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Keywords Therapeutic drug monitoring le...

Therapeutic drug monitoring levetiracetam

https://read.qxmd.com/read/36753020/rectal-use-of-levetiracetam-best-practice-report-for-a-stepwise-approach-for-sustainable-off-label-decision-making-and-treatment
#21
JOURNAL ARTICLE
Constanze Rémi, Alina Hermann, Elisabeth Krull, Franziska Ockert-Schön, Jan Rémi
Off-label drug use is common practice in palliative care. It may pose a risk to the patient and benefit should outweigh harm. A decision and documentation aid for off-label use was developed to support practitioners in clinical practice off-label use. Using the example of the rectal administration of levetiracetam in three patient cases, the utilisation and benefits of the decision and documentation aid are presented and discussed. The rectal administration of levetiracetam clearly is an experimental treatment approach with little underlying evidence...
February 8, 2023: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/36695249/lessons-learnt-from-therapeutic-drug-monitoring-of-levetiracetam
#22
EDITORIAL
N N Rege
No abstract text is available yet for this article.
2023: Journal of Postgraduate Medicine
https://read.qxmd.com/read/36302342/validation-of-conversion-factors-for-therapeutic-drug-monitoring-of-lacosamide-lamotrigine-and-levetiracetam-in-dried-capillary-blood
#23
JOURNAL ARTICLE
Anne Hagemann, Dennis Klimpel, Elisabeth Schmitter, Christian G Bien, Bertin Dufaux, Theodor W May, Christian Brandt
BACKGROUND: Estimation of serum concentrations of antiseizure medications (ASMs) based on dried capillary blood is an alternative method for therapeutic drug monitoring of epilepsy. The aim of this study was to validate the conversion factors for lacosamide (LCM), lamotrigine (LTG), and levetiracetam (LEV), which were determined in an independent patient sample in a previous study, and identify the most accurate conversion method (simple ratio, regression). METHODS: Venous and capillary blood samples were collected from adult inpatients with epilepsy treated with LCM (n=25), LTG (n=27), and/or LEV (n=29) before the morning dose (T1) and approximately 2 h after (T2)...
October 26, 2022: Therapeutic Drug Monitoring
https://read.qxmd.com/read/36272308/extensive-pharmacokinetic-variability-of-levetiracetam-%C3%A2-are-doctors-aware
#24
JOURNAL ARTICLE
Maria de Toledo, Elisa de la Fuente, Carmen Ramos, Raquel Ferreiros-Martinez, Ines Muro, Alba Vieira Campos, M Paula de Toledo, Alfonso Lagares, Monica Sobrado, Maria C Ovejero-Benito
INTRODUCTION: Levetiracetam was presented as a drug with linear pharmacokinetics. There is currently evidence on its extensive pharmacokinetic variability in real clinical practice. OBJECTIVE: To describe levetiracetam pharmacokinetic variability in patients with epilepsy in real clinical practice. To evaluate the effect on levetiracetam levels of gender, age, renal function, and polytherapy. To describe how clinicians prescribe based on age and co-medication. METHODS: Retrospective analysis of epilepsy patients treated with levetiracetam for whom plasma levels were available...
September 29, 2022: Epilepsy Research
https://read.qxmd.com/read/36257713/association-of-levetiracetam-concentration-with-seizure-frequency-in-pregnant-women-with-epilepsy
#25
JOURNAL ARTICLE
Meike Schelhaas, Ilse Wegner, Mireille Edens, Elisabeth Wammes-Van Der Heijden, Daniel Touw, Peter Ter Horst
BACKGROUND AND OBJECTIVES: Pharmacologic treatment of epilepsy in pregnant women is balancing between risks for the mother and fetus. Levetiracetam (LEV) is considered to be safe during pregnancy because of its low teratogenic potential and lack of drug-drug interaction with other antiseizure medications (ASMs). Recent studies have shown decline of ASM concentrations during pregnancy because of physiologically based pharmacokinetic changes. In this study, we established this decrease in LEV concentration during pregnancy...
