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https://www.readbyqxmd.com/read/28229112/chronic-psychosocial-stressors-in-adulthood-studies-in-mice-rats-and-tree-shrews
#1
REVIEW
Christopher R Pryce, Eberhard Fuchs
Human psychological stress is the major environmental risk factor for major depression and certain of the anxiety disorders. Psychological stressors often occur in the context of the adult social environment, and they or the memory formed of them impact on the individual across an extended period, thereby constituting chronic psychosocial stress (CPS). Psychosocial stressors often involve loss to the individual, such as the ending of a social relationship or the onset of interpersonal conflict leading to loss of social control and predictability...
February 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/28225710/chronic-stress-exacerbates-neuropathic-pain-via-the-integration-of-stress-affect-related-information-with-nociceptive-information-in-the-central-nucleus-of-the-amygdala
#2
Ming-Jia Li, Ling-Yu Liu, Lin Chen, Jie Cai, You Wan, Guo-Gang Xing
Exacerbation of pain by chronic stress and co-morbidity of pain with stress-related psychiatric disorders including anxiety and depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether chronic forced swim (FS) stress-induced exacerbation of neuropathic pain is mediated by the integration of stress-affect related information with nociceptive information in the central nucleus of the amygdala (CeA). We first demonstrated that chronic FS stress (CFSS) indeed produces both depressive-like behaviors and exacerbation of spared nerve injury (SNI)-induced mechanical allodynia in rats...
December 29, 2016: Pain
https://www.readbyqxmd.com/read/28213105/anxiolytic-and-antidepressant-like-effects-of-an-aqueous-extract-of-tanacetum-parthenium-l-schultz-bip-asteraceae-in-mice
#3
Jorge Cárdenas, Valeria Reyes-Pérez, María Dolores Hernández-Navarro, Ana María Dorantes-Barrón, Salvador Almazán, Rosa Estrada-Reyes
AIM: Tanacetum parthenium L. Schultz-Bip (Asteraceae) is widely used worldwide in traditional medicine for the treatment of convulsions and culture-bound syndromes such as susto (fear). The aim of this work was to evaluate the anxiolytic- and antidepressant-like effects of an aqueous extract of T. parthenium in behavioral paradigms in mice. The effects of T. parthenium were compared with those produced by anxiolytic and antidepressant drugs. We carried out the chemical characterization of the main constituents of T...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28197332/escitalopram-induced-amenorrhea-and-false-positive-urine-pregnancy-test
#4
Vithyalakshmi Selvaraj, Siv Hour, Palanikumar Gunasekar, Caron Gray, James F Smith
Escitalopram is a selective serotonin reuptake inhibitor antidepressant approved by the Food and Drug Administration for the treatment of major depressive disorder and generalized anxiety disorder. A 34-year-old female patient with major depressive disorder developed amenorrhea and had a false-positive urine pregnancy test after initiation of escitalopram treatment. To our knowledge, no published case report of amenorrhea and false-positive urine pregnancy tests in women taking escitalopram exists. This case report suggests that women of child-bearing age should be carefully monitored for amenorrhea while they are on an antidepressant treatment regimen...
January 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/28192737/a-systematic-review-of-yoga-for-major-depressive-disorder
#5
REVIEW
Holger Cramer, Dennis Anheyer, Romy Lauche, Gustav Dobos
BACKGROUND: The purpose of this review was to investigate the efficacy and safety of yoga interventions in treating patients with major depressive disorder. METHODS: MEDLINE, Scopus, and the Cochrane Library were screened through December 2016. Randomized controlled trials (RCTs) comparing yoga to inactive or active comparators in patients with major depressive disorder were eligible. Primary outcomes included remission rates and severity of depression. Anxiety and adverse events were secondary outcomes...
February 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28189098/telmisartan-attenuates-diabetes-induced-depression-in-rats
#6
Urmila Aswar, Shilpa Chepurwar, Sumit Shintre, Manoj Aswar
BACKGROUND: Role of brain renin angiotensin system (RAS) is well understood and various clinical studies have proposed neuroprotective effects of ARB's. It is also assumed that diabetic depression is associated with activation of brain RAS, HPA axis dysregulation and brain inflammatory events. Therefore, the present study was designed to investigate the antidepressant effect of low dose telmisartan (TMS) in diabetes induced depression (DID) in rats. METHODS: Diabetes was induced by injecting streptozotocin...
