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Keywords Therapeutic drug monitoring le...

Therapeutic drug monitoring levetiracetam

https://read.qxmd.com/read/38467356/characterization-of-the-intrahippocampal-kainic-acid-model-in-female-mice-with-a-special-focus-on-seizure-suppression-by-antiseizure-medications
#1
JOURNAL ARTICLE
Melanie Widmann, Andreas Lieb, Barbara Fogli, Angela Steck, Anna Mutti, Christoph Schwarzer
Despite special challenges in the medical treatment of women with epilepsy, in particular preclinical animal studies were focused on males for decades and females have only recently moved into the focus of scientific interest. The intrahippocampal kainic acid (IHKA) mouse model of temporal lobe epilepsy (TLE) is one of the most studied models in males reproducing electroencephalographic (EEG) and histopathological features of human TLE. Hippocampal paroxysmal discharges (HPDs) were described as drug resistant focal seizures in males...
March 9, 2024: Experimental Neurology
https://read.qxmd.com/read/38432875/effects-of-plateau-hypoxia-on-pharmacokinetic-parameters-and-cerebral-blood-distribution-of-levetiracetam-in-rats
#2
JOURNAL ARTICLE
Anpeng Zhao, Lin Hu, Wanteng Yao, Xiwen Chang, Rong Wang, Wenbin Li
OBJECTIVES: Plateau hypoxia exposure causes changes in pharmacokinetic parameters and cerebral-blood distribution of drugs, including many substrates of P-glycoprotein (P-gp). Levetiracetam, a kind of antiepileptic drugs, is a substrate of P-gp. Whether plateau hypoxia exposure changes its pharmacokinetic characteristics and cerebral-blood distribution remains unclear. This study aims to investigate the effects of plateau hypoxia on the pharmacokinetics and cerebra-blood distribution of levetiracetam...
October 28, 2023: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/38400747/therapeutic-drug-monitoring-in-pregnancy-levetiracetam
#3
JOURNAL ARTICLE
Noam Fallik, Ilia Trakhtenbroit, Firas Fahoum, Lilach Goldstein
OBJECTIVE: Levetiracetam (LEV) is an antiseizure medication that is mainly excreted by the kidneys. Due to its low teratogenic risk, LEV is frequently prescribed for women with epilepsy (WWE). Physiological changes during gestation affect the pharmacokinetic characteristics of LEV. The goal of our study was to characterize the changes in LEV clearance during pregnancy and the postpartum period, to better plan an LEV dosing paradigm for pregnant women. METHODS: This retrospective observational study incorporated a cohort of women who were followed up at the epilepsy in pregnancy clinic at Tel Aviv Sourasky Medical Center during the years 2020-2023...
February 24, 2024: Epilepsia
https://read.qxmd.com/read/38067559/simple-hplc-uv-method-for-therapeutic-drug-monitoring-of-12-antiepileptic-drugs-and-their-main-metabolites-in-human-plasma
#4
JOURNAL ARTICLE
Daniela Milosheska, Robert Roškar
The objective of the present report was to develop and validate a simple, selective, and reproducible high-performance liquid chromatography method with UV detection suitable for routine therapeutic drug monitoring of the most commonly used antiepileptic drugs and some of their metabolites. Simple precipitation of plasma proteins with acetonitrile was used for sample preparation. 10,11-dihydrocarbamazepine was used as an internal standard. Chromatographic separation of the analytes was achieved by gradient elution on a Phenyl-Hexyl column at 40 °C, using methanol and potassium phosphate buffer (25 mM; pH 5...
