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https://www.readbyqxmd.com/read/28636261/characteristics-of-corneal-biomechanical-responses-detected-by-a-non-contact-scheimpflug-based-tonometer-in-eyes-with-glaucoma
#1
Younhea Jung, Hae-Young L Park, Hee Jung Yang, Chan Kee Park
PURPOSE: To determine the corneal biomechanical properties in eyes with glaucoma using a non-contact Scheimpflug-based tonometer. METHODS: Corneal biomechanical responses were examined using a non-contact Scheimpflug-based tonometer. The tonometer parameters of the normal control group (n = 75) were compared with those of the glaucoma group (n = 136), including an analysis of glaucoma subgroups categorized by visual field loss. RESULTS: After adjusting for potential confounding factors, including the intraocular pressure (IOP), central corneal thickness (CCT), age and axial length, the deformation amplitude was smaller in the glaucoma group (1...
June 21, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28634671/venous-thromboembolism-is-an-independent-predictor-of-mortality-among-patients-with-gastric-cancer
#2
Harry E Fuentes, D M Oramas, L H Paz, Y Wang, X A Andrade, A J Tafur
BACKGROUND: Venous thromboembolism (VTE) is an independent predictor of death among patients with cancer. Patients with gastric cancer (GC) are at higher risk for VTE when compared to other solid tumors, and if one considers its prevalence, GC may be responsible for one of the highest incidences of cancer-associated thrombosis. The impact of VTE on mortality is not well defined among patients with GC. AIM: The aim of this study is to measure the impact of VTE as independent predictor of GC mortality...
June 21, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28634654/improvement-in-latent-variable-indirect-response-modeling-of-multiple-categorical-clinical-endpoints-application-to-modeling-of-guselkumab-treatment-effects-in-psoriatic-patients
#3
Chuanpu Hu, Bruce Randazzo, Amarnath Sharma, Honghui Zhou
Exposure-response modeling plays an important role in optimizing dose and dosing regimens during clinical drug development. The modeling of multiple endpoints is made possible in part by recent progress in latent variable indirect response (IDR) modeling for ordered categorical endpoints. This manuscript aims to investigate the level of improvement achievable by jointly modeling two such endpoints in the latent variable IDR modeling framework through the sharing of model parameters. This is illustrated with an application to the exposure-response of guselkumab, a human IgG1 monoclonal antibody in clinical development that blocks IL-23...
June 20, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28634619/implementation-of-li-rads-into-a-radiological-practice
#4
REVIEW
Stefan T Siedlikowski, Ania Z Kielar, Eleanor L Ormsby, Bijan Bijan, Christopher Kagay
Since its introduction in 2011, Liver Imaging Reporting and Data System (LI-RADS) has become an increasingly utilized method for radiologists to categorize lesions for hepatocellular carcinoma (HCC) in patients at risk (American College of Radiology, www.acr.org/quality-safety/resources/lirads 2016). This overview article presents insight into methods of incorporating LI-RADS into an existing clinical practice, highlighting concrete ways to establish this system as a mainstay in any radiologist's evidence-based armamentarium...
June 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28634497/weighted-polynomial-approximation-for-automated-detection-of-inspiratory-flow-limitation
#5
Sheng-Cheng Huang, Hao-Yu Jan, Tieh-Cheng Fu, Wen-Chen Lin, Geng-Hong Lin, Wen-Chi Lin, Cheng-Lun Tsai, Kang-Ping Lin
Inspiratory flow limitation (IFL) is a critical symptom of sleep breathing disorders. A characteristic flattened flow-time curve indicates the presence of highest resistance flow limitation. This study involved investigating a real-time algorithm for detecting IFL during sleep. Three categories of inspiratory flow shape were collected from previous studies for use as a development set. Of these, 16 cases were labeled as non-IFL and 78 as IFL which were further categorized into minor level (20 cases) and severe level (58 cases) of obstruction...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28634305/data-driven-extraction-of-a-nested-model-of-human-brain-function
#6
Taylor Bolt, Jason S Nomi, B T Thomas Yeo, Lucina Q Uddin
Decades of cognitive neuroscience research have revealed two basic facts regarding task-driven brain activation patterns. First, distinct patterns of activation occur in response to different task demands. Second, a superordinate, dichotomous pattern of activation/de-activation, is common across a variety of task demands. We explore the possibility that a hierarchical model incorporates these two observed brain activation phenomena into a unifying framework. We apply a latent variable approach, exploratory bi-factor analysis, to a large set of human (both sexes) brain activation maps (n = 108) encompassing cognition, perception, action and emotion behavioral domains, to determine the potential existence of a nested structure of factors that underlies a variety of commonly observed activation patterns...
