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Obesity, OSA, Cardiac evaluation

Anne Briançon-Marjollet, Denis Monneret, Marion Henri, Marie Joyeux-Faure, Perle Totoson, Sandrine Cachot, Patrice Faure, Diane Godin-Ribuot
What is the central question of this study? This study addresses the relative impact of obesity and intermittent hypoxia in the pathophysiological process of obstructive sleep apnoea by investigating the metabolic, inflammatory and cardiovascular consequences of intermittent hypoxia in lean and obese Zucker rats. What is the main finding and its importance? We found that obesity and intermittent hypoxia have mainly distinct consequences on the investigated inflammatory and cardiometabolic parameters in Zucker rats...
October 5, 2016: Experimental Physiology
José Antonio Pinto, Davi Knoll Ribeiro, Andre Freitas da Silva Cavallini, Caue Duarte, Gabriel Santos Freitas
Introduction Obstructive sleep apnea (OSA) is characterized by partial or complete recurrent upper airway obstruction during sleep. OSA brings many adverse consequences, such as hypertension, obesity, diabetes mellitus, cardiac and encephalic alterations, behavioral, among others, resulting in a significant source of public health care by generating a high financial and social impact. The importance of this assessment proves to be useful, because the incidence of patients with comorbidities associated with AOS has been increasing consistently and presents significant influence in natural disease history...
April 2016: International Archives of Otorhinolaryngology
Muntecep Asker, Selvi Asker
BACKGROUND AND AIM OF THE STUDY: It was hypothesized that sleep disorders might be present due to functional heart failure in patients with mitral stenosis (MS), and might be accompanied by obstructive-type sleep disorders. To examine this hypothesis, non-smoker and non-obese patients with rheumatic MS and without concomitant diseases were investigated for sleep disorders. METHODS: Patients admitted to the cardiology outpatient clinic at the authors' institution for rheumatic MS during a one-year period were included in the study...
May 2015: Journal of Heart Valve Disease
Deidre R Larrier, Zhen J Huang, Wei Zhang, Catherine H McHugh, Linda Brock, S Chandra-Bose Reddy
BACKGROUND: Adenotonsillectomy (T&A) is a common surgery performed for obstructive sleep apnea (OSA) in children. Obese children are at increased risk for OSA, but are also at increased risk for cardiovascular changes that might heighten their risk of undergoing a general anesthetic. There is currently no standard of care recommendation for cardiac workup prior to T&A. PURPOSE: To ascertain whether a preoperative cardiac workup is predictive of postoperative complications in obese children undergoing T&A for OSA...
November 2015: American Journal of Otolaryngology
Viral Doshi, Nang Kham, Shreedhar Kulkarni, Kent Kapitan
Obstructive Airway Disease CasesSESSION TYPE: Affiliate Case Report SlidePRESENTED ON: Sunday, October 26, 2014 at 03:15 PM - 04:15 PMINTRODUCTION: Freon 12B2 is widely used as a refrigerant, solvent and in aerosol applications. Accidental or intentional inhalation of Freon can lead to severe adverse outcomes in humans like transient confusion, cardiac arrhythmia and asphyxia. We report a rare case of reactive airway dysfunction syndrome secondary to Freon inhalation.CASE PRESENTATION: A 60-year-old male with a past medical history of diabetes, morbid obesity, Obstructive sleep apnea was referred to pulmonary clinic for evaluation of shortness of breath...
October 1, 2014: Chest
Graziela De Luca Canto, Camila Pachêco-Pereira, Secil Aydinoz, Paul W Major, Carlos Flores-Mir, David Gozal
OBJECTIVE: The purpose of this systematic review is to evaluate the diagnostic value of biological markers (exhaled breath condensate, blood, salivary and urinary) in the diagnosis of OSA in comparison to the gold standard of nocturnal PSG. METHODS: Studies that differentiated OSA from controls based on PSG results, without age restriction, were eligible for inclusion. The sample of selected studies could include studies in obese patients and with known cardiac disease...
January 15, 2015: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Dionne F Peacher, Stefanie D Martina, Claire E Otteni, Tracy E Wester, Jennifer F Potter, Richard Edward Moon
PURPOSE: Immersion pulmonary edema (IPE) occurs in swimmers (especially triathletes) and scuba divers. Its pathophysiology and risk factors are incompletely understood. This study was designed to establish the prevalence of preexisting comorbidities in individuals who experience IPE. METHODS: From 2008 to May 2010, individuals who had experienced IPE were identified via recruitment for a physiological study. Past medical history and subject characteristics were compared with those available in the current body of literature...
