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Somayeh Javidanpour, Mahin Dianat, Mohammad Badavi, Seyyed Ali Mard
The incidence of arrhythmias is the main cause of high mortality after myocardial infarction (AMI). The aim of the present study was to determine whether the rosmarinic acid (RA) could reduce the stretch-induced arrhythmias (SIAs) related to overexpression of NCX1 after AMI. Adult male Sprague-Dawley rats were randomly allocated into six groups: Sham, MI (100 mg/kg of isoproterenol (Iso), subcutaneously, on two consecutive days), RA (30 mg/kg, orally, 14 days), and RA (10, 15 and 30 mg/kg, 14 days) + I...
March 30, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Mehmet Haberal, Mahir Kirnap, Oruc N Gokce, Didem Bacanli, Zeynep Ersoy, Mirbek Bayzakov, Adnan Torgay, Handan Ozdemir, Remzi Erdem
OBJECTIVES: Kidney transplant is the best choice for treatment of patients with advanced chronic renal disease. However, small, poorly compliant, and unstable bladders can result in major problems for patients. Here, we aimed to develop and evaluate a new ileobladder model. MATERIALS AND METHODS: Fifteen rats (250-300 g) and 5 pigs (~100 kg) were cared for according to institutional and published guidelines. After general anesthesia, laparotomy was done through midline incision...
February 2018: Experimental and Clinical Transplantation
Haoliang Hu, Lu He, Lanfang Li, Linxi Chen
The G-protein-coupled receptor APJ and its endogenous ligand apelin are widely expressed in many peripheral tissues and central nervous system, including adipose tissue, skeletal muscles and hypothalamus. Apelin/APJ system, involved in numerous physiological functions like angiogenesis, fluid homeostasis and energy metabolism regulation, is notably implicated in the development of different pathologies such as diabetes and its complications. Increasing evidence suggests that apelin regulates insulin sensitivity, stimulates glucose utilization and enhances brown adipogenesis in different tissues associated with diabetes...
September 2016: Molecular Genetics and Metabolism
J F Ashruf, C Ince
Normal functioning of myocardium requires adequate oxygenation, which in turn is dependent on an adequate microcirculation. NADH-fluorimetry enables a direct evaluation of the adequacy of tissue oxygenation while the measurement of quenching of Pd-porphyrine (PpIX) phosphorescence enables quantitative measurement of microvascular pO2. Combination of these two techniques provides information about the relation between microvascular oxygen content and parenchymal oxygen availability in Langendorff hearts. In normal myocardium there is heterogeneity at the microcirculatory level resulting in the existence of microcirculatory weak units, originating at the capillary level, which reoxygenate the slowest upon reoxygenation after an episode of ischemia...
2016: Advances in Experimental Medicine and Biology
Georgeta Ligia Stănescu, Ramona Mihaela NedelcuŢă, Dalia Dop, Radu Diaconu, Gigi Călin, Elena Carmen Niculescu, Cristian Gheonea, Radu Stănescu, Liliana Anghelina, Mihail Relu Stănescu
We present a case of brain abscess necroptically discovered in a 2-year-old child hospitalized in the Pediatrics Clinic of the "Filantropia" Municipal Hospital, Craiova, Romania. The family, with a poor financial situation, reports previous episodes that may be interpreted as comitial crises. Clinically speaking, he presents a height-weight hypertrophia, vitamin D loss rickets, and psychomotor retardation. At the objective examination, we found a weight of 10 500 g (!), second and third degree mesocardiac systolic beat and cardiomegaly in the thorax-cardiac-pulmonary X-ray examination...
2015: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
M Bandini, P Corre, P Huet, R H Khonsari
INTRODUCTION: Pterygoid hamulus syndrome (PHS) is a rare cause of orofacial and oropharyngeal pain. PHS can be associated with a hamulus hypertrophy or with a bursitis of the palatosalpingeus but it has not always an anatomic cause. OBSERVATION: A 36-year-old woman was seen for a constant posterior palatal pain spreading towards oropharynx, increasing during swallowing and lasting for more than 6 months. Physical examination showed an erythema of the soft palate, medially to the hamulus...
December 2015: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
Ozan Gokdogan, Tolgahan Catli, Fikret Ileri
Halitosis is a common and devastating condition, which may affect up to 1/3 of the population. It can be classified either as genuine halitosis, pseudohalitosis, or halitophobia. Genuine halitosis is more common and usually related to an organic pathology such as periodontitis. Malodour molecules such as sulfur compounds that arise from bacterial interactions generate the basis of oral malodour. Pathologies of the tongue, poor oral hygiene, deep caries, cryptic tonsillary hypertrophia, and postnasal drainage are also associated with halitosis...
