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Jennifer Ernst, Christine D Aliory, Catherine R Yows
: The competing demands of caring for high-acuity patients, reducing health care costs, and improving access to specialty care are complex challenges facing all health care providers. One approach-empowering nurses to expand their scope of practice-has been successfully employed for two decades by the nurse and physician leadership of a neurology department in an urban academic medical center. This article discusses the department's implementation of a quality improvement initiative to enhance access to neurology services in an ambulatory clinic by extending nursing practice to include lumbar puncture...
March 2018: American Journal of Nursing
Fen Ran, Yage Wu, Minghuan Jiang, Yongtao Tan, Ying Liu, Lingbin Kong, Long Kang, Shaowei Chen
In this study, a hybrid electrode material for supercapacitors based on hierarchical porous carbon fiber@vanadium nitride nanoparticles is fabricated using the method of phase-separation mediated by the PAA-b-PAN-b-PAA tri-block copolymer. In the phase-separation procedure, the ionic block copolymer self-assembled on the surface of carbon nanofibers, and is used to adsorb NH4 VO3 . Thermal treatment at controlled temperatures under an NH3  : N2 atmosphere led to the formation of vanadium nitride nanoparticles that are distributed uniformly on the nanofiber surface...
February 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Montserrat Carles, Thomas Bach, Irene Torres-Espallardo, Dimos Baltas, Ursula Nestle, Luis Martí-Bonmatí
In lung cancer, quantification by Positron-Emission-Tomography/Computed-Tomography (PET/CT) imaging presents challenges due to respiratory movement. Our primary aim was to study the impact of the compensation of motion implied by retrospectively gated (4D)-PET/CT on the variability of PET quantitative parameters. Its significance was evaluated by comparison with respect to the variability due to (i) the voxel size comprised by image reconstruction and (ii) the voxel size in image post-resampling. The method employed for features extraction was chosen based on the analysis of: (i) the effect of the standardized-uptake-value (SUV) discretization on the complementarity between texture features (TF) and the conventional indexes; (ii) the impact of the segmentation method on image features variability and (iii) the variability of image features across the time frames of 4D-PET...
February 22, 2018: Physics in Medicine and Biology
H M C Shantha Kumara, Elli Sutton, Geoffrey A Bellini, Xiaohong Yan, Vesna Cekic Rn, Nipa Dilip Gandhi, Richard L Whelan
Minimally invasive colorectal resection (MICR) for colorectal cancer (CRC) is associated with elevated levels of seven proangiogenic proteins that persist for 2-4 weeks after surgery. The proangiogenic plasma may promote tumor growth postoperatively in patients with residual cancer. To the best of our knowledge, the impact of surgery on interleukin 8 (IL-8) levels is unknown. The aim of the present study was to evaluate plasma IL-8 levels after MICR for CRC. Patients with CRC enrolled in an institutional review board-approved plasma/data bank who underwent MICR were eligible...
March 2018: Molecular and Clinical Oncology
Jaime Cuevas, Ana Isabel Ruiz, Raúl Fernández
Clay and cement are known nano-colloids originating from natural processes or traditional materials technology. Currently, they are used together as part of the engineered barrier system (EBS) to isolate high-level nuclear waste (HLW) metallic containers in deep geological repositories (DGR). The EBS should prevent radionuclide (RN) migration into the biosphere until the canisters fail, which is not expected for approximately 103 years. The interactions of cementitious materials with bentonite swelling clay have been the scope of our research team at the Autonomous University of Madrid (UAM) with participation in several European Union (EU) projects from 1998 up to now...
February 21, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
Maysa Sarhan, Walter G Land, Wulf Tonnus, Christian P Hugo, Andreas Linkermann
When cells undergo necrotic cell death in either physiological or pathophysiological settings in vivo, they release highly immunogenic intracellular molecules and organelles into the interstitium and thereby represent the strongest known trigger of the immune system. With our increasing understanding of necrosis as a regulated and genetically determined process (RN, regulated necrosis), necrosis and necroinflammation can be pharmacologically prevented. This review discusses our current knowledge about signaling pathways of necrotic cell death as the origin of necroinflammation...
April 1, 2018: Physiological Reviews
Irene Zolotorofe, Robert Fortini, Pam Hash, Angel Daniels, Liana Orsolini, Andrea Mazzoccoli, Tina Gerardi
Evidence supports the return on investment for an RN in ambulatory care. Utilizing RNs to their fullest potential in ambulatory practices is essential to effectively manage population health. Bon Secours Health System launched a new role, patient navigator RNs, to ensure seamless transitions of complex patients across care settings, resulting in better patient outcomes and a financial return.
