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https://www.readbyqxmd.com/read/28646251/cardiac-dose-sparing-effects-of-deep-inspiration-breath-hold-in-left-breast-irradiation-is-imrt-more-beneficial-than-vmat
#1
Mazen Sakka, Leonie Kunzelmann, Martin Metzger, Gerhard G Grabenbauer
BACKGROUND: Given the reduction in death from breast cancer, as well as improvements in overall survival, adjuvant radiotherapy is considered the standard treatment for breast cancer. However, left-sided breast irradiation was associated with an increased rate of fatal cardiovascular events due to incidental irradiation of the heart. Recently, considerable efforts have been made to minimize cardiac toxicity of left-sided breast irradiation by new treatment methods such as deep-inspiration breath-hold (DIBH) and new radiation techniques, particularly intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT)...
June 23, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28643731/cardiotoxic-effects-of-radiotherapy-and-strategies-to-reduce-them-in-patients-with-breast-cancer-an-overview
#2
REVIEW
Katarzyna Rygiel
Cardiotoxicity of various anticancer therapies, including radiotherapy (RT), can lead to cardiovascular (CV) complications, and their severity depends on many factors, including the site of action, the applied dose, the method of administration, the presence of pre-existing CV diseases, or CV risk factors, the individual patient characteristics, and the current or previous use of antineoplastic therapies. Cardiotoxicity can occur immediately upon administration of the anticancer therapy or it may have a delayed onset (months or years after the treatment)...
April 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28620463/recent-advances-in-the-management-of-wilms-tumor
#3
REVIEW
Roberto I Lopes, Armando Lorenzo
The objective of this article is to present an overview of recent trends in the management of Wilms' tumor. With improved survival rates in the past few decades, critical long-term adverse therapy effects (such as renal insufficiency, secondary malignancies, and heart failure) and prevention measures (i.e. nephron-sparing surgery and minimizing the use of radiotherapy) have gained worldwide attention. Specific disease biomarkers that could help stratify high-risk from low-risk patients, and therefore fine-tune management, are in great demand...
2017: F1000Research
https://www.readbyqxmd.com/read/28618843/risk-of-cardiac-death-among-cancer-survivors-in-the-united-states-a-seer-database-analysis
#4
Omar Abdel-Rahman
 Background: Population-based data on the risk of cardiac death among cancer survivors are needed. This scenario was evaluated in cancer survivors (>5 years) registered within the Surveillance, Epidemiology and End Results (SEER) database. METHODS: The SEER database was queried using SEER*Stat to determine the frequency of cardiac death compared to other causes of death; and to determine heart disease-specific and cancer-specific survival rates in survivors of each of the 10 most common cancers in men and women in the SEER database...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28610630/osteosarcoma-of-the-lower-limb-metastasized-to-the-septum-and-right-side-of-the-heart-a-case-report
#5
Elisha Osati, Alice Kaijage, Reuben Muta, Peter Muhoka, Merckris Mango, Peter Kisenge, Bashir Nyangasa, Pedro Pallangyo, Delillah Kimambo, Mohamed Janabi
BACKGROUND: Metastatic cardiac tumors are far more common than primary tumors. Although the hematogenous spread of osteosarcoma is well known, the imaging findings of cardiovascular involvement by osteosarcoma are seldom reported and can be difficult to recognize. CASE PRESENTATION: A 21-year-old man of African descent presented to our center complaining of shortness of breath, awareness of heart beats, easy fatigability, swelling of lower limbs, and left-side chest discomfort for the past 6 months getting worse for the last 3 months prior to his third readmission...
June 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28606833/impact-of-physiological-breathing-motion-for-breast-cancer-radiotherapy-with-proton-beam-scanning-an-in-silico-study
#6
Anna M Flejmer, Behnaz Chehrazi, Dan Josefsson, Iuliana Toma-Dasu, Alexandru Dasu
This study investigates the impact of breathing motion on proton breast treatment plans. Twelve patients with CT datasets acquired during breath-hold-at-inhalation (BHI), breath-hold-at-exhalation (BHE) and in free-breathing (FB) were included in the study. Proton plans were designed for the left breast for BHI and subsequently recalculated for BHE or designed for FB and recalculated for the extreme breath-hold phases. The plans were compared from the point of view of their target coverage and doses to organs-at-risk...