November 28, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38036809/quantitative-lc-ms-ms-method-for-the-simultaneous-measurement-of-six-antiepileptics-and-pentobarbital-in-human-serum
#5
JOURNAL ARTICLE
Geza S Bodor, Amanda J Rands
Antiepileptic drugs (AEDs) are a chemically diverse group of medications that are used to control seizures and different clinical forms of epilepsy. AEDs can be used as single agents but are commonly administered in combination, as a multi-drug regimen. AEDs have narrow therapeutic windows. Therapeutic ranges may not be properly defined, and symptoms of toxic serum concentrations may include increased frequency of seizures, as seen when AED concentrations are subtherapeutic. Pentobarbital, a barbiturate, is a potent anti-seizure medication, but it is also used in the treatment of head injury...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38036808/turbulent-flow-liquid-chromatography-tandem-mass-spectrometry-methods-for-antiepileptic-drug-quantitation-in-serum
#6
JOURNAL ARTICLE
Adam S Ptolemy, Roy W A Peake, Mark D Kellogg
Epilepsy is characterized by abnormal electrical discharges in the brain that result in unprovoked seizures. Pharmacotherapy with antiepileptic drugs (AED) can help control the incidence of epileptic seizures. AED therapeutic regimens often need to be individually tailored. Therapeutic drug monitoring (TDM) of AED is required to optimize therapeutic efficacy and minimize the risk of any associated destructive toxicities. We describe a turbulent flow liquid chromatography-tandem mass spectrometry (TFC-MS/MS) method for the detection of seven different AED in human serum...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38036171/clinical-impact-of-therapeutic-drug-monitoring-for-newer-anti-seizure-medications-in-patients-with-epilepsy-a-real-world-observation-study
#7
JOURNAL ARTICLE
Siew-Na Lim, Tony Wu, Chun-Wei Chang, Wei-En Johnny Tseng, Mei-Yun Cheng, Hsiang-Yao Hsieh, Chih-Hong Lee, Wey-Ran Lin, Chun-Jing Liu, Po-Ru Chen, Chia-Ni Lin
BACKGROUND: The clinical value of therapeutic drug monitoring (TDM) for newer anti-seizure medications (ASMs) remains uncertain. This study aimed to assess the impact of newer ASM TDM on clinical decision making in patients with epilepsy. METHODS: We retrospectively identified all plasma requests for newer ASM level measurement as part of routine clinical management in the outpatient departments of seven medical institutes across Taiwan between September 2016 and May 2019...
November 28, 2023: Biomedical Journal
https://read.qxmd.com/read/37990827/quantitation-of-levetiracetam-concentrations-in-plasma-and-saliva-samples-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry-application-to-therapeutic-drug-monitoring-for-pregnant-women-with-epilepsy
#8
JOURNAL ARTICLE
Mengyu Zhang, Ying Jin, Wanling Li, Chaoqun He, Xiangjie Di, Yifei Duan, Lei Chen, Zhenlei Wang
Although levetiracetam (LEV) has favorable linear pharmacokinetic properties, therapeutic drug monitoring (TDM) is necessary for pregnant women with epilepsy. This study aims to build a simple, reliable, and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for determining LEV concentrations in plasma and saliva samples, to support the routine TDM of LEV in Chinese pregnant women with epilepsy. The stable isotope-labeled LEV-d6 was used as the internal standard. The extracted samples were analyzed using a UPLC-MS/MS system with positive electrospray ionization...
November 22, 2023: Biomedical Chromatography: BMC
https://read.qxmd.com/read/37936917/alzheimer-s-disease-and-epilepsy-shared-neuropathology-guides-current-and-future-treatment-strategies
#9
REVIEW
Olivia Lu, Taimur Kouser, Irina A Skylar-Scott
Epilepsy is a cause of profound disability in patients with Alzheimer's disease (AD). The risk of being diagnosed with AD increases the risk for epilepsy, and in parallel, a history of epilepsy increases the likelihood of the development of AD. This bi-directional relationship may be due to underlying shared pathophysiologic hallmarks, including decreased cerebrospinal fluid amyloid beta 42 (Aβ42), increased hyperphosphorylated tau protein, and hippocampal hyperexcitability. Additionally, there are practical treatment considerations in patients with co-morbid AD and epilepsy-namely, there is a higher risk of seizures associated with medications commonly prescribed for Alzheimer's disease patients, including antidepressants and antipsychotics such as trazodone, serotonin norepinephrine reuptake inhibitors (SNRIs), and first-generation neuroleptics...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37857032/real-world-practices-for-the-care-of-women-with-epilepsy-during-pregnancy-a-canadian-perspective
#10
JOURNAL ARTICLE
Tadeu A Fantaneanu, Hayley F Thornton, Tinghua Zhang, Eduard Bercovici, Chantelle Hrazdil, Kristin M Ikeda, Janani Kassiri, Ana Suller Marti, Raluca Pana, Arezoo Rezazadeh, Eliane Kobayashi, Esther Bui
OBJECTIVE: Approximately 150,000 Canadian women live with epilepsy, a population that presents with unique challenges. Our objective was to capture demographic and real-world practice characteristics of Canadian healthcare professionals providing care for women with epilepsy (WWE) with specific focus on reproductive considerations to identify potential gaps in knowledge and care. METHODS: A questionnaire developed by the Canadian League Against Epilepsy WWE workgroup was distributed to Canadian healthcare professionals from February 2021 to October 2022 to capture participant demographic characteristics and practice patterns in key areas of the reproductive cycle in WWE...
