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Keratoconjunctivitis sicca

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https://www.readbyqxmd.com/read/28207432/spontaneous-canalicular-plug-erosion-after-punctal-plug-placement
#1
Xinxin Zhang, Maya Bitar, Richard M Davis
PURPOSE: To describe a case of keratoconjunctivitis sicca treated with punctal plug placement with the first reported complication of subsequent plug erosion through the canaliculus and extrusion through the lid. METHODS: Punctal plugs were placed in a patient with Sjogren syndrome for treatment of keratoconjunctivitis sicca. More than 12 years later, the plug was noted to have eroded through the canaliculus and extruded through the conjunctiva and lid. RESULTS: The extruded plug was removed, and punctal cautery was performed on 2 other puncta with improved symptom control...
February 15, 2017: Cornea
https://www.readbyqxmd.com/read/28107078/measurement-of-tear-production-and-intraocular-pressure-in-healthy-captive-helmeted-guinea-fowl-numida-meleagris
#2
Seyed Mehdi Rajaei, Maneli Ansari Mood, Seyed Sohail Ghazanfari Hashemi Dvm
We establish reference values of tear production by the phenol red thread test (PRTT) and intraocular pressure (IOP) by rebound tonometry in helmeted guinea fowl ( Numida meleagris ). Aqueous tear production and IOP were measured in 44 (22 males, 22 females) clinically normal captive helmeted guinea fowl. Birds were gently physically restrained in the sitting position without any pressure to the head or neck. In each bird, aqueous tear production was measured by placing phenol red threads in the superior conjunctival fornix, and IOP was measured by using a Tonovet rebound tonometer...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28003932/allogeneic-mesenchymal-stem-cell-transplantation-in-dogs-with-keratoconjunctivitis-sicca
#3
Maura K W Bittencourt, Michele A Barros, João Flávio P Martins, Jose Paulo C Vasconcellos, Bruna P Morais, Celine Pompeia, Matheus Domingues Bittencourt, Karine Dos Santos Evangelho, Irina Kerkis, Cristiane V Wenceslau
Keratoconjunctivitis sicca (KCS) is a dysfunction in tear production associated with clinical signs, which include conjunctival hyperemia, ocular discharge, discomfort, pain, and, eventually, corneal vascularization and pigmentation. Immunosuppressive drugs are routinely administrated for long periods to treat KCS but with side effects and limited results. Evaluation of the clinical benefits of intralacrimal transplantation of allogeneic mesenchymal stem cells (MSCs) in dogs with mild-moderate and severe KCS was done...
December 3, 2016: Cell Medicine
https://www.readbyqxmd.com/read/27919262/erratum-to-clinical-evaluation-of-a-nutraceutical-diet-as-an-adjuvant-to-pharmacological-treatment-in-dogs-affected-by-keratoconjunctivitis-sicca
#4
Simona Destefanis, Daniela Giretto, Maria Cristina Muscolo, Alessandro Di Cerbo, Gianandrea Guidetti, Sergio Canello, Angela Giovazzino, Sara Centenaro, Giuseppe Terrazzano
No abstract text is available yet for this article.
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27911424/-effectiveness-of-soft-contact-lenses-in-severe-keratoconjunctivitis-sicca-treated-with-local-immunosuppressive-therapy
#5
T N Safonova, O V Gladkova, V I Boev, A A Fedorov
AIM: To study the effectiveness of soft contact lenses in severe keratoconjunctivitis sicca (KCS) treated with local immunosuppressive therapy. MATERIAL AND METHODS: We have examined 41 patients (60 eyes) with severe KCS, including 3 men (4 eyes) and 38 women (56 eyes) aged from 27 to 76 years. Group 1 consisted of 22 persons (30 eyes) who were prescribed cyclosporine А 0.05% instillations 2 times daily, artificial tears, and soft contact lenses. Group 2 consisted of 19 patients (30 eyes) who received instillations of cyclosporine А 0...
