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schizophrenia nutrition

M Hamza, S Halayem, R Mrad, S Bourgou, F Charfi, A Belhadj
BACKGROUND: The etiology of autism spectrum disorders (ASD) is complex and multifactorial, and the roles of genetic and environmental factors in its emergence have been well documented. Current research tends to indicate that these two factors act in a synergistic manner. The processes underlying this interaction are still poorly known, but epigenetic modifications could be the mediator in the gene/environment interface. The epigenetic mechanisms have been implicated in susceptibility to stress and also in the pathogenesis of psychiatric disorders including depression and schizophrenia...
September 27, 2016: L'Encéphale
Giovanni Casella, Roberta Pozzi, Marta Cicognetti, Francesco Bachetti, Gabriele Torti, Moris Cadei, Vincenzo Villanacci, Vittorio Baldini, Gabrio Bassotti
The association between gluten related disorders and psychiatric diseases has been firmly demonstrated. Non celiac gluten sensitivity (NCGS) is a syndrome diagnosed in patients responsive to gluten free diet after ruling out celiac disease and wheat allergy. The pathogenesis of neuro-psychiatric disorders in NCGS is unclear. An association between gluten and schizophrenia was described for the first time in 1950 by Bender et al. In the 50', Dicke noted that gluten free diet improved mood in celiac patients...
September 20, 2016: Minerva Gastroenterologica e Dietologica
Natalie Parletta, Yousef Aljeesh, Bernhard T Baune
BACKGROUND: People with chronic mental illness have poorer physical health and higher mortality than the general population. We investigated lifestyle factors in people with mental illness across four countries and compared with a normative sample. DESIGN AND METHODS: Data were collected from N = 672 people (Germany, n = 375; Palestine, n = 192; London, n = 63; Australia, n = 42) with substance abuse disorder (n = 224), schizophrenia (n = 158), mood disorders (n = 227), and somatoform disorders (n = 63)...
2016: Frontiers in Psychiatry
Mugtaba Osman, Vekneswaran Devadas
Dysphagia is listed as a 'rare' side effect following clozapine treatment. In this case report, we describe how significant clozapine-induced dysphagia has led to significant reduction of nutritional intake with subsequent substantial weight loss. An 18-year-old single man with an established diagnosis of treatment-resistant paranoid schizophrenia recovered well on a therapeutic dose of clozapine. However, he was noted to lose weight significantly (up to 20% of his original weight) as the dose was uptitrated...
2016: BMJ Case Reports
Nidhi Malhotra, Parmanand Kulhara, Subho Chakrabarti, Sandeep Grover
BACKGROUND & OBJECTIVES: Though studies have reported high prevalence rates of metabolic syndrome among patients with bipolar disorder (BPAD) and schizophrenia, there is lack of data on the impact of the same on the patients' life. This study was aimed to assess the lifestyle related factors associated with metabolic syndrome (MetS) and to study the impact of MetS on functioning and quality of life (QOL) in patients with BPAD and schizophrenia. METHODS: A total of 102 patients with BPAD and 72 patients with schizophrenia attending the output unit of a tertiary care hospital in north India were evaluated for MetS...
April 2016: Indian Journal of Medical Research
Alexandra I Zugno, Lara Canever, Alexandra S Heylmann, Patrícia G Wessler, Amanda Steckert, Gustavo A Mastella, Mariana B de Oliveira, Louyse S Damázio, Felipe D Pacheco, Octacílio P Calixto, Flávio P Pereira, Tamires P Macan, Thayara H Pedro, Patrícia F Schuck, João Quevedo, Josiane Budni
Recent studies have shown benefits for the supplementation of folic acid in schizophrenic patients. The aim of this study was to evaluate the effects of folic acid addition on adult rats, over a period of 7 or 14 days. It also sets out to verify any potential protective action using an animal model of schizophrenia induced by ketamine, in behavioral and biochemical parameters. This study used two protocols (acute and chronic) for the administration of ketamine at a dose of 25 mg/kg (i.p.). The folic acid was given by oral route in doses of 5, 10 and 50 mg/kg, once daily, for 7 and/or 14 days in order to compare the protective effects of folic acid...
October 2016: Journal of Psychiatric Research
Nobumi Miyake, Seiya Miyamoto
Oxidative stress and neuroinflammation have recently been focused on the pathological hypotheses of schizophrenia. N-acetylcysteine (NAC) is a precursor of endogenous antioxidant glutathione and has antioxidant, anti-inflammatory, and neuroprotective properties. NAC is widely available as an over-the-counter nutritional supplement. Increasing lines of evidence suggest that NAC is effective for various mental disorders. In randomized controlled trials, treatment with NAC as an add-on to antipsychotics showed beneficial effects and safety profiles in patients with chronic schizophrenia...
