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https://www.readbyqxmd.com/read/28323624/conventional-or-natural-pharmacotherapy-and-the-prevalence-of-anxiety-and-depression-during-menopause
#1
Dorota Kopciuch, Anna Paczkowska, Tomasz Zaprutko, Michał Michalak, Elżbieta Nowakowska
Context • Psychoneurological symptoms are present in nearly all women in the perimenopausal period. Key elements of care in the period may include hormone replacement therapy (HRT). Alternatively, phytoestrogens, antidepressant pharmacotherapy, or a combination of hormonal and antidepressant therapies may be recommended. Objective • The study intended to verify whether women who are menopausal believe that a reduction in their symptoms of anxiety and depression depends on the type of pharmacotherapy used...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28320023/-update-opipramol
#2
Maximilian Gahr, Christoph Hiemke, Bernhard J Connemann
Opipramol was developed in the 1960s as an antidepressant and has chemical similarities with tricyclic antidepressants. Pharmacodynamic properties with absent reuptake inhibition of serotonin and noradrenaline and agonism at sigma receptors distinguish opipramol from tricyclics. Furthermore, antidepressive effects are smaller than the anxiolytic ones. The mechanism of action of opipramol is currently not sufficiently understood. Agonistic effects at sigma receptors have been linked with therapeutic effects...
March 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28302445/agmatine-attenuates-chronic-unpredictable-mild-stress-induced-anxiety-depression-like-behaviours-and-cognitive-impairment-by-modulating-nitrergic-signalling-pathway
#3
Nitin B Gawali, Vipin D Bulani, Malvika S Gursahani, Padmini S Deshpande, Pankaj S Kothavade, Archana R Juvekar
Agmatine, a neurotransmitter/neuromodulator, has shown to exert numerous effects on the CNS. Chronic stress is a risk factor for development of depression, anxiety and deterioration of cognitive performance. Compelling evidences indicate an involvement of nitric oxide (NO) pathway in these disorders. Hence, investigation of the beneficial effects of agmatine on chronic unpredictable mild stress (CUMS)-induced depression, anxiety and cognitive performance with the involvement of nitrergic pathway was undertaken...
March 13, 2017: Brain Research
https://www.readbyqxmd.com/read/28293470/hypothalamic-pituitary-adrenal-axis-and-depression-symptom-effects-of-an-arginine-vasopressin-type-1b-receptor-antagonist-in-a-one-week-randomized-phase-1b-trial
#4
David A Katz, Charles Locke, Nicholas Greco, Wei Liu, Katherine A Tracy
BACKGROUND: Arginine vasopressin 1B receptor (V1B) antagonists may have utility for the treatment of major depressive disorder (MDD). METHODS: The V1B antagonist ABT-436 (N = 31) or matching placebo (N = 20) was administered to MDD subjects for 7 days. The main study objectives were to assess the safety and hypothalamic-pituitary-adrenal axis (HPA) effects of ABT-436 in MDD subjects. MDD symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAM-D-17) and the subject-rated Mood and Anxiety Symptom Questionnaire (MASQ)...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28272131/predictors-of-pharmacotherapy-response-in-generalized-anxiety-disorder-a-systematic-review
#5
Rafael Ferreira-Garcia, Marina Mochcovitch, Mariana Costa do Cabo, Antonio Egídio Nardi, Rafael Christophe Freire
BACKGROUND: Pharmacotherapy for generalized anxiety disorder (GAD) may be effective in reducing symptoms in the majority of patients. The study of moderators and predictors of treatment response may help clinicians both to select appropriate interventions to maximize the probability of response and to inform the general prognosis. METHODS: A systematic literature search of electronic databases, selected authors, and reference lists was used to identify articles that reported trials of drug monotherapy in GAD...
