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https://www.readbyqxmd.com/read/28430860/increased-brainstem-perfusion-but-no-blood-brain-barrier-disruption-during-attacks-of-migraine-with-aura
#1
Anders Hougaard, Faisal M Amin, Casper E Christensen, Samaira Younis, Frauke Wolfram, Stig P Cramer, Henrik B W Larsson, Messoud Ashina
The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache...
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28430727/changing-referral-patterns-to-urogynecology
#2
Julia Geynisman-Tan, Oluwateniola Brown, Margaret Mueller, Alix Leader-Cramer, Bhumy Dave, Katarzyna Bochenska, Sarah Collins, Christina Lewicky-Gaupp, Kimberly Kenton
OBJECTIVE: The study aims to identify sources of and changes in referral patterns for pelvic floor disorders. METHODS: All new patient visits to urogynecology at our institution between January 2010 and December 2015 were identified. Patient demographics, referral source, insurance type, and visit diagnoses using ICD-9 codes were abstracted. ICD-9 codes were grouped into 18 urogynecologic diagnoses. Data were analyzed using SPSS (Version 20; Chicago, IL). RESULTS: Five thousand seven hundred ninety-nine new patient visits were included in the analysis...
April 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28430500/thermalization-and-return-to-equilibrium-on-finite-quantum-lattice-systems
#3
Terry Farrelly, Fernando G S L Brandão, Marcus Cramer
Thermal states are the bedrock of statistical physics. Nevertheless, when and how they actually arise in closed quantum systems is not fully understood. We consider this question for systems with local Hamiltonians on finite quantum lattices. In a first step, we show that states with exponentially decaying correlations equilibrate after a quantum quench. Then, we show that the equilibrium state is locally equivalent to a thermal state, provided that the free energy of the equilibrium state is sufficiently small and the thermal state has exponentially decaying correlations...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430022/safety-by-design-of-printed-multilayer-materials-intended-for-food-packaging
#4
Celia Domeño, Margarita Aznar, Cristina Nerín, Francesca Isella, Mauro Fedeli, Osvaldo Bosetti
Printing inks are commonly used in multilayer plastics materials used for food packaging and compounds present in inks can migrate to the food either by diffusion through the multilayers or because of set-off phenomena. To avoid this problem the right design of the packaging is crucial. In this work, the safety by design of multilayer materials has been studied. First, the migration from 4 different multilayers manufactured using polyethylene terephthalate (PET), aluminium (Al) and polyethylene (PE) was determined...
April 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28427776/autoantibody-biomarkers-for-the-detection-of-serous-ovarian-cancer
#5
Benjamin A Katchman, Diego Chowell, Garrick Wallstrom, Allison F Vitonis, Joshua LaBaer, Daniel W Cramer, Karen S Anderson
Objective The purpose of this study was to identify a panel of novel serum tumor antigen-associated autoantibody (TAAb) biomarkers for the diagnosis of high-grade serous ovarian cancer. METHODS: To detect TAAb we probed high-density programmable protein microarrays (NAPPA) containing 10,247 antigens with sera from patients with serous ovarian cancer (n=30 cases/30 healthy controls) and measured bound IgG. We identified 735 promising tumor antigens and evaluated these with an independent set of serous ovarian cancer sera (n=30 cases/30 benign disease controls/30 healthy controls)...
April 17, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28426429/a-candidate-liquid-chromatography-mass-spectrometry-reference-method-for-the-quantification-of-the-cardiac-marker-1-32-b-type-natriuretic-peptide
#6
Attila F Torma, Kate Groves, Sabine Biesenbruch, Chris Mussell, Alan Reid, Steve Ellison, Rainer Cramer, Milena Quaglia
BACKGROUND: B-type natriuretic peptide (BNP) is a 32 amino acid cardiac hormone routinely measured by immunoassays to diagnose heart failure. While it is reported that immunoassay results can vary up to 45%, no attempt of standardization and/or harmonization through the development of certified reference materials (CRMs) or reference measurement procedures (RMPs) has yet been carried out. METHODS: B-type natriuretic peptide primary calibrator was quantified traceably to the International System of Units (SI) by both amino acid analysis and tryptic digestion...
April 20, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28426348/traumatic-brain-injury-and-lifetime-suicidality-applying-the-interpersonal-psychological-theory-perspective
#7
Claire N Bryson, Robert J Cramer, Adam T Schmidt
The present paper investigates the traumatic brain injury (TBI)-suicide link, assessing whether: (a) TBI accounts for variance in suicide risk, and (b) The Interpersonal-Psychological Theory of Suicide can be applied to TBI status. Matched case-control procedures applied to archival college student health data identified TBI and non-TBI subsamples (84 total). Individuals with a TBI possessed higher suicide risk than those without. Even accounting for the relative influence of strong suicide risk factors (i...
