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Lens luxation

Jonas Donner, Maria Kaukonen, Heidi Anderson, Fredrik Möller, Kaisa Kyöstilä, Satu Sankari, Marjo Hytönen, Urs Giger, Hannes Lohi
BACKGROUND: The growing number of identified genetic disease risk variants across dog breeds challenges the current state-of-the-art of population screening, veterinary molecular diagnostics, and genetic counseling. Multiplex screening of such variants is now technologically feasible, but its practical potential as a supportive tool for canine breeding, disease diagnostics, pet care, and genetics research is still unexplored. RESULTS: To demonstrate the utility of comprehensive genetic panel screening, we tested nearly 7000 dogs representing around 230 breeds for 93 disease-associated variants using a custom-designed genotyping microarray (the MyDogDNA® panel test)...
2016: PloS One
Jury Kim, Young-Jun Kim, Dong-Beom Ji, Min-Su Kim
A slow loris, Nycticebus coucang , was brought to Ji Dong Beom Animal Hospital from the National Institute of Ecology due to globe enlargement and frequent blepharospasm of the right eye. Ophthalmic diagnoses included glaucoma with posterior lens luxation and cataract. Because this animal was on exhibition at the National Institute of Ecology, preservation of the eyeball by intraocular silicone implantation following evisceration rather than enucleation was selected. Before the surgery, examination of the normal left eye was performed using Retcam and spectral domain optical coherence tomography...
June 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Argyrios Tzamalis, Chrysanthos Symeonidis, Irini P Brazitikou, Dimitra Tzetzi, Nikos Chalvatzis, Sofia Androudi, Periklis Brazitikos
PURPOSE: To describe the safety and efficacy of removing posteriorly dislocated lens fragments with the use of intravitreal ultrasonic fragmentation through a limbal, clear cornea self-sealing incision. METHODS: Patients presenting with posteriorly luxated nuclei were enrolled in this prospective case series. Preoperative examination included evaluation of the corneal endothelium by means of specular microscopy. A 3-port 25+ pars plana vitrectomy was initially performed...
July 14, 2016: Retina
Kristen M O'Connell, Tammy M Michau, Jessica M Stine, Andrea T Reid
OBJECTIVE: To establish reference values and report ophthalmic examination findings in a colony of captive brown pelicans (Pelecanus occidentalis). DESIGN: Descriptive study. ANIMALS STUDIED: Sixty-three captive brown pelicans in Florida were examined. PROCEDURES: A complete ophthalmic examination including Schirmer tear test (STT), applanation tonometry, fluorescein stain, biomicroscopy, and direct and indirect ophthalmoscopy was performed...
May 18, 2016: Veterinary Ophthalmology
Alexander Melamud, James S Topilow, Ling Cai, Xin He
PURPOSE: To compare visual outcomes among eyes that underwent pars plana vitrectomy (PPV) in combination with either anterior chamber intraocular lens implantation (ACIOL) or scleral suturing of posterior chamber lens (PCIOL). DESIGN: Retrospective comparative case series. METHODS: All eyes presented with aphakia or luxated or subluxated posterior chamber intraocular lens (IOL) following complicated cataract surgery, trauma, or spontaneous dislocation...
August 2016: American Journal of Ophthalmology
Diego Ruiz-Casas, Juan Gros-Otero, Alfonso Casado
PURPOSE: To describe a surgical technique for complete and safe dexamethasone intravitreal implant (Ozurdex; Allergan, Inc., Irvine, CA) removal from anterior chamber. METHODS: Description of a new surgical technique for Ozurdex removal using a lens injector cartridge. RESULTS: Dexamethasone implant was removed completely from anterior chamber with no damage to corneal endothelium or posterior chamber luxation in a patient with Ozurdex anterior chamber migration...
October 2016: Retinal Cases & Brief Reports
Elise Donzel, Léa Arti, Sabine Chahory
OBJECTIVE: To determine the epidemiology and the clinical presentation of cataracts in a population of dogs in France. PROCEDURES: Records of dogs affected by a cataract presented at the Ophthalmology Unit of Alfort Veterinary School during 2009-2012 were reviewed. The etiology was determined for each dog. The signalment of affected dogs, their medical history, age of onset, stage of progression, location of opacities, and ocular lesions associated were evaluated for each etiology...
