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https://www.readbyqxmd.com/read/29050187/-cytokine-analysis-of-aqueous-humor-in-aids-patients
#1
W J Kong, C G Guo, L Y Xie, W B Wei, H W Dong, C Chen, K F Du
Objective: To explore the Cytokine of aqueous humor in AIDS patients with different eye diseases. Methods: A case-control study including 38 patients who was diagnosed as acquired immunodeficiency syndrome(AIDS) at Infectious Center and Department of Ophthalmology in Beijing You'an Hospital, Capital Medical University. And 16 cases of 38 patients were cytomegalovirus retinitis (CMVR), 14 cases were HIV-related retinal disease, and 8 cases presented as normal. A series of tests were performed including vision acuity check, intraocular pressure, fundus photography, blood cell count of CD4+ T lymphocyte and the content of cytokines in aqueous humor by Luminex 200(TM) liquid chip analyzer...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044068/needle-stick-injuries-in-a-tertiary-eye-care-hospital-incidence-management-outcomes-and-recommendations
#2
Ekta Rishi, B Shantha, Abhinav Dhami, Pukhraj Rishi, Hannah C Rajapriya
PURPOSE: The purpose of this study is to assess the incidence, management, and outcomes for needle stick injuries (NSIs) in a tertiary eye-care hospital and provide appropriate recommendations for its prevention. METHODS: This was a retrospective database review of NSI recorded between 2010 and 2015 at a tertiary eye care center. All staff members who had NSI were managed with standard treatment protocol. The mode, location, health-care workers affected and/or at risk for NSI were analyzed...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29040008/analysis-of-the-clinical-profile-and-management-of-inflammatory-choriodal-neovascular-membranes-in-uveitic-eyes-a-study-from-a-tertiary-referral-center
#3
Sudha Ganesh, Arshee Ahmed, Jyotirmay Biswas
PURPOSE: To analyze clinical profile and management of inflammatory choroidal neovascularization (CNV) seen at a referral uveitis clinic. METHODS: Records of patients with uveitis and inflammatory CNV from January 1989 to April 2012 were retrieved and the data was analyzed. RESULTS: Forty-nine eyes of 43 patients were included. Mean age at presentation was 35.81 years. Eighteen eyes (36.7%) had infective etiology and 31 eyes (63.2%) had non-infective etiology...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29033535/differential-association-of-elevated-inflammatory-cytokines-with-postoperative-fibrous-proliferation-and-neovascularization-after-unsuccessful-vitrectomy-in-eyes-with-proliferative-diabetic-retinopathy
#4
Shigeo Yoshida, Yoshiyuki Kobayashi, Shintaro Nakao, Yukio Sassa, Toshio Hisatomi, Yasuhiro Ikeda, Yuji Oshima, Toshihiro Kono, Tatsuro Ishibashi, Koh-Hei Sonoda
BACKGROUND: Pars plana vitrectomy is the only treatment for advanced proliferative diabetic retinopathy (PDR). However, vitrectomy is not always successful despite current progress in vitreoretinal surgical techniques. The aim of our study was to investigate whether the vitreal concentrations of MCP-1, IL-6, IL-8, and VEGF are elevated after unsuccessful vitrectomy in patients with PDR and to investigate whether the altered levels of these cytokines are associated with the cause for the reoperation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29031854/angptl-4-induces-diabetic-retinal-inflammation-by-activating-profilin-1
#5
Qianyi Lu, Peirong Lu, Wei Chen, Li Lu, Zhi Zheng
Diabetic retinopathy (DR), the most common cause of irreversible blindness in working-age adults, results in central vision loss that is caused by microvascular damage to the inner lining of the back of the eye, the retina. The aim of this work was to assess the temporal relationships between angiopoietin-like protein-4 (ANGPTL-4), a novel adipocytokine factor, and diabetic retinal inflammation and microvascular dysfunction. The downstream pathway(s) and upstream mediator(s) of ANGPTL-4 were then determined under high glucose (HG) conditions...
