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https://www.readbyqxmd.com/read/28537917/microrna-210-suppresses-glucocorticoid-receptor-expression-in-response-to-hypoxia-in-fetal-rat-cardiomyocytes
#1
Shannalee R Martinez, Qingyi Ma, Chiranjib Dasgupta, Xianmei Meng, Lubo Zhang
Hypoxia is a common intrauterine stressor, often resulting in intrauterine growth restriction and increased risk for cardiovascular disease later in life. The aim of this work was to test the hypothesis that microRNA-210 (miR-210) mediates the detrimental suppression of glucocorticoid receptor (GR) in response to hypoxia in fetal rat cardiomyocytes. Cardiomyocytes isolated from gestational day 21 Sprague Dawley fetal rats showed increased miR-210 levels and reduced GR abundance after exposure to ex vivo hypoxia (1% O2)...
May 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535453/inhibition-of-neddylation-modification-sensitizes-pancreatic-cancer-cells-to-gemcitabine
#2
Hua Li, Weihua Zhou, Lihui Li, Jianfu Wu, Xiaoli Liu, Lili Zhao, Lijun Jia, Yi Sun
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the USA with a 5-year survival rate less than 3% to 5%. Gemcitabine remains as a standard care for PDAC patients. Although protein neddylation is abnormally activated in many human cancers, whether neddylation dysregulation is involved in PDAC and whether targeting neddylation would sensitize pancreatic cancer cells to gemcitabine remain elusive. Here we report that high expression of neddylation components, NEDD8 and NAE1, are associated with poor survival of PDAC patients...
May 20, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28535437/comparative-evaluation-of-three-fda-approved-hiv-ag-ab-combination-tests-using-a-genetically-diverse-hiv-panel-and-diagnostic-specimens
#3
Xiaoxing Qiu, Lori Sokoll, Paul Yip, Debra J Elliott, Renu Dua, Phaedre Mohr, Xiao Yan Wang, Megan Spencer, Priscilla Swanson, George J Dawson, John Hackett
BACKGROUND: HIV Ag/Ab combination assays are recommended by CDC for routine screening and several HIV Ag/Ab combination tests are now FDA-approved. Maintaining high specificity and consistent sensitivity across diverse HIV strains is critical for these assays to accurately detect HIV infection and expedite delivery of patient results. OBJECTIVES: To evaluate performance of three FDA-approved HIV tests: ARCHITECT HIV Combo (Abbott), ADVIA Centaur HIV Combo (Siemens) and BioPlex HIV Ag-Ab (Bio-Rad)...
May 13, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28535374/discovery-of-stromal-regulatory-networks-that-suppress-ras-sensitized-epithelial-cell-proliferation
#4
Huayang Liu, James A Dowdle, Safiya Khurshid, Nicholas J Sullivan, Nicholas Bertos, Komal Rambani, Markus Mair, Piotr Daniel, Esther Wheeler, Xing Tang, Kyle Toth, Michael Lause, Markus E Harrigan, Karl Eiring, Connor Sullivan, Matthew J Sullivan, Serena W Chang, Siddhant Srivastava, Joseph S Conway, Raleigh Kladney, Joseph McElroy, Sooin Bae, Yuanzhi Lu, Ali Tofigh, Sadiq M I Saleh, Soledad A Fernandez, Jeffrey D Parvin, Vincenzo Coppola, Erin R Macrae, Sarmila Majumder, Charles L Shapiro, Lisa D Yee, Bhuvaneswari Ramaswamy, Michael Hallett, Michael C Ostrowski, Morag Park, Helen M Chamberlin, Gustavo Leone
Mesodermal cells signal to neighboring epithelial cells to modulate their proliferation in both normal and disease states. We adapted a Caenorhabditis elegans organogenesis model to enable a genome-wide mesodermal-specific RNAi screen and discovered 39 factors in mesodermal cells that suppress the proliferation of adjacent Ras pathway-sensitized epithelial cells. These candidates encode components of protein complexes and signaling pathways that converge on the control of chromatin dynamics, cytoplasmic polyadenylation, and translation...
May 22, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28535272/measures-of-financial-capacity-a-review
#5
Angela R Ghesquiere, Caitlin McAfee, Jason Burnett
Purpose of the Study: Capacity to manage finances and make financial decisions can affect risk for financial exploitation and is often the basis for legal determinations of conservatorship/guardianship. Several structured assessments of financial capacity have been developed, but have not been compared regarding their focus, validity, or reliability. Therefore, we conducted a review of financial capacity measures to examine these factors. Design and Methods: We searched electronic databases, reference lists in identified articles, conference proceedings and other grey literature for measures of financial capacity...
