA) as predictors of change in disabilities and other known precursors of progressive disability in a population-based sample of African Americans. DESIGN: Longitudinal investigation of the independent associations of reported FVI and PA with six-year changes in disabilities and other known precursors of progressive disability. SETTING: Longitudinal study of a population-representative cohort of late middle-aged African Americans...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27779573/individual-frailty-components-and-mortality-in-kidney-transplant-recipients
#4
Mara A McAdams-DeMarco, Hao Ying, Israel Olorundare, Elizabeth A King, Christine Haugen, Brian Buta, Alden L Gross, Rita Kalyani, Niraj M Desai, Nabil N Dagher, Bonnie E Lonze, Robert A Montgomery, Karen Bandeen-Roche, Jeremy D Walston, Dorry L Segev
BACKGROUND: Frailty increases early hospital readmission and mortality risk among kidney transplant (KT) recipients. While frailty represents a high-risk state for this population, the correlates of frailty, the patterns of the 5 frailty components, and the risk associated with these patterns are unclear. METHODS: 663 KT recipients were enrolled in a cohort study of frailty in transplantation (12/2008-8/2015). Frailty, ADL/IADL disability, CESD depression, education, and HRQOL were measured...
October 25, 2016: Transplantation
https://www.readbyqxmd.com/read/27754000/db-02-2-strict-control-of-hypertension-in-the-frail-elderly-is-it-beneficial-con
#5
Hiromi Rakugi
European guidelines (ESH-ESC2013) for the elderly have discussed well about treatment blood pressure (BP) levels and targeting BP levels. In general, elderly patients with systolic BP (SBP) ≥160 mmHg including individuals older than 80 years in good physical and mental conditions are recommended reducing SBP to between 150 and 140 mmHg. Furthermore, fit elderly patients <80 years old are recommended to consider antihypertensive treatment at SBP values ≥140 mmHg with a target SBP <140 mmHg. On the other hand, frail elderly patients are recommended to leave decisions on antihypertensive therapy to the treating physician, and based on monitoring of the clinical effects of treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27746669/the-value-of-a-gardening-service-for-the-frail-elderly-and-people-with-a-disability-living-in-the-community
#6
Anne Same, Elinda Ai Lim Lee, Beverley McNamara, Lorna Rosenwax
Little is known about the significance of gardening services for frail elderly people. This study explored the value of a gardening service for frail older people and people with a disability living in the community. Using qualitative and quantitative data collected from pre-gardening (n = 38) and post-gardening service delivery interviews (n = 35) and the Housing Enabler, the value of a gardening service was examined. Findings suggest that the service had a positive impact on the independence and emotional well-being of frail aged people and younger people with a functional disability, with little impact on physical health...
November 2016: Home Health Care Management & Practice
https://www.readbyqxmd.com/read/27742583/ability-of-self-reported-frailty-components-to-predict-incident-disability-falls-and-all-cause-mortality-results-from-a-population-based-study-of-older-british-men
#7
Efstathios Papachristou, S Goya Wannamethee, Lucy T Lennon, Olia Papacosta, Peter H Whincup, Steve Iliffe, Sheena E Ramsay
BACKGROUND: Frailty is a state of increased vulnerability to disability, falls, and mortality. The Fried frailty phenotype includes assessments of grip strength and gait speed, which are complex or require objective measurements and are challenging in routine primary care practice. In this study, we aimed to develop a simple assessment tool based on self-reported information on the 5 Fried frailty components to identify older people at risk of incident disability, falls, and mortality...
October 11, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27715322/effects-of-an-exercise-intervention-in-frail-older-patients-with-chronic-obstructive-pulmonary-disease-hospitalized-due-to-an-exacerbation-a-randomized-controlled-trial
#8
Irene Torres-Sánchez, Marie Carmen Valenza, Irene Cabrera-Martos, Isabel López-Torres, Ángela Benítez-Feliponi, Alicia Conde-Valero
The objective of this study was to determine whether an exercise intervention using a pedal exerciser is able to reduce disability in frail older patients with chronic obstructive pulmonary disease (COPD) during hospitalization due to an acute exacerbation. This study was a randomized, single-blind clinical trial. Fifty-eight frail older patients admitted to hospital due to an acute exacerbation of COPD (AECOPD) were included in this study. All patients received standard medical and pharmacological care. Patients assigned to the intervention group also received an exercise intervention...
