Alicia N Harracksingh, Anhadvir Singh, Tatiana Mayorova, Brian Bejoy, Jillian Hornbeck, Wassim Elkhatib, Gregor McEdwards, Julia Gauberg, Abdul R W Taha, Ishrat M Islam, Ted Erclik, Mark A Currie, Marcus Noyes, Adriano Senatore
PDZ domain mediated interactions with voltage-gated calcium (Ca V ) channel C-termini play important roles in localizing and compartmentalizing membrane Ca 2+ signaling. The first such interaction discovered was between the neuronal multi-domain protein Mint-1, and the presynaptc calcium channel Ca V 2.2 in mammals. Although the physiological significance of this interaction is unclear, its occurrence in vertebrates and bilaterian invertebrates suggests important and conserved functions. In this study, we explore the evolutionary origins of Mint and its interaction with Ca V 2 channels...
February 29, 2024: bioRxiv