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https://www.readbyqxmd.com/read/28821455/rnase-hii-saves-rnha-mutant-escherichia-coli-from-r-loop-associated-chromosomal-fragmentation
#1
Elena A Kouzminova, Farid F Kadyrov, Andrei Kuzminov
The rnhAB mutant E. coli, deficient in two RNase H enzymes that remove both R-loops and incorporated ribonucleotides (rNs) from DNA, grow slowly, suggesting accumulation of rN-containing DNA lesions (R-lesions). We report that the rnhAB mutants have reduced viability, form filaments with abnormal nucleoids, induce SOS and fragment their chromosome, revealing replication and/or segregation stress. R-loops are known to interfere with replication forks, and sensitivity of the double rnhAB mutants to translation inhibition points to R-loops as precursors for R-lesions...
August 15, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28818534/endoscopic-treatment-of-vesicoureteral-reflux-in-infants-can-we-do-it-and-should-we-do-it
#2
Sara Fuentes, Andrés Gómez-Fraile, Isabel Carrillo-Arroyo, Cristina Tordable-Ojeda, Daniel Cabezalí-Barbancho
Objective To evaluate the outcomes of endoscopic treatment of vesicoureteral reflux (VUR) performed on infants, and to discuss the possible role of this approach in selected cases. Material and Methods A retrospective analysis was conducted on the patients that underwent endoscopic injection of a bulking substance for VUR in our institution, and a comparison made with patients treated as infants and those treated later in life. Results A total 463 ureteric units were included (296 children), of which 47 of them were patients less than one year of age (infants, INF group), with the remaining 416 being included in a second group (children, CHL)...
August 14, 2017: Urology
https://www.readbyqxmd.com/read/28817446/bevacizumab-as-an-effective-treatment-for-radiation-necrosis-after-radiotherapy-for-melanoma-brain-metastases
#3
Isabella C Glitza, Nandita Guha-Thakurta, Neil M D'Souza, Rodabe N Amaria, Susan L McGovern, Ganesh Rao, Jing Li
Radiation necrosis (RN) is a potential late complication of radiotherapy for intracranial malignancy, which is often associated with significant neurological morbidity. Prolonged treatment with high-dose corticosteroids or surgical resection has been the standard care for RN, but protracted steroid use can lead to significant side effects and surgical resection is not always feasible. The antivascular endothelial growth factor monoclonal antibody bevacizumab induces clinical and radiographic improvements in RN, with overall good tolerance...
August 16, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28812053/emergency-medical-service-personnel-recognize-pediatric-concussions
#4
Joshua N Speirs, Matthew I Lyons, Bert E Johansson
Concussions are a major cause of morbidity in pediatrics. Many concussions occur during activities with emergency medical service (EMS) providers present to determine if a higher level of care is needed. Data are limited on how capable these providers are. We assessed the ability of EMS providers to recognize pediatric concussions. Fifty-six total responses were included, 38 from EMS and 18 from our MD/RN (medical doctor/registered nurse) group. No statistical differences were found between the 2 groups when adjusted for age, gender, number of years in practice, and number of pediatric concussions managed...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/28811394/overview-and-current-management-of-computerized-adaptive-testing-in-licensing-certification-examinations
#5
Dong Gi Seo
Computerized adaptive testing (CAT) has been implemented in the high stakes examinations such as National Council Licensure Examination-Registered Nurses (NCLEX-RN) in the United States since 1994. After that, The National Registry Emergency Medical Technician (NREMT) in the United States adopted a CAT to certify an Emergency Medical Technician (EMT) in 2007. It aimed at introducing CAT for the implementation in the medical health licensing examinations. Most CATs are based on the item response theory (IRT) which hypothesizes that both examinee and item has own characteristics that does not change...
