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https://www.readbyqxmd.com/read/28633381/robust-tests-for-additive-gene-environment-interaction-in-case-control-studies-using-gene-environment-independence
#1
Gang Liu, Seunggeun Lee, Alice W Lee, Anna H Wu, Elisa V Bandera, Allan Jensen, Mary Anne Rossing, Kirsten B Moysich, Jenny Chang-Claude, Jennifer Doherty, Aleksandra Gentry-Maharaj, Lambertus Kiemeney, Simon A Gayther, Francesmary Modugno, Leon Massuger, Ellen L Goode, Brooke Fridley, Kathryn L Terry, Daniel W Cramer, Susan J Ramus, Hoda Anton-Culver, Argyrios Ziogas, Jonathan P Tyrer, Joellen M Schildkraut, Susanne K Kjaer, Penelope M Webb, Roberta B Ness, Usha Menon, Andrew Berchuck, Paul D Pharoah, Harvey Risch, Celeste Leigh Pearce, Bhramar Mukherjee
There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure. Using gene-environment independence enhances the power for testing multiplicative interaction in case-control studies. However, under departure from this assumption, substantial bias in the estimates and inflated Type I error in the corresponding tests can occur. This paper extends the empirical Bayes (EB) approach previously developed for multiplicative interaction that trades off between bias and efficiency in a data-adaptive way, to the additive scale...
June 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28633054/men-and-women-with-psychosis-and-the-impact-of-illness-duration-on-sex-differences-the-second-australian-national-survey-of-psychosis
#2
Mary-Claire Hanlon, Linda E Campbell, Natalie Single, Clare Coleman, Vera A Morgan, Susan M Cotton, Helen J Stain, David J Castle
We aimed to examine and compare sex-differences in people receiving treatment for psychotic illnesses in community settings, based on long or short duration of illness; expecting association between longer illness-duration and worse outcomes in women and men. Clinical, demographic and service-use data from the Survey of High Impact Psychosis were analysed by sex and duration of illness (≤5 years; ≥6 years), using independent t-tests, chi-square tests, one-way ANOVA, and Cramer's V. Of the 1825 participants, 47% had schizophrenia, 17...
June 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28632688/high-quality-3-dimensional-1h-magnetic-resonance-spectroscopic-imaging-of-the-prostate-without-endorectal-receive-coil-using-a-semi-laser-sequence
#3
Nassim Tayari, Isabell K Steinseifer, Kirsten M Selnæs, Tone F Bathen, Marnix C Maas, Arend Heerschap
OBJECTIVES: Inclusion of 3-dimensional H magnetic resonance spectroscopic imaging (3D-H-MRSI) in routine multiparametric MRI of the prostate requires good quality spectra and easy interpretable metabolite maps of the whole organ obtained without endorectal coil in clinically feasible acquisition times. We evaluated if a semi-LASER pulse sequence with gradient offset independent adiabaticity refocusing pulses (GOIA-sLASER) for volume selection can meet these requirements. MATERIALS AND METHODS: Thirteen patients with suspicion of prostate cancer and 1 patient known to have prostate cancer were examined at 3 T with a multichannel body-receive coil...
June 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28632514/childhood-precursors-of-the-narcissistic-personality
#4
Phebe Cramer
This research identifies the childhood personality characteristics that predict the presence of narcissism in adulthood. Using data from the longitudinal study of Block and Block (The California Child Q-set. Palo Alto, CA: Consulting Psychologists Press, 1980), childhood personality characteristics were assessed at age 11 (N = 100) using the California Child Q-set. A number of these were shown to differentially predict the presence of grandiose or vulnerable narcissism at age 23. Factor analyses of the Child Q-set items showed that the presence of Grandiose Narcissism was positively related to childhood factors representing social presence and negatively related to planfulness...
