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https://www.readbyqxmd.com/read/29792288/tralokinumab-for-severe-uncontrolled-asthma-stratos-1-and-stratos-2-two-randomised-double-blind-placebo-controlled-phase-3-clinical-trials
#1
Reynold A Panettieri, Ulf Sjöbring, AnnaMaria Péterffy, Peter Wessman, Karin Bowen, Edward Piper, Gene Colice, Christopher E Brightling
BACKGROUND: Tralokinumab is an anti-interleukin-13 human monoclonal antibody developed for the treatment of severe, uncontrolled asthma. These clinical trials aimed to assess the efficacy and safety of tralokinumab in this population. METHODS: STRATOS 1 and STRATOS 2 were randomised, double-blind, parallel-group, placebo-controlled, phase 3 clinical trials that enrolled participants aged 12-75 years with severe asthma that was inadequately controlled despite use of inhaled corticosteroids (≥500 μg per day fluticasone or equivalent) and a long-acting β2 agonist (but not oral corticosteroids)...
May 18, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29790954/clinical-use-of-intracoronary-imaging-part-1-guidance-and-optimization-of-coronary-interventions-an-expert-consensus-document-of-the-european-association-of-percutaneous-cardiovascular-interventions-endorsed-by-the-chinese-society-of-cardiology
#2
Lorenz Räber, Gary S Mintz, Konstantinos C Koskinas, Thomas W Johnson, Niels R Holm, Yoshinubo Onuma, Maria D Radu, Michael Joner, Bo Yu, Haibo Jia, Nicolas Menevau, Jose M de la Torre Hernandez, Javier Escaned, Jonathan Hill, Francesco Prati, Antonio Colombo, Carlo di Mario, Evelyn Regar, Davide Capodanno, William Wijns, Robert A Byrne, Giulio Guagliumi
This Consensus Document is the first of two reports summarizing the views of an expert panel organized by the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on the clinical use of intracoronary imaging including intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The first document appraises the role of intracoronary imaging to guide percutaneous coronary interventions (PCIs) in clinical practice. Current evidence regarding the impact of intracoronary imaging guidance on cardiovascular outcomes is summarized, and patients or lesions most likely to derive clinical benefit from an imaging-guided intervention are identified...
May 22, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29790719/less-is-more-as-less-as-reasonably-achievable-stenting-alaras-strategy-in-the-femoropopliteal-area
#3
Koen Deloose, Joren Callaert
BACKGROUND: Although evidence supports that the performance of drug coated balloons seems to be lesion complexity independent, it is quite clear that in long lesions, severe calcified lesions and chronic total occlusions, the bail out stent ratio is very high and that the "leaving nothing behind" strategy remains a dream in a lot of our daily cases. On the other side of the spectrum, "full metal jackets" of nitinol stents are creating even more problems. Stent fractures, intimal hyperplasia and reintervention difficulties complicate the recurrent vascular disease treatment...
May 23, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29790285/peripapillary-vessel-density-changes-in-leber-s-hereditary-optic-neuropathy-a-new-biomarker
#4
Nicole Balducci, Maria Lucia Cascavilla, Antonio Ciardella, Chiara La Morgia, Giacinto Triolo, Vincenzo Parisi, Francesco Bandello, Alfredo A Sadun, Valerio Carelli, Piero Barboni
IMPORTANCE: The contribution of the microvascular supply to the pathogenesis of Leber's Hereditary Optic Neuropathy (LHON) is poorly understood. BACKGROUND: We aimed at measuring the peripapillary capillary vessel density (VD) using optical coherence tomography angiography (OCT-A) at different stages of LHON. DESIGN: Prospective, cross-sectional, multicenter, observational study. PARTICIPANTS: Twenty-two LHON patients divided in 4 groups: unaffected mutation carriers (LHON-u); early subacute stage (LHON-e); late subacute stage (LHON-l); chronic stage (LHON-ch)...
May 22, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29790037/one-year-optical-coherence-tomography-findings-in-patients-with-late-and-very-late-stent-thrombosis-treated-with-intravascular-imaging-guided-percutaneous-coronary-intervention
#5
Marcos Ñato, Josep Gomez-Lara, Rafael Romaguera, Gerard Roura, José Luis Ferreiro, Luis Teruel, Montserrat Gracida, Lara Fuentes, Bert Vandeloo, Joan-Antoni Gomez-Hospital, Angel Cequier
Patients with late/very-late stent thrombosis (ST) are at high risk of recurrent-ST. The mechanisms of recurrent-ST are largely unknown. The objective is to describe the 1-year optical coherence tomography (OCT) findings of patients suffering from late/very-late ST treated with intravascular imaging guided percutaneous coronary intervention (PCI). All consecutive patients with late/very-late ST undergoing intravascular imaging guided PCI were screened to undergo coronary angiography and OCT examination at 1 year...
