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Antidepressants anxiety

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https://www.readbyqxmd.com/read/28636769/is-cannabis-treatment-for-anxiety-mood-and-related-disorders-ready-for-prime-time
#1
REVIEW
Jasmine Turna, Beth Patterson, Michael Van Ameringen
Anxiety and related disorders are the most common mental conditions affecting the North American population. Despite their established efficacy, first-line antidepressant treatments are associated with significant side effects, leading many afflicted individuals to seek alternative treatments. Cannabis is commonly viewed as a natural alternative for a variety of medical and mental health conditions. Currently, anxiety ranks among the top five medical symptoms for which North Americans report using medical marijuana...
June 21, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28636131/state-trait-and-dental-anxiety-in-caregivers-of-individuals-with-disabilities
#2
Roberto Carlos Mourão Pinho, André Cavalcante da Silva Barbosa, Arnaldo de França Caldas-Júnior, Márcia Maria Vendiciano Barbosa Vasconcelos, Renata Cimões, Maria Teresa Botti Rodrigues Dos Santos
PURPOSE: The aim of this study was to compare state anxiety, trait anxiety, and dental anxiety in caregivers of patients with special needs and caregivers of pediatric patients without special needs at dental clinics. MATERIALS AND METHODS: A quantitative, cross-sectional study was conducted. Data were collected using a semistructured questionnaire. All respondents were older than 18 years of age. Individuals with cognitive impairment and those taking anxiolytics, antidepressants, or sleep-inducing medication were excluded from the study...
June 21, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/28635531/drug-exposure-in-early-pregnancy-might-be-related-to-the-effects-of-increased-maternal-progesterone-in-implantation-period
#3
Necip Girit, Ibrahim Tugrul, Buket Demirci, Ozlem Bozkurt, Turhan Dost, Mustafa Birincioglu, H Alper Tanriverdi
AIM: This short communication aims to evaluate the relation in between drug exposure time and early pregnancy regarding gestational weeks. METHODS: The study covers the referrals made to the Department of Pharmacology for a teratogenic consultation in a 3-year period. From the recordings of pregnant women, the last menstrual period and the starting date of medication were used to determine the time of prescription with regard to gestational weeks. RESULTS: In all of the three years, potentially teratogenic medication was prescribed more frequently in the 3rd, 4th and 5th gestational weeks (in between 15-35 days of pregnancy)...
February 15, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28632893/atopic-dermatitis-is-associated-with-anxiety-depression-and-suicidal-ideation-but-not-with-hospitalization-or-suicide
#4
Jacob P Thyssen, Carsten R Hamann, Allan Linneberg, Thomas Meinertz Dantoft, Lone Skov, Gunnar H Gislason, Jashin J Wu, Alexander Egeberg
BACKGROUND: Atopic dermatitis (AD) has been linked with psychiatric disease in adults. However, the exact relationship and its consequences have been insufficiently studied. Our aim in this study was to assess the association between depression, anxiety and AD in adults, and examine the risk of hospitalization and suicide. METHODS: We utilized questionnaire data from a large general population study with data on social habits and psychiatric symptoms to compare prevalences of depression, anxiety, suicidal ideation, and anxiety attacks, in adults with and without a history of AD...
June 20, 2017: Allergy
https://www.readbyqxmd.com/read/28629963/environmental-enrichment-reduces-innate-anxiety-with-no-effect-on-depression-like-behaviour-in-mice-lacking-the-serotonin-transporter
#5
Jake Rogers, Shanshan Li, Laurence Lanfumey, Anthony J Hannan, Thibault Renoir
Along with being the main target of many antidepressant medications, the serotonin transporter (5-HTT) is known to be involved in the pathophysiology of depression and anxiety disorders. In line with this, mice with varying 5-HTT genotypes are invaluable tools to study depression- and anxiety-like behaviours as well as the mechanisms mediating potential therapeutics. There is clear evidence that both genetic and environmental factors play a role in the aetiology of psychiatric disorders. In that regard, housing paradigms which seek to enhance cognitive stimulation and physical activity have been shown to exert beneficial effects in animal models of neuropsychiatric disorders...
