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https://www.readbyqxmd.com/read/29338537/antidepressant-prescriptions-and-mental-health-nurses-an-observational-study-in-dutch-general-practice-from-2011-to-2015
#1
Tessa Magnée, Derek P de Beurs, Francois G Schellevis, Peter F Verhaak
PURPOSE: The purpose of this study was to investigate developments in antidepressant prescriptions by Dutch general practitioners, alongside the national introduction of mental health nurses. Antidepressant prescriptions are very common in general practice, but are often not in line with recommendations. The recent introduction of mental health nurses may have decreased antidepressant prescriptions, as general practitioners (GPs) have greater potential to offer psychological treatment as a first choice option instead of medication...
January 17, 2018: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29337001/antidepressant-treatment-duration-in-pediatric-depressive-and-anxiety-disorders-how-long-is-long-enough
#2
Elizabeth E Hathaway, John T Walkup, Jeffrey R Strawn
Anxiety and depressive disorders are common in the pediatric primary care setting, and respond to both psychotherapeutic and psychopharmacologic treatment. However, there are limited data regarding the optimal treatment duration. This article systematically reviews guidelines and clinical trial data related to antidepressant treatment duration in pediatric patients with depressive and anxiety disorders. The extant literature suggests 9-12 months of antidepressant treatment for youth with major depressive disorder...
January 11, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29330217/a-systematic-review-of-network-meta-analyses-for-pharmacological-treatment-of-common-mental-disorders
#3
REVIEW
Taryn Williams, Dan J Stein, Jonathan Ipser
QUESTION: Network meta-analyses (NMAs) of treatment efficacy across different pharmacological treatments help inform clinical decision-making, but their methodological quality may vary a lot depending also on the quality of the included primary studies. We therefore conducted a systematic review of NMAs of pharmacological treatment for common mental disorders in order to assess the methodological quality of these NMAs, and to relate study characteristics to the rankings of efficacy and tolerability...
January 12, 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29330035/harmine-enhances-gabaergic-transmission-onto-basoamygdala-projection-neurons-in-mice
#4
Wei-Zhu Liu, Bo-Wei Huang, Wen-Jie You, Ping Hu, Xue-Hui Wang, Jun-Yu Zhang, Xiao-Bin Xu, Zong-Yong Zhang, Bing-Xing Pan, Wen-Hua Zhang
Emerging evidence indicates that loss of inhibitory tone in amygdala with its subsequent overactivation contributes to the development of multiple mental disorders such as anxiety disorders and post-traumatic stress disorder (PTSD). Harmine is a member of natural β-carboline alkaloids which can readily cross the blood brain barrier and displays significant antidepressant and anxiolytic effects in rodents. However, the underlying neurobiological mechanisms are largely unknown. Here, by using whole-cell patch clamp recordings in in vitro amygdala slices, we examined the effect of harmine on glutamatergic and GABAergic transmission onto basal amygdala (BA) projection neurons (PNs)...
January 9, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29328454/resveratrol-ameliorates-depressive-disorder-through-the-netrin1-mediated-extracellular%C3%A2-signal-regulated-kinase-camp-signal-transduction-pathway
#5
Feifei Wang, Jinhui Wang, Jinghong An, Guoming Yuan, Xiaolei Hao, Yi Zhang
Depressive disorder is a mental health disorder caused by the dysfunction of nerve regeneration, neuroendocrine and neurobiochemistry, which frequently results in cognitive impairments and disorder. Evidence has shown that resveratrol offers benefits for the treatment of depressive disorder. In the present study, the therapeutic effects of resveratrol were investigated and the potential mechanisms mediated by resveratrol were analyzed in hippocampal neuron cells. The anti‑oxidative stress and anti‑inflammatory properties of resveratrol were also examined in vitro and in vivo...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327213/add-on-treatment-with-curcumin-has-antidepressive-effects-in-thai-patients-with-major-depression-results-of-a-randomized-double-blind-placebo-controlled-study
#6
Buranee Kanchanatawan, Sookjaroen Tangwongchai, Atapol Sughondhabhirom, Siriluck Suppapitiporn, Solaphat Hemrunrojn, André F Carvalho, Michael Maes
Activation of immune-inflammatory and oxidative-nitrosative (IO&NS) stress pathways plays a role in major depression (MDD). Evidence suggests that curcumin (500-1000 mg/day), a polyphenol with strong anti-IO&NS properties, may have efficacy either as monotherapy or as an adjunctive treatment for depression. Further controlled trials with extended treatment periods (> 8 weeks) and higher curcumin doses are warranted. This 12-week study was carried out to examine the effects of adjunctive curcumin for the treatment of MDD...
