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disability, frail

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https://www.readbyqxmd.com/read/29907246/cognitive-impairment-and-the-association-between-frailty-and-functional-deficits-are-linked-to-abdominal-obesity-in-the-elderly
#1
Assaf Buch, Eli Carmeli, Gabi Shefer, Lital Keinan-Boker, Yitshal Berner, Yonit Marcus, Rebecca Goldsmith, Naftali Stern
OBJECTIVE: To evaluate whether specific obesity phenotypes in community-dwelling elderly: (a) affect differently the relationship between frailty and functional impairment and (b) are related to cognitive impairment. STUDY DESIGN: A post-hoc cross-sectional analysis of the last Israeli national health and nutrition survey of the elderly (≥ 65 yrs.; n = 1619). MAIN OUTCOME MEASURES: We implemented a previously validated frailty model based on frailty-related variables that were obtained in the survey...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29867301/what-is-the-duration-of-life-expectancy-in-the-state-of-frailty-estimates-in-the-sipaf-study
#2
Marie Herr, Jean-Jacques Arvieu, Joël Ankri, Jean-Marie Robine
The screening of frailty can trigger interventions aiming to delay disability in older people. Whereas the prevalence, the consequences, and the factors associated with frailty are well described, little is known about the duration of the state of frailty. This study aimed to estimate the time spent in the state of frailty in men and women using the Sullivan method. Data used were the age- and sex-specific prevalence of frailty found in SIPAF study ("Système d'Information sur la Perte d'Autonomie Fonctionnelle de la personne âgée") and statistics of mortality from the Human Mortality Database...
June 2018: European Journal of Ageing
https://www.readbyqxmd.com/read/29858193/frailty-in-critical-care-examining-implications-for-clinical-practices
#3
Jennifer A Gibson, Sarah Crowe
Frailty is an aging-related, multisystem clinical state characterized by loss of physiological reserves and diminished capacity to withstand exposure to stressors. Frailty increases the risk of serious adverse outcomes, compared with that of nonfrail people of the same age. Adverse outcomes can be severe and may include procedural complications, delirium, significant functional decline and disability, prolonged hospital length of stay, extended recovery periods, and death. As older adults make up a continually growing proportion of hospitalized patients, critical care nurses need to understand how to recognize frailty and be familiar with related clinical practice implications...
June 2018: Critical Care Nurse
https://www.readbyqxmd.com/read/29808951/frailty-phenotype-and-its-association-with-all-cause-mortality-in-community-dwelling-norwegian-women-and-men-aged-70-years-and-older-the-troms%C3%A3-study-2001-2016
#4
Petja Lyn Langholz, Bjørn Heine Strand, Sarah Cook, Laila A Hopstock
AIM: There is a lack of studies on the prevalence of frailty, and the association between frailty and mortality in a Norwegian general population. Findings regarding sex differences in the association between frailty and mortality have been inconsistent. The aim of the present study was to investigate the association between the frailty phenotype and all-cause mortality in men and women in a Norwegian cohort study. METHODS: We followed 712 participants (52% women) aged ≥70 years participating in the population-based Tromsø 5 Study in 2001-2002 for all-cause mortality up to 2016...
May 29, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29806856/interventions-against-disability-in-frail-older-adults-lessons-learned-from-clinical-trials
#5
B Fougère, J E Morley, M O Little, P De Souto Barreto, M Cesari, B Vellas
As the population ages, the number of older people with frailty is expected to increase worldwide with consequent rising of expenditures for healthcare and long-term care. Effective methods for preventing or delaying the onset of disability are urgently required. Frailty is a common and important geriatric condition characterized by age-associated declines in multiple physiological mechanisms, leading to increased vulnerability to stressors and higher risk for adverse health outcomes. Significant advancements have been made in the understanding of the frailty pathophysiological background...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29799055/approach-to-frailty-in-the-elderly-in-primary-care-and-the-community
#6
Christine Yuanxin Chen, Peiying Gan, Choon How How
Frailty is a distinct clinical syndrome wherein the individual has low reserves and is highly vulnerable to internal and external stressors. Although it is associated with disability and multiple comorbidities, it can also be present in individuals who seem healthy. Frailty is multidimensional and its pathophysiology is complex. Early identification and intervention can potentially decrease or reverse frailty, especially in the early stages. Primary care physicians, community nurses and community social networks have important roles in the identification of pre-frail and frail elderly through the use of simple frailty screening tools and rapid geriatric assessments...
