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https://www.readbyqxmd.com/read/29136602/saffron-in-the-treatment-of-depression-anxiety-and-other-mental-disorders-current-evidence-and-potential-mechanisms-of-action
#1
REVIEW
Mojtaba Shafiee, Soheil Arekhi, Alireza Omranzadeh, Amirhossein Sahebkar
BACKGROUND: Depression and anxiety are two common mental health problems with high economic and social costs. Currently, a number of treatments are available for patients with depression and anxiety disorders such as psychotherapy, electroconvulsive therapy and antidepressant drugs. Due to safety concerns, adverse effects, limited efficacy and low tolerability associated with many antidepressant and anti-anxiety medications, identification of novel agents with less toxicity and more favorable outcome is warranted...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29131110/long-term-and-short-term-antidepressant-use-in-general-practice-data-from-a-large-cohort-in-the-netherlands
#2
Klaas M Huijbregts, AdriaanW Hoogendoorn, Paulien Slottje, Anton J L M van Balkom, Neeltje M Batelaan
BACKGROUND: Antidepressant use is highly prevalent. Research has mainly focused on efficacy during short periods of use for depression and anxiety. There is a relative paucity of data regarding the frequency of long-term use. METHODS: To determine the prevalence and possible increase of long-term use of antidepressants over recent years, we analyzed routine general practice care data in a large cohort of patients (n = 156,620) in and around Amsterdam, The Netherlands...
November 3, 2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29128806/emotional-disorders-induced-by-hemopressin-and-rvd-hemopressin-%C3%AE-administration-in-rats
#3
Sheila Leone, Lucia Recinella, Annalisa Chiavaroli, Sara Martinotti, Claudio Ferrante, Adriano Mollica, Giorgia Macedonio, Azzurra Stefanucci, Szabolcs Dvorácskó, Csaba Tömböly, Luciano De Petrocellis, Michele Vacca, Luigi Brunetti, Giustino Orlando
BACKGROUND: The endocannabinoid (eCB) system plays an important role in regulating emotional disorders, and is involved, directly or indirectly, in psychiatric diseases, such as anxiety and depression. Hemopressin, a hemoglobin α chain-derived peptide, and RVD-hemopressin(α), a N-terminally extended form of hemopressin, act as antagonist/inverse agonist and negative allosteric modulator of the cannabinoid 1 (CB1) receptor, respectively. METHODS: Considering the possible involvement of these peptides on emotional behaviour, the aim of our study was to investigate the behavioural effects of a single intraperitoneal (ip) injection of hemopressin (0...
June 23, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29119914/obsessive-compulsive-disorder-with-comorbid-bipolar-disorders-clinical-features-and-treatment-implications
#4
Federico Mucci, Cristina Toni, Ettore Favaretto, Giulia Vannucchi, Donatella Marazziti, Giulio Perugi
BACKGROUND: Obsessive-compulsive disorder (OCD) symptoms within the context of a bipolar disorder (BD) have been described since the 19th century. Interestingly, the existence of a relevant overlap between the aforementioned psychiatric syndromes has been confirmed by a number of recent epidemiological and family studies. AIMS: The aim of the present paper is to review the clinical features and the therapeutic implications of the OCD-BD comorbidity. DISCUSSION: In the last two decades, the frequent association between OCD and BD has been earning a growing interest given its relevant nosological and therapeutic implications...
November 8, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29110139/the-place-of-antipsychotics-in-the-therapy-of-anxiety-disorders-and-obsessive-compulsive-disorders
#5
REVIEW
Baptiste Pignon, Chloé Tezenas du Montcel, Louise Carton, Antoine Pelissolo
PURPOSE OF REVIEW: The purpose of this review was to assess and present the findings up to this date on the efficacy of antipsychotics in the treatment of generalized anxiety disorders (GAD), social anxiety disorders (SAD), panic disorders (PD), and obsessive-compulsive disorders (OCD), mostly based on published randomized controlled trials (RCTs) or on open-label studies when RCT were lacking. RECENT FINDINGS: Quetiapine could be recommended in patients with GAD...
