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https://www.readbyqxmd.com/read/29346369/the-rise-of-neglected-tropical-diseases-in-the-new-texas
#1
REVIEW
Peter J Hotez
Within the last five years, the State of Texas has experienced either transmission or outbreaks of Ebola, chikungunya, West Nile, and Zika virus infections. Autochthonous transmission of neglected parasitic and bacterial diseases has also become increasingly reported. The rise of such emerging and neglected tropical diseases (NTDs) has not occurred by accident but instead reflects rapidly evolving changes and shifts in a "new" Texas beset by modern and globalizing forces that include rapid expansions in population together with urbanization and human migrations, altered transportation patterns, climate change, steeply declining vaccination rates, and a new paradigm of poverty known as "blue marble health...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346219/pancreatic-metastases-as-the-initial-manifestation-of-a-neuroendocrine-carcinoma-of-the-uterine-cervix
#2
Maria Ana C B Kopke Túlio, Mariana S F Horta, Miguel C S Bispo, Tiago S N Bana E Costa, Cristina M D B R Chagas
No abstract text is available yet for this article.
February 2018: Pancreas
https://www.readbyqxmd.com/read/29344690/-globalization-challenges-in-abdominal-surgery-for-migrants-and-refugees
#3
REVIEW
T J Wilhelm, S Post
The increasing number of refugees, migrants and international travelers influences the surgical spectrum of abdominal diseases. The aim of this review is to familiarize surgeons with specific diseases which are endemic in the patients' countries of origin and are likely to be diagnosed with increasing incidence in Germany. Low levels of hygiene in the countries of origin or refugee camps is associated with a high incidence of numerous infections, such as helminth infections, typhoid fever or amoebiasis, which if untreated can cause surgical emergencies...
January 17, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29340783/identification-of-bat-trypanosomes-from-minas-gerais-state-brazil-based-on-18s-rdna-and-cathepsin-l-like-targets
#4
Elaine Cristina Bento, César Gómez-Hernández, Lara Rocha Batista, Laís Anversa, André Luiz Pedrosa, Eliane Lages-Silva, Juan David Ramírez, Luis Eduardo Ramirez
Several bat species can be infected by trypanosomes, but there is not much information about which of these parasites infect bats from Triângulo Mineiro and Alto Paranaíba, Minas Gerais state, Brazil, a formerly endemic region for Trypanosoma cruzi, the causative agent of Chagas disease. The aim of this study was to describe, characterize, and identify the presence of trypanosomes in bats. The captured bats (448) belong to four families and to 19 different species. Of those, 37 bats were found to be positive for trypanosomes by microhematocrit, (infection rate 8...
January 16, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29340464/seroprevalence-of-human-trypanosoma-cruzi-infection-in-the-north-of-estado-de-mexico
#5
Saúl González-Guzmán, Sergio Pichardo-Ávila, Eulalia Mimbrera-Rodríguez, José Antonio Crescencio-Trujillo, María de Lourdes Gasca-Leyva, Fernando Martínez-Hernández, Nancy Rivas, Ricardo Alejandre-Aguilar
INTRODUCTION: Chagas disease is a neglected public health problem in Mexico; however, detailed studies to determine the seroprevalence in some states have not been performed. METHODS: A total 1,504 human serum from thirteen communities in Estado de Mexico, were analyzed with three diagnostics techniques. RESULTS: The overall seroprevalence was 9.1%, with high prevalence among people aged 51-60 years, while people aged 0-29 years were seronegative against T...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340462/rhodnius-stali-new-vector-infected-by-trypanosoma-rangeli-kinetoplastida-trypanosomatidae
#6
Gabriela Vieira de Souza Castro, Mariane Albuquerque Lima Ribeiro, Leandro José Ramos, Jader de Oliveira, João Aristeu da Rosa, Luis Marcelo Aranha Camargo, Dionatas Ulises de Oliveira Meneguetti