May 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29796607/cardiovascular-risk-factors-and-frailty-in-a-cross-sectional-study-of-older-people-implications-for-prevention
#7
Tsz Yan Wong, M Sofia Massa, Aisling M O'Halloran, Rose Ann Kenny, Robert Clarke
Objective: to examine the associations of cardiovascular disease (CVD) and cardiovascular risk factors with frailty. Design: a cross-sectional study. Setting: the Irish Longitudinal Study on Ageing (TILDA). Participants: frailty measures were obtained on 5,618 participants and a subset of 4,330 participants with no prior history of CVD. Exposures for observational study: cardiovascular risk factors were combined in three composite CVD risk scores (Systematic Coronary Risk Evaluation [SCORE], Ideal Cardiovascular Health [ICH] and Cardiovascular Health Metrics [CHM])...
May 22, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29778652/frailty-and-diabetes-among-mexican-american-older-adults
#8
Bret T Howrey, Soham Al Snih, Kyriakos S Markides, Kenneth J Ottenbacher
PURPOSE: Progressive physical frailty in older adults is associated with increased risk of falls, disability, institutionalization, and mortality. Although associations between diabetes and frailty have been observed, the impact of diabetes on frailty in older Hispanics is largely unexplored. We examine the association of diabetes on the odds of frailty among older Mexican Americans. METHODS: Using data from the Hispanic Established Population for the Epidemiological Study of the Elderly from 1995 until 2012, frailty was assessed by slow gait, weak hand grip strength, exhaustion, and unexplained weight loss (n = 1327)...
July 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29765957/genetic-insights-into-frailty-association-of-9p21-23-locus-with-frailty
#9
Sanish Sathyan, Nir Barzilai, Gil Atzmon, Sofiya Milman, Emmeline Ayers, Joe Verghese
Frailty is a complex aging phenotype associated with increased vulnerability to disability and death. Understanding the biological antecedents of frailty may provide clues to healthy aging. The genome-wide association study hotspot, 9p21-23 region, is a risk locus for a number of age-related complex disorders associated with frailty. Hence, we conducted an association study to examine whether variations in 9p21-23 locus plays a role in the pathogenesis of frailty in 637 community-dwelling Ashkenazi Jewish adults aged 65 and older enrolled in the LonGenity study...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29741197/how-to-manage-frail-older-adults-in-the-community-proposal-of-a-health-promotion-program-experienced-in-a-city-of-16-638-inhabitants-in-france
#10
J de Kerimel, N Tavassoli, C Lafont, M Soto, M Pedra, F Nourhashemi, C Lagourdette, L Bouchon, A Chaléon, S Sourdet, Y Rolland, M Cesari, B Vellas
BACKGROUND: Health promotion programs could prevent and delay frailty and functional decline. However, in practice, the planning and establishment of such a program is a challenge for health care providers. We report an experimental model of screening and management for frail elderly conducted in Cugnaux, city of 16,638 inhabitants in France, by the Toulouse Gerontopole and the social care service of the Cugnaux City Hall. METHODS: A frailty screening self-administered questionnaire (FiND questionnaire) was sent to community-dwelling residents of 70 years old and over of Cugnaux...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29741193/identifying-exosome-derived-micrornas-as-candidate-biomarkers-of-frailty
#11
B R Ipson, M B Fletcher, S E Espinoza, A L Fisher
Frailty is a geriatric syndrome associated with progressive physical decline and significantly increases risk for falls, disability, hospitalizations, and death. However, much remains unknown regarding the biological mechanisms that contribute to aging and frailty, and to date, there are no clinically used prognostic or diagnostic molecular biomarkers. The present study profiled exosome-derived microRNAs isolated from the plasma of young, robust older, and frail older individuals and identified eight miRNAs that are uniquely enriched in frailty: miR-10a-3p, miR-92a-3p, miR-185-3p, miR-194-5p, miR-326, miR-532-5p, miR-576-5p, and miR-760...