March 2015: Iranian Journal of Otorhinolaryngology
Sultan Şevik Eliçora, Murat Öztürk, Rukiye Sevinç, Serhan Derin, Aykut Erdem Dinç, Duygu Erdem
OBJECTIVE: Many studies have shown that children with adenoid hypertrophy (AH) are more likely to have chronic otitis media with effusion (COME). However, not every child with AH has COME. In this study, we investigated the socio-demographic risk factors of children who underwent surgery for AH, including a subgroup with COME. Our aim was to identify the factors involved in the development of COME. METHODS: The study population consisted of 170 pediatric patients (118 males, 52 females) who underwent adenoidectomy between 2005 and 2008...
March 2015: International Journal of Pediatric Otorhinolaryngology
Erzsébet Varga, Simona Tünde Marcu, Boglarka Adoryan
The aim of our study was to asses the efficacy of Xanthii spinosi herba in the treatment of rats with benign prostate hypertrophia induced under experimental conditions. Benign prostate hypertrophia (BPH) was induced by per oral (p.o.) administration of testosterone undecanoate (40 mg Undestor capsules) in concentrations of 15 mg/ kg/day and 35 mg/ kg/day. Drug induced BPH was treated with Xanthii spinosi herba as infusion and tincture. Drug induced benign prostate hyperplasia in rats was accompanied by a series of physical changes, like weight increase and shinier fur, and also by behavioral changes (increased appetite, aggression, increased libido)...
2014: Acta Pharmaceutica Hungarica
Y S Martins, R M C Melo, P H A Campos-Junior, J C E Santos, R K Luz, E Rizzo, N Bazzoli
The present study assessed the influence of salinity and temperature on body growth and on muscle cellularity of Lophiosilurus alexaxdri vitelinic larvae. Slightly salted environments negatively influenced body growth of freshwater fish larvae and we observed that those conditions notably act as an environmental influencer on muscle growth and on local expression of hypertrophia and hypeplasia markers (IGFs and PCNA). Furthermore, we could see that salinity tolerance for NaCl 4gl(-)(1) diminishes with increasing temperature, evidenced by variation in body and muscle growth, and by irregular morphology of the lateral skeletal muscle of larvae...
June 1, 2014: General and Comparative Endocrinology
L Cingano, E Aonzo, R Servetto, E Calcagno
AIM: The aim of the present study was to highlight the relationship between the level of oral hygiene and the context in which the patient receives dental treatment, demonstrating that home service is essential and effective to decrease the incidence of periodontal diseases. METHODS: The study was initially conducted on a heterogeneous sample of patients including 48 individuals with psycho-motor deficits. The study included 28 males (58.3%) and 20 females (41.7%) aged between 18 and 50 years, coming from two different sites ("Fa...
November 2013: Minerva Stomatologica
N Ben Rayana-Chekir, S Khochtali, S Yakoubi, F Touzani, F Ben Hadj Hamida
INTRODUCTION: Pachydermoperiostosis or primary hypertrophic osteoarthropathy is a rare cause of ptosis. We report the case of a patient with pachydermoperiostosis and bilateral ptosis. The physiopathology and treatment of this ptosis are discussed. CASE REPORT: A 49-year-old patient was referred to our department with ptosis. He had pachydermia of the face, hands and the feet, digital clubbing and periostosis. Examination of the eyelids showed that palpebral apertures were reduced to less than 4mm bilaterally and that eyelids were markedly thickened...
September 2013: Journal Français D'ophtalmologie
Annemarie Oosting, Naomi van Vlies, Diane Kegler, Lidewij Schipper, Marieke Abrahamse-Berkeveld, Silvia Ringler, Henkjan J Verkade, Eline M van der Beek
Obese individuals have more (hyperplastic) and larger (hypertrophic) adipocytes in their white adipose tissue (WAT) than normal-weight individuals. The difference in cell number emerges early in childhood, suggesting that this is a critical period for being susceptible to obesity. Breast-feeding has been shown to be protective against obesity, and we have previously shown in mice that the physical structure of lipids in human milk may contribute to this protective effect. In the present study, we investigated how differences in the physical structure of lipids in the early diet may modulate adipose tissue development...
