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https://www.readbyqxmd.com/read/28228258/clonal-expansion-of-lgr5-positive-cells-from-mammalian-cochlea-and-high-purity-generation-of-sensory-hair-cells
#1
Will J McLean, Xiaolei Yin, Lin Lu, Danielle R Lenz, Dalton McLean, Robert Langer, Jeffrey M Karp, Albert S B Edge
Death of cochlear hair cells, which do not regenerate, is a cause of hearing loss in a high percentage of the population. Currently, no approach exists to obtain large numbers of cochlear hair cells. Here, using a small-molecule approach, we show significant expansion (>2,000-fold) of cochlear supporting cells expressing and maintaining Lgr5, an epithelial stem cell marker, in response to stimulation of Wnt signaling by a GSK3β inhibitor and transcriptional activation by a histone deacetylase inhibitor...
February 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28226316/clinical-evidence-of-increase-in-hair-growth-and-decrease-in-hair-loss-without-adverse-reactions-promoted-by-the-commercial-lotion-ecohair%C3%A2
#2
María Rosario Alonso, Claudia Anesini
BACKGROUND/AIMS: Hair exerts protection, sensory functions, thermoregulation, and sexual attractiveness. Hair loss (alopecia) is caused by several diseases, drug intake, hormone imbalance, stress, and infections (Malassesia furfur). Drugs usually used in alopecia produce irreversible systemic and local side effects. An association of extracts of Coffea arabica and Larrea divaricata (ECOHAIR®) is successfully being commercialized in Argentina for hair growth. The aim of this study was to provide scientific support for the efficacy and innocuousness of ECOHAIR® in patients with noncicatricial alopecia during a 3-month treatment...
February 23, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28223157/dose-dependent-cochlear-and-vestibular-toxicity-of-trans-tympanic-cisplatin-in-the-rat
#3
Angela Callejo, Amandine Durochat, Stéphanie Bressieux, Aurélie Saleur, Christian Chabbert, Ivan Domènech Juan, Jordi Llorens, Sophie Gaboyard-Niay
In vivo studies are needed to study cisplatin ototoxicity and to evaluate candidate protective treatments. Rats and mice are the preferred species for toxicological and pharmacological pre-clinical research, but systemic administration of cisplatin causes high morbidity in these species. We hypothesized that trans-tympanic administration of cisplatin would provide a good model for studying its auditory and vestibular toxicity in the rat. Cisplatin was administered by the trans-tympanic route in one ear (50μl, 0...
February 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28221183/the-effect-of-plasma-rich-in-growth-factors-on-pattern-hair-loss-a-pilot-study
#4
Eduardo Anitua, Ander Pino, Nahikari Martinez, Gorka Orive, Daniel Berridi
BACKGROUND: Autologous growth factors have proved to promote tissue regeneration in various medical fields. Recent findings suggest that platelet rich plasma may also play an important role in hair follicle restoration. OBJECTIVE: The objective of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGFs) for the treatment of androgenetic alopecia (AGA). MATERIALS AND METHODS: Five PRGF injections were administered over 19 patients with AGA...
