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https://www.readbyqxmd.com/read/27906782/predicting-heart-dose-in-breast-cancer-patients-who-received-3d-conformal-radiation-therapy
#1
Daniel Wollschläger, Heiko Karle, Marcus Stockinger, Detlef Bartkowiak, Sandra Bührdel, Hiltrud Merzenich, Thomas Wiegel, Heinz Schmidberger, Maria Blettner
Cardiac late effects are a major health concern for long-term survivors after radiotherapy for breast cancer. Large cohort studies to better understand the exact dose-response relationship require individual estimates of radiation dose to the heart. To predict individual cardiac dose from information that is typically available for all members of a retrospective epidemiological cohort study, 774 female breast cancer patients treated with megavoltage tangential field radiotherapy in 1998-2008 were examined. All dose distributions were calculated using Eclipse with the anisotropic analytical algorithm (AAA) for photon fields and the electron Monte Carlo algorithm for electron boost fields...
January 2017: Health Physics
https://www.readbyqxmd.com/read/27898749/-dosimetric-comparison-of-different-techniques-for-external-beam-accelerated-partial-breast-irradiation
#2
Gábor Stelczer, Tibor Major, Norbert Mészáros, Csaba Polgár, Csilla Pesznyák
The aim of this article is to evaluate and compare four different radiotherapy techniques of accelerated partial breast irradiation (APBI) considering planning quality, dosimetric and practical aspects. The investigated techniques are three dimensional conformal radiotherapy (3D-CRT), "step and shoot" (SS) and "sliding window" (SW) intensity-modulated radiotherapy, intensity-modulated arc therapy (RA). CT scans of 10 patients previously treated with APBI were selected for the study. Surgical clips were placed on the borders of the tumour bed during breast conserving surgery...
November 29, 2016: Magyar Onkologia
https://www.readbyqxmd.com/read/27898429/dosimetric-improvements-with-a-novel-breast-stereotactic-radiotherapy-device-for-delivery-of-preoperative-partial-breast-irradiation
#3
James W Snider Iii, Yildirim Mutaf, Elizabeth Nichols, Andrea Hall, Patrick Vadnais, William F Regine, Steven J Feigenberg
OBJECTIVE: Partial-breast irradiation (PBI) with external-beam radiotherapy has produced higher than expected rates of fair-to-poor cosmesis. Worsened outcomes have been correlated with larger volumes of breast tissue exposed to radiation. A novel breast-specific stereotactic radiotherapy (BSRT) device (BSRTD) has been developed at our institution and has shown promise in delivering highly conformal dose distributions. We compared normal tissue sparing with this device with that achieved with intensity-modulated radiation therapy (IMRT)-PBI...
November 30, 2016: Oncology
https://www.readbyqxmd.com/read/27890346/the-uk-heartspare-study-stage-ii-multicentre-evaluation-of-a-voluntary-breath-hold-technique-in-patients-receiving-breast-radiotherapy
#4
F R Bartlett, E M Donovan, H A McNair, L A Corsini, R M Colgan, P M Evans, L Maynard, C Griffin, J S Haviland, J R Yarnold, A M Kirby
AIMS: To evaluate the feasibility and heart-sparing ability of the voluntary breath-hold (VBH) technique in a multicentre setting. MATERIALS AND METHODS: Patients were recruited from 10 UK centres. Following surgery for early left breast cancer, patients with any heart inside the 50% isodose from a standard free-breathing tangential field treatment plan underwent a second planning computed tomography (CT) scan using the VBH technique. A separate treatment plan was prepared on the VBH CT scan and used for treatment...
November 24, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/27867461/transesophageal-echocardiography-and-radiation-induced-damages
#5
Marzia Cottini, Vincenzo Polizzi, Paolo Giuseppe Pino, Vitaliano Buffa, Francesco Musumeci
The long-term sequelae of mantle therapy include, especially lung and cardiac disease but also involve the vessels and the organs in the neck and thorax (such as thyroid, aorta, and esophagus). We presented the case of 66-year-old female admitted for congestive heart failure in radiation-induced heart disease. The patient had undergone to massive radiotherapy 42 years ago for Hodgkin's disease (type 1A). Transesophageal echocardiography was performed unsuccessfully with difficulty because of the rigidity and impedance of esophageal walls...
