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https://www.readbyqxmd.com/read/29760223/genomic-heterogeneity-and-the-small-renal-mass
#1
Daiki Ueno, Zuoquan Xie, Marta Boeke, Jamil Syed, Kevin A Nguyen, Patrick McGillivray, Adebowale Adeniran, Peter A Humphrey, Garrett M Dancik, Yuval Kluger, Zongzhi Liu, Harriet M Kluger, Brian Shuch
PURPOSE: Tumor heterogeneity may represent a barrier to pre-operative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The extent of heterogeneity in small renal tumors remains unknown. Therefore, we set out to evaluate heterogeneity in resected large and small renal tumors. EXPERIMENTAL DESIGN: We conducted a study from 2013 through 2016, that evaluated 47 consecutive ccRCC tumors resected during radical or partial nephrectomy...
May 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29755405/dual-paraneoplastic-endocrine-syndromes-heralding-onset-of-extrapulmonary-small-cell-carcinoma-a-case-report-and-narrative-review
#2
Jill B Feffer, Natalia M Branis, Jeanine B Albu
Objective: Extrapulmonary small cell carcinoma (EPSCC) is rare and frequent metastases at presentation can complicate efforts to identify a site of origin. In particular, SCC comprises <1% of prostate cancers and has been implicated in castration resistance. Methods: Clinical, laboratory, imaging, and pathology data are presented. Results: A 56-year-old man with locally advanced prostate adenocarcinoma on androgen deprivation therapy presented with a clogged nephrostomy tube...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29730017/positron-emission-tomography-computed-tomography-with-89-zr-girentuximab-can-aid-in-diagnostic-dilemmas-of-clear-cell-renal-cell-carcinoma-suspicion
#3
Marlène C H Hekman, Mark Rijpkema, Erik H Aarntzen, Sasja F Mulder, Johan F Langenhuijsen, Egbert Oosterwijk, Otto C Boerman, Wim J G Oyen, Peter F A Mulders
Based on the high expression of carbonic anhydrase IX (CAIX) in 95% of clear cell renal cell carcinoma (ccRCC), the anti-CAIX monoclonal antibody girentuximab can be used for the detection of ccRCC. This clinical study explores the value of 89 Zr-labeled girentuximab positron emission tomography/computed tomography (PET/CT) imaging in diagnostic challenges regarding ccRCC. PET/CT imaging was performed 4 or 5 d after injection of 89 Zr-girentuximab in patients with a primary renal mass (n=16) or a history of ccRCC (n=14)...
May 2, 2018: European Urology
https://www.readbyqxmd.com/read/29719489/renal-manifestation-of-birt-hogg-dub%C3%A3-syndrome-depicted-by-18f-fludeoxyglucose-positron-emission-tomography-computed-tomography-in-a-patient-with-hurtle-cell-thyroid-malignancy
#4
Emmanouil Panagiotidis, Nagabhushan Seshadri, Sobhan Vinjamuri
Birt-Hogg-Dubé (BHD) syndrome is an autosomal dominant genetic disorder characterized by small papular skin lesions (fibrofolliculomas) causing susceptibility to kidney cancer, renal and pulmonary cysts, spontaneous pneumothoraces, and several noncutaneous tumors. We report a case of a 67-year-old woman, with a previous history of right hemithyroidectomy for adenomatous lesion. She presented with a swelling in the right thyroid bed that on subsequent biopsy revealed features of metastatic carcinoma. 18F-fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) performed for the detection of primary malignancy showed increased high-grade metabolic activity in the right supraclavicular soft tissue mass extending into the superior mediastinum...
April 2018: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29708949/the-genomics-of-renal-cell-carcinoma-and-its-role-in-renal-mass-biopsy
#5
Simpa S Salami, Arvin K George, Aaron M Udager
PURPOSE OF REVIEW: Large-scale genomic profiling has shed new light on the molecular underpinnings of renal cell carcinoma (RCC), spurring a much needed refinement of RCC subclassification based on an integrative assessment of histopathologic features and molecular alterations. At the same time, renal mass biopsies have become increasingly commonplace, necessitating ancillary tools to help guide clinical management. Herein, we briefly review our current understanding of RCC genomics, highlighting areas of possible clinical utility, as well as potential limitations, for renal mass biopsies...
