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https://www.readbyqxmd.com/read/28698011/clinical-and-morphological-manifestations-of-aniridia-associated-keratopathy-on-anterior-segment-optical-coherence-tomography-and-in-vivo-confocal-microscopy
#1
Anna Voskresenskaya, Nadezhda Pozdeyeva, Tatyana Vasilyeva, Yevgeniy Batkov, Aleksandr Shipunov, Boris Gagloev, Rena Zinchenko
PURPOSE: The study aimed to evaluate clinical and morphological changes in the limbal palisades of Vogt (POV) at different stages of aniridia-associated keratopathy (AAK) and to assess possible utility of anterior segment optical coherence tomography (AS-OCT) for the visualization of limbal progenitor structures as it correlates to laser scanning confocal microscopy (LSCM) data. METHODS: The study involved 32 patients (59 eyes) with congenital aniridia. AAK stage was defined based on biomicroscopy...
July 8, 2017: Ocular Surface
https://www.readbyqxmd.com/read/28688026/indications-and-graft-survival-analysis-in-optical-penetrating-keratoplasty-in-a-tertiary-care-center-in-north-india-a-5-year-study
#2
Sudesh Kumar Arya, Amit Raj, Ravi Kant Bamotra, Anubha Bhatti, Jyoti Deswal, Meenakshi Sindhu
PURPOSE: To study the indications and variables correlating with graft survival in optical penetrating keratoplasty in a tertiary care hospital in north India. PARTICIPANTS: All patients who underwent optical keratoplasty, except those undergoing lamellar grafts, tectonic grafts transplants and penetrating keratoplasty done for therapeutic purposes were included in the study. Patients with follow-up less than 2 years were excluded from the study. MATERIALS AND METHODS: Data were obtained by reviewing the records of 101 patients who underwent optical penetrating keratoplasty from 2008 to 2013 for various indications...
July 7, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28660094/aqueous-deficient-dry-eye-syndrome-post-orbital-radiotherapy-a-10-year-retrospective-study
#3
Shubha Tiwari, Anusha Bhatt, Jayalaxmi Nagamodi, Mohammad Javed Ali, Hasnat Ali, Milind N Naik, Vijay Anand P Reddy, Geeta K Vemuganti
PURPOSE: Despite advances in orbital radiotherapy (XRT), a significant proportion of patients develop ophthalmic complication like dry eye syndrome (DES). The study evaluates the prevalence of aqueous deficient DES (ADDE) and lacrimal gland (LG) changes through histologic evaluation and ex-vivo expansion potential postorbital XRT. METHODS: With the approval of the institutional review board, medical records of patients who underwent orbital XRT as management protocol were reviewed for evidence of ADDE using DEWS (Dry Eye Workshop) 2007 criteria (n = 51)...
