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https://www.readbyqxmd.com/read/29346186/fall-rates-in-urban-and-rural-nursing-units-does-location-matter
#1
Marianne Baernholdt, Ivora D Hinton, Guofen Yan, Wenjun Xin, Emily Cramer, Nancy Dunton
Patient falls remain a leading adverse event in hospitals. In a study of 65 rural hospitals with 222 nursing units and 560 urban hospitals with 4274 nursing units, we found that geographic region, unit type, and nurse staffing, education, experience, and outcomes were associated with fall rates. Implications include specific attention to fall prevention in rehabilitation units, creating better work environments that promote nurse retention, and provide RN-BSN educational opportunities.
January 16, 2018: Journal of Nursing Care Quality
https://www.readbyqxmd.com/read/29344631/a-brief-exposure-based-treatment-vs-cognitive-processing-therapy-for-posttraumatic-stress-disorder-a-randomized-noninferiority-clinical-trial
#2
Denise M Sloan, Brian P Marx, Daniel J Lee, Patricia A Resick
Importance: Written exposure therapy (WET), a 5-session intervention, has been shown to efficaciously treat posttraumatic stress disorder (PTSD). However, this treatment has not yet been directly compared with a first-line PTSD treatment such as cognitive processing therapy (CPT). Objective: To determine if WET is noninferior to CPT in patients with PTSD. Design, Setting, and Participants: In this randomized clinical trial conducted at a Veterans Affairs medical facility between February 28, 2013, and November 6, 2016, 126 veteran and nonveteran adults were randomized to either WET or CPT...
January 17, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29342846/mental-health-and-drivers-of-need-in-emergent-and-non-emergent-emergency-department-ed-use-do-living-location-and-non-emergent-care-sources-matter
#3
Moira C McManus, Robert J Cramer, Maureen Boshier, Muge Akpinar-Elci, Bonnie Van Lunen
Emergency department (ED) utilization has increased due to factors such as admissions for mental health conditions, including suicide and self-harm. We investigate direct and moderating influences on non-emergent ED utilization through the Behavioral Model of Health Services Use. Through logistic regression, we examined correlates of ED use via 2014 New York State Department of Health Statewide Planning and Research Cooperative System outpatient data. Consistent with the primary hypothesis, mental health admissions were associated with emergent use across models, with only a slight decrease in effect size in rural living locations...
January 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29342020/editorial-spring-board-gender-composition-in-high-impact-general-surgery-journals-over-20-years
#4
Chelsea A Harris, Tanima Banerjee, Monica Cramer, Shannon Manz, Sarah T Ward, Justin Dimick, Dana A Telem
OBJECTIVE: To quantify gender composition of 10 high-impact general surgery journals, delineate how board composition has changed over time, and evaluate qualification metrics by gender. BACKGROUND: Underrepresentation of women on editorial boards may contribute to the gender-based achievement gap in surgery. METHODS: We performed a cross-sectional analysis of the editorial board gender composition among 10 high-impact general surgery journals in 1997, 2007, and 2017...
January 16, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29338236/detection-of-the-cytotoxic-penitrems-a-f-in-cheese-from-the-european-single-market-eu-by-hplc-ms-ms
#5
Svetlana Kalinina, Annika Jagels, Sebastian Hickert, Lucas Maciel Mauriz Marques, Benedikt Cramer, Hans-Ulrich Humpf
Penitrems are fungal indole diterpene derived tremorgenic secondary metabolites, which are mainly produced by Penicillium spp. Several cases of intoxications with penitrems and subsequent occurrences of penitrem A in foodstuff underline the need for reliable quantitation methods for the detection of these mycotoxins in food. In this study, a simple and fast HPLC-MS/MS method for the quantitative analysis of penitrems A-F in cheese was developed. Therefore, penitrems A-F were isolated from Penicillium crustosum as analytical reference standards...
January 16, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29337650/the-association-of-external-transfer-status-with-adverse-outcomes-in-otolaryngology
#6
Krish Suresh, Christopher J Gouveia, Robert C Kern, John D Cramer
Objective To compare rates of morbidity and mortality in patients treated by otolaryngologists who undergo interhospital transfers vs those who do not and to quantify conditions requiring interhospital transfers in this population. Study Design Cohort study. Setting American College of Surgeons National Surgical Quality Improvement Program. Subjects and Methods We identified patients requiring surgery by otolaryngologists in the National Surgical Quality Improvement Program database from 2006 to 2013. We compared patients who were transferred from an outside institution to those admitted from home...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29333574/unique-metabolic-activation-of-adipose-tissue-macrophages-in-obesity-promotes-inflammatory-responses
#7
Lily Boutens, Guido J Hooiveld, Sourabh Dhingra, Robert A Cramer, Mihai G Netea, Rinke Stienstra
AIMS/HYPOTHESIS: Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance, yet changes in their intracellular energy metabolism are currently unknown. We therefore set out to study metabolic signatures of adipose tissue macrophages (ATMs) in lean and obese conditions...
