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https://www.readbyqxmd.com/read/28211878/pre-descemets-endothelial-keratoplasty-the-pdek-clamp-for-successful-pdek
#1
H S Dua, D G Said
PurposeTo design and produce a clamp that enables good handling of donor sclera-corneal disks, allows air to be injected in the corneal stroma and consistently provides pre-Descemets endothelial keratoplasty (PDEK) tissue by creation of a type-1 big bubble (BB) avoiding a type-2BB by shutting the fenestrations in the periphery of the pre-Descemets layer and preventing escape of air.Patients and methodsA clamp with spring loaded handles attached to two rings of 9 mm diameter and 1 mm width with a side port for insertion of a needle for air injection was designed and produced...
February 17, 2017: Eye
https://www.readbyqxmd.com/read/28186681/skin-derived-precursors-as-a-source-of-progenitors-for-corneal-endothelial-regeneration
#2
Emi Inagaki, Shin Hatou, Kazunari Higa, Satoru Yoshida, Shinsuke Shibata, Hideyuki Okano, Kazuo Tsubota, Shigeto Shimmura
Corneal blindness is the fourth leading cause of blindness in the world. Current treatment is allogenic corneal transplantation, which is limited by shortage of donors and immunological rejection. Skin-derived precursors (SKPs) are postnatal stem cells, which are self-renewing, multipotent precursors that can be isolated and expanded from the dermis. Facial skin may therefore be an accessible autologous source of neural crest derived cells. SKPs were isolated from facial skin of Wnt1-Cre/Floxed EGFP mouse. After inducing differentiation with medium containing retinoic acid and GSK 3-β inhibitor, SKPs formed polygonal corneal endothelial-like cells (sTECE)...
February 6, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28179383/cultivated-limbal-epithelial-transplantation-and-penetrating-keratoplasty-postchemical-injury-a-14-year-follow-up
#3
Ritu Shah, Charuta Puranik, Ashik Mohamed, Virender S Sangwan
An 11-year-old girl presented to our tertiary eye care centre with a 9-month-old history of lime injury in the left eye in 1999 with vision of counting fingers close to the face. She initially underwent superficial keratectomy with amniotic membrane graft in 1999. Subsequently, cultivated limbal epithelial transplantation was performed in 2001 which improved her vision to 20/400. Following development of pannus and symblepharon in the left eye, she underwent pannus resection and conjunctival limbal autograft in 2002 and, a month later, optical penetrating keratoplasty (PK) following which her vision improved to 20/125...
February 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28169512/nurses-can-play-an-active-role-in-the-early-diagnosis-of-exposure-keratopathy-in-intensive-care-patients
#4
Elem Kocaçal Güler, İsmet Eşer, Sait Eğrilmez
AIM: This study was conducted in order to determine nurses' ability to diagnose exposure keratopathy reliably in the early stage in intensive care patients. METHODS: This methodological and descriptive study was carried out between 2011 and 2012 in the Neurology and Anesthesiology and Reanimation Intensive Care Units of a teaching hospital in western Turkey. The sample consisted of 4354 ocular assessments in 156 corneas of 78 patients. A patient identification form and a fluorescein test patient tracking chart were used in the data collection...
February 7, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28160068/descemet-membrane-endothelial-keratoplasty-for-graft-failure-following-penetrating-keratoplasty
#5
Sonja Heinzelmann, Daniel Böhringer, Philipp Eberwein, Thabo Lapp, Thomas Reinhard, Philip Maier
PURPOSE: Descemet membrane endothelial keratoplasty (DMEK) is superior to penetrating keratoplasty (PK) in terms of visual rehabilitation, intraoperative safety and risk of rejection. Therefore, it seems reasonable to perform DMEK in eyes with endothelial failure following PK. We herein report our first clinical results. METHODS: Nineteen eyes with endothelial graft failure following PK were treated with DMEK. The majority of these eyes (12) had limited visual potential...
