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https://www.readbyqxmd.com/read/29142658/magnetic-resonance-imaging-of-pineal-tumors-and-drop-metastases-a-review-approach
#1
Aikaterini G Solomou
No abstract text is available yet for this article.
October 3, 2017: Rare Tumors
https://www.readbyqxmd.com/read/29139015/defining-the-optimal-midline-shift-threshold-to-predict-poor-outcome-in-patients-with-supratentorial-spontaneous-intracerebral-hemorrhage
#2
Wen-Song Yang, Qi Li, Rui Li, Qing-Jun Liu, Xing-Chen Wang, Li-Bo Zhao, Peng Xie
BACKGROUND: Midline shift (MLS) has been associated with unfavorable outcome in patients with intracerebral hemorrhage (ICH). However, the optimal criteria to define the MLS measurements that indicate future outcome in ICH patients are absent, and the quantitative threshold of MLS that differentiates favorable and poor clinical outcome should be further explored. METHODS: We enrolled patients with ICH who underwent admission computed tomography (CT) within 6 h after onset of symptoms...
November 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29137263/melatonin-suppresses-hepatocellular-carcinoma-progression-via-lncrna-cps1-it-mediated-hif-1%C3%AE-inactivation
#3
Tong-Hong Wang, Chi-Hao Wu, Chau-Ting Yeh, Shih-Chi Su, Shih-Min Hsia, Kung-Hao Liang, Chin-Chuan Chen, Chuen Hsueh, Chi-Yuan Chen
Melatonin is the primary pineal hormone that relays light/dark cycle information to the circadian system. It was recently reported to exert intrinsic antitumor activity in various cancers. However, the regulatory mechanisms underlying the antitumor activity of melatonin are poorly understood. Moreover, a limited number of studies have addressed the role of melatonin in hepatocellular carcinoma (HCC), a major life-threatening malignancy in both sexes in Taiwan. In this study, we investigated the antitumor effects of melatonin in HCC and explored the regulatory mechanisms underlying these effects...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136773/the-potential-use-of-melatonin-to-treat-protozoan-parasitic-infections-a-review
#4
REVIEW
Ahmad Daryani, Mahbobeh Montazeri, Abdol Satar Pagheh, Mehdi Sharif, Shahabeddin Sarvi, Azam Hosseinzadeh, Russel J Reiter, Ramtin Hadighi, Mohammad Taghi Joghataei, Habib Ghaznavi, Saeed Mehrzadi
Melatonin (N-acetyl-5-methoxytryptamine) is a circadian hormone produced in vertebrates by the pineal gland and other organs. Melatonin is believed to influence immune cells leading to modulation of the proliferative response of stimulated lymphocytes as well as cytokine production. Due to the antioxidant and immunomodulatory effects of melatonin, it is suggested that this molecule could be a therapeutic alternative agent to fight bacterial, viral, and parasitic infections by a variety of mechanisms. Herein, we review the effects of melatonin on the cell biology of protozoan parasites and host's immune response...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29131126/extending-the-neuroanatomic-territory-of-diffuse-midline-glioma-k27m-mutant-pineal-region-origin
#5
Andrea R Gilbert, Wafik Zaky, Murat Gokden, Christine E Fuller, Eylem Ocal, Norman E Leeds, Gregory N Fuller
Diffuse midline glioma, H3-K27M mutant (DMG-K27M) is a newly described, molecularly distinct infiltrative glioma that almost exclusively arises in midline CNS structures, including the brain stem, especially the pons, as well as the thalamus and spinal cord with rare examples seen in the cerebellum, third ventricle, and hypothalamus. To our knowledge, only 1 case of a molecularly confirmed DMG-K27M arising in the pineal region has been previously reported. We present the second occurrence of a tissue-confirmed DMG-K27M of the pineal region, which, to our knowledge, is the first case reported in a child and the first case with documented preoperative MRI...