2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27831536/bilateral-chorioretinopathy-in-child-onset-systemic-lupus-erythematosus
#6
W G G Fischer, T O Kaé, R de Almeida, U L de Oliveira Filho, M A P Vilela, D B Araujo
Any of the various layers of the eye may suffer injury in systemic lupus erythematosus, ranging from keratoconjunctivitis sicca to retinopathy and optic neuritis. Rheumatologists must always be aware of ocular involvement in those patients since rapid diagnosis and a prompt intervention in those severe cases can prevent visual loss or even irreversible blindness. We present here the case of a 14-year-old girl who, despite a short period of disease, developed chorioretinopathy with transitory visual impairment with a good treatment response...
November 9, 2016: Lupus
https://www.readbyqxmd.com/read/27791390/immediate-effect-of-3-diquafosol-ophthalmic-solution-on-tear-muc5ac-concentration-and-corneal-wetting-ability-in-normal-and-experimental-keratoconjunctivitis-sicca-rat-models
#7
Kwang-Eon Choi, Jong-Suk Song, Boram Kang, Youngsub Eom, Hyo-Myung Kim
PURPOSE: To evaluate the immediate effect of 3% diquafosol ophthalmic solution on tear MUC5AC concentration, periodic acid-Schiff (PAS)-positive goblet cells, and tear film stability in normal and keratoconjunctivitis sicca (KCS) rat models. METHODS: Rats were divided into normal and KCS groups. 3% of diquafosol solution was instilled into the right eye and normal saline into the left eye in both groups. To determine the peak time of tear MUC5AC concentration, tears were collected after 3% diquafosol instillation every 5 min up to 20 min...
October 28, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27761982/assessment-of-tear-film-osmolarity-using-the-tearlab-%C3%A2-osmometer-in-normal-dogs-and-dogs-with-keratoconjunctivitis-sicca
#8
Lionel Sebbag, Shin Ae Park, Philip H Kass, David J Maggs, Mayssa Attar, Christopher J Murphy
OBJECTIVE: To evaluate repeatability and reproducibility of tear osmolarity measured using the TearLab(™) osmometer in normal dogs and to assess its diagnostic potential in dogs with keratoconjunctivitis sicca (KCS). ANIMALS STUDIED: Beagle dogs; six normal and five with KCS. PROCEDURES: Tear osmolarity and Schirmer tear test-1 (STT-1) values were obtained at various times. Normal dogs were assessed for diurnal variation and repeatability and reproducibility of measurements...
October 20, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27726460/boston-type-i-keratoprosthesis-implantation-following-autologous-submandibular-gland-transplantation-for-end-stage-ocular-surface-disorders
#9
Jianjun Gu, Jiajie Zhai, Guiqing Liao, Jiaqi Chen
PURPOSE: To describe the results of Boston keratoprosthesis implantation in a patient with Stevens-Johnson syndrome following autologous submandibular gland transplantation. DESIGN: Observational case report. METHODS: We report the case of a man diagnosed with Stevens-Johnson syndrome. Autologous submandibular gland transplantation was performed in the right eye in 2008 to ameliorate tear film deficiency. Due to the improvement in the microenvironment of the ocular surface, Boston keratoprosthesis implantation was performed in the right eye in 2011...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27706128/age-related-spontaneous-lacrimal-keratoconjunctivitis-is-accompanied-by-dysfunctional-t-regulatory-cells
#10
T G Coursey, F Bian, M Zaheer, S C Pflugfelder, E A Volpe, C S de Paiva
In both humans and animal models, the development of Sjögren syndrome (SS) and non-SS keratoconjunctivitis sicca (KCS) increases with age. Here, we investigated the ocular surface and lacrimal gland (LG) phenotype of NOD.B10.H2(b) mice at 7-14, 45-50, and 96-100 weeks. Aged mice develop increased corneal permeability, CD4(+) T-cell infiltration, and conjunctival goblet cell loss. Aged mice have LG atrophy with increased lymphocyte infiltration and inflammatory cytokine levels. An increase in the frequency of CD4(+)Foxp3(+) T regulatory cells (Tregs) was observed with age in the cervical lymph node (CLN), spleen, and LG...