February 3, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28135750/-ophthalmic-plastic-surgery-of-exposure-keratopathy-in-the-intensive-care-unit
#6
C Siebert, A Menges, F H Tost
Critically ill patients in the intensive care unit (ICU) may develop eye problems, due to impaired ocular protective mechanisms or direct involvement of the eye in severe systemic diseases. If eye infections or ocular surface disorders are not identified in time, endophthalmitis or corneal ulcer may develop and can cause permanent functional injuries of the eye. A retrospective analysis was performed and a total of 283 complete intensive care courses of treatment were evaluated, taking into account ophthalmic medical consultations for frequent cardinal symptoms...
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28129295/asymptomatic-infection-in-decompensated-full-thickness-corneal-grafts-referred-for-repeat-penetrating-keratoplasty
#7
Yoav Nahum, Pia Leon, Benedetta Azzurra Ricci-Filipovic, Davide Camposampiero, Diego Ponzin, Massimo Busin
PURPOSE: We report a case series of asymptomatic infections affecting failed corneal grafts in patients referred for repeat penetrating keratoplasty (PK). METHODS: In this retrospective, noncomparative, interventional case series, we reviewed the medical records of all repeat PK procedures performed at Villa Serena-Villa Igea private Hospitals (Forlì, Italy) between January 2011 and March 2016. Specifically, preoperative and postoperative slit-lamp examinations, and the results of histological and bacteriological examinations, were noted...
January 26, 2017: Cornea
https://www.readbyqxmd.com/read/28100180/extensive-bilateral-corneal-edema-6%C3%A2-weeks-after-cataract-surgery-keratopathy-due-to-asclepias-physocarpa-a-case-report
#8
Kazuki Matsuura, Shiro Hatta, Yuki Terasaka, Yoshitsugu Inoue
BACKGROUND: Surgeons may be unaware of the ability of plant toxins to cause corneal damage. Therefore, corneal damage following intraocular surgery due to plant toxins may be misdiagnosed as postoperative infection. CASE PRESENTATION: A 74-year-old man presented with hyperemia and reduced visual acuity in both eyes 6 weeks after uneventful cataract surgery. We observed extensive hyperemia and corneal stromal edema with Descemet's folds in both eyes. After obtaining a detailed patient history, we diagnosed plant toxin-induced corneal edema due to Asclepias physocarpa, which can induce corneal edema by inhibiting the Na(+)/K(+) ATPase activity of the corneal endothelium...
January 18, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28079685/asymmetric-deep-stromal-keratopathy-in-a-patient-with-multiple-myeloma
#9
Laurel T Tainsh, Patrick A Coady, John H Sinard, Natalia Neparidze, Seth W Meskin, Ron A Adelman, Jessica Chow
PURPOSE: To report a case of asymmetric deep stromal keratopathy in a patient with multiple myeloma. METHODS: Case report and literature review. RESULTS: An 85-year-old woman was found to have progressive visually significant left-sided deep stromal opacity in the setting of monoclonal gammopathy. Hematologic workup resulted in a diagnosis of IgG kappa multiple myeloma. Histopathology was significant for semicrystalline deposits in the posterior stroma...
March 2017: Cornea
https://www.readbyqxmd.com/read/28079683/factors-associated-with-graft-detachment-after-primary-descemet-stripping-automated-endothelial-keratoplasty
#10
Yoav Nahum, Pia Leon, Michael Mimouni, Massimo Busin
PURPOSE: To identify risk factors associated with postoperative graft detachment after Descemet stripping automated endothelial keratoplasty (DSAEK). METHODS: In this retrospective institutional cohort study, the study group included all consecutive eyes that underwent primary DSAEK between January 2005 and October 2015 at Villa Serena-Villa Igea private hospitals (Forlì, Italy) and developed postoperative graft detachment (n = 45). The control group included all eyes that underwent primary DSAEK during the same period and did not develop graft detachment (n = 1167)...
