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https://www.readbyqxmd.com/read/28078981/resilience-to-alzheimer-s-disease-the-role-of-physical-activity
#1
Pedrinolla Anna, Schena Federico, Venturelli Massimo
BACKGROUND: Although Alzheimer's disease (AD) is a neurodegenerative pathology characterized by accumulation of β-amyloid plaques and neurofibrillary tangles at cerebral level, recent studies highlighted that AD might be the result of many altered physiological processes occurring at whole-organism level. The ability to adapt to stressors by "bending" but not "breaking" can be considered as "resilience". Individuals incline to withstand such pathophysiological challenges, can be considered more resilient than those that do not...
January 11, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28074678/prevention-of-alzheimer-s-disease-cerebrovascular-disease-and-dementia-in-women-the-case-for-menopause-hormone-therapy
#2
Dennis A Davey
Alzheimer's disease, cerebrovascular disease and aging-related cognitive impairment and dementia (ARCID) increase in prevalence in women with advancing age. The development of Alzheimer's disease, cerebrovascular disease and ARCID may be postponed or prevented by protective measures including the active treatment of vascular risk factors and continuing exercise and healthy lifestyle from early- and mid-life onward. Bilateral oophorectomy before the natural menopause is associated with an increased incidence of ARCID and the increased risk is significantly reduced by estrogen therapy...
January 11, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28067736/alzheimer-s-disease-and-exercise-a-literature-review
#3
Shane P Cass
Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs memory and cognitive judgment. It is the leading cause of dementia in late adult life and is associated with a significant social burden and increased morbidity and mortality in the elderly. Because of mixed effectiveness of medications, exercise has been considered as a treatment for pre-clinical AD, late stage AD, and as a prevention strategy. Exercise appears to improve brain blood flow, increase hippocampal volume, and improve neurogenesis...
January 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28064170/cardiorespiratory-fitness-and-brain-volumes-in-men-and-women-in-the-finger-study
#4
Heikki Pentikäinen, Tiia Ngandu, Yawu Liu, Kai Savonen, Pirjo Komulainen, Merja Hallikainen, Miia Kivipelto, Rainer Rauramaa, Hilkka Soininen
BACKGROUND: high cardiorespiratory fitness (CRF) is associated with larger brain volumes but data on sex differences in the association of CRF with brain volumes are scarce. We investigated whether the association of CRF with total grey matter (GM) and white matter volumes as well as medial temporal lobe and striatum volumes is different between men and women at increased risk for Alzheimer's disease (AD). METHODS: we used baseline data from The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) in which the inclusion criteria were set to select individuals with cognitive performance at the mean level or slightly lower than expected for age according to Finnish population norms...
January 6, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28058207/memory-loss-five-new-things
#5
Ferenc Deak, Nidhi Kapoor, Calin Prodan, Linda A Hershey
PURPOSE OF REVIEW: Memory loss can be due to a wide variety of causes. We provide new information about the biology of common genetic and acquired causes of memory loss in older adults. RECENT FINDINGS: New data are available about the genetics of Alzheimer disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia. Amyloid PET, FDG-PET, and MRI have improved our understanding of how mild cognitive impairment evolves to AD. Several studies have shown links between concussion and chronic traumatic encephalopathy...
December 2016: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28057424/sundown-syndrome-sleep-quality-and-walking-among-community-dwelling-people-with-alzheimer-disease
#6
Yen-Hua Shih, Ming-Chyi Pai, Ying-Che Huang, Jing-Jy Wang
PURPOSES: Sundown syndrome and sleep disturbances cause people with Alzheimer disease (PAD) and caregivers suffering. Studies have indicated that physical exercise could have a positive impact on sundown syndrome, yet no research has ever explored the relationship between walking and sundown syndrome. The aims of this study were to examine the relationship between sundown syndrome and sleep quality, and determine whether the severity of dementia, sleep quality, and weekly duration of walking influenced sundown syndrome, and to assess differences in sundown syndrome and sleep quality in relation to the accompanying walker and weekly duration of walking among people with Alzheimer disease living in the community...
