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Medication adherance statin

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https://www.readbyqxmd.com/read/28196429/medical-and-psychosocial-factors-and-unfavourable-low-density-lipoprotein-cholesterol-control-in-coronary-patients
#1
John Munkhaugen, Elise Sverre, Jan E Otterstad, Kari Peersen, Erik Gjertsen, Joep Perk, Lars Gullestad, Torbjørn Moum, Toril Dammen, Einar Husebye
Objective Understanding the determinants of low-density lipoprotein cholesterol (LDL-C) control constitutes the basis of modelling interventions for optimal lipid control and prognosis. We aim to identify medical and psychosocial (study) factors associated with unfavourable LDL-C control in coronary patients. Methods A cross-sectional explorative study used logistic and linear regression analysis to investigate the association between study factors and LDL-C in 1095 patients, hospitalized with myocardial infarction and/or a coronary revascularization procedure...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28195516/young-adulthood-cognitive-ability-predicts-statin-adherence-in-middle-aged-men-after-first-myocardial-infarction-a-swedish-national-registry-study
#2
John Wallert, Claudia Lissåker, Guy Madison, Claes Held, Erik Olsson
Background Cognitive ability (CA) is positively related to later health, health literacy, health behaviours and longevity. Accordingly, a lower CA is expected to be associated with poorer adherence to medication. We investigated the long-term role of CA in adherence to prescribed statins in male patients after a first myocardial infarction (MI). Methods CA was estimated at 18-20 years of age from Military Conscript Register data for first MI male patients (≤60 years) and was related to the one- and two-year post-MI statin adherence on average 30 years later...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28186924/can-purchasing-information-be-used-to-predict-adherence-to-cardiovascular-medications-an-analysis-of-linked-retail-pharmacy-and-insurance-claims-data
#3
Alexis A Krumme, Gabriel Sanfélix-Gimeno, Jessica M Franklin, Danielle L Isaman, Mufaddal Mahesri, Olga S Matlin, William H Shrank, Troyen A Brennan, Gregory Brill, Niteesh K Choudhry
OBJECTIVE: The use of retail purchasing data may improve adherence prediction over approaches using healthcare insurance claims alone. DESIGN: Retrospective. SETTING AND PARTICIPANTS: A cohort of patients who received prescription medication benefits through CVS Caremark, used a CVS Pharmacy ExtraCare Health Care (ECHC) loyalty card, and initiated a statin medication in 2011. OUTCOME: We evaluated associations between retail purchasing patterns and optimal adherence to statins in the 12 subsequent months...
November 9, 2016: BMJ Open
https://www.readbyqxmd.com/read/28186442/clinical-determinants-and-treatment-gaps-in-familial-hypercholesterolemia-data-from-a-multi-ethnic-regional-health-service
#4
Barak Zafrir, Ayman Jubran, Gil Lavie, David A Halon, Moshe Y Flugelman, Chen Shapira
Background Familial hypercholesterolemia is characterized by markedly increased low-density lipoprotein cholesterol and risk for premature atherosclerotic cardiovascular disease. Models of care vary and reflect differing health policies and resources. The availability of electronic databases may enable better identification and assessment of familial hypercholesterolemia in the community. Methods A regional healthcare database was utilized to identify patients with a high probability of familial hypercholesterolemia, clinically defined by age-dependent-peak low-density lipoprotein cholesterol cutoffs and exclusion of secondary causes of severe hypercholesterolemia...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28119384/assessing-potential-population-impact-of-statin-treatment-for-primary-prevention-of-atherosclerotic-cardiovascular-diseases-in-the-usa-population-based-modelling-study
#5
Quanhe Yang, Yuna Zhong, Cathleen Gillespie, Robert Merritt, Barbara Bowman, Mary G George, W Dana Flanders
OBJECTIVE: New cholesterol treatment guidelines from American College of Cardiology/American Heart Association recommend statin treatment for more of US population to prevent atherosclerotic cardiovascular disease (ASCVD). It is important to assess how new guidelines may affect population-level health. This study assessed the impact of statin use for primary prevention of ASCVD under the new guidelines. METHODS: We used data from 2010 US Multiple Cause Mortality, Third National Health and Nutrition Examination Survey (NHANES III) Linked Mortality File (1988-2006, n=8941) and NHANES 2005-2010 (n=3178) participants 40-75 years of age for the present study...