June 19, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28629625/what-exactly-regression-of-atherosclerosis-or-foreign-body-reaction-with-hyaline-arteriosclerosis-drives-transient-scaffolding-of-coronary-arteries-a-pooled-analysis-of-observational-absorb-studies-with-a-serial-multimodality-imaging-substudy-of-absorb-cohort
#5
Alexander N Kharlamov, John A Feinstein, John A Cramer, John A Boothroyd
OBJECTIVES: We aimed to estimate the trends of the artery remodeling after transient scaffolding. BACKGROUND: At least 2.62% reduction of the per cent atheroma volume (PAV) or plaque burden (PB) performed in ABSORB B trial at 60months. METHODS: The detailed multiple serial imaging evaluation was performed by intravascular ultrasound (IVUS) in comparison with quantitative coronary angiography (QCA), multislice CT (MSCT) and optical coherence tomography (OCT) thru 24months in the ABSORB cohort B1 trial (n=45) with the pooled analysis in ABSORB A and B trials (n=131)...
June 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28628592/genetic-variation-and-neuroplasticity-role-in-rehabilitation-after-stroke
#6
Jill Campbell Stewart, Steven C Cramer
BACKGROUND AND PURPOSE: In many neurologic diagnoses, significant interindividual variability exists in the outcomes of rehabilitation. One factor that may impact response to rehabilitation interventions is genetic variation. Genetic variation refers to the presence of differences in the DNA sequence among individuals in a population. Genetic polymorphisms are variations that occur relatively commonly and, while not disease-causing, can impact the function of biological systems. The purpose of this article is to describe genetic polymorphisms that may impact neuroplasticity, motor learning, and recovery after stroke...
July 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/28627086/the-hypertension-of-hemophilia-is-associated-with-vascular-remodeling-in-the-joint
#7
Richard Fw Barnes, Thomas J Cramer, Tudor H Hughes, Annette von Drygalski
OBJECTIVE: Hemophilic arthropathy is associated with pronounced vascular joint remodeling. Also, compared to the general population, PWH have a higher prevalence of hypertension not explained by usual risk factors. Since vascular remodeling in various vascular beds is a hallmark of hypertension, we hypothesized that vascular joint remodeling is associated with elevated blood pressures and hypertension. METHODS: Elbows, knees and ankles of 28 adult PWH were evaluated for vascular abnormalities with MSKUS/PD, as well as for radiographic and clinical status and pain...
June 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28624975/deleterious-acute-and-chronic-effects-of-bradycardic-right-ventricular-apex-pacing-consequences-for-arrhythmic-outcome
#8
T R G Stams, A Dunnink, W M van Everdingen, H D M Beekman, R van der Nagel, B Kok, M F A Bierhuizen, M J Cramer, M Meine, M A Vos
In the chronic complete atrioventricular (AV) block dog (CAVB) model, both bradycardia and altered ventricular activation due to the uncontrolled idioventricular rhythm contribute to ventricular remodeling and the enhanced susceptibility to Torsade de Pointes (TdP) arrhythmias. We investigated the effect of permanent bradycardic right ventricular apex (RVA) pacing on mechanical and electrical remodeling and TdP. In 23 anesthetized dogs, serial experiments were performed at sinus rhythm (SR), acutely after AV block (AAVB) and 3 weeks of remodeling CAVB at a fixed pacing rate of 60/min...
July 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28621065/editorial-yoga-for-qol-in-ulcerative-colitis-any-better-than-other-supportive-activities-authors-reply
#9
EDITORIAL
H Cramer, G Dobos, J Langhorst
No abstract text is available yet for this article.
July 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28619299/comparative-cost-analysis-of-inpatient-integrative-medicine-results-of-a-pilot-study
#10
Thomas Ostermann, Romy Lauche, Holger Cramer, Gustav Dobos
BACKGROUND: Costs of integrative treatment alone and in comparison with other treatment approaches have scarcely been reported in the past. This study presents results of a comparative cost analysis of an inpatient integrative medicine treatment costs. METHODS: Data from 2006 for inpatients referred to a Department of Integrative Medicine in Germany were used. Case-related treatment costs were calculated, and transformed into Casemix-Indices and revenues per DRG...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28616711/integrating-noe-and-rdc-using-sum-of-squares-relaxation-for-protein-structure-determination
#11
Y Khoo, A Singer, D Cowburn
We revisit the problem of protein structure determination from geometrical restraints from NMR, using convex optimization. It is well-known that the NP-hard distance geometry problem of determining atomic positions from pairwise distance restraints can be relaxed into a convex semidefinite program (SDP). However, often the NOE distance restraints are too imprecise and sparse for accurate structure determination. Residual dipolar coupling (RDC) measurements provide additional geometric information on the angles between atom-pair directions and axes of the principal-axis-frame...