INTRODUCTION: Rhodnius stali infection by Trypanosoma rangeli is reported in this study for the first time. METHODS: The triatomines were collected from the campus of the Federal University of Acre in Rio Branco, Acre, Brazil. The identification of T. rangeli was confirmed by multiplex polymerase chain reaction. RESULTS: The examinations of two specimens revealed R. stali infection by the epimastigote forms of T. rangeli. CONCLUSIONS: The encounter of R...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340461/synanthropic-triatomines-as-potential-vectors-of-trypanosoma-cruzi-in-central-brazil
#7
Thaís Tâmara Castro Minuzzi-Souza, Nadjar Nitz, César Augusto Cuba Cuba, Marcelo Santalucia, Monique Knox, Luciana Hagström, Camilla Bernardes Furtado, Tamires Emanuele Vital, Marcos Takashi Obara, Mariana Machado Hecht, Rodrigo Gurgel-Gonçalves
INTRODUCTION: Chagas disease surveillance requires current knowledge on synanthropic triatomines. We analyzed the occurrence and Trypanosoma cruzi infection rates of triatomine bugs in central Brazil, during 2012-2014. METHODS: Triatomines were collected inside or around houses, and T. cruzi infection was determined by optical microscopy and conventional/quantitative polymerase chain reaction. RESULTS: Of the 2706 triatomines collected, Triatoma sordida was the most frequent species in Goiás State, whereas Panstrongylus megistus predominated in the Federal District...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340457/diet-quality-of-patients-with-chronic-chagas-disease-in-a-tertiary-hospital-a-case-control-study
#8
Mariana Pereira de Castilhos, Grazielle Vilas Bôas Huguenin, Paulo Rogério Melo Rodrigues, Emília Matos do Nascimento, Basílio de Bragança Pereira, Roberto Coury Pedrosa
INTRODUCTION: Nutritional status has been implicated in the modulation of the immune response, possibly augmenting the pathogenesis of Chagas disease (Cd). We evaluated diet quality and nutritional status in adults and elderly patients with chronic Cd in a tertiary hospital. METHODS: A case-control study of Cd patients was conducted, paired for gender, age, and co-morbidities with non-Cd patients. Anthropometric measurements and food frequency questionnaire was used, and diet quality was assessed by the Brazilian Healthy Eating Index-Revised (BHEI-R)...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340450/therapeutic-drug-monitoring-of-benznidazole-and-nifurtimox-a-systematic-review-and-quality-assessment-of-published-clinical-practice-guidelines
#9
Mario Javier Olivera, Johana Alexandra Fory, Antonio José Olivera
The pharmacological management of adults with chronic-phase Chagas disease is challenging despite it being the recent focus of extensive research. One of the challenges in the current clinical practice guidelines (CPGs) landscape is the existence of non-evidence-based recommendations for the use of laboratory tests in treatment monitoring. This study aimed to systematically assess the quality and consistency of recommendations of CPGs on the pharmacological management of adults with chronic-phase Chagas disease...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340449/the-continuous-challenge-of-chagas-disease-treatment-bridging-evidence-based-guidelines-access-to-healthcare-and-human-rights
#10
EDITORIAL
Alberto Novaes Ramos-Junior, Andréa Silvestre de Sousa
No abstract text is available yet for this article.
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29337988/l-arginine-supplementation-reduces-mortality-and-improves-disease-outcome-in-mice-infected-with-trypanosoma-cruzi
#11
Sofía Carbajosa, Héctor O Rodríguez-Angulo, Susana Gea, Carlos Chillón-Marinas, Cristina Poveda, María C Maza, Diana Colombet, Manuel Fresno, Núria Gironès
Chagas disease caused by Trypanosoma cruzi is a neglected disease that affects about 7 million people in Latin America, recently emerging on other continents due to migration. As infection in mice is characterized by depletion of plasma L-arginine, the effect on infection outcome was tested in mice with or without L-arginine supplementation and treatment with 1400W, a specific inhibitor of inducible nitric oxide synthase (iNOS). We found that levels of L-arginine and citrulline were reduced in the heart and plasma of infected mice, whereas levels of asymmetric dimethylarginine, an endogenous iNOS inhibitor, were higher...