2018: Journal of Frailty & Aging
https://www.readbyqxmd.com/read/29740921/hospitalization-and-morbidity-due-to-adverse-drug-reactions-in-elderly-patients-a-single-center-study
#12
Silvia Ognibene, Natale Vazzana, Claudio Giumelli, Luisa Savoldi, Luca Braglia, Giuseppe Chesi
BACKGROUND AND AIMS: Adverse drug reaction (ADRs) is a leading but underrecognized cause of illness particularly in frail subjects with multiple comorbidities. We aimed to investigate the frequency, patterns and outcomes of ADRs as a cause of hospitalization in elderly patients admitted to an internal medicine ward. METHODS: We performed a retrospective observational study including every patient aged over 65 years who was admitted to our Department during a 12-month period...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29731294/derivation-and-validation-of-a-predictive-model-for-the-readmission-of-patients-with-diabetes-mellitus-treated-in-internal-medicine-departments
#13
J Ena, R Gómez-Huelgas, B C Gracia-Tello, P Vázquez-Rodríguez, J N Alcalá-Pedrajas, F J Carrasco-Sánchez, B Murcia-Casas, M Romero-Sánchez, J V Segura-Heras, J Carretero
OBJECTIVES: We developed a predictive model for the hospital readmission of patients with diabetes. The objective was to identify the frail population that requires additional strategies to prevent readmissions at 90 days. METHODS: Using data collected from 1977 patients in 3 studies on the national prevalence of diabetes (2015-2017), we developed and validated a predictive model of readmission at 90 days for patients with diabetes. RESULTS: A total of 704 (36%) readmissions were recorded...
May 4, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29699732/vertebral-fragility-fractures-vff-who-when-and-how-to-operate
#14
Opinder Sahota, Terence Ong, Khalid Salem
Vertebral Fragility Fractures (VFF) are common and lead to pain, long term disability and increased mortality. Most patients will have mild to moderate pain symptoms and can be managed conservatively. However, patients with severe pain who have minimal or no pain relief with potent analgesia, or who only achieve adequate pain relief with high doses of morphine based analgesia which results in significant adverse events, should be considered for vertebral augmentation. Ideally, for vertebral augmentation, patients should present within four months of the fracture (onset of acute pain) and have at least 3 weeks of failure of conservative treatment although early intervention may be more appropriate for hospitalised patients, who tend to be older, more frail and likely to be less tolerant to the adverse effects of conservative treatment...
April 22, 2018: Injury
https://www.readbyqxmd.com/read/29669268/frailty-and-cognitive-status-evaluation-can-better-predict-mortality-in-older-adults
#15
Ivan Aprahamian, Claudia Kimie Suemoto, Márlon Juliano Romero Aliberti, Sileno de Queiroz Fortes Filho, Juliana de Araújo Melo, Sumika Mori Lin, Wilson Jacob Filho
OBJECTIVES: to evaluate the improvement in one-year mortality prediction after adding a 2-min cognitive screening to a simple 1-min frailty detection instrument. Secondary outcomes were new activities of daily living (ADL) disability and falls. DESIGN: Prospective cohort study. SETTING: A geriatric day-hospital for intermediate care. PARTICIPANTS: A total of 701 older adults with an acute or decompensated disease (79...
