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https://www.readbyqxmd.com/read/28540764/japan-flavour-and-fragrance-materials-association-s-safety-assessment-of-food-flavouring-substances-uniquely-used-in-japan-that-belong-to-the-class-of-aliphatic-primary-alcohols-aldehydes-carboxylic-acids-acetals-and-esters-containing-additional-oxygenated
#1
Kenji Saito, Yasuko Hasegawa-Baba, Fumiko Sekiya, Shim-Mo Hayashi, Yoshiharu Mirokuji, Hiroyuki Okamura, Shinpei Maruyama, Atsushi Ono, Madoka Nakajima, Masakuni Degawa, Shogo Ozawa, Makoto Shibutani, Tamio Maitani
We performed a safety evaluation using the procedure devised by the Joint FAO/WHO Expert Committee on Food Additives of the following four flavouring substances that belong to the class of 'aliphatic primary alcohols, aldehydes, carboxylic acids, acetals, and esters containing additional oxygenated functional groups' and are uniquely used in Japan: butyl butyrylacetate, ethyl 2-hydroxy-4-methylpentanoate, 3-hydroxyhexanoic acid and methyl hydroxyacetate. Although no genotoxicity study data were found in the published literature, none of the four substances had chemical structural alerts predicting genotoxicity...
May 25, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28537551/rna-dependent-chromatin-association-of-transcription-elongation-factors-and-pol-ii-ctd-kinases
#2
Sofia Battaglia, Michael Lidschreiber, Carlo Baejen, Phillipp Torkler, Seychelle M Vos, Patrick Cramer
For transcription through chromatin, RNA polymerase (Pol) II associates with elongation factors (EFs). Here we show that many EFs crosslink to RNA emerging from transcribing Pol II in the yeast Saccharomyces cerevisiae. Most EFs crosslink preferentially to mRNAs, rather than unstable non-coding RNAs. RNA contributes to chromatin association of many EFs, including the Pol II serine 2 kinases Ctk1 and Bur1 and the histone H3 methyltransferases Set1 and Set2. The Ctk1 kinase complex binds RNA in vitro, consistent with direct EF-RNA interaction...
May 24, 2017: ELife
https://www.readbyqxmd.com/read/28537379/molecular-rhodium-complexes-supported-on-the-metal-oxide-like-nodes-of-metal-organic-frameworks-and-on-zeolite-hy-catalysts-for-ethylene-hydrogenation-and-dimerization
#3
Varinia Bernales, Dong Yang, Jun Yu, Gamze Gümüşlü, Christopher J Cramer, Bruce C Gates, Laura Gagliardi
Metal-organic frameworks (MOFs) with nodes consisting of zirconium oxide clusters (Zr6) offer new opportunities as supports for catalysts with well-defined, essentially molecular, structures. We used the precursor Rh(C2H4)2(acac) (acac is acetylacetonate) to anchor Rh(I) complexes to the nodes of the MOF UiO-67 and, for comparison, to the zeolite dealuminated HY (DAY). These were characterized experimentally by measurement of catalytic activities and selectivities for ethylene hydrogenation and dimerization in a once-through flow reactor at 298 K and 1 bar...
May 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534211/associations-between-yoga-practice-and-joint-problems-a-cross-sectional-survey-among-9151-australian-women
#4
Romy Lauche, Dania Schumann, David Sibbritt, Jon Adams, Holger Cramer
Yoga exercises have been associated with joint problems recently, indicating that yoga practice might be potentially dangerous for joint health. This study aimed to analyse whether regular yoga practice is associated with the frequency of joint problems in upper middle-aged Australian women. Women aged 62-67 years from the Australian Longitudinal Study on Women's Health (ALSWH) were questioned in 2013 whether they experienced regular joint pain or problems in the past 12 months and whether they regularly practiced yoga...