July 2016: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/27866953/triple-tandem-high-dose-rate-brachytherapy-for-early-stage-medically-inoperable-endometrial-cancer-initial-report-on-acute-toxicity-and-dosimetric-comparison-to-stereotactic-body-radiation-therapy
#6
Greg Kauffmann, Tianming Wu, Hania Al-Hallaq, Yasmin Hasan
PURPOSE: Stereotactic body radiotherapy (SBRT) may be appealing in medically inoperable endometrial cancer to avoid procedural risks. We performed a dosimetric comparison to triple-tandem, high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: Six consecutive clinical stage I, grade 1-2, medically inoperable endometrial cancer patients were treated with triple-tandem HDR brachytherapy. We report patient factors and acute toxicity. Also, we performed dosimetric comparison to SBRT using both 3D conformal arc (3DArc) and volumetric-modulated arc therapy...
November 17, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27866849/inter-observer-variation-in-delineating-the-coronary-arteries-as-organs-at-risk
#7
Anna-Karin Wennstig, Hans Garmo, Per Hållström, Petra Witt Nyström, Per Edlund, Carl Blomqvist, Malin Sund, Greger Nilsson
PURPOSE: To determine the inter-observer variation in delineating the coronary arteries as organs at risk (OAR) in breast cancer (BC) radiotherapy (RT) and how this variation affects the estimated coronary artery radiation dose. METHOD: Delineation of the left main and the left anterior descending coronary artery (LMCA and LAD), and the right coronary artery (RCA), by using the heart atlas by Feng et al., was performed by three radiation oncologists in 32 women who had received adjuvant RT for BC...
November 17, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27866063/anticancer-therapy-induced-vascular-toxicity-vegf-inhibition-and-beyond
#8
REVIEW
Daniela Di Lisi, Rosalinda Madonna, Concetta Zito, Enrico Bronte, Giuseppe Badalamenti, Paolo Parrella, Ines Monte, Carlo Gabriele Tocchetti, Antonio Russo, Giuseppina Novo
Cardiotoxicity induced by chemotherapeutic agents and radiotherapy is a growing problem. In recent years, an increasing number of new drugs with targeted action have been designed. These molecules, such as monoclonal antibodies and tyrosine kinase inhibitors, can cause different type of toxicities compared to traditional chemotherapy. However, they can also cause cardiac complications such as heart failure, arterial hypertension, QT interval prolongation and arrhythmias. Currently, a field of intense research is the vascular toxicity induced by new biologic drugs, particularly those which inhibit vascular endothelial growth factor (VEGF) and its receptor (VEGF-R) and other tyrosine kinases...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27858317/trends-in-cardiac-mortality-in-women-with-ductal-carcinoma-in-situ
#9
Waqar Haque, Vivek Verma, Anam Haque, E Brian Butler, Bin S Teh
PURPOSE: In certain ductal carcinoma in situ (DCIS) subpopulations, there is no consensus regarding whether to postoperatively irradiate; decisions are often made based on potential risk of cardiac toxicities. Given the utility of Surveillance, Epidemiology, and End Results (SEER) data for studying cardiac mortality in invasive disease, this is the first such study specific for DCIS patients, evaluating trends in cardiac mortality after left-sided radiotherapy (RT). METHODS: The SEER database was queried for patients with DCIS that received RT and had known unilaterality...
November 17, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27853720/performance-evaluation-of-algorithms-in-lung-imrt-a-comparison-of-monte-carlo-pencil-beam-superposition-fast-superposition-and-convolution-algorithms
#10
T Verma, N K Painuly, S P Mishra, M Shajahan, N Singh, M L B Bhatt, N Jamal, M C Pant
BACKGROUND: Inclusion of inhomogeneity corrections in intensity modulated small fields always makes conformal irradiation of lung tumor very complicated in accurate dose delivery. OBJECTIVE: In the present study, the performance of five algorithms via Monte Carlo, Pencil Beam, Convolution, Fast Superposition and Superposition were evaluated in lung cancer Intensity Modulated Radiotherapy planning. MATERIALS AND METHODS: Treatment plans for ten lung cancer patients previously planned on Monte Carlo algorithm were re-planned using same treatment planning indices (gantry angel, rank, power etc...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27842711/-radiation-related-heart-toxicity-update-in-women
#11
S Marlière, E Vautrin, C Saunier, A Chaikh, I Gabelle-Flandin
Breast cancer is a common diagnosis in women and thus women are at risk of radiation-induced heart disease, in particular during radiotherapy for left breast cancer and when the internal mammary chain is included. Rates of major cardiac events increase with younger age at the time of irradiation, diagnosis before 1990s, higher radiation doses, coexisting cardiovascular risk factors and adjuvant cardiotoxic chemotherapy. Radiation-induced heart disease comprises a spectrum of cardiac pathologies, including pericardial disease, cardiomyopathy, coronary artery disease and valvular disease...