July 2018: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29648574/association-of-frailty-with-recovery-from-disability-among-community-dwelling-older-adults-results-from-two-large-u-s-cohorts
#16
Chenkai Wu, Dae H Kim, Qian-Li Xue, David S H Lee, Ravi Varadhan, Michelle C Odden
Background: Disability in activities of daily living (ADLs) is a dynamic process and transitions among different disability states are common. However, little is known about factors affecting recovery from disability. We examined the association between frailty and recovery from disability among non-disabled community-dwelling elders. Methods: We studied 1023 adults from the Cardiovascular Health Study (CHS) and 685 adults from the Health and Retirement Study (HRS), who were ≥65 years and had incident disability, defined as having difficulty in ≥1 ADL (dressing, eating, toileting, bathing, transferring, walking across a room)...
April 10, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29644805/role-of-autonomic-nervous-activity-as-measured-by-heart-rate-variability-on-the-effect-of-mortality-in-disabled-older-adults-with-low-blood-pressure-in-long-term-care
#17
Koji Shibasaki, Sumito Ogawa, Shizuru Yamada, Yasuyoshi Ouchi, Masahiro Akishita
AIM: Previous studies have shown the relationship between low blood pressure and high mortality in frail, disabled older adults in long-term care. However, the mechanism of this relationship is still unclear. We hypothesized that autonomic nervous activity decline is involved in the relationship between low blood pressure and high mortality. METHODS: The present prospective cohort study recruited 61 participants aged ≥75 years. The data from 24-h Holter monitoring and blood pressure recorded by ambulatory blood pressure monitoring were collected...
April 11, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29627160/tackling-socioeconomic-inequalities-and-non-communicable-diseases-in-low-income-and-middle-income-countries-under-the-sustainable-development-agenda
#18
REVIEW
Louis W Niessen, Diwakar Mohan, Jonathan K Akuoku, Andrew J Mirelman, Sayem Ahmed, Tracey P Koehlmoos, Antonio Trujillo, Jahangir Khan, David H Peters
Five Sustainable Development Goals (SDGs) set targets that relate to the reduction of health inequalities nationally and worldwide. These targets are poverty reduction, health and wellbeing for all, equitable education, gender equality, and reduction of inequalities within and between countries. The interaction between inequalities and health is complex: better economic and educational outcomes for households enhance health, low socioeconomic status leads to chronic ill health, and non-communicable diseases (NCDs) reduce income status of households...
May 19, 2018: Lancet
https://www.readbyqxmd.com/read/29626427/engineering-improved-balance-confidence-in-older-adults-with-complex-health-care-needs-learning-from-the-muscling-up-against-disability-study
#19
Sharon Hetherington, Tim Henwood, Paul Swinton, Justin Keogh, Paul Gardiner, Anthony Tuckett, Kevin Rouse
OBJECTIVE: To investigate the associations of balance confidence with physical and cognitive markers of well-being in older adults receiving government-funded aged care services and whether progressive resistance plus balance training could positively influence change. DESIGN: Intervention study. SETTING: Community-based older adult-specific exercise clinic. PARTICIPANTS: Older adults (N=245) with complex care needs who were receiving government-funded aged care support...
April 5, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29620558/effect-of-low-intensity-versus-high-intensity-resistance-training-on-the-functioning-of-the-institutionalized-frail-elderly
#20
Ulku K Sahin, Nuray Kirdi, Ergun Bozoglu, Aydin Meric, Galip Buyukturan, Ahmet Ozturk, Huseyin Doruk
Frailty has emerged as an important risk factor for disability. Age-related declines in physical and physiological function lead to increased risk of loss of independence and poor quality of life. Recent evidence has shown the effectiveness of physical exercise programmes in preventing or reversing frailty. The aim of this study was to evaluate changes in the functioning of frail elderly individuals after undergoing resistance training for 3 days a week for 8 weeks. The effectiveness of exercise training was investigated in 48 frail elderly individuals who were randomly assigned to the following intervention groups: high-intensity (HI; n=16; age: 69-96 years) or low-intensity (LI; n=16; age: 77-93 years) strength training groups or a control group (n=16; age: 76-93 years) with no specific exercise programme...
April 3, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
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