March 2017: Cornea
https://www.readbyqxmd.com/read/28060074/eventual-endothelial-failure-after-initial-corneal-clearing-after-a-detached-endothelial-graft-in-fuchs-dystrophy
#11
Hyunjoo J Lee, Wuqaas M Munir
PURPOSE: To report a case of eventual corneal endothelial cell failure after spontaneous resolution of corneal edema after failed Descemet membrane endothelial keratoplasty (DMEK). METHODS: Retrospective case report. RESULTS: A 56-year-old man with Fuchs endothelial corneal dystrophy underwent cataract and DMEK surgery in the left eye. The transplanted DMEK graft detached in the early postoperative period and formed a peripheral scroll. Despite graft detachment, corneal edema resolved with endothelial cell repopulation of the central cornea...
February 2017: Cornea
https://www.readbyqxmd.com/read/28050052/the-hematologic-definition-of-monoclonal-gammopathy-of-undetermined-significance-in-relation-to-paraproteinemic-keratopathy-an-american-ophthalmological-society-thesis
#12
Walter Lisch, Joanna Wasielica-Poslednik, Tero Kivelä, Ursula Schlötzer-Schrehardt, Jens M Rohrbach, Walter Sekundo, Uwe Pleyer, Christina Lisch, Alexander Desuki, Heidi Rossmann, Jayne S Weiss
PURPOSE: To determine if paraproteinemic keratopathy (PPK) in the setting of monoclonal gammopathy of undetermined significance (MGUS) causes distinct patterns of corneal opacification that can be distinguished from hereditary, immunologic, or inflammatory causes. METHODS: A retrospective, interventional study of patients showed distinct bilateral opacity patterns of the cornea at the eye clinics of Hanau, Mainz, Helsinki, Marburg, and Berlin between 1993 and 2015...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28039348/optical-coherence-tomography-of-band-keratopathy
#13
Ahmad M Mansour, Randa Haddad
No abstract text is available yet for this article.
December 30, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/28017678/deep-anterior-lamellar-keratoplasty-after-descemet-stripping-automated-endothelial-keratoplasty
#14
Shay Gutfreund, Pia Leon, Shmuel Graffi, Massimo Busin
PURPOSE: To report the indications and long-term outcomes of deep anterior lamellar keratoplasty (DALK) performed after Descemet stripping automated endothelial keratoplasty (DSAEK) in cases of visually significant stromal opacities. DESIGN: Retrospective, interventional, consecutive case series. METHOD: Setting: Private hospital. Study populationThirteen eyes that underwent DALK after DSAEK at our Institution. Indications for DALK after DSAEK included both stromal opacities persisting after DSAEK and stromal opacities occurring secondarily in post-DSAEK corneas...
December 22, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28002113/techniques-for-learning-descemet-membrane-endothelial-keratoplasty-for-eyes-of-asian-patients-with-shallow-anterior-chamber
#15
Takahiko Hayashi, Itaru Oyakawa, Naoko Kato
PURPOSE: To describe several essential surgical techniques that overcome difficulties in performing Descemet membrane endothelial keratoplasty (DMEK) for inexperienced surgeons, especially those who perform DMEK on eyes of Asian patients. METHODS: Nine eyes of 9 Asian patients with bullous keratopathy who underwent DMEK were analyzed retrospectively. All patients were given a diuretic such as D-mannitol or acetazolamide shortly before surgery, with retrobulbar anesthesia and a Nadbath facial nerve block...
March 2017: Cornea
https://www.readbyqxmd.com/read/27994806/descemet-stripping-automated-endothelial-keratoplasty-in-fuchs-endothelial-dystrophy-versus-pseudophakic-bullous-keratopathy
#16
Mohammad Ali Javadi, Sepehr Feizi, Roya Jafari, Firooz Mirbabaee, Vahid Ownagh
PURPOSE: To compare clinical and confocal scan outcomes after Descemet stripping automated endothelial keratoplasty (DSAEK) performed for Fuchs' endothelial dystrophy (FED) versus pseudophakic bullous keratopathy (PBK). METHODS: This retrospective comparative study included 47 consecutive eyes of 39 patients with the diagnosis of FED (n = 29, group 1) or PBK (n = 18, group 2) that underwent DSAEK. Clinical outcomes were compared between the study groups. At the final follow-up examination, confocal microscopy was used to measure and compare central corneal and graft thickness as well as endothelial cell density and morphology between the two groups...