April 27, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29704388/unrecognised-igg4-association-in-progressively-transformed-germinal-centers-of-lymph-nodes-with-subsequent-full-blown-igg4-related-chronic-fibrosing-pancreatitis-a-case-report
#6
H J Son, H Lee, J H Kim, I K Yu, H Y Han
Progressively transformed germinal centers (PTGC) is a benign process characterised by a morphological variant of reactive follicular hyperplasia in lymph nodes. It was recently shown that some cases of PTGC are associated with IgG4-related disease (IgG4-RD) or increased IgG4 plasma cells. Five years ago, a 57-year-old woman presented with enlargement of multiple lymph nodes in the left parotid, submandibular, and neck areas, pathologically diagnosed as PTGC after excisional biopsy. Since then, she has experienced numbness in her extremities, especially the left shoulder and arm, pruritus on the left side of the face and intermittent facial palsy, for which she has been receiving regular symptomatic treatment...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29697474/percutaneous-renal-biopsy-approach-diagnostic-accuracy-and-risks
#7
Taylor Capretz, Roshan M Patel, Zhamshid Okhunov
PURPOSE OF REVIEW: This article provides a review of recent advances and issues regarding the controversial topic of renal mass biopsy (RMB). The purpose of this review is to provide an update on the current status of renal biopsy based on recently published literature. Here, we particularly focus on articles that have been published within the last 12 months. RECENT FINDINGS: The main topics covered in this review are the approach, diagnostic accuracy and risks related to RMB...
April 24, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29697471/roles-for-active-surveillance-in-renal-cancer
#8
Jaime O Herrera-Caceres, Michael A S Jewett
PURPOSE OF REVIEW: With this review, we describe the most recent advances in active surveillance as well as diagnosis and management of small renal masses (SRMs). RECENT FINDINGS: We discuss diagnosis, differentiation of solid from cystic lesions, risk prediction and treatment of the SRM. A better understanding of the disease facilitates the use of more conservatory treatments, such as active surveillance. Active surveillance has been increasingly accepted not only for SRM, but also for larger tumors and even metastatic patients...
April 24, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29696566/outcomes-of-ultrasound-guided-renal-mass-biopsies
#9
Edward L Sutherland, Agnieszka Choromanska, Sayf Al-Katib, Mary Coffey
PURPOSE: The purpose of this study was to evaluate the rate of nondiagnostic ultrasound-guided renal mass biopsies (RMBs) at our institution and to determine what patient, procedural, and focal renal mass (FRM) factors were associated with nondiagnostic ultrasound-guided RMBs. METHODS: Eighty-two ultrasound-guided renal mass biopsies performed between January 2014 and October 2016 were included in our study. Biopsy outcomes (diagnostic vs. nondiagnostic) and patient, procedural, and FRM characteristics were retrospectively reviewed and recorded...
April 25, 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/29692990/membranous-nephropathy-like-apolipoprotein-e-deposition-disease-with-apolipoprotein-e-toyonaka-ser197cys-and-a-homozygous-apolipoprotein-e2-2
#10
Megumu Fukunaga, Kiyotaka Nagahama, Michiko Aoki, Akira Shimizu, Shigeo Hara, Akira Matsunaga, Eri Muso, Takao Saito
A 20-year-old female student underwent renal biopsy because of chance proteinuria and hematuria. Histological study revealed a membranous nephropathy-like appearance by light microscopy. But immunoglobulins and complements were negative in the glomerulus by immunofluorescence study. On the other hand, plasma apolipoprotein E (ApoE) concentration was elevated to more than 2 times the normal range, and the phenotype, genotype, and DNA sequence studies of her ApoE showed homozygous ApoE2/2 and a heterozygous novel missense mutation called ApoE Toyonaka (Ser197Cys)...
