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https://www.readbyqxmd.com/read/28095147/management-of-small-renal-masses-american-society-of-clinical-oncology-clinical-practice-guideline
#1
Antonio Finelli, Nofisat Ismaila, Bill Bro, Jeremy Durack, Scott Eggener, Andrew Evans, Inderbir Gill, David Graham, William Huang, Michael A S Jewett, Sheron Latcha, William Lowrance, Mitchell Rosner, Bobby Shayegan, Houston R Thompson, Robert Uzzo, Paul Russo
Purpose To provide recommendations for the management options for patients with small renal masses (SRMs). Methods By using a literature search and prospectively defined study selection, we sought systematic reviews, meta-analyses, randomized clinical trials, prospective comparative observational studies, and retrospective studies published from 2000 through 2015. Outcomes included recurrence-free survival, disease-specific survival, and overall survival. Results Eighty-three studies, including 20 systematic reviews and 63 primary studies, met the eligibility criteria and form the evidentiary basis for the guideline recommendations...
January 17, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28095016/renal-masses-detected-on-fdg-pet-ct-in-patients-with-lymphoma-imaging-features-differentiating-primary-renal-cell-carcinomas-from-renal-lymphomatous-involvement
#2
Carlos Nicolau, Evis Sala, Anita Kumar, Debra A Goldman, Heiko Schoder, Hedvig Hricak, Hebert Alberto Vargas
OBJECTIVE: The purpose of this study is to analyze the (18)F-FDG PET/CT features of solid renal masses detected in patients with lymphoma and to evaluate the ability of PET/CT to differentiate renal cell carcinoma (RCC) from renal lymphomatous involvement. MATERIALS AND METHODS: Thirty-six patients with solid renal masses on PET/CT performed for staging or follow-up of lymphoma were evaluated retrospectively. The features recorded for each renal mass included the following standardized uptake values (SUVs) on PET/CT: the maximum SUV (SUVmax), the mean SUV (SUVmean), the ratio of the SUVmax of the tumor to that of the normal kidney cortex, the ratio of the SUVmean of the tumor to that of the normal kidney cortex, the ratio of the SUVmax of the tumor to that of the normal liver, and the ratio of the SUVmean of the tumor to that of the normal liver...
January 17, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28093293/core-needle-biopsy-and-fine-needle-aspiration-alone-or-in-combination-diagnostic-accuracy-and-impact-on-management-of-renal-masses
#3
F Cate, M Kapp, S A Arnold, L L Gellert, O Hameed, P E Clark, G Wile, A Coogan, G A Giannico
PURPOSE: Fine needle aspiration (FNA) with and without concurrent core needle biopsy (CNB) is a minimally invasive method to diagnose and assist in management of renal masses. We aimed to assess the pathologic accuracy of FNA compared to and associated with CNB, and impact on management. MATERIALS AND METHODS: This is a single institution retrospective study of 342 cases from 2001 to 2015 with small and large renal masses (≤4 and >4 cm). Diagnostic and concordance rates and impact on management were analyzed...
January 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28087475/immunohistochemical-approach-for-the-diagnosis-of-a-liver-mass-on-small-biopsy-specimens
#4
Won-Tak Choi, Rageshree Ramachandran, Sanjay Kakar
Well-differentiated hepatocellular carcinoma (HCC) shares overlapping histological features with benign hepatocellular lesions, including hepatocellular adenoma (HCA) and focal nodular hyperplasia (FNH) in non-cirrhotic liver, and with high-grade dysplastic nodule (HGDN) in cirrhotic liver. Several metastatic tumors, such as neuroendocrine tumor, renal cell carcinoma, adrenocortical carcinoma, melanoma, and epithelioid angiomyolipoma, can be indistinguishable from HCC on histologic grounds. Since this distinction has important therapeutic implications, judicious use of immunohistochemical markers plays an important role in establishing an accurate diagnosis, especially when limited material of tumor is available on cell block or a small core biopsy...