June 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28634162/linking-the-content-to-demographic-reach-of-online-advertising-of-electronic-nicotine-delivery-systems
#7
David S Timberlake, Dmitriy Nikitin, Jennifer Garcia-Cano, Samantha Cino, Margarita Savkina, Cornelia Pechmann
INTRODUCTION: Recent studies have separately examined the content and demographic reach of the advertising of electronic nicotine delivery systems (ENDS). No study to our knowledge has linked the two in investigating whether racial/ethnic groups are differentially exposed to the comparative messages conveyed in online ENDS advertisements. METHODS: 932 unique ENDS advertisements (6311 total), which were posted on 3435 websites between December, 2009 and October, 2015, were categorized as either comparative or non-comparative with respect to the traditional cigarette...
June 20, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28634136/tongxie-formula-reduces-symptoms-of-irritable-bowel-syndrome
#8
Heng Fan, Liang Zheng, Yaoliang Lai, Weimin Lu, Zhixiang Yan, Qi Xiao, Baiwen Li, Min Tang, Dawei Huang, Yuanyuan Wang, Zhen Li, Yuwei Mei, Zhengyan Jiang, Xingxing Liu, Qing Tang, Dongmei Zuo, Jingyi Ye, Yongqiang Yang, Huisuo Huang, Zongxiang Tang, Jun Xiao
BACKGROUND & AIMS: Irritable bowel syndrome (IBS) is the most common chronic gastrointestinal disorder, yet few drugs are effective in reducing symptoms. Approximately 50% of patients with IBS attempt herbal therapy at least once. We performed a randomized controlled trial to compare the efficacy of the herb formulation tongxie vs placebo or pinaverium (an antispasmodic agent) in reducing symptoms of IBS. METHODS: We performed a trial of 1044 adult patients with IBS (based on Rome III criteria) at 5 hospitals in China, from August 2012 through January 2015...
June 17, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28634098/sepsis-within-30-days-of-geriatric-hip-fracture-surgery
#9
Daniel D Bohl, Stephanie E Iantorno, Bryan M Saltzman, Matthew W Tetreault, Brian Darrith, Craig J Della Valle
BACKGROUND: Sepsis after hip fracture typically develops from one of the 3 potential infectious sources: urinary tract infection (UTI), pneumonia, and surgical site infection (SSI). The purpose of this investigation is to determine (1) the proportion of cases of sepsis that arises from each of these potential infectious sources; (2) baseline risk factors for developing each of the potential infectious sources; and (3) baseline risk factors for developing sepsis. METHODS: The National Surgical Quality Improvement Program database was searched for geriatric patients (aged >65 years) who underwent surgery for hip fracture during 2005-2013...
May 19, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28634047/the-study-of-the-intervertebral-disc-microstructure-in-matured-rats-with-diffusion-kurtosis-imaging
#10
Li Li, Wenzhen Zhu, Weiwei Chen, Jicheng Fang, Jing Li
OBJECTIVES: The aim of this study was to use DKI to detect the microstructural change of the discs in matured normal rats. METHODS: Total 24 normal SD rats (12 males/12 females) underwent DWI/DKI and T2 sequences with a 3T MRI scanner to get the values of ADC, FA, MD, Da, Dr, MK, Ka and Kr. The discs were categorized using a five-grade degeneration grading system in the T2-images. The height of the discs and the parameters in DWI/DKI were measured to compare between the different grades and sexes...