November 4, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29124531/identification-of-peptide-aedg-in-the-polypeptide-complex-of-the-pineal-gland
#6
V Kh Khavinson, A T Kopylov, B V Vaskovsky, G A Ryzhak, N S Lin'kova
The polypeptide complex of the epiphysis and the peptide AEDG, constructed on the basis of its amino acid analysis, exert similar biological effects. Both bioregulators normalize melatonin synthesis in the pineal gland, functioning of the brain, eye retina, cardiovascular, endocrine, and immune systems; they also act as antioxidants, stress-protectors, and geroprotectors. Within the epiphysis polypeptide complex, free amino acids (3.26%), dipeptides (23.19%), tripeptides (50.72%), tetrapeptides (22.10%), and pentapeptides (0...
November 9, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29122492/d-leucine-evaluation-in-an-epilepsy-model
#7
Kylie Holden, Adam L Hartman
BACKGROUND: Current medicines do not provide sufficient seizure control for nearly one-third of patients with epilepsy. New options are needed to address this treatment gap. We recently found that the atypical amino acid d-leucine protected against acutely-induced seizures in mice, but its effect in chronic seizures has not been explored. We hypothesized that d-leucine would protect against spontaneous recurrent seizures. We also investigated whether mice lacking a previously-described d-leucine receptor (Tas1R2/R3) would be protected against acutely-induced seizures...
November 7, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29118419/melatonin-promotes-triacylglycerol-accumulation-via-mt2-receptor-during-differentiation-in-bovine-intramuscular-preadipocytes
#8
Wucai Yang, Keqiong Tang, Yaning Wang, Yingying Zhang, Linsen Zan
Melatonin (N-acetyl-5-methoxytryptamine) is a derivative of tryptophan which is produced and secreted mainly by the pineal gland and regulates a variety of important central and peripheral actions. To examine the potential effects of melatonin on the proliferation and differentiation of bovine intramuscular preadipocytes (BIPs), BIPs were incubated with different concentrations of melatonin. Melatonin supplementation at 1 mM significantly increased peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer-binding protein (C/EBP) β, and C/EBPα expression and promoted the differentiation of BIPs into adipocytes with large lipid droplets and high cellular triacylglycerol (TAG) levels...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29105727/immune-pineal-axis-acute-inflammatory-responses-coordinate-melatonin-synthesis-by-pinealocytes-and-phagocytes
#9
REVIEW
Regina P Markus, Pedro A Fernandes, Gabriela S Kinker, Sanseray da Silveira Cruz-Machado, Marina Marçola
Melatonin is well known for its circadian production by the pineal gland, with a growing body of data showing its production by many other cells and organs, including immune cells. The chronobiotic role of pineal melatonin, as well as its protective effects in vitro and in vivo, have been extensively explored. However, the interaction between chronobiotic and defence functions of endogenous melatonin has been little investigated. This review details the current knowledge regarding the coordinated shift in melatonin synthesis from the pineal (circadian and monitoring roles) to the regulation of acute immune responses via immune cell production and autocrine effects, producing system interactions termed the immune-pineal axis...
November 4, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29101614/visual-outcome-after-endoscopic-third-ventriculostomy-for-hydrocephalus
#10
Ji-Ho Jung, Yong-Hyun Chai, Shin Jung, In-Young Kim, Woo-Youl Jang, Kyung-Sub Moon, Seul-Kee Kim, Sangjoon Chong, Seung-Ki Kim, Tae-Young Jung
PURPOSE: Hydrocephalus-related symptoms are mostly improved after successful endoscopic third ventriculostomy (ETV). However, visual symptoms can be different. This study was focused on visual symptoms. We analyzed the magnetic resonance images (MRI) of the orbit and visual outcomes. METHODS: From August 2006 to November 2016, 50 patients with hydrocephalus underwent ETV. The male-to-female ratio was 33:17, and the median age was 61 years (range, 5-74 years). There were 18 pediatric and 32 adult patients...