December 9, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28174136/p-p-methoxyl-diphenyl-diselenide-elicits-an-antidepressant-like-effect-in-mice-without-discontinuation-anxiety-phenotype
#7
Carla Elena Sartori Oliveira, Marcel Henrique Marcondes Sari, Vanessa Angonesi Zborowski, Paulo Cesar Oliveira Araujo, Cristina Wayne Nogueira, Gilson Zeni
Major depressive disorder is the most severe and debilitating disease among psychiatric illnesses. The abrupt interruption of antidepressant treatment may lead to a complex physiological and neuropsychiatric syndrome. The organoselenium compound (MeOPhSe)2 has been reported to have neuroprotective properties in animal models. The study aimed to investigate the effects of single or repeated administration of (MeOPhSe)2 on depressive-like behavior and if the compound administration, and its discontinuation, may affect the anxiolytic-like phenotype in Swiss mice...
February 5, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28173780/protocol-for-the-encode-trial-evaluating-a-novel-online-depression-intervention-for-persons-with-epilepsy
#8
Björn Meyer, Mario Weiss, Martin Holtkamp, Stephan Arnold, Katja Brückner, Johanna Schröder, Franziska Scheibe, Yvonne Nestoriuc
BACKGROUND: Depression is common among persons with epilepsy (PwE), affecting roughly one in three individuals, and its presence is associated with personal suffering, impaired quality of life, and worse prognosis. Despite the availability of effective treatments, depression is often overlooked and treated inadequately in PwE, in part because of assumed concerns over drug interactions or proconvulsant effects of antidepressants. Internet-administered psychological interventions might complement antidepressant medication or psychotherapy, and preliminary evidence suggests that they can be effective...
February 7, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28167853/curcumin-alters-neural-plasticity-and-viability-of-intact-hippocampal-circuits-and-attenuates-behavioral-despair-and-cox-2-expression-in-chronically-stressed-rats
#9
Ga-Young Choi, Hyun-Bum Kim, Eun-Sang Hwang, Seok Lee, Min-Ji Kim, Ji-Young Choi, Sung-Ok Lee, Sang-Seong Kim, Ji-Ho Park
Curcumin is a major diarylheptanoid component of Curcuma longa with traditional usage for anxiety and depression. It has been known for the anti-inflammatory, antistress, and neurotropic effects. Here we examined curcumin effect in neural plasticity and cell viability. 60-channel multielectrode array was applied on organotypic hippocampal slice cultures (OHSCs) to monitor the effect of 10 μM curcumin in long-term depression (LTD) through low-frequency stimulation (LFS) to the Schaffer collaterals and commissural pathways...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28166686/antidepressant-and-anxiolytic-activity-of-lavandula-officinalis-aerial-parts-hydroalcoholic-extract-in-scopolamine-treated-rats
#10
Batool Rahmati, Zahra Kiasalari, Mehrdad Roghani, Mohsen Khalili, Fariba Ansari
CONTEXT: Anxiety and depression are common in Alzheimer's disease (AD). Despite some evidence, it is difficult to confirm Lavandula officinalis Chaix ex Vill (Lamiaceae) as an anxiolytic and antidepressant drug. OBJECTIVE: The effects of L. officinalis extract were studied in scopolamine-induced memory impairment, anxiety and depression-like behaviour. MATERIALS AND METHODS: Male NMRI rats were divided into control, scopolamine alone-treated group received scopolamine (0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28161196/activation-of-cannabinoid-receptors-elicits-antidepressant-like-effects-in-a-mouse-model-of-social-isolation-stress
#11
Arvin Haj-Mirzaian, Hossein Amini-Khoei, Arya Haj-Mirzaian, Shayan Amiri, Maria Ghesmati, Mazyar Zahir, Hamed Shafaroodi, Ahmad Reza Dehpour
Social isolation stress (SIS) paradigm is a chronic stress procedure able to induce profound behavioral and neurochemical changes in rodents and evokes depressive and anxiety-like behaviors. Recent studies demonstrated that the cannabinoid system plays a key role in behavioral abnormalities such as depression through different pathways; however, there is no evidence showing a relation between SIS and the cannabinoid system. This study investigated the role of the cannabinoid system in depressive-like behavior and anxiety-like behavior of IC animals...
