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https://www.readbyqxmd.com/read/29330934/melatonin-inhibits-the-proliferation-of-breast-cancer-cells-induced-by-bisphenol-a-via-targeting-estrogen-receptor-related-pathways
#1
Tianjiao Wang, Bowen Liu, Yanan Guan, Miaomiao Gong, Weiying Zhang, Jinjin Pan, Yanan Liu, Rui Liang, Yuhui Yuan, Lihong Ye
BACKGROUND: Background: Bisphenol A (BPA) is an estrogen-like chemical widely contained in daily supplies. There is evidence that environmental exposure to BPA could contribute to the development of hormone-related cancers. As is reported in numerous studies, melatonin, an endogenous hormone secreted by the pineal gland, could markedly inhibit estrogen-induced proliferation of breast cancer (BC) cells. In this study, we intended to reveal the effects of melatonin on BPA-induced proliferation of estrogen receptor-positive BC cells...
January 13, 2018: Thoracic Cancer
https://www.readbyqxmd.com/read/29330195/dicer1-gene-mutations-in-endocrine-tumors
#2
Michael Solarski, Fabio Rotondo, William Foulkes, John R Priest, Luis V Syro, Henriett Butz, Michael Cusimano, Kalman Kovacs
In this review, the importance of the DICER1 gene in the function of endocrine cells is discussed. There is conclusive evidence that DICER1 mutations play a crucial role in the development, progression, cell proliferation, therapeutic responsiveness and behavior of several endocrine tumors. We review the literature of DICER1 gene mutations in thyroid, parathyroid, pituitary, pineal gland, endocrine pancreas, paragangliomas, medullary, adrenocortical, ovarian, and testicular tumors. Although significant progress has been made during the last few years, much more work is needed to fully understand the significance of DICER1 mutations...
January 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29324398/epilepsy-in-patients-with-pineal-gland-cyst
#3
Jelena Bosnjak, Silva Soldo Butkovic, Snjezana Miskov, Lejla Coric, Ana Jadrijevic-Tomas, Vlatka Mejaski-Bosnjak
OBJECTIVE: The aim of the study is to describe types of epileptic seizures in patients with pineal gland cyst (PGC) and their outcome during follow up period (6-10 years). We wanted to determine whether patients with epilepsy differ in PGC volume and compression of the PGC on surrounding brain structures compared to patients with PGC, without epilepsy. PATIENTS AND METHODS: We analyzed prospectivelly 92 patients with PGC detected on magnetic resonance (MR) of the brain due to various neurological symptoms during the period 2006-2010...
January 4, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29320328/twenty-five-diagnoses-on-midline-images-of-the-brain-from-fetus-to-child-to-adult
#4
Asim F Choudhri, Harris L Cohen, Adeel Siddiqui, Vijay Pande, Ari M Blitz
Midsagittal images of the brain provide a wealth of anatomic information and may show abnormalities that are pathognomonic for particular diagnoses. Using an anatomy-based approach, the authors identify pertinent anatomic structures to serve as a checklist when evaluating these structures. Subregions evaluated include the corpus callosum, pituitary gland and sellar region, pineal gland and pineal region, brainstem, and cerebellum. The authors present 25 conditions with characteristic identifiable abnormalities at midsagittal imaging...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29312599/histopathological-molecular-clinical-and-radiological-characterization-of-rosette-forming-glioneuronal-tumor-in-the-central-nervous-system
#5
Chenlong Yang, Jingyi Fang, Guang Li, Shaowu Li, Tingting Ha, Jiangfei Wang, Bao Yang, Jun Yang, Yulun Xu
Objective: A rosette-forming glioneuronal tumor (RGNT) is a rare entity originally described in the fourth ventricle. Recently, RGNTs occurring in extraventricular sites and those with malignant behaviors have been reported. The purpose of this study was to analyze the clinicoradiological and histopathological features, therapeutic strategies, and outcomes of RGNTs. Methods: We enrolled 38 patients diagnosed with RGNTs pathologically between August 2009 and June 2016...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29298295/synchrotron-microtomography-of-a-nothosaurus-marchicus-skull-informs-on-nothosaurian-physiology-and-neurosensory-adaptations-in-early-sauropterygia
#6
Dennis F A E Voeten, Tobias Reich, Ricardo Araújo, Torsten M Scheyer
Nothosaurs form a subclade of the secondarily marine Sauropterygia that was well represented in late Early to early Late Triassic marine ecosystems. Here we present and discuss the internal skull anatomy of the small piscivorous nothosaur Nothosaurus marchicus from coastal to shallow marine Lower Muschelkalk deposits (Anisian) of Winterswijk, The Netherlands, which represents the oldest sauropterygian endocast visualized to date. The cranial endocast is only partially encapsulated by ossified braincase elements...