June 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28658822/recurrent-optic-nerve-pilocytic-astrocytoma-a-rare-case
#4
Sudha Girish Menon, Vuppalapati Nishant Janardhana Raju, Sulatha V Bhandary, Krishna Rao Addoor
Pilocytic astrocytoma is a low grade glioma that affects mostly children and young adults and can occur anywhere in the central nervous system. Pilocytic astrocytoma of the optic nerve is an equally indolent subtype that is often associated with Neurofibromatosis Type I (NFI). A 40-year-old male presented with left sided axial proptosis and exposure keratopathy. MRI revealed a mass in left proximal orbit, extending posteriorly abutting the chiasma and the right optic nerve on MRI. Enucleation of the left eye along with near total excision of intracranial part of the mass was performed...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28652692/combined-30-degree-bevel-up-and-down-technique-against-0-degree-phaco-tip-for-phacoemulsification-surgery-of-hard-cataracts
#5
Rajesh Subhash Joshi, Sonal Jayant Muley
PURPOSE: To evaluate the effective phaco time (EPT), cumulative dissipated energy (CDE) and nucleus emulsification time (NET) as phaco parameters with 0- and 30-degree phaco tip. PATIENTS AND METHODS: This prospective, interventional and observational case series included 294 patients scheduled for cataract removal by phacoemulsification technique. Patients with nuclear cataracts of grade 4 and 5 nuclear opalescence of Lens Opacities Classification System III were included in the study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28648760/corneal-endothelial-cells-activate-innate-and-acquired-arm-of-anti-viral-responses-after-cytomegalovirus-infection
#6
Dai Miyazaki, Ryu Uotani, Michiko Inoue, Tomoko Haruki, Yumiko Shimizu, Keiko Yakura, Satoru Yamagami, Tatsuo Suzutani, Mayumi Hosogai, Hiroki Isomura, Yoshitsugu Inoue
Infection of the corneal endothelial cells by human cytomegalovirus (CMV) is an important cause of corneal endotheliitis. CMV endotheliitis is difficult to completely cure and relapses are frequent. This can cause blinding corneal bullous keratopathy. However, the pathogenesis of CMV endotheliitis remains undetermined. To understand the immunopathology of endotheliitis, we examined how corneal endothelial cells prime the anti-viral immunity after CMV infection based on global transcriptional responses. To accomplish this, human corneal endothelial (HCEn) cells were infected with CMV, and the global transcriptional responses were determined by microarray analyses for primary anti-viral responses using network analysis...
June 23, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28644235/chandelier-illumination-for-descemet-membrane-endothelial-keratoplasty
#7
Toshiki Shimizu, Takahiko Hayashi, Kentaro Yuda, Ayako Tsuchiya, Itaru Oyakawa, Nobuhisa Mizuki, Naoko Kato
PURPOSE: To describe a simple technique that uses posterior chandelier illumination during Descemet membrane endothelial keratoplasty in cases of severe bullous keratopathy (BK). METHODS: Five eyes of 4 patients with advanced BK undergoing Descemet membrane endothelial keratoplasty were retrospectively analyzed. The pupil of the host eye was not treated with mydriatic or miotic agents. The chandelier illuminator was inserted transconjunctivally into the vitreous cavity from the pars plana...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28626820/factors-associated-with-surface-epithelial-keratopathy-after-optical-penetrating-keratoplasty
#8
Anuradha Raj, Renu Dhasmana, Harsh Bahadur
PURPOSE: The aim of the study was to evaluate the various donor and recipient factors associated with short-term prevalence of surface epithelial keratopathy after optical penetrating keratoplasty (OPK). METHODS: Preoperative and postoperative data of 91 eyes of 91 patients were reviewed retrospectively who had undergone OPK from March 2013 to February 2016. Donor and recipient data were analyzed for age and sex of the donor, cause of death, death to enucleation time (DET), death to preservation time (DPT), enucleation to utilisation time (EUT) and total time (TT), age and sex of recipient, indications of penetrating keratoplasty (PK), associated glaucoma and recipient size (RS)...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28623164/thick-corneas-large-pupils-and-a-giant-problem
#9
Francesco Pellegrini, Giovanni Prosdocimo, Daniela Bonsanto, Rod Foroozan
An 87-year-old woman presented 1 month after uneventful cataract surgery with ipsilateral corneal edema. She was diagnosed with pseudophakic bullous keratopathy and scheduled for endothelial transplantation. However, a few days later, she presented with bilateral corneal edema, dilated pupils and further reduction of visual acuity. Neuro-Ophthalmic evaluation disclosed a bilateral ocular ischemic syndrome causing complete visual loss. Temporal artery biopsy was consistent with GCA. Corneal decompensation should be considered as a rare presentation of GCA, that ophthalmologists should suspect in any case of unilateral or bilateral ocular ischemic syndrome...
