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https://www.readbyqxmd.com/read/29191247/the-implication-of-the-shortage-of-health-workforce-specialist-on-universal-health-coverage-in-kenya
#1
Mumbo Hazel Miseda, Samuel Odhiambo Were, Cirindi Anne Murianki, Milo Peter Mutuku, Stephen N Mutwiwa
BACKGROUND: Globally, there is an acute shortage of human resources for health (HRH), and the greatest burden is borne by low-income countries especially in sub-Saharan Africa and some parts of Asia. This shortage has not only considerably constrained the achievement of health-related development goals but also impeded accelerated progress towards universal health coverage (UHC). Like any other low-income country, Kenya is experiencing health workforce shortage particularly in specialized healthcare workers to cater for the rapidly growing need for specialized health care (MOH Training Needs Assessment report (2015))...
December 1, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28873391/high-prevalence-of-thiamine-vitamin-b1-deficiency-in-early-childhood-among-a-nationally-representative-sample-of-cambodian-women-of-childbearing-age-and-their-children
#2
Kyly C Whitfield, Geoffry Smith, Chhoun Chamnan, Crystal D Karakochuk, Prak Sophonneary, Khov Kuong, Marjoleine Amma Dijkhuizen, Rathavuth Hong, Jacques Berger, Tim J Green, Frank Tammo Wieringa
BACKGROUND: Thiamine deficiency is thought to be an issue in Cambodia and throughout Southeast Asia due to frequent clinical reports of infantile beriberi. However the extent of this public health issue is currently unknown due to a lack of population-representative data. Therefore we assessed the thiamine status (measured as erythrocyte thiamine diphosphate concentrations; eThDP) among a representative sample of Cambodian women of childbearing age (15-49 y) and their young children (6-69 mo)...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28768736/congenital-diaphragmatic-hernias-from-genes-to-mechanisms-to-therapies
#3
REVIEW
Gabrielle Kardon, Kate G Ackerman, David J McCulley, Yufeng Shen, Julia Wynn, Linshan Shang, Eric Bogenschutz, Xin Sun, Wendy K Chung
Congenital diaphragmatic hernias (CDHs) and structural anomalies of the diaphragm are a common class of congenital birth defects that are associated with significant morbidity and mortality due to associated pulmonary hypoplasia, pulmonary hypertension and heart failure. In ∼30% of CDH patients, genomic analyses have identified a range of genetic defects, including chromosomal anomalies, copy number variants and sequence variants. The affected genes identified in CDH patients include transcription factors, such as GATA4, ZFPM2, NR2F2 and WT1, and signaling pathway components, including members of the retinoic acid pathway...
August 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28422868/meta-analysis-of-possible-role-of-cadherin-gene-methylation-in-evolution-and-prognosis-of-hepatocellular-carcinoma-with-a-prisma-guideline
#4
Chunxiao Zhu, Xuefeng Feng, Guoliang Ye, Tao Huang
BACKGROUND: Cadherins (CDHs) have been reported to be associated with cancer. However, the clinical significance of CDH gene methylation in hepatocellular carcinoma (HCC) remains unclear. METHODS: Based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria, available studies were identified from online electronic database. The overall odds ratio (OR) and the corresponding 95% confidence interval (95% CI) were calculated and analyzed...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28392805/cadherins-associate-with-distinct-stem-cell-related-transcription-factors-to-coordinate-the-maintenance-of-stemness-in-triple-negative-breast-cancer
#5
Chuanwei Yang, Xuemei Zhao, Naipeng Cui, Yulong Liang
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer with poor prognosis and is enriched in cancer stem cells (CSCs). However, it is not completely understood how the CSCs were maintained in TNBC. In this study, by analyzing The Cancer Genome Atlas (TCGA) provisional datasets and several small-size breast datasets, we found that cadherins (CDHs) 2, 4, 6, and 17 were frequently amplified/overexpressed in 47% of TNBC while E-cadherin (CDH1) was downregulated/mutated at 10%. The alterations of CDH2/4/6/17 were strongly associated with the elevated levels of several stem cell-related transcription factors (SC-TFs) including FOXM1, MCM2, WWTR1, SNAI1, and SOX9...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28291519/structural-studies-of-neurospora-crassa-lpmo9d-and-redox-partner-cdhiia-using-neutron-crystallography-and-small-angle-scattering
#6
Annette M Bodenheimer, William B O'Dell, Christopher B Stanley, Flora Meilleur
Sensitivity to hydrogen/deuterium and lack of observable radiation damage makes cold neutrons an ideal probe the structural studies of proteins with highly photosensitive groups such as the copper center of lytic polysaccharide monooxygenases (LPMOs) and flavin adenine dinucleotide (FAD) and heme redox cofactors of cellobiose dehydrogenases (CDHs). Here, neutron crystallography and small-angle neutron scattering are used to investigate Neurospora crassa LPMO9D (NcLPMO9D) and CDHIIA (NcCDHIIA), respectively...