January 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/27987574/-new-choosing-wisely-recommendations-of-inappropriate-interventions-the-perspective-of-general-practioners-in-switzerland
#6
Stefan Neuner-Jehle, Oliver Senn, Thomas Rosemann
AIM: As part of the "Choosing wisely" campaign expert-driven recommendations of inappropriate interventions which lead to overdiagnosis and overtreatment are being published. The aim of our work was to describe an innovative method for developing recommendations together with general practitioners (GPs) and to compare the results with the "Choosing wisely" campaign lists as well as with the Swiss "Smarter medicine" shortlist. METHODS: We asked 109 GPs who attended a medical education conference to form groups (of 5 to 7 GPs each) and develop three interventions that are relevant to their work and should be avoided...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27957818/optimal-pharmacological-treatment-and-adherence-to-medication-in-secondary-prevention-of-cardiovascular-events-in-spain-results-from-the-caps-study
#7
Alberto Cordero, Luis Rodriguez Padial, Alberto Batalla, Luis López Barreiro, Francisco Torres Calvo, Jose M Castellano, Emilio Ruiz, Vicente Bertomeu-Martínez
INTRODUCTION: Despite the large amount of evidence supporting the use of antiplatelet agents, beta-blockers, angiotensin antagonists, and lipid-lowering statins in patients with stable coronary artery disease, several studies have documented underprescription of optimal medical treatment (OMT) in Spain. AIMS: The present study aims to describe the current trend of pharmacological prescription in secondary prevention treatment for cardiovascular diseases (CVD) in a Spanish cohort...
December 13, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27931556/non-physician-health-workers-for-improving-adherence-to-medications-and-healthy-lifestyle-following-acute-coronary-syndrome-24-month-follow-up-study
#8
Krishna Kumar Sharma, Rajeev Gupta, Mukul Mathur, Vishnu Natani, Sailesh Lodha, Sanjeeb Roy, Denis Xavier
OBJECTIVE: To evaluate usefulness of non-physician health workers (NPHW) to improve adherence to medications and lifestyles following acute coronary syndrome (ACS). METHODS: We randomized 100 patients at hospital discharge following ACS to NPHW intervention (n=50) or standard care (n=50) in an open label study. NPHW was trained for interventions to improve adherence to medicines - antiplatelets, β-blockers, renin-angiotensin system (RAS) blockers and statins and healthy lifestyles...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27903216/treatment-and-response-to-statins-gender-related-differences
#9
Raparelli Valeria, Pannitteri Gaetano, Todisco Tommaso, Toriello Filippo, Napoleone Laura, Manfredini Roberto, Basili Stefania
Response to drug administration is a primary determinant for treatment success. Sex and gender disparities play a role in determining the efficacy and safety of the most common used medications suggesting the need for a sex-tailored approach in prescription. Statins are a cost-effective strategy for cardiovascular disease (CVD) prevention. While statins are similarly effective in secondary CVD prevention, some concerns raised by conflicting data reported in primary CVD prevention clinical trials. The small representation of women in clinical trials and the fewer rates of events due to the lower female baseline CVD risk may have conditioned contradictory meta-analysis findings...
November 17, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27881912/assessing-the-feasibility-and-quality-of-shared-decision-making-in-china-evaluating-a-clinical-encounter-intervention-for-chinese-patients
#10
Rongchong Huang, Xiantao Song, Jian Wu, Wei Huang, Aaron L Leppin, Michael R Gionfriddo, Yongxian Liu, Kasey R Boehmer, Henry H Ting, Victor M Montori
BACKGROUND: The aim of this study was to evaluate the feasibility of using the Statin Choice decision aid to have discussions about starting a statin medication for cardiovascular risk reduction in Chinese patients with stable coronary artery diseases. METHODS: A prospective, pilot study of the Statin Choice decision aid in two teaching hospitals in Northern China was conducted. A total of seven clinicians were enrolled and underwent a 12-hour, group-based, in-person training on shared decision making (SDM) and the Statin Choice decision aid...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27864383/use-of-pharmacogenetic-information-in-the-treatment-of-cardiovascular-disease
#11
REVIEW
Kevin Friede, Josephine Li, Deepak Voora
BACKGROUND: In 1964, Robert A. O'Reilly's research group identified members of a family who required remarkably high warfarin doses (up to 145 mg/day, 20 times the average dose) to achieve appropriate anticoagulation. Since this time, pharmacogenetics has become a mainstay of cardiovascular science, and genetic variants have been implicated in several fundamental classes of medications used in cardiovascular medicine. CONTENT: In this review, we discuss genetic variants that affect drug response to 3 classes of cardiovascular drugs: statins, platelet P2Y12 inhibitors, and anticoagulants...
