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https://www.readbyqxmd.com/read/28942200/frozen-lattice-and-absorptive-model-for-high-angle-annular-dark-field-scanning-transmission-electron-microscopy-a-comparison-study-in-terms-of-integrated-intensity-and-atomic-column-position-measurement
#1
M Alania, I Lobato, S Van Aert
In this paper, both the frozen lattice (FL) and the absorptive potential (AP) approximation models are compared in terms of the integrated intensity and the precision with which atomic columns can be located from an image acquired using high angle annular dark field (HAADF) scanning transmission electron microscopy (STEM). The comparison is made for atoms of Cu, Ag, and Au. The integrated intensity is computed for both an isolated atomic column and an atomic column inside an FCC structure. The precision has been computed using the so-called Cramér-Rao Lower Bound (CRLB), which provides a theoretical lower bound on the variance with which parameters can be estimated...
September 12, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28941057/cooperative-effects-between-chiral-cpxiriii-catalysts-and-chiral-carboxylic-acids-in-enantioselective-c-h-amidations-of-phosphine-oxides
#2
Nicolai Cramer, Yun-Suk Jang, Michael Dieckmann
An enantioselective C-H amidation of phosphine oxides by using an iridium(III) catalyst bearing an atropchiral cyclopentadienyl (Cpx) ligand is reported. A very strong cooperative effect between the chiral Cpx ligand and a phthaloyl tert-leucine enabled the transformation. Matched-mismatched cases of the different acid enantiomers are shown. The amidated P-chiral arylphosphine oxides are formed in yields of up to 95 % and with excellent enantioselectivities of up to 99:1 er. Enantiospecific reduction provides access to valuable P-chiral phosphorus(III) compounds...
September 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28934920/agreed-definitions-and-a-shared-vision-for-new-standards-in-stroke-recovery-research-the-stroke-recovery-and-rehabilitation-roundtable-taskforce
#3
Julie Bernhardt, Kathryn S Hayward, Gert Kwakkel, Nick S Ward, Steven L Wolf, Karen Borschmann, John W Krakauer, Lara A Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer
The first Stroke Recovery and Rehabilitation Roundtable established a game changing set of new standards for stroke recovery research. Common language and definitions were required to develop an agreed framework spanning the four working groups: translation of basic science, biomarkers of stroke recovery, measurement in clinical trials and intervention development and reporting. This paper outlines the working definitions established by our group and an agreed vision for accelerating progress in stroke recovery research...
September 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28932853/the-role-of-ligand-redox-non-innocence-in-ring-opening-polymerization-reactions-catalysed-by-bis-imino-pyridine-iron-alkoxide-complexes
#4
K R Delle Chiaie, A B Biernesser, M A Ortuño, B Dereli, D A Iovan, M J T Wilding, B Li, C J Cramer, J A Byers
The reactivity of iron-based ring opening polymerization catalysts is compared when the catalyst is in three different oxidation states. Formally iron(i) monoalkoxide complexes 3a (p-methoxyphenoxide) and 3b (neopentoxide) supported by bis(imino)pyridine ligands were synthesized and investigated as catalysts for the ring opening polymerization and copolymerization of various monomers. For most monomers, 3a and 3b were superior catalysts compared to analogous, formally iron(ii) and iron(iii) complexes (1a/1b and 2a/2b, respectively) for the ring opening polymerization of various cyclic ester and cyclic carbonate monomers...
September 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28925264/space-environment-effects-on-flexible-low-voltage-organic-thin-film-transistors
#5
Laura Basiricò, Alberto Francesco Basile, Piero Cosseddu, Simone Gerardin, Tobias Cramer, Marta Bagatin, Andrea Ciavatti, Alessandro Paccagnella, Annalisa Bonfiglio, Beatrice Fraboni
Organic electronic devices fabricated on flexible substrates are promising candidates for applications in environments where flexible, light-weight and radiation hard materials are required. In this work, device parameters as threshold voltage, charge mobility and trap density of 13-Bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene) based OTFTs have been monitored performing electrical measurements before and after irradiation by high-energy protons. The observed reduction of charge carrier mobility following irradiation can be only partially ascribed to the increased trap density...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28922271/the-impact-of-telemedicine-on-pediatric-critical-care-triage
#6
Jillian B Harvey, Brooke E Yeager, Christina Cramer, David Wheeler, S David McSwain
OBJECTIVE: To examine the relationship between pediatric critical care telemedicine consultation to rural emergency departments and triage decisions. We compare the triage location and provider rating of the accuracy of remote assessment for a cohort of patients who receive critical care telemedicine consultations and a similar group of patients receiving telephone consultations. DESIGN: Retrospective evaluation of consultations occurring between April 2012 and March 2016...