June 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28634042/routine-ultrasound-quality-assurance-in-a-multi-unit-radiology-department-a-retrospective-evaluation-of-transducer-failures
#11
Anne-Mari Vitikainen, Juha I Peltonen, Eija Vartiainen
The importance of quality assurance (QA) in medical ultrasound (US) has been widely recognized and recommendations concerning technical QA have been published over the years. However, the demonstrated impact of a properly working QA protocol on clinical routine has been scarce. We investigated the transducer write-off causes for a 5-y period in a multi-unit radiology department with an annual average of 230 transducers in demanding diagnostic use. The transducer faults and the initial observers of the faults leading to transducer write-offs were traced and categorized...
June 17, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28634018/distribution-subtype-population-and-ige-positivity-of-mast-cells-in-chronic-rhinosinusitis-with-nasal-polyps
#12
Shintaro Baba, Kenji Kondo, Maho Suzukawa, Ken Ohta, Tatsuya Yamasoba
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) has been categorized into 2 subtypes in the Asian population: eosinophilic chronic rhinosinusitis (ECRS; similar to CRSwNP in Western countries) and non-ECRS (characterized by inflammation dominated by T-helper cell type 1). The pathogenesis of CRSwNP and the role of mast cells are poorly understood. OBJECTIVE: To investigate the distribution, phenotypes, and immunoglobulin E (IgE) positivity of mast cells in these 2 subtypes of CRSwNP...
June 17, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28633884/differences-in-practice-characteristics-between-male-and-female-chiropractors-in-switzerland
#13
Regina Vollenweider, Cynthia K Peterson, B Kim Humphreys
OBJECTIVES: A total of 75% of the chiropractic medicine students in the new program at the University of Zürich are women, which is in stark contrast to the traditional ratio of chiropractors in Switzerland, where 75% have been men. Therefore, the purpose of this study was to compare work behaviors between female and male chiropractors relating to workload, patient variety, and chiropractic treatment techniques. METHODS: This is a secondary analysis of data from the Swiss Job Analysis 2009 study...
June 17, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28633853/multi-objective-optimization-of-oxidative-desulfurization-in-a-sono-photochemical-airlift-reactor
#14
Jamshid Behin, Negin Farhadian
Response surface methodology (RSM) was employed to optimize ultrasound/ultraviolet-assisted oxidative desulfurization in an airlift reactor. Ultrasonic waves were incorporated in a novel-geometry reactor to investigate the synergistic effects of sono-chemistry and enhanced gas-liquid mass transfer. Non-hydrotreated kerosene containing sulfur and aromatic compounds was chosen as a case study. Experimental runs were conducted based on a face-centered central composite design and analyzed using RSM. The effects of two categorical factors, i...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633781/beaming-in-charcot-arthropathy-intramedullary-fixation-for%C3%A2-complicated-reconstructions-a-cadaveric-study
#15
Corey M Fidler, Benjamin C Watson, Christopher W Reb, Christopher F Hyer
In the modern treatment of Charcot neuroarthropathy, beam screw fixation is an alternative to plate and screw fixation. Exposure is minimized for implantation, and this technique supports the longitudinal columns of the foot as a rigid load-sharing construct. A published data review identified a paucity of data regarding metatarsal intramedullary canal morphology relevant to beam screw fixation. The purpose of the present study was to describe metatarsal diaphyseal morphology qualitatively and quantitatively in an effort to provide data that can be used by surgeons when selecting axially based intramedullary fixation...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633721/allergic-and-non-allergic-rhinitis-are-common-in-obstructive-sleep-apnea-but-not-associated-with-disease-severity
#16
Ming Zheng, Xiangdong Wang, Siqi Ge, Ying Gu, Xiu Ding, Yuhuan Zhang, Jingying Ye, Luo Zhang
STUDY OBJECTIVES: Several studies have suggested that rhinitis contributes to the pathogenesis of obstructive sleep apnea (OSA). We aimed to investigate the prevalence and influence of allergic rhinitis (AR) and non-allergic rhinitis (NAR) on severity of OSA. METHODS: Two hundred forty patients with OSA confirmed by standardized polysomnography were assessed for presence of AR and NAR, using validated questionnaires and skin prick tests. Data comparison was carried out by using chi-square test, analysis of variance, and least significant difference test...