October 12, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29030692/changes-in-aqueous-concentrations-of-various-cytokines-after-intravitreal-bevacizumab-and-subtenon-triamcinolone-injection-for-diabetic-macular-edema
#6
Seung-Young Yu, Dong Heun Nam, Dae Yeong Lee
PURPOSE: The purpose of this study was to compare the changes in the aqueous cytokine levels after intravitreal bevacizumab with those after combined intravitreal bevacizumab and subtenon triamcinolone injection in diabetic macular edema (DME). METHODS: This study examined 24 eyes of 23 patients with DME. Each patient with DME received randomly either an intravitreal injection of bevacizumab (IVBe) or IVBe with a subtenon triamcinolone injection (IVBe + STTA)...
October 13, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29030303/electrospun-formulations-of-bevacizumab-for-sustained-release-in-the-eye
#7
Ukrit Angkawinitwong, Sahar Awwad, Peng T Khaw, Steve Brocchini, Gareth R Williams
Medicines based on vascular endothelial growth factor (VEGF) neutralising antibodies such as bevacizumab have revolutionized the treatment of age related macular degeneration (AMD), a common blinding disease, and have great potential in preventing scarring after surgery or accelerating the healing of corneal injuries. However, at present, frequent invasive injections are required to deliver these antibodies. Such administration is uncomfortable for patients and expensive for health service providers. Much effort is thus focused on developing dosage forms that can be administered less frequently...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29026284/anti-vascular-endothelial-growth-factor-therapy-for-the-treatment-of-myopic-choroidal-neovascularization
#8
REVIEW
Colin S Tan, SriniVas R Sadda
Myopic choroidal neovascularization (CNV) is a sight-threatening condition which occurs in eyes with myopia, particularly in those with pathologic myopia. It is the most common cause of CNV among patients younger than 50 years. Hemorrhage and exudation from the CNV lesion may eventually result in scarring or chorioretinal atrophy. While myopic CNV was previously treated with focal laser photocoagulation or photodynamic therapy (PDT), the current treatment of choice is anti-vascular endothelial growth factor (VEGF) agents...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29025174/-change-in-therapy-of-neovascular-age-related-macular-degeneration-diabetic-maculopathy-and-macular-edema-after-retinal-vein-occlusion
#9
Matthias Grüb, Ioannis Lamprakis, Christoph Reichel
Background Therapy of neovascular age-related macular degeneration, diabetic maculopathy and macular edema after retinal vein occlusion has changed fundamentally since the introduction of anti-VEGF therapy more than 10 years ago. With the technological progress in ocular coherence tomography (OCT) functional criteria have been replaced by more morphological criteria. Contract law and administrative problems have been improved but not solved totally. Patients/Materials and Methods In a retrospective study, 207 eyes of 157 patients who presented between January 2007 and October 2013 with neovascular age-related macular degeneration, diabetic maculopathy or macular edema after retinal vein occlusion were analyzed...
October 12, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29023498/incidence-and-risk-factors-of-massive-subretinal-hemorrhage-in-retinal-angiomatous-proliferation
#10
Jae Hyung Lee, Mee Yon Lee, Won Ki Lee
OBJECTIVE: To evaluate the incidence and associated risk factors of massive subretinal hemorrhage (SRH) in patients with retinal angiomatous proliferation (RAP). METHODS: A total of 187 eyes of 135 treatment-naıve patients diagnosed with RAP were evaluated retrospectively. Clinical records including the time between the initial visit, last anti-vascular endothelial growth factor (VEGF) treatment, last stable examination, and the date of massive SRH were reviewed...