November 7, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29107895/evaluating-the-protective-effect-of-etazolate-on-memory-impairment-anxiety-and-depression-like-behaviors-induced-by-post-traumatic-stress-disorder
#6
Karem H Alzoubi, Zeinab Y Al Subeh, Omar F Khabour
Post-traumatic stress disorder (PTSD) is a neuropsychiatric disorder that develops after an individual experiences severe life-threatening traumatic stress. Etazolate is a selective phosphodiesterase-4 inhibitor that is specific for cAMP. Etazolate showed anxiolytic and antidepressant activity, and could be useful in managing PTSD co-morbidities. The current study was done to evaluate the role of etazolate in preventing PTSD induced memory impairment, anxiety and depression-like symptoms. PTSD was induced in rats using single prolonged stress model...
November 3, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29105627/macrophage-related-cytokine-expressions-in-depression-mouse-model-induced-by-chronic-unpredictable-mild-stress
#7
Shoulian Zhu, Lejing Li, Ying Li, Wenyuan Cao
Depression is characterized by mental retardation, interest blank, hypoactivity, anxiety, appetite loss, sexual dysfunction, sleep disorders and other symptoms. The incidence of depressed patients has demonstrated an upward trend in recent years. Antidepressant drugs are commonly used in modern medicine, but they have the side effect of drug resistance. This study aims to explore the effect of acupuncture stimulation on expressions of macrophage-related cytokines in mice with depression induced by chronic unpredictable mild stress (CUMS), and to explore the underlying immunological mechanism...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29101244/abrogated-freud-1-cc2d1a-repression-of-5-ht1a-autoreceptors-induces-fluoxetine-resistant-anxiety-depression-like-behavior
#8
Faranak Vahid-Ansari, Mireille Daigle, M Chiara Manzini, Kenji F Tanaka, René Hen, Sean D Geddes, Jean-Claude Béïque, Jonathan James, Zul Merali, Paul R Albert
Freud-1/CC2D1A represses the gene transcription of serotonin-1A (5-HT1A) autoreceptors, which negatively regulate 5-HT tone. To test the role of Freud-1 in vivo, we generated mice with adulthood conditional knockout of Freud-1 in 5-HT neurons (cF1ko). In cF1ko mice, 5-HT1A autoreceptor protein, binding and hypothermia response were increased, with reduced 5-HT content and neuronal activity in the dorsal raphe. The cF1ko mice displayed increased anxiety- and depression-like behavior that was resistant to chronic antidepressant (fluoxetine) treatment...
November 3, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29101052/cluster-analysis-profiling-of-behaviors-in-zebrafish-larvae-treated-with-antidepressants-and-pesticides
#9
Holly Richendrfer, Robbert Creton
Antidepressants are used by a substantial number of women in their childbearing years. Treatment may continue during pregnancy, since untreated depression poses a risk to the mother and child. However, many antidepressants readily pass through the placental barrier to reach the fetus or may be ingested by the newborn via breastmilk. Little is known about the effects of antidepressants on brain development and subsequent behavior in young children. In the current study, we used zebrafish as a model system to examine the neurodevelopmental effects of three commonly prescribed antidepressants, sertraline, duloxetine and bupropion...
October 31, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/29099547/treating-pediatric-anxiety-initial-use-of-ssris-and-other-antianxiety-prescription-medications
#10
Greta A Bushnell, Scott N Compton, Stacie B Dusetzina, Bradley N Gaynes, M Alan Brookhart, John T Walkup, Moira A Rynn, Til Stürmer
OBJECTIVE: Multiple pharmacotherapies for treating anxiety disorders exist, including selective serotonin reuptake inhibitors (SSRIs), the recommended first-line pharmacotherapy for pediatric anxiety. We sought to describe initial antianxiety medication use in children and estimate how long antianxiety medications were continued. METHODS: In a large commercial claims database, we identified children (3-17 years) initiating prescription antianxiety medication from 2004 to 2014 with a recent anxiety diagnosis (ICD-9-CM = 293...
