keyword
https://read.qxmd.com/read/38425691/organ-sparing-techniques-and-dose-volume-constrains-used-in-breast-cancer-radiation-therapy-results-from-european-and-latin-american-surveys
#21
JOURNAL ARTICLE
Monica-Emila Chirilă, Fatjona Kraja, Gustavo Nader Marta, Wellington Furtado Pimenta Neves Junior, Gustavo Viani de Arruda, André Guimarães Gouveia, Pierfrancesco Franco, Philip Poortmans, Ivica Ratosa
BACKGROUND: Advances in local and systemic therapies have improved the outcomes of patients with breast cancer (BC), leading to a possible increased risk for postoperative radiation therapy (RT) late adverse events. The most adequate technologies and dose constraints for organs at risk (OAR) in BC RT have yet to be defined. METHODS: An online survey was distributed to radiation oncologists (ROs) practicing in Europe and Latin America including the Caribbean (LAC) through personal contacts, RO and BC professional groups' networks...
May 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38420106/chest-wall-to-heart-distance-reproducibility-in-postoperative-deep-inspiration-breath-hold-radiotherapy-for-left-sided-breast-cancer-using-an-anzai-laser-sensor-with-visual-feedback
#22
JOURNAL ARTICLE
Masataka Hoshina, Masaya Noguchi, Hirotoshi Sekihara, Koichi Masuda, Mitsuko Shinmura, Shinji Sugahara
Background Left-sided breast cancer radiotherapy may increase the risk of cardiovascular death due to possible heart irradiation. The reproducibility of the chest wall to heart distance in deep inspiration breath-hold (DIBH) was studied using a laser sensor with visual feedback. Methodology A total of 10 consecutive postoperative left-sided breast cancer cases receiving DIBH radiotherapy between December 2022 and September 2023 were retrospectively investigated. The prescribed dose was 50 Gy in 25 fractions...
January 2024: Curēus
https://read.qxmd.com/read/38406646/dynamic-changes-in-cardiac-biomarkers-in-radiotherapy-for-oesophageal-cancer-and-their-correlations-with-cardiac-radiation-dosimetry
#23
JOURNAL ARTICLE
Jin-Zhi Wang, Yue Wang, Qian Shao, Jian-Bin Li
BACKGROUND AND PURPOSE: To investigate the dynamic changes in cardiac enzymes, high-sensitivity troponin T (hs-TnT), pro-brain natriuretic peptide (pro-BNP) and left ventricular ejection fraction (LVEF) during radiotherapy (RT) and 6 months after RT for oesophageal squamous cell carcinoma (ESCC) in the middle and lower locations and to analyse the correlations between these indicators and cardiac radiation dosimetry parameters. METHODS: For 35 patients with ESCC in the middle and lower locations receiving radical concurrent chemoradiotherapy (cCRT), intensity-modulated RT was performed at 1...
March 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38398081/dosimetric-impact-of-voluntary-deep-inspiration-breath-hold-dibh-in-mediastinal-hodgkin-lymphomas-a-comparative-evaluation-of-three-different-intensity-modulated-radiation-therapy-imrt-delivery-methods-using-voluntary-dibh-and-free-breathing-techniques
#24
JOURNAL ARTICLE
Samarpita Mohanty, Divya Patil, Kishore Joshi, Poonam Gamre, Ajay Mishra, Sunil Khairnar, Sangeeta Kakoti, Lingaraj Nayak, Sachin Punatar, Jeevanshu Jain, Reena Phurailatpam, Jayant S Goda
Hodgkin lymphomas are radiosensitive and curable tumors that often involve the mediastinum. However, the application of radiation therapy to the mediastinum is associated with late effects including cardiac and pulmonary toxicities and secondary cancers. The adoption of conformal IMRT and deep inspiration breath- hold (DIBH) can reduce the dose to healthy normal tissues (lungs, heart and breast). We compared the dosimetry of organs at risk (OARs) using different IMRT techniques for two breathing conditions, i...
