keyword
MENU ▼
Read by QxMD icon Read
search

cramer

keyword
https://www.readbyqxmd.com/read/29792819/distinct-mechanisms-of-transcription-initiation-by-rna-polymerases-i-and-ii
#1
Christoph Engel, Simon Neyer, Patrick Cramer
RNA polymerases I and II (Pol I and Pol II) are the eukaryotic enzymes that catalyze DNA-dependent synthesis of ribosomal RNA and messenger RNA, respectively. Recent work shows that the transcribing forms of both enzymes are similar and the fundamental mechanisms of RNA chain elongation are conserved. However, the mechanisms of transcription initiation and its regulation differ between Pol I and Pol II. Recent structural studies of Pol I complexes with transcription initiation factors provided insights into how the polymerase recognizes its specific promoter DNA, how it may open DNA, and how initiation may be regulated...
May 20, 2018: Annual Review of Biophysics
https://www.readbyqxmd.com/read/29784233/using-baseline-data-to-predict-chronic-ptsd-48-months-after-mothers-report-intimate-partner-violence-outcomes-for-mothers-and-the-intergenerational-impact-on-child-behavioral-functioning
#2
John Maddoux, Judith McFarlane, Lene Symes, Nina Fredland, Gene Feder
Worldwide one in three women report intimate partner violence. Many of these women report long term mental health problems, especially PTSD, which is associated with negative problem solving, isolation, somatization, depression, and anxiety. Children are impacted by their exposure to domestic violence and experience internal (i.e., depression, anxiety) and external (i.e., hostility, delinquency) behavioral clinical problems. To predict which women will experience chronic PTSD symptoms, a PTSD predictor tool was developed and applied to PTSD symptom scores four years after 300 mothers with children (age 18 months to 16 years) received assistance for the violence...
June 2018: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/29778948/bioisosteres-of-ethyl-8-ethynyl-6-pyridin-2-yl-4h-benzo-f-imidazo-1-5-a-1-4-diazepine-3-carboxylate-hz-166-as-novel-alpha-2-3-selective-potentiators-of-gaba-a-receptors-improved-bioavailability-enhances-anticonvulsant-efficacy
#3
J M Witkin, J L Smith, X Ping, S D Gleason, M M Poe, G Li, X Jin, J Hobbs, J M Schkeryantz, J S McDermott, A I Alatorre, J N Siemian, J W Cramer, D C Airey, K R Methuku, V V N P B Tiruveedhula, T M Jones, J Crawford, M J Krambis, J L Fisher, J M Cook, R Cerne
HZ-166 has previously been characterized as an α2,3-selective GABAA receptor modulator with anticonvulsant, anxiolytic, and anti-nociceptive properties but reduced motor effects. We discovered a series of ester bioisosteres with reduced metabolic liabilities, leading to improved efficacy as anxiolytic-like compounds in rats. In the present study, we evaluated the anticonvulsant effects KRM-II-81 across several rodent models. In some models we also evaluated key structural analogs. KRM-II-81 suppressed hyper-excitation in a network of cultured cortical neurons without affecting the basal neuronal activity...
May 3, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29777938/austrian-firearm-legislation-and-its-effects-on-suicide-and-homicide-mortality-a-natural-quasi-experiment-amidst-the-global-economic-crisis
#4
Daniel König, Patrick Swoboda, Robert J Cramer, Christoph Krall, Vita Postuvan, Nestor D Kapusta
BACKGROUND: Restriction of access to suicide methods has been shown to effectively reduce suicide mortality rates. AIMS: To examine how the global economic crisis of 2008 and the firearm legislation reform of 1997 affected suicide and homicide mortality rate within Austria. METHODS: Official data for the years 1985-2016 for firearm certificates, suicide, homicide, unemployment rates and alcohol consumption were examined using auto regressive error and Poisson regression models...