October 31, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29095069/effects-of-tryptophan-depletion-on-selective-serotonin-reuptake-inhibitor-remitted-patients-with-obsessive-compulsive-disorder
#11
Sean D Hood, Annabel Broyd, Hayley Robinson, Jessica Lee, Abdul-Rahman Hudaib, Dana A Hince
BACKGROUND: Serotonergic antidepressants are first-line medication therapies for obsessive-compulsive disorder, however it is not known if synaptic serotonin availability is important for selective serotonin reuptake inhibitor efficacy. The present study tested the hypothesis that temporary reduction in central serotonin transmission, through acute tryptophan depletion, would result in an increase in anxiety in selective serotonin reuptake inhibitor-remitted obsessive-compulsive disorder patients...
October 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29091777/assessment-of-sleep-quality-in-bipolar-euthymic-patients
#12
Necla Keskin, Lut Tamam, Nurgul Ozpoyraz
OBJECTIVE: Sleep quality is affected in bipolar disorder even in euthymic episodes. The aim of this study was to assess sleep quality in bipolar euthymic patients, determine related clinical characteristics and evaluate its effects on functionality. METHODS: A total of 122 outpatients were included. Scales were used to confirm that patients were euthymic. Mini Mental Test was performed to exclude patients with a diagnosis of dementia. A data form for socio-demographic features and clinical characteristics of bipolar disorder have been completed...
September 30, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29091526/hericium-erinaceus-extract-reduces-anxiety-and-depressive-behaviors-by-promoting-hippocampal-neurogenesis-in-the-adult-mouse-brain
#13
Sun Ryu, Hyoun Geun Kim, Joo Youn Kim, Seong Yun Kim, Kyung-Ok Cho
Versatile biological activities of Hericium erinaceus (HE) have been reported in many brain diseases. However, roles of HE in major psychiatric disorders such as depression and anxiety remain to be investigated. Therefore, we evaluated whether HE could reduce anxiety and depressive behaviors in the adult mouse and its underlying mechanisms. Male C57BL/6 mice were administered HE (20 or 60 mg/kg, p.o.) or saline once a day for 4 weeks. Open field and tail suspension tests were performed 30 min after the last administration of HE, followed by forced swim test 2 days later...
November 1, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29082262/vitamin-d-supplementation-improves-mood-in-women-with-type-2-diabetes
#14
Sue Penckofer, Mary Byrn, William Adams, Mary Ann Emanuele, Patricia Mumby, Joanne Kouba, Diane E Wallis
OBJECTIVE: The aim of this study was to determine the effect of vitamin D supplementation on improving mood (depression and anxiety) and health status (mental and physical) in women with type 2 diabetes mellitus (T2DM). METHODS: Fifty women with T2DM and significant depressive symptomology were enrolled into the "Sunshine Study," where weekly vitamin D supplementation (ergocalciferol, 50,000 IU) was given to all participants for six months. The main outcomes included (1) depression (Center for Epidemiologic Studies Depression, CES-D, and Patient Health Questionnaire, PHQ-9), (2) anxiety (State-Trait Anxiety), and (3) health status (Short Form, SF-12)...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29081313/is-trazodone-more-effective-than-clomipramine-in-major-depressed-outpatients-a-single-blind-study-with-intravenous-and-oral-administration
#15
Massimiliano Buoli, Chiara Rovera, Sara Maria Pozzoli, Alessio Fiorentini, Laura Cremaschi, Alice Caldiroli, A Carlo Altamura
OBJECTIVE: Some antidepressants, such as trazodone or clomipramine, can be administered intravenously in patients with major depressive disorder (MDD), with potential benefits compared to the standard oral treatment, but available data about their efficacy are limited. The present study was aimed to compare the effectiveness of trazodone and clomipramine (intravenous [i.v.] followed by oral administration). METHODS: Some 42 patients with a diagnosis of MDD according to the DSM-5 were selected and treated with i...
