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https://www.readbyqxmd.com/read/28728850/decline-in-risk-of-recurrent-cardiovascular-events-in-the-period-1996-to-2014-partly-explained-by-better-treatment-of-risk-factors-and-less-subclinical-atherosclerosis
#1
Gijs F N Berkelmans, Yolanda van der Graaf, Jannick A N Dorresteijn, Gert Jan de Borst, Maarten J Cramer, L Jaap Kappelle, Jan Westerink, Frank L J Visseren
BACKGROUND: To quantify the decline in recurrent major cardiovascular events (MCVE) risk in patients with clinically manifest vascular disease between 1996 and 2014 and to assess whether the improvements in recurrent MCVE-risk can be explained by reduced prevalence of risk factors, more medication use and less subclinical atherosclerosis. METHODS AND RESULTS: The study was conducted in the Second Manifestations of ARTerial disease (SMART) cohort in patients entering the cohort in the period 1996-2014...
July 14, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28727225/intact-blood-brain-barrier-during-spontaneous-attacks-of-migraine-without-aura-a-3t-dce-mri-study
#2
F M Amin, A Hougaard, S P Cramer, C E Christensen, F Wolfram, H B W Larsson, M Ashina
BACKGROUND AND PURPOSE: The integrity of the blood-brain barrier (BBB) has been questioned in migraine, but BBB permeability has never been investigated during spontaneous migraine attacks. In the present study, BBB permeability during spontaneous attacks of migraine without aura was investigated compared to an interictal state. METHODS: Seventy-four patients suffering from migraine without aura were recruited to participate in this cross-sectional dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) study...
July 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28727137/national-evaluation-of-multidisciplinary-quality-metrics-for-head-and-neck-cancer
#3
John D Cramer, Sedona E Speedy, Robert L Ferris, Alfred W Rademaker, Urjeet A Patel, Sandeep Samant
BACKGROUND: The National Quality Forum has endorsed quality-improvement measures for multiple cancer types that are being developed into actionable tools to improve cancer care. No nationally endorsed quality metrics currently exist for head and neck cancer. METHODS: The authors identified patients with surgically treated, invasive, head and neck squamous cell carcinoma in the National Cancer Data Base from 2004 to 2014 and compared the rate of adherence to 5 different quality metrics and whether compliance with these quality metrics impacted overall survival...
July 20, 2017: Cancer
https://www.readbyqxmd.com/read/28723684/validation-of-an-instrument-to-measure-patients-intentions-and-ability-to-change-attitudes-and-behavior
#4
Arndt Büssing, Désirée Poier, Romy Lauche, Gustav Dobos, Holger Cramer
No abstract text is available yet for this article.
July 20, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28715304/influence-of-stretching-velocity-on-musculotendinous-stiffness-of-the-hamstrings-during-passive-straight-leg-raise-assessments
#5
Ty B Palmer, Nathaniel D M Jenkins, Brennan J Thompson, Joel T Cramer
BACKGROUND: Recently, passive musculotendinous stiffness (MTS) has been assessed manually in the field; however, when conducting these types of assessments, the stretching velocity must be controlled to avoid eliciting the stretch reflex, which can be observed by increased electromyographic (EMG) amplitude of the stretched muscles and greater resistive torque (indicating the assessment is no longer passive). OBJECTIVE: To examine the effects of slow, medium, and fast stretching velocities during manually-applied passive straight-leg raise (SLR) assessments on hamstrings MTS and EMG amplitude characteristics...
August 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28708726/measuring-cerebral-hypoperfusion-induced-by-hyperventilation-challenge-with-intravoxel-incoherent-motion-magnetic-resonance-imaging-in-healthy-volunteers
#6
Aude Pavilla, Alessandro Arrigo, Mehdi Mejdoubi, Régis Duvauferrier, Giulio Gambarota, Hervé Saint-Jalmes
OBJECTIVES: The aim of this study was to demonstrate the feasibility to assess cerebral hypoperfusion with a hyperventilation (HV) challenge protocol using intravoxel incoherent motion (IVIM) magnetic resonance imaging. MATERIALS AND METHODS: Magnetic resonance imaging experiments were performed on 10 healthy volunteers at 1.5 T, with a diffusion IVIM magnetic resonance imaging protocol using a set of b-values optimized by Cramer-Rao Lower Bound analysis. Hypoperfusion was induced by an HV maneuver...
