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https://www.readbyqxmd.com/read/28447334/-1-h-nmr-1-h-nmr-t2-edited-and-2d-nmr-in-bipolar-disorder-metabolic-profiling
#1
Sumit Sethi, Mariana Pedrini, Lucas B Rizzo, Maiara Zeni-Graiff, Caroline Dal Mas, Ana Cláudia Cassinelli, Mariane N Noto, Elson Asevedo, Quirino Cordeiro, João G M Pontes, Antonio J M Brasil, Acioly Lacerda, Mirian A F Hayashi, Ronei Poppi, Ljubica Tasic, Elisa Brietzke
BACKGROUND: The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics. METHODS: Metabolomic profiling, employing (1)H-NMR, (1)H-NMR T2-edited, and 2D-NMR spectroscopy and chemometrics of human blood serum samples from patients with bipolar disorder (n = 26) compared with healthy volunteers (n = 50) was performed. RESULTS: The investigated groups presented distinct metabolic profiles, in which the main differential metabolites found in the serum sample of bipolar disorder patients compared with those from controls were lipids, lipid metabolism-related molecules (choline, myo-inositol), and some amino acids (N-acetyl-L-phenyl alanine, N-acetyl-L-aspartyl-L-glutamic acid, L-glutamine)...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28444091/risk-factors-for-mortality-in-ventilator-associated-tracheobronchitis-a-case-control-study
#2
Leonilda Giani Pontes, Fernando Gatti de Menezes, Priscila Gonçalves, Alexandra do Rosário Toniolo, Claudia Vallone Silva, Julia Yaeko Kawagoe, Camila Marques Dos Santos, Helena Maria Fernandes Castagna, Marinês Dalla Valle Martino, Luci Corrêa
Objective: To describe the microbiological characteristics and to assess the risk factors for mortality of ventilator-associated tracheobronchitis in a case-control study of intensive care patients. Methods: This case-control study was conducted over a 6-year period in a 40-bed medical-surgical intensive care unit in a tertiary care, private hospital in São Paulo, Brazil. Case patients were identified using the Nosocomial Infection Control Committee database. For the analysis of risk factors, matched control subjects were selected from the same institution at a 1:8...
2017: Einstein
https://www.readbyqxmd.com/read/28443985/zika-puzzle-in-brazil-peculiar-conditions-of-viral-introduction-and-dissemination-a-review
#3
Cristina Possas, Patricia Brasil, Mauro Ca Marzochi, Amilcar Tanuri, Reinaldo M Martins, Ernesto Ta Marques, Myrna C Bonaldo, Antonio Gp Ferreira, Ricardo Lourenço-de-Oliveira, Rita Maria R Nogueira, Patricia C Sequeira, Keyla Bf Marzochi, Akira Homma
This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28441727/job-strain-and-casual-blood-pressure-distribution-looking-beyond-the-adjusted-mean-and-taking-gender-age-and-use-of-antihypertensives-into-account-results-from-elsa-brasil
#4
Leidjaira Lopes Juvanhol, Enirtes Caetano Prates Melo, Marilia Sá Carvalho, Dóra Chor, José Geraldo Mill, Rosane Härter Griep
Methodological issues are pointed to as the main sources of inconsistencies in studies about the association between job strain and blood pressure (BP)/hypertension. Our aim was to analyze the relationship between job strain and the whole BP distribution, as well as potential differences by gender, age, and use of antihypertensives. Additionally, we addressed issues relating to the operationalization of the exposure and outcome variables that influence the study of their inter-relations. We evaluated the baseline date of 12,038 participants enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) (2008-2010), a multicenter cohort study of 35-74-year-old civil servants...
April 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28441412/the-role-of-climate-and-environmental-variables-in-structuring-bird-assemblages-in-the-seasonally-dry-tropical-forests-sdtfs
#5
Gabriela Silva Ribeiro Gonçalves, Pablo Vieira Cerqueira, Leandro Schlemmer Brasil, Marcos Pérsio Dantas Santos
Understanding the processes that influence species diversity is still a challenge in ecological studies. However, there are two main theories to discuss this topic, the niche theory and the neutral theory. Our objective was to understand the importance of environmental and spatial processes in structuring bird communities within the hydrological seasons in dry forest areas in northeastern Brazil. The study was conducted in two National Parks, the Serra da Capivara and Serra das Confusões National Parks, where 36 areas were sampled in different seasons (dry, dry/rainy transition, rainy, rainy/dry transition), in 2012 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28423137/psychometric-properties-of-the-vulnerability-to-abuse-screening-scale-for-screening-abuse-of-older-adults
#6
Raquel Batista Dantas, Graziella Lage Oliveira, Andréa Maria Silveira
OBJECTIVE: Adapt and evaluate the psychometric properties of the Vulnerability to Abuse Screening Scale to identify risk of domestic violence against older adults in Brazil. METHODS: The instrument was adapted and validated in a sample of 151 older adults from a geriatric reference center in the municipality of Belo Horizonte, State of Minas Gerais, in 2014. We collected sociodemographic, clinical, and abuse-related information, and verified reliability by reproducibility in a sample of 55 older people, who underwent re-testing of the instrument seven days after the first application...