May 16, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29774742/dual-role-of-water-in-heterogeneous-catalytic-hydrolysis-of-sarin-by-zirconium-based-metal-organic-frameworks
#5
Mohammad R Momeni, Christopher J Cramer
Recent experimental studies on ZrIV-based metal-organic frameworks (MOFs) have shown the extraordinary effective-ness of these porous materials for the detoxification of phos-phorus-based chemical warfare agents (CWAs). However, pressing challenges remain with respect to characterizing these catalytic processes both at the molecular and crystalline lev-els. We here use theory to compare the reactivity of different zirconium-based MOFs for the catalytic hydrolysis of the CWA sarin, using both periodic and cluster modeling...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29773892/metabolite-cycled-density-weighted-concentric-rings-k-space-trajectory-dw-crt-enables-high-resolution-1-h-magnetic-resonance-spectroscopic-imaging-at-3-tesla
#6
Adam Steel, Mark Chiew, Peter Jezzard, Natalie L Voets, Puneet Plaha, Michael Albert Thomas, Charlotte J Stagg, Uzay E Emir
Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times and artifacts caused by subject motion and hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling in combination with semi-LASER excitation and metabolite-cycling enables high-resolution MRSI data to be rapidly acquired at 3 Tesla...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762136/evaluation-of-a-clinical-tof-pet-detector-design-that-achieves-%C3%A2-100-ps-coincidence-time-resolution
#7
Joshua W Cates, Craig S Levin
Commercially available clinical positron emission tomography (PET) detectors employ scintillation crystals that are long (20 mm length) and narrow (4-5 mm width) optically coupled on their narrow end to a photosensor. The aspect ratio of this traditional crystal rod conguration and 511 keV photon attenuation properties yield signicant variances in scintillation light collection efficiency and transit time to the photodetector, due to variations in the 511 keV photon interaction depth in the crystal. These variances contribute significantly to coincidence time resolution degradation...
May 15, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29761698/assessment-of-compressive-raman-versus-hyperspectral-raman-for-microcalcification-chemical-imaging
#8
Camille Scotté, Hilton B de Aguiar, Didier Marguet, Ellen Marie Green, Pascaline Bouzy, Sébastien Vergnole, Charles Peter Winlove, Nicholas Stone, Herve Rigneault
We experimentally implement a compressive Raman technology (CRT) that incorporates chemometric analysis directly into the spectrometer hardware by means of a digital micromirror device (DMD). The DMD is a programmable optical filter on which optimized binary filters are displayed. The latter are generated with an algorithm based on the Cramer-Rao lower bound. We com-pared the developed CRT microspectrometer with two conventional state-of-the-art Raman hyperspectral imaging systems on samples mimicking microcalcifications relevant for breast cancer diagnosis...
May 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29759782/regional-left-ventricular-electrical-activation-and-peak-contraction-are-closely-related-in-candidates-for-cardiac-resynchronization-therapy
#9
Masih Mafi-Rad, Jetske Van't Sant, Yuri Blaauw, Pieter A Doevendans, Maarten J Cramer, Harry J Crijns, Frits W Prinzen, Mathias Meine, Kevin Vernooy
OBJECTIVES: This study determined the relationship between the timing of left ventricular (LV) electrical activation and peak contraction at potential LV pacing locations in candidates for cardiac resynchronization therapy (CRT). BACKGROUND: Targeting the LV lead to the region of latest electrical activation or the segment of latest peak contraction has both been shown to improve CRT response. Whether these regions correspond within CRT patients is uncertain. METHODS: Twenty-eight consecutive CRT candidates underwent intraprocedural coronary venous electroanatomic mapping using EnSite NavX...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29756324/prospective-frequency-correction-using-outer-volume-suppression-localized-navigator-for-mr-spectroscopy-and-spectroscopic-imaging
#10
Chu-Yu Lee, In-Young Choi, Phil Lee
PURPOSE: New frequency correction methods are required to achieve the accurate measurement of frequency drifts in MRS and MRSI. We present a prospective frequency correction method with outer volume suppression (OVS)-based localization and selective water excitation for effective frequency correction with better SNR improvement compared to other techniques. METHODS: An OVS-localized navigator was developed to prospectively correct frequency drifts during MRS and MRSI measurements...
