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https://www.readbyqxmd.com/read/29031520/executive-function-responses-to-aerobic-exercise-in-alzheimer-s-disease
#1
Fang Yu, David M Vock, Terry R Barclay
Executive dysfunction occurs early and is prevalent in Alzheimer's disease (AD). This study tested the ability of different measures for identifying changes in executive function and the effect of 6-months of aerobic exercise on executive function in older adults with mild to moderate AD, using a single-group, repeated-measures design (n = 28, age 78.1 ± 8.37). Factor analysis and linear mixed-effects model analyses showed that individually the Exit Interview-25 (EXIT-25), Behavioral Dyscontrol Scale (BDS), and Golden Stroop test were the preferred instruments for measuring changes in executive function in the sample...
October 11, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29029478/effects-of-exercise-on-capillaries-in-the-white-matter-of-transgenic-ad-mice
#2
Yi Zhang, Feng-Lei Chao, Chun-Ni Zhou, Lin Jiang, Lei Zhang, Lin-Mu Chen, Yan-Min Luo, Qian Xiao, Yong Tang
Previous studies have shown that exercise can prevent white matter atrophy in APP/PS1 transgenic Alzheimer's disease (AD) mice. However, the mechanism of this protective effect remains unknown. To further understand this issue, we investigated the effects of exercise on the blood supply of white matter in transgenic AD mice. Six-month-old male APP/PS1 mice were randomly divided into a control group and a running group, and age-matched non-transgenic littermates were used as a wild-type control group. Mice in the running group ran on a treadmill at low intensity for four months...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28986925/cerebral-blood-flow-in-normal-aging-adults-cardiovascular-determinants-clinical-implications-and-aerobic-fitness
#3
REVIEW
Takashi Tarumi, Rong Zhang
Senescence is a leading cause of mortality, disability, and non-communicable chronic diseases in older adults. Mounting evidence indicates that the presence of cardiovascular disease and risk factors elevates the incidence of both vascular cognitive impairment and Alzheimer's disease (AD). Age-related declines in cardiovascular function may impair cerebral blood flow (CBF) regulation, leading to the disruption of neuronal micro-environmental homeostasis. The brain is the most metabolically active organ with limited intracellular energy storage and critically depends on CBF to sustain neuronal metabolism...
October 6, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28983833/correction-to-moderate-treadmill-exercise-protects-synaptic-plasticity-of-the-dentate-gyrus-and-related-signaling-cascade-in-a-rat-model-of-alzheimer-s-disease
#4
An T Dao, Munder A Zagaar, Karim A Alkadhi
The original version of this article unfortunately does not include the second affiliating institution of Dr. Munder A. Zagaar. "Department of Pharmacy Pracce and Clinical Health Sciences, Texas Southern University, Houston, TX 77004" should have been included on the paper.
October 5, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28983832/correction-to-comparison-of-the-effect-of-exercise-on-late-phase-ltp-of-the-dentate-gyrus-and-ca1-of-alzheimer-s-disease-model
#5
An T Dao, Munder A Zagaar, Amber T Levine, Karim A Alkadhi
The original version of this article unfortunately does not include the second affiliating institution of Dr. Munder A. Zagaar. "Department of Pharmacy Pracce and Clinical Health Sciences, Texas Southern University, Houston, TX 77004" should have been included on the paper.
October 5, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28971004/short-term-mechanisms-influencing-volumetric-brain-dynamics
#6
REVIEW
Nikki Dieleman, Huiberdina L Koek, Jeroen Hendrikse
With the use of magnetic resonance imaging (MRI) and brain analysis tools, it has become possible to measure brain volume changes up to around 0.5%. Besides long-term brain changes caused by atrophy in aging or neurodegenerative disease, short-term mechanisms that influence brain volume may exist. When we focus on short-term changes of the brain, changes may be either physiological or pathological. As such determining the cause of volumetric dynamics of the brain is essential. Additionally for an accurate interpretation of longitudinal brain volume measures by means of neurodegeneration, knowledge about the short-term changes is needed...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28940148/physical-activity-in-preventing-alzheimer-s-disease-and-cognitive-decline-a-narrative-review
#7
REVIEW
Stefano Brini, Hamid R Sohrabi, Jeremiah J Peiffer, Mira Karrasch, Heikki Hämäläinen, Ralph N Martins, Timothy J Fairchild
A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer's disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohorts, outcome measures, and the adopted PA intervention. The primary objective of this narrative review is to evaluate the extant evidence on the relationship between PA, cognitive decline and AD in older populations...