March 4, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28051089/cadherin-26-is-an-alpha-integrin-binding-epithelial-receptor-regulated-during-allergic-inflammation
#7
J M Caldwell, M H Collins, K A Kemme, J D Sherrill, T Wen, M Rochman, E M Stucke, L Amin, H Tai, P E Putnam, M J Jiménez-Dalmaroni, M R Wormald, A Porollo, J P Abonia, M E Rothenberg
Cadherins (CDH) mediate diverse processes critical in inflammation, including cell adhesion, migration, and differentiation. Herein, we report that the uncharacterized cadherin 26 (CDH26) is highly expressed by epithelial cells in human allergic gastrointestinal tissue. In vitro, CDH26 promotes calcium-dependent cellular adhesion of cells lacking endogenous CDHs by a mechanism involving homotypic binding and interaction with catenin family members (alpha, beta, and p120), as assessed by biochemical assays. Additionally, CDH26 enhances cellular adhesion to recombinant integrin α4β7 in vitro; conversely, recombinant CDH26 binds αE and α4 integrins in biochemical and cellular functional assays, respectively...
September 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/27836848/inactivation-of-cellobiose-dehydrogenases-modifies-the-cellulose-degradation-mechanism-of-podospora-anserina
#8
Narumon Tangthirasunun, David Navarro, Sona Garajova, Didier Chevret, Laetitia Chan Ho Tong, Valérie Gautier, Kevin D Hyde, Philippe Silar, Jean-Guy Berrin
Conversion of biomass into high-value products, including biofuels, is of great interest to developing sustainable biorefineries. Fungi are an inexhaustible source of enzymes to degrade plant biomass. Cellobiose dehydrogenases (CDHs) play an important role in the breakdown through synergistic action with fungal lytic polysaccharide monooxygenases (LPMOs). The three CDH genes of the model fungus Podospora anserina were inactivated, resulting in single and multiple CDH mutants. We detected almost no difference in growth and fertility of the mutants on various lignocellulose sources, except on crystalline cellulose, on which a 2-fold decrease in fertility of the mutants lacking P...
January 15, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27643617/activation-of-bacterial-lytic-polysaccharide-monooxygenases-with-cellobiose-dehydrogenase
#9
Jennifer S M Loose, Zarah Forsberg, Daniel Kracher, Stefan Scheiblbrandner, Roland Ludwig, Vincent G H Eijsink, Gustav Vaaje-Kolstad
Lytic polysaccharide monooxygenases (LPMOs) represent a recent addition to the carbohydrate-active enzymes and are classified as auxiliary activity (AA) families 9, 10, 11, and 13. LPMOs are crucial for effective degradation of recalcitrant polysaccharides like cellulose or chitin. These enzymes are copper-dependent and utilize a redox mechanism to cleave glycosidic bonds that is dependent on molecular oxygen and an external electron donor. The electrons can be provided by various sources, such as chemical compounds (e...
December 2016: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/27515896/traumatic-dental-injuries-and-socioeconomic-position-findings-from-the-children-s-dental-health-survey-2013
#10
Alex Blokland, Richard G Watt, Georgios Tsakos, Anja Heilmann
OBJECTIVES: The aim of this study was to assess whether traumatic dental injuries (TDI) were socially graded among children and adolescents in England, Wales and Northern Ireland, using nationally representative data from the Children's Dental Health Survey (CDHS) 2013. METHODS: This cross-sectional study used data from the Children's Dental Health Survey 2013 which was conducted among a nationally representative sample of schoolchildren in England, Wales and Northern Ireland...