July 26, 2017: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/28801585/inputs-of-humic-fluorescent-dissolved-organic-matter-via-submarine-groundwater-discharge-to-coastal-waters-off-a-volcanic-island-jeju-korea
#6
Jeonghyun Kim, Guebuem Kim
The abundance of fluorescent dissolved organic matter (FDOM) in the surface ocean plays a critical role in the growth of marine microorganisms and corals by affecting the optical properties (i.e., the penetration of UV radiation) of seawater. In general, it is known that rivers are the main source of FDOM to surface ocean waters. Here, however, we show that the concentrations of FDOM in coastal seawater off a volcanic island, Jeju, Korea, are dependent primarily on submarine groundwater discharge (SGD). Based on a significant correlation between (222)Rn and salinity in seawater, fresh groundwater was found to be the main source of groundwater as well as fresh water in the bay...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801061/european-temporal-trends-in-the-use-of-lymph-node-dissection-in-patients-with-renal-cancer
#7
U Capitanio, G D Stewart, A Larcher, I Ouzaid, B Akdogan, M Roscigno, M Marszalek, P Dell'Oglio, M Salagierski, A Volpe, M C Mir, M Kriegmair, C Terrone, S D Brookman-May, F Montorsi, T Klatte
BACKGROUND: The role of lymph node dissection (LND) in renal cell carcinoma (RCC) is still under debate. We aimed to assess the utilization rates of LND over time in Europe. METHODS: A multi-institutional database of 13,581 RCC patients who underwent radical nephrectomy (RN) or nephron sparing surgery (NSS) between 1988 and 2014 was created within an European consortium. We analysed temporal trends in the frequency of LND by using Joinpoint regression. Logistic regression models were used to identify predictors of LND...
August 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28799876/melanoma-brain-metastasis-the-impact-of-stereotactic-radiosurgery-braf-mutational-status-and-targeted-and-or-immune-based-therapies-on-treatment-outcome
#8
Rupesh Kotecha, Jacob A Miller, Vyshak A Venur, Alireza M Mohammadi, Samuel T Chao, John H Suh, Gene H Barnett, Erin S Murphy, Pauline Funchain, Jennifer S Yu, Michael A Vogelbaum, Lilyana Angelov, Manmeet S Ahluwalia
OBJECTIVE The goal of this study was to investigate the impact of stereotactic radiosurgery (SRS), BRAF status, and targeted and immune-based therapies on the recurrence patterns and factors associated with overall survival (OS) among patients with melanoma brain metastasis (MBM). METHODS A total of 366 patients were treated for 1336 MBMs; a lesion-based analysis was performed on 793 SRS lesions. The BRAF status was available for 78 patients: 35 had BRAF (mut) and 43 had BRAF wild-type ( BRAF-WT) lesions. The Kaplan-Meier method evaluated unadjusted OS; cumulative incidence analysis determined the incidences of local failure (LF), distant failure, and radiation necrosis (RN), with death as a competing risk...
August 11, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28797910/environmental-evaluation-of-natural-radioactivity-in-soil-near-a-lignite-burning-power-plant-in-turkey
#9
E Gören, Ş Turhan, A Kurnaz, A M K Garad, C Duran, F A Uğur, Z Yeğingil
Natural radionuclides are released into the environment together with fly ash from the coal-burning power plant and cause an increase in the natural radioactivity in environmental samples. The study concerns to the evaluation the influence of Kangal lignite-burning power plant (LBPP) with a power of 457 MWe, which has been in operation since 1989, on natural radionuclide a concentration in surface soil samples around it. Activity concentrations of natural radionuclides ((226)Ra, (232)Th, (40)K and (222)Rn) in the soil samples, and emanation coefficient (EC) and mass (ERM) and surface (ERS) exhalation rate of radon were determined by using a gamma-ray spectrometer with an HPGe detector...