February 1, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28149320/antidepressive-response-of-inpatients-with-major-depression-to-adjuvant-occupational-therapy-a-case-control-study
#12
Marc-Andreas Edel, Brian Blackwell, Markus Schaub, Barbara Emons, Tanja Fox, Friederike Tornau, Bernward Vieten, Patrik Roser, Ida Sibylle Haussleiter, Georg Juckel
BACKGROUND: Despite marked costs and limited evidence regarding effectiveness, occupational therapy (OT) is widely applied in psychiatric settings and financed by health insurance companies in European countries. This pilot study investigated the antidepressive effects of adjuvant OT for patients with major depression in a 6-week inpatient setting, stratified for females and males. METHODS: A total of 114 inpatients with major depression were assigned to either a standard OT group (using basic handcraft) or an active control group that played board games (2 h daily, 5 days a week)...
2017: Annals of General Psychiatry
https://www.readbyqxmd.com/read/28146001/clinical-use-of-mood-stabilizers-with-antidepressants-in-asia-report-from-the-research-on-asian-psychotropic-prescription-patterns-for-antidepressants-reap-ad-projects-in-2004-and-2013
#13
Kamini Rajaratnam, Yu-Tao Xiang, Adarsh Tripathi, Helen F K Chiu, Tian-Mei Si, Kok-Yoon Chee, Ajit Avasthi, Sandeep Grover, Mian-Yoon Chong, Hironori Kuga, Shigenobu Kanba, Yan-Ling He, Min-Soo Lee, Shu-Yu Yang, Pichet Udomratn, Roy A Kallivayalil, Andi J Tanra, Margarita M Maramis, Winston W Shen, Norman Sartorius, Ee-Heok Kua, Chay-Hoon Tan, Rathi Mahendran, Naotaka Shinfuku, Min Yi Sum, Ross J Baldessarini, Kang Sim
OBJECTIVE: As most reports concerning treatment with combinations of mood stabilizer (MS) with antidepressant (AD) drugs are based in the West, we surveyed characteristics of such cotreatment in 42 sites caring for the mentally ill in 10 Asian countries. METHODS: This cross-sectional, pharmacoepidemiologic study used 2004 and 2013 data from the REAP-AD (Research Study on Asian Psychotropic Prescription Patterns for Antidepressants) to evaluate the rates and doses of MSs given with ADs and associated factors in 4164 psychiatric patients, using standard bivariate methods followed by multivariable logistic regression modeling...
January 31, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28144887/phytochemical-screening-acute-toxicity-anxiolytic-and-antidepressant-activities-of-the-nelumbo-nucifera-fruit
#14
Muhammad Ali Rajput, Rafeeq Alam Khan
Recently use of herbal therapies and diet rich in flavonoids and vitamin C have increased significantly to treat minor to modest anxiety disorders and various forms of depression. But further research and studies are necessary to evaluate the pharmacological & toxicological effects of plants. Hence present study was designed to conduct phytochemical screening, acute toxicity study, anxiolytic and antidepressant activities of the ethanol extract of Nelumbo nucifera fruit in order to ascertain its therapeutic potential...
February 1, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28144146/evaluation-of-the-risk-factors-of-depressive-disorders-comorbid-with-obstructive-sleep-apnea
#15
Liqiang Cai, Luoyi Xu, Lili Wei, Yi Sun, Wei Chen
OBJECTIVE: Overlap of obstructive sleep apnea (OSA) complicates diagnosis of depressive disorder and renders antidepressant treatment challenging. Previous studies have reported that the incidence of OSA is higher in patients with depression than in the general population. The purpose of this article was to investigate clinical risk factors to predict OSA in depression disorders. METHODS: A total of 115 patients diagnosed with major depressive disorder (MDD) and bipolar disorder (in a major depressive episode), who underwent overnight polysomnography, were studied retrospectively...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28138107/measurement-based-treatment-of-residual-symptoms-using-clinically-useful-depression-outcome-scale-korean-validation-study
#16
Sang Won Jeon, Changsu Han, Young-Hoon Ko, Seo Young Yoon, Chi-Un Pae, Joonho Choi, Yong Chon Park, Jong-Woo Kim, Ho-Kyoung Yoon, Seung-Duk Ko, Ashwin A Patkar, Mark Zimmerman
Objective: This study was aimed at evaluating the diagnostic validity of the Korean version of the Clinically Useful Depression Outcome Scale (CUDOS) with varying follow-up in a typical clinical setting in multiple centers. Methods: In total, 891 psychiatric outpatients were enrolled at the time of their intake appointment. Current diagnostic characteristics were examined using the Structured Clinical Interview for DSM-IV (41% major depressive disorder). The CUDOS was measured and compared with three clinician rating scales and four self-report scales...