June 13, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28622309/eyelid-and-fornix-reconstruction-in-abortive-cryptophthalmos-a-single-center-experience-over-12-years
#10
J Ding, Z Hou, Y Li, N Lu, D Li
PurposeAbortive cryptophthalmos is a rare congenital eyelid anomaly with poor prognosis for vision and cosmesis. The study aims to present its varied manifestations and surgical outcomes.Patients and methodsThe medical records of patients with abortive cryptophthalmos treated at the Oculoplastic Clinic of Beijing Tongren Hospital between January 2004 and May 2016 were reviewed. Early surgical intervention was performed when exposure keratopathy occurs. Upper eyelid and superior fornix were mainly reconstructed with sliding myocutaneous flap and scleral and amniotic grafts...
June 16, 2017: Eye
https://www.readbyqxmd.com/read/28621916/construction-of-anterior-hemi-corneal-equivalents-using-nontransfected-human-corneal-cells-and-transplantation-in-dog-models
#11
Bin Xu, Zhan Song, Tingjun Fan
Tissue-engineered human anterior hemi-cornea (TE-aHC) is a promising equivalent for treating anterior lamellar keratopathy to surmount the severe shortage of donated corneas. This study was intended to construct a functional TE-aHC with nontransfected human corneal stromal (ntHCS) and epithelial (ntHCEP) cells using acellular porcine corneal stromata (aPCS) as a carrier scaffold, and evaluate its biological functions in a dog model. To construct a TE-aHC, ntHCS cells were injected into an aPCS scaffold and cultured for 3 days; then, ntHCEP cells were inoculated onto the Bowman's membrane of the scaffold and cultured for 5 days under air-liquid interface condition...
June 16, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28619977/infectious-crystalline-keratopathy-after-descemet%C3%A3-%C3%A2-%C3%A2-s-stripping-endothelial-keratoplasty
#12
Ashley J Porter, Graham A Lee, Kevin Whitehead
A 68-year-old woman presented with infectious crystalline keratopathy 4 months after she underwent a combined phacoemulsification and Descemet's stripping endothelial keratoplasty for Fuch's endothelial dystrophy in her left eye. After 5 months of topical moxifloxacin 1%, the infiltrate responded well but had not completely resolved, with the resulting endothelial failure requiring a penetrating keratoplasty 9 months after the initial operation. Microbiology identified Enterococcus faecalis with the histopathology demonstrating bacterial colonies within the graft interface...
June 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28614157/probable-donor-derived-cytomegalovirus-disease-after-keratolimbal-allograft-transplantation
#13
Albert Y Cheung, Amit Govil, Scott R Friedstrom, Edward J Holland
PURPOSE: To report a case of probable donor-derived cytomegalovirus (CMV) infection after keratolimbal allograft (KLAL) transplantation. METHODS: Observational case report. RESULTS: A 41-year-old man with a history of aniridic keratopathy and limbal stem cell deficiency underwent KLAL in his right eye. Preoperatively, he was negative for CMV IgG and IgM. Postoperatively, he was maintained on tacrolimus and mycophenolate mofetil for systemic immunosuppression; he was also on prophylactic valganciclovir (for CMV) and trimethoprim/sulfamethoxazole (for pneumocystis pneumonia) for 1 month...
August 2017: Cornea
https://www.readbyqxmd.com/read/28606270/-keratoplasty-classification-and-primary-disease-spectrum-analysis-of-315-cases
#14
S B Cai, M Sun, S Li, L J Xu, W Wang, J Wang, W K Hu, X Y Li, P Wang, H Zhang, G G Li
Objective: To identify the primary disease spectrum and trends of surgical procedure of keratoplasty patients. Methods: Retrospective case series study. To review all patients who underwent keratoplasty at Department of ophthalmology in Tongji Hospital from January 1, 2012 to December 31, 2015. The data collected included age, sex, birthplace, and primary corneal disease and associated surgical procedures. Then the data were compared with similar papers domestic and foreign. Results: A total of 315 keratoplasties were performed during this 4-year period...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28602432/neurotrophic-keratopathy-in-a-patient-with-familial-amyloidosis
#15
A M de Carvalho Mendes Castenheira, P Pujol Vives, M Asaad Ammaar
INTRODUCTION: Familial amyloidotic polyneuropathy is a disease related to amyloid material deposits in the extracellular matrix that can affect many tissues, including the eye. CASE REPORT: This case includes clinical data, a full corneal study report, and histopathological findings, as well as the treatment and follow up of bilateral neurotrophic keratopathy in a 33 year-old patient with familial amyloidotic polyneuropathy. DISCUSSION: Although amyloidotic deposits were also found in the conjunctival tissue, this is not a typical form of ophthalmic amyloidosis...