June 9, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28601537/trigeminocardiac-reflex-as-the-presentation-of-maxillary-sinus-adenocarcinoma
#7
Jason M Lunt, Ahmad Al-Taee, Rachna Rawal, Fred R Buckhold
The trigeminocardiac reflex is a brainstem reflex that manifests as sudden hemodynamic dysfunction including bradycardia, hypotension, hypopnea, and gastric hypermotility due to mechanical stimulation of the trigeminal nerve. Here, the trigeminocardiac reflex was part of the initial patient presentation that led to the diagnosis of maxillary adenocarcinoma. A 54-year-old male presented to the emergency department with a two-month history of right upper jaw pain. Vital signs included blood pressure of 68/48 mmHg, heart rate of 55, and oxygen saturation of 85%...
June 7, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28590042/changes-in-arrhythmogenic-properties-and-five-year-prognosis-after-carbon-ion-radiotherapy-in-patients-with-mediastinum-cancer
#8
Mari Amino, Koichiro Yoshioka, Makiyoshi Shima, Tohru Okada, Mio Nakajima, Yoshiya Furusawa, Shigetaka Kanda, Sadaki Inokuchi, Teruhisa Tanabe, Yuji Ikari, Tadashi Kamada
INTRODUCTION: Carbon-ion irradiation of rabbit hearts has improved left ventricular conduction abnormalities through upregulation of gap junctions. However, to date, there has been no investigation on the effect of carbon-ion irradiation on electrophysiological properties in human. We investigated this effect in patients with mediastinum extra-cardiac cancer treated with carbon-ion radiotherapy that included irradiating the heart. METHODS AND RESULTS: In April-December 2009, eight patients were prospectively enrolled (including two male, aged 72...
June 7, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28583397/long-term-cardiovascular-health-in-adult-cancer-survivors
#9
REVIEW
W R Naaktgeboren, M Linschoten, A de Graeff, A V Rhenen, M J Cramer, F W Asselbergs, A H E M Maas, A J Teske
The number of cancer survivors has tremendously increased over the past decades as a result of aging of the population and improvements in early cancer detection and treatment. Ongoing successes in cancer treatment are expected to result in a further increase in the number of long-term survivors. However, cancer treatment can have detrimental cardiovascular side-effects that impact morbidity and mortality, reducing quality of life in cancer survivors. The spectrum of radiotherapy- and chemotherapy-induced cardiovascular disease is broad, varying from subclinical valvular dysfunction to overt congestive heart failure, and such effects may not be apparent for more than twenty years after the initial cancer treatment...
May 21, 2017: Maturitas
https://www.readbyqxmd.com/read/28582898/dosimetric-comparisons-of-imrt-planning-using-mco-and-dmpo-techniques
#10
Xiongfei Liao, Jinyi Lang, Ningshan Li, Pei Wang, Jie Li, Jack Yang, Yazheng Chen
The goal of this study was to evaluate the use of multi-criteria optimization (MCO) in the planning and optimization of intensity-modulated radiotherapy (IMRT). Twenty (20) IMRT patients (ten (10) with prostate cancer and ten (10) with lung cancer) were randomly selected. The treatment plans for these patients were designed using direct machine parameter optimization (DMPO). Based on these plans, new plans were designed using multi-criteria optimization (MCO), keeping the optimization objectives and constraints unchanged...