May 23, 2017: Gerontologist
https://www.readbyqxmd.com/read/28535046/inhibitory-effect-of-piceatannol-on-tnf-%C3%AE-mediated-inflammation-and-insulin-resistance-in-3t3-l1-adipocytes
#6
Yanfang Li, Puyu Yang, Qimeng Chang, Jing Wang, Jie Liu, Yuan Lv, Thomas T Y Wang, Boyan Gao, Yaqiong Zhang, Liangli Lucy Yu
Piceatannol, a bioactive component in grapes and blueberry, was examined for its potential in decreasing the inflammatory activities in adipocytes using a co-cultured adipocytes and macrophages system, and suppressing TNF-α mediated inflammation and the related insulin resistance using a 3T3-L1 adipocytes model. Piceatannol treatment significantly reduced the release of inflammatory cytokines of TNF-α and MCP-1 in the co-cultured system and inhibited TNF-α induced expression of IL-6 and MCP-1 at both mRNA and protein levels in the 3T3-L1 adipocytes...
May 23, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28534543/-evolution-of-patient-safety-culture-in-a-medium-stay-hospital-monitoring-indicators
#7
M J Merino-Plaza, F J Carrera-Hueso, M Castillo-Blasco, A Martínez-Asensi, R Martínez-Capella, N Fikri-Benbrahim
BACKGROUND: Patient safety is a challenge for health care. The aim of this study is to identify the dimensions with the greatest impact on patient safety culture of healthcare staff in a medium-stay hospital; to asses its evolution over time and to check the sensitivity of monitoring indicators. METHODS: Two cross-sectional studies (2013 to 2015) were conducted. The safety culture assessment tool used was the Spanish version of the "Hospital Survey on Patient Safety" (AHRQ)...
April 30, 2017: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28534517/prolonged-exposure-to-extracellular-lumican-restrains-pancreatic-adenocarcinoma-growth
#8
X Li, Y Kang, D Roife, Y Lee, M Pratt, M R Perez, B Dai, E J Koay, J B Fleming
We previously demonstrated that pancreatic stellate cells within pancreatic ductal adenocarcinoma (PDAC) stroma secrete lumican and its presence is associated with prolonged survival of patients with localized PDAC. Here, we observed that extracellular lumican decreases PDAC tumour cell growth in xenograft and syngeneic orthotopic animal models, and induces growth inhibition of low-passage human PDAC cells in a species-specific manner. PDAC cells grown in variant culture conditions and exposed to extracellular lumican display typical characterizations of cancer cell in a quiescent state, such as growth inhibition, apoptosis, G0/G1 arrest and chemoresistance...
May 22, 2017: Oncogene
https://www.readbyqxmd.com/read/28534337/-mir-145-inhibits-drug-resistance-to-oxaliplatin-in-colorectal-cancer-cells-through-regulating-g-protein-coupled-receptor-98
#9
Qiang Fu, Jing Cheng, Jindai Zhang, Yonglei Zhang, Xiaobing Chen, Jianguo Xie, Suxia Luo
OBJECTIVE: To predict and identify the target gene of miR-145, and to explore the underlying mechanism of the inhibition of miR-145 on drug resistance to Oxaliplatin (L-OHP) in human colorectal cancer cells. METHODS: L-OHP-resistant human colorectal cancer cell line (HCT116/L-OHP) was established in vitro by exposing to increased concentrations of L-OHP in cell culture medium. MiR-145-mimics and its negative control (NC-miRNA) were transfected into HCT116/L-OHP cells using liposome to establish HCT116/L-OHP(mimics) over-expressing miR-145 and HCT116/L-OHP(NC)...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28534013/serum-from-pregnant-women-with-gestational-diabetes-mellitus-increases-the-expression-of-fabp4-mrna-in-primary-subcutaneous-human-pre-adipocytes
#10
Lan Li, Se Jin Lee, Song Yi Kook, Tae Gyu Ahn, Ji Yeon Lee, Jong Yun Hwang
OBJECTIVE: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first detected during pregnancy. It can result in pregnancy complications such as birth injury, stillbirth. Fatty acid-binding protein 4 (FABP4), found in adipose tissue, is associated with insulin resistance, and type 2 diabetes. The aim of this study was to investigate whether FABP4 in the placenta and decidua of pregnant women with GDM is higher than that in normal pregnant women, and whether serum from pregnant women with GDM may cause adipocytes to secrete more FABP4 than does serum from a normal pregnant group...