January 2, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28039287/vascular-biomarkers-to-predict-response-to-exercise-in-alzheimer-s-disease-the-study-protocol
#7
Danni Li, Robin Thomas, Michael Y Tsai, Ling Li, David M Vock, Susan Greimel, Fang Yu
INTRODUCTION: Exercise interventions are a promising treatment for improving cognition in persons with Alzheimer's disease. This is similar to Alzheimer's disease pharmacotherapies in which only 18-48% of treated patients demonstrate improvement in cognition. Aerobic exercise interventions positively affect brain structure and function through biologically sound pathways. However, an under-studied mechanism of aerobic exercise's effects is n-3 fatty acids in plasma. The objective of this pilot study is to inform a future large-scale study to develop n-3 fatty acids-based prediction of cognitive responses to aerobic exercise treatment in Alzheimer's disease...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/27999771/validation-of-evidence-based-fall-prevention-programs-for-adults-with-intellectual-and-or-developmental-disorders-a-modified-otago-exercise-program
#8
Mindy Renfro, Donna B Bainbridge, Matthew Lee Smith
INTRODUCTION: Evidence-based fall prevention (EBFP) programs significantly decrease fall risk, falls, and fall-related injuries in community-dwelling older adults. To date, EBFP programs are only validated for use among people with normal cognition and, therefore, are not evidence-based for adults with intellectual and/or developmental disorders (IDD) such as Alzheimer's disease and related dementias, cerebral vascular accident, or traumatic brain injury. BACKGROUND: Adults with IDD experience not only a higher rate of falls than their community-dwelling, cognitively intact peers but also higher rates and earlier onset of chronic diseases, also known to increase fall risk...
2016: Frontiers in Public Health
https://www.readbyqxmd.com/read/27978791/exercise-prevents-cognitive-function-decline-and-demyelination-in-the-white-matter-of-app-ps1-transgenic-ad-mice
#9
Lei Zhang, Feng-Lei Chao, Yan-Min Luo, Qian Xiao, Lin Jiang, Chun-Ni Zhou, Yi Zhang, Fu-Lin Lv, Qi He, Jing Ma, Yong Tang
It is unclear whether exercise delays the cognitive function decline and structural changes that occur in Alzheimer's disease (AD). In this study, 6-month-old male APP/PS1 double transgenic mice were exercised by running for 20 min/day for four months, and then the effects of exercise on cognitive function and white matter in these AD mice were investigated. We found that the mean escape latency of the exercised group was significantly decreased compared with that of the sedentary group and that the percentage of time spent in the target quadrant and the target zone frequency were significantly increased...
December 13, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27928511/latino-hispanic-alzheimer-s-caregivers-experiencing-dementia-related-dressing-issues-corroboration-of-the-preservation-of-self-model-and-reactions-to-a-smart-dresser-computer-based-dressing-aid
#10
Diane Feeney Mahoney, David W Coon, Cecil Lozano
OBJECTIVE: To gain an understanding of Latino/Hispanic caregivers' dementia-related dressing issues, their impressions of using a "smart" context-aware dresser to coach dressing, and recommendations to improve its acceptability. METHOD: The same Latina moderator conducted all the caregiver focus groups. She followed a semi-structured interview guide that was previously used with White and African American family caregivers who experienced Alzheimer's disease related dressing challenges...
