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Medication adherance statin

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https://www.readbyqxmd.com/read/28439911/the-impact-of-an-appointment-based-medication-synchronization-programme-on-chronic-medication-adherence-in-an-adult-community-pharmacy-population
#1
S B Andrews, T R Marcy, B Osborn, L G Planas
WHAT IS KNOWN AND OBJECTIVES: Non-adherence to medication regimens is the primary cause of suboptimal clinical benefit in patients with chronic diseases. The primary objective of this study was to assess and compare adherence to chronic medications among adults participating in Time My Meds (TMM), an appointment-based medication synchronization programme, to patients receiving usual care. METHODS: This was a quasi-experimental study that evaluated data from 18 partner community pharmacies in three lower U...
April 24, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#2
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28436727/impact-of-switching-from-different-treatment-regimens-to-a-fixed-dose-combination-pill-polypill-in-patients-with-cardiovascular-disease-or-similarly-high-risk
#3
Melvin Lafeber, Wilko Spiering, Frank Lj Visseren, Diederick E Grobbee, Michiel L Bots, Alice Stanton, Anushka Patel, Dorairaj Prabhakaran, Ruth Webster, Simon Thom, Anthony Rodgers
Aims Cardiovascular fixed-dose combination pills, or polypills, may help address the widespread lack of access and adherence to proven medicines. Initiation of polypill-based care typically entails switching from current separately taken medications. Given the heterogeneity in usual care, there is interest in the impact of polypill treatment across different patterns of prior medication regimen. Methods A total of 2004 participants with established cardiovascular disease or estimated 5-year cardiovascular risk of over 15% were randomised to polypill-based treatment (aspirin 75 mg, simvastatin 40 mg, lisinopril 10 mg and either atenolol 50 mg or hydrochlorothiazide 12...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28436725/the-impact-of-medication-adherence-on-clinical-outcomes-of-coronary-artery-disease-a-meta-analysis
#4
Liping Du, Zhongwei Cheng, Yuxuan Zhang, Ying Li, Dan Mei
Background Long-term use of evidence-based medications is recommended by international guidelines for the management of stable coronary artery disease, however, non-adherence to medications is common. This meta-analysis aims to systematically evaluate the impact of medication adherence on clinical outcomes in patients with stable coronary artery disease. Methods Articles from January 1960-December 2015 were retrieved from the MEDLINE and EMBASE databases without any language restriction. A meta-analysis was performed to investigate the risk ratios of all-cause mortality, cardiovascular mortality, and myocardial infarction/hospitalization between groups with good medication adherence and poor medication adherence...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28427340/does-the-association-between-adherence-to-statin-medications-and-mortality-depend-on-measurement-approach-a-retrospective-cohort-study
#5
Mhd Wasem Alsabbagh, Dean Eurich, Lisa M Lix, Thomas W Wilson, David F Blackburn
BACKGROUND: The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures). METHODS: A retrospective cohort study was conducted using administrative data from Saskatchewan, Canada between 1994 and 2008. Eligible individuals received a prescription for a statin following hospitalization for acute coronary syndrome (ACS). Adherence was measured using proportion of days covered (PDC) expressed either as: 1) a fixed summary measure, or 2) as a repeatedly measured covariate...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28423147/adherence-to-high-intensity-statins-following-a-myocardial-infarction-hospitalization-among-medicare-beneficiaries
#6
Lisandro D Colantonio, Lei Huang, Keri L Monda, Vera Bittner, Maria-Corina Serban, Benjamin Taylor, Todd M Brown, Stephen P Glasser, Paul Muntner, Robert S Rosenson
Importance: High-intensity statins are recommended following myocardial infarction. However, patients may not continue taking this medication with high adherence. Objective: To estimate the proportion of patients filling high-intensity statin prescriptions following myocardial infarction who continue taking this medication with high adherence and to analyze factors associated with continuing a high-intensity statin with high adherence after myocardial infarction...
April 19, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28422521/different-approaches-to-the-assessment-of-adherence-and-persistence-with-cardiovascular-disease-preventive-medications
#7
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, María Jesús Lallana, María José Rabanaque, Javier Armesto, Enrica Menditto
OBJECTIVE: To assess suitability and comparability of the most common methods of treatment adherence and persistence assessment, as applied to the same pharmacy dataset. METHODS: Data on drugs prescribed for cardiovascular primary prevention to participants in the Aragon Workers' Health Study (AWHS) were collected from a regional electronic drug prescription database. Several different approaches were used to measure treatment adherence (with the Medication Possession Ratio [MPR]) and Proportion of Days Covered [PDC]) and persistence in new users by therapeutic subgroup...
April 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28418481/comparison-of-recommended-eligibility-for-primary-prevention-statin-therapy-based-on-the-us-preventive-services-task-force-recommendations-vs-the-acc-aha-guidelines
#8
Neha J Pagidipati, Ann Marie Navar, Hillary Mulder, Allan D Sniderman, Eric D Peterson, Michael J Pencina
Importance: There are important differences among guideline recommendations for using statin therapy in primary prevention. New recommendations from the US Preventive Services Task Force (USPSTF) emphasize therapy based on the presence of 1 or more cardiovascular disease (CVD) risk factors and a 10-year global CVD risk of 10% or greater. Objective: To determine the difference in eligibility for primary prevention statin treatment among US adults, assuming full application of USPSTF recommendations compared with the American College of Cardiology/American Heart Association (ACC/AHA) guidelines...