February 28, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28137660/effects-of-moderate-treadmill-exercise-and-fluoxetine-on-behavioural-and-cognitive-deficits-hypothalamic-pituitary-adrenal-axis-dysfunction-and-alternations-in-hippocampal-bdnf-and-mrna-expression-of-apoptosis-related-proteins-in-a-rat-model-of-post-traumatic
#17
Sakineh Shafia, Abbas Ali Vafaei, Seyed Afshin Samaei, Ahmad Reza Bandegi, Alireza Rafiei, Reza Valadan, Zahra Hosseini-Khah, Raziyeh Mohammadkhani, Ali Rashidy-Pour
Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need for the development of new treatment. Physical activity is known to improve symptoms of certain neuropsychiatric disorders. The present study investigated the effects of moderate treadmill exercise, the antidepressant fluoxetine and the combined treatment on behavioural deficits, and hypothalamic-pituitary-adrenal (HPA) axis dysfunction...
January 28, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28135884/intranasal-administration-of-dopamine-attenuates-unconditioned-fear-in-that-it-reduces-restraint-induced-ultrasound-vocalizations-and-escape-from-bright-light
#18
Teddy Talbot, Claudia Mattern, Maria Angelica de Souza Silva, Marcus Lira Brandão
BACKGROUND: Although substantial evidence suggests that dopamine (DA) enhances conditioned fear responses, few studies have examined the role of DA in unconditioned fear states. Whereas DA does not cross the blood-brain barrier, intranasally-applied dopamine reaches the brain directly via the nose-brain pathways in rodents, providing an alternative means of targeting DA receptors. Intranasal dopamine (IN-DA) has been demonstrated to bind to DA transporters and to increase extracellular DA in the striatum as well as having memory-promoting effects in rats...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28135595/genetic-background-contributes-to-the-co-morbidity-of-anxiety-and-depression-with-audiogenic-seizure-propensity-and-responses-to-fluoxetine-treatment
#19
Karine Yu Sarkisova, Irina B Fedotova, Natalia M Surina, Georgy M Nikolaev, Olga V Perepelkina, Zoya A Kostina, Inga I Poletaeva
BACKGROUND: Anxiety and depression are the most frequent comorbidities of different types of convulsive and non-convulsive epilepsies. Increased anxiety and depression-like phenotype have been described in the genetic absence epilepsy models as well as in models of limbic epilepsy and acquired seizure models, suggesting a neurobiological connection. However, whether anxiety and/or depression are comorbid to audiogenic epilepsy remains unclear. The aim of this study was to investigate whether anxiety or depression-like behavior can be found in rat strains with different susceptibility to audiogenic seizures (AS) and whether chronic fluoxetine treatment affects this co-morbidity...
January 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28133901/association-of-peripartum-synthetic-oxytocin-administration-and-depressive-and-anxiety-disorders-within-the-first-postpartum-year
#20
Aimee R Kroll-Desrosiers, Benjamin C Nephew, Jessica A Babb, Yurima Guilarte-Walker, Tiffany A Moore Simas, Kristina M Deligiannidis
BACKGROUND: Due to its potent effects on social behavior, including maternal behavior, oxytocin has been identified as a potential mediator of postpartum depression and anxiety. The objective of this study was to examine the relationship between peripartum synthetic oxytocin administration and the development of depressive and anxiety disorders within the first year postpartum. We hypothesized that women exposed to peripartum synthetic oxytocin would have a reduced risk of postpartum depressive and anxiety disorders compared with those without any exposure...
February 2017: Depression and Anxiety
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