2018: PloS One
https://www.readbyqxmd.com/read/29297806/extension-of-the-known-host-range-of-intranuclear-coccidiosis-infection-in-three-captive-red-footed-tortoises-chelonoidis-carbonaria
#7
Justin M Stilwell, Natalie K Stilwell, Nicole I Stacy, James F X Wellehan, Lisa L Farina
The intranuclear coccidian parasite of Testudines (TINC) is an emerging pathogen of tortoises. Three captive red-footed tortoises ( Chelonoidis carbonaria) from an isolated collection presented with multiple acute, nonspecific clinical signs. One tortoise died and was diagnosed with intranuclear coccidiosis on histopathology with confirmation by quantitative polymerase chain reaction (qPCR). In addition to tissues where TINC has been previously described, coccidia were identified in the pineal gland, choroid plexus, and testicular Sertoli cells...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29280147/the-origins-of-the-circumventricular-organs
#8
REVIEW
Clemens Kiecker
The circumventricular organs (CVOs) are specialised neuroepithelial structures found in the midline of the brain, grouped around the third and fourth ventricles. They mediate the communication between the brain and the periphery by performing sensory and secretory roles, facilitated by increased vascularisation and the absence of a blood-brain barrier. Surprisingly little is known about the origins of the CVOs (both developmental and evolutionary), but their functional and organisational similarities raise the question of the extent of their relationship...
December 27, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29278521/the-pineal-gland-and-its-earliest-physiological-description
#9
Konstantinos Laios
No abstract text is available yet for this article.
July 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29277417/reprint-of-contrasting-effects-of-vortioxetine-and-paroxetine-on-pineal-gland-biochemistry-in-a-tryptophan-depletion-model-of-depression-in-female-rats
#10
M Franklin, N Hlavacova, Y Li, I Bermudez, A Csanova, C Sanchez, D Jezova
We studied the effects of the multi-modal antidepressant, vortioxetine and the SSRI, paroxetine on pineal melatonin and monoamine synthesis in a sub-chronic tryptophan (TRP) depletion model of depression based on a low TRP diet. Female Sprague-Dawley rats were randomised to groups a) control, b) low TRP diet, c) low TRP diet+paroxetine and d) low TRP diet+vortioxetine. Vortioxetine was administered via the diet (0.76mg/kg of food weight) and paroxetine via drinking water (10mg/kg/day) for 14days. Both drugs resulted in SERT occupancies >90%...
December 23, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29274449/proton-mrs-detection-of-high-lipid-levels-and-low-adc-is-characteristics-of-germinoma
#11
Fumiyuki Yamasaki, Yasuyuki Kinoshita, Takeshi Takayasu, Satoshi Usui, Manish Kolakshyapati, Motoki Takano, Sayuru Tsuyuguchi, Vishwa Jeet Amatya, Yuji Akiyama, Yukio Takeshima, Kazuhiko Sugiyama, Kaoru Kurisu
BACKGROUND: The differentiation of germinoma from other tumors by conventional MRI can be very difficult. The purpose of our study was to determine if proton magnetic resonance spectroscopy and diffusion-weighted imaging could give additional information for definitive diagnosis of germinoma. MATERIALS AND METHODS: Our institutional review board approved this retrospective study. We reviewed the images of 26 patients with histologically confirmed germinoma who were treated in our institution between 2003 and 2016...
December 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29273324/temporal-expression-of-c-fos-and-genes-coding-for-neuropeptides-and-enzymes-of-amino-acid-and-amine-neurotransmitter-biosynthesis-in-retina-pineal-and-hypothalamus-of-a-migratory-songbird-evidence-for-circadian-rhythm-dependent-seasonal-responses
#12
Ila Mishra, Devraj Singh, Vinod Kumar
This study investigated whether, in photoperiodic songbirds, the circadian pacemaker system (CPS) connects to the seasonal photoperiodic responses, by changes at transcriptional level in the level and 24-h rhythm of its constituent neurotransmitters. We used blackheaded buntings (Emberiza melanocephala), which exhibits distinct seasonal states in captivity under appropriate photoperiods and hence served as a useful model system. Under short days, buntings remain in the photosensitive state (winter phenotype: non-migratory, non-breeding)...
December 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/29258947/a-novel-method-to-measure-the-tentorial-angle-and-the-implications-on-surgeries-of-the-pineal-region
#13
Hasan R Syed, Walter C Jean
OBJECTIVE: There is no standard way to define the angle of the tentorium. The current trend to use the Twining line to define this angle has significant pitfalls. The goal of the current study is to provide a new and accurate way to measure the "tentorial angle," and demonstrate its impact on surgeries of the pineal region. METHODS: A new technique (n-angle) to measure the tentorial angle is introduced using the floor of the fourth ventricle and the torcula. Comparisons to older techniques were made to illustrate reliability...
December 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29249587/correlations-of-serum-cyclophilin-a-and-melatonin-concentrations-with-hypertension-induced-left-ventricular-hypertrophy
#14
Hongyan Su, Tongshuai Chen, Jingyuan Li, Jie Xiao, Shujian Wang, Xiaobin Guo, Peili Bu
BACKGROUND AND AIMS: Cyclophilin A (CyPA) is an abundantly expressed pro-inflammatory cytokine and a major secreted oxidative stress-induced factor (SOXF). Melatonin is an important chronobiological regulatory molecule that is mainly released from the pineal gland and exerts antioxidant effects by acting as a radical scavenger. Based on accumulating evidence, both CyPA and melatonin play important roles in cardiovascular diseases. However, further investigations are required to determine whether CyPA and melatonin are associated with hypertension-induced left ventricular hypertrophy (LVH)...