June 14, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28613861/methane-oxidation-to-methanol-catalyzed-by-cu-oxo-clusters-stabilized-in-nu-1000-metal-organic-framework
#12
Takaaki Ikuno, Jian Zheng, Aleksei Vjunov, Maricruz Sanchez-Sanchez, Manuel A Ortuño, Dale Pahls, John L Fulton, Donald M Camaioni, Zhanyong Li, Debmalya Ray, B Layla Mehdi, Nigel D Browning, Omar K Farha, Joseph T Hupp, Christopher J Cramer, Laura Gagliardi, Johannes A Lercher
Copper oxide clusters synthesized via atomic layer deposition on the nodes of the metal-organic framework NU-1000 are active for oxidation of methane to methanol under mild reaction conditions. Analysis of chemical reactivity, in situ X-ray absorption spectroscopy, and density functional theory calculations are used to determine structure/activity relations in the Cu-NU-1000 catalytic system. The Cu-loaded MOF contained Cu as clusters of a few atoms each. The Cu was present at ambient conditions as a mixture of ~15 % Cu(+) and ~ 85 % Cu(2+)...
June 14, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28613317/tuning-the-properties-of-metal-organic-framework-nodes-as-supports-of-single-site-iridium-catalysts-node-modification-by-atomic-layer-deposition-of-aluminium
#13
Dong Yang, Mohammad R Momeni, Hakan Demir, Dale R Pahls, Martino Rimoldi, Timothy C Wang, Omar K Farha, Joseph T Hupp, Christopher J Cramer, Bruce C Gates, Laura Gagliardi
The metal-organic framework NU-1000, with Zr6-oxo, hydroxo, and aqua nodes, was modified by incorporation of hydroxylated Al(iii) ions by ALD-like chemistry with [Al(CH3)2(iso-propoxide)]2 followed by steam (ALD = atomic layer deposition). Al ions were installed to the extent of approximately 7 per node. Single-site iridium diethylene complexes were anchored to the nodes of the modified and unmodified MOFs by reaction with Ir(C2H4)2(acac) (acac = acetylacetonate) and converted to Ir(CO)2 complexes by treatment with CO...
June 14, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28611677/greater-neural-adaptations-following-high-vs-low-load-resistance-training
#14
Nathaniel D M Jenkins, Amelia A Miramonti, Ethan C Hill, Cory M Smith, Kristen C Cochrane-Snyman, Terry J Housh, Joel T Cramer
We examined the neuromuscular adaptations following 3 and 6 weeks of 80 vs. 30% one repetition maximum (1RM) resistance training to failure in the leg extensors. Twenty-six men (age = 23.1 ± 4.7 years) were randomly assigned to a high- (80% 1RM; n = 13) or low-load (30% 1RM; n = 13) resistance training group and completed leg extension resistance training to failure 3 times per week for 6 weeks. Testing was completed at baseline, 3, and 6 weeks of training. During each testing session, ultrasound muscle thickness and echo intensity, 1RM strength, maximal voluntary isometric contraction (MVIC) strength, and contractile properties of the quadriceps femoris were measured...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28610802/herbal-medicine-in-children-with-respiratory-tract-infection-systematic-review-and-meta-analysis
#15
REVIEW
Dennis Anheyer, Holger Cramer, Romy Lauche, Felix Joyonto Saha, Gustav Dobos
BACKGROUND: Herbal medicines are particularly regarded as an alternative or complement to conventional pharmaceuticals in the treatment and prevention of respiratory tract infections (RTI). OBJECTIVE: Therefore the purpose of this review was to identify evidence for herbal therapy in the treatment of RTI concerning effectiveness and safety. DATA SOURCES: Medline/PubMed, Scopus and the Cochrane Library were searched through 12 February 2015...