January 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29337878/tetrasubstituted-imidazolium-salts-as-potent-antiparasitic-agents-against-african-and-american-trypanosomiases
#12
Ouldouz Ghashghaei, Nicola Kielland, Marc Revés, Martin C Taylor, John M Kelly, Ornella Di Pietro, Diego Muñoz-Torrero, Belén Pérez, Rodolfo Lavilla
Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts with bulky moieties can display antiparasitic activity against T. cruzi. After developing a facile methodology for the synthesis of tetrasubstituted imidazolium salts from propargylamines and isocyanides, we screened a small library of these adducts against the causative agents of African and American trypanosomiases. These compounds display nanomolar activity against T...
January 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29336553/catalytic-mechanism-of-cruzain-from-trypanosoma-cruzi-as-determined-from-solvent-kinetic-isotope-effects-of-steady-state-and-pre-steady-state-kinetics
#13
Xiang Zhai, Thomas D Meek
Cruzain, an important drug target for Chagas disease, is a member of Clan CA of the cysteine proteases. Understanding the catalytic mechanism of cruzain is vital to the design of new inhibitors. To this end, we have performed pH-rate profiles for substrates and affinity agents, and have determined solvent kinetic isotope effects in pre-steady-state and steady-state modes using three substrates: Cbz-Phe-Arg-AMC, Cbz-Arg-Arg-AMC and Cbz-Arg-Ala-AMC. The pH-rate profile of kcat/Km for Cbz-Arg-Arg-AMC indicated groups of pK1 = 6...
January 16, 2018: Biochemistry
https://www.readbyqxmd.com/read/29332765/aquatic-myofascial-release-applied-after-high-intensity-exercise-increases-flexibility-and-decreases-pain
#14
Viviane Ramos Costa Lêdo, Ana Paula Xavier, Cesar Augustus Zocoler de Souza, Susi Mary de Souza Fernandes, Étria Rodrigues, Érico Chagas Caperuto
OBJECTIVES: To investigate aquatic myofascial release (AMR) effects on flexibility and delayed onset muscle soreness, after high intensity exercises. STUDY DESIGN: 15 participants, control (CON) and intervention (INT), 3 moments, pre (Pre), after (Post) and 50 min after (Post 50/Post AMR). 6 exercises, 5 sets, 15 reps at 85% of 1 maximum repetition, followed, or not, by 50 min of AMR. VARIABLES: Heart rate, lactate, rate of perceived exertion, pain and flexibility...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332591/anti-trypanosoma-cruzi-activity-in-vitro-of-phases-and-isolated-compounds-from-excoecaria-lucida-leaves
#15
Cristiane Franca da Silva, Ania Ochoa Pacheco, Rayane Nogueira Alves, Josean Fechine Tavares, Marcelo Sobral da Silva, Julio Cesar Escalona Arranz
BACKGROUND: Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. This illness is found mainly in 21 Latin American countries and an estimated 8 million people are infected worldwide. The unsatisfactory chemotherapy provokes severe toxicity and resistant strains. Medicinal plants constitute a promising source of new drugs and remedies against all kinds of disorders, mainly infectious diseases arousing interest worldwide. OBJECTIVE: The aim of this study has been the isolation, structural identification and evaluation of the trypanocidal activity of samples present in the Excoecaria lucida Sw...
January 11, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29325909/corrigendum-to-trans-4-methoxy-%C3%AE-nitrostyrene-relaxes-rat-thoracic-aorta-through-a-sgc-dependent-pathway-european-journal-of-pharmacology-807-2017-182-189
#16
Loeste Arruda-Barbosa, Taylena Maria Teófilo, Francisco Chagas Vasconcelos Souza-Neto, Gloria Pinto Duarte, Joyce Karen Lima Vale, Rosivaldo Santos Borges, Pedro Jorge Caldas Magalhães, Saad Lahlou, Saad Lahlou
No abstract text is available yet for this article.