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28533948/radiosensitization-effect-of-hsa-mir-138-2-3p-on-human-laryngeal-cancer-stem-cells
#11
Ying Zhu, Li-Yun Shi, Yan-Min Lei, Yan-Hong Bao, Zhao-Yang Li, Fei Ding, Gui-Ting Zhu, Qing-Qing Wang, Chang-Xin Huang
BACKGROUND: Treatments that target cancer stem cells play an important role in the controlling and eliminating of tumor initiation as well as in development, progression, and chemotherapy/radiotherapy resistance. In our previous study, we cultured and harvested human laryngeal cancer stem cells (CSCs) and applied microRNA biochips to screen differentially expressed miRNAs that were related to radiation tolerance in irradiated human laryngeal CSCs. According to the predicted genes and pathways of differential miRNAs target, down-regulated expression of hsa-miR-138-2-3p under radiation was thought to play a key role in enhancing the radio-sensitivity in human laryngeal squamous cancer stem cells...
2017: PeerJ
https://www.readbyqxmd.com/read/28533857/antibiogram-profile-of-uropathogens-isolated-at-bahir-dar-regional-health-research-laboratory-centre-northwest-ethiopia
#12
Awoke Derbie, Derese Hailu, Daniel Mekonnen, Bayeh Abera, Gashaw Yitayew
INTRODUCTION: Antimicrobial resistance among bacteria that cause urinary tract infection (UTI) has been increasing since the introduction of chemotherapy. This study was aimed to assess the types of isolates from patients with UTI and to determine their current antimicrobial susceptibility profile. METHODS: A record based retrospective analysis of bacterial uropathogens processed in the period of January 2012 to December 2014 at Bahir Dar Health Research Laboratory Center (BRHRLC) was determined...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28533127/primary-human-polarized-small-intestinal-epithelial-barriers-respond-differently-to-a-hazardous-and-an-innocuous-protein
#13
A D Eaton, C Zimmermann, B Delaney, B P Hurley
An experimental platform employing human derived intestinal epithelial cell (IEC) line monolayers grown on permeable Transwell(®) filters was previously investigated to differentiate between hazardous and innocuous proteins. This approach was effective at distinguishing these types of proteins and perturbation of monolayer integrity, particularly transepithelial electrical resistance (TEER), was the most sensitive indicator. In the current report, in vitro indicators of monolayer integrity, cytotoxicity, and inflammation were evaluated using primary (non-transformed) human polarized small intestinal epithelial barriers cultured on Transwell(®) filters to compare effects of a hazardous protein (Clostridium difficile Toxin A [ToxA]) and an innocuous protein (bovine serum albumin [BSA])...
May 19, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28533091/na-h-exchange-regulatory-factor-1-is-required-for-romk1-k-channel-expression-in-the-surface-membrane-of-cultured-m-1-cortical-collecting-duct-cells
#14
Takashi Suzuki, Kazuyoshi Nakamura, Taira Mayanagi, Kenji Sobue, Manabu Kubokawa
The ROMK1 K(+) channel, a member of the ROMK channel family, is the major candidate for the K(+) secretion pathway in the renal cortical collecting duct (CCD). ROMK1 possesses a PDZ domain-binding motif at its C-terminus that is considered a modulator of ROMK1 expression via interaction with Na(+)/H(+) exchange regulatory factor (NHERF) 1 and NHERF2 scaffold protein. Although NHERF1 is a potential binding partner of the ROMK1 K(+) channel, the interaction between NHERF1 and K(+) channel activity remains unclear...
May 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28532554/traditional-medicines-and-kidney-disease-in-low-and-middle-income-countries-opportunities-and-challenges
#15
REVIEW
John W Stanifer, Kajiru Kilonzo, Daphne Wang, Guobin Su, Wei Mao, Lei Zhang, La Zhang, Shobhana Nayak-Rao, J Jaime Miranda
Traditional medicines are a principal form of health care for many populations, particularly in low- and middle-income countries, and they have gained attention as an important means of health care coverage globally. In the context of kidney diseases, the challenges and opportunities presented by traditional medicine practices are among the most important considerations for developing effective and sustainable public health strategies. However, little is known about the practices of traditional medicines in relation to kidney diseases, especially concerning benefits and harms...
