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Omega 3 dry eyes

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https://www.readbyqxmd.com/read/27920494/presence-or-absence-of-ocular-surface-inflammation-directs-clinical-and-therapeutic-management-of-dry-eye
#1
Robert Sambursky
BACKGROUND: The presence of clinically significant inflammation has been confirmed in the tears of 40%-65% of patients with symptoms of dry eye. Ocular surface inflammation may lead to tear film instability, epithelial cell irregularities, and permeability, resulting in chronic symptomatic pain and fluctuating vision as well as negative surgical outcomes. PATIENTS AND METHODS: A retrospective single center medical chart review of 100 patients was conducted. All patients were tested with the InflammaDry test to determine if patients exhibited elevated levels of matrix metalloproteinase 9 (MMP-9)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27817918/a-randomized-double-masked-placebo-controlled-clinical-trial-of-two-forms-of-omega-3-supplements-for-treating-dry-eye-disease
#2
Laura A Deinema, Algis J Vingrys, Chinn Yi Wong, David C Jackson, Holly R Chinnery, Laura E Downie
PURPOSE: To assess the efficacy of 2 forms of oral long-chain omega-3 (ω-3) essential fatty acid (EFA) supplements, phospholipid (krill oil) and triacylglyceride (fish oil), for treating dry eye disease (DED). DESIGN: Randomized, double-masked, placebo-controlled clinical trial. PARTICIPANTS: This study was conducted at a single site and involved 60 participants with mild to moderate DED who were randomized (1:1:1) to 1 of 3 groups: placebo (olive oil), krill oil, or fish oil supplements...
November 3, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27797641/effect-of-omega-3-fatty-acids-dietary-supplementation-on-ocular-surface-and-tear-film-in-diabetic-patients-with-dry-eye
#3
Constantine D Georgakopoulos, Olga E Makri, Dionisios Pagoulatos, Panagiotis Vasilakis, Politimi Peristeropoulou, Vasiliki Kouli, Maria I Eliopoulou, Caterina Psachoulia
OBJECTIVE: The objective of this study was to investigate the effect of dietary supplementation with omega-3 fatty acids on ocular surface and tear film in patients with type 2 diabetes suffering from dry eye. METHODS: Thirty-six patients suffering from type 2 diabetes and moderate to severe dry eye syndrome were included in the study. Patients were assigned to receive omega-3 long-chain polyunsaturated fatty acids for 3 months. Tear film break-up time test, Schirmer-I test, and conjunctival impression cytology analysis were performed on all patients at baseline and after 1 and 3 months...
October 31, 2016: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/27766505/proper-balance-of-omega-3-and-omega-6-fatty-acid-supplements-with-topical-cyclosporine-attenuated-contact-lens-related-dry-eye-syndrome
#4
Ling Wang, Xi Chen, Jingfang Hao, Lu Yang
Essential fatty acids had been applied in the treatment of dry eye syndrome (DES), but the effects of different combinations of fatty acids have not been investigated. 360 long-term contact lens wearers were included in this double-blinded study. Omega-3 and omega-6 fatty acids were combined in different ratios and supplied to the participants that were randomly divided into six groups, and the effects of different essential fatty acids mixture on DES with or without topical cyclosporine were investigated. More than half of long-term contact lens wearers suffered from DES, which were found to be attenuated by oral supplement of properly balanced O3FA and O6FA fatty acid...
