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https://www.readbyqxmd.com/read/28719603/the-%C3%A2-100-lab-a-3d-printable-open-source-platform-for-fluorescence-microscopy-optogenetics-and-accurate-temperature-control-during-behaviour-of-zebrafish-drosophila-and-caenorhabditis-elegans
#1
Andre Maia Chagas, Lucia L Prieto-Godino, Aristides B Arrenberg, Tom Baden
Small, genetically tractable species such as larval zebrafish, Drosophila, or Caenorhabditis elegans have become key model organisms in modern neuroscience. In addition to their low maintenance costs and easy sharing of strains across labs, one key appeal is the possibility to monitor single or groups of animals in a behavioural arena while controlling the activity of select neurons using optogenetic or thermogenetic tools. However, the purchase of a commercial solution for these types of experiments, including an appropriate camera system as well as a controlled behavioural arena, can be costly...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28719275/high-triatoma-brasiliensis-densities-and-trypanosoma-cruzi-prevalence-in-domestic-and-peridomestic-habitats-in-the-state-of-rio-grande-do-norte-brazil-the-source-for-chagas-disease-outbreaks
#2
Mauricio Lilioso, Elaine Folly-Ramos, Fabiana Lopes Rocha, Jorge Rabinovich, Claire Capdevielle-Dulac, Myriam Harry, Paula L Marcet, Jane Costa, Carlos Eduardo Almeida
AbstractA total of 2,431 Triatoma brasiliensis were collected from 39 populations of Paraíba (PB) and Rio Grande do Norte (RN) states, Brazil. In PB, Trypanosoma cruzi infection was not detected in either peridomestic or domestic vector populations. In contrast, in RN, T. brasiliensis was detected with high parasite prevalence in these ecotopes (30.7-40.0%). Moreover, peridomicile insect population densities were more than double the average densities of all other settings evaluated (19.17 versus < 8.94 triatomine/man-hour)...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28715142/cholinesterase-inhibition-reduces-arrhythmias-in-asymptomatic-chagas-disease
#3
Renata Rodrigues Teixeira de Castro, Graciema Porphirio, Sergio Salles Xavier, Ruy Silveira Moraes, Elton Luis Ferlin, Jorge Pinto Ribeiro, Antonio Claudio Lucas da Nóbrega
INTRODUCTION: Parasympathetic dysfunction may play a role in the genesis of arrhythmias in Chagas disease. AIM: This study evaluates the acute effects of pyridostigmine (PYR), a reversible cholinesterase inhibitor, on the occurrence of arrhythmias in patients with Chagas cardiac disease. METHOD: Following a double-blind, randomized, placebo-controlled, cross-over protocol, 17 patients (age 50±2 years) with Chagas cardiac disease type B underwent 24-hour Holter recordings after oral administration of either pyridostigmine bromide (45 mg, 3 times/day) or placebo (PLA)...
July 17, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28712508/health-care-importance-of-treponema-pallidum-chagas-disease-and-human-immunodeficiency-virus-1-among-amerindians-of-argentina-an-observational-study
#4
María E Eirin, Cecilia M Delfino, Williams R Pedrozo, Richard Malan, Alberto Puca, Ana M De Rissio, Rogelio D Espejo, María L Gallo Vaulet, Marcelo Rodríguez Fermepin, Mirna M Biglione, Carolina A Berini
The objective of this study was to estimate the prevalence of Treponema pallidum, Trypanosoma cruzi and Human immunodeficiency virus 1 (HIV-1) in five Amerindian populations of Argentina. A retrospective study was conducted among 857 Amerindian populations (112 Kollas, 298 Mbyá-guaraníes, 79 Sagua Huarpes, 368 Wichis) from 2007 to 2010. Screening and confirmation of T. pallidum, T. cruzi and HIV-1 were performed. T. pallidum and T. cruzi infections were detected in all communities with an overall prevalence rate of 4...