May 22, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28532832/the-precision-of-peri-oestrous-predictors-of-the-date-of-onset-of-parturition-in-the-bitch
#5
K G M De Cramer, J O Nöthling
Precise prediction of the date of onset of parturition in the bitch is clinically important. The study compared the precision with which four peri-oestrous predictors predict the date of onset of parturition. The predictors evaluated in 24 bitches were: the date of the first or only day of the LH surge, the date on which the concentration of progesterone in the blood plasma first exceeded 6 nmol/L, the date on which the concentration of progesterone in the blood plasma first exceeded 16 nmol/L and the date of onset of cytological dioestrus...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532824/puppy-survival-and-vigor-associated-with-the-use-of-low-dose-medetomidine-premedication-propofol-induction-and-maintenance-of-anesthesia-using-sevoflurane-gas-inhalation-for-cesarean-section-in-the-bitch
#6
K G M De Cramer, K E Joubert, J O Nöthling
The safety of an anesthetic protocol consisting of medetomidine hydrochloride (7 μg/kg iv) as premedicant, propofol, (1-2 mg/kg iv) as induction agent and sevoflurane, at 2% in oxygen for maintenance of anesthesia was studied in 292 cesarean sections (CSs) and 2232 puppies delivered. Medetomidine effects were reversed using atipamezole hydrochloride at 50 μg/puppy sc immediately following delivery and in the bitch iv immediately following surgery. The protocol's safety for puppies was expressed using survival immediately, 2 h and 7 d after delivery, and Apgar scores (measurement starting 15 min after delivery of the last puppy)...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28532782/risk-factors-for-recurrent-cardiovascular-events-before-age-65-years-or-within-2-5%C3%A2-years-of-a-recent-first-cardiovascular-event
#7
M Johanneke van den Berg, Jan Westerink, Yolanda van der Graaf, L Jaap Kappelle, Gert J de Borst, Maarten-Jan M Cramer, Frank L J Visseren
The aim of this study was to quantify the relation between classical risk factors (smoking, diabetes, BMI, waist circumference, blood pressure, and lipids), risk factor targets, and risk of recurrent major atherosclerotic cardiovascular events (MACE). This was first done for recurrent MACE ≤65 years in patients aged <60 years and second for recurrent MACE ≤2.5 years after a first cardiovascular event. Data were used from the Second Manifestations of Arterial Disease study (n = 5,115), a prospective cohort of patients with a recent (≤1 year) first cardiovascular event...
April 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28527547/the-optimal-time-and-method-for-surgical-prewarming-a-comprehensive-review-of-the-literature
#8
Lauren Connelly, Emily Cramer, Quinn DeMott, Jennifer Piperno, Bethany Coyne, Clara Winfield, Michael Swanberg
PURPOSE: Inadvertent hypothermia is a common problem in the operating room. This can contribute to many unfavorable outcomes --rising costs, increased complications, and higher morbidity rates. DESIGN: This review determined the optimal method and time to prewarm a surgical patient to prevent perioperative hypothermia. METHODS: CINAHL and PubMed were searched. Fourteen articles were ultimately included in this review. FINDINGS: Based on the literature reviewed, it was suggested that forced-air warming was most effective in preventing perioperative hypothermia...
June 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28521556/maintenance-of-key-word-signing-in-adults-with-intellectual-disabilities-novel-signed-turns-facilitated-by-partners-consistent-input-and-sign-imitation
#9
Ellen Rombouts, Bea Maes, Inge Zink
The aim of the present study was to examine the relationship between the use of key word signing (KWS) by support staff and by adults with intellectual disabilities (clients) who had experience with using KWS. Specifically, we explored whether these clients were more inclined to use KWS when support staff used KWS or imitated signs. One-to-one conversations between 24 clients and their support staff were filmed and transcribed. Partner turns were coded for communication mode (spoken or signed) and KWS response type (i...
May 18, 2017: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/28514635/specialization-to-extremely-low-nutrient-soils-limits-the-nutritional-adaptability-of-plant-lineages
#10
G Anthony Verboom, William D Stock, Michael D Cramer
Specialization to extreme selective situations promotes the acquisition of traits whose coadaptive integration may compromise evolutionary flexibility and adaptability. We test this idea in the context of the foliar stoichiometry of plants native to the South African Cape. Whereas foliar concentrations of nitrogen, phosphorus (P), potassium (K), calcium, magnesium, and sodium showed strong phylogenetic signal, as did the foliar ratios of these nutrients to P, the same was not true of the corresponding soil values...