August 12, 2016: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/27338454/the-high-prevalence-of-anemia-in-cambodian-children-and-women-cannot-be-satisfactorily-explained-by-nutritional-deficiencies-or-hemoglobin-disorders
#11
Frank Tammo Wieringa, Miriam Dahl, Chhoun Chamnan, Etienne Poirot, Khov Kuong, Prak Sophonneary, Muth Sinuon, Valerie Greuffeille, Rathavuth Hong, Jacques Berger, Marjoleine Amma Dijkhuizen, Arnaud Laillou
BACKGROUND: Anemia is highly prevalent in Cambodian women and children, but data on causes of anemia are scarce. We performed a national micronutrient survey in children and women that was linked to the Cambodian Demographic Health Survey 2014 (CDHS-2014) to assess the prevalence of micronutrient deficiency, hemoglobin disorders and intestinal parasite infection. METHODS: One-sixth of households from the CDHS-2014 were selected for a follow-up visit for the micronutrient survey...
June 7, 2016: Nutrients
https://www.readbyqxmd.com/read/27312718/single-domain-flavoenzymes-trigger-lytic-polysaccharide-monooxygenases-for-oxidative-degradation-of-cellulose
#12
Sona Garajova, Yann Mathieu, Maria Rosa Beccia, Chloé Bennati-Granier, Frédéric Biaso, Mathieu Fanuel, David Ropartz, Bruno Guigliarelli, Eric Record, Hélène Rogniaux, Bernard Henrissat, Jean-Guy Berrin
The enzymatic conversion of plant biomass has been recently revolutionized by the discovery of lytic polysaccharide monooxygenases (LPMOs) that carry out oxidative cleavage of polysaccharides. These very powerful enzymes are abundant in fungal saprotrophs. LPMOs require activation by electrons that can be provided by cellobiose dehydrogenases (CDHs), but as some fungi lack CDH-encoding genes, other recycling enzymes must exist. We investigated the ability of AA3_2 flavoenzymes secreted under lignocellulolytic conditions to trigger oxidative cellulose degradation by AA9 LPMOs...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27277071/the-clinical-results-of-a-novel-method-for-minimal-invasive-dynamic-hip-screw-fixation-of-intertrochanteric-fractures-compared-to-the-conventional-one
#13
N Acar, A Harb, A Albaya, H Kaskin
PURPOSE: Hip intertrochanteric fractures are very frequent. Early mobilization reduces the associated mortality and morbidity rate. DHS is still commonly used in many centers. We describe a new minimal invasive DHS technique (MIDHS) depending on radiological land marks, facilitating the application of DHS in a proper way without the use of an angle guide and we retrospectively compared the functional results of the new technique with that of the conventional DHS (CDHS) technique. METHODS: 116 patients (MIDHS n = 56; CDHS n = 60) with stable intertrochanteric fractures were followed up for at least 12 months...
June 8, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/26748369/a-novel-bio-electronic-tongue-using-different-cellobiose-dehydrogenases-to-resolve-mixtures-of-various-sugars-and-interfering-analytes
#14
Andrea Cipri, Christopher Schulz, Roland Ludwig, Lo Gorton, Manel Del Valle
A novel application of cellobiose dehydrogenase (CDH) as sensing element for a Bioelectronic Tongue (BioET) system has been tested. In this work CDHs from various fungi, which exhibit different substrate specificities, were used to discriminate between lactose and glucose in presence of the interfering matrix compound Ca(2+) in various mixtures. This work exploits the advantage of an electronic tongue system with practically zero pre-treatment of samples and operation at low voltages in a direct electron transfer mode...
May 15, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/26672182/-cervical-disc-herniation-diagnosis-and-treatment
#15
M-V Corniola, E Tessitore, K Schaller, O P Gautschi
A cervical disc herniation (CDH) is a frequently encountered pathology in primary care medicine. It may give rise to a compression of a nerve root (a radiculopathy, with or without sensory-motor deficit) or of the spinal cord (myelopathy). The majority of CDHs can be supported by means of a conservative treatment. When a radiculopathy is found and a clinico-radiological correlation is present, a moderate neurological deficit appears suddenly, or if it is progressive under conservative treatment or if pain is poorly controlled by well-conducted conservative treatment performed during 6 to 8 months, surgery is then recommended...