November 11, 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27837283/restrictive-cardiomyopathy-delayed-occurrence-after-radiotherapy-of-breast-cancer
#12
Barbara Bellmann, Brunilda Alushi, Boris Bigalke, Ulf Landmesser, Andreas J Morguet
A 74-year-old female patient was referred to our department in 2015 with dyspnea, cough and dysphagia. She had been diagnosed with adenocarcinoma of the right breast in 1986 and underwent mastectomy. When she presented with a local recurrence in 1988, she was receiving high-voltage radiation therapy. Transthoracic echocardiography and magnetic resonance imaging revealed tricuspid regurgitation grade III and unclear right heart failure with a massively dilated right atrium. Coronary heart disease could be ruled out...
November 11, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27836000/unusual-side-effect-from-a-luteinizing-hormone-releasing-hormone-agonist-leuprorelin-in-the-treatment-of-prostate-cancer-a-case-report
#13
John I-Chiang Chang, Joseph Bucci
BACKGROUND: The treatment options for high-risk prostate cancer are either radical prostatectomy or radiotherapy/brachytherapy depending on the patients' prognosis. In older men with multiple comorbidities, radiotherapy with androgen deprivation therapy is an attractive option. Common side effects of androgen deprivation therapy include hot flushes, tiredness, increased risk of fractures, increased risk of metabolic disorders, coronary heart disease, and psychological effects. This case highlights the potential side effect of lipodystrophy secondary to leuprolide acetate injections...
November 11, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27826034/multi-institutional-prospective-study-of-reirradiation-with-proton-beam-radiotherapy-for-locoregionally-recurrent-non-small-cell-lung-cancer
#14
Hann-Hsiang Chao, Abigail T Berman, Charles B Simone, Christine Ciunci, Peter Gabriel, Haibo Lin, Stefan Both, Corey Langer, Kristi Lelionis, Ramesh Rengan, Stephen M Hahn, Kiran Prabhu, Marcio Fagundes, William Hartsell, Rosemarie Mick, John P Plastaras
PURPOSE: The management of recurrent non-small cell lung cancer (NSCLC) in the setting of prior radiation therapy is challenging. Proton radiotherapy (PRT) is ideally suited to minimize toxicity to previously irradiated organs. We report the safety/feasibility of PRT for NSCLC reirradiation in a prospective multi-institutional study. MATERIALS AND METHODS: Between 10/2010-12/2015, 57 patients with recurrent NSCLC in/near their prior radiation field were treated at three proton centers...
November 4, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27822951/rectal-neuroendocrine-neoplasia-a-rare-tumour
#15
Marina de Benito Sanz, Javier Santos Fernández, Mª Henar Núñez Rodríguez
Colorectal neuroendocrine tumours are rare A 78 year old man with a history of hypertension, heart disease, pacemakers, prostate adenocarcinoma.On examination for rectal bleeding, a colonoscopy was performed and at 5 cm of the anal margin a 28 mm ulcerated neoformation was found.An echo-endoscopy revealed infiltration of the muscular layer with an area of loss in the cleavage plane loss and fraying of the perirectal fat infiltration suggestive of infiltration (T3). They no lymph nodes or metastasis were identified by CAT...