May 22, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29789898/-clinical-parameters-of-patients-with-neovascular-age-related-macular-degeneration-longterm-treatment-results-of-an-outpatient-clinic
#6
S Wassel, E Tsompanidi, E Tahmaz, B Hörster, R Hoerster
BACKGROUND: The clinical outcome of neovascular age-related macular degeneration (nAMD) depends on constant follow-up and consistent treatment. Data about the long-term course of intensive anti-vascular endothelial growth factor (VEGF) therapy from outpatient clinics are rare. OBJECTIVE: The aim of the study was to characterize a population of nAMD patients with long-term follow-up and intensive anti-VEGF therapy. PATIENTS AND METHODS: In a supra-regional outpatient clinic, we retrospectively identified patients who had received at least 30 intravitreal anti-VEGF injections and were followed for at least 4 years...
May 22, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29789660/multicolor-tm-imaging-in-combined-hamartoma-of-the-retina-and-retinal-pigment-epithelium
#7
Konstantinos Kaprinis, Hannaa Bobat, Gabriella De Salvo
PURPOSE: To describe the principle characteristics of combined hamartoma of the retina and retinal pigment epithelium ('combined harmatoma') on MultiColorTM imaging and evaluate its role as a diagnostic and management tool. METHODS: Retrospective, observational case series comprising three patients with unilateral, juxtapapillary combined harmatoma. Complete ophthalmic examination was performed. MultiColorTM , including green reflectance (GR) and near infra-red reflectance (NIRR), optical coherence tomography (OCT) and autofluorescence (AF) imaging were obtained (Heidelberg Spectralis)...
May 23, 2018: Eye
https://www.readbyqxmd.com/read/29789659/comparison-of-glaucoma-diagnostic-ability-between-wide-field-swept-source-oct-retinal-nerve-fiber-layer-maps-and-spectral-domain-oct
#8
Won June Lee, Sohee Oh, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
PURPOSE: To compare the diagnostic ability of wide-field swept-source optical coherence tomography (SS-OCT) retinal nerve fiber layer (RNFL) maps with spectral-domain OCT (SD-OCT) maps for detection of preperimetric (PPG) and early glaucoma (EG). PATIENTS AND METHODS: One hundred and forty-six eyes, including 37 healthy eyes, 38 eyes with PPG, and 71 eyes with EG, were analyzed. The patients underwent both SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA, USA) and wide-field SS-OCT scanning (DRI-OCT-1 Atlantis; Topcon, Tokyo, Japan)...
May 23, 2018: Eye
https://www.readbyqxmd.com/read/29788263/temporal-course-of-vascular-healing-and-neoatherosclerosis-after-implantation-of-durable-or-biodegradable-polymer-drug-eluting-stents
#9
Giulio Guagliumi, Kunihiro Shimamura, Vasile Sirbu, Roberto Garbo, Giacomo Boccuzzi, Angelina Vassileva, Orazio Valsecchi, Luigi Fiocca, Paolo Canova, Francesco Colombo, Gabriel Tensol Rodriguez Pereira, Daisuke Nakamura, Guilherme F Attizzani, Alberto Cereda, Keisuke Satogami, Leonardo De Luca, Francesco Saia, Davide Capodanno
Aims: Delayed healing and endothelial dysfunction may occur with drug-eluting stents (DES), promoting accelerated infiltration of lipids in the neointima and development of neoatherosclerosis (NA). Pathology data suggest durable polymer (DP) of DES to play a major role in this process. Whether biodegradable polymer (BP) may address these issues is uncertain. We compared in vivo vessel healing and NA of current generation BP- or DP-DES using serial optical coherence tomography (OCT) assessments...