April 20, 2017: Death Studies
https://www.readbyqxmd.com/read/28423062/filamentous-fungal-carbon-catabolite-repression-supports-metabolic-plasticity-and-stress-responses-essential-for-disease-progression
#8
Sarah R Beattie, Kenneth M K Mark, Arsa Thammahong, Laure Nicolas Annick Ries, Sourabh Dhingra, Alayna K Caffrey-Carr, Chao Cheng, Candice C Black, Paul Bowyer, Michael J Bromley, Joshua J Obar, Gustavo H Goldman, Robert A Cramer
Aspergillus fumigatus is responsible for a disproportionate number of invasive mycosis cases relative to other common filamentous fungi. While many fungal factors critical for infection establishment are known, genes essential for disease persistence and progression are ill defined. We propose that fungal factors that promote navigation of the rapidly changing nutrient and structural landscape characteristic of disease progression represent untapped clinically relevant therapeutic targets. To this end, we find that A...
April 19, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28421171/tactile-stimulation-to-stimulate-spontaneous-breathing-during-stabilization-of-preterm-infants-at-birth-a-retrospective-analysis
#9
Janneke Dekker, Tessa Martherus, Sophie J E Cramer, Henriette A van Zanten, Stuart B Hooper, Arjan B Te Pas
BACKGROUND AND AIMS: Tactile maneuvers to stimulate breathing in preterm infants are recommended during the initial assessment at birth, but it is not known how often and how this is applied. We evaluated the occurrence and patterns of tactile stimulation during stabilization of preterm infants at birth. METHODS: Recordings of physiological parameters and videos of infants <32 weeks gestational age were retrospectively analyzed. Details of tactile stimulation during the first 7 min after birth (timing, duration, type, and indication) were noted...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28417663/is-neck-dissection-associated-with-an-increased-risk-of-postoperative-stroke
#10
John D Cramer, Urjeet A Patel, Matthew B Maas, Sandeep Samant, Stephanie Shintani Smith
Objective Prior studies have reported widely disparate rates of postoperative stroke, with conflicting analyses of whether neck dissection is an independent risk factor. Study Design Cohort study. Setting American College of Surgeons National Surgical Quality Improvement Program from 2005 to 2013. Subjects and Methods We compared the 30-day rate of postoperative stroke between patients undergoing complete or modified radical neck dissection and a control cohort composed of those undergoing resections in the oral cavity, oropharynx, larynx, or hypopharynx without neck dissection...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28409819/spermicidal-efficacy-of-vrp-a-synthetic-cationic-antimicrobial-peptide-inducing-apoptosis-and-membrane-disruption
#11
Prasanta Ghosh, Arpita Bhoumik, Sudipta Saha, Sandipan Mukherjee, Sarfuddin Azmi, Jimut Kanti Ghosh, Sandhya Rekha Dungdung
Presently available contraceptives are mostly hormonal or detergent in nature with numerous side effects like irritation, lesion, inflammation in vagina, alteration of body homeostasis etc. Antimicrobial peptides with spermicidal activity but without adverse effects may be suitable alternatives. In the present study spermicidal activity of a cationic antimicrobial peptide VRP on human spermatozoa has been elucidated. Progressive forward motility of human spermatozoa was instantly stopped after 100 µM VRP treatment and at 350 µM all kinds of sperm motility ceased within 20 seconds as assessed by the Sander-Cramer assay...
April 14, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28408604/architecture-of-a-transcribing-translating-expressome
#12
R Kohler, R A Mooney, D J Mills, R Landick, P Cramer
DNA transcription is functionally coupled to messenger RNA (mRNA) translation in bacteria, but how this is achieved remains unclear. Here we show that RNA polymerase (RNAP) and the ribosome of Escherichia coli can form a defined transcribing and translating "expressome" complex. The cryo-electron microscopic structure of the expressome reveals continuous protection of ~30 nucleotides of mRNA extending from the RNAP active center to the ribosome decoding center. The RNAP-ribosome interface includes the RNAP subunit α carboxyl-terminal domain, which is required for RNAP-ribosome interaction in vitro and for pronounced cell growth defects upon translation inhibition in vivo, consistent with its function in transcription-translation coupling...
April 14, 2017: Science
https://www.readbyqxmd.com/read/28406498/atomic-layer-deposition-of-cu-i-oxide-films-using-cu-ii-bis-dimethylamino-2-propoxide-and-water
#13
J R Avila, A W Peters, Zhanyong Li, M A Ortuño, A B F Martinson, C J Cramer, J T Hupp, O K Farha
To grow films of Cu2O, bis-(dimethylamino-2-propoxide)Cu(ii), or Cu(dmap), is used as an atomic layer deposition precursor using only water vapor as a co-reactant. Between 110 and 175 °C, a growth rate of 0.12 ± 0.02 Å per cycle was measured using an in situ quartz crystal microbalance (QCM). X-ray photoelectron spectroscopy (XPS) confirms the growth of metal-oxide films featuring Cu(i).