March 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28267211/retrospective-review-of-serotonergic-medication-tolerability-in-patients-with-neuroendocrine-tumors-with-biochemically-proven-carcinoid-syndrome
#6
Diana D Shi, David P Yuppa, Trevor Dutton, Lauren K Brais, Sarah L Minden, Ilana M Braun, Matthew H Kulke, Jennifer A Chan, Fremonta L Meyer
BACKGROUND: Patients with carcinoid tumors frequently could benefit from the pharmacologic treatment of depression and anxiety. However, many prescribers avoid serotonergic medications due to the theoretical risk of exacerbating carcinoid syndrome. METHODS: The authors conducted a retrospective chart review of patients with carcinoid tumors and elevated serotonin levels (as measured by 24-hour urine 5-hydroxyindoleacetic acid [5-HIAA]) at Dana-Farber/Brigham and Women's Cancer Center who initiated treatment with serotonergic antidepressants after a carcinoid diagnosis from 2003 to 2016...
March 7, 2017: Cancer
https://www.readbyqxmd.com/read/28267046/antidepressants-in-inflammatory-bowel-disease-a-systematic-review
#7
Benjamin J D Macer, Stephanie L Prady, Antonina Mikocka-Walus
BACKGROUND: Antidepressants are commonly used to treat symptoms of anxiety and depression in inflammatory bowel disease (IBD). Recent studies suggest a link between IBD activity and an individual's emotional state which raises the possibility that antidepressants may potentially modify the disease course of IBD. This systematic review thus primarily aims to evaluate the efficacy of antidepressants on IBD activity, and secondarily, on anxiety and depression. METHODS: MEDLINE, EMBASE, Cochrane (IBD Group), CINAHL, AMED, PsycINFO, and OpenGrey were searched from 1990 onward with no restrictions on study design...
April 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28264149/hippocampal-%C3%AE-7-nicotinic-acetylcholine-receptors-contribute-to-modulation-of-depression-like-behavior-in-c57bl-6%C3%A2-j-mice
#8
Yann S Mineur, Tenna N Mose, Sam Blakeman, Marina R Picciotto
BACKGROUND AND PURPOSE: Clinical studies have identified links between cholinergic signaling and depression in human subjects. Increased cholinergic signaling in hippocampus also increases behaviors related to anxiety and depression in mice, which can be reversed by acetylcholine receptor antagonists. EXPERIMENTAL APPROACH: Since the α7 subunit of the nicotinic acetylcholine receptor (nAChR) is highly expressed in hippocampus, we determined whether blocking α7 nAChRs could reverse effects of increased ACh signaling in anxiety- and depression-related behaviors in mice...
March 6, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28259723/influence-of-single-dose-quetiapine-on-fear-network-activity-a-pharmaco-imaging-study
#9
J Diemer, P Zwanzger, I Fohrbeck, M Zavorotnyy, S Notzon, K Silling, V Arolt, K Domschke, B Pfleiderer
OBJECTIVE: Anxiety disorders are among the most frequent psychiatric disorders. Current treatment guidelines recommend antidepressants, the calcium modulator gabapentin, and benzodiazepines as pharmacological treatments. However, delayed onset of action precludes the use of antidepressants as an acute treatment, while benzodiazepines can be recommended only as an emergency treatment due to their inherent risk of dependence. Therefore, an alternative pharmacological agent with acute efficacy is needed...
March 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28259544/deep-brain-stimulation-to-the-medial-forebrain-bundle-for-depression-long-term-outcomes-and-a-novel-data-analysis-strategy
#10
Bettina H Bewernick, Sarah Kayser, Sabrina M Gippert, Christina Switala, Volker A Coenen, Thomas E Schlaepfer
BACKGROUND: Deep brain stimulation (DBS) of the supero-lateral branch of the medial forebrain bundle (slMFB) in treatment-resistant depression (TRD) is associated with acute antidepressant effects. OBJECTIVE: Long-term clinical effects including changes in quality of life, side effects and cognition as well as long-term data covering four years are assessed. METHODS: Eight TRD patients were treated with DBS bilateral to the slMFB. Primary outcome measure was a 50% reduction in Montgomery-Åsberg Depression Rating Scale (MADRS) (response) and remission (MADRS <10) at 12 months compared to baseline...
