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https://www.readbyqxmd.com/read/28103294/community-based-entomological-surveillance-reveals-urban-foci-of-chagas-disease-vectors-in-sobral-state-of-cear%C3%A3-northeastern-brazil
#1
Cynara Carvalho Parente, Fernando S M Bezerra, Plutarco I Parente, Raimundo V Dias-Neto, Samanta C C Xavier, Alberto N Ramos, Filipe A Carvalho-Costa, Marli M Lima
BACKGROUND: The aim of this work was to explore the potential risk of vector-borne Chagas disease in urban districts in northeastern Brazil, by analyzing the spatiotemporal distributions and natural infection rates with Trypanosoma cruzi of triatomine species captured in recent years. The main motivation of this work was an acute human case of Chagas disease reported in 2008 in the municipality of Sobral. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed data from community-based entomological surveillance carried out from 2010 to 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28100932/defecography-by-digital-radiography-experience-in-clinical-practice
#2
Amanda Nogueira de Sá Gonçalves, Marco Aurélio Sousa Sala, Rodrigo Ciotola Bruno, José Alberto Cunha Xavier, João Mauricio Canavezi Indiani, Marcelo Fontalvo Martin, Paulo Maurício Chagas Bruno, Marcelo Souto Nacif
OBJECTIVE: The objective of this study was to profile patients who undergo defecography, by age and gender, as well as to describe the main imaging and diagnostic findings in this population. MATERIALS AND METHODS: This was a retrospective, descriptive study of 39 patients, conducted between January 2012 and February 2014. The patients were evaluated in terms of age, gender, and diagnosis. They were stratified by age, and continuous variables are expressed as mean ± standard deviation...
November 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/28100930/radiological-findings-in-megaesophagus-secondary-to-chagas-disease-chest-x-ray-and-esophagogram
#3
Thiago Giansante Abud, Lucas Giansante Abud, Vanessa Sales Vilar, Denis Szejnfeld, Samuel Reibscheid
OBJECTIVE: To identify and classify the radiographic patterns of megaesophagus in Chagas disease, as seen on esophagograms and chest X-rays. MATERIALS AND METHODS: This was a prospective study of 35 patients diagnosed with esophageal disease via manometry. The changes found on esophagograms were stratified according to Rezende's classification, divided into four categories (grades I through IV) determined by the degree of dilatation and impairement of esophageal motility...
November 2016: Radiologia Brasileira
https://www.readbyqxmd.com/read/28099588/dobutamine-stress-echocardiography-safety-in-chagas-disease-patients
#4
Daniela do Carmo Rassi, Marcelo Luiz Campos Vieira, Rogerio Gomes Furtado, Fabio de Paula Turco, Luciano Henrique Melato, Viviane Tiemi Hotta, Colandy Godoy de Oliveira Nunes, Luiz Rassi, Salvador Rassi
Background: A few decades ago, patients with Chagas disease were predominantly rural workers, with a low risk profile for obstructive coronary artery disease (CAD). As urbanization has increased, they became exposed to the same risk factors for CAD of uninfected individuals. Dobutamine stress echocardiography (DSE) has proven to be an important tool in CAD diagnosis. Despite being a potentially arrhythmogenic method, it is safe for coronary patients without Chagas disease. For Chagas disease patients, however, the indication of DSE in clinical practice is uncertain, because of the arrhythmogenic potential of that heart disease...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28099488/-i-cannot-be-worried-living-with-chagas-disease-in-tropical-bolivia
#5
Colin J Forsyth
BACKGROUND: Chagas disease (CD) profoundly affects the social and emotional dimensions of patients' lives, and disproportionately impacts poor, marginalized populations in Latin America. Biomedical treatment for CD fails to reach up to 99% of the people affected, and in any case seldom addresses the emotional health or socioeconomic conditions of patients. This study examines patient strategies for coping with CD in the department of Santa Cruz, Bolivia. METHODOLOGY: In this ethnographic study, semistructured interviews took place from March-June 2013 with 63 patients who had previously tested positive for CD...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28095511/epidemiology-and-molecular-typing-of-trypanosoma-cruzi-in-naturally-infected-hound-dogs-and-associated-triatomine-vectors-in-texas-usa
