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https://www.readbyqxmd.com/read/28441760/supplementation-with-a-polyphenol-rich-extract-perfload-%C3%A2-improves-physical-performance-during-high-intensity-exercise-a-randomized-double-blind-crossover-trial
#1
Julien Cases, Cindy Romain, Cristian Marín-Pagán, Linda H Chung, José Miguel Rubio-Pérez, Caroline Laurent, Sylvie Gaillet, Emmanuelle Prost-Camus, Michel Prost, Pedro E Alcaraz
Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food supplement, PerfLoad(®), was able to improve metabolic homeostasis and physical performance during high-intensity exercises under anaerobic conditions. The effect of a supplementation has been investigated on fifteen recreationally-active male athletes during a randomized, double-blind and crossover clinical investigation...
April 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28441442/the-effects-of-a-resistance-vs-an-aerobic-single-session-on-attention-and-executive-functioning-in-adults
#2
Ayelet Dunsky, Mona Abu-Rukun, Sharon Tsuk, Tzvi Dwolatzky, Rafi Carasso, Yael Netz
Evidence from recent studies showed that acute aerobic exercise results in improvements in different cognitive functions. The goal of this study was to assess the influence of acute bouts of aerobic versus resistance exercise on attention and executive function in adults. Thirty-nine physically active adults (age = 52±8 yr) served as participants. Each participant visited the laboratory four times: on the first visit participants performed a cognitive test (NeuroTrax) followed by an aerobic fitness assessment, as well as maximal strength test composed of six exercises...
2017: PloS One
https://www.readbyqxmd.com/read/28440912/performance-of-in-silico-tools-for-the-evaluation-of-p16ink4a-cdkn2a-variants-in-cagi
#3
Marco Carraro, Giovanni Minervini, Manuel Giollo, Yana Bromberg, Emidio Capriotti, Rita Casadio, Roland Dunbrack, Lisa Elefanti, Pietro Fariselli, Carlo Ferrari, Julian Gough, Panagiotis Katsonis, Emanuela Leonardi, Olivier Lichtarge, Chiara Menin, Pier Luigi Martelli, Abhishek Niroula, Lipika R Pal, Susanna Repo, Maria Chiara Scaini, Mauno Vihinen, Qiong Wei, Qifang Xu, Yuedong Yang, Yizhou Yin, Jan Zaucha, Huiying Zhao, Yaoqi Zhou, Steven E Brenner, John Moult, Silvio C E Tosatto
Correct phenotypic interpretation of variants of unknown significance for cancer-associated genes is a diagnostic challenge as genetic screenings gain in popularity in the next-generation sequencing era. The Critical Assessment of Genome Interpretation (CAGI) experiment aims to test and define the state of the art of genotype-phenotype interpretation. Here, we present the assessment of the CAGI p16INK4a challenge. Participants were asked to predict the effect on cellular proliferation of ten variants for the p16INK4a tumor suppressor, a cyclin-dependent kinase inhibitor encoded by the CDKN2A gene...
April 25, 2017: Human Mutation
https://www.readbyqxmd.com/read/28440716/exercise-reduced-pentraxin-3-levels-produced-by-endotoxin-stimulated-human-peripheral-blood-mononuclear-cells-in-obese-individuals
#4
Aaron L Slusher, Yoshimi Shibata, Michael Whitehurst, Arun Maharaj, Justin M Quiles, Chun-Jung Huang
The purpose of this study was to determine whether obesity would reduce the capacity of peripheral blood mononuclear cells (PBMCs) to produce the anti-inflammatory protein pentraxin 3 (PTX3) in response to ex vivo stimulation with lipopolysaccharide (LPS), and if acute aerobic exercise would enhance this PTX3 production capacity. In addition, the inter-relationships of LPS-induced PTX3 with the inflammatory cytokines (interleukin 6 [IL-6], IL-10, and tumor necrosis factor alpha) were examined. Twenty-one healthy subjects (10 obese and 11 normal-weight) performed an acute bout of aerobic exercise at 75% VO2max...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28440572/feasibility-of-a-multidisciplinary-intervention-to-help-cancer-patients-return-to-work
#5
M C J Leensen, I F Groeneveld, T Rejda, P Groenenboom, S van Berkel, T Brandon, A G E M de Boer, M H W Frings-Dresen
This study evaluates feasibility of a multidisciplinary intervention combining occupational counselling with physical exercise to enhance cancer patients' return to work, assesses whether care providers and patients were satisfied with the intervention, and describes barriers to and facilitators of execution. Newly diagnosed cancer patients, treated with chemotherapy and on sick leave from (self-)employment participated. Patients received counselling from an oncological occupational physician (OOP), were assessed by a sports physician, and performed a 12-week training programme supervised by physiotherapists...