January 10, 2023: Neurology
https://read.qxmd.com/read/36255019/therapeutic-drug-monitoring-of-levetiracetam-method-validation-using-high-performance-liquid-chromatography-ultraviolet-detector-technique-and-usefulness-in-patient-care-setting
#26
JOURNAL ARTICLE
R P Munshi, J V Vishwakarma, N R Gawde
OBJECTIVES: To develop and validate a modified HPLC-UV method for the estimation of serum levetiracetam levels and to assess the usefulness of serum levetiracetam estimation in epileptic patients. MATERIALS AND METHODS: Modification of a previously existing HPLC-UV method was performed using liquid- liquid phase extraction and processing using reverse phase analytic HPLC-UV detector technique followed by method validation. Serum samples of patients attending our hospital's Therapeutic Drug Monitoring Outpatient Department services were analyzed for levetiracetam levels using the study method...
October 12, 2022: Journal of Postgraduate Medicine
https://read.qxmd.com/read/36140228/clinical-application-of-pharmacokinetics-to-appraise-adherence-to-levetiracetam-in-portuguese-epileptic-patients
#27
JOURNAL ARTICLE
Rui Silva, Joana Bicker, Anabela Almeida, Andreia Carona, Ana Silva, Francisco Sales, Isabel Santana, Amílcar Falcão, Ana Fortuna
Adherence to antiseizure drug treatment determines its effectiveness and safety, and consequently affects patients' quality of life. Herein, we assessed adherence to levetiracetam in Portuguese patients with refractory epilepsy ( n = 115), with resort to a pharmacokinetic drug monitoring approach. The pharmacokinetic parameters of levetiracetam in each patient were determined in steady-state while admitted to the hospital. Then, adherence was assessed by comparing the plasma concentration of the drug observed on the first day of hospitalization with the predicted plasma concentration, considering previously determined pharmacokinetic parameters...
August 30, 2022: Biomedicines
https://read.qxmd.com/read/36027943/evaluation-of-serum-and-rapid-serum-separator-collection-tubes-for-therapeutic-drug-assays
#28
JOURNAL ARTICLE
Kyana Y Garza, Jamie Carter, April Mercer, Pamela Jarrar, Jonathan Martin, Shaquawna Daughtry, Aaron Mahomes, Claire E Knezevic
Appropriate specimen collection and storage is essential to preserve sample integrity and ensure accurate test results. The default collection containers for blood drug concentrations are tubes without gel separators to avoid possible drug adsorption. However, routine chemistry tests are generally collected in gel separator tubes due to their convenient transport and processing; collection of an additional gel-free tube is often required for drug measurements. Citrated whole blood was pooled, spiked with drug, and transferred to three tubes (red, SST gold, RST orange) containing calcium chloride...
August 23, 2022: Clinical Biochemistry
https://read.qxmd.com/read/35997075/an-lc-esi-ms-ms-assay-for-the-therapeutic-drug-monitoring-of-15-anti-seizure-medications-in-plasma-of-children-with-epilepsy
#29
JOURNAL ARTICLE
Yuan-Yuan Zhang, Ying Xia, Hong-Li Guo, Ya-Hui Hu, Xiao-Yi Wen, Jing Chen, Xiao-Peng Lu, Shan-Shan Wang, Jin-Chun Qiu, Feng Chen
Oral anti-seizure medications (ASMs) is the preferred option for the clinical treatment of epilepsy. Therapeutic Drug Monitoring (TDM) has become an important means of individualized treatment of epilepsy. A sensitive, accurate and rapid LC-ESI-MS/MS method was developed and validated for the simultaneous determination of 15 ASMs in human plasma (carbamazepine, gabapentin, prebaglin, phenytoin, zonisamide, oxcarbazepine, tiagabine, lamotrigine, topiramate, phenobarbital, lacosamide, primidone, 10,11-dihydro-10-hydroxycarbamazepine, ethosuximide, and levetiracetam)...
August 23, 2022: Biomedical Chromatography: BMC
https://read.qxmd.com/read/35876114/neonatal-seizures-treatment-based-on-conventional-multichannel-eeg-monitoring-an-overview-of-therapeutic-options
#30
JOURNAL ARTICLE
Isotta Guidotti, Licia Lugli, Luca Ori, Maria Federica Roversi, Elisa Della Casa Muttini, Luca Bedetti, Marisa Pugliese, Francesca Cavalleri, Francesca Stefanelli, Fabrizio Ferrari, Alberto Berardi
INTRODUCTION: Seizures are the main neurological emergency during the neonatal period and are mostly acute and focal. The prognosis mainly depends on the underlying etiology. Conventional multichannel video-electroencephalographic (cEEG) monitoring is the gold standard for diagnosis, but treatment remains a challenge. AREAS COVERED: : This review, based on PubMed search over the last 4 decades, focuses on the current treatment options for neonatal seizures based on cEEG monitoring...