September 15, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28921614/an-optimized-framework-for-quantitative-magnetization-transfer-imaging-of-the-cervical-spinal-cord-in-vivo
#7
Marco Battiston, Francesco Grussu, Andrada Ianus, Torben Schneider, Ferran Prados, James Fairney, Sebastien Ourselin, Daniel C Alexander, Mara Cercignani, Claudia A M Gandini Wheeler-Kingshott, Rebecca S Samson
PURPOSE: To develop a framework to fully characterize quantitative magnetization transfer indices in the human cervical cord in vivo within a clinically feasible time. METHODS: A dedicated spinal cord imaging protocol for quantitative magnetization transfer was developed using a reduced field-of-view approach with echo planar imaging (EPI) readout. Sequence parameters were optimized based in the Cramer-Rao-lower bound. Quantitative model parameters (i.e., bound pool fraction, free and bound pool transverse relaxation times [ T2F, T2B], and forward exchange rate [kFB ]) were estimated implementing a numerical model capable of dealing with the novelties of the sequence adopted...
September 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28917587/early-or-late-radiotherapy-following-gross-or-subtotal-resection-for-atypical-meningiomas-clinical-outcomes-and-local-control
#8
Ammoren Dohm, Emory R McTyre, Michael D Chan, Claire Fan, Scott Isom, J Daniel Bourland, Ryan T Mott, Christina K Cramer, Stephen B Tatter, Adrian W Laxton
We report a single institution series of surgery followed by either early adjuvant or late radiotherapy for atypical meningiomas (AM). AM patients, by WHO 2007 definition, underwent subtotal resection (STR) or gross total resection (GTR). Sixty-three of a total 115 patients then received fractionated or stereotactic radiation treatment, early adjuvant radiotherapy (≤4months after surgery) or late radiotherapy (at the time of recurrence). Kaplan Meier method was used for survival analysis with competing risk analysis used to assess local failure...
September 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28916637/effect-of-increases-in-cardiac-contractility-on-cerebral-blood-flow-in-humans
#9
Shigehiko Ogoh, Gilbert Moralez, Takuro Washio, Satyam Sarma, Michinari Hieda, Steven A Romero, Matthew N Cramer, Manabu Shibasaki, Craig G Crandall
The effect of acute increases in cardiac contractility on cerebral blood flow (CBF) remains unknown. We hypothesized that the external carotid artery (ECA) downstream vasculature modifies the direct influence of acute increases in heart rate and cardiac function on CBF regulation. Twelve healthy subjects received two infusions of dobutamine (first a low dose; 5 μg/kg/min and then a high dose; 15 μg/kg/min) for 12 min each. Cardiac output, blood flow through the internal carotid artery (ICA) and ECA and echocardiographic measurements were performed during dobutamine infusions...
September 15, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28913930/accuracy-repeatability-and-interplatform-reproducibility-of-t1-quantification-methods-used-for-dce-mri-results-from-a-multicenter-phantom-study
#10
Octavia Bane, Stefanie J Hectors, Mathilde Wagner, Lori L Arlinghaus, Madhava P Aryal, Yue Cao, Thomas L Chenevert, Fiona Fennessy, Wei Huang, Nola M Hylton, Jayashree Kalpathy-Cramer, Kathryn E Keenan, Dariya I Malyarenko, Robert V Mulkern, David C Newitt, Stephen E Russek, Karl F Stupic, Alina Tudorica, Lisa J Wilmes, Thomas E Yankeelov, Yi-Fei Yen, Michael A Boss, Bachir Taouli
PURPOSE: To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T1 quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T. METHODS: A T1 phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery)...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28905419/fast-3d-rosette-spectroscopic-imaging-of-neocortical-abnormalities-at-3-t-assessment-of-spectral-quality
#11
Claudiu V Schirda, Tiejun Zhao, Victor E Yushmanov, Yoojin Lee, Gena R Ghearing, Frank S Lieberman, Ashok Panigrahy, Hoby P Hetherington, Jullie W Pan
PURPOSE: To use a fast 3D rosette spectroscopic imaging acquisition to quantitatively evaluate how spectral quality influences detection of the endogenous variation of gray and white matter metabolite differences in controls, and demonstrate how rosette spectroscopic imaging can detect metabolic dysfunction in patients with neocortical abnormalities. METHODS: Data were acquired on a 3T MR scanner and 32-channel head coil, with rosette spectroscopic imaging covering a 4-cm slab of fronto-parietal-temporal lobes...
