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Jeffrey Cummings, Philip Scheltens, Ian McKeith, Rafael Blesa, John E Harrison, Paulo H F Bertolucci, Kenneth Rockwood, David Wilkinson, Wouter Wijker, David A Bennett, Raj C Shah
BACKGROUND: Souvenaid® (uridine monophosphate, docosahexaenoic acid, eicosapentaenoic acid, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium), was developed to support the formation and function of neuronal membranes. OBJECTIVE: To determine effect sizes observed in clinical trials of Souvenaid and to calculate the number needed to treat to show benefit or harm. METHODS: Data from all three reported randomized controlled trials of Souvenaid in Alzheimer's disease (AD) dementia (Souvenir I, Souvenir II, and S-Connect) and an open-label extension study were included in analyses of effect size for cognitive, functional, and behavioral outcomes...
October 20, 2016: Journal of Alzheimer's Disease: JAD
Vazrick Nazari, B Christian Schmidt, Sean Prosser, Paul D N Hebert
Analysis of the DNA barcode region of the cytochrome c oxidase 1 gene from a specimen of the extinct Jamaican sunset moth, Urania sloanus, places this species as a sister to the Central American U. fulgens. We found that all Urania F. species were closely related (<2.8% maximum divergence at COI), with the Cuban endemic U. boisduvalii appearing as sister to the rest. The low divergence in DNA barcodes and genitalic structures indicate that the Cuban U. poeyi and eastern Brazilian U. brasiliensis are geographic segregates of U...
2016: PloS One
Roberto Hegg, André Mattar, João Nunes de Matos-Neto, José Luiz Pedrini, Sabina Bandeira Aleixo, Roberto Odebrecht Rocha, Renato Peixoto Cramer-Junior, Sylvie van-Eyll-Rocha
OBJECTIVES: To compare the efficacy and safety of two filgrastim formulations for controlling chemotherapy-induced neutropenia and to evaluate the non-inferiority of the test drug relative to the originator. METHODS: This phase III non-inferiority study had a randomized, multicenter, and open-label design. The patients were randomized at a ratio of 1:1 with a follow-up period of 6 weeks for each patient. In both study arms, filgrastim was administered subcutaneously at a daily dose of 5 mg/kg body weight...
October 1, 2016: Clinics
Mohammad-Ali Yazdani Abyaneh, Peter Engel, Andrzej Slominski, Bruce Ragsdale, Richard Agag, Daniel Cramer, J Andrew Carlson
BACKGROUND: Giant basal cell carcinomas (GBCCs), (BCC ≥ 5 cm), are often painless, destructive tumors resulting from poorly understood patient neglect. OBJECTIVES: To elucidate etiopathogenic factors distinguishing GBCC from basal cell carcinoma (BCC) and identify predictors for disease-specific death (DSD). METHODS: Case-control study examining clinicopathologic and neuroactive factors (β-endorphin, met-enkephalin, serotonin, adrenocorticotropic hormone, and neurofilament expression) in GBCC and BCC...
October 18, 2016: American Journal of Dermatopathology
Jesper Brink Svendsen, Bo Baslund, Elisabeth Præstekjær Cramer, Nicolas Rapin, Niels Borregaard, Jack Bernard Cowland
Jumonji Domain-Containing Protein 3 (JMJD3)/lysine demethylase 6B (KDM6B) is an epigenetic modulator that removes repressive histone marks on genes. Expression of KDM6B mRNA is elevated in leukocytes from patients with ANCA-associated vasculitis (AAV) and has been suggested to be the reason for higher proteinase 3 (PR3) mRNA expression in these cells due to derepression of PRTN3 gene transcription. MicroRNA-941 (miR-941) has been shown to target KDM6B mRNA and inhibit JMJD3 production. We therefore investigated whether polymorphonuclear granulocytes (PMNs) from patients suffering from granulomatosis with polyangiitis (GPA) have lower expression of miR-941 than healthy control donors as a biological cause for higher JMJD3 levels...
2016: PloS One
JiSun Choi, Emily Cramer
OBJECTIVE: The aim of this study was to investigate the perceptions of RNs on the implementation of safe patient handling and mobility (SPHM) programs in states with and without SPHM legislation. BACKGROUND: Despite numerous strategies developed to reduce caregiver injuries, nurses are still experiencing work-related musculoskeletal injuries. A comprehensive SPHM program has been found to be effective in reducing patient handling injuries among nurses. METHODS: By using data from 143 480 RNs working in 321 acute care hospitals in 44 US states, RNs' perceptions on 6 key aspects of SPHM programs were compared between states with and without SPHM legislation and among 11 unit types...