January 28, 2014: British Journal of Nutrition
Hongbo Yu, Steve Guofang Shen, Xudong Wang, Lei Zhang, Shilei Zhang
OBJECTIVE: To explore the indication and application of computer-assisted navigation in oral and maxillofacial surgery. PATIENTS AND METHODS: One hundred and four patients including 34 zygomatic-orbital-maxillary fractures, 27 unilateral TMJ ankylosis, 29 craniofacial fibrous dysplasia, 9 mandibular angle hypertrophia, 3 cartilage/bone tumours of jaw and 2 cases with facial foreign bodies were enrolled in this study. CT scans were performed and data was saved in DICOM (digital imaging and communications in medicine) format...
December 2013: Journal of Cranio-maxillo-facial Surgery
Matthias Maruschke, Wolfgang Kram, J Barbara Nebe, Brigitte Vollmar, Annette Zimpfer, Oliver W Hakenberg
BACKGROUND AND AIM: The objective of this study was to establish a rat model to develop hypertrophic fibrosis for subsequent safe application of ureteral stents in order to investigate new treatment options for ureteral strictures. MATERIALS AND METHODS: Thirty-two male Sprague-Dawley rats were used. Group 1: Sham surgery; group 2: surgery with uretero-ureteral anastomosis and stenting. Histopathological evaluation was carried out using 5-bromo-2-deoxyuridine administration before the animals were sacrificed...
March 2013: In Vivo
Hong Wang, Urmila Sreenivasan, Da-Wei Gong, Kelly A O'Connell, Erinne R Dabkowski, Peter A Hecker, Nicoleta Ionica, Manige Konig, Anup Mahurkar, Yezhou Sun, William C Stanley, Carole Sztalryd
Presence of ectopic lipid droplets (LDs) in cardiac muscle is associated to lipotoxicity and tissue dysfunction. However, presence of LDs in heart is also observed in physiological conditions, such as when cellular energy needs and energy production from mitochondria fatty acid β-oxidation are high (fasting). This suggests that development of tissue lipotoxicity and dysfunction is not simply due to the presence of LDs in cardiac muscle but due at least in part to alterations in LD function. To examine the function of cardiac LDs, we obtained transgenic mice with heart-specific perilipin 5 (Plin5) overexpression (MHC-Plin5), a member of the perilipin protein family...
April 2013: Journal of Lipid Research
T J Lam, R J F Felt-Bersma
INTRODUCTION AND HYPOTHESIS: Many women with chronic constipation are referred for anorectal function tests (AFT) when they fail initial conservative treatment with lifestyle advice and laxatives. Our goal was to prospectively investigate the diagnostic potential of AFT in women with constipation in order to identify treatable conditions. METHODS: Between May 2003 and June 2011, all women with constipation referred to our tertiary referral center completed a questionnaire regarding their perianal complaints and underwent physical examination and were evaluated according to our AFT protocol, including anorectal manometry (ARM) and anal endosonography...
January 2013: International Urogynecology Journal
Jens Heyn, Christian Hinske, Patrick Möhnle, Benjamin Luchting, Andres Beiras-Fernandez, Simone Kreth
In spite of enormous efforts, myocardial infarction is one of the most common causes of morbidity and mortality worldwide. The molecular mechanisms underlying the pathological myocardial alterations in affected patients are not fully elucidated. Recent studies have uncovered an important regulatory role for microRNAs (miRNAs), a family of small non-coding RNA molecules which - by translational repression or messenger RNA (mRNA) degradation - primarily act as negative regulators of gene expression. MiRNAs have been identified as regulatory key players during cellular differentiation, proliferation, and apoptosis...
November 2011: Current Vascular Pharmacology
No abstract text is available yet for this article.
October 25, 1947: British Medical Journal (1857-1980)
Libin Liu, Hongyu Zhou
OBJECTIVE: To investigate the effect of myoblast transplantation on duchenne muscular dystrophy (DMD) and to explore the method and feasibility of applying gene therapy to DMD. METHODS: Myoblast of C57/BL10 mice were cultured using multiple-step enzyme digestion method and differential velocity adherent technique. The morphology of the cells was observed with inverted phase contrast microscope. The cells at passage 4 were labeled with 5-BrdU. Twenty-four DMD model mice (mdx mice: aged 4-6 weeks, male, 13...
October 2009: Chinese Journal of Reparative and Reconstructive Surgery
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