October 17, 2023: Epilepsy & Behavior: E&B
https://read.qxmd.com/read/37798082/short-subcutaneous-infusions-for-symptom-control-in-palliative-medicine
#11
JOURNAL ARTICLE
Paul Howard, Sandra Clawson, John Curtin
OBJECTIVES: To investigate the efficacy and safety of short subcutaneous infusions (SSCIs) for refractory symptoms in the palliative setting. METHODS: A retrospective chart review of SSCIs in a single palliative care centre over an 18-month period. All clinical notes, medication administration records and infusion monitoring documentation were examined to ascertain therapeutic aim, efficacy and tolerability. RESULTS: 111 patients received one or more SSCIs, 28 in the community and 83 in the inpatient hospice (21% of all admissions)...
October 5, 2023: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/37711412/a-retrospective-case-series-on-valproic-acid-for-early-post-traumatic-seizure-prophylaxis-after-traumatic-brain-injury-in-patients-with-concomitant-agitation
#12
JOURNAL ARTICLE
Diari Nicole Gilliam, Preeyaporn Sarangarm, Kirsten Elwood
Purpose: Early post-traumatic seizures occur within 7 days following a traumatic brain injury and may lead to additional brain damage and poor outcomes. Levetiracetam or phenytoin is often used for seizure prophylaxis in this patient population, but valproic acid may be an appropriate therapeutic alternative in patients with concomitant agitation. Evidence for the use of valproic acid for both early post-traumatic seizure prophylaxis and agitation is limited. The purpose of this study is to examine the safety and efficacy of valproic acid for both early post-traumatic seizure prophylaxis and agitation...
October 2023: Hospital Pharmacy
https://read.qxmd.com/read/37513857/a-5-year-study-of-antiseizure-medications-asms-monitoring-in-patients-with-neuropsychiatric-disorders-in-an-italian-clinical-center
#13
JOURNAL ARTICLE
Letizia Biso, Marco Carli, Shivakumar Kolachalam, Giorgio Monticelli, Pasquale Fabio Calabrò, Antonello di Paolo, Filippo Sean Giorgi, Guido Bocci, Marco Scarselli
Despite receiving appropriate antiseizure medications (ASMs), a relevant percentage of neuropsychiatric patients do not benefit from this approach, and one reason is subtherapeutic ASMs plasma concentration (C(p)) due to improper drug adherence, interindividual pharmacokinetic differences, or metabolic interactions among different drugs. For these reasons, therapeutic drug monitoring (TDM) by measuring ASMs C(p) is an effective tool that improves pharmacological therapies in clinical practice. Based on these premises, in the present real-world study, we analyzed the C(p) of the most used ASMs in diverse medical conditions, which were assayed during the years 2018-2022 at the University Hospital of Pisa, including about 24,000 samples...
June 29, 2023: Pharmaceuticals
https://read.qxmd.com/read/37475012/phenytoin-induced-dyskinesia-a-case-report
#14
JOURNAL ARTICLE
Kashvi C Shah, Nishi S Patel, Paritosh Vasani, Avinash Khadela, Vivek P Chavda, Lalitkumar Vora
BACKGROUND: Dyskinesia is a movement disorder categorized by involuntary movement of muscle. Although dyskinesia can be brought on by taking medications, it can also be a symptom of a variety of diseases. Antiepileptic drug-induced involuntary movements have been well researched. Rare reports have been made for dyskinesia, a type of dystonia caused by phenytoin. The mechanism of its occurrence must be succinctly studied. CASE PRESENTATION: A 53-year-old Asian patient taking phenytoin (100 mg twice daily) experienced symptoms of perioral muscle involuntary movement, impaired speech, and generalized tremors and was admitted to the hospital...
July 21, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/37192596/therapeutic-drug-monitoring-and-the-therapeutic-reference-range-of-levetiracetam-for-chinese-patients-problems-and-issues
#15
JOURNAL ARTICLE
Min Shi, Chenxi Liu, Lien He, Huizheng Wu, Yin Wu
BACKGROUND: Levetiracetam (LEV) is widely used in the clinical monotherapy or multi-drug combination treatment of seizures due to its good tolerability and efficacy. Due to a lack of large-scale clinical studies, the relationship between levetiracetam concentrations, disease activity and adverse is unclear, limiting the usefulness of therapeutic drug monitoring (TDM) based LEV plasma levels. This study was intended to investigate factors influencing the pharmacokinetics of and the appropriate reference range of LEV concentration using available LEV TDM data...