July 25, 2022: Expert Review of Neurotherapeutics
https://read.qxmd.com/read/35745860/pharmacogenetic-analysis-of-voriconazole-treatment-in-children
#31
JOURNAL ARTICLE
Romy Tilen, Paolo Paioni, Aljoscha N Goetschi, Roland Goers, Isabell Seibert, Daniel Müller, Julia A Bielicki, Christoph Berger, Stefanie D Krämer, Henriette E Meyer Zu Schwabedissen
Voriconazole is among the first-line antifungal drugs to treat invasive fungal infections in children and known for its pronounced inter- and intraindividual pharmacokinetic variability. Polymorphisms in genes involved in the metabolism and transport of voriconazole are thought to influence serum concentrations and eventually the therapeutic outcome. To investigate the impact of these genetic variants and other covariates on voriconazole trough concentrations, we performed a retrospective data analysis, where we used medication data from 36 children suffering from invasive fungal infections treated with voriconazole...
June 17, 2022: Pharmaceutics
https://read.qxmd.com/read/35680010/association-of-plasma-levetiracetam-concentration-mgmt-methylation-and-sex-with-survival-of-chemoradiotherapy-treated-glioblastoma-patients
#32
JOURNAL ARTICLE
Federico Cucchiara, Giacomo Luci, Noemi Giannini, Filippo Sean Giorgi, Paola Orlandi, Marta Banchi, Antonello Di Paolo, Francesco Pasqualetti, Romano Danesi, Guido Bocci
Glioblastoma multiforme (GBM) is an aggressive brain tumor, often occurring with seizures managed with antiepileptic drugs, such as levetiracetam (LEV). This study is aimed at associating progression-free survival (PFS) and overall survival (OS) of GBM patients with LEV plasma concentration, MGMT promoter methylation, and sex. In this retrospective, non-interventional, and explorative clinical study, GBM patients underwent surgery and/or radiotherapy and received LEV during adjuvant temozolomide (TMZ) treatment...
July 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/35619263/optimization-of-therapy-in-patients-with-epilepsy-and-psychiatric-comorbidities-key-points
#33
JOURNAL ARTICLE
Francesco Pisani, Laura Rosa Pisani, Maria Antonietta Barbieri, Jose de Leon, Edoardo Spina
Psychiatric disorder comorbidity in patients with epilepsy (PWE) is very frequent with a mean percentage prevalence of up to 50% and even higher. Such a high frequency suggests that epilepsy and psychiatric disorders might share common pathological pathways. Various aspects contribute in making the matter very complex from a therapeutic point of view. Some antiseizure medications (ASMs), namely valproic acid, carbamazepine, and lamotrigine, have mood-stabilising effects and are routinely used for the treatment of bipolar disorder in patients who do not have epilepsy...
2023: Current Neuropharmacology
https://read.qxmd.com/read/35609355/efficacy-tolerability-and-pharmacokinetic-variability-of-brivaracetam-in-adults-with-difficult-to-treat-epilepsy
#34
JOURNAL ARTICLE
Torleiv Svendsen, Eylert Brodtkorb, Hanna L Linge, Margrete L Burns, Svein I Johannessen, Karl O Nakken, Morten I Lossius, Cecilie Johannessen Landmark
PURPOSE: Brivaracetam (BRV) is one of our latest antiseizure medications (ASMs). It is an analogue of levetiracetam with limited real-life experience. The purpose of this study was to evaluate clinical experience with BRV with focus on efficacy, tolerability and pharmacokinetic variability among adult patients with difficult-to-treat epilepsy. METHODS: We retrospectively collected clinical and laboratory data from patients aged > 18 years who initiated treatment with BRV during 2016-2019 and were followed for > one year or cessation of BRV...
July 2022: Epilepsy Research
https://read.qxmd.com/read/35527473/lc-ms-ms-quantification-of-levetiracetam-lamotrigine-and-10-hydroxycarbazepine-in-tdm-of-epileptic-patients
#35
JOURNAL ARTICLE
Shan Zhou, Ruitong Li, Ziyi Chen, Ruina Ren, Xueding Wang, Qilin Dai, Dingshen Wen, Yanping Guan, Xiaoxu Zhang, Siyuan Tang, Liemin Zhou, Min Huang
BACKGROUND: To minimize drug-related toxicity and monitor dosing regimens, an ultra-sensitive, simple and high-throughput analytical method for therapeutic drug monitoring (TDM) is required. METHODS: A novel LC-MS/MS bioassay of levetiracetam (LEV), lamotrigi1/ne (LTG) and 10-hydroxycarbazepine (MHD) in human plasma was established. The analytes were separated on a Hypersil GOLDTM C18 column under a 2.5-min isocratic elution after one-step protein precipitation...