March 2018: Journal of Nursing Administration
K Mitev, Ch Dutsov, S Georgiev, T Boshkova, D Pressyanov
This work presents a method for measuring the depth distribution of222 Rn activity in soil gas. The method is based on the capacity of polycarbonates to absorb222 Rn and on the possibility of performing sensitive measurements of222 Rn absorbed by the polycarbonates via liquid scintillation counting (LSC). The method is the following: cylindrical holes are drilled along a metal rod and Makrofol® N polycarbonate foils enclosed in polyethylene envelopes are placed in each hole. The rod is driven into the soil and kept for a certain time...
February 15, 2018: Journal of Environmental Radioactivity
Jan Gerit Brandenburg, Christoph Bannwarth, Andreas Hansen, Stefan Grimme
A revised version of the well-established B97-D density functional approximation with general applicability for chemical properties of large systems is proposed. Like B97-D, it is based on Becke's power-series ansatz from 1997 and is explicitly parametrized by including the standard D3 semi-classical dispersion correction. The orbitals are expanded in a modified valence triple-zeta Gaussian basis set, which is available for all elements up to Rn. Remaining basis set errors are mostly absorbed in the modified B97 parametrization, while an established atom-pairwise short-range potential is applied to correct for the systematically too long bonds of main group elements which are typical for most semi-local density functionals...
February 14, 2018: Journal of Chemical Physics
Zeyu Zeng, Xixi Lin, Rongying Zheng, Hui Zhang, Weixi Zhang
Severe airway hyperresponsiveness (AHR) is a clinical feature of asthma, which has been associated with obesity and has shown a poor response to standard asthma treatments such as glucocorticoids. Numerous studies have shown that Interleukin (IL)-17 producing CD4 + T cells (Th17 cells), which could be inhibited by celastrol, is essential in mediating steroid-resistant AHR. The following study investigates the impact of celastrol and its mechanism on the regulation of AHR in murine model of obesity and asthma...
2018: Frontiers in Pharmacology
Maddalena Boccia, Antonella Di Vita, Liana Palermo, Giorgia Committeri, Laura Piccardi, Cecilia Guariglia
The ability of seeing with the mind's eye, the visual mental imagery, is peculiarly compromised in patients with representational neglect. Representational neglect affects the processing of the left side of a mental image and may selectively concern the ability to imagine places and/or objects. Right-brain damaged patients with representational neglect for places (RN+) lose the ability to imagine themselves within a familiar place and fail in transforming an egocentric representation of the environment into an allocentric one and vice-versa...
February 13, 2018: Brain Imaging and Behavior
Mengwen Qi, Chunfeng Wu, Zhouqing Wang, Li Zhou, Chen Men, Yimei Du, Songming Huang, Lei Chen, Ling Chen
BACKGROUND/AIMS: Glycine plays an important role in regulating hippocampal inhibitory/ excitatory neurotransmission through activating glycine receptors (GlyRs) and acting as a co-agonist of N-methyl-d-aspartate-type glutamate receptors. Activation of transient receptor potential vanilloid 4 (TRPV4) is reported to inhibit hippocampal A-type γ-aminobutyric acid receptor, a ligand-gated chloride ion channel. GlyRs are also ligand-gated chloride ion channels and this paper aimed to explore whether activation of TRPV4 could modulate GlyRs...
February 7, 2018: Cellular Physiology and Biochemistry
Jeongshim Lee, Sung Soo Ahn, Jong Hee Chang, Chang Ok Suh
PURPOSE: To evaluate the adequacy of retreatment, including hypofractionated re-irradiation (HFReRT), after surgery for recurrent glioblastoma (GBM) and related prognosticators of outcomes. MATERIALS AND METHODS: From 2011 to 2014, 25 consecutive patients with recurrent (n=17) or secondary (n=7) disease underwent maximal surgery and subsequent HFReRT after meeting the following conditions: 1) confirmation of recurrent or secondary GBM after salvage surgery; 2) Karnofsky performance score (KPS) ≥60; and 3) interval of ≥12 months between initial radiotherapy and HFReRT...