January 10, 2017: Human Pathology
https://www.readbyqxmd.com/read/28076721/effect-of-tumor-complexity-and-technique-on-efficacy-and-complications-after-percutaneous-microwave-ablation-of-stage-t1a-renal-cell-carcinoma-a-single-center-retrospective-study
#5
Marki E Klapperich, E Jason Abel, Timothy J Ziemlewicz, Sara Best, Meghan G Lubner, Stephen Y Nakada, J Louis Hinshaw, Christopher L Brace, Fred T Lee, Shane A Wells
Purpose To evaluate the effects of tumor complexity and technique on early and midterm oncologic efficacy and rate of complications for 100 consecutive biopsy-proved stage T1a renal cell carcinomas (RCCs) treated with percutaneous microwave ablation. Materials and Methods This HIPAA-compliant, single-center retrospective study was approved by the institutional review board. The requirement to obtain informed consent was waived. Ninety-six consecutive patients (68 men, 28 women; mean age, 66 years ± 9.4) with 100 stage T1a N0M0 biopsy-proved RCCs (median diameter, 2...
January 11, 2017: Radiology
https://www.readbyqxmd.com/read/28072625/evaluation-of-a-large-renal-mass-using-99mtc-mibi-spect-ct-in-a-patient-with-chronic-kidney-disease
#6
Steven P Rowe, Michael A Gorin, Mehrbod S Javadi, Mohamad E Allaf
The differentiation of benign and indolent renal masses from aggressive tumor histologies cannot be reliably performed by CT or MRI. Additionally, renal mass biopsy risks complications and has a nondiagnostic rate of 10% to 20%. Tc-MIBI SPECT/CT has been shown to allow for the accurate differentiation of benign renal oncocytomas and hybrid oncocytic/chormophobe tumors from other more aggressive renal tumor types. We present the case of an 84-year-old man with chronic kidney disease and an 11.2-cm renal mass...
January 9, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28065429/eyelid-metastasis-as-first-presentation-of-renal-cell-carcinoma
#7
R Cabrera-Beyrouti, E Campos-Mollo, E Rico-Santos, D N Jiménez-Rodríguez, M Lledó-Riquelme, J Vierna-García
CASE REPORT: An 87-year-old male presented with a slow-growing, painless and well defined nodule in the upper eyelid. The tumour measured 1cm, and was pigmented and adhered to deep planes. The histopathology analysis was compatible with renal cell carcinoma. The extension study showed a tumour mass in each kidney, as well as multiple pulmonary metastases. DISCUSSION: The ophthalmologist can play an important role in the diagnosis of metastatic cancer when eye disease is present...
January 5, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28061891/the-dangers-of-parathyroid-biopsy
#8
Joanne Kim, Gilad Horowitz, Michael Hong, Mario Orsini, Sylvia L Asa, Kevin Higgins
BACKGROUND: We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement. CASE PRESENTATION: There was clinical suspicion for parathyroid carcinoma, further supported by intra-operative findings. However, the final pathology described a primary hyperceullar parathyroid lesion with pathognomonic changes secondary to fine-needle aspiration (FNA) biopsy, along with a separate parathyroid lesion likely resulting from seeding along the needle tract...
January 7, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28058773/surgical-histopathology-for-suspected-oncocytoma-on-renal-mass-biopsy-a-systematic-review-and-meta-analysis
#9
REVIEW
Hiten D Patel, Sasha C Druskin, Steven P Rowe, Phillip M Pierorazio, Michael A Gorin, Mohamad E Allaf
OBJECTIVE: To estimate the proportion of oncocytic renal neoplasms diagnosed on renal mass biopsy (RMB) confirmed on surgical pathology. MATERIALS AND METHODS: A systematic review of MEDLINE, Embase, and the Cochrane databases (1997-July 1, 2016) was conducted to quantify all cases of reported oncocytic renal neoplasms on RMB suggestive of an oncocytoma. In addition, institutional data was assessed to identify additional cases. Concordance with surgical histopathology (positive predictive value) was evaluated for patients undergoing surgery by performing a meta-analysis...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28050791/radiological-diagnosis-of-perinephric-pathology-pictorial-essay-2015
#10
REVIEW
Goran Mitreski, Tom Sutherland
: The perinephric space, shaped as an inverted cone, sits between the anterior and posterior renal fasciae. It can play host to a variety of clinical conditions encountered daily in the reporting schedule for a radiologist. Lesions may be classified and diagnosed based on their imaging characteristics, location and distribution. A broad range of differential diagnoses can be attributed to pathology sitting within this space, often without clinical signs or symptoms. An understanding of commonly encountered conditions affecting the perinephric space, along with characteristic imaging findings, can illustrate and often narrow the likely diagnosis...