October 28, 2015: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26635257/trends-in-caries-experience-and-associated-contextual-factors-among-indigenous-children
#16
Diep Hong Ha, Ratilal Lalloo, Lisa M Jamieson, Loc Giang Do
OBJECTIVE: To assess dental caries trends in indigenous children in South Australia, 2001-2010; and contribution by area-level socioeconomic status (SES), remoteness and water fluoridation status. METHODS: This study is a part of the Child Dental Health Survey (CDHS) is an ongoing national surveillance survey in Australia including children enrolled in the School Dental Services (SDS). Postcode-level adjusted mean deciduous and permanent caries experience was estimated at each year...
June 2016: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/25913436/inter-domain-electron-transfer-in-cellobiose-dehydrogenase-modulation-by-ph-and-divalent-cations
#17
Daniel Kracher, Kawah Zahma, Christopher Schulz, Christoph Sygmund, Lo Gorton, Roland Ludwig
The flavocytochrome cellobiose dehydrogenase (CDH) is secreted by wood-decomposing fungi, and is the only known extracellular enzyme with the characteristics of an electron transfer protein. Its proposed function is reduction of lytic polysaccharide mono-oxygenase for subsequent cellulose depolymerization. Electrons are transferred from FADH2 in the catalytic flavodehydrogenase domain of CDH to haem b in a mobile cytochrome domain, which acts as a mediator and transfers electrons towards the active site of lytic polysaccharide mono-oxygenase to activate oxygen...
August 2015: FEBS Journal
https://www.readbyqxmd.com/read/25807280/muscle-connective-tissue-controls-development-of-the-diaphragm-and-is-a-source-of-congenital-diaphragmatic-hernias
#18
Allyson J Merrell, Benjamin J Ellis, Zachary D Fox, Jennifer A Lawson, Jeffrey A Weiss, Gabrielle Kardon
The diaphragm is an essential mammalian skeletal muscle, and defects in diaphragm development are the cause of congenital diaphragmatic hernias (CDHs), a common and often lethal birth defect. The diaphragm is derived from multiple embryonic sources, but how these give rise to the diaphragm is unknown, and, despite the identification of many CDH-associated genes, the etiology of CDH is incompletely understood. Using mouse genetics, we show that the pleuroperitoneal folds (PPFs), which are transient embryonic structures, are the source of the diaphragm's muscle connective tissue and regulate muscle development, and we show that the striking migration of PPF cells controls diaphragm morphogenesis...
May 2015: Nature Genetics
https://www.readbyqxmd.com/read/25327814/does-fluoride-in-the-water-close-the-dental-caries-gap-between-indigenous-and-non-indigenous-children
#19
COMPARATIVE STUDY
R Lalloo, L M Jamieson, D Ha, A Ellershaw, L Luzzi
BACKGROUND: Indigenous children experience significantly more dental caries than non-Indigenous children. This study assessed if access to fluoride in the water closed the gap in dental caries between Indigenous and non-Indigenous children. METHODS: Data from four states and two territories were sourced from the Child Dental Health Survey (CDHS) conducted in 2010. The outcomes were dental caries in the deciduous and permanent dentitions, and the explanatory variables were Indigenous status and access to fluoridated water (≥0...
September 2015: Australian Dental Journal
https://www.readbyqxmd.com/read/25035251/-minimally-invasive-dynamic-hip-screw-technique-shorter-surgical-time-with-similar-post-surgical-results-compared-to-conventional-dhs-technique-a-retrospective-cohort-study
#20
A Méndez-Gil, J Á Fernández-Valencia Laborde, J M Estrada-Masllorens, R Plaza-García, M Ríos Martín, P Camacho Carrasco, S Prat Fabregat, J Riba Ferret
AIM: The treatment of intertrochanteric fractures using a minimally invasive dynamic hip screw (MIDHS) technique has been reported to provide better results than the conventional technique (CDHS). The present study aims to determine whether there are any differences in terms of transfusion needs, morbidity, length of hospital stay, and economical costs, based on a study of two retrospective cohorts. MATERIAL AND METHOD: Cohorts study of 80 patients with intertrochanteric femoral fractures (31-A1 and 31-A2...
November 2014: Revista Española de Cirugía Ortopédica y Traumatología
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