2017: PloS One
https://www.readbyqxmd.com/read/29018813/cardiovascular-consequences-of-repetitive-arousals-over-the-entire-sleep-duration
#11
Yanyan Wu, Rong Huang, Xu Zhong, Yi Xiao
OBJECTIVES: To explore the cardiovascular effects of nightlong repetitive arousals (RA). METHODS: Twenty healthy subjects participated in two consecutive sleep studies. The first one was free of intervention and the second study involved repetitive arousals induced by acoustical stimuli. Blood pressure, heart rate variability (HRV), arterial stiffness index (ASI), and serum markers including nitric oxide (NO), endothelin-1 (ET-1), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial growth factor (VEGF) were studied...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28994269/peripapillary-choroidal-thickness-change-of-polypoidal-choroidal-vasculopathy-after-anti-vascular-endothelial-growth-factor
#12
Kyou Ho Lee, Seo Hee Kim, Ji Min Lee, Eui Chun Kang, Hyoung Jun Koh
PURPOSE: To investigate the peripapillary choroidal thickness (PCT) of polypoidal choroidal vasculopathy (PCV) and exudative age-related macular degeneration (AMD) and to evaluate their responses to anti-vascular endothelial growth factor (VEGF). METHODS: Thirty eyes with PCV and 25 eyes with exudative AMD who were treatment naïve were included in this study. PCT and subfoveal choroidal thickness were evaluated both before and after intravitreal anti-VEGF. RESULTS: The initial mean PCT of PCV (153...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28993011/risk-factors-for-developing-choroidal-neovascular-membrane-and-visual-loss-in-punctate-inner-choroidopathy
#13
Rachael L Niederer, Rose Gilbert, Sue L Lightman, Oren Tomkins-Netzer
PURPOSE: To examine a large cohort of subjects with punctate inner choroidopathy (PIC) looking at risk factors for development of choroidal neovascular membrane (CNVM) and visual loss. DESIGN: Retrospective case series. PARTICIPANTS: A total of 203 participants (318 eyes) with PIC seen at Moorfields Eye Hospital between 1996 and 2016. METHODS: Information was gathered from the clinical notes of all subjects identified with PIC...
October 6, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28993010/early-and-late-retinal-pigment-epithelium-tears-after-anti-vascular-endothelial-growth-factor-therapy-for-neovascular-age-related-macular-degeneration
#14
Alessandro Invernizzi, Vuong Nguyen, Jennifer Arnold, Stephanie Young, Daniel Barthelmes, Mark C Gillies
PURPOSE: To investigate when retinal pigment epithelium (RPE) tears occur and their associated treatment patterns and long-term visual outcomes in patients with neovascular age-related macular degeneration (nAMD) during anti-vascular endothelial growth factor (VEGF) treatment. DESIGN: Case-control analysis from a prospectively designed observational database. PARTICIPANTS: Treatment-naïve eyes enrolled in the Fight Retina Blindness! observational study that commenced anti-VEGF treatment for nAMD between January 2006 and January 2017 were identified...
October 6, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28973045/the-expression-of-the-slit-robo-signal-in-the-retina-of-diabetic-rats-and-the-vitreous-or-fibrovascular-retinal-membranes-of-patients-with-proliferative-diabetic-retinopathy
#15
Weiyan Zhou, Hongya Wang, Wenzhen Yu, Wankun Xie, Min Zhao, Lvzhen Huang, Xiaoxin Li
PURPOSE: The Slit-Robo signal has an important role in vasculogenesis and angiogenesis. Our study examined the expression of Slit2 and its receptor, Robo1, in a rat model of streptozotocin-induced diabetes and in patients with proliferative diabetic retinopathy. METHODS: Diabetes was induced in male Sprague-Dawley rats via a single, intraperitoneal injection of streptozotocin. The rats were sacrificed 1, 3 or 6 months after the injection. The expression of Slit2 and Robo1 in retinal tissue was measured by real-time reverse transcription polymerase chain reaction (RT-PCR), and protein levels were measured by western blotting and immunohistochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28972027/choroidal-neovascularisation-triggered-multiple-evanescent-white-dot-syndrome-mewds-in-predisposed-eyes
#16
Thibaud Mathis, Benoit Delaunay, Armelle Cahuzac, Vivien Vasseur, Martine Mauget-Faÿsse, Laurent Kodjikian
BACKGROUND: Multiple evanescent white dot syndrome (MEWDS) is an inflammatory disease that can be associated with choroidalneovascularisation (CNV). However, few studies in the literature have described the occurrence of MEWDS in association with CNV. This paper discusses whether CNV can trigger MEWDS in a predisposed eye. METHODS: A retrospective multicentric case series of six eyes in six patients with acute onset of MEWDS and evidence of previous CNV was conducted between January 2015 and January 2017...