July 13, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28710652/comparison-between-inflammation-related-markers-in-peri-implant-crevicular-fluid-and-clinical-parameters-during-osseointegration-in-edentulous-jaws
#5
Amália M Bielemann, Raissa M Marcello-Machado, Fábio Renato Manzolli Leite, Frederico Canato Martinho, Otacílio Luiz Chagas-Júnior, Altair Antoninha Del Bel Cury, Fernanda Faot
OBJECTIVES: The aim of this study is to improve the understanding of interleukin mechanisms during osseointegration to enhance the monitoring of implant failure and success. Clinical parameters, implant stability, and cytokine levels in peri-implant crevicular fluid (PICF) during early bone healing after implant placement were investigated. MATERIAL AND METHODS: Sixty narrow implants were placed in mandible anterior region of 30 edentulous patients (67.23 ± 7...
July 14, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28706938/inhibitors-of-glycosomal-protein-import-provide-new-leads-against-trypanosomiasis
#6
COMMENT
Vishal C Kalel, Leonidas Emmanouilidis, Maciej Dawidowski, Wolfgang Schliebs, Michael Sattler, Grzegorz M Popowicz, Ralf Erdmann
Vector-borne trypanosomatid parasite infections in tropical and sub-tropical countries constitute a major threat to humans and livestock. Trypanosoma brucei parasites are transmitted by tsetse fly and lead to African sleeping sickness in humans and Nagana in cattle. In Latin American countries, Trypanosoma cruzi infections spread by triatomine kissing bugs lead to Chagas disease. Various species of Leishmania transmitted to humans by phlebotomine sandflies manifest in a spectrum of diseases termed Leishmaniasis...
July 3, 2017: Microbial Cell
https://www.readbyqxmd.com/read/28706597/an-infrequent-cause-of-apical-ventricular-aneurysm-in-the-united-states
#7
Mohammed M Taleb
Chronic Chagas cardiomyopathy (CCC) is a late complication of Chagas disease with various manifestations including arrhythmia, heart failure, thromboembolism, and stroke. In a patient with symptoms of heart failure and left ventricular apical aneurysm unexplained by structural heart or coronary vascular abnormalities, CCC should be strongly considered and inquiry made about exposure status. Typical electrocardiographic findings of bundle branch block, complete heart blocks, and ventricular arrhythmia are helpful clues...
April 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/28705488/prevalence-of-trypanosoma-cruzi-infection-in-dogs-and-small-mammals-in-nuevo-le%C3%A3-n-mexico
#8
Lucio Galaviz-Silva, Roberto Mercado-Hernández, José J Zárate-Ramos, Zinnia J Molina-Garza
Chagas disease, caused by the protozoan Trypanosoma cruzi, is an important public health concern in areas extending from South America northward into the southern United States of America. Although this hemoflagellate has many wild and domestic mammalians reported as reservoir hosts, studies on this subject are scarce in Nuevo León state, a region located in northeastern Mexico. This cross-sectional study showed that the general prevalence of T. cruzi infection in Nuevo León state was 14.5% (35/241), this percentage matching the ones determined by PCR and traditional diagnostics...
July 10, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28704745/giant-iatrogenic-pseudoaneurysm-of-the-brachial-artery-a-case-report
#9
Tulio Leite, Márcio Pires, Lucas Pires, Carlos Chagas, Antonio Claudio Oliveira
INTRODUCTION: Pseudoaneurysms are a pulsatile hematoma caused by hemorrhage on soft tissues. It is an uncommon condition with many different etiologies. We report a case of a giant pseudoaneurysm caused by iatrogenic injury on the brachial artery. PRESENTATION OF CASE: A 42 year-old male was submitted to our Vascular Surgery service with an enlargement of the right upper limb and a history of myocardial infarction. 60days before the patient reached our service, he was submitted to a cardiac catheterization performed by another medical team, since the catheter was placed on the right brachial artery near the cubital fossa, we suspected an iatrogenic pseudoaneurysm, which was confirmed by his clinical history and physical exam...