May 13, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29748650/how-empathic-are-vegan-medical-professionals-compared-to-others-leads-from-a-paper-pencil-survey
#11
Christian S Kessler, Andreas Michalsen, Sophie Holler, Vijayendra S Murthy, Holger Cramer
The aim of this survey was to examine differences in personality profiles among 198 vegan (n = 64; 32.3%), vegetarian (n = 78; 39.4%) and omnivore (n = 55; 27.8%) medical professionals. Outcomes were motives for the nutritional approaches, WHO QoL-BREF, Big Five SOEP Inventory, Portraits Value Questionnaire, and Empathizing Scale. Regarding motives for particular diets, omnivores rated influence of guardians (p < 0.001), physical health (p = 0.017) and food taste (p = 0.001) as more and love of animals as less important (p < 0...
May 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29746454/notes-from-the-field-diarrhea-and-acute-respiratory-infection-oral-cholera-vaccination-coverage-and-care-seeking-behaviors-of-rohingya-refugees-cox-s-bazar-bangladesh-october-november-2017
#12
Aimee Summers, Alexa Humphreys, Eva Leidman, Leonie Toroitich Van Mil, Caroline Wilkinson, Anuradhha Narayan, Mohammad Lalan Miah, Blanche Greene Cramer, Oleg Bilukha
No abstract text is available yet for this article.
May 11, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29746248/nrvs-for-fe-in-biology-experiment-and-basic-interpretation
#13
Leland B Gee, Hongxin Wang, Stephen P Cramer
For over 20 years, nuclear resonance vibrational spectroscopy (NRVS) has been used to study vibrational dynamics of iron-containing materials. With the only selection rule being iron motion, 57 Fe NRVS has become an excellent tool to study iron-containing enzymes. Over the past decade, considerable progress has been made in the study of complex metalloenzymes using NRVS. Iron cofactors in heme-containing globins; [2Fe2S], [3Fe4S], [4Fe4S] proteins; the [NiFe] and [FeFe] hydrogenases; and nitrogenases have been explored in a fashion not possible through traditional vibrational spectroscopy...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29741426/yoga-therapy-in-the-german-healthcare-system
#14
Holger Cramer
An estimated 15.7 million Germans are currently practicing yoga or are at least interested in starting to practice, and they often perceive yoga as a therapeutic approach. From a healthcare system perspective, the situation is less clear. Here, yoga is only recognized as a recreational or preventive activity. When yoga teachers fulfill specific qualifications, their preventive yoga classes are covered by the statutory health insurances. Only those with additional qualifications in medicine or psychotherapy, however, can independently use and promote "yoga therapy...
May 9, 2018: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/29740743/initial-brain-metastasis-velocity-does-the-rate-at-which-cancers-first-seed-the-brain-affect-outcomes
#15
Michael H Soike, Emory R McTyre, Ryan T Hughes, Michael Farris, Christina K Cramer, Michael C LeCompte, Claire M Lanier, Jimmy Ruiz, Jing Su, Kounosuke Watabe, J Daniel Bourland, Michael T Munley, Stacey O'Neill, Adrian W Laxton, Stephen B Tatter, Michael D Chan
PURPOSE/OBJECTIVE(S): Brain metastasis velocity (BMV) is a metric that describes the rate of development of new brain metastases (BM) after initial stereotactic radiosurgery (SRS). A limitation in the application of BMV is it cannot be applied until time of first BM failure after SRS. We developed initial BM velocity (iBMV), a new metric that accounts for the number of BM at first SRS and the time since initial cancer diagnosis. MATERIALS/METHODS: We reviewed patients with BM treated at our institution with upfront SRS without WBRT...