April 10, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28419716/effect-of-dehydration-and-rehydration-intervals-on-fracture-resistance-of-reattached-tooth-fragments-using-a-multimode-adhesive
#7
Déborah Lousan do Nascimento Poubel, Júlio César Franco Almeida, Ana Paula Dias Ribeiro, Guilherme Brasil Maia, Jesús Maurício Gonzalez Martinez, Fernanda Cristina Pimentel Garcia
BACKGROUND/AIMS: The tooth fragment bonding technique, frequently used to restore traumatized teeth, may be affected by dehydration/rehydration periods. The aim of this study was to evaluate the effects of different dry and wet storage intervals on multimode adhesive bonding between reattached fragments and teeth. MATERIALS AND METHODS: Eighty-four bovine incisors were fractured and randomized into groups (n=12). After teeth fracturing, each specimen was assigned to one of the following groups: G0: control group (sound tooth); GA1 and GA2: 1-h dehydration and a 15-min or 24-h rewetting period, respectively; GB1 and GB2: 24-h dehydration and a 15-min or 24-h rewetting period, respectively; and GC: 1-h (GC1) or 24-h (GC2) dehydration period only...
April 17, 2017: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/28418232/high-pre-exposure-prophylaxis-uptake-and-early-adherence-among-men-who-have-sex-with-men-and-transgender-women-at-risk-for-hiv-infection-the-prep-brasil-demonstration-project
#8
Brenda Hoagland, Ronaldo I Moreira, Raquel B De Boni, Esper G Kallas, José Valdez Madruga, Ricardo Vasconcelos, Silvia Goulart, Thiago S Torres, Luana M S Marins, Peter L Anderson, Paula M Luz, Iuri da Costa Leite, Albert Y Liu, Valdilea G Veloso, Beatriz Grinsztejn
INTRODUCTION: The efficacy of pre-exposure prophylaxis (PrEP) in preventing sexual acquisition of human immunodeficiency virus (HIV) is well established. Little is known about the feasibility of PrEP implementation in middle-income settings with concentrated epidemics among men who have sex with men (MSM) and transgender women (TGW). METHODS: PrEP Brasil is a prospective, multicentre, open-label demonstration project assessing PrEP delivery in the context of the Brazilian Public Health System...
April 6, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28411891/recombinant-expression-of-thermobifida-fusca-e7-lpmo-in-pichia-pastoris-and-escherichia-coli-and-their-functional-characterization
#9
Kelly B Rodrigues, Jéssica K A Macêdo, Tallyta Teixeira, Jéssica S Barros, Ana C B Araújo, Fernanda P Santos, Betânia F Quirino, Bruno S A F Brasil, Thaís F C Salum, Patrícia V Abdelnur, Léia C L Fávaro
The discovery of lytic polysaccharides monooxygenases copper dependent (LPMOs) revolutionized the classical concept that the cleavage of cellulose is a hydrolytic process in recent years. These enzymes carry out oxidative cleavage of cellulose (and other polysaccharides), acting synergistically with cellulases and other hydrolases. In fact, LPMOs have the potential for increasing the efficiency of the lignocellulosic biomass conversion in biofuels and high value chemicals. Among a small number of microbial LPMOs that have been characterized, some LPMOs were expressed and characterized biochemically from the bacteria Thermobifida fusca, using the host Escherichia coli...
April 9, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28403371/development-of-a-theoretical-practical-script-for-clinical-simulation
#10
Renata Paula Fabri, Alessandra Mazzo, José Carlos Amado Martins, Ariadne da Silva Fonseca, César Eduardo Pedersoli, Fernanda Berchelli Girão Miranda, Laís Fumincelli, Rui Carlos Negrão Baptista
OBJECTIVE: To develop a theoretical-practical script based on the opinion of experts to be used in simulated clinical activities. METHOD: Qualitative study through analysis of content of interviews with experts on the theme in order to develop the proposed script. Of the 24 invited experts, 12 specialists from educational institutions in Brazil and abroad participated in the study in compliance with the ethical precepts. The experts responded to questions on the characterization of their study attributes and described the items required for the development of a simulated scenario...