December 14, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/29239123/seeing-the-light-to-change-colour-an-evolutionary-perspective-on-the-role-of-melanopsin-in-neuroendocrine-circuits-regulating-light-mediated-skin-pigmentation
#15
REVIEW
Gabriel E Bertolesi, Sarah McFarlane
Melanopsin photopigments, Opn4x and Opn4m, were evolutionary selected to "see the light" in systems that regulate skin colour change. In this review, we analyse the roles of melanopsins, and how critical evolutionary developments, including the requirement for thermoregulation and ultraviolet protection, the emergence of a background adaptation mechanism in land-dwelling amphibian ancestors and the loss of a photosensitive pineal gland in mammals, may have helped sculpt the mechanisms that regulate light-controlled skin pigmentation...
December 14, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29224667/the-hormone-melatonin-animal-studies
#16
REVIEW
P Pevet, P Klosen, M P Felder-Schmittbuhl
The Melatonin (MLT), secreted rhythmically by the pineal, is an efferent hormonal signal of the circadian clock. MLT presents overall pleitropic effects but it is the role of MLT as a hormonal circadian signal which is the best documented. MLT-receptors are present in numerous structures/organs and the MLT is now considered as an endogenous synchronizer within the circadian system. The presence of MLT-receptors within the circadian clock, explains that exogenous MLT is a chronobiotic drug. Trials in humans, have confirmed the efficacy of MLT in circadian rhythm disorders...
December 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29217260/ontogenesis-of-the-pinealo-retinal-neuronal-connection-in-albino-rats
#17
Ágnes Csáki, Viktória Vereczki, Ákos Lukáts, Zsolt Boldogkői, Anna Sebestyén, Zita Puskár, Katalin Köves
It was accepted for a long time that in mammals there is only retinofugal neuronal connection between the eye and the pineal body (PB). In our previous paper we described that nerve cells were present in hamster PB and these neurons could establish a reverse connection with the retina through a transsynaptic pathway. In adult albino rats neuronal perikarya were not found. In this present experiment it was examined whether the lack of these nerve cells in the PB of adult rats is the result of an apoptotic phenomenon or the lack of migration during the fetal period...
December 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29207116/melatonin-exerts-an-inhibitory-effect-on-insulin-gene-transcription-via-mtnr1b-and-the-downstream-raf%C3%A2-1-erk-signaling-pathway
#18
Yanliang Li, Huihui Wu, Naijia Liu, Xinyi Cao, Zhen Yang, Bin Lu, Renming Hu, Xuanchun Wang, Jie Wen
The pineal hormone melatonin influences the secretion of insulin by pancreatic islets via the G‑protein‑coupled melatonin receptors 1 and 2 that are expressed in pancreatic β‑cells. Genome‑wide association studies indicate that melatonin receptor 1B (MTNR1B) single nucleotide polymorphisms are tightly associated with type 2 diabetes mellitus (T2DM). However, the underlying mechanism is unclear. Raf‑1 serves a critical role in the mitogen‑activated protein kinase (MAPK) pathways in β‑cell survival and proliferation and, therefore, may be involved in the mechanism by which melatonin impacts on T2DM through MTNR1B...
December 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29206172/melatonin-efficacy-in-obese-leptin-deficient-mice-heart
#19
Alessandra Stacchiotti, Gaia Favero, Lorena Giugno, Igor Golic, Aleksandra Korac, Rita Rezzani
Cardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria and sarcoplasmic reticulum necessary for calcium flux and contraction. Melatonin, important indoleamine secreted by the pineal gland during darkness, also has important cardioprotective properties. We designed the present study to define morphological and ultrastructural changes in cardiomyocytes and mainly in mitochondria of an animal model of obesity (ob/ob mice), when treated orally or not with melatonin at 100 mg/kg/day for 8 weeks (from 5 up to 13 week of life)...
December 5, 2017: Nutrients
https://www.readbyqxmd.com/read/29200002/metformin-and-melatonin-inhibit-dmba-induced-mammary-tumorigenesis-in-rats-fed-a-high-fat-diet
#20
Bianka Bojková, Karol Kajo, Terézia Kisková, Peter Kubatka, Pavol Žúbor, Peter Solár, Martin Péč, Marián Adamkov
The data from in-vitro and in-vivo studies show that both peroral antidiabetic metformin (MF) and pineal hormone melatonin (MT) inhibit the growth of many cancers, including breast cancer. However, most in-vivo studies used standard-type diet with low fat content. Therefore, in this study, we evaluated the chemopreventive effect of MF and MT in an in-vivo model of breast cancer in rats on a high-fat diet (10% of total fat). Mammary carcinogenesis was induced by 7,12-dimethylbenz[a]anthracene (DMBA) in female Sprague-Dawley rats...
December 1, 2017: Anti-cancer Drugs
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