February 6, 2024: Cancers
https://read.qxmd.com/read/38397868/ventricular-tachycardia-catheter-ablation-retrospective-analysis-and-prospective-outlooks-a-comprehensive-review
#25
REVIEW
Laura Adina Stanciulescu, Radu Vatasescu
Ventricular tachycardia is a potentially life-threatening arrhythmia associated with an overall high morbi-mortality, particularly in patients with structural heart disease. Despite their pivotal role in preventing sudden cardiac death, implantable cardioverter-defibrillators, although a guideline-based class I recommendation, are unable to prevent arrhythmic episodes and significantly alter the quality of life by delivering recurrent therapies. From open-heart surgical ablation to the currently widely used percutaneous approach, catheter ablation is a safe and effective procedure able to target the responsible re-entry myocardial circuit from both the endocardium and the epicardium...
January 24, 2024: Biomedicines
https://read.qxmd.com/read/38378473/the-effects-of-radiation-therapy-on-the-heart-implications-for-management
#26
JOURNAL ARTICLE
Kristin Hsieh, Alexandra E Hotca, Juliana Runnels, Daniel Cherry, Julie R Bloom, Catherine Yu, Anthony D Nehlsen, Lucas Resende Salgado, Kunal K Sindhu
Chemotherapy, radiotherapy, and surgery constitute the three primary modalities employed in the treatment of patients with cancer. Radiotherapy, in particular, is a mainstay of treatment for patients with cancers of the breast, esophagus, lung, and lymph nodes. Prior studies have shown, however, that radiotherapy can impact the heart. Radiation exposure, in fact, can lead to pathophysiological changes that may result in short- and long-term radiation-induced cardiac toxicities. Such toxicities can cause substantial morbidity and may manifest clinically in the weeks to years after the completion of treatment...
February 20, 2024: Chinese Clinical Oncology
https://read.qxmd.com/read/38376288/dosimetric-comparison-of-3dcrt-and-imrt-in-radical-chemoradiotherapy-of-squamous-cell-carcinoma-esophagus
#27
JOURNAL ARTICLE
P Krishnapriya, C D Sivanandan, S Roshni, B Sarin, M H Geethi, K M Jagathnath Krishna
BACKGROUND: Radical chemoradiation is the standard of treatment for locally advanced squamous cell carcinoma of esophagus and for patients with operable disease, but who are medically unfit or unwilling for surgery. As the esophagus is a central organ, the planning target volume (PTV) is central, lies close to the spinal cord and heart, and is surrounded by the lung, which is a radiosensitive organ. Irradiation of these critical structures is reduced by the use of three-dimensional conformal radiation therapy (3DCRT)...
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38369989/artificial-intelligence-based-automated-segmentation-and-radiotherapy-dose-mapping-for-thoracic-normal-tissues
#28
JOURNAL ARTICLE
Jue Jiang, Chloe Min Seo Choi, Joseph O Deasy, Andreas Rimner, Maria Thor, Harini Veeraraghavan
BACKGROUND AND PURPOSE: Objective assessment of delivered radiotherapy (RT) to thoracic organs requires fast and accurate deformable dose mapping. The aim of this study was to implement and evaluate an artificial intelligence (AI) deformable image registration (DIR) and organ segmentation-based AI dose mapping (AIDA) applied to the esophagus and the heart. MATERIALS AND METHODS: AIDA metrics were calculated for 72 locally advanced non-small cell lung cancer patients treated with concurrent chemo-RT to 60 Gy in 2 Gy fractions in an automated pipeline...