June 16, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28628765/emotional-blunting-with-antidepressant-treatments-a-survey-among-depressed-patients
#6
G M Goodwin, J Price, C De Bodinat, J Laredo
BACKGROUND: Emotional blunting is regularly reported in depressed patients on antidepressant treatment but its actual frequency is poorly understood. We have previously used qualitative methods to develop an appropriate scale, the Oxford Questionnaire on the Emotional Side-Effects of Antidepressants (OQESA). METHODS RESULTS: Six hundred and sixty nine depressed patients on treatment and 150 recovered (formerly depressed) controls (aged ≥18 years) participated in this internet-based survey...
June 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28627912/cognitive-behavioral-versus-psychodynamic-therapy-for-major-depression-secondary-outcomes-of-a-randomized-clinical-trial
#7
Ellen Driessen, Henricus L Van, Jaap Peen, Frank J Don, Jos W R Twisk, Pim Cuijpers, Jack J M Dekker
OBJECTIVE: In a randomized clinical trial, we compared the efficacy of cognitive-behavioral therapy (CBT) and psychodynamic therapy for adult outpatient depression on measures of psychopathology, interpersonal functioning, pain, and quality of life. METHOD: There were 341 Dutch adults (70.1% female, mean age = 38.9, SD = 10.3) meeting Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition (DSM-IV) criteria for a major depressive episode and with a Hamilton Depression Rating Scale (HAM-D) score ≥14, who were randomized to 16 sessions of individual manualized CBT or short-term psychodynamic supportive psychotherapy...
July 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28623361/burden-of-sleep-disturbances-and-associated-risk-factors-a-cross-sectional-survey-among-hiv-infected-persons-on-antiretroviral-therapy-across-china
#8
Xiaojie Huang, Huiqin Li, Kathrine Meyers, Wei Xia, Zhihao Meng, Chongxi Li, Jinsong Bai, Shenghua He, Weiping Cai, Chengyu Huang, Shuiqing Liu, Hui Wang, Xuemei Ling, Ping Ma, Daling Tan, Fuxiang Wang, Lianguo Ruan, Hongxin Zhao, Hongxia Wei, Yanfen Liu, Jianhua Yu, Hongzhou Lu, Min Wang, Tong Zhang, Hui Chen, Hao Wu
This study evaluated the prevalence and factors associated with sleep disturbance in a large cohort of HIV-infected patients across China. A cross-sectional study was conducted among HIV-infected patients on antiretroviral therapy at 20 AIDS clinics. The Pittsburgh Sleep Quality Index was self-administered by subjects. Socio-demographic characteristics, medical history and HIV-related clinical data were collected. 4103 patients had complete data for analysis. Sleep disturbances were observed in 43.1% of patients...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28594546/neuropeptide-vgf-c-terminal-peptide-tlqp-62-alleviates-lipopolysaccharide-induced-memory-deficits-and-anxiety-like-and-depression-like-behaviors-in-mice-the-role-of-bdnf-trkb-signaling
#9
Chenli Li, Mengmeng Li, Hanjie Yu, Xinbei Shen, Jinting Wang, Xin Sun, Qinwen Wang, Chuang Wang
Peripheral inflammatory responses affect central nervous system (CNS) function, manifesting in symptoms of memory deficits, depression, and anxiety. Previous studies have revealed that neuropeptide VGF (nonacronymic) C-terminal peptide TLQP-62 rapidly reinforces brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB) signaling, regulating memory consolidation and antidepressant-like action. However, whether it is beneficial for lipopolysaccharide (LPS)-induced neuropsychiatric dysfunction in mice is unknown...
June 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28593516/antidepressant-and-anxiolytic-effects-of-garcinia-indica-fruit-rind-via-monoaminergic-pathway
#10
Isha Dhamija, Milind Parle, Sandeep Kumar
Depression and anxiety are the most crippling neuropsychiatric disorders of this modern era. These mostly occur as anxiety followed by depression or in mixed state. Therefore, there is an urgent need of a safe and effective treatment, which proves its worth in this ailment. What else than a conventional food would be a better choice for a convenient therapy. Therefore, Garcinia indica, commonly known as Kokam, fruit rind has been used in the present study to investigate its antidepressant and anti-anxiety potential using forced swim test, tail suspension test, and reserpine-induced hypothermia; and elevated plus maze, hole-board test, and light dark model, respectively...