October 12, 2016: Journal of Nursing Administration
Chen-Shan Chin, Paul Peluso, Fritz J Sedlazeck, Maria Nattestad, Gregory T Concepcion, Alicia Clum, Christopher Dunn, Ronan O'Malley, Rosa Figueroa-Balderas, Abraham Morales-Cruz, Grant R Cramer, Massimo Delledonne, Chongyuan Luo, Joseph R Ecker, Dario Cantu, David R Rank, Michael C Schatz
While genome assembly projects have been successful in many haploid and inbred species, the assembly of noninbred or rearranged heterozygous genomes remains a major challenge. To address this challenge, we introduce the open-source FALCON and FALCON-Unzip algorithms ( to assemble long-read sequencing data into highly accurate, contiguous, and correctly phased diploid genomes. We generate new reference sequences for heterozygous samples including an F1 hybrid of Arabidopsis thaliana, the widely cultivated Vitis vinifera cv...
October 17, 2016: Nature Methods
Brandon Cramer, Minzhi Xing, Hyun S Kim
PURPOSE: To determine the effect of Y radioembolization therapy on health-related quality of life (HRQOL) in patients with neuroendocrine tumor liver metastases (NETLM) in a prospective longitudinal study. MATERIALS AND METHODS: Baseline Short-Form 36 HRQOL scores were evaluated for significant change (P < 0.05) within the total patient population at 1, 3, 6, 12, and 24 months following Y using paired t-test. Overall survival (OS) times were calculated from first Y using the Kaplan-Meier method and analyzed using the log-rank test...
October 5, 2016: Clinical Nuclear Medicine
Farid Ahmed Sid, Karim Abed-Meraim, Rachid Harba, Fatima Oulebsir-Boumghar
PURPOSE: To examine the effects of MR acquisition parameters on brain white matter fiber orientation estimation and parameter of clinical interest in crossing fiber areas based on the Multi-Tensor Model (MTM). MATERIAL AND METHODS: We compute the Cramér-Rao Bound (CRB) for the MTM and the parameter of clinical interest such as the Fractional Anisotropy (FA) and the dominant fiber orientations, assuming that the diffusion MRI data are recorded by a multi-coil, multi-shell acquisition system...
October 12, 2016: Magnetic Resonance Imaging
Iva Brabcová, Marie Trešlová, Sylva Bártlová, Jitka Vacková, Valerie Tóthová, Lenka Maťhová
BACKGROUND AND AIM: Nutrition is an important social determinant of health that influences the ageing process. The aim of this study was to evaluate the nutritional condition of a group of seniors and identify the bio-psycho-social factors that increase the risk of malnutrition. METHODS: The research was conducted using a quantitative method. The standardised scales Mini Nutritional Assessment - Short Form (MNA-SF) and the Geriatric depression scale (GDS-5) were used to evaluate the nutritional condition and tendency towards depression of the tested group...
September 2016: Central European Journal of Public Health
Camille Clare, Mary-Beatrice Squire, Karem Alvarez, Julia Meisler, Candice Fraser
OBJECTIVE: The United States has the highest rate of adolescent pregnancy of the industrialized nations. Previously reported patient barriers to the use of contraception included an ambivalence about pregnancy; method side effects; difficulty using methods; lack of satisfaction with methods; concerns about safety; expense; and a lack of knowledge about long-acting reversible contraception (LARC). This survey aims to determine if there are additional barriers to contraception use and adherence among an ethnically diverse urban population...
October 15, 2016: International Journal of Adolescent Medicine and Health
Paula Cramer, Barbara Eichhorst, Hans Christian Reinhardt, Michael Hallek
Given the current dynamics in the development of novel agents for CLL therapy, the task to find optimal, non-toxic combinations has become the primary goal. This article gives an update of the most interesting novel drugs. The strategy of the German CLL Study Group to use these agents in combinations is described in detail, highlighting the strategy and first results of a recently started series of phase II combination trials, the BXX series using agents such as bendamustine, idelalisib, ibrutinib, obinutuzumab, ofatumumab and venetoclax...
March 2016: Best Practice & Research. Clinical Haematology
Alexandra Flynn, Rosalee Zackula, Nicole M Klaus, Liz McGinness, Susan Carr, Matthew Macaluso
OBJECTIVE: Yellow Ribbon is a gatekeeper-type suicide prevention program that is widely used in public schools. However, data on its effectiveness are limited. The purpose of our study was to evaluate self-reported changes in knowledge and comfort level communicating about suicide following Yellow Ribbon training for a large, representative sample of students from a public school system in the midwestern United States. METHODS: The program was administered to students within the same school district during 2006 through 2009...