May 8, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29739303/the-utilization-of-formal-physical-therapy-after-shoulder-arthroplasty
#16
Eric R Wagner, Muriel J Solberg, Laurence D Higgins
Study Design Epidemiological retrospective database study. Background It is widely believed that structured rehabilitation programs by professional therapists help guide patients through the various recovery periods after shoulder arthroplasty, speeding up their recovery and improving their final functional gains. However, to our knowledge, there are no studies providing information about the current state of physical rehabilitation use after shoulder arthroplasty. Objectives Describe the variation in physical rehabilitation utilization after total and reverse total shoulder arthroplasty and identify differences in utilization based on type of insurance (private versus public), gender, age, region of the country, and type of replacement...
May 8, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29738514/direct-position-determination-of-multiple-non-circular-sources-with-a-moving-coprime-array
#17
Yankui Zhang, Bin Ba, Daming Wang, Wei Geng, Haiyun Xu
Direct position determination (DPD) is currently a hot topic in wireless localization research as it is more accurate than traditional two-step positioning. However, current DPD algorithms are all based on uniform arrays, which have an insufficient degree of freedom and limited estimation accuracy. To improve the DPD accuracy, this paper introduces a coprime array to the position model of multiple non-circular sources with a moving array. To maximize the advantages of this coprime array, we reconstruct the covariance matrix by vectorization, apply a spatial smoothing technique, and converge the subspace data from each measuring position to establish the cost function...
May 8, 2018: Sensors
https://www.readbyqxmd.com/read/29733460/sensitivity-regularization-of-the-cram%C3%A3-r-rao-lower-bound-to-minimize-b-1-nonuniformity-effects-in-quantitative-magnetization-transfer-imaging
#18
Mathieu Boudreau, G Bruce Pike
PURPOSE: To develop and validate a regularization approach of optimizing B1 insensitivity of the quantitative magnetization transfer (qMT) pool-size ratio (F). METHODS: An expression describing the impact of B1 inaccuracies on qMT fitting parameters was derived using a sensitivity analysis. To simultaneously optimize for robustness against noise and B1 inaccuracies, the optimization condition was defined as the Cramér-Rao lower bound (CRLB) regularized by the B1 -sensitivity expression for the parameter of interest (F)...
May 7, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29732080/tailored-trisubstituted-chiral-cp-x-rh-iii-catalysts-for-kinetic-resolutions-of-phosphinic-amides
#19
Y Sun, N Cramer
A trisubstituted chiral Cp x ligand family is introduced. Based on the disubstituted atropchiral Cp x ligand scaffold, the introduction of a bulky third substituent at the central position of the Cp ring leads to substantially increased selectivities for rhodium(iii)-catalyzed kinetic resolutions and allowed for s -factors of up to 50. Their superiority is demonstrated by kinetic resolutions of phosphinic amides providing access to compounds with stereogenic phosphorus(v) atoms. The unreacted acyclic phosphinic amide and the cyclized product are both obtained in good yields and enantioselectivities...
March 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29731120/clinical-and-echocardiographic-prevalence-and-detection-of-congenital-and-acquired-cardiac-abnormalities-in-girls-and-women-with-the-turner-syndrome
#20
Anji T Yetman, Lois Starr, Jennifer Sanmann, Megan Wilde, Mary Murray, Jonathan W Cramer
The prevalence of congenital and acquired heart disease in patients with the Turner syndrome (TS) is based on historic cohorts who underwent imaging before the advent of modern day echocardiography. Recent small studies suggest a higher prevalence of cardiac defects. We reviewed clinical and echocardiographic data on 564 girls and women with TS to assess the prevalence of cardiac defects. Echocardiographic review on a subset of this population was performed to assess for diagnostic limitations of echocardiography in assessing for congenital and acquired defects in this patient cohort...
April 17, 2018: American Journal of Cardiology
keyword
keyword
49712
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"