February 17, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28218299/expression-and-distribution-of-extensins-and-agps-in-susceptible-and-resistant-banana-cultivars-in-response-to-wounding-and-fusarium-oxysporum
#5
Yunli Wu, Wei Fan, Xiaoquan Li, Houbin Chen, Tomáš Takáč, Olga Šamajová, Musana Rwalinda Fabrice, Ling Xie, Juan Ma, Jozef Šamaj, Chunxiang Xu
Banana Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is soil-borne disease of banana (Musa spp.) causing significant economic losses. Extensins and arabinogalactan proteins (AGPs) are cell wall components important for pathogen defence. Their significance for Foc resistance in banana was not reported so far. In this study, two banana cultivars differing in Foc sensitivity were used to monitor the changes in transcript levels, abundance and distribution of extensins and AGPs after wounding and Foc inoculation...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217761/modeling-of-chronic-radiation-induced-cystitis-in-mice
#6
Bernadette M M Zwaans, Sarah Krueger, Sarah N Bartolone, Michael B Chancellor, Brian Marples, Laura E Lamb
PURPOSE: Radiation cystitis (RC), a severe inflammatory bladder condition, develops as a side-effect of pelvic radiation therapy in cancer patients. There are currently no effective therapies to treat RC, in part due to the lack of preclinical model systems. In this study, we developed a mouse model for RC and used a small animal radiation research platform (SARRP) to simulate the targeted delivery of radiation as used with human patients. METHODS AND MATERIALS: To induce RC, C3H mice received a single radiation dose of 20Gy delivered through two beams...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28217548/polygonum-multiflorum-root-extract-as-a-potential-candidate-for-treatment-of-early-graying-hair
#7
Nguyen Dinh Thang, Pham Ngoc Diep, Pham Thi Huong Lien, Le Thi Lien
Despite Polygonum multiflorum (PM) has been experiencely used as a drug to treat early graying hair phenomenon in Asian countries for a long time, there is limited study examined the real biological effects of PM on hair graying in vitro and in vivo. In this study, we investigated the effects of PM root extract (PM-RE) on melanin synthesis in human melanoma SKMEL-28 cells and embryos/larvae of wild-type strain AB zebrafish. We also preliminary revealed the molecular mechanism of early hair graying phenomenon in both in vitro and in vivo models...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28216857/body-image-and-sexuality-in-women-survivors-of-breast-cancer-in-india-qualitative-findings
#8
Michelle S Barthakur, Mahendra P Sharma, Santosh K Chaturvedi, Suraj K Manjunath
OBJECTIVES: With increasing rates of breast cancer survivors, psychosocial issues surrounding cancer survivorship have been gaining prominence. The following article reports on body image and sexuality-related issues in aftermath of the diagnosis and its treatment in the Indian context. MATERIALS AND METHODS: Research design was mixed method, cross-sectional, and exploratory in nature. Quantitative sample consisted of fifty survivors while the qualitative sample size included 15 out of the 50 total breast cancer survivors who were recruited from hospitals, nongovernmental organization, and through word-of-mouth...
January 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28216604/evaluation-of-not-activated-and-activated-prp-in-hair-loss-treatment-role-of-growth-factor-and-cytokine-concentrations-obtained-by-different-collection-systems
#9
Pietro Gentile, John P Cole, Megan A Cole, Simone Garcovich, Alessandra Bielli, Maria Giovanna Scioli, Augusto Orlandi, Chiara Insalaco, Valerio Cervelli
Platelet rich plasma (PRP) was tested as a potential therapy for androgenetic alopecia (AGA) through two different clinical protocols in which one population (18 participants) received half-head treatment with autologous non-activated PRP (A-PRP) produced by CPunT Preparation System (Biomed Device, Modena, Italy) and the other half-head with placebo, and a second separated population in which all participants (n = 6, 3 participants per group) received treatment with calcium-activated PRP (AA-PRP) produced from one of two different PRP collection devices (Regen Blood Cell Therapy or Arthrex Angel System)...
February 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28215594/adult-onset-satoyoshi-syndrome-in-a-young-male
#10
Vinícius Viana Abreu Montanaro, Thiago Falcão Hora, Christian Marques Couto, Flavio Diniz Ribas
Satoyoshi syndrome is a rare condition of presumed autoimmune etiology that is characterized by intermittent painful spasms, diarrhea, hair loss, and bone abnormalities. We report the first case of adult onset Satoyoshi syndrome in South America. A 32-year-old Caucasian male presented with sudden involuntary muscle contractions and painful cramps that had started at the age of 21. He also presented with trismus and complete loss of body hair. Electroneuromyography showed abnormal spontaneous activity. Diagnosis of Satoyoshi syndrome was made after extensive investigation; improvement was achieved with corticosteroids and azathioprine...
