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https://www.readbyqxmd.com/read/28926969/cardiovascular-activity-of-the-chemical-constituents-of-essential-oils
#1
REVIEW
Tadeu Uggere de Andrade, Girlandia Alexandre Brasil, Denise Coutinho Endringer, Flávio Rogério da Nóbrega, Damião Pergentino de Sousa
Cardiovascular diseases are a leading cause of death in developed and developing countries and decrease the quality of life, which has enormous social and economic consequences for the population. Recent studies on essential oils have attracted attention and encouraged continued research of this group of natural products because of their effects on the cardiovascular system. The pharmacological data indicate a therapeutic potential for essential oils for use in the treatment of cardiovascular diseases. Therefore, this review reports the current studies of essential oils chemical constituents with cardiovascular activity, including a description of their mechanisms of action...
September 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925364/generation-and-characterization-of-a-human-ipsc-line-from-a-patient-with-propionic-acidemia-due-to-defects-in-the-pcca-gene
#2
Esmeralda Alonso-Barroso, Sandra Brasil, Álvaro Briso-Montiano, Rosa Navarrete, Celia Pérez-Cerdá, Magdalena Ugarte, Belén Pérez, Lourdes R Desviat, Eva Richard
Human induced pluripotent stem cell (iPSC) line was generated from fibroblasts of a patient with propionic acidemia carrying mutations in the PCCA gene: c.1899+4_1899+7delAGTA; p.(Cys616_Val633del) and c.1430--?_1643+?del; p.(Gly477Glufs*9). Reprogramming factors OCT3/4, SOX2, KLF4 and c-MYC were delivered using a non-integrative method based on the Sendai virus. Once established, iPSCs have shown full pluripotency, differentiation capacity and genetic stability.
August 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28910583/performance-evaluation-of-startup-for-a-yeast-membrane-bioreactor-mbry-treating-landfill-leachate
#3
Míriam C S Amaral, Rosimeire F Gomes, Yara L Brasil, Sílvia M A Oliveira, Wagner G Moravia
The startup process of a membrane bioreactor inoculated with yeast biomass (Saccharomyces cerevisiae) and used in the treatment of landfill leachate was evaluated. The yeast membrane bioreactor (MBRy) was inoculated with an exogenous inoculum, a granulated active dry commercial bakers' yeast. The MBRy was successfully started up with a progressive increase in the landfill leachate percentage in the MBRy feed and the use of Sabouraud Dextrose Broth. The membrane plays an important role in the startup phase because of its full biomass retention and removal of organic matter...
September 14, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/28902325/interface-between-social-support-quality-of-life-and-depression-in-users-eligible-for-palliative-care
#4
Cissa Azevedo, Juliana Dias Reis Pessalacia, Luciana Regina Ferreira da Mata, Elma Lourdes Campos Pavone Zoboli, Maria da Graça Pereira
OBJECTIVE: Analyzing the relationship between social support, quality of life and depression in patients eligible for palliative care at Primary Health Care of a municipality in the interior of Minas Gerais, Brazil. METHOD: A correlational cross-sectional study carried out with patients treated in six primary health care units. Data were submitted to descriptive statistical analysis, tests for differences between averages and medians, and correlation tests. The significance level was 0...
August 28, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28902230/chronic-kidney-disease-and-metabolic-syndrome-as-risk-factors-for-cardiovascular-disease-in-a-primary-care-program
#5
Suzana Greffin, Mauro Barros André, Jorge Paulo Strogoff de Matos, Hye Chung Kang, Antonio José Lagoeiro Jorge, Maria Luiza Garcia Rosa, Jocemir Ronaldo Lugon
Introduction: Cardiovascular disease (CVD) is especially prevalent in patients with chronic kidney disease (CKD). Objective: To evaluate the role of CKD and metabolic syndrome (MS), which is a cluster of risk factors for CVD, as predictors of CVD. Methods: Observational, cross-sectional study with a random sample aged 45 or more years extracted from the population assisted by the primary care program in Niterói city in the state of Rio de Janeiro, Brazil...
August 28, 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28899387/cognitive-performance-of-children-living-in-endemic-areas-for-plasmodium-vivax
#6
Laélia M B F Brasil, José L F Vieira, Eliete C Araújo, Pedro P F Piani, Rosa M Dias, Ana M R S Ventura, Bianca C Cabral, Renée C R Santa Brígida, Marcieni A de Andrade
BACKGROUND: The role of repeated episodes of malaria on the cognitive development of children is a relevant issue in endemic areas since it can have a long-lasting impact on individual lifespan. The aim of the current paper was to investigate whether the history of malaria can impair the verbal and performance skills of children living in an endemic area with low transmission of Plasmodium vivax malaria. METHODS: A cross-sectional study was conducted with children living in an endemic area of P...