July 13, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28708549/effects-of-image-quality-on-the-fundamental-limits-of-image-registration-accuracy
#7
Michael D Ketcha, Tharindu De Silva, Runze Han, Ali Uneri, Joseph Goerres, Matthew Jacobson, Sebastian Vogt, Gerhard Kleinszig, Jeffrey H Siewerdsen
For image-guided procedures, the imaging task is often tied to the registration of intraoperative and preoperative images to a common coordinate system. While the accuracy of this registration is a vital factor in system performance, there is relatively little work that relates registration accuracy to image quality factors such as dose, noise, and spatial resolution. To create a theoretical model for such a relationship, we present a Fisher information approach to analyze registration performance in explicit dependence on the underlying image quality factors of image noise, spatial resolution, and signal power spectrum...
July 11, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28708025/chlamydia-and-gonorrhea-screening-and-expedited-partner-therapy-ept-practices-of-college-student-health-centers
#8
Sara B Oswalt, Heather P Eastman-Mueller
OBJECTIVE: To examine college student health centers' practices related to STD screening and treatment over a five-year period. PARTICIPANTS: College student health centers (SHCs) that completed the ACHA Pap and STI Survey between 2010 and 2014. METHODS: Chi-square tests were conducted with Cramer's V providing a measure of association. RESULTS: Chlamydia screening of women under 25 years of age was a well-established practice...
July 14, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28706998/the-extended-erlang-truncated-exponential-distribution-properties-and-application-to-rainfall-data
#9
I E Okorie, A C Akpanta, J Ohakwe, D C Chikezie
The Erlang-Truncated Exponential ETE distribution is modified and the new lifetime distribution is called the Extended Erlang-Truncated Exponential EETE distribution. Some statistical and reliability properties of the new distribution are given and the method of maximum likelihood estimate was proposed for estimating the model parameters. The usefulness and flexibility of the EETE distribution was illustrated with an uncensored data set and its fit was compared with that of the ETE and three other three-parameter distributions...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28705027/tensor-algebra-based-geometric-methodology-to-codify-central-chirality-on-organic-molecules
#10
C R García-Jacas, Y Marrero-Ponce, T Hernández-Ortega, K Martinez-Mayorga, L Cabrera-Leyva, J C Ledesma-Romero, I Aguilera-Fernández, A R Rodríguez-León
A novel mathematical procedure to codify chiral features of organic molecules in the QuBiLS-MIDAS framework is introduced. This procedure constitutes a generalization to that commonly used to date, where the values 1 and -1 (correction factor) are employed to weight the molecular vectors when each atom is labelled as R (rectus) or S (sinister) according to the Cahn-Ingold-Prelog rules. Therefore, values in the range [Formula: see text] with steps equal to 0.25 may be accounted for. The atoms labelled R or S can have negative and positive values assigned (e...
July 14, 2017: SAR and QSAR in Environmental Research
https://www.readbyqxmd.com/read/28699766/assessing-acute-psychological-distress-in-the-immediate-aftermath-of-stroke
#11
Vanessa Juth, Michelle K Chan, Steven C Cramer, E Alison Holman
BACKGROUND AND PURPOSE: High acute stress may presage the development of subsequent cardiovascular ailments. Understanding how best to assess acute stress may inform early interventions seeking to prevent long-term morbidity/mortality following stroke. A mixed methods approach examined early post-stroke acute stress symptoms using the post-traumatic stress disorder checklist-5 (PCL-5) and the acute stress disorder scale (ASDS). METHODS: A focus group of stroke survivors and/or their caregivers ( N=8) evaluated PCL-5/ASDS feasibility, and 20 patients hospitalized for acute stroke were interviewed 2-10 days post-stroke onset, using either the PCL-5 or the ASDS...