November 2016: Digit Health
https://www.readbyqxmd.com/read/27911299/chronotropic-response-and-cognitive-function-in-a-cohort-at-risk-for%C3%A2-alzheimer-s-disease
#11
Lena L Law, Stephanie A Schultz, Elizabeth A Boots, Jean A Einerson, Ryan J Dougherty, Jennifer M Oh, Claudia E Korcarz, Dorothy F Edwards, Rebecca L Koscik, N Maritza Dowling, Catherine L Gallagher, Barbara B Bendlin, Cynthia M Carlsson, Sanjay Asthana, Bruce P Hermann, Mark A Sager, Sterling C Johnson, Dane B Cook, James H Stein, Ozioma C Okonkwo
The objective of this study was to examine the association of chronotropic response (CR) and heart rate (HR) recovery- two indices of cardiovascular function within the context of a graded exercise test- with cognitive performance in a cognitively healthy, late-middle-aged cohort at risk for Alzheimer's disease (AD). Ninety participants (age = 63.52±5.86 years; 65.6% female) from the Wisconsin Registry for Alzheimer's Prevention participated in this study. They underwent graded exercise testing and a comprehensive neuropsychological assessment that assessed the following four cognitive domains: Immediate Memory, Verbal & Learning Memory, Working Memory, and Speed & Flexibility...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27909646/the-neural-mechanisms-of-meditative-practices-novel-approaches-for-healthy-aging
#12
REVIEW
Bianca P Acevedo, Sarah Pospos, Helen Lavretsky
OBJECTIVES: Meditation has been shown to have physical, cognitive, and psychological health benefits that can be used to promote healthy aging. However, the common and specific mechanisms of response remain elusive due to the diverse nature of mind-body practices. METHODS: In this review, we aim to compare the neural circuits implicated in focused-attention meditative practices that focus on present-moment awareness to those involved in active-type meditative practices (e...
2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/27908782/adaptive-responses-of-neuronal-mitochondria-to-bioenergetic-challenges-roles-in-neuroplasticity-and-disease-resistance
#13
REVIEW
Sophia M Raefsky, Mark P Mattson
An important concept in neurobiology is "neurons that fire together, wire together" which means that the formation and maintenance of synapses is promoted by activation of those synapses. Very similar to the effects of the stress of exercise on muscle cells, emerging findings suggest that neurons respond to activity by activating signaling pathways (e.g., Ca(2+), CREB, PGC-1α, NF-κB) that stimulate mitochondrial biogenesis and cellular stress resistance. These pathways are also activated by aerobic exercise and food deprivation, two bioenergetic challenges of fundamental importance in the evolution of the brains of all mammals, including humans...
January 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27889467/treadmill-exercise-decreases-amyloid-%C3%AE-burden-possibly-via-activation-of-sirt-1-signaling-in-a-mouse-model-of-alzheimer-s-disease
#14
Jung-Hoon Koo, Eun-Bum Kang, Yoo-Sung Oh, Dae-Seung Yang, Joon-Yong Cho
Accumulation of amyloid-β (Aβ) correlates significantly with progressive cognitive deficits, a main symptom of Alzheimer's disease (AD). Although treadmill exercise reduces Aβ levels, the molecular mechanisms underlying the effects are not fully understood. We hypothesize that treadmill exercise decreases Aβ production and alleviates cognitive deficits by activating the non-amyloidogenic pathway via SIRT-1 signaling. Treadmill exercise improved cognitive deficits and alleviated neurotoxicity. Most importantly, treadmill exercise increased SIRT-1 level, which subsequently resulted in increased ADAM-10 level by down-regulation of ROCK-1 and upregulation of RARβ, ultimately facilitating the non-amyloidogenic pathway...
February 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27887597/technology-enhanced-multi-domain-at-home-continuum-of-care-program-with-respect-to-usual-care-for-people-with-cognitive-impairment-the-ability-telerehabilitation-study-protocol-for-a-randomized-controlled-trial
#15
O Realdon, F Rossetto, M Nalin, I Baroni, M Cabinio, R Fioravanti, F L Saibene, M Alberoni, F Mantovani, M Romano, R Nemni, F Baglio
BACKGROUND: According to the World Alzheimer Report (Prince, The Global Impact of Dementia: an Analysis of Prevalence, Incidence, Cost and Trends, 2015), 46.8 million people worldwide are nowadays living with dementia. And this number is estimated to approximate 131.5 million by 2050, with an increasing burden on society and families. The lack of medical treatments able to stop or slow down the course of the disease has moved the focus of interest toward the nonpharmacological approach and psychosocial therapies for people with/at risk of dementia, as in the Mild Cognitive Impairment (MCI) condition...