September 23, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28936936/-treatment-of-dementia
#8
K Blom, G A H van den Elsen, H L Koek, J B Sanders, H C Kruithof, J A H R Claassen
- Treatment options for patients with dementia are limited. This article provides an overview of possible interventions, both pharmaceutical and non-pharmaceutical, for Alzheimer's disease, vascular dementia and mixed dementia.- Pharmaceutical treatment options include cholinesterase inhibitors, memantine and experimental medication. Cholinesterase inhibitors are only recommended for Alzheimer's disease and mixed dementia, not for vascular dementia or mild cognitive impairment. There is no proof of effectiveness for the other pharmaceutical options...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28929899/nutrition-as-a-component-of-dementia-risk-reduction-strategies
#9
Carol E Greenwood, Matthew D Parrott
According to the Alzheimer Society of Canada, within the next generation, Canada will experience a more than doubling of individuals living with dementia and a potentially economically crippling 10-fold increase in costs to Canadians. Up to 50% of cases with dementia can be attributed to seven modifiable, predominantly vascular and/or lifestyle-associated, risk factors. Multi-modal dementia risk reduction strategies, targeting diet, exercise, mental stimulation, and vascular risk monitoring, are likely to be the most successful...
January 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28912696/swing-boat-inducing-and-recording-locomotor-activity-in-a-drosophila-melanogaster-model-of-alzheimer-s-disease
#10
Johannes Berlandi, Fang-Ju Lin, Oliver Ambrée, Dirk Rieger, Werner Paulus, Astrid Jeibmann
Recent studies indicate that physical activity can slow down progression of neurodegeneration in humans. To date, automated ways to induce activity have been predominantly described in rodent models. To study the impact of activity on behavior and survival in adult Drosophila melanogaster, we aimed to develop a rotating tube device "swing boat" which is capable of monitoring activity and sleep patterns as well as survival rates of flies. For the purpose of a first application, we tested our device on a transgenic fly model of Alzheimer's disease (AD)...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28910193/lifestyle-markers-predict-cognitive-function
#11
Steven C Masley, Richard Roetzheim, Gwendolyn Clayton, Angela Presby, Kelley Sundberg, Lucas V Masley
OBJECTIVE: Rates of mild cognitive impairment and Alzheimer's disease are increasing rapidly. None of the current treatment regimens for Alzheimer's disease are effective in arresting progression. Lifestyle choices may prevent cognitive decline. This study aims to clarify which factors best predict cognitive function. METHODS: This was a prospective cross-sectional analysis of 799 men and women undergoing health and cognitive testing every 1 to 3 years at an outpatient center...
September 14, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28903738/a-randomized-controlled-trial-of-physical-activity-with-individual-goal-setting-and-volunteer-mentors-to-overcome-sedentary-lifestyle-in-older-adults-at-risk-of-cognitive-decline-the-indigo-trial-protocol
#12
Kay L Cox, Elizabeth V Cyarto, Christopher Etherton-Beer, Kathryn A Ellis, Helman Alfonso, Linda Clare, Danny Liew, David Ames, Leon Flicker, Osvaldo P Almeida, Dina LoGiudice, Nicola T Lautenschlager
BACKGROUND: Increasing physical activity (PA) effectively in those who are inactive is challenging. For those who have subjective memory complaints (SMC) or mild cognitive impairment (MCI) this is a greater challenge necessitating the need for more engaging and innovative approaches. The primary aim of this trial is to determine whether a home-based 6-month PA intervention with individual goal-setting and peer mentors (GM-PA) can significantly increase PA levels in insufficiently active older adults at increased risk of developing Alzheimer's disease (AD)...
September 13, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28900376/physical-activity-and-beta-amyloid-pathology-in-alzheimer-s-disease-a-sound-mind-in-a-sound-body
#13
REVIEW
Khadije Ebrahimi, Alireza Majdi, Behrouz Baghaiee, Seyed Hojjat Hosseini, Saeed Sadigh-Eteghad
Alzheimer's disease (AD) is the most common type of dementia worldwide. Since curative treatment has not been established for AD yet and due to heavy financial and psychological costs of patients' care, special attention has been paid to preventive interventions such as physical activity. Evidence shows that physical activity has protective effects on cognitive function and memory in AD patients. Several pathologic factors are involved in AD-associated cognitive impairment some of which are preventable by physical activity...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28862041/the-use-of-free-non-dementia-specific-apps-on-ipad-to-conduct-group-communication-exercises-for-individuals-with-alzheimer-s-disease-innovative-practice
#14
Anthony Pak-Hin Kong
This study examined the use of various iPad Apps to conduct group cognitive exercises for clients with mild or early stage dementia of Alzheimer's type. A list of free non-dementia-specific Apps suitable for group sessions was compiled. The procedures in choosing these Apps and determining the most successful ones for group exercises were discussed. Based on participants' and professionals' responses to the use of these Apps, the results would render practitioners useful guidelines in replicating and running technology-based training for individuals with dementia...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28851451/structured-physical-exercise-improves-neuropsychiatric-symptoms-in-acute-dementia-care-a-hospital-based-rct
#15
Tim Fleiner, Hannah Dauth, Marleen Gersie, Wiebren Zijlstra, Peter Haussermann
BACKGROUND: The primary objective of this trial is to investigate the effects of a short-term exercise program on neuropsychiatric signs and symptoms in acute hospital dementia care. METHODS: Within a hospital-based randomized controlled trial, the intervention group conducted a 2-week exercise program with four 20-min exercise sessions on 3 days per week. The control group conducted a social stimulation program. Effects on neuropsychiatric signs and symptoms were measured via the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change, the Neuropsychiatric Inventory, and the Cohen-Mansfield Agitation Inventory...