September 14, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28894197/a-multi-institutional-comparison-of-dynamic-contrast-enhanced-magnetic-resonance-imaging-parameter-calculations
#12
Rachel B Ger, Abdallah S R Mohamed, Musaddiq J Awan, Yao Ding, Kimberly Li, Xenia J Fave, Andrew L Beers, Brandon Driscoll, Hesham Elhalawani, David A Hormuth, Petra J van Houdt, Renjie He, Shouhao Zhou, Kelsey B Mathieu, Heng Li, Catherine Coolens, Caroline Chung, James A Bankson, Wei Huang, Jihong Wang, Vlad C Sandulache, Stephen Y Lai, Rebecca M Howell, R Jason Stafford, Thomas E Yankeelov, Uulke A van der Heide, Steven J Frank, Daniel P Barboriak, John D Hazle, Laurence E Court, Jayashree Kalpathy-Cramer, Clifton D Fuller
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides quantitative metrics (e.g. K(trans), ve) via pharmacokinetic models. We tested inter-algorithm variability in these quantitative metrics with 11 published DCE-MRI algorithms, all implementing Tofts-Kermode or extended Tofts pharmacokinetic models. Digital reference objects (DROs) with known K(trans) and ve values were used to assess performance at varying noise levels. Additionally, DCE-MRI data from 15 head and neck squamous cell carcinoma patients over 3 time-points during chemoradiotherapy were used to ascertain K(trans) and ve kinetic trends across algorithms...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892040/structure-of-a-transcribing-rna-polymerase-ii-dsif-complex-reveals-a-multidentate-dna-rna-clamp
#13
Carrie Bernecky, Jürgen M Plitzko, Patrick Cramer
During transcription, RNA polymerase II (Pol II) associates with the conserved elongation factor DSIF. DSIF renders the elongation complex stable and functions during Pol II pausing and RNA processing. We combined cryo-EM and X-ray crystallography to determine the structure of the mammalian Pol II-DSIF elongation complex at a nominal resolution of 3.4 Å. Human DSIF has a modular structure with two domains forming a DNA clamp, two domains forming an RNA clamp, and one domain buttressing the RNA clamp. The clamps maintain the transcription bubble, position upstream DNA, and retain the RNA transcript in the exit tunnel...
September 11, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/28891693/radiography-and-ultrasonography-in-the-backyard-poultry-and-waterfowl-patient
#14
Maria-E Krautwald-Junghanns, Torsten Moerke-Schindler, Susanne Vorbrüggen, Kerstin Cramer
The keeping of backyard poultry and waterfowl as pets has become increasingly popular in recent years, resulting in a rising case load of these patients in veterinary practices. Diagnostic imaging techniques are taking a leading role in rapid diagnosis in the live bird. We provide an overview of the most important points regarding radiographic and ultrasonographic imaging procedures in these birds. We also review the most commonly documented radiographic and ultrasonographic signs in these species, as well as discuss unique anatomic characteristics with which the veterinarian should be familiar...
September 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28884886/one-step-multigram-scale-biomimetic-synthesis-of-psiguadial-b
#15
Nicolai Cramer, Christopher Gordon Newton
A gram-scale synthesis of psiguadial B, a purported potent inhibitor of human hepatoma cell growth, has been achieved in one-step via a biomimetic three-component coupling of caryophyllene, benzaldehyde and diformylphloroglucinol. This cascade reaction is catalyzed by N,N'-dimethylethylenediamine, and proceeds at ambient temperature to generate four stereocenters, two rings, one C-O bond, and three C-C bonds. Combined computational and experimental investigations suggest the biosynthesis of the natural product is non-enzyme mediated, and is the result of a Michael addition between caryophyllene and a reactive ortho-quinone methide, followed by two sequential intramolecular cationic cyclization events...