January 3, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28050435/mucinous-cystadenocarcinoma-in-a-horse-shoe-kidney-masquerading-as-giant-hydronephrosis-a-case-report-diagnostic-challenges-lessons-learnt-and-review-of-literature
#11
Leena Dennis Joseph, Sriram Krishnamoorthy, Rajendiran Swaminathan, Gokul Kripesh, Hariharasudhan Sekar
Primary epithelial tumour of the renal pelvis is a rare entity. So far, very few cases are reported in literature. Of these, mucin secreting adenocarcinomas are distinctly rare. However, mucinous cystadenocarcinoma, that too arising in a horse shoe kidney is extremely rare to be reported. Mucinous cystadenomas and carcinomas arising from the renal pelvis are regarded to be secondary to a metaplastic change in the urothelium. Here, we present a case of a 51-year-old male, who complained of abdominal pain, palpable abdominal mass, haematuria along with passage of mucoid material in the urine, with a very poorly functioning kidney...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050384/inflammatory-myofibroblastic-tumor-of-the-kidney-a-rare-renal-tumor
#12
Alvin Jose Pothadiyil, Suresh Bhat, Fredrick Paul, Jithesh Mampatta, Mahesh Srinivas
Inflammatory Myofibroblastic Tumour (IMT) or 'pseudotumour' of the kidney is a rare benign tumour of unknown aetiology affecting mostly young adults. A subset of IMT is neoplastic and harbours translocations of activin receptor-like kinase-1 (ALK-1) gene and can recur or rarely metastasize. Presentation varies from an incidentaloma to gross haematuria. Clinical examination and radiological investigations are usually inconclusive. Often, biopsy is inconclusive necessitating a management similar to that of Renal Cell Cancer (RCC)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050001/light-chain-deposition-disease-diagnosed-with-laser-micro-dissection-liquid-chromatography-and-tandem-mass-spectrometry-of-nodular-glomerular-lesions
#13
Tomomichi Kasagi, Hironobu Nobata, Keisuke Suzuki, Naoto Miura, Shogo Banno, Akiyoshi Takami, Taro Yamashita, Yukio Ando, Hirokazu Imai
A 42-year-old man developed nephrotic syndrome and rapidly progressive renal failure. Kidney biopsy demonstrated nodular glomerulosclerosis, negative Congo red staining, and no deposition of light or heavy chains. Laser micro-dissection and liquid chromatography with tandem mass spectrometry of nodular lesions revealed the presence of a kappa chain constant region and kappa III variable region, which signified light chain deposition disease. Dexamethasone and thalidomide were effective in decreasing the serum levels of free kappa light chain from 147...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28024966/office-based-ultrasound-guided-renal-core-biopsy-is-safe-and-efficacious-in-the-management-of-small-renal-masses
#14
Chirag N Dave, Brian Seifman, Avinash Chennamsetty, Rene Frontera, Kassem Faraj, Ryan Nelson, Colleen Lucido, Edward W Schervish
OBJECTIVE: To evaluate the safety and efficacy of ultrasound (US)-guided percutaneous renal mass biopsy (RMB) performed in the office setting by urologists. MATERIALS AND METHODS: This is a retrospective study involving patients who underwent office-based US-guided percutaneous RMB between April 2010 and October 2015. Baseline vital signs and US were performed prior to the procedure. Patients were then observed for 1 hour after the procedure and repeat vital signs and US were performed...
December 23, 2016: Urology
https://www.readbyqxmd.com/read/28011890/idiopathic-myelofibrosis-with-disseminated-hepatosplenic-mesenteric-renal-and-pulmonary-extramedullary-haematopoeisis-portal-hypertension-and-tuberculosis-initial-presentation-and-2%C3%A2-years-follow-up
#15
Ananya Panda, Sheragaru Hanumanthappa Chandrashekhara, Aruna Nambirajan, Pravas Mishra
A 35-year-old man with a 12-year history of idiopathic myelofibrosis (IMF) presented in 2014 with fatigue and abdominal distension. CT scan revealed massive hepatosplenomegaly with focal splenic lesions, soft tissue around renal pelvis, mesenteric masses compressing bowel loops and perilymphatic nodules in lungs. There was portal hypertension, ascites, pleural effusion, bilateral psoas abscesses and necrotic retroperitoneal lymphadenopathy. MRI additionally revealed hypointense periportal infiltrative lesions in liver, not seen on CT scan...
