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https://www.readbyqxmd.com/read/28731494/subthreshold-micropulse-laser-reduces-anti-vegf-injection-burden-in-patients-with-diabetic-macular-edema
#1
Elad Moisseiev, Sam Abbassi, Sumeer Thinda, Joseph Yoon, Glenn Yiu, Lawrence S Morse
PURPOSE: To evaluate the efficacy of micropulse laser in the early treatment of diabetic macular edema (DME) and its associated burden of anti-vascular endothelial growth factor (VEGF) injections. METHODS: This retrospective comparative study compared a group of 19 eyes with DME treated with micropulse laser to a matched control group of 19 eyes with DME treated with ranibizumab injections without micropulse laser. Recorded parameters included previous medical and ocular history, previous and subsequent ranibizumab injections administered for DME, visual acuity (VA), central macular thickness throughout the follow-up period, and the occurrence of any complications...
July 20, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28730084/analyzing-cytokines-as-biomarkers-to-evaluate-severity-of-glaucoma
#2
Yao Tong, Ya-Li Zhou, Yan Zheng, Manas Biswal, Pei-Quan Zhao, Zhao-Yang Wang
AIM: To analyze cytokines as biomarkers for evaluation of severity of glaucoma. METHODS: This was a prospective case-control study including 29 eyes with glaucoma. Besides, 28 eyes with senile cataract were used as control. Patients were classified into four groups: acute angle closure glaucoma (AACG), chronic angle closure glaucoma (CACG), primary open angle glaucoma (POAG) and senile cataract. Undiluted vitreous samples were collected, then vitreous concentrations of 9 types of cytokines were determined by cytometric bead assay system: γ-interferon (IFNg), interleukin (IL)-10, IL-2, IL-4, IL-5, interferon-γ-inducible protein (IP)-10, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28715845/apatinib-an-inhibitor-of-vascular-endothelial-growth-factor-receptor-2-suppresses-pathologic-ocular-neovascularization-in-mice
#3
Koung Li Kim, Wonhee Suh
Purpose: Vascular endothelial growth factor (VEGF) signaling via VEGF receptor 2 (VEGFR2) plays a crucial role in pathologic ocular neovascularization. In this study, we investigated the antiangiogenic effect of apatinib, a pharmacologic inhibitor of VEGFR2 tyrosine kinase, against oxygen-induced retinopathy (OIR) and laser-induced choroidal neovascularization (CNV) in mice. Methods: Western blotting and in vitro angiogenesis assays were performed using human retinal microvascular endothelial cells (HRMECs)...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28709426/xue-fu-zhu-yu-decoction-protects-rats-against-retinal-ischemia-by-downregulation-of-hif-1%C3%AE-and-vegf-via-inhibition-of-rbp2-and-pkm2
#4
Shu-Qiu Tan, Xue Geng, Jorn-Hon Liu, Wynn Hwai-Tzong Pan, Li-Xiang Wang, Hui-Kang Liu, Lei Hu, Hsiao-Ming Chao
BACKGROUND: Retinal ischemia-related eye diseases result in visual dysfunction. This study investigates the protective effects and mechanisms of Xue-Fu-Zhu-Yu decoction (XFZYD) with respect to retinal ischemia. METHODS: Retinal ischemia (I) was induced in Wistar rats by a high intraocular pressure (HIOP) of 120 mmHg for 1 h, which was followed by reperfusion of the ischemic eye; the fellow untreated eye acted as a control. Electroretinogram (ERG), biochemistry and histopathology investigations were performed...
July 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28699928/anti-vegf-therapy-versus-photodynamic-therapy-in-the-treatment-of-choroidal-neovascularization-secondary-to-central-serous-chorioretinopathy
#5
Enrico Peiretti, Giulia Caminiti, Rita Serra, Lea Querques, Riccardo Pertile, Giuseppe Querques
PURPOSE: To evaluate the efficacy of photodynamic therapy (PDT) compared with intravitreal vascular endothelial growth factor (VEGF) inhibitors alone or combined with PDT in the treatment of choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR). METHODS: Retrospective study of a consecutive series of 34 white patients (34 eyes) with angiographic evidence of choroidal neovascularization secondary to chronic central serous chorioretinopathy, divided into two groups followed for at least 12 months: 16 were treated with full fluence PDT (PDT group) and 18 with vascular endothelial growth factor inhibitors (intravitreal [IVT] group)...