April 2016: Nihon Shinkei Seishin Yakurigaku Zasshi, Japanese Journal of Psychopharmacology
Miriam Schneider, Beth Levant, Martin Reichel, Erich Gulbins, Johannes Kornhuber, Christian P Müller
Psychiatric disorders like mood disorders, schizophrenia, or drug addiction affect a sizeable proportion of the human population and severely compromise quality of life. Therefore, measures to prevent the manifestation, and treatments to ameliorate the symptoms, of these disorders are in high demand. Brain lipids determine the localization and function of proteins in the cell membrane of neurons. Lipids may also act as neurotransmitters or other signalling molecules. The lipid composition of the brain can be influenced by nutrition, environmental factors, and by behavioural activity...
June 16, 2016: Neuroscience and Biobehavioral Reviews
Ramesh Chand Chauhan, Sanjay Kumar Rai, Shashi Kant, Rakesh Lodha, Nand Kumar, Neelima Singh
BACKGROUND: Due to wider access to and free antiretroviral therapy (ART) program, the number of children dying due to acquired immune deficiency syndrome (AIDS)-related causes has declined and the nature and duration of human immunodeficiency virus (HIV)/AIDS caregiving has also dramatically altered. The care of children living with HIV/AIDS (CLHA) places a significant additional burden on the caregivers. AIMS: This study was conducted to assess the perceived burden among caregivers of children living with HIV in North India...
March 2016: North American Journal of Medical Sciences
Justin Davis, Harris Eyre, Felice N Jacka, Seetal Dodd, Olivia Dean, Sarah McEwen, Monojit Debnath, John McGrath, Michael Maes, Paul Amminger, Patrick D McGorry, Christos Pantelis, Michael Berk
Schizophrenia risk has often been conceptualized using a model which requires two hits in order to generate the clinical phenotype-the first as an early priming in a genetically predisposed individual and the second a likely environmental insult. The aim of this paper was to review the literature and reformulate this binary risk-vulnerability model. We sourced the data for this narrative review from the electronic database PUBMED. Our search terms were not limited by language or date of publication. The development of schizophrenia may be driven by genetic vulnerability interacting with multiple vulnerability factors including lowered prenatal vitamin D exposure, viral infections, smoking intelligence quotient, social cognition cannabis use, social defeat, nutrition and childhood trauma...
June 2016: Neuroscience and Biobehavioral Reviews
S L Farhat, C Hochard, S Orens, C Gautier, T Lambert, L Geret, M C Bralet
INTRODUCTION: Schizophrenia causes psychological difficulties (with positive and/or negative symptoms) as well as cognitive disabilities (attention, memory, executive functions and social cognition). Moreover, 40 to 60% of patients suffer from an excess of weight or obesity (due to bad eating habits, eating disorders or medication). All these difficulties impair their autonomy and their insertion into the society. In this context, setting-up a therapeutic tool, which may have cognitive benefits seems relevant...
March 16, 2016: L'Encéphale
Charlotte Hanlon, Atalay Alem, Girmay Medhin, Teshome Shibre, Dawit A Ejigu, Hanna Negussie, Michael Dewey, Lawrence Wissow, Martin Prince, Ezra Susser, Crick Lund, Abebaw Fekadu
BACKGROUND: Task sharing mental health care through integration into primary health care (PHC) is advocated as a means of narrowing the treatment gap for mental disorders in low-income countries. However, the effectiveness, acceptability, feasibility and sustainability of this service model for people with a severe mental disorder (SMD) have not been evaluated in a low-income country. METHODS/DESIGN: A randomised, controlled, non-inferiority trial will be carried out in a predominantly rural area of Ethiopia...
2016: Trials
Takuro Sugai, Yutaro Suzuki, Manabu Yamazaki, Kazutaka Shimoda, Takao Mori, Yuji Ozeki, Hiroshi Matsuda, Norio Sugawara, Norio Yasui-Furukori, Yoshitake Minami, Kurefu Okamoto, Toyoaki Sagae, Toshiyuki Someya
OBJECTIVES: To clarify the prevalence of underweight and overweight/obesity, and laboratory data for nutritional status in Japanese outpatients and inpatients with schizophrenia. DESIGN: Cross-sectional study. SETTING: A questionnaire conducted in inpatient and outpatient facilities in Japan. PARTICIPANTS: The population of adult patients with schizophrenia in Japan (N=23,116). MAIN OUTCOME MEASURES: The prevalence of underweight and undernutrition in Japanese inpatients and outpatients with schizophrenia...