January 14, 2018: Diabetologia
https://www.readbyqxmd.com/read/29328316/optimized-phase-sensing-in-a-truncated-su-1-1-interferometer
#8
Prasoon Gupta, Bonnie L Schmittberger, Brian E Anderson, Kevin M Jones, Paul D Lett
Homodyne detection is often used for interferometers based on nonlinear optical gain media. For the configuration of a seeded, "truncated SU(1,1)" interferometer Anderson, et al. [ Phys. Rev. A95, 063843 (2017)] showed how to optimize the homodyne detection scheme and demonstrated theoretically that it can saturate the quantum Cramer-Rao bound for phase estimation. In this work we extend those results by taking into account loss in the truncated SU(1,1) interferometer and determining the optimized homodyne detection scheme for phase measurement...
January 8, 2018: Optics Express
https://www.readbyqxmd.com/read/29328101/precision-of-proportion-estimation-with-binary-compressed-raman-spectrum
#9
Philippe Réfrégier, Camille Scotté, Hilton B de Aguiar, Hervé Rigneault, Frédéric Galland
The precision of proportion estimation with binary filtering of a Raman spectrum mixture is analyzed when the number of binary filters is equal to the number of present species and when the measurements are corrupted with Poisson photon noise. It is shown that the Cramer-Rao bound provides a useful methodology to analyze the performance of such an approach, in particular when the binary filters are orthogonal. It is demonstrated that a simple linear mean square error estimation method is efficient (i.e., has a variance equal to the Cramer-Rao bound)...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29323544/transabdominal-ultrasound-detection-of-pancreatic-cysts-incidentally-detected-at-ct-mri-or-endoscopic-ultrasound
#10
Ju Hyun Jeon, Jung Hoon Kim, Ijin Joo, Seunghyun Lee, Seo-Youn Choi, Joon Koo Han
OBJECTIVE: The objective of our study was to evaluate the detection rate of incidental pancreatic cysts on transabdominal ultrasound (TAUS) as well as factors influencing detection rates. MATERIALS AND METHODS: Nine hundred thirty-eight patients with 1064 pancreatic cysts who underwent both TAUS and other imaging examinations including CT, MRI, or endoscopic ultrasound (EUS) were enrolled. We reviewed formal reports and assessed the effect of cyst size and location and the effect of the correlative images for cyst detection on TAUS...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29321336/neuroimaging-identifies-patients-most-likely-to-respond-to-a-restorative-stroke-therapy
#11
Jessica M Cassidy, George Tran, Erin B Quinlan, Steven C Cramer
BACKGROUND AND PURPOSE: Patient heterogeneity reduces statistical power in clinical trials of restorative therapies. Valid predictors of treatment responsiveness are needed, and several have been studied with a focus on corticospinal tract (CST) injury. We studied performance of 4 such measures for predicting behavioral gains in response to motor training therapy. METHODS: Patients with subacute-chronic hemiparetic stroke (n=47) received standardized arm motor therapy, and change in arm Fugl-Meyer score was calculated from baseline to 1 month post-therapy...
January 10, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29315915/a-comparison-of-2-hydroxyglutarate-detection-at-3-and-7%C3%A2-t-with-long-te-semi-laser
#12
Adam Berrington, Natalie L Voets, Sarah J Larkin, Nick de Pennington, James Mccullagh, Richard Stacey, Christopher J Schofield, Peter Jezzard, Stuart Clare, Tom Cadoux-Hudson, Puneet Plaha, Olaf Ansorge, Uzay E Emir
Abnormally high levels of the 'oncometabolite' 2-hydroxyglutarate (2-HG) occur in many grade II and III gliomas, and correlate with mutations in the genes of isocitrate dehydrogenase (IDH) isoforms. In vivo measurement of 2-HG in patients, using magnetic resonance spectroscopy (MRS), has largely been carried out at 3 T, yet signal overlap continues to pose a challenge for 2-HG detection. To combat this, several groups have proposed MRS methods at ultra-high field (≥7 T) where theoretical increases in signal-to-noise ratio and spectral resolution could improve 2-HG detection...
January 5, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29315410/standard-chemoradiation-in-combination-with-vegf-targeted-therapy-for-glioblastoma-results-in-progressive-gray-and-white-matter-volume-loss
#13
Morgan L Prust, Kourosh Jafari-Khouzani, Jayashree Kalpathy-Cramer, Pavlina Polaskova, Tracy T Batchelor, Elizabeth R Gerstner, Jorg Dietrich
No abstract text is available yet for this article.
January 5, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29314131/editorial-irritable-bowel-syndrome-in-addition-to-having-properly-trained-dietitians-is-it-time-to-add-a-yoga-teacher-to-our-multidisciplinary-team-authors-reply
#14
EDITORIAL
D Schumann, H Cramer
No abstract text is available yet for this article.