February 9, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28257284/pharmacogenomics-and-tailored-polypharmacy-an-80-year-old-lady-with-rosuvastatin-associated-rhabdomyolysis-and-maprotiline-related-ogilvie-s-syndrome%C3%A2
#11
Katherina B Sreter, Blazenka Barisic, Sanja Popovic-Grle
What is known and objectives: Multiple adverse drug reactions (ADRs) are expected, and thus should be prevented in the elderly comorbid patient on polypharmacy. Rosuvastatin is commonly prescribed for the treatment and prevention of atherosclerotic diseases, and in rare cases, is associated with rhabdomyolysis. Maprotiline is a tetracyclic antidepressant, infrequently used in the United States, but seemingly more broadly in European countries. Acute colonic pseudo-obstruction (Ogilvie's syndrome) caused by maprotiline has thus far, to our knowledge, not yet been described in the literature...
March 3, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28256473/antidepressant-anxiolytic-activities-of-n-pyridin-3-yl-quinoxalin-2-carboxamide-a-novel-serotonin-type-3-receptor-antagonist-in-behavioural-animal-models
#12
Dilip Kumar Pandey, Thangraj Devadoss, Neha Modak, Radhakrishnan Mahesh
BACKGROUND & OBJECTIVES: Alteration in the serotonin leads to the psychological illness, such as depression, anxiety, schizophrenia, eating disorders, obsessive-compulsive disorder, panic disorders and migraines. The objective of the current study was to investigate the antidepressant and anxiolytic activities of N-(pyridin-3-yl) quinoxalin-2-carboxamide (QCF-21), a novel 5-HT3receptor antagonist in preclinical models of depression and anxiety. METHODS: Antidepressant activity was evaluated in preliminary tests such as forced swim and tail suspension tests (FST & TST)...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28254098/effect-of-manual-acupuncture-stimulation-at-bai-hui-gv-20-or-yint%C3%A3-ng-ex-hn3-on-depressed-rats
#13
Ken Takagi, Nobuyuki Tanahashi, Nozomi Amagasu, Kaito Mizuno, Jun Kawanokuchi, Guo Yi, Torao Ishida
A previous study on rats showed that simultaneous acupuncture stimulation at the "Bai-Hui" (GV 20) and the "Yintáng" (Ex-HN3) acupoints alleviated the state of depression to an extent similar to that achieved by pharmacotherapy. This study investigated whether the alleviation of the depressed state required simultaneous acupuncture at these two acupuncture points. For the purposes of testing the effect of acupuncture on depressive symptoms, we treated a depression model rat, where depression had been induced by using a mild water-immersion stress technique, with either acupuncture stimulation at only one acupuncture point (GV 20 or Ex-HN3) or an antidepressant, and we measured the immobile time for evaluating the state of depression...
January 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28253735/antidepressant-efficacy-for-depression-in-children-and-adolescents-industry-and-nimh-funded-studies
#14
John T Walkup
Significant controversy surrounds the efficacy of the newer antidepressants for children and adolescents with depression. The controversy largely hinges on meta-analyses of studies that suggest that antidepressants are minimally effective, not effective, or equivalent to placebo. In this review, the author discusses several scientific and clinical complexities that are important to understand in reviewing the antidepressant literature: the strengths and weaknesses of meta-analyses; the scientific and regulatory context for the large number of antidepressant trials in the late 1990s and early 2000s; and the distinction between a negative trial, where the treatment does not demonstrate efficacy, and a failed trial, where methodological problems make it impossible to draw any conclusion about efficacy...
March 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28249290/the-association-between-depression-perceived-health-status-and-quality-of-life-among-individuals-with-chronic-kidney-disease-an-analysis-of-the-national-health-and-nutrition-examination-survey-2011-2012
#15
Hoang Anh Nguyen, Cheryl A M Anderson, Cynthia M Miracle, Dena E Rifkin
BACKGROUND: Depression is the most common mental health disorder among those with end-stage renal disease (ESRD), with prevalence of 15-40%. However, the association between chronic kidney disease (CKD) and depression is more variable. We examined the associations of CKD with depression, perceived health status, and quality of life in the National Health and Nutrition Examination Survey (NHANES) 2011-2012. METHODS: This study included 4,075 adults. Depression was defined as a condition when a Patient Health Questionnaire score was ≥10, or when there was reported antidepressant use...