October 20, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27499612/characterization-of-the-serological-biomarkers-associated-with-sj%C3%A3-gren-s-syndrome-in-patients-with-recalcitrant-dry-eye-disease
#5
Cynthia Matossian, Joan Micucci
PURPOSE: The purpose was to characterize the biomarkers associated with Sjögren's syndrome (SS) identified in the serological samples of patients with recalcitrant dry eye disease; additionally, the modalities utilized in the treatment of dry eye disease were evaluated for subsets of patients with and without SS. PATIENTS AND METHODS: Data for this retrospective, single-center, pilot study were based on a chart review of 48 sequential patients with recalcitrant dry eye who were evaluated for SS via serological analysis...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27442314/effect-of-oral-re-esterified-omega-3-nutritional-supplementation-on-dry-eyes
#6
Alice T Epitropoulos, Eric D Donnenfeld, Zubin A Shah, Edward J Holland, Michael Gross, William J Faulkner, Cynthia Matossian, Stephen S Lane, Melissa Toyos, Frank A Bucci, Henry D Perry
PURPOSE: To assess the effect of oral re-esterified omega-3 fatty acids on tear osmolarity, matrix metalloproteinase-9 (MMP-9), tear break-up time (TBUT), Ocular Surface Disease Index (OSDI), fluorescein corneal staining, Schirmer score, meibomian gland dysfunction (MGD) stage and omega-3 index in subjects with dry eyes and confirmed MGD. METHODS: This was a multicenter, prospective, interventional, placebo-controlled, double-masked study. Subjects were randomized to receive 4 softgels containing a total of 1680 mg of eicosapentaenoic acid/560 mg of docosahexaenoic acid or a control of 3136 mg of linoleic acid, daily for 12 weeks...
September 2016: Cornea
https://www.readbyqxmd.com/read/27296759/dry-eye-disease-present-challenges-in-the-management-and-future-trends
#7
REVIEW
Zahraa Al-Saedi, Allison Zimmerman, Rinda Devi Bachu, Surajit Dey, Zahoor Shah, Reginald Baugh, Sai H S Boddu
Dry eye disease (DED) is a tear film disorder resulting in hyperosmolarity of the tear film and inflammation of the ocular surface. DED is also referred to as keratoconjunctivitis sicca (KCS) and dry eye syndrome. DED represents a significant public health issue, particularly in older adults, and needs more research and attention. Despite the urgent need for safe and effective pharmacotherapies, there is currently only one approved medication, Restasis®, to tackle DED. In this review article, we present an overview of DED, classification, epidemiology, pathophysiology, diagnosis, and risk factors of DED...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27279739/oral-supplementation-with-a-nutraceutical-formulation-containing-omega-3-fatty-acids-vitamins-minerals-and-antioxidants-in-a-large-series-of-patients-with-dry-eye-symptoms-results-of-a-prospective-study
#8
Jordi Gatell-Tortajada
PURPOSE: To assess the benefits and tolerability of a dietary supplement based on omega-3 fatty acids to relieve dry eye symptoms. METHODS: A total of 1,419 patients (74.3% women, mean age 58.9 years) with dry eye syndrome using artificial tears participated in a 12-week prospective study. Patients were instructed to take 3 capsules/day of the nutraceutical formulation (Brudysec(®) 1.5 g). Study variables were dry eye symptoms (scratchy and stinging sensation, eye redness, grittiness, painful and tired eyes, grating sensation, and blurry vision), conjunctival hyperemia, tear breakup time (TBUT), Schrimer I test, and Oxford grading scheme...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27274193/omega-3-fatty-acid-supplementation-improves-dry-eye-symptoms-in-patients-with-glaucoma-results-of-a-prospective-multicenter-study
#9
Abdullah Kaya, Yakup Aksoy
No abstract text is available yet for this article.
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27227397/influence-of-omega-3-and-6-fatty-acids-on-human-meibomian-gland-epithelial-cells
#10
Yang Liu, Wendy R Kam, David A Sullivan
PURPOSE: Oral supplementation with omega 3 (ω-3) and/or 6 (ω-6) fatty acids (FAs) has been reported to alleviate the signs and symptoms of dry eye disease and to improve the expressibility and quality of meibum, in patients with meibomian gland dysfunction. We tested our hypothesis that these FA effects may reflect a direct FA action on human meibomian gland epithelial cells. METHODS: Immortalized human meibomian gland epithelial cells (IHMGECs) were cultured with ω-3, ω-6, or both FAs together for up to 7 days in the presence or absence of serum...