March 2018: Yonsei Medical Journal
Tatiana V Ilchibaeva, Anton S Tsybko, Rimma V Kozhemyakina, Elena M Kondaurova, Nina K Popova, Vladimir S Naumenko
Brain-derived neurotrophic factor (BDNF), its precursor proBDNF, BDNF pro-peptide, BDNF mRNA levels, as well as TrkB and p75NTR receptors mRNA and protein levels, were studied in the brain of rats, selectively bred for more than 85 generations for either the high level or the lack of fear-induced aggressive behavior. Furthermore, we have found that rats of aggressive strain demonstrated both high level of aggression toward humans and increased amplitude of acoustic startle response compared to rats selectively bred for the lack of fear-induced aggression...
February 6, 2018: Behavioural Brain Research
Mary Louise Kanaskie, Cynthia Snyder
AIM: This study explored decision-making regarding use of safe patient handling and mobility (SPHM) technology among registered nurses (RN) and nursing assistants (NA). BACKGROUND: Lifting injuries are common among healthcare workers. Despite development of standards for SPHM, the introduction of regulation for monitoring access to SPHM technology, and implementation of education programs and process improvements, threat of injury remains a concern. Although access to SPHM equipment is associated with decreased workplace injuries, access alone does not guarantee use...
February 2018: Applied Nursing Research: ANR
Laura Stanfield
INTRODUCTION: This quality improvement project compared door-to-electrocardiogram (ECG) times for patients presenting with symptoms suggestive of acute coronary syndrome within a community hospital emergency department before and after first-nurse (emergency nurse stationed in the ED waiting room) training. METHOD: Door-to-ECG time was compared before and after the educational intervention using Acute Coronary Treatment and Intervention Outcomes Network (ACTION) registry data reported by the facility...
February 4, 2018: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
Xiaoyu Li, Lijuan Liu, Huijin Yang, Yan Li
Environmental factors and human activities play important roles in carbon fixation and emissions generated from croplands. Eddy covariance measurements in a drip-irrigated, film-mulched cotton field were used to analyze the relationships between carbon fluxes and environmental factors in Wulanwusu, northern Xinjiang, an arid region of Northwest China. Our results showed that the cumulative net carbon flux (NEE) was -304.8 g C m-2 (a strong sink) over the whole cotton growing season in 2012, which was more than that in cotton cropland without plastic film mulching and drip-irrigation...
2018: PloS One
Lei Chong, Weixi Zhang, Gang Yu, Hailin Zhang, Lili Zhu, Haiyan Li, Youyou Shao, Changchong Li
CD38 is a plasma membrane bound multifunctional enzyme. It can be activated by inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-13, inducing calcium responses to agonist in airway smooth muscle cells (ASMC). Previous studies have found that high-fat-diet (HFD) induced obesity exhibited innate airway hyperresponsiveness (AHR). This study aimed to detect the effect of CD38 signaling pathway on the AHR of overweight/obese mice. The HFD-fed mice exhibited a significantly higher baseline airway resistance (Rn), and the increasing rates of Rn responded to increasing doses of methacholine compared with the LFD-fed mice...
February 1, 2018: International Immunopharmacology
Yi Li, Xiaolong Huang, Jingru Jiang, Weihan Hu, Jiang Hu, Jinhua Cai, Xiaoming Rong, Jinping Cheng, Yongteng Xu, Rong Wu, Jinjun Luo, Yamei Tang
PURPOSE: To identify the predictive and prognostic factors for a decrease or recurrence of brain edema in patients who developed radiation-induced brain necrosis (RN) after radiation therapy for nasopharyngeal carcinoma (NPC) and who received bevacizumab monotherapy. METHODS AND MATERIALS: This was a retrospective study. The charts of 50 patients who were diagnosed with RN after radiation therapy for NPC, treated with bevacizumab, and followed up for 6 months were reviewed...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Karen MacKinnon, Diane L Butcher, Anne Bruce
Work relationships between registered nurses (RNs) and practical nurses (LPNs) are changing as new models of nursing care delivery are introduced to create more flexibility for employers. In Canada, a team-based, hospital nursing care delivery model, known as Care Delivery Model Redesign (CDMR), redesigned a predominantly RN-based staffing model to a functional team consisting of fewer RNs and more LPNs. The scope of practice for LPNs was expanded, and unregulated health care assistants introduced. This study began from the standpoint of RNs and LPNs to understand their experiences working on redesigned teams by focusing on discourses activated in social settings...
January 2018: Global Qualitative Nursing Research
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