June 2017: American Naturalist
https://www.readbyqxmd.com/read/28512519/an-internship-may-not-be-enough-enhancing-bioscience-industry-job-readiness-through-practicum-experiences
#11
Jason M Cramer, Paul T Hamilton
In contrast to the narrowing of options in academic careers, the bioscience industry offers robust employment opportunities for STEM-trained workers, especially those who display both scientific and business talent. Unfortunately, traditional science programs typically lack curricular features that develop this type of worker. The North Carolina State University Master of Microbial Biotechnology (MMB) program facilitates industry-specific experiential learning to fill this training gap. Similar programs often rely on a single industry internship to provide students relevant work experience, but completion of one internship might not suffice to position students for employment in a highly competitive job market...
April 2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28510487/origin-of-the-ttc-values-for-compounds-that-are-genotoxic-and-or-carcinogenic-and-an-approach-for-their-re-evaluation
#12
Alan Boobis, Paul Brown, Mark Timothy David Cronin, James Edwards, Corrado Lodovico Galli, Jay Goodman, Abigail Jacobs, David Kirkland, Mirjam Luijten, Cyril Marsaux, Matthew Martin, Chihae Yang, Heli Miriam Hollnagel
The threshold of toxicological concern (TTC) approach is a resource-effective de minimis method for the safety assessment of chemicals, based on distributional analysis of the results of a large number of toxicological studies. It is being increasingly used to screen and prioritize substances with low exposure for which there is little or no toxicological information. The first step in the approach is the identification of substances that may be DNA-reactive mutagens, to which the lowest TTC value is applied...
May 16, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28506219/sexual-orientation-differences-in-treatment-expectation-alliance-and-outcome-among-patients-at-risk-for-suicide-in-a-public-psychiatric-hospital
#13
Martin Plöderl, Sabine Kunrath, Robert J Cramer, Jen Wang, Larissa Hauer, Clemens Fartacek
BACKGROUND: Sexual minority (SM) individuals (gay, lesbian, bisexual, or otherwise nonheterosexual) are at increased risk for mental disorders and suicide and adequate mental healthcare may be life-saving. However, SM patients experience barriers in mental healthcare that have been attributed to the lack of SM-specific competencies and heterosexist attitudes and behaviors on the part of mental health professionals. Such barriers could have a negative impact on common treatment factors such as treatment expectancy or therapeutic alliance, culminating in poorer treatment outcomes for SM versus heterosexual patients...
May 15, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28503986/minority-stress-model-components-and-affective-well-being-in-a-sample-of-sexual-orientation-minority-adults-living-with-hiv-aids
#14
Robert J Cramer, Alixandra C Burks, Martin Plöderl, Praveen Durgampudi
To date very little literature exists examining theoretically-based models applied to day-to-day positive and negative affective well-being among lesbian, gay, and bisexual (LGB) persons living with HIV/AIDS (PLWHA). Grounded in the perspective of Meyer, I. H. (2003). Prejudice, social stress, and mental health in lesbian, gay, and bisexual populations: Conceptual issues and research evidence. Psychological Bulletin, 129, 674-697. Minority Stress Model, the present study examined HIV- and sexual orientation-related factors influencing affective well-being (i...
May 13, 2017: AIDS Care
https://www.readbyqxmd.com/read/28501586/structural-molecular-biology-a-personal-reflection-on-the-occasion-of-john-kendrew-s-100th-birthday
#15
Patrick Cramer
Here I discuss the development and future of structural molecular biology, concentrating on the eukaryotic transcription machinery, and reflecting on John Kendrew's legacy from a personal perspective.