#6
Rachel Curtis-Robles, Karen F Snowden, Brandon Dominguez, Lewis Dinges, Sandy Rodgers, Glennon Mays, Sarah A Hamer
BACKGROUND: Trypanosoma cruzi is the etiologic agent of Chagas disease throughout the Americas. Few population-level studies have examined the epidemiology of canine infection and strain types of T. cruzi that infect canines in the USA. We conducted a cross-sectional study of T. cruzi infection in working hound dogs in south central Texas, including analysis of triatomine vectors collected within kennel environments. METHODOLOGY/PRINCIPLE FINDINGS: Paired IFA and Chagas Stat-Pak serological testing showed an overall seroprevalence of 57...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28095503/detection-of-a-potential-new-bartonella-species-candidatus-bartonella-rondoniensis-in-human-biting-kissing-bugs-reduviidae-triatominae
#7
Maureen Laroche, Jean-Michel Berenger, Oleg Mediannikov, Didier Raoult, Philippe Parola
BACKGROUND: Among the Reduviidae family, triatomines are giant blood-sucking bugs. They are well known in Central and South America where they transmit Trypanosoma cruzi to mammals, including humans, through their feces. This parasitic protozoan is the causative agent of Chagas disease, a major public health issue in endemic areas. Because of the medical and economic impact of Chagas disease, the presence of other arthropod-borne pathogens in triatomines was rarely investigated. METHODOLOGY/PRINCIPAL FINDINGS: In this study, seven triatomines species involved in the transmission of T...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28095298/molecular-identification-and-genotyping-of-trypanosoma-cruzi-dna-in-autochthonous-chagas-disease-patients-from-texas-usa
#8
Melissa N Garcia, Hadley Burroughs, Rodion Gorchakov, Sarah M Gunter, Eric Dumonteil, Kristy O Murray, Claudia P Herrera
The parasitic protozoan Trypanosoma cruzi, the causative agent of Chagas disease, is widely distributed throughout the Americas, from the southern United States (US) to northern Argentina, and infects at least 6 million people in endemic areas. Much remains unknown about the dynamics of T. cruzi transmission among mammals and triatomine vectors in sylvatic and peridomestic eco-epidemiological cycles, as well as of the risk of transmission to humans in the US. Identification of T. cruzi DTUs among locally-acquired cases is necessary for enhancing our diagnostic and clinical prognostic capacities, as well as to understand parasite transmission cycles...
January 14, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28093440/cross-sectional-descriptive-study-of-chagas-disease-among-citizens-of-bolivian-origin-living-in-munich-germany
#9
Miriam Navarro, Nicole Berens-Riha, Stefan Hohnerlein, Peter Seiringer, Charlotte von Saldern, Sarah Garcia, Teresa Blasco-Hernández, Bárbara Navaza, Jonathan Shock, Gisela Bretzel, Michael Hoelscher, Thomas Löscher, Pedro Albajar-Viñas, Michael Pritsch
PURPOSE: Chagas disease (CD) has become a global health issue mainly due to migration. Germany lacks surveillance data and is home to a large Latin American immigrant population. Recognising that Bolivia is the country with the highest CD prevalence in Latin America, this cross-sectional, descriptive pilot study investigated CD and associated factors among citizens of Bolivian origin living in Munich, Germany. METHODS: Participants completed a questionnaire in order to collect socioeconomic and health-related data...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28091763/the-prevalence-of-trypanosoma-cruzi-the-causal-agent-of-chagas-disease-in-texas-rodent-populations
#10
Adriana Aleman, Trina Guerra, Troy J Maikis, Matthew T Milholland, Ivan Castro-Arellano, Michael R J Forstner, Dittmar Hahn
Rodent species were assessed as potential hosts of Trypanosoma cruzi, the etiologic agent of Chagas disease, from five sites throughout Texas in sylvan and disturbed habitats. A total of 592 rodents were captured, resulting in a wide taxonomic representation of 11 genera and 15 species. Heart samples of 543 individuals were successfully analyzed by SybrGreen-based quantitative PCR (qPCR) targeting a 166 bp fragment of satellite DNA of T. cruzi. Eight rodents representing six species from six genera and two families were infected with T...