April 13, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28406308/magnon-mode-selective-spin-transport-in-compensated-ferrimagnets
#14
Joel Cramer, Er-Jia Guo, Stephan Geprägs, Andreas Kehlberger, Yurii P Ivanov, Kathrin Ganzhorn, Francesco Della Coletta, Matthias Althammer, Hans Huebl, Rudolf Gross, Jurgen Kosel, Mathias Kläui, Sebastian T B Goennenwein
We investigate the generation of magnonic thermal spin currents and their mode selective spin transport across interfaces in insulating, compensated ferrimagnet/normal metal bilayer systems. The spin Seebeck effect signal exhibits a non-monotonic temperature dependence with two sign changes of the detected voltage signals. Using different ferrimagnetic garnets, we demonstrate the universality of the observed complex temperature dependence of the spin Seebeck effect. To understand its origin, we systematically vary the interface between the ferrimagnetic garnet and the metallic layer, and by using different metal layers we establish that interface effects play a dominating role...
April 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28404485/state-level-gonorrhea-rates-and-expedited-partner-therapy-laws-insights-from-time-series-analyses
#15
K Owusu-Edusei, R Cramer, H W Chesson, T L Gift, J S Leichliter
OBJECTIVE: In this study, we examined state-level monthly gonorrhea morbidity and assessed the potential impact of existing expedited partner therapy (EPT) laws in relation to the time that the laws were enacted. STUDY DESIGN: Longitudinal study. METHODS: We obtained state-level monthly gonorrhea morbidity (number of cases/100,000 for males, females and total) from the national surveillance data. We used visual examination (of morbidity trends) and an autoregressive time series model in a panel format with intervention (interrupted time series) analysis to assess the impact of state EPT laws based on the months in which the laws were enacted...
March 24, 2017: Public Health
https://www.readbyqxmd.com/read/28401684/the-effects-of-smoking-status-and-smoking-history-on-patients-with-brain-metastases-from-lung-cancer
#16
Rachel F Shenker, Emory R McTyre, Jimmy Ruiz, Kathryn E Weaver, Christina Cramer, Natalie K Alphonse-Sullivan, Michael Farris, William J Petty, Marcelo R Bonomi, Kounosuke Watabe, Adrian W Laxton, Stephen B Tatter, Graham W Warren, Michael D Chan
There is limited data on the effects of smoking on lung cancer patients with brain metastases. This single institution retrospective study of patients with brain metastases from lung cancer who received stereotactic radiosurgery assessed whether smoking history is associated with overall survival, local control, rate of new brain metastases (brain metastasis velocity), and likelihood of neurologic death after brain metastases. Patients were stratified by adenocarcinoma versus nonadenocarcinoma histologies. Kaplan-Meier analysis was performed for survival endpoints...
April 12, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28401132/comparing-diagnostic-classification-of-neurobehavioral-disorder-associated-with-prenatal-alcohol-exposure-with-the-canadian-fetal-alcohol-spectrum-disorder-guidelines-a-cohort-study
#17
James L Sanders, Rebecca E Hudson Breen, Nicole Netelenbos
BACKGROUND: Diagnostic criteria have recently been introduced in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), for neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE). The purpose of this study is to assess the classification of this condition using the Canadian fetal alcohol spectrum disorder (FASD) multidisciplinary diagnostic guidelines as the standard of comparison. First, classification of ND-PAE was compared with Canadian FASD diagnoses of fetal alcohol syndrome (FAS), partial FAS and alcohol-related neurodevelopmental disorder...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28399533/naturheilkunde-und-komplement%C3%A3-re-verfahren-in-der-nationalen-versorgungsleitlinie-%C3%A2-nicht-spezifischer-kreuzschmerz%C3%A2-erfahrungen-aus-der-%C3%A2-k%C3%A3-nigsklasse%C3%A2
#18
Anna K Koch, Petra Klose, Gustav Dobos, Holger Cramer, Jost Langhorst
No abstract text is available yet for this article.
April 12, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28396494/lipocalin-2-from-both-myeloid-cells-and-epithelium-combats-klebsiella-pneumoniae-lung-infection-in-mice
#19
Elisabeth P Cramer, Sara L Dahl, Björn Rozell, Kasper Jermiin Knudsen, Kim Thomsen, Claus Moser, Jack B Cowland, Niels Borregaard
No abstract text is available yet for this article.
April 10, 2017: Blood
https://www.readbyqxmd.com/read/28390926/rhodopsin-in-plasma-from-patients-with-diabetic-retinopathy-development-and-validation-of-digital-elisa-by-single-molecule-array-simoa-technology
#20
Eva Rabing Brix Petersen, Dorte Aalund Olsen, Henry Christensen, Søren Berndt Hansen, Cramer Christensen, Ivan Brandslund
BACKGROUND: Diabetic retinopathy (DR) is the most frequent cause of blindness among younger adults in the western world. No blood biomarkers exist to detect DR. Hypothetically, Rhodopsin concentrations in blood has been suggested as an early marker for retinal damage. The aim of this study was therefore to develop and validate a Rhodopsin assay by employing digital ELISA technology, and to investigate whether Rhodopsin concentrations in diabetes patients with DR are elevated compared with diabetes patients without DR...
April 5, 2017: Journal of Immunological Methods
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