September 28, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28962144/the-effect-of-orbital-implantation-on-peripheral-blood-melatonin-and-sex-hormone-levels-in-child-patients-with-congenital-eyeball-dysplasia
#17
Junze Ma, Tao Liu, Jianqiang Qu
The aim of the study was to examine the effect of orbital implantation on peripheral blood melatonin and sex hormone levels in pediatric patients with congenital eyeball dysplasia. A total of 28 cases of pediatric patients with congenital eyeball dysplasia diagnosed in the Second Affiliated Hospital of Xi'an Jiaotong University from June 2014 to December 2014 were selected for the study. The patients included those that received orbital implantation, and the melatonin levels in the peripheral blood in patients before and after operation was observed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28946138/anti-vascular-endothelial-growth-factor-therapy-for-macular-edema-following-central-retinal-vein-occlusion-1-initial-injection-versus-3-monthly-injections
#18
Rie Osaka, Yuki Muraoka, Yuko Miwa, Koichiro Manabe, Mamoru Kobayashi, Yukari Takasago, Sotaro Ooto, Tomoaki Murakami, Kiyoshi Suzuma, Yuto Iida, Akitaka Tsujikawa
PURPOSE: To compare the 12-month efficacy of 1 initial intravitreal injection of an anti-vascular endothelial growth factor (VEGF) agent followed by pro re nata (PRN) dosing with that of 3 initial monthly injections followed by PRN dosing in patients with macular edema (ME) after central retinal vein occlusion (CRVO). METHODS: Twenty-nine eyes received 1 initial injection (1+PRN group) and 20 received 3 monthly injections (3+PRN group). RESULTS: At month 12, changes in logMAR visual acuity from baseline were -0...
September 26, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28937877/changes-in-peripapillary-nerve-fiber-layer-thickness-after-adjuvant-stereotactic-radiotherapy-in-patients-with-neovascular-age-related-macular-degeneration
#19
Mahdy Ranjbar, Maximilian Kurz, Annekatrin Holzhey, Dirk Rades, Salvatore Grisanti
PURPOSE: To evaluate the effect of stereotactic radiotherapy (SRT) in conjunction with intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) drugs on peripapillary retinal nerve fiber layer (pRNFL) thickness in patients with neovascular age-related macular degeneration (nAMD). METHODS: This was a retrospective, observational case series of patients with nAMD, who underwent SRT and subsequently had at least 12 months of complete follow-up...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937875/multiplex-cytokine-analysis-of-aqueous-humor-from-the-patients-with-chronic-primary-angle-closure-glaucoma
#20
Roopam Duvesh, George Puthuran, Kavitha Srinivasan, Venkatesh Rengaraj, S R Krishnadas, Sharmila Rajendrababu, Vijayakumar Balakrishnan, Pradeep Ramulu, Periasamy Sundaresan
PURPOSE: To compare the levels of cytokines and growth factor in aqueous humor of the patients with chronic primary angle closure glaucoma (PACG) and cataract. METHODS: Aqueous humor samples were collected from 19 chronic PACG patients and compared with 14 nonglaucomatous controls presenting for cataract surgery. The levels of 27 cytokines and growth factors were measured in the aqueous samples using multiplex bead immunoassay and compared across groups. RESULTS: Significantly higher levels of interleukin (IL)-8 (p < 0...
September 22, 2017: Current Eye Research
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