May 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28532445/cross-cultural-adaptation-and-validation-of-the-spanish-version-of-the-oxford-hip-score-in-patients-with-hip-osteoarthritis
#16
Jesús Martín-Fernández, Pedro Gray-Laymón, Antonio Molina-Siguero, Javier Martínez-Martín, Roberto García-Maroto, Isidoro García-Sánchez, Lidia García-Pérez, Vanesa Ramos-García, Olga Castro-Casas, Amaia Bilbao
BACKGROUND: Osteoarthritis (OA) of the hip is a disease that entails a major burden for patients and the society as a whole. One way of measuring this burden for the patient is through impact on Health-related Quality of Life (HRQL). The Oxford Hip Score (OHS) is a well-known tool to measure HRQL in patients with OA of the hip. This study aims to assess the psychometric properties of the Spanish-adapted version of the OHS, including its reliability, validity, and sensitivity to change...
May 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28532442/an-integrated-enhancement-and-reconstruction-strategy-for-the-quantitative-extraction-of-actin-stress-fibers-from-fluorescence-micrographs
#17
Zhen Zhang, Shumin Xia, Pakorn Kanchanawong
BACKGROUND: The stress fibers are prominent organization of actin filaments that perform important functions in cellular processes such as migration, polarization, and traction force generation, and whose collective organization reflects the physiological and mechanical activities of the cells. Easily visualized by fluorescence microscopy, the stress fibers are widely used as qualitative descriptors of cell phenotypes. However, due to the complexity of the stress fibers and the presence of other actin-containing cellular features, images of stress fibers are relatively challenging to quantitatively analyze using previously developed approaches, requiring significant user intervention...
May 22, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28532188/differential-amplification-of-marek-s-disease-cvi988-vaccine-and-of-wild-type-isolates-from-organs-of-commercial-chickens-using-single-or-duplexed-probes-in-real-time-pcr
#18
Irit Davidson, Amira Natour-Altoury, Israel Raibstein, Yaad Dahan
The DIVA test, based on the MDV pp38 gene was described by Baigent et al. (2016), using similar primers and alternate probes for virulent MDV-1 and the vaccine CVI988 virus. We now explored the assay applicability for commercial vaccines and for DNAs of commercial chickens, as former study employed tissue cultured prototype MDV strains and chicken tissue from experimental infection trials. DNA of chicken visceral organs and feathers of either vaccinated, or naturally-infected with virulent MDV-1 wild-type viruses was used for DIVA-PCR real-time PCR...
May 22, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28531132/effects-of-%C3%AE-carotene-and-its-cleavage-products-in-primary-pneumocyte-type-ii-cells
#19
Cornelia Haider, Franziska Ferk, Ekramije Bojaxhi, Giuseppe Martano, Hanno Stutz, Nikolaus Bresgen, Siegfried Knasmüller, Avdulla Alija, Peter M Eckl
β-Carotene has been shown to increase the risk of developing lung cancer in smokers and asbestos workers in two large scale trails, the Beta-Carotene and Retinol Efficacy Trial (CARET) and the Alpha-Tocopherol Beta-carotene Cancer Prevention Trial (ATBC). Based on this observation, it was proposed that genotoxic oxidative breakdown products may cause this effect. In support of this assumption, increased levels of sister chromatid exchanges, micronuclei, and chromosomal aberrations were found in primary hepatocyte cultures treated with a mixture of cleavage products (CPs) and the major product apo-8'carotenal...
May 21, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28530705/ccn5-wisp-2-restores-er-%C3%A2-in-normal-and-neoplastic-breast-cells-and-sensitizes-triple-negative-breast-cancer-cells-to-tamoxifen
#20
S Sarkar, A Ghosh, S Banerjee, G Maity, A Das, M A Larson, V Gupta, I Haque, O Tawfik, S K Banerjee
CCN5/WISP-2 is an anti-invasive molecule and prevents breast cancer (BC) progression. However, it is not well understood how CCN5 prevents invasive phenotypes of BC cells. CCN5 protein expression is detected in estrogen receptor-α (ER-α) -positive normal breast epithelial cells as well as BC cells, which are weakly invasive and rarely metastasize depending on the functional status of ER-α. A unique molecular relation between CCN5 and ER-α has been established as the components of the same signaling pathway that coordinate some essential signals associated with the proliferation as well as delaying the disease progression from a non-invasive to invasive phenotypes...
May 22, 2017: Oncogenesis
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