January 2024: Physics and Imaging in Radiation Oncology
https://read.qxmd.com/read/38368615/technical-note-minimizing-cied-artifacts-on-a-0-35-t-mri-linac-using-deep-learning
#29
JOURNAL ARTICLE
Austen N Curcuru, Deshan Yang, Hongyu An, Phillip S Cuculich, Clifford G Robinson, H Michael Gach
BACKGROUND: Artifacts from implantable cardioverter defibrillators (ICDs) are a challenge to magnetic resonance imaging (MRI)-guided radiotherapy (MRgRT). PURPOSE: This study tested an unsupervised generative adversarial network to mitigate ICD artifacts in balanced steady-state free precession (bSSFP) cine MRIs and improve image quality and tracking performance for MRgRT. METHODS: Fourteen healthy volunteers (Group A) were scanned on a 0...
February 18, 2024: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38364948/flash-proton-radiation-therapy-mitigates-inflammatory-and-fibrotic-pathways-and-preserves-cardiac-function-in-a-preclinical-mouse-model-of-radiation-induced-heart-disease
#30
JOURNAL ARTICLE
Kyle Kim, Michele M Kim, Giorgos Skoufos, Eric S Diffenderfer, Seyyedeh Azar Oliaei Motlagh, Michail Kokkorakis, Ilektra Koliaki, George Morcos, Khayrullo Shoniyozov, Joanna Griffin, Artemis G Hatzigeorgiou, James M Metz, Alexander Lin, Steven J Feigenberg, Keith A Cengel, Bonnie Ky, Constantinos Koumenis, Ioannis I Verginadis
PURPOSE: Studies during the past 9 years suggest that delivering radiation at dose rates exceeding 40 Gy/s, known as "FLASH" radiation therapy, enhances the therapeutic index of radiation therapy (RT) by decreasing normal tissue damage while maintaining tumor response compared with conventional (or standard) RT. This study demonstrates the cardioprotective benefits of FLASH proton RT (F-PRT) compared with standard (conventional) proton RT (S-PRT), as evidenced by reduced acute and chronic cardiac toxicities...
February 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38340315/advances-in-injectable-hydrogels-for-radiation-induced-heart-disease
#31
JOURNAL ARTICLE
Lu-Yao Zhao, Xin-Yue Wang, Mei-Ling Wen, Ning-Ning Pan, Xing-Qi Yin, Mei-Wen An, Li Wang, Yang Liu, Jian-Bo Song
Radiological heart damage (RIHD) is damage caused by unavoidable irradiation of the heart during chest radiotherapy, with a long latency period and a progressively increasing proportion of delayed cardiac damage due to conventional doses of chest radiotherapy. There is a risk of inducing diseases such as acute/chronic pericarditis, myocarditis, delayed myocardial fibrosis and damage to the cardiac conduction system in humans, which can lead to myocardial infarction or even death in severe cases. This paper details the pathogenesis of RIHD and gives potential targets for treatment at the molecular and cellular level, avoiding the drawbacks of high invasiveness and immune rejection due to drug therapy, medical device implantation and heart transplantation...
February 10, 2024: Journal of Biomaterials Science. Polymer Edition
https://read.qxmd.com/read/38336705/competing-risk-analysis-of-cardiovascular-disease-risk-in-breast-cancer-patients-receiving-a-radiation-boost
#32
JOURNAL ARTICLE
Yvonne Koop, Femke Atsma, Marilot C T Batenburg, Hanneke Meijer, Femke van der Leij, Roxanne Gal, Sanne G M van Velzen, Ivana Išgum, Hester Vermeulen, Angela H E M Maas, Saloua El Messaoudi, Helena M Verkooijen
BACKGROUND: Thoracic radiotherapy may damage the myocardium and arteries, increasing cardiovascular disease (CVD) risk. Women with a high local breast cancer (BC) recurrence risk may receive an additional radiation boost to the tumor bed. OBJECTIVE: We aimed to evaluate the CVD risk and specifically ischemic heart disease (IHD) in BC patients treated with a radiation boost, and investigated whether this was modified by age. METHODS: We identified 5260 BC patients receiving radiotherapy between 2005 and 2016 without a history of CVD...