July 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28697711/biomarkers-of-stroke-recovery-consensus-based-core-recommendations-from-the-stroke-recovery-and-rehabilitation-roundtable
#12
Lara A Boyd, Kathryn S Hayward, Nick S Ward, Cathy M Stinear, Charlotte Rosso, Rebecca J Fisher, Alexandre R Carter, Alex P Leff, David A Copland, Leeanne M Carey, Leonardo G Cohen, D Michele Basso, Jane M Maguire, Steven C Cramer
The most difficult clinical questions in stroke rehabilitation are "What is this patient's potential for recovery?" and "What is the best rehabilitation strategy for this person, given her/his clinical profile?" Without answers to these questions, clinicians struggle to make decisions regarding the content and focus of therapy, and researchers design studies that inadvertently mix participants who have a high likelihood of responding with those who do not. Developing and implementing biomarkers that distinguish patient subgroups will help address these issues and unravel the factors important to the recovery process...
July 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28697708/agreed-definitions-and-a-shared-vision-for-new-standards-in-stroke-recovery-research-the-stroke-recovery-and-rehabilitation-roundtable-taskforce
#13
Julie Bernhardt, Kathryn S Hayward, Gert Kwakkel, Nick S Ward, Steven L Wolf, Karen Borschmann, John W Krakauer, Lara A Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer
The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery research. Common language and definitions were required to develop an agreed framework spanning the four working groups: translation of basic science, biomarkers of stroke recovery, measurement in clinical trials and intervention development and reporting. This paper outlines the working definitions established by our group and an agreed vision for accelerating progress in stroke recovery research...
July 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28696712/bridging-zirconia-nodes-within-a-metal-organic-framework-via-catalytic-ni-hydroxo-clusters-to-form-hetero-bimetallic-nanowires
#14
Ana E Platero-Prats, Aaron B League, Varinia Bernales, Jingyun Ye, Leighanne C Gallington, Aleksei Vjunov, Neil M Schweitzer, Zhanyong Li, Jian Zheng, B Layla Mehdi, Andrew J Stevens, Alice Dohnalkova, Mahalingam Balasubramanian, Omar K Farha, Joseph T Hupp, Nigel D Browning, John L Fulton, Donald M Camaioni, Johannes A Lercher, Donald G Truhlar, Laura Gagliardi, Christopher J Cramer, Karena W Chapman
Metal-organic frameworks (MOFs), with their well-ordered pore networks and tunable surface chemistries, offer a versatile platform for preparing well-defined nanostructures wherein functionality such as catalysis can be incorporated. Notably, atomic layer deposition (ALD) in MOFs has recently emerged as a versatile approach to functionalize MOF surfaces with a wide variety of catalytic metal-oxo species. Understanding the structure of newly deposited species and how they are tethered within the MOF is critical to understanding how these components couple to govern the active material properties...
July 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28696673/how-nothing-boosts-affinity-hydrophobic-ligand-binding-to-the-virtually-vacated-s1-pocket-of-thermolysin
#15
Stefan G Krimmer, Jonathan Cramer, Johannes Schiebel, Andreas Heine, Gerhard Klebe
We investigated the hydration state of the deep, well accessible hydrophobic S1' specificity pocket of the metalloprotease thermolysin with purposefully designed ligands using high-resolution crystallography and isothermal titration calorimetry. The S1' pocket is known to recognize selectively a very stringent set of aliphatic side chains such as valine, leucine and isoleucine of putative substrates. We engineered a weak-binding ligand covering the active site of the protease without addressing the S1' pocket, thus transforming it into an enclosed cavity...