July 3, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28704642/infections-after-shoulder-arthroplasty-are-correlated-with-higher-anesthetic-risk-score-a-case-control-study-in-brazil
#10
Leonardo Hideto Nagaya, Mauro José Costa Salles, Lucas Sadawo Chagas Takikawa, Marcelo Fregoneze, Pedro Doneux, Luciana Andrade da Silva, Guilherme do Val Sella, Alberto Naoki Miyazaki, Sergio Luiz Checchia
PURPOSES: Shoulder arthroplasty (SA) has been performed by many years for the treatment of several conditions, including osteoarthritis and proximal humeral fractures following trauma. Surgical site infection (SSI) following SA remains a challenge, contributing to increased morbidity and costs. Identification of risk factors may help implementing adequate strategies to prevent infection. We aimed to identify pre- and intra-operative risk factors associated with deep infections after SA...
July 10, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28700063/reassessment-of-quality-of-life-domains-in-patients-with-compensated-chagas-heart-failure-after-participating-in-a-cardiac-rehabilitation-program
#11
Mauro Felippe Felix Mediano, Fernanda de Souza Nogueira Sardinha Mendes, Vivian Liane Mattos Pinto, Paula Simplício da Silva, Alejandro Marcel Hasslocher-Moreno, Andrea Silvestre de Sousa
INTRODUCTION: We evaluated the effects of a cardiac rehabilitation program on quality of life. METHODS: This secondary analysis of a single-arm study included 12 patients with Chagas heart failure. The cardiac rehabilitation program comprised exercise training and nutritional and pharmaceutical counseling. Quality of life was assessed using the SF-36 questionnaire. RESULTS: The program promoted improved physical functioning (β= +5.7; p=0...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700051/pharmacotherapeutic-follow-up-of-patients-with-chagas-disease-using-benznidazole-drug-related-problems-and-pharmaceutical-interventions
#12
João Paulo Ramalho Correia, Alanna Carla da Costa, Eduardo Arrais Rocha, Ana Rosa Pinto Quidute, Darlan da Silva Cândido, Ângela Maria de Souza Ponciano, Marta Maria de França Fonteles, Maria de Fátima Oliveira
INTRODUCTION: Benznidazole (BNZ) is a drug available for the etiological treatment of Chagas disease. However, this drug is toxic and has a limited effectiveness on the chronic phase of this disease, often leading to poor treatment adherence. METHODS: This is a descriptive and exploratory study conducted at the Pharmaceutical Care Service for Chagas disease patients of the Federal University of Ceará. Drug-related problems (DRPs) and pharmaceutical interventions (PIs) were classified according to the Second Consensus of Granada...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700045/chagas-disease-review-of-needs-neglect-and-obstacles-to-treatment-access-in-latin-america
#13
Eloan Pinheiro, Lucia Brum-Soares, Renata Reis, Juan-Carlos Cubides
After more than one century since its discovery, Chagas disease is still extremely prevalent in 21 Latin American countries. Chagas disease is one of the most concerning public health problems in Latin America; the overall cost of CD treatment is approximately 7 billion United States dollars per year and it has a strong social impact on populations. Little progress has been made regarding the access to diagnosis and treatment at the primary health care level, calling into question the current policies to ensure the right to health and access to essential medications...
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700043/facing-chagas-disease
#14
EDITORIAL
João Carlos Pinto Dias
No abstract text is available yet for this article.
May 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28700000/ticks-infesting-captive-and-free-roaming-wild-animal-species-at-the-s%C3%A3-o-paulo-zoo-s%C3%A3-o-paulo-brazil
#15
Irys Hany Lima Gonzalez, Marcelo Bahia Labruna, Carolina Romeiro Fernandes Chagas, Paula Andrea Borges Salgado, Cauê Monticelli, Luan Henrique Morais, Amanda Alves de Moraes, Thatiane Cristina Antunes, Patrícia Locosque Ramos, Thiago Fernandes Martins
Ticks are ectoparasites of worldwide distribution that affect vertebrates and can transmit pathogens to animals and humans. The Zoological Park Foundation of São Paulo (FPZSP) is located in a Conservation Unit in one of the most important remaining fragments of the Atlantic Rainforest biome in the suburbs of São Paulo, Brazil. The FPZSP houses more than 3,000 wild animals on exhibit, in breeding programs and in environmental education programs, and also attracts migratory birds and free-roaming wildlife. This study focused on identifying the diversity of tick species that infest captive and free-roaming animals at the FPZSP...