November 25, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27875496/exercise-attenuates-high-fat-diet-induced-disease-progression-in-3xtg-ad-mice
#16
Donghyun Kim, Jinkyung Cho, Inhwan Lee, Youngyun Jin, Li Li Ji, Hyunsik Kang
PURPOSE: Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits. This study aimed to investigate the therapeutic effect of treadmill running against HFD-induced progression in AD neuropathology and cognitive impairments in the triple transgenic-AD (3xTg-AD) mice. METHODS: The 3xTg-AD mice were assigned to a chow diet (control, n=10), a high-fat diet (HFD, n=10), or a high-fat diet combined with exercise (HFD+EX, n=10) group...
November 21, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27870597/exercise-training-for-persons-with-alzheimer-s-disease-and-caregivers-a-review-of-dyadic-exercise-interventions
#17
Guillaume Lamotte, Raj C Shah, Orly Lazarov, Daniel M Corcos
Alzheimer's disease (AD) is the most common form of dementia and the prevalence will increase dramatically in the next decades. Although exercise has shown benefits for people with dementia due to AD as well as their caregivers, the impact of a dyadic exercise intervention including both groups as study participants remains to be determined. The authors review the current clinical evidence for dyadic exercise interventions, which are exercise regimens applied to both the person with dementia and the caregiver...
November 21, 2016: Journal of Motor Behavior
https://www.readbyqxmd.com/read/27864047/apoe%C3%AE%C2%B54-impacts-up-regulation-of-brain-derived-neurotrophic-factor-after-a-six-month-stretch-and-aerobic-exercise-intervention-in-mild-cognitively-impaired-elderly-african-americans-a-pilot-study
#18
Joanne S Allard, Oyonumo Ntekim, Steven P Johnson, Julius S Ngwa, Vernon Bond, Dynell Pinder, Richard F Gillum, Thomas V Fungwe, John Kwagyan, Thomas O Obisesan
Possession of the Apolipoprotein E (APOE) gene ε4 allele is the most prevalent genetic risk factor for late onset Alzheimer's disease (AD). Recent evidence suggests that APOE genotype differentially affects the expression of brain-derived neurotrophic factor (BDNF). Notably, aerobic exercise-induced upregulation of BDNF is well documented; and exercise has been shown to improve cognitive function. As BDNF is known for its role in neuroplasticity and survival, its upregulation is a proposed mechanism for the neuroprotective effects of physical exercise...
January 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/27852513/premorbid-exercise-engagement-and-motor-reserve-in-parkinson-s-disease
#19
Mun K Sunwoo, Ji E Lee, Jin Y Hong, Byung S Ye, Hye S Lee, Jungsu S Oh, Jae S Kim, Phil H Lee, Young H Sohn
BACKGROUND: Life-long experiences of cognitive activity could enhance cognitive reserve, which may lead individuals to show less cognitive deficits in Alzheimer's disease, despite similar pathological changes. We performed this study to test whether premorbid physical activity may enhance motor reserve in Parkinson's disease (PD) (i.e., less motor deficits despite similar degrees of dopamine depletion). METHODS: We assessed engagement in premorbid leisure-time exercise among 102 drug naive PD patients who had been initially diagnosed at our hospital by dopamine transporter scanning...
January 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27845490/cognitive-disability-in-alzheimer-s-disease-and-its-management
#20
M Corsi, T Di Raimo, C Di Lorenzo, M Rapp-Ricciardi, T Archer, S Ricci, R Businaro
Cognitive disability linked to neurodegenerative diseases and in particular to Alzheimer's disease, remains an increasing cause for concern through a dramatic prevalence increment and associated socio-economic burdens. Initially Alzheimer's disease develops asymptomatically with primary clinical signs, such as memory impairment, decline of spatial and perceptual abilities, occurring at a later stage. This delay implies the possibility of promoting early interventions during the pre-symptomatic stage of the disease...
September 2016: La Clinica Terapeutica
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