May 8, 2022: Biomedical Chromatography: BMC
https://read.qxmd.com/read/35523739/individualizing-doses-of-antiepileptic-drugs
#36
REVIEW
Giulia Liparoti, Beatrice Burchiani, Elisabetta Mencaroni, Domenico Tripodi, Giuseppe Di Cara, Alberto Verrotti
INTRODUCTION: This review aims to identify the optimal therapeutic dosage of anti-epileptic drugs in terms of efficacy and safety in patients with multiple comorbidities. AREAS COVERED: We have analyzed changes in terms of pharmacokinetics and pharmacodynamics of Brivaracetam, Carbamazepine, Lacosamide, Lamotrigine, Levetiracetam, Topiramate, Valproate, and Zonisamide in liver disease, chronic kidney disease, and in patients admitted to intensive care unit. Our literature search covers the past 5 years...
March 2022: Expert Opinion on Drug Metabolism & Toxicology
https://read.qxmd.com/read/35451230/clemizole-and-trazodone-are-effective-antiseizure-treatments-in-a-zebrafish-model-of-stxbp1-disorder
#37
JOURNAL ARTICLE
Maia Moog, Scott C Baraban
CRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants provide an efficient preclinical platform to test antiseizure therapeutics. The present study was designed to test antiseizure medications approved for clinical use and two recently identified repurposed drugs with antiseizure activity. Larval homozygous stxbp1b zebrafish (4 days postfertilization (dpf)) were agarose-embedded and monitored for electrographic seizure activity using a local field recording electrode placed in midbrain...
September 2022: Epilepsia Open
https://read.qxmd.com/read/35343204/antiepileptic-drug-tapering-and-seizure-recurrence-correlation-with-serum-drug-levels-and-biomarkers-in-persons-with-epilepsy
#38
JOURNAL ARTICLE
Sudhir C Sarangi, Sachin Kumar, Manjari Tripathi, Thomas Kaleekal, Surender Singh, Yogendra K Gupta
OBJECTIVES: Antiepileptic-drug (AED) serum level and inflammatory biomarkers are primarily monitored/assessed during epilepsy treatment for effective seizure control; however, their correlation with seizure recurrence (SR) following AED-tapering has not been established, and this is being investigated in this study. MATERIALS AND METHODS: This prospective observational study enrolled persons with epilepsy (PWE) on AED monotherapy and going to start tapering after being seizure-free for ≥2 years...
January 2022: Indian Journal of Pharmacology
https://read.qxmd.com/read/34785318/relevant-pharmacological-interactions-between-alkylating-agents-and-antiepileptic-drugs-preclinical-and-clinical-data
#39
REVIEW
Federico Cucchiara, Sara Ferraro, Giacomo Luci, Guido Bocci
Seizures are relatively common in cancer patients, and co-administration of chemotherapeutic and antiepileptic drugs (AEDs) is highly probable and necessary in many cases. Nonetheless, clinically relevant interactions between chemotherapeutic drugs and AEDs are rarely summarized and pharmacologically described. These interactions can cause insufficient tumor and seizure control or lead to unforeseen toxicity. This review focused on pharmacokinetic and pharmacodynamic interactions between alkylating agents and AEDs, helping readers to make a rational choice of treatment optimization, and thus improving patients' quality of life...
January 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/34753796/levetiracetam-pharmacokinetics-and-its-covariates-proposal-for-optimal-dosing-in-the-paediatric-population
#40
JOURNAL ARTICLE
Pavla Pokorná, Martin Šíma, Natálie Švestková, Ondřej Slanař
OBJECTIVES: Levetiracetam is an anticonvulsive drug increasingly used in paediatric populations. Ontogenesis may alter its pharmacokinetics, demanding dose individualisation of levetiracetam in paediatric populations. We therefore aimed to explore levetiracetam pharmacokinetics and to propose its optimal dosing in the paediatric population. METHODS: Individual levetiracetam pharmacokinetic parameters were calculated based on therapeutic drug monitoring data, using a one-compartmental model, and regression models were used to explore possible covariates...
November 9, 2021: European Journal of Hospital Pharmacy. Science and Practice
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