July 10, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28699977/pacemaker-implants-in-children-and-adolescents-with-chagas-disease-in-brazil-18-year-incidence
#16
Carolina Christianini Mizzaci, Thiago Gonçalves Schroder E Souza, Gabriel Pelegrineti Targueta, Ana Paula Frederico Tótora, Juan Carlos Pachón Mateos, José Carlos Pachon Mateos
Background: Chagas disease continues to be a serious public health problem, and accounts for 25-30% of the indications for cardiac stimulation in Brazil. Objective: To assess clinical and epidemiological characteristics of patients with Chagas disease, younger than 18 years, who had undergone pacemaker implantation in Brazil between 1994 and 2011, and its temporal trend. Methods: This was a cross-sectional analysis of data from the Brazilian Pacemaker Registry database...
June 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28697990/avian-antibodies-igy-against-trypanosoma-cruzi-purification-and-characterization-studies
#17
Thirssa H Grando, Matheus D Baldissera, Mariângela F de Sá, Guilherme do Carmo, Bianca Carolina Z Porto, Gisele S V Aguirre, Maria Isabel de Azevedo, Francielli P K de Jesus, Janio M Santurio, Michele R Sagrillo, Lenita Moura Stefani, Silvia Gonzalez Monteiro
Trypanosoma cruzi is a flagellated protozoan belonging to the Trypanosomatidae family, the etiologic agent of Chagas disease. Currently, there is neither a licensed vaccine nor effective treatment, characterizing an unmet clinical need. The IgY refers to the egg yolk immunoglobulin (Y=yolk) and its production and use are subjects of many studies due to the diversity of its diagnostic and therapeutic applications. Several researchers have shown that the use of specific IgY may prevent and/or control infectious and parasitic diseases...
July 8, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28694056/the-involvement-of-rhopr-crf-dh-in-feeding-and-reproduction-in-the-blood-gorging-insect-rhodnius-prolixus
#18
Shirin Mollayeva, Ian Orchard, Angela B Lange
Rhodnius prolixus is a blood-gorging insect and a vector for human Chagas disease. The insect transmits the disease following feeding, when it excretes urine and feces contaminated with the Trypanosoma cruzi parasite. A corticotropin-releasing factor-like peptide acts as a diuretic hormone in R. prolixus (Rhopr-CRF/DH); however, its distribution throughout the insect's central nervous system (CNS) and the expression of its receptor in feeding-related tissue as well as the female reproductive system suggests a multifaceted role for the hormone beyond that of diuresis...
July 7, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28690148/betulinic-acid-induces-cell-death-by-necrosis-in-trypanosoma-cruzi
#19
Paloma Leão Sousa, Racquel Oliveira da Silva Souza, Louise Donadello Tessarolo, Ramon Róseo Paula Pessoa Bezerra de Menezes, Tiago Lima Sampaio, Jader Almeida Canuto, Alice Maria Costa Martins
Chagas' disease is a neglected disease caused by the protozoan parasite Trypanosoma cruzi and constitutes a serious health problem worldwide. The treatment is limited, with variable efficacy of benznidazole and nifurtimox. Betulinic Acid (BA), a triterpene, can be found in medicinal herbs and has a wide variety of biological and pharmacological activities. The objective was to evaluate betulinic acid effects on the cell death mechanism in Trypanosoma cruzi strain Y. BA inhibited the growth of epimastigotes in periods of 24h (IC50=73...
July 6, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28690145/salivary-gland-transcripts-of-the-kissing-bug-panstrongylus-chinai-a-vector-of-chagas-disease
#20
Hirotomo Kato, Ryan C Jochim, Eduardo A Gomez, Shunsuke Tsunekawa, Jesus G Valenzuela, Yoshihisa Hashiguchi
The saliva of blood sucking arthropods contains potent pharmacologically active components to counteract the host hemostatic and inflammatory systems when they take a blood meal. In the present study, dominant salivary gland transcripts of Panstrongylus chinai, a vector of Chagas disease, were analyzed by sequencing randomly selected clones of the salivary gland cDNA library. This analysis showed that 56.5% of the isolated transcripts coded for putative secreted proteins, of which 73.7% coded for proteins belonging to the lipocalin family...
July 6, 2017: Acta Tropica
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