May 19, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29787603/association-of-ocular-cardiovascular-morphometric-and-lifestyle-parameters-with-retinal-nerve-fibre-layer-thickness
#10
Julia Lamparter, Irene Schmidtmann, Alexander K Schuster, Angeliki Siouli, Joanna Wasielica-Poslednik, Alireza Mirshahi, René Höhn, Josef Unterrainer, Philipp S Wild, Harald Binder, Karl Lackner, Manfred E Beutel, Thomas Münzel, Norbert Pfeiffer, Esther M Hoffmann
BACKGROUND: Glaucoma is a neurodegenerative disease, leading to thinning of the retinal nerve fibre layer (RNFL). The exact influence of ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFL thickness (RNFLT) is unknown and was analysed in a subgroup of the Gutenberg Health Study (GHS). METHODS: Global peripapillary RNFLT was measured in 3224 eyes of 1973 subjects (49% female) using spectral-domain optical coherence tomography (SD-OCT). The association of age, sex, ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFLT was analysed using Pearson correlation coefficient and fitting a linear mixed model...
2018: PloS One
https://www.readbyqxmd.com/read/29787354/optical-coherence-tomography-of-the-tympanic-membrane-and-middle-ear-a-review
#11
Hsern Ern Ivan Tan, Peter Luke Santa Maria, Philip Wijesinghe, Brendan Francis Kennedy, Benjamin James Allardyce, Robert Henry Eikelboom, Marcus David Atlas, Rodney James Dilley
Objective To evaluate the recent developments in optical coherence tomography (OCT) for tympanic membrane (TM) and middle ear (ME) imaging and to identify what further development is required for the technology to be integrated into common clinical use. Data Sources PubMed, Embase, Google Scholar, Scopus, and Web of Science. Review Methods A comprehensive literature search was performed for English language articles published from January 1966 to January 2018 with the keywords "tympanic membrane or middle ear,"optical coherence tomography," and "imaging...
May 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29787321/enhanced-depth-imaging-by-high-resolution-spectral-domain-optical-coherence-tomography-in-tubercular-multifocal-serpiginoid-choroiditis
#12
Bruttendu Moharana, Reema Bansal, Ramandeep Singh, Aman Sharma, Vishali Gupta, Amod Gupta
PURPOSE: To report the choroidal changes by enhanced depth imaging optical coherence tomography (EDI-OCT) in tubercular multifocal serpiginoid choroiditis (MSC). METHODS: Prospective study of 20 patients (23 eyes) with active MSC who underwent simultaneous fundus autofluorescence and EDI-OCT imaging at regular visits. RESULTS: Eyes with acute lesions demonstrated diffuse choroidal thickening at presentation, which decreased significantly as the lesions healed...
May 22, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29786009/comparison-of-optical-coherence-tomography-angiography-and-fundus-fluorescein-angiography-features-of-retinal-capillary-hemangioblastoma
#13
Pradeep Sagar, R Rajesh, Mahesh Shanmugam, Vinaya Kumar Konana, Divyansh Mishra
The aim of this study is to compare the optical coherence tomography angiography (OCTA) and fundus fluorescein angiography (FFA) features of retinal capillary hemangioblastoma (RCH). This is an observational case series of three patients with von Hippel-Lindau (VHL) disease and one patient with juxtapapillary RCH. All patients underwent FFA with a mydriatic fundus camera and OCTA with swept-source angio OCT. The FFA and OCTA characteristics of tumors were compared. In our series, FFA could identify tumors as small as the width of a third-order retinal artery, which was missed on clinical examination...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785993/factors-predicting-response-of-pseudophakic-cystoid-macular-edema-to-topical-steroids-and-nepafenac
#14
Sabyasachi Sengupta, Dhaivat Vasavada, Utsab Pan, Manavi Sindal
Purpose: The purpose of this study is to determine factors predicting resolution of acute pseudophakic cystoid macular edema (PCME) after 6 weeks of topical prednisolone and nepafenac application. Methods: Case records of patients with a clinical and optical coherence tomography (OCT)-based diagnosis of acute PCME were retrospectively reviewed for best-corrected visual acuity and OCT-based parameters at the time of presentation with PCME. In addition, demographic variables, intraoperative and early postoperative factors, and type of treatment prescribed (tapering vs...
