Yuan-Yuan Zhang, Ying Xia, Hong-Li Guo, Ya-Hui Hu, Xiao-Yi Wen, Jing Chen, Xiao-Peng Lu, Shan-Shan Wang, Jin-Chun Qiu, Feng Chen
Oral anti-seizure medications (ASMs) is the preferred option for the clinical treatment of epilepsy. Therapeutic Drug Monitoring (TDM) has become an important means of individualized treatment of epilepsy. A sensitive, accurate and rapid LC-ESI-MS/MS method was developed and validated for the simultaneous determination of 15 ASMs in human plasma (carbamazepine, gabapentin, prebaglin, phenytoin, zonisamide, oxcarbazepine, tiagabine, lamotrigine, topiramate, phenobarbital, lacosamide, primidone, 10,11-dihydro-10-hydroxycarbamazepine, ethosuximide, and levetiracetam)...
August 23, 2022: Biomedical Chromatography: BMC