June 2017: 3 Biotech
https://www.readbyqxmd.com/read/28593281/simultaneous-antidepressant-and-benzodiazepine-new-use-and-subsequent-long-term-benzodiazepine-use-in-adults-with-depression-united-states-2001-2014
#11
Greta A Bushnell, Til Stürmer, Bradley N Gaynes, Virginia Pate, Matthew Miller
Importance: Benzodiazepines have been prescribed for short periods to patients with depression who are beginning antidepressant therapy to improve depressive symptoms more quickly, mitigate concomitant anxiety, and improve antidepressant treatment continuation. However, benzodiazepine therapy is associated with risks, including dependency, which may take only a few weeks to develop. Objectives: To examine trends in simultaneous benzodiazepine and antidepressant new use among adults with depression initiating an antidepressant, assess antidepressant treatment length by simultaneous new use status, estimate subsequent long-term benzodiazepine use in those with simultaneous antidepressant and benzodiazepine new use, and identify determinants of simultaneous new use and long-term benzodiazepine use...
June 7, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28591669/bupropion-induces-social-anxiety-in-adolescent-mice-influence-of-housing-conditions
#12
Carmen Gómez, Rosa Redolat, Carmen Carrasco
BACKGROUND: The antidepressant bupropion has received increasing attention as a pharmacological tool to treat addiction although little is known about its effects on social behaviour in adolescents. The present study aimed to evaluate if environmental housing conditions influence bupropion's actions on social behaviour of adolescent mice. METHODS: Mice were either group- or individually housed for 2-weeks and then randomly divided into 2 cohorts: half of the mice remained in the initial housing condition and the other half were changed to isolated conditions for further 2-weeks...
March 22, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28588898/gender-alexithymia-and-physical-inactivity-associated-with-abdominal-obesity-in-type-1-diabetes-mellitus-a-cross-sectional-study-at-a-secondary-care-hospital-diabetes-clinic
#13
Eva O Melin, Ralph Svensson, Maria Thunander, Magnus Hillman, Hans O Thulesius, Mona Landin-Olsson
BACKGROUND: Obesity is linked to cardiovascular diseases and increasingly common in type 1 diabetes mellitus (T1DM) since the introduction of intensified insulin therapy. Our main aim was to explore associations between obesity and depression, anxiety, alexithymia and self-image measures and to control for lifestyle variables in a sample of persons with T1DM. Secondary aims were to explore associations between abdominal and general obesity and cardiovascular complications in T1DM. METHODS: Cross sectional study of 284 persons with T1DM (age 18-59 years, men 56%), consecutively recruited from one secondary care hospital diabetes clinic in Sweden...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28588483/plastic-and-neuroprotective-mechanisms-involved-in-the-therapeutic-effects-of-cannabidiol-in-psychiatric-disorders
#14
REVIEW
Alline C Campos, Manoela V Fogaça, Franciele F Scarante, Sâmia R L Joca, Amanda J Sales, Felipe V Gomes, Andreza B Sonego, Naielly S Rodrigues, Ismael Galve-Roperh, Francisco S Guimarães
Beneficial effects of cannabidiol (CBD) have been described for a wide range of psychiatric disorders, including anxiety, psychosis, and depression. The mechanisms responsible for these effects, however, are still poorly understood. Similar to clinical antidepressant or atypical antipsychotic drugs, recent findings clearly indicate that CBD, either acutely or repeatedly administered, induces plastic changes. For example, CBD attenuates the decrease in hippocampal neurogenesis and dendrite spines density induced by chronic stress and prevents microglia activation and the decrease in the number of parvalbumin-positive GABA neurons in a pharmacological model of schizophrenia...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28587819/prodepressant-and-anxiogenic-like-effects-of-serotonin-selective-but-not-noradrenaline-selective-antidepressant-agents-in-mice-lacking-%C3%AE-2-containing-gabaa-receptors
#15
Rebecca S Benham, Nishani B Hewage, Raymond F Suckow, Elif Engin, Uwe Rudolph
Deficits in neuronal inhibition via gamma-aminobutyric acid (GABA) type A receptors (GABAA-Rs) are implicated in the pathophysiology of major depressive disorder and the therapeutic effects of current antidepressant treatments, however, the relevant GABAA-R subtype as defined by its alpha subunit is still unknown. We previously reported anxiety- and depressive-like behavior in alpha2+/- and alpha2-/- mice, respectively (Vollenweider, 2011). We sought to determine whether this phenotype could be reversed by chronic antidepressant treatment...