March 2, 2017: Nephron
https://www.readbyqxmd.com/read/28249076/a-consensus-statement-on-the-use-of-ketamine-in-the-treatment-of-mood-disorders
#16
Gerard Sanacora, Mark A Frye, William McDonald, Sanjay J Mathew, Mason S Turner, Alan F Schatzberg, Paul Summergrad, Charles B Nemeroff
Importance: Several studies now provide evidence of ketamine hydrochloride's ability to produce rapid and robust antidepressant effects in patients with mood and anxiety disorders that were previously resistant to treatment. Despite the relatively small sample sizes, lack of longer-term data on efficacy, and limited data on safety provided by these studies, they have led to increased use of ketamine as an off-label treatment for mood and other psychiatric disorders. Observations: This review and consensus statement provides a general overview of the data on the use of ketamine for the treatment of mood disorders and highlights the limitations of the existing knowledge...
March 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28245976/ghrelin-alleviates-anxiety-and-depression-like-behaviors-induced-by-chronic-unpredictable-mild-stress-in-rodents
#17
Hui-Jie Huang, Xiao-Cang Zhu, Qiu-Qin Han, Ya-Lin Wang, Na Yue, Jing Wang, Rui Yu, Bing Li, Gen-Cheng Wu, Qiong Liu, Jin Yu
As a regulator of food intake, ghrelin also plays a key role in mood disorders. Previous studies reported that acute ghrelin administration defends against depressive symptoms of chronic stress. However, the effects of long-term ghrelin on rodents under chronic stress hasn't been revealed. In this study, we found chronic peripheral administration of ghrelin (5nmol/kg/day for 2 weeks, i.p.) could alleviate anxiety- and depression-like behaviors induced by chronic unpredictable mild stress (CUMS). The depression-like behaviors were assessed by the forced swimming test (FST), and anxiety-like behaviors were assessed by the open field test (OFT) and the elevated plus maze test (EPM)...
February 27, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28243610/pet-imaging-of-neurogenic-activity-in-the-adult-brain-toward-in-vivo-imaging-of-human-neurogenesis
#18
Yasuhisa Tamura, Yosky Kataoka
Neural stem cells are present in 2 neurogenic regions, the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG), and continue to generate new neurons throughout life. Adult hippocampal neurogenesis is linked to a variety of psychiatric disorders such as depression and anxiety, and to the therapeutic effects of antidepressants, as well as learning and memory. In vivo imaging for hippocampal neurogenic activity may be used to diagnose psychiatric disorders and evaluate the therapeutic efficacy of antidepressants...
2017: Neurogenesis (Austin, Tex.)
https://www.readbyqxmd.com/read/28242013/targeting-the-microbiota-gut-brain-axis-prebiotics-have-anxiolytic-and-antidepressant-like-effects-and-reverse-the-impact-of-chronic-stress-in-mice
#19
Aurelijus Burokas, Silvia Arboleya, Rachel D Moloney, Veronica L Peterson, Kiera Murphy, Gerard Clarke, Catherine Stanton, Timothy G Dinan, John F Cryan
BACKGROUND: The realization that the microbiota-gut-brain axis plays a critical role in health and disease, including neuropsychiatric disorders, is rapidly advancing. Nurturing a beneficial gut microbiome with prebiotics, such as fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS), is an appealing but underinvestigated microbiota manipulation. Here we tested whether chronic prebiotic treatment modifies behavior across domains relevant to anxiety, depression, cognition, stress response, and social behavior...
February 24, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28239408/the-effects-of-probiotics-on-depressive-symptoms-in-humans-a-systematic-review
#20
REVIEW
Caroline J K Wallace, Roumen Milev
BACKGROUND: Patients suffering from depression experience significant mood, anxiety, and cognitive symptoms. Currently, most antidepressants work by altering neurotransmitter activity in the brain to improve these symptoms. However, in the last decade, research has revealed an extensive bidirectional communication network between the gastrointestinal tract and the central nervous system, referred to as the "gut-brain axis." Advances in this field have linked psychiatric disorders to changes in the microbiome, making it a potential target for novel antidepressant treatments...
2017: Annals of General Psychiatry
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