August 2016: Cornea
https://www.readbyqxmd.com/read/27103781/omega-3-fatty-acid-supplementation-improves-dry-eye-symptoms-in-patients-with-glaucoma-results-of-a-prospective-multicenter-study
#11
Jesús Tellez-Vazquez
PURPOSE: The purpose of this study is to assess the effectiveness and tolerability of a dietary supplement with a combination of omega-3 fatty acids and antioxidants on dry eye symptoms caused by chronic instillation of antihypertensive eye drops in patients with glaucoma. PATIENTS AND METHODS: A total of 1,255 patients with glaucoma and dry eye symptoms related to antiglaucoma topical medication participated in an open-label, uncontrolled, prospective, and multicenter study and were instructed to take three capsules a day of the nutraceutical formulation (Brudypio(®) 1...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27050028/a-randomized-controlled-trial-of-omega-3-fatty-acids-in-rosacea-patients-with-dry-eye-symptoms
#12
Rahul Bhargava, Mini Chandra, Utsav Bansal, Divya Singh, Somesh Ranjan, Shalini Sharma
: Objective or purpose: To evaluate the efficacy of dietary omega-3 fatty acids (O3FAs) in rosacea patients having dry eye symptoms. METHODS: A prospective, interventional, randomized, double-masked, placebo-controlled, multi-centric study was done. Symptomatic patients with rosacea were recruited based on their response to (Dry Eye Scoring System, DESS©); a score of 0-3 was assigned to dry eye-related symptoms like ocular fatigue, blurring of vision, itching or burning, sandy or gritty sensation, and redness, respectively (DESS©)...
April 6, 2016: Current Eye Research
https://www.readbyqxmd.com/read/26903189/an-eye-on-nutrition-the-role-of-vitamins-essential-fatty-acids-and-antioxidants-in-age-related-macular-degeneration-dry-eye-syndrome-and-cataract
#13
Meagen M McCusker, Khayyam Durrani, Michael J Payette, Jeanine Suchecki
Visual impairment is a global epidemic. In developing countries, nutritional deficiency and cataracts continue to be the leading cause of blindness, whereas age-related macular degeneration (AMD) and cataracts are the leading causes in developed nations. The World Health Organization has instituted VISION 2020: "The Right to Sight" as a global mission to put an end to worldwide blindness. In industrialized societies, patients, physicians, researchers, nutritionists, and biochemists have been looking toward vitamins and nutrients to prevent AMD, cataracts, and dry eye syndrome (DES)...
March 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/26520814/structural-characteristics-of-oil-poor-dilutable-fish-oil-omega-3-microemulsions-for-ophthalmic-applications
#14
Nina Lidich, Abraham Aserin, Nissim Garti
Docosahexaenoic acid (DHA) promotes synthesis of anti-inflammatory prostaglandins and relief of dry eye symptoms. However, topical ophthalmic application of DHA is difficult because of its lipophilic property. Therefore, it is important to develop aqueous-based formulation with enhanced capabilities. Novel, unique water-dilutable microemulsions (MEs) were constructed to allow loading of naturally occurring rigid long-chain triglyceride of DHA (TG-DHA). The TG-DHA serves as solubilizate and as the oil phase, therefore preparation is poor in oil...
February 1, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/26322917/short-term-omega-3-fatty-acids-treatment-for-dry-eye-in-young-and-middle-aged-visual-display-terminal-users
#15
Rahul Bhargava, Prachi Kumar, Yogesh Arora
OBJECTIVE: To evaluate the effect of an omega 3 fatty acid (O3FA) oral supplement (2,400 mg/day) for 45 days on dry eye symptoms, tear production, stability, and conjunctival cytology in young and middle-aged visual display terminal (VDT) users. METHODS: Institutional review board approval was obtained, and a randomized, double-blind, interventional study was done; eyes of 256 VDT users were randomized to receive 4 capsules twice daily for 45 days (O3FA group), each containing 180 mg of eicosapentaenoic acid and 120 mg docosahexaenoic acid...
