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WDFY-1

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https://www.readbyqxmd.com/read/24549174/e26-transformation-specific-1-ets1-and-wdfy-family-member-4-wdfy4-polymorphisms-in-chinese-patients-with-rheumatoid-arthritis
#1
Yiqun Zhang, Lin Bo, Hui Zhang, Chao Zhuang, Ruiping Liu
E26 transformation-specific-1 (ETS1) and WDFY family member 4 (WDFY4) are closely related with systemic lupus erythematosus. We hypothesized that ETS1 and WDFY4 polymorphisms may contribute to rheumatoid arthritis (RA) susceptibility. We studied ETS1 rs1128334 G/A and WDFY4 rs7097397 A/G gene polymorphisms in 329 patients with RA and 697 controls in a Chinese population. Genotyping was done using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. When the WDFY4 rs7097397 AA homozygote genotype was used as the reference group, the AG genotype was associated with a significantly increased risk for RA...
2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/23149913/autophagy-control-by-the-vegf-c-nrp-2-axis-in-cancer-and-its-implication-for-treatment-resistance
#2
Marissa J Stanton, Samikshan Dutta, Heyu Zhang, Navatha S Polavaram, Alexey A Leontovich, Pia Hönscheid, Frank A Sinicrope, Donald J Tindall, Michael H Muders, Kaustubh Datta
A major contributor to cancer mortality is recurrence and subsequent metastatic transformation following therapeutic intervention. Therefore, in order to develop new treatment modalities and improve the efficacy of current ones, it is important to understand the molecular mechanisms that promote resistance to therapy in cancer cells. One pathway contributing to therapy resistance is autophagy, a self-digestive process that can eliminate unnecessary or damaged organelles to protect cancer cells from death. We have found that the VEGF-C/NRP-2 axis is involved in the activation of autophagy, which helps cancer cell survival following treatment...
January 1, 2013: Cancer Research
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