June 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29785464/contribution-of-cochlear-compression-to-discrimination-of-rippled-spectra-in-on-and-low-frequency-noise
#15
Olga N Milekhina, Dmitry I Nechaev, Alexander Ya Supin
The goal of the study was to assess cochlear compression when rippled-spectrum signals are perceived in noise assuming that the noise might produce both masking and confounding effects. In normal listeners, discrimination between rippled signals with and without ripple phase reversals was assessed in background noise. The signals were band-limited (0.5 oct at a - 6-dB level) rippled noise centered at 2 kHz, with a ripple density of 3.5 oct-1 . The noise (masker) was band-limited nonrippled noise centered at either 2 kHz (on-frequency masker) or 1 kHz (low-frequency masker)...
May 21, 2018: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/29784630/what-are-the-causes-of-a-suboptimal-ffr-after-coronary-stent-deployment-insights-from-a-consecutive-series-using-oct-imaging
#16
Mathias Wolfrum, Giovanni Luigi De Maria, Stefano Benenati, Jeremy Langrish, Andrew J Lucking, Keith M Channon, Rajesh K Kharbanda, Adrian P Banning
AIMS: Fractional flow reserve (FFR) can be used to detect a suboptimal result after percutaneous coronary intervention (PCI). A lower post procedure FFR (< 0.90) has been shown to be associated with adverse clinical outcomes at follow-up. This pilot study aimed to understand the mechanisms resulting in a suboptimal FFR and whether Optical Coherence Tomography (OCT) guided optimisation could improve final FFR. METHODS AND RESULTS: Thirty five patients undergoing complex PCI were prospectively enrolled...
May 21, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29784091/swept-source-oct-of-a-scleral-tunnel-in-choroideremia
#17
Christy M Cunningham, D Brice Critser, Ian C Han
No abstract text is available yet for this article.
June 2018: Ophthalmology
https://www.readbyqxmd.com/read/29783822/-evaluations-of-newborn-screening-program-performance-and-enzymatic-diagnosis-of-glucose-6-phosphate-dehydrogenase-deficiency-in-guangzhou
#18
F Tang, Y L Huang, X Jiang, X F Jia, B Li, Y Feng, Q Y Chen, C F Tang
Objective: To reveal the molecular epidemiologic characteristics of glucose-6-phosphate dehydrogenase (G6PD) gene and to evaluate based on the genetic analysis the newborn screening program performance and enzymatic diagnosis of G6PD deficiency in Guangzhou. Methods: G6PD enzyme activities were measured by quantitative fluorescence assay in dry blood spots of 16 319 newborns(8 725 males, 7 594 females) 3-7 days after birth in Guangzhou Newborn Center. They were born in Guangzhou form Oct. 1 to 20, 2016. The cutoff value of G6PD was less than 2...
May 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29783074/fsh-receptor-binding-inhibitor-restrains-follicular-development-and-possibly-attenuates-carcinogenesis-of-ovarian-cancer-through-down-regulating-expression-levels-of-fshr-and-er%C3%AE-in-normal-ovarian-tissues
#19
Gong Zhuandi, Che Tuanjie, Lai Luju, Ayimuguli Abdiryim, Deng Yingying, Liang Haoqin, Wei Suocheng, Ding Li
OBJECTIVES: The current study aimed to investigate FSH receptor binding inhibitor (FRBI) effects in the expressions of FSH receptor (FSHR) and estrogen receptor-beta (ERβ) in the mice ovaries at the gene and protein levels, also to find the potential efficacy of FRBI on suppressing ovarian cancer through down-regulating over-expression of FSHR and ERβ in the normal ovarian tissues. METHODS: 180 female mice were randomized into six groups (n = 30). Mice of FRBI-1, FRBI-2 and FRBI-3, FRBI-4 were intramuscularly injected with FRBI of 10, 20, 30 and 40 mg/kg, respectively, for five consecutive days...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29782826/sheets-of-human-retinal-progenitor-transplants-improve-vision-in-rats-with-severe-retinal-degeneration
#20
Bin Lin, Bryce T McLelland, Anuradha Mathur, Robert B Aramant, Magdalene J Seiler
Loss of photoreceptors and other retinal cells is a common endpoint in retinal degenerate (RD) diseases that cause blindness. Retinal transplantation is a potential therapy to replace damaged retinal cells and improve vision. In this study, we examined the development of human fetal retinal sheets with or without their retinal pigment epithelium (RPE) transplanted to immunodeficient retinal degenerate rho S334ter-3 rats. Sheets were dissected from fetal human eyes (11-15.7 weeks gestation) and then transplanted to the subretinal space of 24-31 d old RD nude rats...
May 18, 2018: Experimental Eye Research
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