December 23, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27988214/characterization-of-glomerular-extracellular-matrix%C3%A2-by-proteomic-analysis-of-laser-captured-microdissected-glomeruli
#16
Liliane Hobeika, Michelle T Barati, Dawn J Caster, Kenneth R McLeish, Michael L Merchant
Abnormal extracellular matrix (ECM) remodeling is a prominent feature of many glomerular diseases and is a final common pathway of glomerular injury. However, changes in ECM composition accompanying disease-related remodeling are unknown. The physical properties of ECM create challenges for characterization of composition using standard protein extraction techniques, as the insoluble components of ECM are frequently discarded and many ECM proteins are in low abundance compared to other cell proteins. Prior proteomic studies defining normal ECM composition used a large number of glomeruli isolated from human kidneys retrieved for transplantation or by nephrectomy for cancer...
February 2017: Kidney International
https://www.readbyqxmd.com/read/27984204/noninvasive-diagnosis-of-chronic-kidney-diseases-using-urinary-proteome-analysis
#17
Justyna Siwy, Petra Zürbig, Angel Argiles, Joachim Beige, Marion Haubitz, Joachim Jankowski, Bruce A Julian, Peter G Linde, David Marx, Harald Mischak, William Mullen, Jan Novak, Alberto Ortiz, Frederik Persson, Claudia Pontillo, Peter Rossing, Harald Rupprecht, Joost P Schanstra, Antonia Vlahou, Raymond Vanholder
BACKGROUND: In spite of its invasive nature and risks, kidney biopsy is currently required for precise diagnosis of many chronic kidney diseases (CKDs). Here, we explored the hypothesis that analysis of the urinary proteome can discriminate different types of CKD irrespective of the underlying mechanism of disease. METHODS: We used data from the proteome analyses of 1180 urine samples from patients with different types of CKD, generated by capillary electrophoresis coupled to mass spectrometry...
October 5, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27957371/a-rare-cause-of-nasal-obstruction-metastatic-renal-cell-carcinoma
#18
Tuba Dilay Kokenek-Unal, B Gumuskaya, B Ocal, Murat Alper
Introduction. Renal cell carcinoma can present with several interesting symptoms, paraneoplastic syndromes, and unusual metastatic sites. Head and neck region is one of the rare locations for renal cell carcinoma metastasis. Case Report. A 50-year-old man was admitted to the hospital with nasal congestion and snoring. Physical examination revealed nasal serous secretion. First taken biopsy was misinterpreted. The symptoms of the patient were not revealed and he was readmitted to the hospital. On radiologic examination, a vascular rich mass in maxillary sinus extending to the nasal cavity was observed...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27956733/metastatic-renal-cell-carcinoma-in-the-thyroid-gland-ultrasonographic-features-and-the-diagnostic-role-of-core-needle-biopsy
#19
Ok Kyu Song, Ja Seung Koo, Jin Young Kwak, Hee Jung Moon, Jung Hyun Yoon, Eun-Kyung Kim
Purpose: The aims of this study were to present the ultrasonographic (US) features of metastatic renal cell carcinoma (RCC) in the thyroid gland and to evaluate the diagnostic utility of fineneedle aspiration (FNA) and core needle biopsy (CNB). Methods: Eight patients with nine metastatic RCC nodules in the thyroid glands who were treated from January 2002 to March 2015 in a single tertiary hospital were consecutively selected and retrospectively reviewed. US features and clinical history were obtained from the institution's medical database...
November 9, 2016: Ultrasonography
https://www.readbyqxmd.com/read/27900022/conversion-of-aspergilloma-to-chronic-necrotizing-pulmonary-aspergillosis-following-treatment-with-sunitinib-a-case-report
#20
Yeon Wook Kim, Hyun Woo Lee, Jaeyoung Cho, Han-Sol Choi, Jungsil Lee, Sung Soo Park, Eun Young Heo, Kwang Nam Jin, Deog Kyeom Kim
Semi-invasive or invasive aspergillosis occurring following chemotherapy with sunitinib is a rare condition with unknown incidence and prognosis. Here, we report a case involving a 59-year-old male who had a history of underlying stable aspergilloma and was newly diagnosed with metastatic renal cell carcinoma. Following surgical resection for renal cell carcinoma and adjuvant chemotherapy with sunitinib for 8 months, the patient presented with hemoptysis. Chest computed tomography revealed an increased soft tissue mass and air crescent sign of the underlying aspergilloma, combined with consolidation and bronchial artery hypertrophy around the lesion...
November 2016: Oncology Letters
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