May 10, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/28501108/vendor-effects-on-murine-gut-microbiota-influence-experimental-abdominal-sepsis
#16
Tobias Hilbert, Folkert Steinhagen, Sebastian Senzig, Nina Cramer, Isabelle Bekeredjian-Ding, Marijo Parcina, Georg Baumgarten, Andreas Hoeft, Stilla Frede, Olaf Boehm, Sven Klaschik
BACKGROUND: Experimental animal models are indispensable components of preclinical sepsis research. Reproducible results highly rely on defined and invariant baseline conditions. Our hypothesis was that the murine gut microbiota varies among different distributors of laboratory animals and that these variations influence the phenotype of abdominal sepsis derived from a bacterial inoculum model (intraperitoneal stool injection). MATERIALS AND METHODS: Male C57BL/6 mice (8-wk old) purchased from Charles River (CR), Janvier (J), and Harlan (H) were sacrificed, and the bacterial composition of feces was analyzed using CHROMagar orientation medium...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28492393/long-term-alcohol-use-patterns-and-hiv-disease-severity
#17
Brandon D L Marshall, Janet P Tate, Kathleen A McGinnis, Kendall J Bryant, Robert L Cook, E Jennifer Edelman, Julie R Gaither, Christopher W Kahler, Don Operario, David A Fiellin, Amy C Justice
OBJECTIVE: We examined the relationship between alcohol use trajectories and HIV disease severity among men and women participating in the Veterans Aging Cohort Study (VACS). DESIGN: Prospective cohort of HIV-infected persons in care at eight US Veterans Health Administration sites. METHODS: Between 2002 and 2010, we assessed alcohol consumption annually using the alcohol use disorders identification test-consumption (AUDIT-C). HIV disease severity was ascertained using the VACS index, a validated measure of morbidity and all-cause mortality...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28484765/assessment-of-electronic-structure-methods-for-the-determination-of-the-ground-spin-states-of-fe-ii-fe-iii-and-fe-iv-complexes
#18
Pragya Verma, Zoltan Varga, Johannes E M N Klein, Christopher J Cramer, Lawrence Que, Donald G Truhlar
Our ability to understand and simulate the reactions catalyzed by iron depends strongly on our ability to predict the relative energetics of spin states. In this work, we studied the electronic structures of Fe(2+) ion, gaseous FeO and 14 iron complexes using Kohn-Sham density functional theory with particular focus on determining the ground spin state of these species as well as the magnitudes of relevant spin-state energy splittings. The 14 iron complexes investigated in this work have hexacoordinate geometries of which seven are Fe(ii), five are Fe(iii) and two are Fe(iv) complexes...
May 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28483654/validity-of-robot-based-assessments-of-upper-extremity-function
#19
Alison McKenzie, Lucy Dodakian, Jill See, Vu Le, Erin Burke Quinlan, Claire Bridgford, Daniel Head, Vy L Han, Steven C Cramer
OBJECTIVE: To examine the validity of 5 robot-based assessments of arm motor function post-stroke. DESIGN: Cross sectional. SETTING: Outpatient clinical research center. PARTICIPANTS: Volunteer sample of 40 participants, age >18 years, 3-6 months post-stroke, with arm motor deficits that had plateaued. INTERVENTION: None. MAIN OUTCOME MEASURES: Clinical standards included the Fugl-Meyer Arm Motor Scale (FMA), and 5 secondary motor outcomes: hand/wrist subsection of the FMA; Action Research Arm Test (ART); Box & Blocks test (B/B); hand subscale of Stroke Impact Scale-2 (SIS); and the Barthel Index (BI)...
May 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28481221/gene-expression-and-mutation-guided-synthetic-lethality-eradicates-proliferating-and-quiescent-leukemia-cells
#20
Margaret Nieborowska-Skorska, Katherine Sullivan, Yashodhara Dasgupta, Paulina Podszywalow-Bartnicka, Grazyna Hoser, Silvia Maifrede, Esteban Martinez, Daniela Di Marcantonio, Elisabeth Bolton-Gillespie, Kimberly Cramer-Morales, Jaewong Lee, Min Li, Artur Slupianek, Daniel Gritsyuk, Sabine Cerny-Reiterer, Ilona Seferynska, Tomasz Stoklosa, Lars Bullinger, Huaqing Zhao, Vera Gorbunova, Katarzyna Piwocka, Peter Valent, Curt I Civin, Markus Muschen, John E Dick, Jean C Y Wang, Smita Bhatia, Ravi Bhatia, Kolia Eppert, Mark D Minden, Stephen M Sykes, Tomasz Skorski
Quiescent and proliferating leukemia cells accumulate highly lethal DNA double-strand breaks that are repaired by 2 major mechanisms: BRCA-dependent homologous recombination and DNA-dependent protein kinase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by poly(ADP)ribose polymerase 1 (PARP1) serve as backups. Here we have designed a personalized medicine approach called gene expression and mutation analysis (GEMA) to identify BRCA- and DNA-PK-deficient leukemias either directly, using reverse transcription-quantitative PCR, microarrays, and flow cytometry, or indirectly, by the presence of oncogenes such as BCR-ABL1...
May 8, 2017: Journal of Clinical Investigation
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