January 11, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29325238/psychometrics-of-the-self-report-concise-associated-symptoms-tracking-scale-cast-sr-results-from-the-stride-ctn-0037-study
#7
Joseph M Trombello, Michael O Killian, Allen Liao, Katherine Sanchez, Tracy L Greer, Robrina Walker, Bruce Grannemann, Chad D Rethorst, Thomas Carmody, Madhukar H Trivedi
OBJECTIVE: The self-report Concise Associated Symptoms Tracking Scale (CAST-SR) was developed to track mania, irritability, anxiety, panic, and insomnia symptoms among depressed outpatients receiving antidepressant medication. Given the overlap between these domains, depression, and stimulant use disorders, we reexamined CAST-SR psychometrics in a novel sample: individuals with stimulant use disorder receiving aerobic exercise or health education interventions. METHODS: Using the subsample of stimulant-dependent (following DSM-IV criteria) individuals prescribed antidepressants (N = 124) from the multisite Stimulant Reduction Intervention Using Dosed Exercise (CTN-0037) trial (total sample N = 302), conducted July 2010 to February 2013, we analyzed CAST-SR data collected at the first assessment after participant's discharge from residential treatment...
January 9, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29319248/detection-management-approach-of-depression-and-antidepressant-utilization-in-adult-patients-results-of-a-cross-sectional-survey
#8
Sanket Newale, Deepak S Bachani
Aim: The study was conducted to understand the demographics, prevalence of co-morbid conditions and treatment modalities of depression. Methods: A cross-sectional, nationwide observational study was conducted to understand the management pattern of depression in India. Depression was majorly diagnosed with DSM-IV TR criteria. Results: The data of 2276 Indian patients across 18 states were collected through 135 mental health professionals. The study population was predominantly from urban (81...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29315742/depression-and-anxiety-like-behaviour-is-related-to-bdnf-trkb-signalling-in-a-mouse-model-of-psoriasis
#9
W JiaWen, S Hong, X ShengXiang, L Jing
BACKGROUND: The prevalence of anxiety and depression is significantly higher in individuals with psoriasis than in the general population. Clinical data also show that anti-anxiety and antidepression drugs can reduce skin lesions in patients with psoriasis, but the actual mechanism is still poorly understood. AIM: To investigate whether brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrKB) signalling plays a role in the mechanism underlying psoriasis with depression and anxiety behaviours...
January 8, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29302750/decreased-plasma-agmatine-levels-in-autistic-subjects
#10
Erman Esnafoglu, İlhan İrende
Agmatine is a polyamine endogenously synthesized from arginine and is considered to be a new neurotransmitter. Agmatine has been implicated in the pathophysiology of several diseases such as anxiety disorder, depression, and schizophrenia. Agmatine also possesses anticonvulsant, neuroprotective, antiapoptotic, antioxidant, anxiolytic, and antidepressant effects. Furthermore, agmatine inhibits the nitric oxide synthase enzyme and exerts antagonist effects on NMDA, alpha-2, and imidazoline receptors. Considering these characteristics, the present study investigated whether agmatine plays a role in the pathogenesis of autistic spectrum disorders (ASDs)...