July 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28696574/divergent-asymmetric-synthesis-of-polycyclic-compounds-via-vinyl-triazenes
#16
Kay Severin, David Kossler, Florian Perrin, Abdusalom Suleymanov, Gregor Kiefer, Rosario Scopelliti, Nicolai Cramer
Vinyl triazenes are obtained by enantioselective [2+2] cycloaddition reactions of bicyclic alkenes with 1-alkynyltriazenes in the presence of a RuII-catalyst with a chiral cyclopentadienyl ligand. The triazenes serve as unique vinyl cation surrogates. Under acidic conditions, the triazene functionality can be replaced by a variety of groups including halides, alkoxides, sulfoxides, amides, arenes and heteroarenes, providing efficient access to a pool of chiral polycyclic compounds.
July 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28695357/primary-lower-limb-lymphoedema-classification-with-non-contrast-mr-lymphography
#17
Lionel Arrivé, S Derhy, B Dahan, S El Mouhadi, L Monnier-Cholley, Y Menu, C Becker
PURPOSE: The purpose of the present study was to analyse the performance of non-contrast MR lymphography for the classification of primary lower limb lymphoedema in 121 consecutive patients with 187 primary lower limb lymphoedemas. MATERIALS AND METHODS: 121 consecutive patients with clinically diagnosed primary lower limb lymphoedema underwent non-contrast MR lymphography with a free-breathing 3D fast spin-echo sequence with a very long TR/TE (4000/884 ms). MR examinations were retrospectively reviewed for severity of lymphoedema (absent, mild, moderate, severe) and characteristics of inguinal lymph nodes and iliac and inguinal lymphatic trunks graded as aplasic (no lymph nodes or lymphatic trunks), hypoplasic (less lymph nodes or lymphatic trunks), normal and hyperplasic (more lymph nodes or more and/or dilated trunks)...
July 10, 2017: European Radiology
https://www.readbyqxmd.com/read/28689610/characteristics-of-americans-choosing-vegetarian-and-vegan-diets-for-health-reasons
#18
Holger Cramer, Christian S Kessler, Tobias Sundberg, Matthew J Leach, Dania Schumann, Jon Adams, Romy Lauche
OBJECTIVE: Examine the prevalence, patterns, and associated factors of using a vegetarian or vegan diet for health reasons in the US general population. DESIGN: Cross-sectional data from the 2012 National Health Interview Survey. PARTICIPANTS: Nationally representative sample (N = 34,525). VARIABLES MEASURED: Prevalence of ever use and 12-month use of vegetarian or vegan diet for health reasons, patterns of use, and sociodemographic and health-related factor associated with use...
July 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28689580/a-molecular-modeling-based-method-to-predict-elution-behavior-and-binding-patches-of-proteins-in-multimodal-chromatography
#19
Suvrajit Banerjee, Siddharth Parimal, Steven M Cramer
Multimodal (MM) chromatography provides a powerful means to enhance the selectivity of protein separations by taking advantage of multiple weak interactions that include electrostatic, hydrophobic and van der Waals interactions. In order to increase our understanding of such phenomena, a computationally efficient approach was developed that combines short molecular dynamics simulations and continuum solvent based coarse-grained free energy calculations in order to study the binding of proteins to Self Assembled Monolayers (SAM) presenting MM ligands...
June 23, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28687574/successful-treatment-of-recurrent-primitive-myxoid-mesenchymal-tumor-of-infancy-with-bcor-internal-tandem-duplication
#20
Stuart L Cramer, Rong Li, Siraj Ali, Julie A Bradley, Hee K Kim, Joseph G Pressey
Primitive myxoid mesenchymal tumor of infancy (PMMTI) is a rare tumor with <20 cases reported to date. Recently PMMTI tumors have been found to harbor BCOR internal tandem duplication (ITD), the same genetic alteration detected in clear cell sarcoma of the kidney (CCSK). Complete surgical resection of PMMTI is often curative, but no standard of care has been established for unresectable tumors. We describe a female patient who presented at 13 months of age with a paraspinal mass and spinal cord compression...
July 2017: Journal of the National Comprehensive Cancer Network: JNCCN
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