June 2015: Medicine and Science in Sports and Exercise
Carla A Evans, Hiran Selvadurai, Louise A Baur, Karen A Waters
STUDY OBJECTIVES: Evaluate the relative contributions of weight status and obstructive sleep apnea (OSA) to cardiopulmonary exercise responses in children. DESIGN: Prospective, cross-sectional study. Participants underwent anthropometric measurements, overnight polysomnography, spirometry, cardiopulmonary exercise function testing on a cycle ergometer, and cardiac doppler imaging. OSA was defined as ≥ 1 obstructive apnea or hypopnea per hour of sleep (OAHI). The effect of OSA on exercise function was evaluated after the parameters were corrected for body mass index (BMI) z-scores...
June 2014: Sleep
Madhulika A Gupta, Katie Knapp
PURPOSE: To evaluate cardiovascular and psychiatric morbidity in patient visits with obstructive sleep apnea (OSA) with insomnia (OSA+Insomnia) versus OSA without insomnia (OSA-Insomnia) in a nationally representative US sample. METHODS: A retrospective case-control study of epidemiologic databases (National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey) representing an estimated ± standard error (SE) 62,253,910 ± 5,274,747 (unweighted count=7234) patient visits with diagnosis of OSA from 1995-2010, was conducted...
2014: PloS One
Swarna Gaddam, Sameer K Gunukula, M Jeffery Mador
BACKGROUND: With the current obesity epidemic, obstructive sleep apnea (OSA) has become increasingly common. Several studies have reported on the risk of post-operative complications in OSA patients undergoing non-upper airway surgeries. The objective of our study was to systematically review the medical literature reporting the incidence of post-operative complications in patients with OSA. METHODS: We conducted a systematic review using the Cochrane Collaboration Methodology...
September 2014: Sleep & Breathing, Schlaf & Atmung
Dimitris Kardassis, Ludger Grote, Lars Sjöström, Jan Hedner, Kristjan Karason
OBJECTIVE: Obesity is frequently associated with obstructive sleep apnea (OSA). Both conditions are proinflammatory and proposed to deteriorate cardiac function. We used a nested cohort study design to evaluate the long-term impact of bariatric surgery on OSA and how weight loss and OSA relate to inflammation and cardiac performance. DESIGN AND METHODS: At 10-year follow-up in the Swedish Obese Subjects (SOS) study, we identified 19 obese subjects (BMI 31.2 ± 5...
April 2013: Obesity
Ken-Ichi Maeno, Takatoshi Kasai, Satoshi Kasagi, Fusae Kawana, Sugao Ishiwata, Minoru Ohno, Tetsu Yamaguchi, Koji Narui
Prolonged P-wave duration, indicating atrial conduction delay, is a marker of left atrial abnormality and is reported as a potent precursor of atrial fibrillation (AF). Several studies have shown that obstructive sleep apnea (OSA) is associated with AF. We evaluated the relationship between OSA and prolonged P-wave duration. Consecutive subjects who underwent overnight polysomnography and showed a normal sinus rhythm, had no history of AF or ischemic heart disease, and showed no evidence of heart failure were enrolled...
September 2013: Heart and Vessels
Viktor Persic
A higher prevalence of coronary heart disease, cardiac and overall mortality is associated with obesity. The development of obesity appears in different adaptations in the morphology of cardiac structure and function. Obesity causes eccentric hypertrophy and changes in diastolic function of left ventricle. A systolic on diastolic heart dysfunction results from the breakdown of compensatory pace to raised wall stress and dilatation of chambers. Obesity does not possess primary cause and effect relationship with cardiovascular disease, such as LDL cholesterol...
May 2013: Current Clinical Pharmacology
Massimo R Mannarino, Francesco Di Filippo, Matteo Pirro
Obstructive sleep apnea (OSA) syndrome is a common but often unrecognized disorder caused by pharyngeal collapse during sleep and characterized by frequent awakenings, disrupted sleep and consequent excessive daytime sleepiness. With the increasing epidemic of obesity, the most important risk factor for OSA, prevalence of the disease will increase over the coming years thus representing an important public-health problem. In fact, it is now recognized that there is an association between OSA and hypertension, metabolic syndrome, diabetes, heart failure, coronary artery disease, arrhythmias, stroke, pulmonary hypertension, neurocognitive and mood disorders...