July 7, 2017: Retina
https://www.readbyqxmd.com/read/28691937/macular-atrophy-and-macular-morphology-in-aflibercept-treated-neovascular-age-related-macular-degeneration
#6
Yoshimasa Kuroda, Kenji Yamashiro, Sotaro Ooto, Hiroshi Tamura, Akio Oishi, Hideo Nakanishi, Manabu Miyata, Masayuki Hata, Ayako Takahashi, Tomotaka Wakazono, Nagahisa Yoshimura, Akitaka Tsujikawa
PURPOSE: To investigate the incidence and predictors of macular atrophy during treatment with aflibercept for neovascular age-related macular degeneration in Japanese patients. METHODS: This study included patients with treatment-naive subfoveal neovascular age-related macular degeneration treated from December 2012 through January 2015. Patients were treated with bi-monthly aflibercept injections after 3 monthly loading injections for the first year. Diagnosis of retinal pigment epithelial atrophy was made based on color fundus photography, spectral-domain optical coherence tomography, and fundus autofluorescence...
July 4, 2017: Retina
https://www.readbyqxmd.com/read/28686003/the-finnish-national-guideline-for-diagnosis-treatment-and-follow-up-of-patients-with-wet-age-related-macular-degeneration
#7
Raimo Tuuminen, Hannele Uusitalo-Järvinen, Vesa Aaltonen, Nina Hautala, Sulevi Kaipiainen, Nina Laitamäki, Marko Ollila, Jari Rantanen, Satu Välimäki, Raija Sipilä, Tanja Laukkala, Jorma Komulainen, Petri Tommila, Ilkka Immonen, Anja Tuulonen, Kai Kaarniranta
Age-related macular degeneration (AMD) is the main cause of visual impairment in developed countries. Several improvements in the visualization of posterior segment of the eye together with the introduction of intravitreal anti-VEGF treatment have revolutionized the prognosis of the wet form of AMD (wAMD). Increasing incidence of wAMD together with the limited resources of society and of the healthcare system poses challenges for the provision and development of care. In context of these current aspects, we aimed to set evidence-based medical guidelines for diagnosis, treatment and follow-up of patients with wAMD...
July 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28682418/effects-of-epoxyeicosatrienoic-acids-eets-on-retinal-macular-degeneration-in-rat-models
#8
F Mei, J-G Wang, Z-J Chen, Z-L Yuan
OBJECTIVE: Here we use a rat model to investigate the effects of epoxyeicosatrienoic acids (EETs) on retinal macular degeneration along with pathological and physiological mechanisms of the disease. MATERIALS AND METHODS: Six choroidal neovascularization (CNV) rats were created with a 532 nm laser and received intravitreal injections of EETs in both eyes. On day 1, 3, 7 and 14 after photocoagulation, the thickness and area of CNV were measured with HE staining and choroidal flat mounts...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28680263/cedilanid-inhibits-retinal-neovascularization-in-a-mouse-model-of-oxygen-induced-retinopathy
#9
Jing Shang Zhang, Jin Da Wang, Ying An, Ying Xiong, Jing Li, JostB Jonas, Liang Xu, Wei Zhang, Xiu Hua Wan
PURPOSE: This study investigated the effect of cedilanid on retinal neovascularization in a mouse model of oxygen-induced retinopathy. METHODS: Seven-day-old C57BL/6 mice were exposed to 75% ± 1% oxygen for 5 days and were then returned to room air to induce retinal neovascularization. Cedilanid (0.025-0.2 μg) was intravitreally injected into the left eye of each mouse on postnatal day 12 (P12) and P15. PBS was intravitreally injected into the right eye as a control...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28676569/vegf-a-and-neuropilin-1-nrp1-shape-axon-projections-in-the-developing-cns-via-dual-roles-in-neurons-and-blood-vessels
#10
Lynda Erskine, Urielle François, Laura Denti, Andy Joyce, Miguel Tillo, Freyja Bruce, Neil Vargesson, Christiana Ruhrberg
Visual information is relayed from the eye to the brain via retinal ganglion cell (RGC) axons. Mice lacking NRP1 or NRP1-binding VEGF-A isoforms have defective RGC axon organisation alongside brain vascular defects. It is not known whether axonal defects are caused exclusively by defective VEGF-A signalling in RGCs or are exacerbated by abnormal vascular morphology. Targeted NRP1 ablation in RGCs with a Brn3b(Cre) knock-in allele reduced axonal midline crossing at the optic chiasm and optic tract fasciculation...