November 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29100543/characterization-of-a-thalamic-nucleus-mediating-habenula-responses-to-changes-in-ambient-illumination
#11
Ruey-Kuang Cheng, Seetha Krishnan, Qian Lin, Caroline Kibat, Suresh Jesuthasan
BACKGROUND: Neural activity in the vertebrate habenula is affected by ambient illumination. The nucleus that links photoreceptor activity with the habenula is not well characterized. Here, we describe the location, inputs and potential function of this nucleus in larval zebrafish. RESULTS: High-speed calcium imaging shows that light ON and OFF both evoke a rapid response in the dorsal left neuropil of the habenula, indicating preferential targeting of this neuropil by afferents conveying information about ambient illumination...
October 31, 2017: BMC Biology
https://www.readbyqxmd.com/read/29099713/peculiairities-of-melatonin-effect-on-chonorhytmic-organization-of-kidney-acid-regulating-function-influenced-by-nitrogen-monoxide-synthesis-blockade-under-conditions-of-pineal-gland-hypofunction
#12
S Semenenko, I Tymofiychuk, L Boreyko, S Karatieieva, K Slobodian
The objective of research is to study the peculiarities of melatonin effect on chronorhythmic organization of the kidney acid-regulating function influenced by nitrogen monoxide (NO) synthesis blockade under conditions of pineal gland (PG) hypofunction. The experiments were conducted on 72 mature non-linear albino male rats with their body mass 0,15-0,18 kg. The animals were kept under vivarium conditions at a stable temperature and air humidity fed on a standard dietary intake. The control group included animals (n=36) kept under conditions of usual light regimen (12...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29099668/successful-conservative-treatment-of-massive-choroidal-relapse-in-2-retinoblastoma-patients-monitored-by-ultrasound-biomicroscopy-and-or-spectral-domain-optic-coherence-tomography
#13
Christina Stathopoulos, Marie-Claire Gaillard, Francesco Puccinelli, Philippe Maeder, Doris Hadjistilianou, Maja Beck-Popovic, Francis L Munier
PURPOSE: To report the occurrence and management of secondary choroidal infiltration in two retinoblastoma (rb) patients. METHODS: Fundus examination and imaging with spectral domain optical coherence tomography (SD-OCT), B-scan ultrasonography (B-scan), and ultrasound biomicroscopy (UBM). RESULTS: Case 1: A 19-month-old girl with multifocal unilateral group B rb pretreated with intravenous chemotherapy (IVC) was referred for further management...
November 3, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29095071/n-n-dimethyltryptamine-and-the-pineal-gland-separating-fact-from-myth
#14
David E Nichols
The pineal gland has a romantic history, from pharaonic Egypt, where it was equated with the eye of Horus, through various religious traditions, where it was considered the seat of the soul, the third eye, etc. Recent incarnations of these notions have suggested that N,N-dimethyltryptamine is secreted by the pineal gland at birth, during dreaming, and at near death to produce out of body experiences. Scientific evidence, however, is not consistent with these ideas. The adult pineal gland weighs less than 0...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29061489/corticosteroid-therapy-exacerbates-the-reduction-of-melatonin-in-multiple-sclerosis
#15
Shima Dokoohaki, Majid Ghareghani, Amir Ghanbari, Naser Farhadi, Kazem Zibara, Heibatollah Sadeghi
OBJECTIVES: Corticosteroid therapy is employed in multiple sclerosis (MS), a neurological abnormality characterized by an inflammatory process. Melatonin, a potent sleep-promoting and circadian phase regulatory hormone, is produced mainly in the pineal gland whose inhibition leads to sleep disturbances. METHODS: In this study, methylprednisolone (MP) corticosteroid treatment was used in an acute experimental autoimmune encephalomyelitis (EAE) rat model (intraperitoneal, 30 mg/kg) and in MS patients (intravenous, 1000 mg/day), followed by assessing melatonin serum levels...