January 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29684961/-a-case-of-renal-cell-carcinoma-growing-into-the-renal-pelvis-with-a-fibrin-cap-in-the-ureter-and-bladder
#11
Tatsuro Ishikawa, Koji Izumi, Takuya Kondo, Ken Miyama, Yutaka Osada, Junnichi Ota
We present a case of renal cell carcinoma growing into the renal pelvis with a fibrin cap in the ureter and bladder. A 66-year-old man presented to our hospital with anemia and gross hematuria. Computed tomography showed a large left renal tumor and space-occupying lesions in the left renal pelvis and ureter. Cystoscopy showed a 2 cm-restiform mass protruding from the left ureteral orifice. We performed open left nephroureterectomy, and there was a 3 cm white mass with a smooth surface in the bladder. Pathological examination of the resected mass revealed clear cell carcinoma with urinary collecting system invasion and fibrin cap in the ureter and bladder...
March 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29684947/-a-case-of-solitary-metastasis-of-renal-cell-carcinoma-to-the-thyroid-gland
#12
Yuki Yokoi, Kengo Yasuda, Hideyuki Terao, Shinpei Sugiura, Kazuo Kitami, Yuzo Minegishi, Shunichi Gondo
A case of solitary metastasis of renal cell carcinoma to the thyroid gland is presented. The patient was a 82-year-old man found to have an abnormal mass in his neck. He had a past history of renal clear cell carcinoma of the left kidney (pT1aN0M0, G1>2, alveolar type, clear cell subtype), which had been resected 12 years previously. Ultrasonography revealed a tumor mass in the right hemithyroid gland. This time fine needle biopsy of the thyroid tumor suggested metastatic thyroid carcinoma. Right hemithyroidectomy was performed last year...
February 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29682611/unilateral-renal-tumor-cryoablation-and-contralateral-radical-nephrectomy-of-bilateral-renal-tumors-by-transumbilical-3d-multichannel-laparoendoscopic-single-site-surgery
#13
Guopeng Yu, Ke Zhang, Wenzhi Li, Long Li, Yanliang Zhao, Yiwei Wang, Mingxi Xu, Jun Da, Guoqin Dong, Zhong Wang, Bin Xu
Background: Unilateral renal tumor cryoablation and contralateral radical nephrectomy of bilateral renal tumors were performed by transumbilical three-dimensional (3D) multichannel laparoendoscopic single-site (LESS) surgery, in an attempt to verify the feasibility and safety of the procedure, sum up the operational experience, and evaluate the surgical outcome. Case Presentation: This was a 47-year-old female patient with a body mass index of 27.34 kg/m2 without backache, low back pain, hematuria, urinary urgency, frequent urination, dysuria, and other symptoms...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29681695/use-of-pretherapy-core-biopsy-in-the-diagnosis-of-pediatric-renal-tumors
#14
Jujju Jacob Kurian, Kenneth R L Nongpiur, Susan Jehangir
Background: Pretreatment core biopsy of pediatric renal tumors has been advocated by United Kingdom Children's Cancer Study Group to circumvent the disadvantage of International Society of Paediatric Oncology protocol, where neoadjuvant chemotherapy initiated without histopathological confirmation can result in over- or under-treatment. Aim: This study aims (a) to assess if pretherapy core biopsy correlates with the nephrectomy biopsy; (b) to assess if neoadjuvant chemotherapy changes Wilms tumor (WT) histology, and (c) to assess the incidence of biopsy site recurrence...