June 10, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28609892/reappraisal-of-i-synagrops-i-g%C3%A3-nther-1887-with-rehabilitation-and-revision-of-i-parascombrops-i-alcock-1889-including-description-of-seven-new-species-and-two-new-genera-perciformes-acropomatidae
#16
Werner W Schwarzhans, Artem M Prokofiev
An ongoing review of the fishes of the basal percoid family Acropomatidae has revealed that the genus Synagrops Günther, 1887 as it is currently understood is not a natural group. Species with a serrated pelvic-fin spine are here placed in the resurrected genus Parascombrops Alcock, 1889 (type-species: Parascombrops pellucidus Alcock, 1889), and the new, monospecific genus Caraibops n. gen. (type-species: Synagrops trispinosus Mochizuki & Sano, 1984). Parascombrops is unique amongst Acropomatidae in the combination of the presence of vacant 8th interneural space, a predorsal formula /0+0/0+2/ and an epaxialis attachment type 1...
May 4, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609330/age-modulates-physiological-responses-during-fan-use-under-extreme-heat-and-humidity
#17
Daniel Gagnon, Steven A Romero, Matthew N Cramer, Ken Kouda, Paula Ys Poh, Hai Ngo, Ollie Jay, Craig G Crandall
PURPOSE: We examined the effect of electric fan use on cardiovascular and thermoregulatory responses of nine young (26 ± 3 years) and nine aged (68 ± 4 years) adults exposed to extreme heat and humidity. METHODS: While resting at a temperature of 42°C, relative humidity increased from 30 to 70% in 2% increments every 5 minutes. On randomized days, the protocol was repeated without or with fan use. Heart rate (HR), core (Tcore) and mean skin (Tsk) temperatures were measured continuously...
June 12, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28608327/diffusional-kurtosis-imaging-dki-incorporation-into-an-intravoxel-incoherent-motion-ivim-mr-model-to-measure-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-in-healthy-subjects
#18
Aude Pavilla, Giulio Gambarota, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Hervé Saint-Jalmes
OBJECTIVES: The objectives were to investigate the diffusional kurtosis imaging (DKI) incorporation into the intravoxel incoherent motion (IVIM) model for measurements of cerebral hypoperfusion in healthy subjects. MATERIALS AND METHODS: Eight healthy subjects underwent a hyperventilation challenge with a 4-min diffusion weighted imaging protocol, using 8 b values chosen with the Cramer-Rao Lower Bound optimization approach. Four regions of interest in gray matter (GM) were analyzed with the DKI-IVIM model and the bi-exponential IVIM model, for normoventilation and hyperventilation conditions...
June 12, 2017: Magma
https://www.readbyqxmd.com/read/28607648/the-treatment-of-vesicoureteral-reflux-in-children-by-endoscopic-sub-mucosal-intra-ureteral-injection-of-dextranomer-hyaluronic-acid-a-case-series-multi-centre-study
#19
Osama Bawazir
BACKGROUND: Vesicoureteral reflux is a risk factor for progressive renal damage. In addition to long-term antibiotic prophylaxis and open surgical re-implantation, endoscopic sub-mucosal intra-ureteral injection of implant material is a therapeutic alternative that gained a world-wide preference. OBJECTIVE: The aim of this study was to determine the effectiveness and safety of the implant material, dextranomer/hyaluronic acid, in a cohort of Saudi children with vesicoureteral reflux...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28602499/susceptibility-weighted-angiography-and-diffusion-weighted-imaging-in-posterior-reversible-encephalopathy-syndrome-is-there-an-association-between-hemorrhage-cytotoxic-edema-blood-pressure-and-imaging-severity
#20
Shivaprakash Basavanthaiah Hiremath, Amol Anantrao Gautam, Shilpa Anil, Reji Thomas, Geena Benjamin
PURPOSE: To assess the significance of association and possible correlation between hemorrhage, cytotoxic edema, blood pressure and imaging severity in posterior reversible encephalopathy syndrome (PRES). MATERIALS AND METHODS: This retrospective study included the medical and imaging records of 35 consecutive patients with PRES. The clinical data analysis included the highest recorded blood pressure (BP) on the day of the ictus, MRI including spin-echo echo planar diffusion-weighted imaging (DWI), susceptibility weighted angiography (SWAN) and conventional sequences...
June 8, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
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