April 25, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28440565/lower-limb-muscle-function-and-exercise-performance-in-lung-cancer
#6
EDITORIAL
Matthew Maddocks, Catherine Granger
No abstract text is available yet for this article.
April 25, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28439784/practical-calculation-method-to-estimate-the-absolute-boron-concentration-in-tissues-using-18-f-fbpa-pet
#7
Tadashi Watabe, Kohei Hanaoka, Sadahiro Naka, Yasukazu Kanai, Hayato Ikeda, Masanao Aoki, Eku Shimosegawa, Mitsunori Kirihata, Jun Hatazawa
PURPOSE: The purpose of this study was to establish a practical method to estimate the absolute boron concentrations in the tissues based on the standardized uptake values (SUVs) after administration of 4-borono-phenylalanine (BPA) using 4-borono-2-(18)F-fluoro-phenylalanine ((18)F-FBPA) PET. METHODS: Rat xenograft models of C6 glioma (n = 7, body weight 241 ± 28.0 g) were used for the study. PET was performed 60 min after intravenous injection of (18)F-FBPA (30...
April 24, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28439471/exergames-for-women-with-fibromyalgia-a-randomised-controlled-trial-to-evaluate-the-effects-on-mobility-skills-balance-and-fear-of-falling
#8
Daniel Collado-Mateo, Francisco J Dominguez-Muñoz, Jose C Adsuar, Eugenio Merellano-Navarro, Narcis Gusi
BACKGROUND: Exergames are a new form of rehabilitation that combine the characteristics of physical exercise and the benefits of non-immersive virtual reality (VR). Effects of this novel therapy in women fibromyalgia are still unknown. The objective was to evaluate the effects of exergame-based intervention on mobility skills, balance and fear of falling in women with fibromyalgia. METHODS: This study was a randomized controlled trial with concealed allocation. Seventy-six women with fibromyalgia were divided into two groups: the exercise group received an eight week intervention based on exergames, while the control group continued their usual activities...
2017: PeerJ
https://www.readbyqxmd.com/read/28439212/effect-of-thyme-extract-supplementation-on-lipid-peroxidation-antioxidant-capacity-pgc-1%C3%AE-content-and-endurance-exercise-performance-in-rats
#9
Mostafa Khani, Pezhman Motamedi, Mohammad Reza Dehkhoda, Saeed Dabagh Nikukheslat, Pouran Karimi
BACKGROUND: Athletes have a large extent of oxidant agent production. In the current study, we aimed to determine the influence of thyme extract on the endurance exercise performance, mitochondrial biogenesis, and antioxidant status in rats. METHODS: Twenty male Wistar rats were randomly divided into two groups receiving either normal drinking water (non-supplemented group, n = 10) or thyme extract, 400 mg/kg, (supplemented group, n = 10). Rats in both groups were subjected to endurance treadmill training (27 m/min, 10% grade, 60 min, and 5 days/week for 8 weeks)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28438985/decreased-compliance-in-the-deep-and-superficial-conduit-veins-of-the-upper-arm-during-prolonged-cycling-exercise
#10
Anna Oue, Kohei Sato, Marina Yoneya, Tomoko Sadamoto
We examined whether there is a difference in compliance between the deep and superficial conduit veins of the upper arm in response to prolonged exercise. Eight young men performed cycling exercise at 60% of peak oxygen uptake until rectal temperature had been increased by 1.1°C for 38-48 min. The cross-sectional area (CSA) of the brachial (deep) and basilic (superficial) veins was assessed by ultrasound during a cuff deflation protocol. Compliance (CPL) was calculated as the numerical derivative of the cuff pressure and CSA curve...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28438380/the-role-of-muscle-strengthening-in-exercise-therapy-for-knee-osteoarthritis-a-systematic-review-and-meta-regression-analysis-of-randomized-trials
#11
REVIEW
Cecilie Bartholdy, Carsten Juhl, Robin Christensen, Hans Lund, Weiya Zhang, Marius Henriksen
OBJECTIVES: To analyze if exercise interventions for patients with knee osteoarthritis (OA) following the American College of Sports Medicine (ACSM) definition of muscle strength training differs from other types of exercise, and to analyze associations between changes in muscle strength, pain, and disability. METHODS: A systematic search in 5 electronic databases was performed to identify randomized controlled trials comparing exercise interventions with no intervention in knee OA, and reporting changes in muscle strength and in pain or disability assessed as standardized mean differences (SMD) with 95% confidence intervals (95% CI)...