January 20, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28213676/-psychosomatic-disorders-of-the-scalp
#11
REVIEW
W Harth
Psychosomatic disorders of the scalp have some special characteristics due to the visibility, possible stigmatization, and amount/patterns of hair. Of practical relevance is trichotillomania, which is now classified as an obsessive-compulsive disorder (OCD). Patients who are obsessed with normal physiological hair loss represent a further psychodermatological challenge. Psychosomatic therapy includes basic psychosomatic care, behavior therapy, or treatment with psychopharmaceuticals.
February 17, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28212278/the-effect-of-the-human-peptide-ghk-on-gene-expression-relevant-to-nervous-system-function-and-cognitive-decline
#12
Loren Pickart, Jessica Michelle Vasquez-Soltero, Anna Margolina
Neurodegeneration, the progressive death of neurons, loss of brain function, and cognitive decline is an increasing problem for senior populations. Its causes are poorly understood and therapies are largely ineffective. Neurons, with high energy and oxygen requirements, are especially vulnerable to detrimental factors, including age-related dysregulation of biochemical pathways caused by altered expression of multiple genes. GHK (glycyl-l-histidyl-l-lysine) is a human copper-binding peptide with biological actions that appear to counter aging-associated diseases and conditions...
February 15, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28211785/continuous-infusion-of-a-large-dose-of-cf-and-5-fu-combined-with-cddp-in-the-treatment-of-advanced-esophageal-cancer
#13
Zheng-Qiu Zhu, Zu-An Zhu, Hong-Xing Cai
5-fluorouracil (5-FU) and cisplatin (CDDP) are common chemotherapy drugs used in the treatment of patients with advanced esophageal cancer. We investigated the efficacy of adding a continuous infusion of a large dose of a common adjuvant, citrovorumfactor (CF), to the traditional 5-FU/wCDDP regimen. 50 patients with advanced esophageal cancer were treated with a continuous infusion of CF, 5-FU, and CDDP, and the short-term effects, adverse reactions, and survival periods after treatment were analyzed. Overall, the treatment was effective in 58% of patients, and the therapeutic effects of the first-line of chemotherapy were significantly better than the second-line (u = 4...
February 17, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28203058/quality-of-life-assessment-in-patients-with-alopecia-areata-and-androgenetic-alopecia-in-the-people-s-republic-of-china
#14
Min Zhang, Nan Zhang
INTRODUCTION: In medical terms, alopecia is considered a relatively mild dermatological condition that nevertheless is a serious condition, but it causes major depression in many sufferers. Alopecia areata (AA) and androgenetic alopecia (AGA) are the main types of hair loss. This study assessed the quality of life (QoL) of Chinese patients with AA and AGA using the Dermatology Life Quality Index (DLQI) questionnaire. METHODS: A total of 178 AA and AGA patients were enrolled in this study, and DLQI was used to evaluate the QoL of the patients...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28196257/association-between-use-of-a-scalp-cooling-device-and-alopecia-after-chemotherapy-for-breast-cancer
#15
Hope S Rugo, Paula Klein, Susan Anitra Melin, Sara A Hurvitz, Michelle E Melisko, Anne Moore, Glen Park, Jules Mitchel, Erika Bågeman, Ralph B D'Agostino, Elizabeth S Ver Hoeve, Laura Esserman, Tessa Cigler
Importance: Chemotherapy-induced alopecia is a common and distressing adverse effect. In previous studies of scalp cooling to prevent chemotherapy-induced alopecia, conclusions have been limited. Objectives: To evaluate whether use of a scalp cooling system is associated with a lower amount of hair loss among women receiving specific chemotherapy regimens for early-stage breast cancer and to assess related changes in quality of life. Design, Setting, and Participants: A prospective cohort study conducted at 5 US medical centers of women with stage I or II breast cancer receiving adjuvant or neoadjuvant chemotherapy regimens excluding sequential or combination anthracycline and taxane (106 patients in the scalp cooling group and 16 in the control group; 14 matched by both age and chemotherapy regimen)...