July 2016: Eye & Contact Lens
https://www.readbyqxmd.com/read/26164311/omegas-and-dry-eye-more-knowledge-more-questions
#16
REVIEW
Milton M Hom, Penny Asbell, Brendan Barry
The omega-3 (ω3) and omega-6 (ω6) essential fatty acid knowledge base has been exploding. In the last 5 years, at least 12 clinical trials on ω3 and ω6 supplementation and dry eye disease (DED) were published in the peer-reviewed literature (2010 to 2015), about double the amount published in the 5 years prior. Although there is increasing scientific evidence that supports the potential use of ω3 and ω6 supplementation for DED, there are limited randomized controlled trials to properly inform evidence-based medicine...
September 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/26130187/current-and-emerging-therapeutic-strategies-for-the-treatment-of-meibomian-gland-dysfunction-mgd
#17
REVIEW
Adam R Thode, Robert A Latkany
Meibomian gland (MG) dysfunction (MGD) is a multifactorial, chronic condition of the eyelids, leading to eye irritation, inflammation and ocular surface disease. Initial conservative therapy often includes a combination of warm compresses in addition to baby shampoo or eyelid wipes. The practice of lid hygiene dates back to the 1950s, when selenium sulfide-based shampoo was first used to treat seborrhoeic dermatitis of the eyelids. Today, tear-free baby shampoo has replaced dandruff shampoo for MGD treatment and offers symptom relief in selected patients...
July 2015: Drugs
https://www.readbyqxmd.com/read/26080588/-efficacy-of-conservative-treatment-in-patients-with-dry-form-of-age-related-macular-degeneration
#18
M A Kovalevskaya, S O Milyutkina
AIM: To evaluate the efficacy of conservative treatment in dry AMD patients by means of 3D computer-automated threshold Amsler grid testing (3D-CTAG; Fink & Sadun, 2004). MATERIAL AND METHODS: The study included 90 patients (180 eyes) with dry AMD divided into three groups. Group 1 (n = 30) was prescribed Vitrum Vision forte, 1 tablet b.i.d., group 2 (n = 30)--Vitrum Vision forte, 1 tablet b.i.d. and Vitrum Cardio Omega-3, 1 capsule b.i.d. Group 3 (n = 30), the controls, received Taurine 250 mg, 1 tablet b...
March 2015: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/25999682/a-metabolomic-approach-to-dry-eye-disorders-the-role-of-oral-supplements-with-antioxidants-and-omega-3-fatty-acids
#19
Carmen Galbis-Estrada, Maria Dolores Pinazo-Durán, Sebastián Martínez-Castillo, José M Morales, Daniel Monleón, Vicente Zanon-Moreno
PURPOSE: We used nuclear magnetic resonance spectroscopy of hydrogen-1 nuclei ((1)H NMR S) to analyze the metabolic profile of reflex tears from patients with dry eye disorders. METHODS: We performed a prospective case-control study involving 90 participants: 55 patients diagnosed with dry eye syndrome (DESG) and 35 healthy subjects (control group, CG). From the DESG, two subgroups were formed: mild DES (n=22) and moderate DES (n=33). Participants were prescribed an oral nutraceutic supplementation containing antioxidants and essential polyunsaturated fatty acids to be taken as three capsules per day for 3 months...
2015: Molecular Vision
https://www.readbyqxmd.com/read/25878491/recent-developments-in-the-management-of-dry-age-related-macular-degeneration
#20
REVIEW
Elisa Buschini, Antonio M Fea, Carlo A Lavia, Marco Nassisi, Giulia Pignata, Marta Zola, Federico M Grignolo
Dry age-related macular degeneration (AMD), also called geographic atrophy, is characterized by the atrophy of outer retinal layers and retinal pigment epithelium (RPE) cells. Dry AMD accounts for 80% of all intermediate and advanced forms of the disease. Although vision loss is mainly due to the neovascular form (75%), dry AMD remains a challenge for ophthalmologists because of the lack of effective therapies. Actual management consists of lifestyle modification, vitamin supplements, and supportive measures in the advanced stages...
2015: Clinical Ophthalmology
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