April 10, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28403340/fertility-rates-and-perinatal-outcomes-of-adolescent-pregnancies-a-retrospective-population-based-study
#11
Maria de Lourdes de Souza, Fiona Ann Lynn, Linda Johnston, Eduardo Cardoso Teixeira Tavares, Odaléa Maria Brüggemann, Lúcio José Botelho
Objective: analyze trends in fertility rates and associations with perinatal outcomes for adolescents in Santa Catarina, Brazil. Methods: a population-based study covering 2006 to 2013 was carried out to evaluate associations between perinatal outcomes and age groups, using odds ratios, and Chi-squared tests. Results: differences in the fertility rate among female adolescents across regions and time period were observed, ranging from 40.9 to 72...
April 6, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28403338/needs-of-family-caregivers-in-home-care-for-older-adults
#12
Carla Cristiane Becker Kottwitz Bierhals, Naiana Oliveira Dos Santos, Fernanda Laís Fengler, Kamila Dellamora Raubustt, Dorothy Anne Forbes, Lisiane Manganelli Girardi Paskulin
Objective: to reveal the felt and normative needs of primary family caregivers when providing instrumental support to older adults enrolled in a Home Care Program in a Primary Health Service in the South of Brazil. Methods: using Bradshaw's taxonomy of needs to explore the caregiver's felt needs (stated needs) and normative needs (defined by professionals), a mixed exploratory study was conducted in three steps: Descriptive quantitative phase with 39 older adults and their caregiver, using a data sheet based on patient records; Qualitative exploratory phase that included 21 caregiver interviews, analyzed by content analysis; Systematic observation, using an observation guide with 16 caregivers, analyzed by descriptive statistics...
April 6, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28403328/zika-puzzle-in-brazil-peculiar-conditions-of-viral-introduction-and-dissemination-a-review
#13
Cristina Possas, Patricia Brasil, Mauro Ca Marzochi, Amilcar Tanuri, Reinaldo M Martins, Ernesto Ta Marques, Myrna C Bonaldo, Antonio Gp Ferreira, Ricardo Lourenço-de-Oliveira, Rita Maria R Nogueira, Patricia C Sequeira, Keyla Bf Marzochi, Akira Homma
This article discusses the peculiar conditions that favoured the unexpected introduction of Zika virus into the poorest northeastern region of Brazil in 2015, its speed of transmission to other Brazilian states, other Latin American countries and other regions, and the severity of related neurological disorders in newborns and adults. Contrasting with evidence that Zika had so far caused only mild cases in humans in the last six decades, the epidemiological scenario of this outbreak in Brazil indicates dramatic health effects: in 2015, an increase of 20-fold in notified cases of microcephaly and/or central nervous system (CNS) alterations suggestive of Zika congenital infection, followed by an exponential increase in 2016, with 2366 cumulative cases confirmed in the country by the end of December 2016...
April 6, 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28401990/sediment-toxicity-identification-evaluation-tie-phases-i-and-ii-based-on-microscale-bioassays-for-diagnosing-causes-of-toxicity-in-coastal-areas-affected-by-domestic-sewage
#14
Mariana Aliceda Ferraz, Aline Vecchio Alves, Cynthia de Cássia Muniz, Fabio Hermes Pusceddu, Paloma Kachel Gusso-Choueri, Aldo Ramos Santos, Rodrigo Brasil Choueri
Domestic sewage is a major problem in highly urbanized coastal areas worldwide. In the current study, TIE phases I and II were applied to sediment interstitial water (IW) from two locations along the São Paulo coast in southeastern Brazil: the sewage outfall of the city of Santos, a densely urbanized area and a less urbanized area (the city of Bertioga). An adapted microscale sea urchin embryo-larval development bioassay was employed. TIE-I manipulations were (i) EDTA addition, (ii) aeration at modified pH, (iii) C18 solid-phase extraction (SPE), and the (iv) addition of Na2 S2 O3 ...