September 12, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28894572/comparison-between-digital-and-optical-microscopy-analysis-in-a-mouse-gut-inflammation-model
#7
Airton Pereira E Silva, Sylvia Maria Nicolau Campos, Isabelle Mazza Guimarães, Gerlinde Agate Platais Brasil Teixeira
Virtual microscopy is currently widely used for various purposes, such as teaching, archiving, collaborations and research. Although the cost of this technique has reduced, it continues to be expensive for the majority of laboratories in developing countries. The Graduate Program in Pathology at the Federal Fluminense University (Niterói, Brazil) has acquired equipment for virtual microscopy. However, this novel method faced prejudice, as students and technicians were skeptical about its reliability. Thus, the aim of the current study was to evaluate whether virtual microscopy is a reliable method of analysis for our research...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28884318/implications-of-fals-mutations-on-sod1-function-and-oligomerization-in-cell-models
#8
Aline A Brasil, Rayne S S Magalhães, Mariana D C De Carvalho, Isabel Paiva, Ellen Gerhardt, Marcos D Pereira, Tiago F Outeiro, Elis C A Eleutherio
Among the familial forms of amyotrophic lateral sclerosis (fALS), 20% are associated with the Cu,Zn-superoxide dismutase (Sod1). fALS is characterized by the accumulation of aggregated proteins and the increase in oxidative stress markers. Here, we used the non-invasive bimolecular fluorescence complementation (BiFC) assay in human H4 cells to investigate the kinetics of aggregation and subcellular localization of Sod1 mutants. We also studied the effect of the different Sod1 mutants to respond against oxidative stress by following the levels of reactive oxygen species (ROS) after treatment with hydrogen peroxide...
September 7, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28876411/binge-drinking-and-illicit-drug-use-among-adolescent-students
#9
Jakelline Cipriano Dos Santos Raposo, Ana Carolina de Queiroz Costa, Paula Andréa de Melo Valença, Patrícia Maria Zarzar, Alcides da Silva Diniz, Viviane Colares, Carolina da Franca
OBJECTIVE: To estimate the prevalence of illicit drug use and its association with binge drinking and sociodemographic factors among adolescent students. METHODS: This is a cross-sectional study with probabilistic conglomerate sampling, involving 1,154 students, aged 13 to 19 years old, from the public school system, in the city of Olinda, State of Pernambuco, Brazil, carried out in 2014. We used the Youth Risk Behavior Survey questionnaire, validated for use with Brazilian adolescents...
September 4, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28876410/cross-cultural-adaptation-of-the-emic-stigma-scale-for-people-with-leprosy-in-brazil
#10
Fabiane Frota da Rocha Morgado, Erika Maria Kopp Xavier da Silveira, Anna Maria Sales, Lilian Pinheiro Rodrigues do Nascimento, Euzenir Nunes Sarno, José Augusto da Costa Nery, Aldair J Oliveira, Ximena Illarramendi
OBJECTIVE: Describe the process of cross-cultural adaptation of the "Explanatory Model Interview Catalog - Stigma Scale" for people affected by leprosy in Brazil. METHODS: After being authorized by the author of the scale to use it in the national context, we initiated the five steps process of cross-cultural adaptation: (1) translation, (2) synthesis meeting, (3) back-translation, (4) committee of experts and (5) pre-test. The internal consistency of the scale was evaluated using Cronbach's alpha coefficient...
September 4, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28873244/aging-effects-in-the-expression-of-macrophages-in-post-treatment-apical-periodontitis-lesions
#11
Natália Freire de Almeida, Sabrina de Castro Brasil, Dennis de Carvalho Ferreira, Luciana Armada
OBJECTIVES: To evaluate the CD68 immunoexpression in post-treatment apical periodontitis lesions of older patients and compare them with lesions of younger/middle age adults. METHODS: Biopsy specimens from 21 apical periodontitis lesions (12 granulomas and 9 cysts) were selected from older patients and 25 apical periodontitis lesions from younger/middle age adults (12 cysts and 13 granulomas) were selected and analyzed by immunohistochemistry using silanized slides with anti-CD68 antibody...