April 2018: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/29665739/pax8-positive-b-cell-lymphoma-in-adrenal-gland-masquerading-as-metastatic-renal-cell-carcinoma
#15
Rugvedita Parakh, Lin Cheng, Maria Tretiakova
Extranodal lymphomas involve adrenal glands as a mass lesion in 3% to 5% of cases as identified by imaging studies. Definitive diagnosis of the neoplasm is provided by morphological and immunophenotypical evaluation on limited tissue obtained by fine needle aspiration or core biopsy. We report a diagnostically challenging case that presented as masses involving adrenal gland and lung in the setting of a concurrent primary renal cell carcinoma. PAX8, a frequently used marker for renal cell carcinoma, was immunoreactive in the neoplastic cells of the adrenal mass, and thus highly suggestive for metastatic renal cell carcinoma...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29657199/impact-of-body-mass-index-on-progression-of-primary-immunoglobulin-a-nephropathy
#16
Shankar Prasad Nagaraju, Dharshan Rangaswamy, Aswani Srinivas Mareddy, Srikanth Prasad, Sindhu Kaza, Srinivas Shenoy, Karan Saraf, Ravindra Prabhu Attur, Rajeevalochana Parthasarathy, Srinivas Kosuru, Uday Venkat Mateti, Vasudeva Guddattu, Sindhura Lakshmi Koulmane Laxminarayana
The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29653161/is-routine-use-of-renal-tumor-biopsy-associated-with-lower-rates-of-benign-histology-following-nephrectomy-for-small-renal-masses
#17
Patrick O Richard, Luke T Lavallée, Frederic Pouliot, Maria Komisarenko, Lisa Martin, Jean-Baptiste Latouff, Antonio Finelli
PURPOSE: Renal tumor biopsies (RTBs) have been proposed as a management alternative to avoid treatment of benign or low-risk small renal masses (SRMs). However, many urologists are reluctant to recommend RTB because they feel its result frequently will not impact management. Our primary objective was to evaluate if centers that routinely favor RTB (FRB) have lower rates of benign histology after surgery than centers that use a selective RTB approach (SRB). METHODS: This was a retrospective multicenter study of patients who underwent a partial or radical nephrectomy for a lesion suspicious for localised RCC and measuring ≤4cm (cT1a and pT1a or pT3a) between 2013 and 2015...
April 10, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29629862/identifying-the-use-and-barriers-to-the-adoption-of-renal-tumour-biopsy-in-the-management-of-small-renal-masses
#18
Patrick O Richard, Lisa Martin, Luke T Lavallée, Philippe D Violette, Maria Komisarenko, Andrew J Evans, Kunal Jain, Michael A S Jewett, Antonio Finelli
INTRODUCTION: Renal tumour biopsies (RTBs) can provide the histology of small renal masses (SRMs) prior to treatment decision making. However, many urologists are reluctant to use RTB as a standard of care. This study characterizes the current use of RTB in the management of SRMs and identifies barriers to a more widespread adoption. METHODS: A web-based survey was sent to members of the Canadian and Quebec Urological Associations who had registered email address (n=767) in June 2016...
April 6, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29620664/adult-renal-neuroblastoma-a-case-report-and-literature-review
#19
REVIEW
Ming-De Huang, Li-Sheng Hsu, Huei-Chieh Chuang, Wei-Yu Lin, Wei-Hsiu Lin, Chih-Wei Yen, Min-Lang Chen
RATIONALE: Adult renal neuroblastoma (NB) is extremely rare, and there have been only a few cases previously described in the literature. We report a case of adult renal NB and summarize the clinical and imaging features of the reported cases. PATIENT CONCERNS: A 41-year-old female was admitted to our hospital with a chief complaint of gross hematuria that had persisted for a month. Nonenhanced computed tomography (CT) revealed a hypodense right renal mass without calcification...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29595650/accuracy-and-safety-of-ultrasound-guided-percutaneous-needle-core-biopsy-of-renal-masses-a-single-center-experience-in-china
#20
Xianding Wang, Yuanhang Lv, Zilin Xu, Muguo Aniu, Yang Qiu, Bing Wei, Xiaohong Li, Qiang Wei, Qiang Dong, Tao Lin
Our aim is to determine the sufficiency, accuracy, and safety of ultrasound-guided percutaneous needle core biopsy of renal masses in Chinese patients.Patients who had undergone ultrasound-guided needle core renal mass biopsy from June 2012 to June 2016 at West China Hospital, China were retrospectively reviewed. The information obtained included demographics, mass-related parameters, biopsy indications, technique, complications, pathologic results, and follow-up. Concordance of surgical resection pathology and follow-up data were assessed...
March 2018: Medicine (Baltimore)
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