April 7, 2016: Veterinary Ophthalmology
Seita Morishita, Masanori Fukumoto, Hiroyuki Suzuki, Takaki Sato, Teruyo Kida, Eisuke Isizaki, Mari Ueki, Tetsuya Sugiyama, Tsunehiko Ikeda
BACKGROUND: We encountered a rare patient with lens luxation in which the lens had become stuck on the optic disc. Findings obtained during vitreous surgery suggested that the luxated lens had become stuck on the optic disc via residual vitreous gel. CASE PRESENTATION: An 88-year-old Japanese man experienced lens luxation into the inferior vitreous cavity while undergoing treatment for glaucoma in his left eye. Because no inflammation was present upon examination, we observed the patient without prescribing any additional medications except for the eye drop treatment for glaucoma...
2016: Journal of Medical Case Reports
Okan Toygar, Michael E Snyder, Christopher D Riemann
PURPOSE: To demonstrate a novel technique for the management of dangling lenses with near complete zonular dehiscence. METHODS: A capsule-sparing combined anterior and posterior surgical approach for dangling lenses with severe zonular dehiscence is described. The surgical record of a patient who underwent phacoemulsification with "dangling lens technique" and in-the-bag intraocular lens (IOL) implantation was evaluated. RESULTS: This technique was able to preserve the lens capsule, allowing freedom of IOL choice and an optimally reconstructed anterior segment...
December 2015: Journal of Refractive Surgery
James A C Oliver, Oliver P Forman, Louise Pettitt, Cathryn S Mellersh
PURPOSE: Mutations in ADAMTS10 (CFA20) have previously been associated with primary open angle glaucoma (POAG) in the Beagle and Norwegian Elkhound. The closely related gene, ADAMTS17, has also been associated with several different ocular phenotypes in multiple breeds of dog, including primary lens luxation and POAG. We investigated ADAMTS17 as a candidate gene for POAG in the Basset Hound and Basset Fauve de Bretagne dog breeds. METHODS: We performed ADAMTS17 exon resequencing in three Basset Hounds and three Basset Fauve de Bretagne dogs with POAG...
2015: PloS One
Gian Maria Cavallini, Veronica Volante, Michele De Maria, Giulio Torlai, Matteo Forlini, Laura Chiesi, Luca Campi, Carlo Cagini
PURPOSE: To demonstrate that in case of absence of capsular support intraocular lens (IOL) scleral fixation is both effective and stable over years. METHODS: A total of 13 eyes from 13 patients who underwent an IOL scleral fixation according to Lewis suturing technique between January 2001 and December 2008 were studied. Patients underwent a complete ophthalmologic evaluation. The IOL stability was assessed using slit-lamp and anterior segment optical coherence tomography (AS-OCT) examination...
November 2015: European Journal of Ophthalmology
Angelo Balestrazzi, Alex Malandrini, Gianluca Martone, Davide Marigliani, Tomaso Caporossi, Gian Marco Tosi
Here we present 2 cases of capsule contraction syndrome (CCS). In both cases, a hydrophilic acrylic Akreos MI60 (Bausch and Lomb) intraocular lens (IOL) was implanted in the capsular bag through microincision cataract surgery, and the literature on the subject is reviewed. Since CCS has been described after the implantation of every IOL type, it is unlikely that the Akreos MI60 chemical and physical properties may cause CCS. When CCS occurs with IOLs composed of increasingly flexible materials that are inserted through incisions of decreasing size, a severe dislocation and deformation of IOL optics and haptics may develop...
September 2014: Case Reports in Ophthalmology
Dhivya Ashok Kumar, Amar Agarwal, Athiya Agarwal, Radhika Chandrasekar
PURPOSE: To analyze the indications, visual outcome, mental status, and quality of life after glued transscleral fixated intraocular lens (IOL) in functionally one-eyed individuals. SETTING: Dr Agarwal's Eye Hospital and Eye Research Centre, Chennai, India. DESIGN: Prospective observational comparative case series. METHODS: Patients with one functioning eye with surgical indications (aphakia, luxated IOL, or dislocated lens) and the fellow eye with no perception of light were included...