July 1, 2017: Development
https://www.readbyqxmd.com/read/28669776/association-of-vascular-vs-avascular-subretinal-hyperreflective-material-with-aflibercept-response-in-age-related-macular-degeneration
#11
Yu Kawashima, Masayuki Hata, Akio Oishi, Sotaro Ooto, Kenji Yamashiro, Hiroshi Tamura, Manabu Miyata, Akihito Uji, Naoko Ueda-Arakawa, Akitaka Tsujikawa
PURPOSE: To investigate flow signal within subretinal hyperreflective material (SHRM) using optical coherence tomography angiography (OCTA) and its association with aflibercept treatment responses in treatment-naïve neovascular age-related macular degeneration (nAMD). DESIGN: Prospective consecutive interventional case series METHODS: Forty-four eyes of 44 patients with treatment-naive nAMD manifesting SHRM on OCT were studied. All patients underwent OCTA and received three monthly aflibercept injections...
June 29, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28669039/blockade-of-mmp-2-and-mmp-9-inhibits-corneal-lymphangiogenesis
#12
Hai-Tao Du, Ling-Ling Du, Xian-Ling Tang, Hong-Yan Ge, Ping Liu
PURPOSE: To investigate the roles of a selective MMP-2 and -9 inhibitor (SB-3CT) in corneal inflammatory lymphangiogenesis. METHODS: The expression of MMP-2 and -9 in the cornea after suture inplacement, treated with SB-3CT or negative control, was detected by real-time polymerase chain reaction (PCR). Inflammatory corneal neovascularization (NV) was induced by corneal suture placement. Mice were treated with SB-3CT eye drops (twice daily for 1 week, 5 μL per drop; 50, 100, or 200 μM)...
July 1, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28667483/is-ellipsoid-zone-integrity-essential-for-visual-recovery-in-myopic-neovascularization-after-anti-vegf-therapy
#13
Paolo Milani, Marco Pellegrini, Amedeo Massacesi, Stefania Moschini, Marco Setaccioli, Davide Soranna, Antonella Zambon, Ferdinando Bottoni, Fulvio Bergamini
PURPOSE: To evaluate functional prognostic factors and neuroretinal changes after anti-vascular endothelial growth factor (VEGF) treatment in patients with naïve, recent myopic neovascularization (mCNV), as assessed by spectral-domain optical coherence tomography (SD-OCT). METHODS: Specific changes in tomographic features between baseline and final follow-up were retrospectively evaluated by two examiners independently. Imaging was obtained by a multi-modal imaging system which combines fluorescein angiography and SD-OCT...
June 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28666022/intravitreal-itraconazole-inhibits-laser-induced-choroidal-neovascularization-in-rats
#14
Jeong Hun Bae, Ah Reum Hwang, Chan Yun Kim, Hyeong Gon Yu, Hyoung Jun Koh, Woo Ick Yang, Hae Ran Chang, Sung Chul Lee
Choroidal neovascularization (CNV) is a major cause of severe visual loss in patients with age-related macular degeneration (AMD). Recently, itraconazole has shown potent and dose-dependent inhibition of tumor-associated angiogenesis. We evaluated the anti-angiogenic effect of itraconazole in a rat model of laser-induced CNV. After laser photocoagulation in each eye to cause CNV, right eyes were administered intravitreal injections of itraconazole; left eyes received balanced salt solution (BSS) as controls...
2017: PloS One
https://www.readbyqxmd.com/read/28658313/a-novel-in-vivo-model-of-puncture-induced-iris-neovascularization
#15
Ophélie Beaujean, Filippo Locri, Monica Aronsson, Anders Kvanta, Helder André
PURPOSE: To assess iris neovascularization by uveal puncture of the mouse eye and determine the role of angiogenic factors during iris neovascularization. METHODS: Uveal punctures were performed on BalbC mouse eyes to induce iris angiogenesis. VEGF-blockage was used as an anti-angiogenic treatment, while normoxia- and hypoxia-conditioned media from retinal pigment epithelium (RPE) cells was used as an angiogenic-inducer in this model. Iris vasculature was determined in vivo by noninvasive methods...