2015: BMJ Open
Claire Chalfoun, Antony D Karelis, Emmanuel Stip, Amal Abdel-Baki
Individuals with schizophrenia have a greater risk for cardiometabolic risk factors (e.g. central obesity, insulin resistance, hypertension and dyslipidaemia), cardiovascular diseases and mortality. This risky profile may be explained by the adverse effects of antipsychotic medications and an unhealthy lifestyle (e.g. smoking, poor nutrition and low physical activity). In the general population, physical activity has been shown to be the optimal strategy to improve both cardiometabolic parameters and cardiorespiratory fitness levels...
August 2016: Journal of Sports Sciences
Silvia Hoirisch-Clapauch, Antonio E Nardi
Tissue plasminogen activator (tPA) mediates a number of processes that are pivotal for synaptogenesis and remodeling of synapses, including proteolysis of the brain extracellular matrix, degradation of adhesion molecules, activation of neurotrophins, and activation of the N-methyl-d-aspartate receptor. Abnormalities in these processes have been consistently described in psychotic disorders. In this paper, we review the physiological roles of tPA, focusing on conditions characterized by low tPA activity, which are prevalent in schizophrenia...
2015: International Journal of Molecular Sciences
Carol A Janney, Rohan Ganguli, Gong Tang, Jane A Cauley, Robert G Holleman, Caroline R Richardson, Andrea M Kriska
OBJECTIVE: Describe objective and subjective physical activity levels and time spent being sedentary in adults with schizophrenia or schizoaffective disorders (SZO/SA). METHOD: Baseline physical activity and sedentary behaviors were assessed among 46 overweight and obese community-dwelling adults (aged 18-70 years; BMI > 27 kg/m(2)) diagnosed with SZO/SA by DSM-IV-TR, with mild symptom severity (Positive and Negative Syndrome Scale score < 90) who were interested in losing weight and participated in the Weight Assessment and Intervention in Schizophrenia Treatment (WAIST) study from 2004 to 2008...
October 2015: Journal of Clinical Psychiatry
John A Naslund, Kelly A Aschbrenner, Emily A Scherer, Sarah I Pratt, Rosemarie S Wolfe, Stephen J Bartels
INTRODUCTION: People with serious mental illness experience elevated severe obesity rates, yet limited evidence documents whether lifestyle intervention participation can benefit these individuals. This study examined the impact of the In SHAPE lifestyle intervention on weight loss among participants with serious mental illness and severe obesity (BMI ≥40) compared with participants who are overweight (BMI 25 to <30) and have class I (BMI 30 to <35) or class II (BMI 35 to <40) obesity...
February 2016: American Journal of Preventive Medicine
Siok Ching Chia, Jeyakumar Henry, Yee Ming Mok, William G Honer, Kang Sim
Current psychopharmacological approaches to reduce psychotic phenomenology in schizophrenia are associated with adverse effects including extrapyramidal and metabolic side effects. In view of the emerging data on nutritional supplementation interventions in schizophrenia which are not entirely consistent, we aimed to review existent studies focusing on fatty acid and vitamin interventions and summarise current evidence on such nutritional supplementations in schizophrenia. We searched the digital databases (ScienceDirect, Scopus, SpringerLINK, PubMed/Medline) for relevant studies pertaining to fatty acid and vitamin supplementation interventions in the management of psychotic symptoms in schizophrenia up to February 2015...
December 2015: Journal of Neural Transmission
Haruyuki Ito, Takako Kumagai, Midori Kimura, Shotaro Koike, Takeshi Shimizu
BACKGROUND: Patients with schizophrenia reportedly have a high prevalence of obesity. One of the reasons is a poor choice of diet. The goal of this study was to clarify characteristics of the dietary intake across the strata of the body mass index (BMI) and to compare the general population and patients with schizophrenia in Japan. METHODS: This is a cross-sectional study of 51 patients with schizophrenia residing in rural areas in 2011. Anthropometric indices (of height, weight, body mass index) were measured at the commencement of the survey...
May 2015: Iranian Journal of Public Health
Astrid Fink, Sandra Cieslak, Frank Rosenbach
OBJECTIVE: To evaluate the effect of non-pharmacological interventions to prevent anti-psychotic medication induced weight gain in patients with a first episode of schizophrenia. METHODS: We searched electronic databases Medline, Embase and PsychINFO and reference lists of articles. Controlled trials evaluating the beneficial effects of non-pharmacological interventions to prevent weight gain were eligible for inclusion. Two authors independently assessed the risk of bias of the studies and extracted data...
October 2015: Psychiatrische Praxis
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