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https://www.readbyqxmd.com/read/26075081/inhibiting-the-progression-of-arterial-calcification-with-vitamin-k-in-hemodialysis-patients-ipack-hd-trial-rationale-and-study-design-for-a-randomized-trial-of-vitamin-k-in-patients-with-end-stage-kidney-disease
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Rachel M Holden, Sarah L Booth, Andrew G Day, Catherine M Clase, Deborah Zimmerman, Louise Moist, M Kyla Shea, Kristin M McCabe, Sophie A Jamal, Sheldon Tobe, Jordan Weinstein, Rao Madhumathi, Michael A Adams, Daren K Heyland
BACKGROUND: Cardiovascular disease, which is due in part to progressive vascular calcification, is the leading cause of death among patients with end stage kidney disease (ESKD) on dialysis. A role for vitamin K in the prevention of vascular calcification is plausible based on the presence of vitamin K dependent proteins in vascular tissue, including matrix gla protein (MGP). Evidence from animal models and observational studies support a role for vitamin K in the prevention of vascular calcification...
2015: Canadian Journal of Kidney Health and Disease
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