April 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28416321/targeted-deprescribing-in-an-outpatient-hemodialysis-unit-a%C3%A2-quality-improvement-study-to-decrease-polypharmacy
#9
Caitlin McIntyre, Rory McQuillan, Chaim Bell, Marisa Battistella
BACKGROUND: Polypharmacy in hemodialysis patients can result in adverse patient outcomes. Deprescribing tools can reduce polypharmacy, yet no method exists for an outpatient hemodialysis population. DESIGN: Quality improvement study. SETTING & PARTICIPANTS: 240 patients in a tertiary-care outpatient hemodialysis unit. QUALITY IMPROVEMENT PLAN: We aimed to: (1) develop a deprescribing tool for target medications with poor evidence for efficacy and safety, (2) determine its effectiveness in decreasing polypharmacy, and (3) monitor patient safety and satisfaction...
April 14, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28398553/how-do-stroke-survivors-and-their-carers-use-practitioners-advice-on-secondary-prevention-medications-qualitative-study-of-an-online-forum
#10
Nkeonye J Izuka, Matthew A W Alexander, Chantal Balasooriya-Smeekens, Jonathan Mant, Anna De Simoni
Background.: Secondary prevention medications reduce risk of stroke recurrence, yet many people do not receive recommended treatment, nor take medications optimally. Objective: . Exploring how patients report making use of practitioners' advice on secondary prevention medicines on an online forum and what feedback was received from other participants. Methods.: Thematic analysis of the archive of Talkstroke (2004-2011), UK. Posts including any secondary prevention medication terms, General Practitioner (GP) and their replies were identified...
April 10, 2017: Family Practice
https://www.readbyqxmd.com/read/28395917/-compliance-with-recommendations-in-secondary-prevention-of-stroke-in-primary-care
#11
Carmen Tamayo-Ojeda, Neus Parellada-Esquius, Betlem Salvador-González, Pilar Ángeles Oriol-Torón, M Dolores Rodríguez-Garrido, Dolores Muñoz-Segura
OBJECTIVE: Knowing compliance with secondary prevention recommendations of stroke in primary care and to identify factors associated with compliance. DESIGN: Multi-centre cross-sectional. SETTING: Health primary care centres in a metropolitan area (944,280 inhabitants). PARTICIPANTS: Patients aged 18years and over with ischemic brain disease diagnosis prior to 6months before the study. MAIN MEASUREMENTS: Clinical history records of demographic variables, risk factors and cardiovascular comorbidity, drugs, blood pressure values (BP), LDL-cholesterol and medical visits by doctor and nurses after the event...
April 7, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28372491/community-pharmacy-based-inducement-programs-are-associated-with-better-medication-adherence-a-cohort-study
#12
Scot H Simpson, Mu Lin, Dean T Eurich
BACKGROUND: Inducement programs can promote customer loyalty; however, the clinical effects of these programs are unknown. OBJECTIVE: To examine relationships among inducement program use, medication adherence, and health outcomes. METHODS: Alberta residents with ≥ 1 physician visit for diabetes or hypertension between April 2008 and March 2014 were eligible for this study and included if they were new statin users and alive at least 455 days after the first statin dispensation...
April 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28370742/evaluation-of-drug-related-problems-in-older-polypharmacy-primary-care-patients
#13
Sandra Vezmar Kovačević, Branislava Miljković, Milica Ćulafić, Milena Kovačević, Bojana Golubović, Marija Jovanović, Katarina Vučićević, Johan J de Gier
AIMS AND OBJECTIVES: Targeting older patients with predictive factors for drug-related problems (DRPs) could make clinical medication reviews more cost-effective. The aim of this study was to identify the number, type, and potential predictive factors for DRPs in older polypharmacy patients. METHODS: Community pharmacists performed clinical medication reviews and documented DRPs, types of interventions, and their implementation in older patients. RESULTS: Three hundred eighty-eight medication reviews were analyzed, 964 DRPs (average 2...
March 29, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28370404/impact-of-hospitalization-on-medication-adherence-estimation-in-claims-data
#14
Y-H Dong, N K Choudhry, A Krumme, M P Lee, L-C Wu, M-S Lai, J J Gagne
WHAT IS KNOWN AND OBJECTIVE: Pharmacy claims are commonly used to assess medication adherence. It is unclear how different approaches to handling hospitalizations compare to the gold standard of using outpatient and inpatient drug data. This study aimed to compare the impact of different approaches to handling hospitalizations on medication adherence estimation in administrative claims data. METHODS: We identified β-blocker initiators after myocardial infarction (MI) and statin initiators regardless of hospitalization histories in the population-based, Taiwan database, which includes outpatient and inpatient drug claims data...