November 8, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27805817/the-role-of-tgf-beta-and-ppar-alpha-signalling-pathways-in-radiation-response-of-locally-exposed-heart-integrated-global-transcriptomics-and-proteomics-analysis
#16
Vikram Subramanian, Ingar Seemann, Juliane Merl-Pham, Stefanie M Hauck, Fiona Anne Stewart, Michael J Atkinson, Soile Tapio, Omid Azimzadeh
Epidemiological data from patients undergoing radiotherapy for thoracic tumours clearly show the damaging effect of ionising radiation on cardiovascular system. The long-term impairment of heart function and structure after local high-dose irradiation is associated with systemic inflammatory response, contraction impairment, microvascular damage and cardiac fibrosis. The goal of the present study was to investigate molecular mechanisms involved in this process. C57BL/6J mice received a single X-ray dose of 16 Gy given locally to the heart at the age of 8 weeks...
November 2, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27804053/3d-conformal-radiotherapy-is-not-associated-with-the-long-term-cardiac-mortality-in-breast-cancer-patients-a-retrospective-cohort-study-in-germany-passos-heart-study
#17
Hiltrud Merzenich, Detlef Bartkowiak, Heinz Schmidberger, Marcus Schmidt, Lukas Schwentner, Thomas Wiegel, Achim Woeckel, Daniel Wollschläger, Maria Blettner
PURPOSE: In breast cancer patients treated in the 1970s and 1980s, radiation therapy (RT) for left-sided tumors has been associated with an elevated risk of cardiac mortality. In recent years, improved RT techniques have reduced radiation exposure of the heart and major coronary vessels, but some exposure remains unavoidable. In a retrospective cohort study, we investigated the long-term cardiac mortality risk of breast cancer survivors treated with modern RT in Germany. METHODS: A total of 11,982 women were included who were treated for breast cancer between 1998 and 2008...
November 1, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27798891/chest-wall-deformity-in-the-radiation-oncology-clinic
#18
John M Stahl, Julian C Hong, Nataniel H Lester-Coll, Benjamin H Kann, Lynn D Wilson, Susan A Higgins, Suzanne B Evans
BACKGROUND/AIM: To determine the incidence of pectus excavatum (PE) and define anatomical chest wall metrics predictive of elevated mean heart dose (MHD) in patients with left-sided breast cancer receiving adjuvant radiotherapy. PATIENTS AND METHODS: We reviewed 273 consecutively simulated patients from 1/2013-12/2014. Physical examination identified patients with clinically identifiable PE. Characteristics were compared between patients with and those without PE...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27794475/constitutional-560-49%C3%A2-kb-chromosome-2p24-3-duplication-including-the-mycn-gene-identified-by-snp-chromosome-microarray-analysis-in-a-child-with-multiple-congenital-anomalies-and-bilateral-wilms-tumor
#19
Mark A Micale, Bedford Embrey, Jacqueline K Macknis, Cheryl E Harper, David J Aughton
Fewer than 100 patients with partial chromosome 2p trisomy have been reported. Clinical features are variable and depend on the size of the duplicated segment, but generally include psychomotor delay, facial anomalies, congenital heart defect, and other abnormalities. We report a 560.49 kb duplication of chromosome 2p in a 13 month-old male with hydrocephaly, ventricular septal defect, partial agenesis of the corpus callosum, and bilateral Wilms tumor. After discovery of bilateral renal masses at four months of age, the child underwent neoadjuvant chemotherapy followed by right radical nephrectomy that revealed triphasic Wilms' tumor...
October 26, 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27784326/treatment-planning-and-evaluation-of-gated-radiotherapy-in-left-sided-breast-cancer-patients-using-the-catalyst-tm-sentinel-tm-system-for-deep-inspiration-breath-hold-dibh
#20
S Schönecker, F Walter, P Freislederer, C Marisch, H Scheithauer, N Harbeck, S Corradini, C Belka
BACKGROUND: There is a potential for adverse cardiovascular effects in long-term breast cancer survivors following adjuvant radiotherapy (RT). For this purpose, the deep inspiration breath-hold technique (DIBH) has been introduced into clinical practice, to maximally reduce the radiation dose to the heart. However, there are a variety of DIBH delivery techniques, patient positioning and visual patient feedback mechanisms. The aim of the present study was to evaluate the application of radiotherapy in DIBH using the Catalyst(TM)/Sentinel(TM) system, with a special emphasis on treatment planning and dosimetric plan comparison in free breathing (FB) and DIBH...
October 26, 2016: Radiation Oncology
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