October 30, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29081307/efficacy-of-vortioxetine-in-working-patients-with-generalized-anxiety-disorder
#16
Michael Cronquist Christensen, Henrik Loft, Ioana Florea, Roger S McIntyre
BACKGROUND: Vortioxetine is an approved antidepressant that has also demonstrated positive effects on anxiety symptoms in subjects with generalized anxiety disorder (GAD). This post-hoc analysis evaluates the efficacy of vortioxetine in GAD subjects who are working and/or pursuing an education. METHODS: In study NCT00744627, 301 GAD subjects were randomized to vortioxetine 5 mg or placebo for 8 weeks. Efficacy measures included the Hamilton Anxiety Rating Scale (HAM-A) total score, response/remission, global functioning (Sheehan Disability Scale [SDS]), and quality of life (Short Form-36 Health Survey)...
October 30, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/29080596/can-cognitive-behavioral-therapy-for-anxiety-and-depression-be-improved-with-pharmacotherapy-a-meta-analysis
#17
REVIEW
David F Tolin
The present meta-analysis examined controlled trials of pharmacologic augmentation of cognitive-behavioral therapy (CBT) for patients with anxiety or depressive disorders. The additive effect of medications was small for both anxiety and depressive disorders at posttreatment, and there was no additive benefit after medications were discontinued. A small body of evidence suggested that antidepressant medications are an efficacious second-line treatment for patients failing to respond to CBT alone. In anxiety disorders, novel agents thought to potentiate the biological mechanisms of CBT showed small effects at posttreatment; after discontinuation, some of these agents were associated with an increasing effect...
December 2017: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29075638/citalopram-ameliorates-impairments-in-spatial-memory-and-synaptic-plasticity-in-female-3xtgad-mice
#18
Zhang Wei, Guo Junhong, Niu Xiaoyuan, Wang Jie, Wang Zhaojun, Wu Meina, Yang Wei, Zhang Jun, Qi Jinshun
Alzheimer's disease (AD) is the primary cause of dementia. There is no effective treatment. Amyloid-β peptide (Aβ) plays an important role in the pathogenesis and thus strategies suppressing Aβ production and accumulation seem promising. Citalopram is an antidepressant drug and can decrease Aβ production and amyloid plaques in transgenic mice of AD and humans. Whether citalopram can ameliorate memory deficit was not known yet. We tested the effects of citalopram on behavioral performance and synaptic plasticity in female 3xTgAD mice, a well-characterized model of AD...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29075577/effects-of-hint1-deficiency-on-emotional-like-behaviors-in-mice-under-chronic-immobilization-stress
#19
Liankang Sun, Peng Liu, Fei Liu, Yuan Zhou, Zheng Chu, Yuqi Li, Guang Chu, Ying Zhang, Jiabei Wang, Yong-Hui Dang
BACKGROUND: Histidine triad nucleotide-binding protein 1 (HINT1) is regarded as a haplo-insufficient tumor suppressor and is closely associated with diverse neuropsychiatric diseases. Moreover, HINT1 is related to gender-specific acute behavior changes in schizophrenia and in response to nicotine. Stress has a range of molecular effects in emotional disorders, which can cause a reduction in brain-derived neurotrophic factor (BDNF) expression in the hippocampus, resulting in hippocampal atrophy and neuronal cell loss...
October 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29073492/tianeptine-is-associated-with-lower-risk-of-suicidal-ideation-worsening-during-the-first-weeks-of-treatment-onset-compared-with-other-antidepressants-a-naturalistic-study
#20
B Nobile, I Jaussent, Ph Gorwood, J Lopez Castroman, E Olié, S Guillaume, Ph Courtet
Worsening of suicidal ideation during the first weeks of antidepressant treatment is a poorly understood phenomenon that prompted regulatory bodies to issue specific warnings. To better understand the causes of this phenomenon, this study compared the risk of suicidal ideation worsening in patients taking different types of antidepressant medications. To this aim, 4017 depressed adult outpatients were followed by general practitioners and psychiatrists throughout France for 6 weeks after prescription of an antidepressant treatment...
October 16, 2017: Journal of Psychiatric Research
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