October 2012: European Journal of Internal Medicine
Ronald M Harper, Rajesh Kumar, Paul M Macey, Jennifer A Ogren, Heidi L Richardson
A major concern with sleep-disordered breathing conditions, which include obstructive sleep apnea (OSA), central apnea, and congenital central hypoventilation syndrome (CCHS), is the high incidence of accompanying autonomic dysfunction and metabolic disorders. Patients with OSA show exaggerated sympathetic tone, leading to hypertension, cardiac arrhythmia, profuse sweating, impaired cerebral perfusion, and stroke. In addition, OSA appears in 86% of obese Type II diabetic patients, suggesting common deleterious processes...
September 2012: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
K M Jensen, L C Taylor, M M Davis
BACKGROUND: Due to significant medical improvements, persons with Down syndrome now live well into adulthood. Consequently, primary care for adults with Down syndrome needs to incorporate routine care with screening for condition-specific comorbidities. This study seeks to evaluate the adherence of primary care physicians to age- and condition-specific preventive care in a cohort of adults with Down syndrome. METHODS: In this retrospective observational cohort study, preventive screening was evaluated in patients with Down syndrome aged 18-45 years who received primary care in an academic medical centre from 2000 to 2008...
May 2013: Journal of Intellectual Disability Research: JIDR
Anna M Grandi, Emanuela Laurita, Chiara Marchesi, Andrea M Maresca, Francesco Solbiati, Antonella Bernasconi, Maurizio Marogna, Claudio Salina, Eleonora Nicolini, Luigina Guasti, Fausto Colombo, Achille Venco
BACKGROUND: We evaluated whether obstructive sleep apnoea (OSA) and continuous positive airway pressure (CPAP) treatment influence left ventricular (LV) remodelling independently of abdominal obesity and metabolic syndrome (MetS). METHODS: Cardiorespiratory examination, 24-h BP monitoring and echocardiogram were performed in overweight/obese patients with increased abdominal adiposity and symptoms suggesting OSA : OSA/MetS (n.50), OSA/noMetS (n.22), noOSA/MetS (n...
January 2012: Respiratory Medicine
Alain Lurie
Obstructive sleep apnea (OSA) is characterized by repetitive episodes of complete and partial obstructions of the upper airway during sleep. The diagnosis of OSA requires the objective demonstration of abnormal breathing during sleep by measuring the respiratory disturbance index (RDI, events per hour of sleep), i.e. the frequency of apnea (complete upper airway obstruction), hypopnea (partial upper airway obstruction) and arousals from sleep related to respiratory efforts. OSA is defined by combining symptoms and an RDI ≥5 or by an RDI ≥15 without symptoms...
2011: Advances in Cardiology
Jay S Balachandran, Jessie P Bakker, Shilpa Rahangdale, Susie Yim-Yeh, Joseph E Mietus, Ary L Goldberger, Atul Malhotra
Dysregulation of autonomic nervous system dynamics is important in the pathophysiology of cardiovascular risk in obstructive sleep apnea (OSA). Heart rate variability (HRV) and impedance cardiography measures can estimate autonomic activity but have not gained traction clinically. The hypothesis of this study was that even in a cohort of patients with mild, asymptomatic OSA without overt cardiovascular disease, daytime HRV metrics and impedance cardiography measurements of preejection period would demonstrate increased sympathetic and decreased parasympathetic modulation compared to matched controls...
January 1, 2012: American Journal of Cardiology
Yasuhiro Usui, Yoshifumi Takata, Yuichi Inoue, Hirofumi Tomiyama, Saiko Kurohane, Yuki Hashimura, Kota Kato, Hirokazu Saruhara, Kihiro Asano, Kazuki Shiina, Akira Yamashina
OBJECTIVE: To evaluate whether obstructive sleep apnea (OSA) contributes directly to left ventricular (LV) diastolic dysfunction. METHODS: Seventy-four non-obese male OSA (apnea hypopnea index (AHI)⩾5/h) patients without cardiac disease, hypertension or diabetes were enrolled. Echocardiography, pulse wave velocity (PWV) measurements and laboratory testing were performed in all patients. LV diastolic function was assessed by the transmitral flow velocity (E/A ratio), and mitral annular velocity (Ea) was derived from tissue Doppler imaging (TDI)...
February 2013: Sleep Medicine
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