April 12, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28390091/inhibition-of-tyrosinase-by-4h-chromene-analogues-synthesis-kinetic-studies-and-computational-analysis
#15
Edikarlos M Brasil, Luciana M Canavieira, Érica T C Cardoso, Edilene O Silva, Jerônimo Lameira, José L M Nascimento, Vera L Eifler-Lima, Barbarella de Matos Macchi, Dharmarajan Sriram, Paul V Bernhardt, José Rogério Araújo Silva, Craig M Williams, Cláudio N Alves
Inhibition of mushroom tyrosinase was observed with synthetic dihydropyrano[3,2-b]chromenediones. Among them, DHPC04 displayed the most potent tyrosinase inhibitory activity with a Ki value of 4μM, comparable to the reference standard inhibitor kojic acid. A kinetic study suggested that these synthetic heterocyclic compounds behave as competitive inhibitors for the L-DOPA binding site of the enzyme. Furthermore, molecular modeling provided important insight into the mechanism of binding interactions with the tyrosinase copper active site...
April 8, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28380210/safety-and-health-of-professional-drivers-who-drive-on-brazilian-highways
#16
Fernanda Veruska Narciso, Marco Túlio de Mello
Traffic accidents and resulting injuries and deaths have become a global epidemic. In Brazil, most professional drivers, especially truck drivers, face irregular working hours and can be awake for more than 18 hours/day, which reduces their performance and alertness. In this article, we discuss the laws related to Brazilian professional drivers and their current amendments (No. 12,619/2012 and No. 13,103/2015) in relation to working hours at the wheel and rest breaks, which are vital for the quality of life of drivers and society in general...
March 30, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28380209/health-promotion-in-school-environment-in-brazil
#17
Rogério Lessa Horta, Cristine Scattolin Andersen, Raquel Oliveira Pinto, Bernardo Lessa Horta, Maryane Oliveira-Campos, Marco Antonio Ratzsch de Andreazzi, Deborah Carvalho Malta
OBJECTIVE: Evaluate the school environments to which ninth-year students are exposed in Brazil and in the five regions of the country according to health promotion guidelines. METHODS: Cross-sectional study from 2012, with a representative sample of Brazil and its macroregions. We interviewed ninth-year schoolchildren and managers of public and private schools. We proposed a score of health promotion in the school environment (EPSAE) and estimated the distribution of school members according to this score...
March 30, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28380185/trends-in-asthma-mortality-in-the-0-to-4-year-and-5-to-34-year-age-groups-in-brazil
#18
Gustavo Silveira Graudenz, Dominique Piacenti Carneiro, Rodolfo de Paula Vieira
Objective: To provide an update on trends in asthma mortality in Brazil for two age groups: 0-4 years and 5-34 years. Methods: Data on mortality from asthma, as defined in the International Classification of Diseases, were obtained for the 1980-2014 period from the Mortality Database maintained by the Information Technology Department of the Brazilian Unified Health Care System. To analyze time trends in standardized asthma mortality rates, we conducted an ecological time-series study, using regression models for the 0- to 4-year and 5- to 34-year age groups...
January 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28380160/high-risk-pregnancies-and-factors-associated-with-neonatal-death
#19
Marcela de Oliveira Demitto, Angela Andréia França Gravena, Cátia Millene Dell'Agnolo, Marcos Benatti Antunes, Sandra Marisa Pelloso
OBJECTIVE: To identify the factors associated with intra-hospital neonatal mortality based on the individual characteristics of at-risk pregnant mothers, delivery and newborns. METHOD: This was a cross-sectional epidemiological study of live newborns delivered by women attended at the high-risk outpatient unit of a philanthropic hospital in Maringá, Paraná, Brazil between September 2012 and September 2013. RESULTS: Six hundred and eighty-eight women participated in the study...
April 3, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28377149/evaluation-of-an-association-of-alpha-cypermethrin-and-flufenoxuron-for-tick-control-in-an-area-at-risk-of-brazilian-spotted-fever
#20
José Brites-Neto, Jardel Brasil, Jeferson de Andrade, Gabriele Luciana Saqui
Brazilian spotted fever (BSF) is an endemic anthropozoonosis caused by Gram-negative bacteria (Rickettsia rickettsii) that is associated with the risk of human infection by ticks. In the city of Americana, São Paulo (SP), Brazil, there were 12 cases (67% lethal) between 2004 and 2015. This study evaluated the effectiveness of control over tick infestations in an area at risk of BSF, in a field trial on an association of alpha-cypermethrin (3%) and flufenoxuron (3%) (Tenopa(®)) conducted in Americana. The infestation levels of the target species (Amblyomma sculptum and Amblyomma dubitatum) in the field trial were evaluated through acarological surveys (CO2 traps) on days 0, 22, 43 and 62 after treatment, both in the treatment area and in a control area...
March 27, 2017: Veterinary Parasitology
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