January 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27864247/impact-of-a-pharmacist-delivered-discharge-and-follow-up-intervention-for-patients-with-acute-coronary-syndromes-in-qatar-a-study-protocol-for-a-randomised-controlled-trial
#12
Amani Zidan, Ahmed Awaisu, Nadir Kheir, Ziyad Mahfoud, Rasha Kaddoura, Sumaya AlYafei, Maguy Saffouh El Hajj
INTRODUCTION: Acute coronary syndrome (ACS) is one of the leading causes of morbidity and mortality worldwide. Secondary cardiovascular risk reduction therapy (consisting of an aspirin, a β-blocker, an ACE inhibitor or an angiotensin II receptor blocker and a statin) is needed for all patients with ACS. Less than 80% of patients with ACS in Qatar use this combination after discharge. This study is aimed to evaluate the effectiveness of clinical pharmacist-delivered intervention at discharge and tailored follow-up postdischarge on decreasing hospital readmissions, emergency department (ED) visits and mortality among patients with ACS...
November 18, 2016: BMJ Open
https://www.readbyqxmd.com/read/27855628/treatment-and-response-to-statins-gender-related-differences
#13
Raparelli Valeria, Pannitteri Gaetano, Todisco Tommaso, Toriello Filippo, Napoleone Laura, Manfredini Roberto, Basili Stefania
Response to drug administration is a primary determinant for treatment success. Sex and gender disparities play a role in determining the efficacy and safety of the most common used medications suggesting the need for a sex-tailored approach in prescription. Statins are a cost-effective strategy for cardiovascular disease (CVD) prevention. While statins are similarly effective in secondary CVD prevention, some concerns raised by conflicting data reported in primary CVD prevention clinical trials. The small representation of women in clinical trials and the fewer rates of events due to the lower female baseline CVD risk may have conditioned contradictory meta-analysis findings...
November 17, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27829968/does-hospitalist-directed-care-for-acute-ischemic-stroke-patients-improve-adherence-to-get-with-the-guidelines
#14
Ameer E Hassan, Stephanie E Ossowski, Ahmed A Malik, Christina Sanchez, Erlinda Abantao, Olive Sanchez, Wondwossen G Tekle, Adnan I Qureshi
BACKGROUND AND PURPOSE: Hospitalist directed care is associated with improved outcomes in several medical conditions. The hospitalist effect has not been studied in acute ischemic stroke (AIS) patients. We compare length of stay (LOS), outcome, and adherence to "Get with the Guidelines" (GWTG) stroke quality measures among AIS patients admitted under a hospitalist with three other specialties (internist, family practice, or specialist). METHODS: We collected demographics, risk factors and discharge outcomes (modified Rankin Scale (mRS)) for consecutive AIS patients over 4-year period (2010-2014)...
October 2016: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/27826756/characteristics-associated-with-nonadherence-to-medications-for-hypertension-diabetes-and-dyslipidemia-among-breast-cancer-survivors
#15
Gregory S Calip, Joann G Elmore, Denise M Boudreau
OBJECTIVE: Comorbidity among breast cancer survivors is prevalent, and adherence to medication management of comorbidities may be important for both chronic disease and cancer-related outcomes. Our objective was to determine characteristics associated with nonadherence to common chronic medications among breast cancer survivors. METHODS: We conducted a retrospective cohort study of 4216 women in an integrated care system diagnosed with early-stage breast cancer between 1990 and 2008 and alive without recurrence or second primary breast cancer in the second-year following diagnosis...