June 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28584650/are-men-under-treated-and-women-over-treated-with-antidepressants-findings-from-a-cross-sectional-survey-in-sweden
#16
Lena Thunander Sundbom, Kerstin Bingefors, Kerstin Hedborg, Dag Isacson
Aims and method To examine gender differences in self-reported depression and prescribed antidepressants (ADs). The Hospital Anxiety and Depression Scale was used to assess depression, and information on prescribed ADs was obtained from the Swedish Prescribed Drug Register. Results Depression was reported by 11.7% of the participants (12.3% men and 11.2% women). ADs were prescribed for 7.6% of the participants (5.3% men, 9.8% women). Among men, 1.8% reported depression and used ADs, 10.5% reported depression but did not use ADs, and 3...
June 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28584640/chlorpheniramine-and-escitalopram-similar-antidepressant-and-nitric-oxide-lowering-roles-in-a-mouse-model-of-anxiety
#17
Omar Gammoh, Fadia Mayyas, Feras Darwish Elhajji
There is a crosstalk between mood disorders and oxidative stress. Chlorpheniramine (CPA), a first generation antihistamine, is hypothesized to have an anxiolytic role at high doses; however, its antidepressant and antioxidant roles have not previously been investigated. The aim of the current study was to evaluate the antidepressant and anxiolytic effects of CPA treatment in association with nitric oxide (NO) and super oxide dismutase (SOD) activity in a mouse model of anxiety. BALB/c mice were divided into unstressed (naïve), control, and CPA- (0...
June 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28581025/clinical-characteristics-and-treatment-patterns-among-patients-diagnosed-with-cluster-headache-in-u-s-healthcare-claims-data
#18
Casey K Choong, Janet H Ford, Allen W Nyhuis, Shivang G Joshi, Rebecca L Robinson, Sheena K Aurora, James M Martinez
OBJECTIVE: To characterize demographics, clinical characteristics, and treatment patterns of patients with cluster headache (CH). BACKGROUND: CH is an uncommon trigeminal autonomic cephalalgia with limited evidence-based treatment options. Patients suffer from extremely painful unilateral headache attacks and autonomic symptoms with episodic and chronic cycles. DESIGN/METHODS: This retrospective analysis used insurance claims from Truven Health Analytics MarketScan(®) research databases from 2009 to 2014...
June 5, 2017: Headache
https://www.readbyqxmd.com/read/28579958/exploring-pharmacological-mechanisms-of-lavender-lavandula-angustifolia-essential-oil-on-central-nervous-system-targets
#19
Víctor López, Birgitte Nielsen, Maite Solas, Maria J Ramírez, Anna K Jäger
Lavender essential oil is traditionally used and approved by the European Medicines Agency (EMA) as herbal medicine to relieve stress and anxiety. Some animal and clinical studies reveal positive results in models of anxiety and depression although very little research has been done on molecular mechanisms. Our work consisted of evaluating the effects of lavender (Lavandula angustifolia) essential oil on central nervous system well-established targets, such as MAO-A, SERT, GABAAand NMDA receptors as well as in vitro models of neurotoxicity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28578592/adjunctive-minocycline-treatment-for-major-depressive-disorder-a-proof-of-concept-trial
#20
Olivia M Dean, Buranee Kanchanatawan, Melanie Ashton, Mohammadreza Mohebbi, Chee Hong Ng, Michael Maes, Lesley Berk, Atapol Sughondhabirom, Sookjaroen Tangwongchai, Ajeet B Singh, Helen McKenzie, Deidre J Smith, Gin S Malhi, Nathan Dowling, Michael Berk
OBJECTIVE: Conventional antidepressant treatments result in symptom remission in 30% of those treated for major depressive disorder, raising the need for effective adjunctive therapies. Inflammation has an established role in the pathophysiology of major depressive disorder, and minocycline has been shown to modify the immune-inflammatory processes and also reduce oxidative stress and promote neuronal growth. This double-blind, randomised, placebo-controlled trial examined adjunctive minocycline (200 mg/day, in addition to treatment as usual) for major depressive disorder...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
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