July 2014: Eye & Contact Lens
H Häberle, S Schiedel, D-T Pham
BACKGROUND: Absence of capsular support or extended zonulolysis is today the main indication for retroiridal enclavation of the unfoldable PMMA iris claw lens (Verisyse®/Artisan®) if there is sufficient iris support. Contraindications are uveitis or ischaemic retinopathies. PATIENTS AND METHODS: 'In-the-bag' IOL dislocation due to PEX zonulopathy usually occurring 8 years after phacoemulsification is the main indication. For complicated phacoemulsification with extended zonular defect the retroiridal iris claw lens (Verisyse®/Artisan®) has become the stand-by IOL of first choice...
October 2014: Klinische Monatsblätter Für Augenheilkunde
G V Voronin, V R Mamikonian, S I Kharlap, N A Mashkova
A clinical case of bilateral retropupillary implantation of iris-fixated lenses (Worst iris-claw intraocular lenses) in a patient with bilateral complete native lens dislocation into the vitreous body is presented. Despite native lens in the vitreous, the patient did not develop ocular hypertension in either eye after the surgery during a long-term follow-up period. Visual acuity significantly improved and there was no necessity in removing the dislocated lenses.
July 2014: Vestnik Oftalmologii
O F Wadsworth
No abstract text is available yet for this article.
1885: Transactions of the American Ophthalmological Society
Roland Backhaus, Gerhard Schuierer, Christoph Röhrer, M Andreea Gamulescu, Horst Helbig, Ulrich Bogdahn, Felix Schlachetzki
No abstract text is available yet for this article.
May 2015: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
I Schmidt, A Langenbucher, S Moussa, F Schirra, B Seitz, T Eppig
BACKGROUND: Evaluation of refractive predictability with retroiridal implantation of a Verisyse(TM) iris-claw lens (AMO) and optimization of the IOL-constants recommended by the manufacturer. PATIENTS AND METHODS: A retrospective study after retroiridal iris-claw lens implantation in the years 2007-2012 including 52 eyes of 50 patients with a lack of capsular support was carried out. Follow-up data was recorded on average 5 weeks after surgery. Demographic data, indications, accompanying diseases, biometrical data and refractive outcome were analysed and an individualization of the intraocular lens constants for the SRK/T-, Holladay-1, Hoffer-Q and Haigis-formula was carried out...
March 2015: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Nancy Johnstone McLean, Ralph Zimmerman
An adult, female, captive, Matshchie's tree kangaroo was diagnosed with an anterior lens luxation in the right eye and a lens subluxation in the left eye. Both eyes were treated surgically with intracapsular lens extractions. A 360° rhegmatogenous retinal detachment was diagnosed 6 months postoperatively in the left eye. Aphakic vision was maintained in the right eye 9 months postoperatively. Based on family history and the lack of antecedent ocular disease, the lens luxations were presumed to be inherited and veterinarians should be aware of this condition within the captive tree kangaroo population...
January 2015: Veterinary Ophthalmology
Tadashi Inoue, Tetsuya Ohbayashi, Yusuke Fujikawa, Hideyuki Yoshida, Tomoya O Akama, Kazuo Noda, Masahito Horiguchi, Katsuro Kameyama, Yoshio Hata, Kanji Takahashi, Kenji Kusumoto, Tomoyuki Nakamura
Latent TGF-β-binding protein-2 (LTBP-2) is an extracellular matrix protein associated with microfibrils. Homozygous mutations in LTBP2 have been found in humans with genetic eye diseases such as congenital glaucoma and microspherophakia, indicating a critical role of the protein in eye development, although the function of LTBP-2 in vivo has not been well understood. In this study, we explore the in vivo function of LTBP-2 by generating Ltbp2(-/-) mice. Ltbp2(-/-) mice survived to adulthood but developed lens luxation caused by compromised ciliary zonule formation without a typical phenotype related to glaucoma, suggesting that LTBP-2 deficiency primarily causes lens dislocation but not glaucoma...
November 1, 2014: Human Molecular Genetics
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