October 2016: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/27980363/comparison-of-long-term-clinical-outcomes-between-descemet-s-stripping-automated-endothelial-keratoplasty-and-penetrating-keratoplasty-in-patients-with-bullous-keratopathy
#17
Sung Eun Kim, Sung A Lim, Yong-Soo Byun, Choun-Ki Joo
PURPOSE: To compare 2-year clinical outcomes of Descemet's stripping automated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) in patients with bullous keratopathy. METHODS: A retrospective chart review was performed to obtain 2 years of follow-up data of DSAEK or PK at a single center from March 2009 to September 2012. The study comprised 15 eyes of DSAEK and 11 eyes of PK. Outcome measures included best-corrected visual acuity (BCVA), spherical and keratometric changes, central corneal thickness, endothelial cell density, intraocular pressure, and postoperative complications...
December 2016: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/27978558/nerve-growth-factor-attenuates-apoptosis-and-inflammation-in-the-diabetic-cornea
#18
Jin Hyoung Park, Soon-Suk Kang, Jae Yong Kim, Hungwon Tchah
Purpose: To examine the effects of nerve growth factor (NGF) on apoptosis and inflammation in the diabetic cornea. Methods: To investigate the effects of NGF on glucose-induced apoptosis, we stained human corneal epithelial cells (HCECs) for annexin-V and propidium iodide (PI), and measured expression of cleaved caspase-3 and the Bcl-2-associated X protein (BAX). Moreover, to examine the effects of NGF on inflammation, we quantified the expression of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) using multiplex cytokine analysis, and analyzed nuclear factor-κB (NF-κB) activation and NF-κ-B inhibitor α (IκBα) degradation using Western blot analysis...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27965261/very-early-endothelial-cell-loss-after-penetrating-keratoplasty-with-organ-cultured-corneas
#19
Anne Sophie Gauthier, Thibaud Garcin, Gilles Thuret, Zhiguo He, Remy Jullienne, Marie Caroline Trone, Chaker Nefzaoui, Sophie Acquart, Fabien Forest, Michel Péoc'h, Bernard Delbosc, Philippe Gain
AIMS: After keratoplasty, postoperative endothelial cell loss is calculated between the eye bank endothelial cell density (ebECD) and the postoperative specular microscopy (SM). To elucidate the very early cell loss, always described after penetrating keratoplasty (PK), we designed two complementary studies. METHODS: (1) Clinical prospective study of 90 consecutive PKs (keratoconus, Fuchs' corneal dystrophy, lattice dystrophy, bullous keratopathy) with organ-cultured corneas and postoperative follow-up by SM at day 5 (D5), D15, month 1 (M1) and M3...
December 13, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27935054/damaging-effects-of-ultraviolet-radiation-on-the-cornea
#20
Naomi C Delic, J Guy Lyons, Nick Di Girolamo, Gary M Halliday
The cornea sits at the anterior aspect of the eye and additionally to the skin, is highly exposed to ultraviolet radiation (UVR). The cornea blocks a significant proportion of UVB from reaching the posterior structures of the eye. However, UVA can penetrate the full thickness of the cornea, even reaching the anterior portion of the lens. Epidemiological data indicate that UVR is a contributing factor for a multitude of corneal diseases of the cornea including pterygium, photokeratitis, climatic droplet keratopathy, (CDK) and ocular surface squamous neoplasia (OSSN), although the pathogenic mechanisms of each require further elucidation...
December 9, 2016: Photochemistry and Photobiology
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