November 8, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27825313/using-pharmacists-to-improve-risk-stratification-and-management-of-stage-3a-chronic-kidney-disease-a-feasibility-study
#16
Alex R Chang, Michael Evans, Christina Yule, Larissa Bohn, Amanda Young, Meredith Lewis, Elisabeth Graboski, Bethany Gerdy, William Ehmann, Jonathan Brady, Leah Lawrence, Natacha Antunes, Jamie Green, Susan Snyder, H Lester Kirchner, Morgan Grams, Robert Perkins
BACKGROUND: Measurement of albuminuria to stratify risk in chronic kidney disease (CKD) is not done universally in the primary care setting despite recommendation in KDIGO (Kidney Disease Improving Global Outcomes) guidelines. Pharmacist medication therapy management (MTM) may be helpful in improving CKD risk stratification and management. METHODS: We conducted a pragmatic, cluster-randomized trial using seven primary care clinic sites in the Geisinger Health System to evaluate the feasibility of pharmacist MTM in patients with estimated glomerular filtration rate (eGFR) 45-59 ml/min/1...
November 8, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27819152/blood-pressure-and-lipid-target-adherence-in-korean-patients-receiving-angiotensin-ii-receptor-blockers-statin-regimens
#17
Hyun-Jin Kim, Eugene Kim, Kyoung-Bok Min, Jin-Young Min
OBJECTIVES: Hypertension and dyslipidemia are important cardiovascular risk factors. Simultaneously controlling blood pressure (BP) and lipid levels is effective in preventing cardiovascular events and premature death. This study investigated the association between adherence to angiotensin II receptor blocker (ARB)/statin regimens and BP or low density lipoprotein-cholesterol (LDL-C) target attainment in Korean patients with concomitant hypertension and dyslipidemia. METHODS: In this retrospective, multicenter study, we collected case report forms (CRFs) of hypertensive patients with concomitant dyslipidemia who were prescribed an ARB/statin regimen between 1 April 2014 and 31 March 2015 from 51 outpatient clinics...
February 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27798247/rechallenging-statin-therapy-in-veterans-with-statin-induced-myopathy-post-vitamin-d-replenishment
#18
Jenny H Kang, Quynh-Nhu Nguyen, Juleann Mutka, Quang A Le
BACKGROUND: Statins are the primary class of medications used to lower cholesterol and reduce risks for coronary heart disease. However, statin muscular adverse effects are one of the main reasons for statin nonadherence and a barrier to cardiovascular risk reduction. OBJECTIVES: The primary objective of our study was to examine the effect of replenishing vitamin D on statin-induced myopathy in veteran patients who failed to maintain statin therapy in a pharmacist-run ambulatory care setting...
October 24, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27783554/is-the-currently-used-prescription-adjudication-date-a-good-proxy-for-calculating-medication-refill-adherence
#19
Corey A Lester, Kevin A Look, Michelle A Chui
BACKGROUND: The Centers for Medicare & Medicaid Services (CMS) adopted the proportion of days covered (PDC) calculation for use in their Five-Star Quality Rating System for Medicare Advantage and Prescription Drug Plans. This calculation uses the prescription adjudication date (i.e., date the prescription is billed to the benefits manager by a pharmacy) as a proxy for medication adherence. Adherence programs, such as automatic refill programs, have become commonplace in community pharmacy and have been identified by industry leaders as interfering with the ability to accurately measure adherence using PDC...
November 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27779436/observational-prospective-study-to-estimate-the-rates-of-outcomes-in-patients-undergoing-pci-with-drug-eluting-stent-implantation-who-take-statins-follow-up-optima-ii
#20
Yu Karpov, N Logunova, D Tomilova, V Buza, Yu Khomitskaya
OBJECTIVE: The OPTIMA II study sought to evaluate rates of major adverse cardiac and cerebrovascular events (MACCEs) during the long-term follow-up of chronic statin users who underwent percutaneous coronary intervention (PCI) with implantation of a drug-eluting stent (DES). RESEARCH DESIGN AND METHODS: OPTIMA II was a non-interventional, observational study conducted at a single center in the Russian Federation. Included patients were aged ≥18 years with stable angina who had received long-term (≥1 month) statin therapy prior to elective PCI with DES implantation and who had participated in the original OPTIMA study...
February 2017: Current Medical Research and Opinion
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