March 29, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28359719/regional-variation-in-patient-selection-and-treatment-for-carotid-artery-disease-in-the-vascular-quality-initiative
#15
Katie E Shean, John C McCallum, Peter A Soden, Sarah E Deery, Joseph R Schneider, Brian W Nolan, Caron B Rockman, Marc L Schermerhorn
OBJECTIVE: Previous studies involving large administrative data sets have revealed regional variation in the demographics of patients selected for carotid endarterectomy (CEA) and carotid artery stenting (CAS) but lacked clinical granularity. This study aimed to evaluate regional variation in patient selection and operative technique for carotid artery revascularization using a detailed clinical registry. METHODS: All patients who underwent CEA or CAS from 2009 to 2015 were identified in the Vascular Quality Initiative (VQI)...
March 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28358217/influence-of-route-of-administration-drug-formulation-and-other-factors-on-adherence-to-treatment-in-rheumatoid-arthritis-pain-related-and-dyslipidaemia-non-pain-related
#16
Bruno Fautrel, Alejandro Balsa, Piet Van Riel, Marta Casillas, Jean-Philippe Capron, Carine Cueille, Inmaculada de la Torre
OBJECTIVES: A comprehensive review was performed to investigate the effect of route of administration on medication adherence and persistence in rheumatoid arthritis (RA) and to compare adherence/persistence with oral medications between RA and a non-painful disease (dyslipidaemia). RESEARCH DESIGN AND METHODS: Comprehensive database searches were performed to identify studies investigating medication adherence and/or persistence in adults with RA receiving conventional synthetic or biologic agents...
March 30, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28345442/predicting-1-year-statin-adherence-among-prevalent-users-a-retrospective-cohort-study
#17
Alexis A Krumme, Jessica M Franklin, Danielle L Isaman, Olga S Matlin, Angela Y Tong, Claire M Spettell, Troyen A Brennan, William H Shrank, Niteesh K Choudhry
BACKGROUND: Attempts to predict who is at risk of future nonadherence have largely focused on predictions at the time of therapy initiation; however, these users are only a small proportion of all patients on therapy at any point in time. Methods to predict nonadherence for established medication users, which have not been previously described in the literature, would be helpful to guide efforts to enhance the use of evidence-based therapies. OBJECTIVE: To test approaches for adherence prediction among prevalent statin users, namely the use of short-term filling behavior, investigator-specified predictors from medical and pharmacy administrative claims, and the empirical selection of potential predictors using the high-dimensional propensity score variable selection algorithm...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28341983/-management-of-different-cardiovascular-risk-factors-with-a%C3%A2-combination-tablet-polypill
#18
REVIEW
P Bramlage, W März, D Westermann, B Weisser, J H Wirtz, U Zeymer, P Baumgart, G van Mark, U Laufs, B K Krämer, T Unger
BACKGROUND: The multifactorial origin of cardiovascular diseases has led to polypharmacy in primary and secondary prophylaxis with evidence-based medications, such as statins, antihypertensive drugs and platelet aggregation inhibitors. The number of prescribed drugs correlates inversely to adherence and can lead to treatment failure. Fixed-dose combination drugs (polypills) could increase the medication adherence of patients, reduce risks and prevent cardiovascular events. METHODS: This review is based on publications that were retrieved from Medline (via PubMed) and The Cochrane Library...
March 24, 2017: Herz
https://www.readbyqxmd.com/read/28338879/evidence-for-detection-bias-by-medication-use-in-a-cohort-study-of-breast-cancer-survivors
#19
Heidi S Wirtz, Gregory S Calip, Diana S M Buist, Julie R Gralow, William E Barlow, Shelly Gray, Denise M Boudreau
In previous studies, we found modestly decreased and increased risks of second breast cancer events with the use of statins and antibiotics, respectively, after adjustment for surveillance mammography. We evaluated detection bias by comparing receipt of surveillance mammography among users of these 2 disparate classes of medication. Adult women diagnosed with early-stage breast cancer during 1990-2008 (n = 3,965) while enrolled in an integrated health-care plan (Group Health Cooperative; Washington State) were followed for up to 10 years in the Commonly Used Medications and Breast Cancer Outcomes (COMBO) Study...
April 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28326830/do-statin-users-adhere-to-a-healthy-diet-and-lifestyle-the-australian-diabetes-obesity-and-lifestyle-study
#20
Simran Johal, Kris M Jamsen, J Simon Bell, Kevin P Mc Namara, Dianna J Magliano, Danny Liew, Taliesin E Ryan-Atwood, Claire Anderson, Jenni Ilomäki
Background Lifestyle and dietary advice typically precedes or accompanies the prescription of statin medications. However, evidence for adherence to this advice is sparse. The objective was to compare saturated fat intake, exercise, alcohol consumption and smoking between statin users and non-users in Australia. Methods Data were analysed for 4614 participants aged ≥37 years in the Australian Diabetes, Obesity and Lifestyle study in 2011-2012. Statin use, smoking status and physical activity were self-reported...
April 2017: European Journal of Preventive Cardiology
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