August 11, 2016: COPD
https://www.readbyqxmd.com/read/27709237/visual-impairment-screening-at-the-geriatric-frailty-clinic-for-assessment-of-frailty-and-prevention-of-disability-at-the-g%C3%A3-rontop%C3%A3-le
#9
V Soler, S Sourdet, L Balardy, G Abellan van Kan, D Brechemier, M E Rougé-Bugat, N Tavassoli, M Cassagne, F Malecaze, F Nourhashémi, B Vellas
OBJECTIVES: To evaluate visual performance and factors associated with abnormal vision in patients screened for frailty at the Geriatric Frailty Clinic (GFC) for Assessment of Frailty and Prevention of Disability at Toulouse University Hospital. DESIGN: Retrospective, observational cross-sectional, single-centre study. SETTING: Institutional practice. PARTICIPANTS: Patients were screened for frailty during a single-day hospital stay between October 2011 and October 2014 (n = 1648)...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27709236/pre-frailty-frailty-and-multimorbidity-prevalences-and-associated-characteristics-from-two-french-national-surveys
#10
C Le Cossec, A-L Perrine, N Beltzer, C Fuhrman, L Carcaillon-Bentata
OBJECTIVE: To estimate the prevalence of pre-frailty, frailty and multimorbidity in individuals without disability in France. To describe independent determinants of each indicators. DESIGN: Two nationally representative cross-sectional French surveys. SETTINGS: Wave 2012 of the Health, Health Care and Insurance Survey (Enquête Santé et Protection Sociale, ESPS) and data from the Disability Healthcare Household section Survey (Enquête Handicap Santé - Ménages, HSM) from 2008...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27709235/frailty-diabetes-and-mortality-in-middle-aged-african-americans
#11
S Chode, T K Malmstrom, D K Miller, J E Morley
BACKGROUND: Older adult frail diabetics have high mortality risk, but data are limited regarding frail late middle-aged diabetics, especially for African-Americans. The aim of this study is to examine the association of diabetes with health outcomes and frailty in the African American Health (AAH) study. METHODS: AAH is a population-based longitudinal cohort study. Participants were African Americans (N=998) ages 49 to 65 years at baseline. Cross-sectional comparisons for diabetes included disability, function, physical performance, cytokines, and frailty...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27679995/new-atp8a2-gene-mutations-associated-with-a-novel-syndrome-encephalopathy-intellectual-disability-severe-hypotonia-chorea-and-optic-atrophy
#12
Elena Martín-Hernández, María Elena Rodríguez-García, Ana Camacho, Antoni Matilla-Dueñas, María Teresa García-Silva, Pilar Quijada-Fraile, Marc Corral-Juan, Pilar Tejada-Palacios, Rogelio Simón de Las Heras, Joaquín Arenas, Miguel A Martín, Francisco Martínez-Azorín
We report the clinical and biochemical findings from two unrelated patients who presented with a novel syndrome: encephalopathy, intellectual disability, severe hypotonia, chorea and optic atrophy. Whole exome sequencing (WES) uncovered a homozygous mutation in the ATP8A2 gene (NM_016529:c.1287G > T, p.K429N) in one patient and compound heterozygous mutations (c.1630G > C, p.A544P and c.1873C > T, p.R625W) in the other. Only one haploinsufficiency case and a family with a homozygous mutation in ATP8A2 gene (c...
October 2016: Neurogenetics
https://www.readbyqxmd.com/read/27670855/frailty-and-sarcopenia-in-elderly
#13
John E Morley
Frailty is a pre-disability syndrome where an older person can be identified as being at risk when exposed to stressors associated with high risk for disability or needing to be hospitalized. Two major frailty definitions exist. The physical phenotype of frailty and the multiple deficit model. A simple frailty screening tool-FRAIL-has been validated. Treatment of frailty involves resistance exercise, optimization of nutrition, and treatment of fatigue (sleep apnea, depression), treatable causes of weight loss and adjustment of polypharmacy...
September 26, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27650669/implementing-assessment-of-cognitive-function-and-frailty-into-primary-care-data-from-frailty-and-alzheimer-disease-prevention-into-primary-care-fap-study-pilot
#14
Bertrand Fougère, Stéphane Oustric, Julien Delrieu, Bruno Chicoulaa, Emile Escourrou, Yves Rolland, Fati Nourhashémi, Bruno Vellas
BACKGROUND: Aging can be affected by frailty and chronic diseases causing physical, cognitive, sensory, and functional decline evolving gradually to disability. The assessment of older patients is carried out in some geriatric day hospitals (GDHFs). However, it seems difficult to assess all patients in these GDHFs. In this context, a care model, which uses a specialist nurse trained in primary care and geriatric assessment, has been developed. In this article, we describe the organization, details of the evaluation, and provide the main characteristics of the first 200 patients assessed over a 6-month period...
