Brent W Stewart, Michael L Keaser, Hwiyoung Lee, Sarah M Margerison, Matthew A Cormie, Massieh Moayedi, Martin A Lindquist, Shuo Chen, Brian N Mathur, David A Seminowicz
Aberrant cognitive network activity and cognitive deficits are established features of chronic pain. However, the nature of cognitive network alterations associated with chronic pain and their underlying mechanisms require elucidation. Here, we report that the claustrum, a subcortical nucleus implicated in cognitive network modulation, is activated by acute painful stimulation and pain-predictive cues in healthy participants. Moreover, we discover pathological activity of the claustrum and a region near the posterior inferior frontal sulcus of the right dorsolateral prefrontal cortex (piDLPFC) in migraine patients during acute pain and cognitive task performance...
April 8, 2024: Current Biology: CB