June 16, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28633691/dietary-gap-assessment-an-approach-for-evaluating-whether-a-country-s-food-supply-can-support-healthy-diets-at-the-population-level
#17
Edye M Kuyper, Reina Engle-Stone, Joanne E Arsenault, Mary Arimond, Katherine P Adams, Kathryn G Dewey
OBJECTIVE: Dietary diversity, and in particular consumption of nutrient-rich foods including fruits, vegetables, nuts, beans and animal-source foods, is linked to greater nutrient adequacy. We developed a 'dietary gap assessment' to evaluate the degree to which a nation's food supply could support healthy diets at the population level. Design/Setting In the absence of global food-based dietary guidelines, we selected the Dietary Approaches to Stop Hypertension (DASH) diet as an example because there is evidence it prevents diet-related chronic disease and supports adequate micronutrient intakes...
June 21, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28633585/lipoprotein-a-activated-immunity-insulin-resistance-and-new-onset-diabetes
#18
Ayşem Kaya, Altan Onat, Hüsniye Yüksel, Günay Can, Murat Yüksel, Evin Ademoğlu
OBJECTIVES: Some evidence suggests that serum lipoprotein[Lp](a) may be inversely linked to type-2 diabetes. We aimed to determine in nondiabetic people the relationship of serum [Lp](a) with insulin resistance and new-onset diabetes (NOD). MATERIALS AND METHODS: Population-based middle-aged adults (n=1685) were categorized by fasting glucose and stratified to gender, having excluded prevalent diabetic subjects. NOD (n=90) occurred over a median 5 years' follow-up...
June 21, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28633449/night-work-as-a-risk-factor-of-future-disability-pension-due-to-musculoskeletal-diagnoses-a-prospective-cohort-study-of-swedish-twins
#19
Sanna Kärkkäinen, Annina Ropponen, Jurgita Narusyte, Lisa Mather, Torbjörn Åkerstedt, Karri Silventoinen, Ellenor Mittendorfer-Rutz, Pia Svedberg
Background: This study investigated the associations between night work, sleep and disability pension (DP) due to musculoskeletal disorders (MSD), while controlling for several confounding factors including both genetic factors and shared family background. Methods: The study sample consisted of 27 165 Swedish twin individuals born in 1935-58 with comprehensive survey data on sociodemographic, health and lifestyle factors. Night work was assessed as years of working hours at night at least every now and then, and categorized into 'not at all, 1-10 years and over 10 years'...
June 19, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28633321/places-in-the-brain-bridging-layout-and-object-geometry-in-scene-selective-cortex
#20
Moira R Dillon, Andrew S Persichetti, Elizabeth S Spelke, Daniel D Dilks
Diverse animal species primarily rely on sense (left-right) and egocentric distance (proximal-distal) when navigating the environment. Recent neuroimaging studies with human adults show that this information is represented in 2 scene-selective cortical regions-the occipital place area (OPA) and retrosplenial complex (RSC)-but not in a third scene-selective region-the parahippocampal place area (PPA). What geometric properties, then, does the PPA represent, and what is its role in scene processing? Here we hypothesize that the PPA represents relative length and angle, the geometric properties classically associated with object recognition, but only in the context of large extended surfaces that compose the layout of a scene...
June 13, 2017: Cerebral Cortex
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