August 29, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28831611/dementia-specific-training-for-nursing-home-staff-a%C3%A2-systematic-literature-review
#16
REVIEW
Julia Riesch, Lucy Meyer, Bosco Lehr, Thomas Severin
BACKGROUND: For people with dementia high-quality care is vital, since at present dementia cannot be cured. In nursing homes this care is provided by the staff, who therefore require dementia-specific training enabling them to improve the quality of life for people with dementia. OBJECTIVE: This article compares existing dementia-specific training for nursing home staff with recommendations, based on the current state of research, by the Alzheimer's Association and the National Institute for Health and Care Excellence, and discusses the outcome of this training...
August 22, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28814391/filling-the-void-a-role-for-exercise-induced-bdnf-and-brain-amyloid-precursor-protein-processing
#17
Rebecca Ek MacPherson
Inactivity, obesity, and insulin resistance are significant risk factors for the development of Alzheimer's disease (AD). Several studies have demonstrated that diet induced obesity, inactivity, and insulin resistance exacerbates neuropathological hallmarks of AD. The aggregation of beta-amyloid peptides is one of these hallmarks. Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in amyloid precursor protein (APP) processing, leading to beta-amyloid peptide formation...
August 16, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28809651/effectiveness-of-occupational-therapy-interventions-to-enhance-occupational-performance-for-adults-with-alzheimer-s-disease-and-related-major-neurocognitive-disorders-a-systematic-review
#18
Stacy Smallfield, Cindy Heckenlaible
OBJECTIVE: The purpose of this systematic review was to describe the evidence for the effectiveness of interventions designed to establish, modify, and maintain occupations for adults with Alzheimer's disease (AD) and related neurocognitive disorders. METHOD: Titles and abstracts of 2,597 articles were reviewed, of which 256 were retrieved for full review and 52 met inclusion criteria. U.S. Preventive Services Task Force levels of certainty and grade definitions were used to describe the strength of evidence...
September 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28806762/a-becn1-mutation-mediates-hyperactive-autophagic-sequestration-of-amyloid-oligomers-and-improved-cognition-in-alzheimer-s-disease
#19
Altea Rocchi, Soh Yamamoto, Tabitha Ting, Yuying Fan, Katherine Sadleir, Yigang Wang, Weiran Zhang, Sui Huang, Beth Levine, Robert Vassar, Congcong He
Impairment of the autophagy pathway has been observed during the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal deposition of extracellular and intracellular amyloid β (Aβ) peptides. Yet the role of autophagy in Aβ production and AD progression is complex. To study whether increased basal autophagy plays a beneficial role in Aβ clearance and cognitive improvement, we developed a novel genetic model to hyperactivate autophagy in vivo. We found that knock-in of a point mutation F121A in the essential autophagy gene Beclin 1/Becn1 in mice significantly reduces the interaction of BECN1 with its inhibitor BCL2, and thus leads to constitutively active autophagy even under non-autophagy-inducing conditions in multiple tissues, including brain...
August 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28800328/effects-of-exercise-on-cognitive-function-in-older-people-with-dementia-a-randomized-controlled-trial
#20
Annika Toots, Håkan Littbrand, Gustaf Boström, Carl Hörnsten, Henrik Holmberg, Lillemor Lundin-Olsson, Nina Lindelöf, Peter Nordström, Yngve Gustafson, Erik Rosendahl
BACKGROUND: Although physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia. OBJECTIVES: To investigate effects of exercise on cognitive function in people with dementia. METHOD: The Umeå Dementia and Exercise (UMDEX) study, a cluster-randomized controlled trial, was set in 16 nursing homes in Umeå, Sweden. One hundred-and-forty-one women and 45 men with dementia; mean age of 85 y and mean Mini-Mental State Examination (MMSE) score of 15, were randomized to a High-Intensity Functional Exercise program or a seated attention control activity...
2017: Journal of Alzheimer's Disease: JAD
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