October 20, 2017: Steroids
https://www.readbyqxmd.com/read/29057852/tumors-of-the-lateral-and-third-ventricle-surgical-management-and-outcome-analysis-in-42-cases
#16
Sherif M Elwatidy, Abdulrahman A Albakr, Abdullah A Al Towim, Safdar H Malik
OBJECTIVE: To discuss the clinical presentation, pathological diagnosis, and surgical outcome for a series of 42 consecutive patients treated for lateral and third ventricular tumors. METHODS: This is a retrospective series study conducted between 2001 and 2015 and included 42 patients (mean age: 25 years; range: 2 months-65 years) with lateral and third ventricle tumors surgically treated at King Khaled University Hospital, Riyadh, Kingdom of Saudi Arabia. Demographic, clinical, radiological, surgical, histopathological, and follow up data were analyzed...
October 2017: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29057188/pineal-gland-tumor-but-not-pinealoma-a-case-report
#17
Syeda Naqvi, Chintan Rupareliya, Abdullah Shams, Maria Hameed, Zabeen Mahuwala, Pirthvi Raj Giyanwani
The pineal gland is a small pinecone-shaped and functionally endocrine structure located in the epithalamus region. Developmentally, the pineal gland is considered as a part of the epithalamus. It plays a role in the entrainment of the circadian rhythms of an organism by producing melatonin, a functionally important hormone. Lesions of the pineal region are rare compared to other parts of the brain. A lesion may be tumorous or non-tumorous in nature. The most common lesions are tumors that are pineal parenchymal tumors (PPT) in origin...
August 18, 2017: Curēus
https://www.readbyqxmd.com/read/29053271/discovery-of-7-18-f-fluorotryptophan-as-a-novel-positron-emission-tomography-pet-probe-for-the-visualization-of-tryptophan-metabolism-in-vivo
#18
Boris D Zlatopolskiy, Johannes Zischler, Dominique Schäfer, Elizaveta A Urusova, Mehrab Guliyev, Olesia Bannykh, Heike Endepols, Bernd Neumaier
Tryptophan and its metabolites are involved in different physiological and pathophysiological processes. Consequently, positron emission tomography (PET) tracers addressing tryptophan metabolic pathways should allow the detection of different pathologies like neurological disorders and cancer. Herein we report an efficient method for the preparation of fluorotryptophans labeled in different positions with (18)F and their biological evaluation. 4-7-[(18)F]Fluorotryptophans ([(18)F]FTrps) were prepared according to a modified protocol of alcohol-enhanced Cu-mediated radiofluorination in 30-53% radiochemical yields...
November 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29053071/prevention-of-postoperative-visual-field-defect-after-the-occipital-transtentorial-approach-anatomical-study
#19
Satoshi Matsuo, Serhat Baydin, Abuzer Güngör, Erik H Middlebrooks, Noritaka Komune, Koji Iihara, Albert L Rhoton
OBJECTIVE A postoperative visual field defect resulting from damage to the occipital lobe during surgery is a unique complication of the occipital transtentorial approach. Though the association between patient position and this complication is well investigated, preventing the complication remains a challenge. To define the area of the occipital lobe in which retraction is least harmful, the surface anatomy of the brain, course of the optic radiations, and microsurgical anatomy of the occipital transtentorial approach were examined...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29051539/ophthalmological-symptoms-in-children-with-intracranial-cysts
#20
Anna Gotz Wieckowska, Lidia Glowka, Agata Brazert, Marta Pawlak
The purpose of this study was to perform an ophthalmological assessment in children with intracranial cysts and to assess the correlation between the occurrence of cysts and visual disorders. The documentation of 46 children with intracranial cysts, monitored by the Children's Outpatient Ophthalmology Clinic, Poznan, Poland was analysed. The best corrected visual acuity (BCVA), the alignment of the eyes, visual evoked potentials (VEP), comprehensive eye examination were performed in all patients. Additional ophthalmological tests were conducted to eliminate other causes of decreased visual acuity...
October 19, 2017: Scientific Reports
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