January 4, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29302190/plasma-complement-component-4-increases-in-patients-with-major-depressive-disorder
#11
Jinxue Wei, Ye Liu, Liansheng Zhao, Xiao Yang, Peiyan Ni, Yingcheng Wang, Tao Li, Xiaohong Ma
Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The recent findings that complement component 4 (C4) was involved in neural synapse elimination and associated with schizophrenia implicated the potential roles of C4 in MDD. In this study, we analyzed the plasma concentration of complement C4 and inflammatory factors, including interleukin (IL)-1β, IL-6, IL-8, IL-10, interferon-α, interferon-γ and tumor necrosis factor-α, of 53 patients with MDD and 60 healthy individuals...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29299728/psychopharmacology-utilization-among-children-with-anxiety-and-obsessive-compulsive-and-related-disorders-following-hurricane-katrina
#12
Eric A Storch, Sean Gregory, Alison Salloum, Troy Quast
This study aimed to examine the impact of Hurricane Katrina exposure on medication utilization among children with pre-existing anxiety and obsessive-compulsive and related disorders (OCRDs). Medicaid claims data from 2004 to 2006 were analyzed. Children with pre-existing anxiety/OCRDs were compared as a function of those living in a Louisiana disaster area, Louisiana non-disaster area, or Texas in terms of filled prescriptions and average days medication supply. This was further examined as a function of disorder/medication type...
January 3, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29298284/adherence-self-stigma-and-discontinuation-of-pharmacotherapy-in-patients-with-anxiety-disorders-cross-sectional-study
#13
Andrea Cinculova, Jan Prasko, Dana Kamaradova, Marie Ociskova, Klara Latalova, Kristyna Vrbova, Radim Kubinek, Barbora Mainerova, Ales Grambal, Anezka Tichackova
INTRODUCTION: Treatment adherence is one of the main factors affecting the success of treatment and, secondarily, the quality of life and social adaptation of the patients. The aim of this study was to investigate the association between self-stigmatization, treatment adherence and history of discontinuation of drug treatment. METHODS: The cross-sectional study was conducted on 120 (98 completed all the questionnaires) neurotic outpatients treated in the University Hospital Olomouc...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29289374/safety-of-flibanserin-in-women-treated-with-antidepressants-a-randomized-placebo-controlled-study
#14
Anita H Clayton, Harry A Croft, James Yuan, Louise Brown, Robert Kissling
BACKGROUND: Depression is often associated with sexual dysfunction, and pharmacologic treatment for hypoactive sexual desire disorder can be considered in women receiving treatment for depression. AIM: To evaluate the safety of flibanserin in women treated for depression with selective serotonin reuptake inhibitors or serotonin and norepinephrine reuptake inhibitors. METHODS: In this double-blinded, randomized, placebo-controlled trial, women with remitted or mild depression treated with selective serotonin reuptake inhibitors or serotonin and norepinephrine reuptake inhibitors who were not postmenopausal and were experiencing symptoms of hypoactive sexual desire disorder (ie, decreased sexual desire and related distress) received flibanserin 50 mg at bedtime (qhs) for 2 weeks and up-titrated to 100 mg qhs, flibanserin 100 mg qhs for the entire treatment period, or placebo for up to 12 weeks...
January 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29283067/safety-limits-of-antidepressant-use-plus-combinations-focus-on-cardiovascular-function
#15
Florindo Stella, Julia C Loureiro, Marcos V Pais, Paulo R Canineu, Orestes V Florenza
BACKGROUND: Antidepressants have been widely prescribed for depression, anxiety, sleep disorders, and in the management of behavioural symptoms of adult-old patients. Although generally safe, newer generation antidepressants are not devoid of the risk of inducing clinically relevant adverse events. OBJECTIVES: To investigate the association between newer generation antidepressants and the occurrence of cardiovascular adverse events and electrocardiogram (ECG) abnormalities...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29275206/chronic-treatment-with-fluoxetine-or-clozapine-of-socially-isolated-rats-prevents-subsector-specific-reduction-of-parvalbumin-immunoreactive-cells-in-the-hippocampus
#16
Dragana Filipović, Andrijana Stanisavljević, Nebojša Jasnić, Rick E Bernardi, Dragos Inta, Ivana Perić, Peter Gass
The dysfunction of parvalbumin-positive (PV+) interneurons, the most abundant type of hippocampal GABAergic inhibitory interneuron, has been implicated in mood disorders. We recently reported that adult male Wistar rats exposed to three weeks of social isolation show depressive- and anxiety-like behaviors and a reduced number of PV+ interneurons in all hippocampal subregions. As GABA neurotransmission has been proposed as a potential therapeutic target of antidepressant and antipsychotic medications, we examined whether treatment with the antidepressant fluoxetine (15 mg/kg/day) or the antipsychotic clozapine (20 mg/kg/day) during three weeks of social isolation in rats offered protection from the isolation stress-induced reduction in the number of PV+ interneurons in hippocampal subregions...