September 5, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28867401/outbreak-of-human-malaria-caused-by-plasmodium-simium-in-the-atlantic-forest-in-rio-de-janeiro-a-molecular-epidemiological-investigation
#12
Patrícia Brasil, Mariano Gustavo Zalis, Anielle de Pina-Costa, Andre Machado Siqueira, Cesare Bianco Júnior, Sidnei Silva, André Luiz Lisboa Areas, Marcelo Pelajo-Machado, Denise Anete Madureira de Alvarenga, Ana Carolina Faria da Silva Santelli, Hermano Gomes Albuquerque, Pedro Cravo, Filipe Vieira Santos de Abreu, Cassio Leonel Peterka, Graziela Maria Zanini, Martha Cecilia Suárez Mutis, Alcides Pissinatti, Ricardo Lourenço-de-Oliveira, Cristiana Ferreira Alves de Brito, Maria de Fátima Ferreira-da-Cruz, Richard Culleton, Cláudio Tadeu Daniel-Ribeiro
BACKGROUND: Malaria was eliminated from southern and southeastern Brazil over 50 years ago. However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. As the P vivax-like non-human primate malaria parasite species Plasmodium simium is locally enzootic, we performed a molecular epidemiological investigation to determine whether zoonotic malaria transmission is occurring. METHODS: We examined blood samples from patients presenting with signs or symptoms suggestive of malaria as well as from local howler monkeys by microscopy and PCR...
August 31, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28866331/microcystin-lr-exposure-induces-oxidative-damage-in-caenorhabditis-elegans-protective-effect-of-lutein-extracted-from-marigold-flowers
#13
Paula Rossini Augusti, Allana Von Sulzback Brasil, Caroline Souto, Gabriela Göethel, Alessandro de Oliveira Rios, Tatiana Emanuelli, Marilise Escobar Bürger, Solange Cristina Garcia
Microcystin-LR (MIC-LR) is a hepatotoxin, with toxicity mechanisms linked to oxidative stress. Besides, neurotoxic effects of MIC-LR have recently been described. Herein, we evaluated the effects of environmentally important concentrations of MIC-LR (1, 10, 100, 250, and 500 μg/L) on oxidative stress markers and the survival rate of the nematode Caenorhabditis elegans (C. elegans). In addition, a possible protective effect of the carotenoid lutein (LUT) extracted from marigold flowers against MIC-LR toxicity was investigated...
August 31, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28851775/gender-and-psychosocial-factors-associated-with-healthy-lifestyle-in-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil-cohort-a-cross-sectional-study
#14
Ana Luísa Patrão, Maria da Conceição Almeida, Sheila Maria Alvim Matos, Dora Chor, Estela M L Aquino
OBJECTIVES: It has been estimated that over 50% of the premature deaths occurring in Western countries can be attributed to causes rooted in lifestyle. In turn, leading a healthy lifestyle has also been associated with a wide range of psychosocial factors. Today, it is known that these differ among men and women. The present article aimed to identify, from a gender-based perspective, the psychosocial factors associated with healthy lifestyles in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort, the largest study concerning adult health conducted in Latin America to date...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28843060/aggregation-of-risk-indicators-to-cardiometabolic-and-musculoskeletal-health-in-brazilian-adolescents-in-the-periods-2008-09-and-2013-14
#15
Anelise R Gaya, Arieli F Dias, Vanilson B Lemes, Juliana Correa Gonçalves, Priscila A Marques, Gabriela Guedes, Caroline Brand, Adroaldo C A Gaya
OBJECTIVE: To assess the occurrence of an aggregate risk to cardiometabolic and musculoskeletal health of Brazilian adolescents in the period 2008/09 and 2013/14 and to identify whether there are differences in risk between the genders and in these periods. METHODS: This was a trend epidemiological study with a quantitative approach, consisting of a voluntary sample of adolescents from 16 Brazilian states. Data were extracted from the database of Brazil Sports Project (Projeto Esporte Brasil)...
August 23, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28838917/association-between-smoking-and-serum-glyca-and-high-sensitivity-c-reactive-protein-levels-the-multi-ethnic-study-of-atherosclerosis-mesa-and-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#16
Sina Kianoush, Marcio Bittencourt, Paulo Lotufo, Isabela Bensenor, Steven R Jones, Andrew P DeFilippis, Peter Toth, James D Otvos, Martin Tibuakuu, Michael E Hall, Paulo H N Harada, Michael J Blaha
BACKGROUND: Inflammation is suggested to be a central feature of atherosclerosis, particularly among smokers. We studied whether inflammatory biomarkers GlycA and high-sensitivity C-reactive protein are associated with cigarette smoking. METHODS AND RESULTS: A total of 11 509 participants, 6774 from the MESA (Multi-Ethnic Study of Atherosclerosis) and 4735 from ELSA-Brasil (The Brazilian Longitudinal Study of Adult Health) were included. We evaluated the cross-sectional association between multiple measures of smoking behavior and the inflammatory biomarkers, GlycA and high-sensitivity C-reactive protein, using regression models adjusted for demographic, anthropometric, and clinical characteristics...