January 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29323468/in-silico-studies-designed-to-select-sesquiterpene-lactones-with-potential-antichagasic-activity-from-an-in-house-asteraceae-database
#17
Chonny Herrera-Acevedo, Luciana Scotti, Marcus Tullius Scotti
Chagas disease is an endemic disease caused by Trypanosoma cruzi, which affects more than eight million people, mostly in the Americas. A search for new treatments is necessary to control and eliminate this disease. Sesquiterpene lactones (SLs) are an interesting group of secondary metabolites characteristic of Asteraceae that have presented a wide range of biological activities. From the ChEMBL database, we selected a diverse set of 4,452, 1,635 and 1,322 structures with tested activity against the three T...
January 11, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29323238/human-complement-receptor-type-1-cr1-protein-levels-and-genetic-variants-in-chronic-chagas-disease
#18
Thaisa Lucas Sandri, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Christian G Meyer, Peter G Kremsner, Iara J de Messias-Reason, Thirumalaisamy P Velavan
Complement is an essential element in both innate and acquired immunity contributing to the immunopathogenesis of many disorders, including Chagas Disease (CD). Human complement receptor 1 (CR1) plays a role in the clearance of complement opsonized molecules and may facilitate the entry of pathogens into host cells. Distinct CR1 exon 29 variants have been found associated with CR1 expression levels, increased susceptibility and pathophysiology of several diseases. In this study, CR1 plasma levels were assessed by ELISA and CR1 variants in exon 29 by sequencing in a Brazilian cohort of 232 chronic CD patients and 104 healthy controls...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322297/nuclear-distribution-of-the-trypanosoma-cruzi-rna-pol-i-subunit-rpa31-during-growth-and-metacyclogenesis-and-characterization-of-its-nuclear-localization-signal
#19
Israel Canela-Pérez, Imelda López-Villaseñor, Ana María Cevallos, Roberto Hernández
Trypanosoma cruzi is the aetiologic agent of Chagas disease. Our research group studies ribosomal RNA (rRNA) gene transcription and nucleolus dynamics in this species of trypanosomes. RPA31 is an essential subunit of RNA polymerase I (Pol I) whose presence is apparently restricted to trypanosomes. Using fluorescent-tagged versions of this protein (TcRPA31-EGFP), we describe its nuclear distribution during growth and metacyclogenesis. Our findings indicate that TcRPA31-EGFP alters its nuclear presence from concentrated nucleolar localization in exponentially growing epimastigotes to a dispersed granular distribution in the nucleoplasm of stationary epimastigotes and metacyclic trypomastigotes...
January 10, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29320490/the-glutamine-synthetase-of-trypanosoma-cruzi-is-required-for-its-resistance-to-ammonium-accumulation-and-evasion-of-the-parasitophorous-vacuole-during-host-cell-infection
#20
Marcell Crispim, Flávia Silva Damasceno, Agustín Hernández, María Julia Barisón, Ismael Pretto Sauter, Raphael Souza Pavani, Alexandre Santos Moura, Elizabeth Mieko Furusho Pral, Mauro Cortez, Maria Carolina Elias, Ariel Mariano Silber
Trypanosoma cruzi, the etiological agent of Chagas disease, consumes glucose and amino acids depending on the environmental availability of each nutrient during its complex life cycle. For example, amino acids are the major energy and carbon sources in the intracellular stages of the T. cruzi parasite, but their consumption produces an accumulation of NH4+ in the environment, which is toxic. These parasites do not have a functional urea cycle to secrete excess nitrogen as low-toxicity waste. Glutamine synthetase (GS) plays a central role in regulating the carbon/nitrogen balance in the metabolism of most living organisms...
January 10, 2018: PLoS Neglected Tropical Diseases
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