September 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28883164/routine-data-analyses-to-compare-outpatient-depression-treatment-regimens
#16
Robin Siegel, Thomas Ostermann, Reinhard Schuster, Timo Emcke
BACKGROUND: Routine data analyses are becoming increasingly important for health policy decision making. However such databases often vary in data quality, completeness and accessibility. The aim of this study is to describe the quality of a large outpatient healthcare database, the process of data extraction and to give a brief overview of data-structure with focusing on provider-type and disease severity in an example of the treatment of depressive disorders. METHOD: The quality of the database is described and diagnosis rates of depression in outpatient care (ICD-10 diagnoses F32/33) in relation to the provider-type (i...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28883073/sterilizing-immunity-in-the-lung-relies-on-targeting-fungal-apoptosis-like-programmed-cell-death
#17
Neta Shlezinger, Henriette Irmer, Sourabh Dhingra, Sarah R Beattie, Robert A Cramer, Gerhard H Braus, Amir Sharon, Tobias M Hohl
Humans inhale mold conidia daily and typically experience lifelong asymptomatic clearance. Conidial germination into tissue-invasive hyphae can occur in individuals with defects in myeloid function, although the mechanism of myeloid cell-mediated immune surveillance remains unclear. By monitoring fungal physiology in vivo, we demonstrate that lung neutrophils trigger programmed cell death with apoptosis-like features in Aspergillus fumigatus conidia, the most prevalent human mold pathogen. An antiapoptotic protein, AfBIR1, opposes this process by inhibiting fungal caspase activation and DNA fragmentation in the murine lung...
September 8, 2017: Science
https://www.readbyqxmd.com/read/28882532/helminthic-infections-in-returning-travelers-and-migrants-with-eosinophilia-diagnostic-value-of-medical-history-eosinophil-count-and-ige
#18
Helmut J F Salzer, Thierry Rolling, Christof D Vinnemeier, Egbert Tannich, Stefan Schmiedel, Marylyn M Addo, Jakob P Cramer
OBJECTIVES: Eosinophilia in travelers and migrants returning from the tropics is often associated with invasive helminthic infections. Total IgE is considered a useful additional diagnostic parameter; however, both parameters are also increased in various other non-helminthic diseases. METHODS: We retrospectively evaluated travelers and migrants seen at our department between September 2007 and May 2014. Patients with an absolute eosinophil count ≥500 cells/μl were considered for further analyses...
September 4, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28876309/use-of-patient-delivered-partner-therapy-in-us-college-settings-associations-with-legality-perceived-legality-and-other-sexual-and-reproductive-health-services
#19
Matthew Hogben, Alexandra Caccamo, Oscar Beltran, Ryan Cramer, Melissa A Habel
BACKGROUND: Young adults, including college students, have higher rates of chlamydia than the general population. Patient-delivered partner therapy (PDPT) is a partner treatment option for sex partners of individuals diagnosed with chlamydia or gonorrhea. We examined college health center use of PDPT in a national sample of colleges. METHODS: During 2014 to 2015, we collected data from 482 colleges and universities (55% of 885 surveyed), weighting responses by institutional characteristics abstracted from a national database (eg, 2-year vs 4-year status)...
June 28, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28873325/moving-forward-challenges-and-directions-for-psychopathological-network-theory-and-methodology
#20
Eiko I Fried, Angélique O J Cramer
Since the introduction of mental disorders as networks of causally interacting symptoms, this novel framework has received considerable attention. The past years have resulted in over 40 scientific publications and numerous conference symposia and workshops. Now is an excellent moment to take stock of the network approach: What are its most fundamental challenges, and what are potential ways forward in addressing them? After a brief conceptual introduction, we first discuss challenges to network theory: (1) What is the validity of the network approach beyond some commonly investigated disorders such as major depression? (2) How do we best define psychopathological networks and their constituent elements? And (3) how can we gain a better understanding of the causal nature and real-life underpinnings of associations among symptoms? Next, after a short technical introduction to network modeling, we discuss challenges to network methodology: (4) heterogeneity of samples studied with network analytic models, and (5) a lurking replicability crisis in this strongly data-driven and exploratory field...
August 1, 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
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