October 5, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27658509/clinical-evaluation-of-a-nutraceutical-diet-as-an-adjuvant-to-pharmacological-treatment-in-dogs-affected-by-keratoconjunctivitis-sicca
#11
Simona Destefanis, Daniela Giretto, Maria Cristina Muscolo, Alessandro Di Cerbo, Gianandrea Guidetti, Sergio Canello, Angela Giovazzino, Sara Centenaro, Giuseppe Terrazzano
BACKGROUND: Canine keratoconjunctivitis sicca (cKCS) is an inflammatory eye condition related to a deficiency in the tear aqueous fraction. Etiopathogenesis of such disease is substantially multifactorial, combining the individual genetic background with environmental factors that contribute to the process of immunological tolerance disruption and, as a consequence, to the emergence of autoimmunity disease. In this occurrence, it is of relevance the role of the physiological immune-dysregulation that results in immune-mediated processes at the basis of cKCS...
September 22, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27591567/improving-the-topical-ocular-pharmacokinetics-of-an-immunosuppressant-agent-with-mucoadhesive-nanoemulsions-formulation-development-in-vitro-and-in-vivo-studies
#12
Sohail Akhter, Mohammed Anwar, Mohammad Ahsan Siddiqui, Iqbal Ahmad, Javed Ahmad, Mohammad Zaki Ahmad, Aseem Bhatnagar, Farhan Jalees Ahmad
Topical ocular conditions such as cornea transplant rejection and keratoconjunctivitis sicca (so called dry eye disease) require therapeutic concentration of immunosuppressant onto the ocular surface for prolonged period. Based on this rational, we optimized cyclosporine A (Cy-A) loaded polymeric mucoadhesive nanoemulsion (Cy-A-mN) with higher Cy-A payload, improved ocular retention, corneal and conjunctival bioavailability. The concentrations of oil, surfactant and co-surfactant needed for the stable nanoemulsion were screened followed by phase behavior study of the formulations components by the construction of pseudo-ternary phase diagrams...
December 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27490054/increased-straylight-in-patients-with-keratoconjunctivitis-sicca
#13
Parul Chawla Gupta, Jagat Ram
No abstract text is available yet for this article.
October 2016: Cornea
https://www.readbyqxmd.com/read/27445067/a-randomized-controlled-study-of-the-efficacy-and-safety-of-a-new-eyedrop-formulation-for-moderate-to-severe-dry-eye-syndrome
#14
Frédéric Chiambaretta, Serge Doan, Marc Labetoulle, Nicolas Rocher, Lamia El Fekih, Riadh Messaoud, Moncef Khairallah, Christophe Baudouin
PURPOSE: This study compared the efficacy and safety of hyaluronic acid (HA)-trehalose, a new eyedrop containing trehalose (a natural bioprotectant) and HA, to an established formulation containing only HA. METHODS: This was a phase III, randomized, active-controlled, investigator-masked, multicenter study in France and Tunisia. In all, 105 adult patients (≥18 years) with moderate to severe dry eye disease (DED) received either HA-trehalose (n = 52) or HA (n = 53) 3-6 times per day for 84 days...
January 19, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/27397988/prevalence-type-and-prognosis-of-ocular-lesions-in-shelter-and-owned-client-dogs-naturally-infected-by-leishmania-infantum
#15
Simona Di Pietro, Valentina Rita Francesca Bosco, Chiara Crinò, Francesco Francaviglia, Elisabetta Giudice
AIM: The point prevalence of ocular lesions due to leishmaniasis was evaluated in 127 dogs living in a municipal shelter placed in a highly endemic area (Sicily, Italy). Moreover, the period prevalence, the type, and prognosis of lesions due to leishmaniasis were evaluated in 132 dogs with ocular pathologies referred to a Veterinary Teaching Hospital (VTH) in the same endemic area over a 3-year period. MATERIALS AND METHODS: All the dogs were submitted to ophthalmological examination...