December 21, 2017: Neuroscience
https://www.readbyqxmd.com/read/29274375/meta-analysis-risk-of-dry-mouth-with-second-generation-antidepressants
#17
Kiley Cappetta, Chad Beyer, Jessica A Johnson, Michael H Bloch
OBJECTIVE: The goal of this meta-analysis was to quantify the risk of dry mouth associated with commonly prescribed antidepressant agents and examine the potential implications of medication class, dose, and pharmacodynamics and dose on risk of treatment-induced dry mouth. DATA SOURCES AND STUDY SELECTION: A PubMed search was conducted to identify double-blind, randomized, placebo-controlled trials examining the efficacy and tolerability of second generation antidepressant medications for adults with depressive disorders, anxiety disorders, and OCD...
December 20, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29247629/anxiolytic-and-antidepressant-like-actions-of-urocortin-2-and-its-fragments-in-mice
#18
Zsolt Bagosi, Krisztina Csabafi, Beáta Balangó, Dávid Pintér, Orsolya Szolomájer-Csikós, Zsolt Bozsó, Gábor Tóth, Gyula Telegdy, Gyula Szabó
The aim of the present study was to investigate the potential anxiolytic- and antidepressant-like actions of Urocortin 2 (Ucn2) and its two fragments, Ucn2 (1-21) and Ucn2 (22-38), in mice, in an attempt to identify the biologically active sequence of this 38 amino acid neuropeptide. In this purpose, male C57BL/6 mice were treated intracerebroventricularly (icv) with 0.125, 0.25, 0.5 and 1 µg/2µl of Ucn2, Ucn2 (1-21) or Ucn2 (22-38). After 30 minutes, the mice were evaluated in an elevated plus-maze test and a forced swim test for anxiety- and depression-like behavior, respectively...
December 13, 2017: Brain Research
https://www.readbyqxmd.com/read/29245092/predictors-of-hospitalization-length-of-stay-among-re-admitted-treatment-resistant-bipolar-disorder-inpatients
#19
M Fornaro, F Iasevoli, S Novello, A Fusco, A Anastasia, D De Berardis, A Valchera, A de Bartolomeis
BACKGROUND: Hospitalization accounts for significant health care resource utilization for treatment-resistant Bipolar Disorder (BD), especially among frequent users of acute inpatient psychiatric units. Appraisal of the clinical features and predictive role of selected variables is therefore crucial in such population, representing the aim of the present research. METHODS: A hundred and nineteen BD inpatients with an established history of pharmacological treatment resistance for either mania or bipolar depression were classified as long hospitalization cases (LOS+) and their controls and compared against each other for a number of demographic, clinical, and psychopathological features...
December 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29244063/maternal-psychosocial-stress-associates-with-increased-risk-of-asthma-development-in-offspring
#20
Maria C Magnus, Rosalind J Wright, Espen Røysamb, Christine L Parr, Øystein Karlstad, Christian M Page, Per Nafstad, Siri E Håberg, Stephanie J London, Wenche Nystad
Prenatal maternal psychosocial stress might influence childhood asthma development. Evaluating paternal psychosocial stress and conducting a sibling comparison could provide further insight into the role of unmeasured confounding. We examined the associations of parental psychosocial stress during and after pregnancy with asthma at 7 years in the Norwegian Mother and Child Cohort Study (n = 63,626). Measures of psychosocial stress included lifetime major depressive symptoms, current anxiety/depression symptoms, use of antidepressants, anxiolytics and/or hypnotics, life satisfaction, relationship satisfaction, work stress and social support...
December 13, 2017: American Journal of Epidemiology
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