August 23, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28834531/maxillary-sinus-elevation-surgery-with-chronos-and-autogenous-bone-graft-immunohistochemical-assessment-of-runx2-vegf-trap-and-osteocalcin
#17
Rodrigo Dos Santos Pereira, Fernanda Brasil Boos, Luis Fernado Gorla, Idelmo Rangel Garcia, Roberta Okamoto, Eduardo Hochuli-Vieira
The purpose of this study was to evaluate a composite graft of ChronOS, a beta-tricalcium phosphate (β-TCP), mixed 1:1 with an autogenous bone graft in human maxillary sinus augmentation. A total of 12 maxillary sinuses were grafted with an autogenous bone graft (control group), and 9 maxillary sinuses were grafted with ChronOS mixed 1:1 with an autogenous bone graft (test group). After 6 months, biopsy samples were obtained concurrent to the placement of dental implants and were subjected to histomorphometric and immunohistochemical analyses for Runt-related transcription factor 2 (RUNX2), vascular endothelial growth factor (VEGF), tartrate-resistant acid phosphatase, and osteocalcin...
August 23, 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28832756/multinomial-model-and-zero-inflated-gamma-model-to-study-time-spent-on-leisure-time-physical-activity-an-example-of-elsa-brasil
#18
Aline Araújo Nobre, Marilia Sá Carvalho, Rosane Härter Griep, Maria de Jesus Mendes da Fonseca, Enirtes Caetano Prates Melo, Itamar de Souza Santos, Dora Chor
OBJECTIVE: To compare two methodological approaches: the multinomial model and the zero-inflated gamma model, evaluating the factors associated with the practice and amount of time spent on leisure time physical activity. METHODS: Data collected from 14,823 baseline participants in the Longitudinal Study of Adult Health (ELSA-Brasil - Estudo Longitudinal de Saúde do Adulto ) have been analysed. Regular leisure time physical activity has been measured using the leisure time physical activity module of the International Physical Activity Questionnaire...
August 17, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28827581/asian-zika-virus-strains-target-cd14-blood-monocytes-and-induce-m2-skewed-immunosuppression-during-pregnancy
#19
Suan-Sin Foo, Weiqiang Chen, Yen Chan, James W Bowman, Lin-Chun Chang, Younho Choi, Ji Seung Yoo, Jianning Ge, Genhong Cheng, Alexandre Bonnin, Karin Nielsen-Saines, Patrícia Brasil, Jae U Jung
Blood CD14(+) monocytes are frontline immunomodulators categorized into classical, intermediate or non-classical subsets, and subsequently differentiated into M1 pro- or M2 anti-inflammatory macrophages on stimulation. Although the Zika virus (ZIKV) rapidly establishes viraemia, the target cells and immune responses, particularly during pregnancy, remain elusive. Furthermore, it is unknown whether African- and Asian-lineage ZIKV have different phenotypic impacts on host immune responses. Using human blood infection, we identified CD14(+) monocytes as the primary target for African- or Asian-lineage ZIKV infection...
August 21, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28821371/at-the-intersection-of-place-race-and-health-in-brazil-residential-segregation-and-cardio-metabolic-risk-factors-in-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#20
Sharrelle Barber, Ana V Diez Roux, Letícia Cardoso, Simone Santos, Veronica Toste, Sherman James, Sandhi Barreto, Maria Schmidt, Luana Giatti, Dora Chor
Residential segregation is the spatial manifestation of entrenched socioeconomic and racial inequities and is considered a fundamental cause of racial inequalities in health. Despite the well-documented racialized spatial inequalities that exist in urban areas throughout Brazil, few empirical investigations have examined the link between residential segregation and health and considered its implications for racial health inequalities in this setting. In the present study, we used data from the Brazilian Longitudinal Study of Adult Health (2008-2010) to examine the association between economic residential segregation and two major cardio-metabolic risk factors-hypertension and diabetes...
May 27, 2017: Social Science & Medicine
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