February 9, 2024: Cardio-Oncology
https://read.qxmd.com/read/38332993/cardiac-volume-reduction-during-radiotherapy-in-patients-with-esophageal-carcinoma
#33
JOURNAL ARTICLE
Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Ayu Makita, Kei Nagasaki
The present study investigated the factors contributing to cardiac volume reduction (CVR) during radiotherapy (RT) in patients with esophageal carcinoma (EC). This retrospective study included patients with EC treated at National Hospital Organization Shikoku Cancer Center (Matsuyama, Japan). Cardiac delineation was based on initial and off-cord boost (spinal cord-sparing approach) planning computed tomography images. The relationship between CVR and other relevant parameters was analyzed. A total of 58 patients with EC were investigated between January 2016 and January 2022...
March 2024: Molecular and Clinical Oncology
https://read.qxmd.com/read/38330892/effects-of-a-music-based-intervention-on-psychophysiological-outcomes-of-patients-undergoing-medical-imaging-procedures-a%C3%A2-systematic-review-and-meta-analysis
#34
REVIEW
L Vieira, C Carvalho, A Grilo, J Reis, A F Pires, E Pereira, E Carolino, M Almeida-Silva
INTRODUCTION: Musical intervention (MI) is a valuable strategy for addressing the psychological and emotional challenges faced by patients undergoing imaging procedures. This study explores MI's impact on psychophysiological outcomes during imaging procedures, detailing the sound repertoire and technical characteristics employed in MI. METHODS: A systematic review (SR) and meta-analysis (MA) were conducted. Electronic database searches of PubMed, Web-of-Science, and Scopus were performed encompassing original randomised research and quasi-experimental articles published until June 2023...
February 7, 2024: Radiography
https://read.qxmd.com/read/38320358/organ-dose-prediction-for-patients-undergoing-radiotherapy-cbct-chest-examinations-using-artificial-intelligence
#35
JOURNAL ARTICLE
Fereniki Tsironi, Marios Myronakis, John Stratakis, Varvara Sotiropoulou, John Damilakis
PURPOSE: To propose an artificial intelligence (AI)-based method for personalized and real-time dosimetry for chest CBCT acquisitions. METHODS: CT images from 113 patients who underwent radiotherapy treatment were collected for simulating thorax examinations using cone-beam computed tomography (CBCT) with the Monte Carlo technique. These simulations yielded organ dose data, used to train and validate specific AI algorithms. The efficacy of these AI algorithms was evaluated by comparing dose predictions with the actual doses derived from Monte Carlo simulations, which are the ground truth, utilizing Bland-Altman plots for this comparative analysis...
February 5, 2024: Physica Medica: PM
https://read.qxmd.com/read/38317205/quantitative-analysis-of-the-impact-of-respiratory-state-on-the-heartbeat-induced-movements-of-the-heart-and-its-substructures
#36
JOURNAL ARTICLE
Benzhe Liang, Guanzhong Gong, Ying Tong, Lizhen Wang, Ya Su, Huadong Wang, Zhenkai Li, Hongyu Yan, Xiaohong Zhang, Yong Yin
PURPOSE: This study seeks to examine the influence of the heartbeat on the position, volume, and shape of the heart and its substructures during various breathing states. The findings of this study will serve as a valuable reference for dose-volume evaluation of the heart and its substructures in radiotherapy for treating thoracic tumors. METHODS: Twenty-three healthy volunteers were enrolled in this study, and cine four-dimensional magnetic resonance images were acquired during periods of end-inspiration breath holding (EIBH), end-expiration breath holding (EEBH), and deep end-inspiration breath holding (DIBH)...