September 16, 2016: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/27642911/db-02-2-strict-control-of-hypertension-in-the-frail-elderly-is-it-beneficial-con
#15
Hiromi Rakugi
European guidelines (ESH-ESC2013) for the elderly have discussed well about treatment blood pressure (BP) levels and targeting BP levels. In general, elderly patients with systolic BP (SBP) ≥160 mmHg including individuals older than 80 years in good physical and mental conditions are recommended reducing SBP to between 150 and 140 mmHg. Furthermore, fit elderly patients <80 years old are recommended to consider antihypertensive treatment at SBP values ≥140 mmHg with a target SBP <140 mmHg. On the other hand, frail elderly patients are recommended to leave decisions on antihypertensive therapy to the treating physician, and based on monitoring of the clinical effects of treatment...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27628103/significance-of-frailty-for-predicting-adverse-clinical-outcomes-in-different-patient-groups-with-specific-medical-conditions
#16
Martin Ritt, Karl-Günter Gaßmann, Cornel Christian Sieber
Frailty is a major health burden in an aging society. It constitutes a clinical state of reduced physiological reserves that is associated with a diminished ability to withstand internal and external stressors. Frail patients have an increased risk for adverse clinical outcomes, such as mortality, readmission to hospital, institutionalization and falls. Of further clinical interest, frailty might be at least in part reversible in some patients and subject to preventive strategies. In daily clinical practice older patients with a complex health status, who are mostly frail or at least at risk of developing frailty, are frequently cared for by geriatricians...
October 2016: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/27626795/effects-of-low-intensity-endurance-and-resistance-training-on-mobility-in-chronic-stroke-survivors-a-pilot-randomized-controlled-study
#17
Nicola Lamberti, Sofia Straudi, Anna M Malagoni, Matteo ARGIRò, Michele Felisatti, Eleonora Nardini, Christel Zambon, Nino Basaglia, Fabio Manfredini
BACKGROUND: Chronic stroke survivors are exposed to long-term disability and physical deconditioning, effects that may impact their independence and quality of life. Community-based programs optimizing the dose of exercise therapy that are simultaneously low risk and able to achieve high adherence should be identified. AIM: We tested the hypothesis that an 8-week, community-based, progressive mixed endurance- resistance exercise program at lower cardiovascular and muscular load yielded more mobility benefits than a higher-intensity program in chronic stroke survivors...
September 14, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27625579/using-prefrailty-to-detect-early-disability
#18
Miguel A Acosta-Benito, Ignacio Sevilla-Machuca
INTRODUCTION: In an aging population, new strategies are required to identify individuals at risk of adverse health outcomes. Frailty syndrome is related to negative health events. This increased risk may be used to identify individuals in which interventions can delay the onset of physical and functional complications. The aim of the study was to determine the relationship between the onset of frailty and the beginning of functional disability. MATERIALS AND METHODS: This was a cross-sectional observational study with consecutive sampling to analyze 146 patients aged seventy and older who come to the primary care center...
September 2016: Journal of Family & Community Medicine
https://www.readbyqxmd.com/read/27598703/animal-ownership-among-vulnerable-populations-in-regional-south-australia-implications-for-natural-disaster-preparedness-and-resilience
#19
Kirrilly Thompson, Joshua Trigg, Bradley Smith
CONTEXT: Few studies have examined the prevalence of animal ownership among populations likely to be at greater risk from disaster events within a bushfire context. OBJECTIVE: To investigate the proportion of vulnerable community members keeping animals and the types of animals kept, as well as perceived risk of harm to pets, and their inclusion in bushfire survival planning. DESIGN: Statewide anonymous online survey in 2014 of adult South Australian animal owners threatened by bushfire in January 2014...
January 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/27569712/frailty-and-sarcopenia-as-predictors-of-adverse-health-outcomes-in-persons-with-diabetes-mellitus
#20
Anthony Liccini, Theodore K Malmstrom
OBJECTIVES: Diabetes mellitus is associated with premature aging, and chronic diabetes is associated with significant physical and cognitive complications. We aimed to examine frailty and sarcopenia rates and 6-month health outcomes in a clinic-based sample of patients with diabetes. DESIGN: This study was an observational study. Participants were recruited from June 2014 to August 2014, and follow-up was conducted 6 months after day of screening. SETTING: Participants were recruited at outpatient endocrinology, geriatric, and internal medicine clinics affiliated with Saint Louis University in St...
September 1, 2016: Journal of the American Medical Directors Association
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