February 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29305967/phase-sensitivity-evaluation-and-its-application-to-phase-shifting-interferometry
#15
Shichao Chen, Yizheng Zhu
In quantitative phase imaging, sensitivity is a key measure of system reproducibility. Despite continuous experimental breakthroughs in achieving highly sensitive detection, in-depth studies of theoretical constraints on sensitivity are inadequate and comparisons between different techniques are difficult. In this paper, we introduce the method to evaluate the sensitivity of phase shifting interferometry which is a major category of quantitative phase imaging techniques. The method discusses in detail several key concepts of sensitivity evaluation, including a general three-level evaluation framework, a complete interference signal model, Cramér-Rao bound and algorithm sensitivity, algorithm and system efficiencies, as well as energy efficiency of an algorithm...
January 3, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29303562/cluster-dependent-charge-transfer-dynamics-in-iron-sulfur-proteins
#16
Ziliang Mao, Shu-Hao Liou, Nimesh Khadka, Francis E Jenney, David B Goodin, Lance C Seefeldt, Michael W W Adams, Stephen Cramer, Delmar S Larsen
Photo-induced charge-transfer dynamics and the influence of cluster size on the dynamics were investigated using five iron-sulfur clusters: the 1Fe-4S cluster in Pyrococcos furiosus rubredoxin, the 2Fe-2S cluster in Pseudomonas putida putidaredoxin, the 4Fe-4S cluster in nitrogenase iron protein, and the 8Fe-7S P-cluster and the 7Fe-9S-1Mo FeMo cofactor in nitrogenase MoFe protein. Laser excitation promotes the iron-sulfur clusters to excited electronic states that relax to lower states. The electronic relaxation lifetimes of the 1Fe-4S, the 8Fe-7S, and the 7Fe-9S-1Mo clusters are in the picoseconds timescale, although the dynamics of the MoFe protein is a mixture of the dynamics of the later two clusters...
January 5, 2018: Biochemistry
https://www.readbyqxmd.com/read/29295653/improvement-of-fatigue-physical-functioning-and-well-being-among-patients-with-severe-impairment-at-baseline-receiving-ibrutinib-in-combination-with-bendamustine-and-rituximab-for-relapsed-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-in-the-helios
#17
Paula Cramer, Graeme Fraser, Rodrigo Santucci-Silva, Sebastian Grosicki, Marie-Sarah Dilhuydy, Ann Janssens, Javier Loscertales, Simon Rule, Andre Goy, Shana Traina, Eric K H Chan, Joris Diels, Nishan Sengupta, Michelle Mahler, Mariya Salman, Angela Howes, Asher Chanan-Khan
Health-related quality of life (HRQoL) is an important endpoint, especially in clinical trials for malignancies with a long course of disease, such as chronic lymphocytic leukemia (CLL). Patient-reported outcomes were examined in the randomized, double-blind, placebo-controlled HELIOS study to assess the impact of treatment with the Bruton's tyrosine kinase inhibitor ibrutinib, added to bendamustine plus rituximab (BR) background therapy. Measures included FACIT-Fatigue, EORTC QLQ-C30, QLQ-CLL16, and EQ-5D-5L...
January 3, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29294790/the-gay-panic-defense-legal-defense-strategy-or-reinforcement-of-homophobia-in-court
#18
Jenna Tomei, Robert J Cramer, Marcus T Boccaccini, Nancy Ryba Panza
Gay panic refers to a heterosexual man violently responding to unwanted sexual advances from a gay man. In court, the defendant may argue he was provoked or temporarily insane. This study utilized 352 jury-eligible citizens to assess differences across mediums of gay panic. Participants were asked to read vignettes depicting a control, gay panic as provocation, or gay panic as insanity condition and provide verdicts and ratings of blame and responsibility. Participants also completed measures assessing political orientation and homonegativity...
June 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29291238/developmental-emergence-of-phenotypes-in-the-auditory-brainstem-nuclei-of-fmr1-knockout-mice
#19
Sarah E Rotschafer, Karina S Cramer
Fragile X syndrome (FXS), the most common monogenic cause of autism, is often associated with hypersensitivity to sound. Several studies have shown abnormalities in the auditory brainstem in FXS; however, the emergence of these auditory phenotypes during development has not been described. Here, we investigated the development of phenotypes in FXS model [Fmr1 knockout (KO)] mice in the ventral cochlear nucleus (VCN), medial nucleus of the trapezoid body (MNTB), and lateral superior olive (LSO). We studied features of the brainstem known to be altered in FXS or Fmr1 KO mice, including cell size and expression of markers for excitatory (VGLUT) and inhibitory (VGAT) synapses...
November 2017: ENeuro
https://www.readbyqxmd.com/read/29290450/evaluation-of-agreement-among-digital-dermatitis-scoring-methods-in-the-milking-parlor-pen-and-hoof-trimming-chute
#20
G Cramer, T Winders, L Solano, D H Kleinschmit
Digital dermatitis (DD) is the most common infectious foot lesion affecting welfare and productivity of dairy cattle. The key to DD control programs is routine and frequent identification of DD lesions. The objective was to evaluate accuracy of detecting and scoring DD lesions in 3 milking parlor designs and in 3 alternative settings compared with scoring in the hoof trimming chute as reference. A total of 552 cows and 1,104 hind feet from 17 freestall farms were scored by 1 observer in the milking parlor and in 1 other setting: pen, headlocks, or management rail...
December 28, 2017: Journal of Dairy Science
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