June 8, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28601910/the-clinical-outcomes-of-surgical-management-of-anterior-chamber-migration-of-a-dexamethasone-implant-ozurdex%C3%A2
#16
Hyunseung Kang, Min Woo Lee, Suk Ho Byeon, Hyoung Jun Koh, Sung Chul Lee, Min Kim
PURPOSE: Our purpose was to describe the clinical course, and individualized management approaches, of patients with migration of a dexamethasone implant into the anterior chamber. METHODS: This was a retrospective review of four patients with seven episodes of anterior chamber migration of a dexamethasone implant. RESULTS: After 924 intravitreal dexamethasone injections, anterior migration of the implant occurred in four eyes of four patients (0...
June 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28592408/recovery-of-corneal-sensitivity-and-increase-in-nerve-density-and-wound-healing-in-diabetic-mice-after-pedf-plus-dha-treatment
#17
Jiucheng He, Thang Luong Pham, Azucena Kakazu, Haydee E P Bazan
Diabetic keratopathy decreases corneal sensation and tear secretion, and delays wound healing after injury. In the current study, we tested the effect of treatment with pigment epithelium-derived factor (PEDF) in combination with docosahexaenoic acid (DHA) on corneal nerve regeneration in a mouse model of diabetes with or without corneal injury. The study was performed in streptozotocin (STZ)-induced diabetic mice (C57BL/6). Ten weeks after STZ injection, diabetic mice showed significant decreases of corneal sensitivity, tear production and epithelial subbasal nerve density when compared with age-matched normal mice...
June 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28574137/iris-reconstruction-using-artificial-iris-prosthesis-for-management-of-aniridia
#18
Yehia S Mostafa, Amr A Osman, Dina H Hassanein, Ashraf M Zeid, Ahmed M Sherif
PURPOSE: To discuss the limitations and benefits of the BrightOcular prosthetic artificial iris device in management of aniridia associated with aphakia or cataract. METHODS: This is a retrospective study including 5 eyes of 4 patients who underwent implantation of the BrightOcular iris prosthesis (Stellar Devices) for total or partial aniridia. The cases included 2 eyes of 1 patient with congenital aniridia associated with congenital cataract and 3 eyes with traumatic aniridia: 1 with subluxated cataractous lens and 2 with aphakia...
May 27, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28571179/cow-urine-keratopathy-a-case-report
#19
Sumeet Khanduja, Prachi Jain, Sumit Sachdeva, Jitender Phogat
Injury to the ocular surface has been described to occur with a wide variety of chemicals. In most cases the cause is industrial injury with acids or alkalis. We are reporting a case of ocular surface injury due to "Cow urine" which to the best of our knowledge is been reported for the first time. Cow urine is a well-accepted medicinal ingredient in ancient Indian medicine. However, wrong formulation and inadvertent prescriptions by quacks can lead to severe ocular surface injury and morbidity. Here, with this case report we have discussed the possible culprit and possible mechanism of ocular injury due to instillation of a concoction containing cow urine as an active ingredient and also discuss legal aspects of quackery in India...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28571054/ocular-exposure-to-paraquat-resulting-in-keratopathy-pseudomembranous-conjunctivitis-and-symblepharon
#20
Benjamin R LaHood, Neil Avery, Albert Covello, Daniel Allbon
No abstract text is available yet for this article.
June 2, 2017: New Zealand Medical Journal
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