August 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28794554/mucocutaneous-manifestations-in-patients-with-rheumatoid-arthritis-a-cross-sectional-study-from-eastern-india
#10
Sudip Kumar Ghosh, Debabrata Bandyopadhyay, Surajit Kumar Biswas, Ivoreen Darung
BACKGROUND: Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease. AIMS: The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India. METHODOLOGY: Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28794220/is-behavioural-plasticity-consistent-across-different-environmental-gradients-and-through-time
#11
David J Mitchell, Peter A Biro
Despite accumulating evidence for individual variation in behavioural plasticity, there is currently little understanding of the causes and consequences of this variation. An outstanding question is whether individual reaction norm (RN) slopes are consistent across different environmental variables-that is, whether an individual that is highly responsive to one environmental variable will be equally responsive to a second variable. Another important and related question is whether RNs are themselves consistently expressed through time or whether they are simply state dependent...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28792193/partial-nephrectomy-for-t3an0m0-renal-cell-carcinoma-shall-we-step-forward
#12
Ding Peng, Zhi-Song He, Xue-Song Li, Qi Tang, Lei Zhang, Kai-Wei Yang, Xiao-Teng Yu, Cui-Jian Zhang, Li-Qun Zhou
OBJECTIVES: To evaluate the prognosis of non-metastatic T3a renal cell carcinoma (RCC) with partial nephrectomy (PN). PATIENTS AND METHODS: We retrospectively evaluated 125 patients with non-metastatic T3a RCC. Patients undergoing PN and radical nephrectomy (RN) were strictly matched by clinic-pathologic characteristics. Log-rank test and Cox regression model were used for univariate and multivariate analysis. RESULTS: 18 pair patients were matched and the median follow-up was 35...
August 8, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28781902/study-on-lesion-assessment-of-cerebello-thalamo-cortical-network-in-wilson-s-disease-with-diffusion-tensor-imaging
#13
Anqin Wang, Hongli Wu, Chunsheng Xu, Lanfeng Tang, Jaeyoun Lee, Min Wang, Man Jiang, Chuanfu Li, Qi Lu, Chunyun Zhang
Wilson's disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and 30 age- and sex-matched healthy volunteers were recruited to accept diffusion-weighted images with 15 gradient vectors and conventional magnetic resonance imaging (MRI). The DTI parameters, including fractional anisotropy (FA) and mean diffusion (MD), were calculated by diffusion kurtosis estimator software...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28776956/first-follow-up-radiographic-response-is-one-of-the-predictors-of-local-tumor-progression-and-radiation-necrosis-after-stereotactic-radiosurgery-for-brain-metastases
#14
Mayur Sharma, Xuefei Jia, Manmeet Ahluwalia, Gene H Barnett, Michael A Vogelbaum, Samuel T Chao, John H Suh, Erin S Murphy, Jennifer S Yu, Lilyana Angelov, Alireza M Mohammadi
Local progression (LP) and radiation necrosis (RN) occur in >20% of cases following stereotactic radiosurgery (SRS) for brain metastases (BM). Expected outcomes following SRS for BM include tumor control/shrinkage, local progression and radiation necrosis. 1427 patients with 4283 BM lesions were treated using SRS at Cleveland Clinic from 2000 to 2012. Clinical, imaging and radiosurgery data were collected from the database. Local tumor progression and RN were the primary end points and correlated with patient and tumor-related variables...
August 4, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28771947/roles-and-functions-of-enrolled-nurses-in-australia-perspectives-of-enrolled-nurses-and-registered-nurses
#15
Ruth Endacott, Margaret O'Connor, Allison Williams, Pamela Wood, Lisa McKenna, Debra Griffiths, Cheryle Moss, Phillip Della, Wendy Cross
AIMS: The aims of the study were: To determine, from the perspectives of Enrolled Nurses (ENs) and Registered Nurses (RNs), the current scope of EN practice and To identify the activities that most ENs frequently performed in their workplace. BACKGROUND: Enrolled Nurse scope of practice in Australia has evolved and expanded over the past decade. However, the unclear role, function and competency differentiation between EN and RN leads to role confusion and ongoing professional debate...