2017: PloS One
https://www.readbyqxmd.com/read/28655539/myopic-choroidal-neovascularization-review-guidance-and-consensus-statement-on-management
#16
Chui Ming Gemmy Cheung, Jennifer J Arnold, Frank G Holz, Kyu Hyung Park, Timothy Y Y Lai, Michael Larsen, Paul Mitchell, Kyoko Ohno-Matsui, Shih-Jen Chen, Sebastian Wolf, Tien Yin Wong
TOPIC: The aim of this article is to review and compile available information on the classification, pathophysiology, and clinical features of myopic choroidal neovascularization (CNV); to describe the latest data on the management of this disease; and to present guidance. CLINICAL RELEVANCE: In the United States, myopia affects approximately 34 million people (2010), and similar figures have been reported in Europe. Pathologic myopia (PM), a possible consequence of myopia, is estimated to affect up to 3% of the global population...
June 24, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28646440/a-comparison-of-three-different-intravitreal-treatment-modalities-of-macular-edema-due-to-branch-retinal-vein-occlusion
#17
Havva Erdogan Kaldırım, Serpil Yazgan
PURPOSE: To compare the efficacy of intravitreal injection of ranibizumab, dexamethasone implant and aflibercept for the management of macular edema (ME) related to branch retinal vein occlusion (BRVO). METHODS: This retrospective and comparative study included 62 eyes of 62 patients with BRVO and ME. Patients received one of the following treatments: 0.5 mg ranibizumab (group 1, n = 22), 0.7 mg dexamethasone implant (group 2, n = 20) and 2 mg aflibercept (group 3, n = 20)...
June 23, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28644870/effects-of-nicotine-on-corneal-wound-healing-following-acute-alkali-burn
#18
Jong Won Kim, Chae Woong Lim, Bumseok Kim
Epidemiological studies have indicated that smoking is a pivotal risk factor for the progression of several chronic diseases. Nicotine, the addictive component of cigarettes, has powerful pathophysiological properties in the body. Although the effects of cigarette smoking on corneal re-epithelialization have been studied, the effects of nicotine on corneal wound healing-related neovascularization and fibrosis have not been fully demonstrated. The aim of this study was to evaluate the effects of chronic administration of nicotine on corneal wound healing following acute insult induced by an alkali burn...
2017: PloS One
https://www.readbyqxmd.com/read/28642823/visualization-of-changes-in-the-foveal-avascular-zone-in-both-observed-and-treated-diabetic-macular-edema-using-optical-coherence-tomography-angiography
#19
Aditya Gill, Emily D Cole, Eduardo A Novais, Ricardo N Louzada, Talisa de Carlo, Jay S Duker, Nadia K Waheed, Caroline R Baumal, Andre J Witkin
BACKGROUND: Central vision loss in diabetic retinopathy is commonly related to diabetic macular edema (DME). The objective of this study was to describe changes between consecutive visits on optical coherence tomography angiography (OCTA) of the foveal avascular zone (FAZ) in eyes with DME. METHODS: 20 eyes from 14 patients with DME were imaged on 2 successive clinic visits separated by at least 1 month. The mean interval between visits was 3.2 months. The only intervention used was intravitreal anti-VEGF in 11 eyes; the others were observed over time without treatment...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28641290/long-term-follow-up-of-choroidal-neovascularization-due-to-angioid-streaks-with-pro-re-nata-intravitreal-anti-vegf-treatment
#20
Giovanni Giacomelli, Lucia Finocchio, Ilaria Biagini, Andrea Sodi, Vittoria Murro, Ugo Introini, Monica Varano, Francesco Bandello, Ugo Menchini
PURPOSE: To evaluate the long-term outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) drugs with a pro re nata (PRN) regimen for the treatment of choroidal neovascularization (CNV) secondary to angioid streaks (AS). METHODS: This is a retrospective, multicenter, noncomparative case series of consecutive AS eyes affected by treatment-naïve CNV. A complete ophthalmologic examination was performed every 30-45 days after the loading phase, including fluorescein angiography and/or optical coherence tomography...
June 23, 2017: Ophthalmologica. Journal International D'ophtalmologie
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