January 13, 2017: EcoHealth
https://www.readbyqxmd.com/read/28089650/neither-quantification-by-qpcr-nor-quantitative-elisa-can-be-used-to-discriminate-angus-cattle-for-resistance-susceptibility-to-babesia-bovis
#11
Rodrigo Giglioti, Henrique Nunes Oliveira, Adriana Mércia Guaratini Ibelli, Talita Barban Bilhassi, Thalita Athiê Néo, Clarissa Helena Santana, Márcio Dias Rabelo, Rosângela Zacarias Machado, Ana Carolina de Souza Chagas, Márcia Cristina de Sena Oliveira
With the aim of finding quantitative phenotypic traits that can be used to discriminate the levels of resistance/susceptibility to Babesia bovis, we estimated the repeatability and correlation between the level of infection, determined by the number of copies of a fragment of the gene that encodes cytochrome B (NC mt-cyB) of B. bovis, and the levels of the anti-B. bovis antibodies, in blood samples collected from 51 Angus cattle on two different occasions. Samples with the anticoagulant EDTA were used for DNA extraction and without anticoagulant for separation of the blood serum...
November 21, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28087471/il-6-promotes-m2-macrophage-polarization-by-modulating-purinergic-signaling-and-regulates-the-lethal-release-of-nitric-oxide-during-trypanosoma-cruzi-infection
#12
Liliana M Sanmarco, Nicolás E Ponce, Laura M Visconti, Natalia Eberhardt, Martin G Theumer, Ángel R Minguez, Maria P Aoki
The production of nitric oxide (NO) is a key defense mechanism against intracellular pathogens but it must be tightly controlled in order to avoid excessive detrimental oxidative stress. In this study we described a novel mechanism through which interleukin (IL)-6 mediates the regulation of NO release induced in response to Trypanosoma cruzi infection. Using a murine model of Chagas disease, we found that, in contrast to C57BL/6 wild type (WT) mice, IL-6-deficient (IL6KO) mice exhibited a dramatic increase in plasma NO levels concomitant with a significantly higher amount of circulating IL-1β and inflammatory monocytes...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28077696/a-new-development-in-trypanosoma-cruzi-diagnosis
#13
Herbert B Tanowitz, Louis M Weiss
Chagas disease caused by the parasite, Trypanosoma cruzi is an important cause of morbidity and mortality in endemic areas of Latin America and among infected individuals who have migrated to non-endemic areas of North America and Europe. There are many diagnostic tests that are employed in the serological diagnosis of this infection. In this issue of the J Clin Microbiol 55: XXX-XXX http://dx.doi:10.1128/JCM.01649-16 by Bautista-López et al provide characterization of excretory vesicles (EV) from Vero cells infected with T...
January 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28077331/physiological-behavioral-changes-induced-by-a-fraction-with-antitumor-cleronade-diterpenes-from-an-atlantic-forest-brazilian-plant-and-computational-intermolecular-interactions-with-neuron-receptors
#14
Éverton José Ferreira de Araújo, Antônia Amanda Cardoso de Almeida, Oskar Almeida Silva, Iwyson Henrique Fernandes da Costa, Luis Mário Rezende Júnior, Francisco das Chagas Alves Lima, Luciano da Silva Lopes, Alberto José Cavalheiro, Paulo Michel Pinheiro Ferreira
ETHNOPHARMACOLOGICAL RELEVANCE: Casearia sylvestris is a medicinal plant traditionally used to treat snakebites, wounds, inflammation and gastric ulcers and scientific supports for have demonstrated its antitumor, antihyperlipidemic and antiparasitic properties. AIM OF THE STUDY: To assess the effects of a fraction with casearins (FC) on adult mice using classical experimental models of animal behavior and theoretical calculations to verify the interaction of Casearin X (Cas X) with neuron receptors...
January 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28077180/understanding-transmissibility-patterns-of-chagas-disease-through-complex-vector-host-networks
#15
Laura Rengifo-Correa, Christopher R Stephens, Juan J Morrone, Juan Luis Téllez-Rendón, Constantino González-Salazar
Chagas disease is one of the most important vector-borne zoonotic diseases in Latin America. Control strategies could be improved if transmissibility patterns of its aetiologic agent, Trypanosoma cruzi, were better understood. To understand transmissibility patterns of Chagas disease in Mexico, we inferred potential vectors and hosts of T. cruzi from geographic distributions of nine species of Triatominae and 396 wild mammal species, respectively. The most probable vectors and hosts of T. cruzi were represented in a Complex Inference Network, from which we formulated a predictive model and several associated hypotheses about the ecological epidemiology of Chagas disease...
