J M Caldwell, M H Collins, K A Kemme, J D Sherrill, T Wen, M Rochman, E M Stucke, L Amin, H Tai, P E Putnam, M J Jiménez-Dalmaroni, M R Wormald, A Porollo, J P Abonia, M E Rothenberg
Cadherins (CDH) mediate diverse processes critical in inflammation, including cell adhesion, migration, and differentiation. Herein, we report that the uncharacterized cadherin 26 (CDH26) is highly expressed by epithelial cells in human allergic gastrointestinal tissue. In vitro, CDH26 promotes calcium-dependent cellular adhesion of cells lacking endogenous CDHs by a mechanism involving homotypic binding and interaction with catenin family members (alpha, beta, and p120), as assessed by biochemical assays. Additionally, CDH26 enhances cellular adhesion to recombinant integrin α4β7 in vitro; conversely, recombinant CDH26 binds αE and α4 integrins in biochemical and cellular functional assays, respectively...
September 2017: Mucosal Immunology