February 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28196254/effect-of-a-scalp-cooling-device-on-alopecia-in-women-undergoing-chemotherapy-for-breast-cancer-the-scalp-randomized-clinical-trial
#16
Julie Nangia, Tao Wang, Cynthia Osborne, Polly Niravath, Kristen Otte, Steven Papish, Frankie Holmes, Jame Abraham, Mario Lacouture, Jay Courtright, Richard Paxman, Mari Rude, Susan Hilsenbeck, C Kent Osborne, Mothaffar Rimawi
Importance: Chemotherapy may induce alopecia. Although scalp cooling devices have been used to prevent this alopecia, efficacy has not been assessed in a randomized clinical trial. Objectives: To assess whether a scalp cooling device is effective at reducing chemotherapy-induced alopecia and to assess adverse treatment effects. Design, Setting, and Participants: Multicenter randomized clinical trial of women with breast cancer undergoing chemotherapy...
February 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28194644/ionizing-radiation-blocks-hair-cell-regeneration-in-zebrafish-lateral-line-neuromasts-by-preventing-wnt-signaling
#17
Rong Li, Guixiang Liao, Guo Yin, Baiyao Wang, Miaohong Yan, Xiaoshan Lin, Wenqing Zhang, Xiaohui Chen, Shasha Du, Yawei Yuan
Loss of hair cells occurs after radiotherapy, which is a major treatment modality for head and neck cancers. In the lateral line neuromasts of zebrafish, hair cells regenerate rapidly from supporting cells after damage from ototoxins. To investigate hair cell regeneration after radiation damage, zebrafish larvae were exposed to radiation, and hair cells were counted and cell proliferation was detected in neuromasts. After irradiation exposure, cell proliferation was inhibited in neuromasts and the number of supporting cells remained stable...
February 13, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28191673/acquired-hair-curling-after-diphenylcyclopropenone-immunotherapy-in-alopecia-areata-patient
#18
S J Choe, B J Kim, J Choi, W S Lee
Contact immunotherapy using diphenylcyclopropenone (DPCP) is commonly used treatment modality for moderate to severe alopecia areata (AA)(1) . The most common side effects associated with topical immunotherapy using DPCP include eczema, hyperpigmentation, hypopigmentation, vitiligo, and cicatricial alopecia. However, we identified an interesting case of a patient whose entire scalp of straight hair (Figure 1A) became curly after DPCP immunotherapy, which has not been reported previously. A 24-year-old male patient with no specific medical or dermatological history reported to our dermatology outpatient clinic because of sudden hair loss and started treatment after being diagnosed with AA...
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28188805/sphingosine-1-phosphate-signaling-axis-mediates-fibroblast-growth-factor-2-induced-proliferation-and-survival-of-murine-auditory-neuroblasts
#19
Marina Bruno, Ilaria Maria Rizzo, Ricardo Romero-Guevara, Caterina Bernacchioni, Francesca Cencetti, Chiara Donati, Paola Bruni
Hearing loss affects millions of people in the world. In mammals the auditory system comprises diverse cell types which are terminally differentiated and with no regenerative potential. There is a tremendous research interest aimed at identifying cell therapy based solutions or pharmacological approaches that could be applied therapeutically alongside auditory devices to prevent hair cell and neuron loss. Sphingosine 1-phosphate (S1P) is a pleiotropic bioactive sphingolipid that plays key role in the regulation of many physiological and pathological functions...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28177361/effects-of-temperament-on-physiological-productive-and-reproductive-responses-in-beef-cows
#20
R F Cooke, K M Schubach, R S Marques, R F G Peres, L G T Silva, R S Carvalho, R S Cipriano, D W Bohnert, A V Pires, J L M Vasconcelos
This experiment evaluated the effects of temperament on physiological, productive, and reproductive responses in beef cows. A total of 953 lactating, multiparous, non-pregnant Nelore cows (age = 99 ± 2 mo; days post-partum = 51.4 ± 0.3 d; BCS = 5.34 ± 0.04; BW = 430 ± 2 kg) were allocated into 8 groups of approximately 120 cows each. Groups were assigned to an estrus synchronization + timed-AI protocol at the beginning of the breeding season. Concurrently with AI, blood samples were collected, hair samples were clipped from the tail switch, and cow temperament was evaluated via chute score and exit velocity...
January 2017: Journal of Animal Science
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