June 2016: Veterinary World
https://www.readbyqxmd.com/read/27352988/infectious-crystalline-keratopathy-in-dogs-and-cats-clinical-in-vivo-confocal-microscopic-histopathologic-and-microbiologic-features-of-eight-cases
#16
Eric C Ledbetter, Patrick L McDonough, Kay Kim
OBJECTIVE: To describe clinical, in vivo confocal microscopic, histopathologic, and microbiologic features of canine and feline cases of infectious crystalline keratopathy (ICK). ANIMALS STUDIED: Six dogs and two cats with naturally acquired ICK. PROCEDURES: Medical records of dogs and cats with a clinical diagnosis of ICK were reviewed. Signalment, medical history, clinical findings, and diagnostic evaluations were retrieved, including corneal cytology, histopathology, in vivo confocal microscopy, and microbiology results...
June 29, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27296759/dry-eye-disease-present-challenges-in-the-management-and-future-trends
#17
REVIEW
Zahraa Al-Saedi, Allison Zimmerman, Rinda Devi Bachu, Surajit Dey, Zahoor Shah, Reginald Baugh, Sai H S Boddu
Dry eye disease (DED) is a tear film disorder resulting in hyperosmolarity of the tear film and inflammation of the ocular surface. DED is also referred to as keratoconjunctivitis sicca (KCS) and dry eye syndrome. DED represents a significant public health issue, particularly in older adults, and needs more research and attention. Despite the urgent need for safe and effective pharmacotherapies, there is currently only one approved medication, Restasis®, to tackle DED. In this review article, we present an overview of DED, classification, epidemiology, pathophysiology, diagnosis, and risk factors of DED...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27215597/the-prevalence-of-visual-impairment-in-retirement-home-residents
#18
Luisa Thederan, Susanne Steinmetz, Sabine Kampmann, Anna-Maria Koob-Matthes, Franz Grehn, Thomas Klink
BACKGROUND: Elderly persons often have eye diseases causing either reversible or irreversible visual loss. The prevalence of such problems among retirement home residents is unknown. METHODS: 203 residents of retirement homes in and around Würzburg, Germany, were examined. Clinical histories were taken, including information on prior ophthalmological care, and ophthalmological examinations were performed, including visual acuity, slit-lamp examination of the anterior segment of the eye, fundoscopy (with optical coherence tomography), and measurement of the intraocular pressure...
May 6, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27213797/-significance-of-laser-confocal-tomography-in-diagnosis-and-monitoring-of-keratoconjunctivitis-sicca
#19
T N Safonova, O V Gladkova, V I Boev
UNLABELLED: Laser confocal tomography of the cornea enables studying ultrathin sections of corneal layers, which provides additional reliable information on tissue changes in keratoconjunctivitis sicca (KCS). AIM: To assess the significance of laser confocal tomography of the cornea in the diagnosis and monitoring of KCS. MATERIAL AND METHODS: We investigated 38 eyes of 30 patients with severe KCS. The patients were divided into two groups...
March 2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27213053/dry-eye-syndrome-in-patients-with-diabetes-mellitus-prevalence-etiology-and-clinical-characteristics
#20
REVIEW
Xinyuan Zhang, Lin Zhao, Shijing Deng, Xuguang Sun, Ningli Wang
There has been substantial progress in our understanding of the ocular surface system/lacrimal function unit in the past 15 years. Keratoconjunctivitis sicca, more commonly referred to as dry eye syndrome (DES), is the most frequently encountered condition and diabetes mellitus (DM) has been identified as one of the leading causes of DES. Poor glycemic control affects both the anterior and the posterior segments of the eye and increasing prevalence of diabetes-associated DES (DMDES) has been reported in recent years...
2016: Journal of Ophthalmology
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