February 5, 2024: Radiation Oncology
https://read.qxmd.com/read/38315236/dosimetric-advantages-for-cardiac-substructures-in-radiotherapy-of-esophageal-cancer-in-deep-inspiration-breath-hold
#37
JOURNAL ARTICLE
Ahmed Allam Mohamed, Melina Nausikaa Douglas, Philipp Bruners, Michael J Eble
BACKGROUND: Radiotherapy is one of the main treatment options for patients with esophageal cancer; however, it has been linked with an increased risk of cardiac toxicities. In the current study, we evaluated the effect of planning the radiation in deep-inspiration breath hold (DIBH) on the dose sparing of cardiac substructures and lung. MATERIALS AND METHODS: In this study, we analyzed 30 radiation therapy plans from 15 patients diagnosed with esophageal cancer planned for neoadjuvant radiotherapy...
February 5, 2024: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://read.qxmd.com/read/38312045/radiation-induced-coronary-artery-disease-during-immune-checkpoint-inhibitor-therapy-a-case-report
#38
JOURNAL ARTICLE
Xiajing Qian, Kequan Ding, Yi Lu
Radiation-induced coronary artery disease (RICAD) poses a serious concern for cancer patients post radiotherapy, typically emerging after over a decade. Immune checkpoint inhibitors (ICIs), known for cardiotoxicity, are increasingly recognized for causing cardiovascular complications. Here we report the case of a 63-year-old man with metastatic lung cancer who developed coronary artery disease during his third-line therapy with an ICI (nivolumab) and an antiangiogenic agent (bevacizumab), 3 years post chest radiotherapy...
February 5, 2024: Immunotherapy
https://read.qxmd.com/read/38307806/cardiovascular-mortality-and-duration-of-androgen-deprivation-in-locally-advanced-prostate-cancer-long-term-update-of-nrg-rtog-9202
#39
JOURNAL ARTICLE
Kimberley S Mak, Molly Scannell Bryan, James J Dignam, William U Shipley, Yue Lin, Christopher A Peters, Elizabeth M Gore, Seth A Rosenthal, Kenneth L Zeitzer, David P D'Souza, Eric M Horwitz, Thomas M Pisansky, Jordan M Maier, Susan M Chafe, Tyler P Robin, Mack Roach, Phuoc T Tran, Luis Souhami, Jeff M Michalski, Alan C Hartford, Felix Y Feng, Howard M Sandler, Jason A Efstathiou
BACKGROUND: Androgen deprivation therapy (ADT) has been associated with coronary heart disease and myocardial infarction (MI) in prostate cancer patients, but controversy persists regarding its effects on cardiovascular mortality (CVM). OBJECTIVE: We assessed the long-term relationship between ADT and CVM in a prostate cancer randomized trial (NRG Oncology/Radiation Therapy Oncology Group 9202). DESIGN, SETTING, AND PARTICIPANTS: From 1992 to 1995, 1554 men with locally advanced prostate cancer (T2c-T4, prostate-specific antigen <150 ng/ml) received radiotherapy with 4 mo (short-term [STADT]) versus 28 mo (longer-term [LTADT]) of ADT...
February 1, 2024: European Urology Focus
https://read.qxmd.com/read/38303923/knowledge-based-versus-deep-learning-based-treatment-planning-for-breast-radiotherapy
#40
JOURNAL ARTICLE
Daniel Portik, Enrico Clementel, Jérôme Krayenbühl, Nienke Bakx, Nicolaus Andratschke, Coen Hurkmans
BACKGROUND AND PURPOSE: To improve radiotherapy (RT) planning efficiency and plan quality, knowledge-based planning (KBP) and deep learning (DL) solutions have been developed. We aimed to make a direct comparison of these models for breast cancer planning using the same training, validation, and testing sets. MATERIALS AND METHODS: Two KBP models were trained and validated with 90 RT plans for left-sided breast cancer with 15 fractions of 2.6 Gy. The versions either used the full dataset (non-clean model) or a cleaned dataset (clean model), thus eliminating geometric and dosimetric outliers...
January 2024: Physics and Imaging in Radiation Oncology
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