August 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28770542/process-based-treatment-of-diabetes-in-kaiser-permanente-southern-california-how-to-make-diabetes-care-complete
#16
REVIEW
John P Martin, Natalie Aboubechara
PURPOSE OF REVIEW: The purpose of this review was to provide an overview of the Kaiser Permanente Southern California (KPSC) Complete Care management strategy. RECENT FINDINGS: The KPSC Complete Care program allows members of care management teams to coordinate the administration of care for patients with diabetes. This program encompasses teams of physicians, physician assistants, pharmacists, nurse practitioners, registered nurse (RN) care managers, office-based RNs, health educators, and many others to contribute to the glycemic and overall health outcomes for our patients with diabetes...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28770500/loss-of-pericytes-in-radiation-necrosis-after-glioblastoma-treatments
#17
Soon-Tae Lee, Youngbeom Seo, Ji-Yeon Bae, Kon Chu, Jin Wook Kim, Seung Hong Choi, Tae Min Kim, Il Han Kim, Sung-Hye Park, Chul-Kee Park
Radiation necrosis (RN) in brain tumor patients is often symptomatic, persistent without immediate resolution, and confused with tumor recurrence. Cerebral vascular pericytes are essential for endothelial function, vascular integrity, and angiogenesis. In this study, we showed that the loss of pericytes is involved in the pathogenesis of RN. From a brain tumor tissue repository, we identified three patients since 2011 with pathologically confirmed RN after the standard treatment for glioblastoma (GBM). The RN and their preradiation GBM tissues were serially processed for Western blotting using cell-type-specific antibodies against endothelial (CD31, active RhoA), pericyte [platelet-derived growth factor receptor-beta (PDGFR-β)], alpha-smooth muscle actin (α-SMA), astrocyte (GFAP), myelin sheath protein (MBP), and microglial markers (Iba1)...
August 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28768667/trpv4-channels-contribute-to-renal-myogenic-autoregulation-in-neonatal-pigs
#18
Hitesh Soni, Dieniffer Peixoto-Neves, Anberitha T Matthews, Adebowale Adebiyi
Myogenic response, a phenomenon in which resistance size arteries and arterioles swiftly constrict or dilate in response to an acute elevation or reduction, respectively in intravascular pressure is a key component of renal autoregulation mechanisms. Although it is well-established that the renal system is functionally immature in neonates, mechanisms that regulate neonatal renal blood flow (RBF) remain poorly understood. In this study, we investigated the hypothesis that members of the transient receptor potential vanilloid (TRPV) channels are molecular components of renal myogenic constriction in newborns...
August 2, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28762737/mngcch-m-cu-ag-au-ng-xe-rn-the-first-set-of-compounds-with-m-ng-c-bonding-motif
#19
Gourhari Jana, Sudip Pan, Gabriel Merino, Pratim K Chattaraj
Although Ng-M (M = Cu, Ag, Au; Ng = noble gas) and Ng-C bonds are known to exist in different viable species, we report here a series of systems with formula MNgCCH (Ng = Xe, Rn) in which both bonds coexist. These compounds possess reasonably high kinetic stability (free energy barrier, ΔG(‡) of 14.0-34.8 kcal/mol) along an exergonic isomerization channel, MNgCCH → NgMCCH. For a given M, the ΔG(‡) associated with this channel increases from Xe to Rn, whereas for a given Ng, it increases along Ag < Cu < Au...
August 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28760509/pulmonary-mechanic-and-lung-histology-induced-by-crotalus-durissus-cascavella-snake-venom
#20
Joselito de Oliveira Neto, João Alison de Moraes Silveira, Daniel Silveira Serra, Daniel de Araújo Viana, Diva Maria Borges-Nojosa, Célia Maria Souza Sampaio, Helena Serra Azul Monteiro, Francisco Sales Ávila Cavalcante, Janaina Serra Azul Monteiro Evangelista
This study have analyzed the pulmonary function in an experimental model of acute lung injury, induced by the Crotalus durissus cascavella venom (C. d. cascavella) (3.0 μg/kg - i.p), in pulmonary mechanic and histology at 1 h, 3 h, 6 h, 12 h and 24 h after inoculation. The C. d. cascavella venom led to an increase in Newtonian Resistance (RN), Tissue Resistance (G) and Tissue Elastance (H) in all groups when compared to the control, particularly at 12 h and 24 h. The Histeresivity (η) increased 6 h, 12 h and 24 h after inoculation...
July 28, 2017: Toxicon: Official Journal of the International Society on Toxinology
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