May 12, 2023: Seizure: the Journal of the British Epilepsy Association
https://read.qxmd.com/read/37057954/decreased-serum-concentrations-of-anti-seizure-medications-in-children-with-drug-resistant-epilepsy-following-treatment-with-ketogenic-diet
#16
JOURNAL ARTICLE
Sigrid Pedersen, Magnhild Kverneland, Knut Rudi, Kristina Gervin, Cecilie Johannessen Landmark, Per Ole Iversen, Kaja Kristine Selmer
OBJECTIVE: To examine the potential influence of a ketogenic diet on serum concentrations of anti-seizure medications (ASMs) in children with drug resistant epilepsy. METHODS: We investigated the serum concentrations of ASMs in 25 children with drug resistant epilepsy, 2 to 13 years of age, treated with a classical ketogenic diet for 12 weeks. The patients were recruited from the National Centre for Epilepsy from August 15th , 2017, to January 24th , 2022...
April 14, 2023: Epilepsia Open
https://read.qxmd.com/read/36991982/disposable-sensor-chips-with-molecularly-imprinted-carbon-paste-electrodes-for-monitoring-anti-epileptic-drugs
#17
JOURNAL ARTICLE
Aaryashree, Ashish Kumar Choudhary, Yasuo Yoshimi
Epilepsy is a neurological disorder that affects millions of people worldwide. Anti-epileptic drugs (AEDs) are critical for their management. However, the therapeutic window is narrow, and traditional laboratory-based therapeutic drug monitoring (TDM) methods can be time consuming and unsuitable for point-of-care testing. To address this issue, we developed a disposable sensor chip based on molecularly imprinted polymer-modified carbon paste electrodes (MIP-CPs) for the TDM of AEDs such as phenobarbital (PB), carbamazepine (CBZ), and levetiracetam (LEV)...
March 20, 2023: Sensors
https://read.qxmd.com/read/36974592/direct-thermal-growth-of-gold-nanopearls-on-3d-interweaved-hydrophobic-fibers-as-ultrasensitive-portable-sers-substrates-for-clinical-applications
#18
JOURNAL ARTICLE
Hsin-Yao Lin, Wan-Ru Chen, Li-Chia Lu, Hsuen-Li Chen, Yu-Hsuan Chen, Michael Pan, Chi-Chia Chen, Chihchen Chen, Tzung-Hai Yen, Dehui Wan
Surface-enhanced Raman spectroscopy (SERS)-based biosensors have attracted much attention for their label-free detection, ultrahigh sensitivity, and unique molecular fingerprinting. In this study, a wafer-scale, ultrasensitive, highly uniform, paper-based, portable SERS detection platform featuring abundant and dense gold nanopearls with narrow gap distances, are prepared and deposited directly onto ultralow-surface-energy fluorosilane-modified cellulose fibers through simple thermal evaporation by delicately manipulating the atom diffusion behavior...
March 28, 2023: Small
https://read.qxmd.com/read/36894298/analytical-and-clinical-validation-of-an-lc-ms-ms-method-for-carbamazepine-lamotrigine-and-levetiracetam-in-dried-blood-spots
#19
JOURNAL ARTICLE
Daphne den Besten-Bertholee, Ilse Wegner, Daan J Touw, Peter G J Ter Horst
OBJECTIVES: Therapeutic drug monitoring is performed routinely in patients on anti-epileptic drugs (AEDs) for optimisation and individualisation of therapy. The dried blood spot (DBS) sampling technique is a suitable, more patient-friendly alternative for conventional venous sampling methods. However, before DBS can be used in routine care, data are needed to establish the correlation between standard plasma concentrations obtained from venous puncture and concentrations measured through DBS obtained by finger prick...
March 9, 2023: European Journal of Hospital Pharmacy. Science and Practice
https://read.qxmd.com/read/36759254/clinical-value-of-therapeutic-drug-monitoring-for-levetiracetam-in-pediatric-patients-with-epilepsy
#20
JOURNAL ARTICLE
Yoshiaki Yamamoto, Akiko Ohta, Naotaka Usui, Katsumi Imai, Yoshiyuki Kagawa, Yukitoshi Takahashi
PURPOSE: To identify pediatric patients who require therapeutic drug monitoring (TDM) of levetiracetam (LEV). METHODS: We retrospectively investigated 2413 routine therapeutic drug monitoring data on serum LEV concentration from 1398 pediatric patients (age, 0-15 years). Samples were grouped by age (infants, < 1 year; preschool children, 1-5 years; primary school children, 6-11 years; and adolescents, 12-15 years), and the LEV concentration-to-dose (CD) ratio was calculated...
February 7, 2023: Brain & Development
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