January 12, 2017: Parasitology
https://www.readbyqxmd.com/read/28076955/post-translational-modifications-of-trypanosoma-cruzi-canonical-and-variant-histones
#16
Gisele F A Picchi, Vanessa Zulkievicz, Marco Aurelio Krieger, Nilson T Zanchin, Samuel Goldenberg, Lyris M F de Godoy
Chagas disease, caused by Trypanosoma cruzi, still affects millions of people around the world. No vaccines neither treatment for chronic Chagas disease are available, and chemotherapy for the acute phase is hindered by limited efficacy and severe side effects. The processes by which the parasite acquires infectivity and survives in different hosts involve tight regulation of gene expression, mainly post-transcriptionally. Nevertheless, chromatin structure/organization of trypanosomatids is similar to other eukaryotes, including histone variants and post-translational modifications...
January 11, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28076583/-social-factors-associated-with-use-of-prenatal-care-in-ecuador
#17
Amaya Sánchez-Gómez, William Cevallos, Mario J Grijalva, Luis C Silva-Ayçaguer, Susana Tamayo, Jerry O Jacobson, Jaime A Costales, Rodrigo Jiménez-Garcia, Valentín Hernández-Barrera, Suzanne Serruya, Celia Riera
Objectives: Prenatal care is a pillar of public health, enabling access to interventions including prevention of mother-to-child transmission of HIV and congenital syphilis. This paper describes social factors related to use of prenatal care in Ecuador. Methods: In 2011 and 2012, participant clinical history and interview information was analyzed from a national probability sample of 5 998 women presenting for delivery or miscarriage services in 15 healthcare facilities in Ecuador, to estimate prevalence of HIV, syphilis, and Chagas disease, and prenatal care coverage...
November 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28071587/new-imidazole-based-compounds-active-against-trypanosoma-cruzi
#18
Oluyomi Stephen Adeyemi, Maria Teresa Molina, Abiodun Omokehinde Eseola, Cristina Fonseca-Berzal, Alicia Gomez-Barrio
Current drugs available for the treatment of Chagas disease are fraught with several challenges including severe toxicity and limited efficacy. These factors coupled with the absence of effective drugs for treating the chronic stage of the disease have rendered the development of new drugs against Chagas disease a priority. This study screened several imidazole-based compounds for anti-Trypanosoma potential. Using in vitro experimental infection model, several imidazole-based compounds were screened for anti-proliferative effect on Trypanosoma cruzi epimastigotes...
January 10, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28066534/chagas-disease-research-and-development-is-there-light-at-the-end-of-the-tunnel
#19
REVIEW
Eric Chatelain
Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration. Although it was first identified more than a century ago, only two old drugs are available for treatment and a lot of questions related to the disease progression, its pathologies, and not to mention the assessment of treatment efficacy, are subject to debate and remain to be answered. Indeed, the current status of evidence and data available does not allow any absolute statement related to treatment needs and outcome for Chagas patients to be made...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28062289/evaluation-of-p2x7-receptor-expression-in-peripheral-lymphocytes-and-immune-profile-from-patients-with-indeterminate-form-of-chagas-disease
#20
Viviane do Carmo Gonçalves Souza, Joabel Tonellotto Dos Santos, Fernanda Licker Cabral, Fernanda Barbisan, Maria Isabel Azevedo, Luiz Felipe Dias Carli, Sonia de Avila Botton, Jeandre Augusto Dos Santos Jaques, Daniela Bitencourt Rosa Leal
Chagas disease (CD) is caused by Trypanosoma cruzi, an intracellular protozoan which is a potent stimulator of cell-mediated immunity. In the indeterminate form of CD (IFCD) a modulation between pro- and anti-inflammatory responses establishes a host-parasite adaptation. It was previously demonstrated that purinergic ecto-enzymes regulates extracellular ATP and adenosine levels, influencing immune and inflammatory processes during IFCD. In inflammatory sites ATP, as well as its degradation product, adenosine, function as signaling molecules and immunoregulators through the activation of purinergic receptors...
January 3, 2017: Microbial Pathogenesis
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