March 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28438305/cardiovascular-response-to-recreational-hockey-in-middle-aged-men
#12
Zack A Goodman, Scott G Thomas, Robert C Wald, Jack M Goodman
The present study examined the hemodynamic response to recreational pick-up hockey relative to maximal exercise testing in middle-aged men. A total of 23 men with a mean age of 53 ± 7 years were studied. Graded exercise testing on a cycle ergometer determined maximal oxygen consumption, blood pressure (BP), and heart rate (HR). Ambulatory BP and Holter electrocardiographic monitoring was performed during one of their weekly hockey games (mean duration = 45 ± 7.2 minutes): for "On-Ice" responses (PLAY; data recorded while standing immediately after a shift; 8...
April 11, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28438174/exercise-attenuates-neurological-deficits-by-stimulating-a-critical-hsp70-nf-%C3%AE%C2%BAb-il-6-synapsin-i-axis-in-traumatic-brain-injury-rats
#13
Chung-Ching Chio, Hung-Jung Lin, Yu-Feng Tian, Yu-Chieh Chen, Mao-Tsun Lin, Cheng-Hsien Lin, Ching-Ping Chang, Chien-Chin Hsu
BACKGROUND: Despite previous evidence for a potent inflammatory response after a traumatic brain injury (TBI), it is unknown whether exercise preconditioning (EP) improves outcomes after a TBI by modulating inflammatory responses. METHODS: We performed quantitative real-time PCR (qPCR) to quantify the genes encoding 84 cytokines and chemokines in the peripheral blood and used ELISA to determine both the cerebral and blood levels of interleukin-6 (IL-6). We also performed the chromatin immunoprecipitation (ChIP) assay to evaluate the extent of nuclear factor kappa-B (NF-κB) binding to the DNA elements in the IL-6 promoter regions...
April 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28438126/prevalence-of-and-factors-associated-with-myopia-in-inner-mongolia-medical-students-in-china-a-cross-sectional-study
#14
Lan Wang, Maolin Du, He Yi, Shengyun Duan, Wenfang Guo, Peng Qin, Zhihui Hao, Juan Sun
BACKGROUND: To further explore characteristics of myopia and changes in factors associated with myopia among students at Inner Mongolia Medical University. METHODS: Two cross-sectional censuses were conducted in 2011 and 2013. Participants were medical students residing on campus in 2011 and 2013. Logistic regression analysis was performed to ascertain associations with basic information, genetic factors, environmental factors. The χ(2) test was used to test for differences in prevalence between 2011 and 2013...