2016: Primary Care Companion to CNS Disorders
Henrik B W Larsson, Mark B Vestergaard, Ulrich Lindberg, Helle K Iversen, Stig P Cramer
PURPOSE: Capillary transit time heterogeneity, measured as CTH, may set the upper limit for extraction of substances in brain tissue, e.g., oxygen. The purpose of this study was to investigate the feasibility of dynamic contrast-enhanced T1 weighted MRI (DCE-MRI) at 3 Tesla (T), in estimating CTH based on a gamma-variate model of the capillary transit time distribution. In addition, we wanted to investigate if a subtle increase of the blood-brain barrier permeability can be incorporated into the model, still allowing estimation of CTH...
October 12, 2016: Journal of Magnetic Resonance Imaging: JMRI
Anatoly A Tsygankov, Suleyman I Allakhverdiev, Tatsuya Tomo, Govindjee
During June 19-26, 2016, an international conference ( ) on "Photosynthesis Research for Sustainability-2016" was held in honor of Nathan Nelson and Turhan Nejat Veziroğlu at the Institute of Basic Biological Problems, Russian Academy of Sciences, formerly Institute of Photosynthesis, Academy of Sciences of the USSR, Pushchino, Russia. Further, this conference celebrated the 50th anniversary of the Institute. We provide here a brief introduction and key contributions of the two honored scientists, and then information on the conference, on the speakers, and the program...
October 10, 2016: Photosynthesis Research
J A Van Heerden, J R Burger, J J Gerber
BACKGROUND: Prescribing for older patients is a well-recognised problem, and inappropriate items are prescribed frequently. Several tools and criteria are available to promote rational prescribing in older patients. OBJECTIVE: To determine the prevalence of potentially inappropriate prescriptions (PIPs) in older South African patients. METHODS: A retrospective drug utilisation review was conducted using medicine claims data over a 1-year period...
September 9, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Jorin Hoogenboom, Nathalja Berghuis, Dario Cramer, Rene Geurts, Han Zuilhof, Tom Wennekes
BACKGROUND: Carbohydrates, also called glycans, play a crucial but not fully understood role in plant health and development. The non-template driven formation of glycans makes it impossible to image them in vivo with genetically encoded fluorescent tags and related molecular biology approaches. A solution to this problem is the use of tailor-made glycan analogs that are metabolically incorporated by the plant into its glycans. These metabolically incorporated probes can be visualized, but techniques documented so far use toxic copper-catalyzed labeling...
October 10, 2016: BMC Plant Biology
Gopal Nataraj, Jon-Fredrick Nielsen, Jeffrey Fessler
Rapid, reliable quantification of MR relaxation parameters T1 and T2 is desirable for many clinical applications. Steady-state sequences such as Spoiled Gradient-Recalled Echo (SPGR) and Dual-Echo Steady-State (DESS) are fast and wellsuited for relaxometry because the signals they produce are quite sensitive to T1 and T2 variation. However, T1, T2 estimation with these sequences typically requires multiple scans with varied sets of acquisition parameters. This paper describes a systematic framework for selecting scan types (e...
October 4, 2016: IEEE Transactions on Medical Imaging
Merle Hantsche, Patrick Cramer
Transcription is the first step in expression of the genetic information in all living cells. The regulation of transcription underlies cell differentiation, organism development, and responses of living systems to changes in the environment. During transcription, the enzyme RNA polymerase uses DNA as a template to synthesize a complementary RNA copy from a gene. Here we summarize the progress in our understanding of the structural basis of eukaryotic gene transcription that has been made ten years after the Nobel Prize in Chemistry given to Roger Kornberg in 2006...
October 10, 2016: Angewandte Chemie
Amelia A Miramonti, Nathaniel D M Jenkins, Preeti D Oza, Joseph P Weir, Joel T Cramer
INTRODUCTION: This study examined relationships among mechanomyographic (MMG), electromyographic (EMG), and peak twitch torque (PTT) responses as well as test-retest reliability when recorded during recruitment curves in the soleus muscle. METHODS: PTT, EMG (M-wave, H-reflex), and MMG responses were recorded during recruitment curves in 16 subjects (age=24±2y) on 2 separate days. The sum of the M-wave and H-reflex (M+H) was calculated. Correlations among variables and test-retest reliability were determined...
October 8, 2016: Muscle & Nerve
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