April 24, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28437380/lifestyle-and-neurocognition-in-older-adults-with-cardiovascular-risk-factors-and-cognitive-impairment
#15
James A Blumenthal, Patrick J Smith, Stephanie Mabe, Alan Hinderliter, Kathleen Welsh-Bohmer, Jeffrey N Browndyke, Pao-Hwa Lin, William Kraus, P Murali Doraiswamy, James Burke, Andrew Sherwood
OBJECTIVE: To determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, without dementia (CIND). METHODS: One hundred sixty adults (Mean = 65.4±6.8 years) with CIND completed neurocognitive assessments of executive function, processing speed, and memory. Objective measures of physical activity using accelerometry, aerobic capacity determined by exercise testing, and dietary habits quantified by the Food Frequency Questionnaire and 4-Day Food Diary to assess adherence to the Mediterranean and DASH diets were obtained to assess direct effects with neurocognition...
April 21, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28436723/asymptomatic-peripheral-artery-disease-can-limit-maximal-exercise-capacity-in-chronic-obstructive-pulmonary-disease-patients-regardless-of-airflow-obstruction-and-lung-hyperinflation
#16
Ernesto Crisafulli, Chiara Scelfo, Panagiota Tzani, Marina Aiello, Giuseppina Bertorelli, Alfredo Chetta
Background Silent/asymptomatic peripheral artery disease may occur in patients with chronic obstructive pulmonary disease, but it is poorly investigated. The primary aim of this study was to evaluate in chronic obstructive pulmonary disease patients the impact of asymptomatic/silent peripheral artery disease on maximal exercise capacity; the secondary aim was to search for predictors of peripheral artery disease. Methods We prospectively enrolled chronic obstructive pulmonary disease outpatients. Data on anthropometric characteristics, lung function, cardiopulmonary exercise test and ankle-brachial index were recorded...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28436583/physical-activity-and-exercise-for-chronic-pain-in-adults-an-overview-of-cochrane-reviews
#17
REVIEW
Louise J Geneen, R Andrew Moore, Clare Clarke, Denis Martin, Lesley A Colvin, Blair H Smith
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as well as more general benefits associated with improved overall physical and mental health, and physical functioning...
April 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28436192/predictors-of-non-pharmacological-intervention-effect-on-cognitive-function-and-behavioral-and-psychological-symptoms-of-older-people-with-dementia
#18
Ting-Jung Hsu, Hui-Te Tsai, An-Chun Hwang, Liang-Yu Chen, Liang-Kung Chen
AIM: Our previous work showed that non-pharmacological interventions could effectively reduce the severity of behavioral and psychological symptoms of dementia (BPSD), while the factors influencing the effect of intervention were less explored. Therefore, the main purpose of the present study was to investigate the predictors of the non-pharmacological intervention effect for old veterans with dementia and BPSD. METHODS: A total of 141 old veterans with dementia living in two veterans' homes in northern Taiwan were recruited...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28436061/resistance-exercise-reduces-memory-impairment-induced-by-monosodium-glutamate-in-male-and-female-rats
#19
Paulo Cesar Oliveira Araujo, Caroline Brandão Quines, Natália Silva Jardim, Marlon Regis Leite, Cristina Wayne Nogueira
NEW FINDINGS: Monosodium glutamate causes cognitive impairment. Resistance exercise is effective against monosodium glutamate induced memory impairment in male and female mice. ABSTRACT: Monosodium glutamate (MSG), a flavor enhancer in diets, causes cognitive impairment in humans. Exercise has been reported to protect against impairment of memory in humans. This study investigated if resistance exercise improves the performance of male and female rats treated with MSG in tests of memory and motor coordination...
April 23, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28435743/effects-of-overground-locomotor-training-on-the-ventilatory-response-to-volitional-treadmill-walking-in-individuals-with-incomplete-spinal-cord-injury-a-pilot-study
#20
Gino S Panza, Andrew A Guccione, Lisa M Chin, Jared M Gollie, Jeffery E Herrick, John P Collins
INTRODUCTION: Although there has been substantial emphasis on the neuromuscular and cardiovascular adaptations following rehabilitation, pulmonary adaptations in individuals with incomplete SCI (iSCI) in response to locomotor training have been less frequently studied. In healthy individuals, effective transition from rest to work is accomplished by a hyperpneic response, which exhibits an exponential curve with three phases. However, the degree to which our current understanding of exercise hyperpnea can be applied to individuals with iSCI is unknown...
2017: Spinal Cord Series and Cases
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