May 19, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28565843/inhibition-of-centrosomal-protein-164-sensitizes-rhabdomyosarcoma-cells-to-radiotherapy
#11
Jianzhou Liu, Zhiju Wang, Xiaofeng Li, Xu Zhang, Chaoji Zhang
Rhabdomyosarcoma is the second most common malignant tumor of the heart in infants and children and cannot often be resected completely. Chemotherapy and radiotherapy have a critical role in relieving symptoms and prolonging survival; therefore, enhancing the sensitivity of rhabdomyosarcoma to radiotherapy is an important area of investigation in order to improve the prognosis of patients. It has been reported that centrosomal protein 164 (CEP164) has a key role in the DNA damage-activated signaling cascade...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28550173/experimental-cardiac-radiation-exposure-induces-ventricular-diastolic-dysfunction-with-preserved-ejection-fraction
#12
Hirofumi Saiki, Gilles Moulay, Adam J Guenzel, Weibin Liu, Teresa Decklever, Kelly Classic, Linh Pham, Horng H Chen, John C Burnett, Stephen J Russell, Margaret M Redfield
BACKGROUND: Breast cancer radiotherapy increases the risk of heart failure (HF) with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radio-resistant but radiation specifically affects coronary microvascular endothelial cells with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28549483/whole-breast-and-regional-nodal-irradiation-in-prone-versus-supine-position-in-left-sided-breast-cancer
#13
Pieter Deseyne, Bruno Speleers, Wilfried De Neve, Bert Boute, Leen Paelinck, Tom Van Hoof, Joris Van de Velde, Annick Van Greveling, Chris Monten, Giselle Post, Herman Depypere, Liv Veldeman
BACKGROUND: Prone whole breast irradiation (WBI) leads to reduced heart and lung doses in breast cancer patients receiving adjuvant radiotherapy. In this feasibility trial, we investigated the prone position for whole breast + lymph node irradiation (WB + LNI). METHODS: A new support device was developed for optimal target coverage, on which patients are positioned in a position resembling a phase from the crawl swimming technique (prone crawl position)...
May 26, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28540630/surgery-for-malignant-lesions-of-the-chest-which-extensively-involved-the-mediastinum-lung-and-heart
#14
REVIEW
Yugo Tanaka, Daisuke Hokka, Hiroyuki Ogawa, Nahoko Shimizu, Takeshi Inoue, Hiroshi Tanaka, Yutaka Okita, Yoshimasa Maniwa
OBJECTIVE: Radical resection for thoracic malignancies that invade the great vessels or heart structure is an uncommon, high-risk operation. To help surgeons determine therapeutic strategy, we reviewed the patient characteristics and outcomes of combined thoracic and cardiovascular surgery for thoracic malignancies. METHODS: Surgical resections of lung cancer, mediastinal tumor and pulmonary artery sarcoma invading great vessels or heart structures were reviewed from the literature...
May 24, 2017: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28529208/long-term-cardiovascular-risk-after-radiotherapy-in-women-with-breast-cancer
#15
REVIEW
Yun-Jiu Cheng, Xiao-Ying Nie, Cheng-Cheng Ji, Xiao-Xiong Lin, Li-Juan Liu, Xu-Miao Chen, Hao Yao, Su-Hua Wu
BACKGROUND: Radiotherapy for breast cancer often involves some incidental exposure of the heart to ionizing radiation. The effect of this exposure on the subsequent risk of heart disease is uncertain. We performed a meta-analysis to investigate the link between radiotherapy and long-term cardiovascular morbidity and mortality in patients with breast cancer. METHODS AND RESULTS: We performed a literature search using MEDLINE (January 1966 to January 2015) and EMBASE (January 1980 to January 2015) with no restrictions...
May 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28508834/a-dosimetric-analysis-of-cardiac-dose-with-or-without-active-breath-coordinator-moderate-deep-inspiratory-breath-hold-in-left-sided-breast-cancer-radiotherapy
#16
Beena Kunheri, Sanketh Kotne, Sneha S Nair, Dinesh Makuny
BACKGROUND AND AIM: Cardiac toxicity is a major concern for left breast tangential field irradiation. The left ventricle and left anterior descending (LAD) artery are suggested to be radiosensitive and radiation to these structures leads to late lethal cardiotoxicity. Moderate deep inspiration breath hold (mDIBH) during radiation treatment delivery helps in reducing the cardiac dose. This study compares dosimetric parameters of heart with and without active breath coordinator (ABC) mDIBH during tangential field breast cancer radiation...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28508833/radiation-induced-non-targeted-effect-in-vivo-evaluation-of-cyclooygenase-2-and-endothelin-1-gene-expression-in-rat-heart-tissues
#17
Reza Fardid, Masoud Najafi, Ashkan Salajegheh, Elahe Kazemi, Abolhasan Rezaeyan
AIM: In this study, we investigated expression levels of cyclooxygenase-2 (COX-2) and endothelin-1 (ET-1) genes after pelvis and heart irradiation in a rat model. These factors are involved in heart diseases (HDs). MATERIALS AND METHODS: We used seven groups, including two groups of pelvic irradiation, two groups of whole body irradiation, two groups of heart irradiation, and one control nonirradiated group. Pelvis irradiations were conducted at a 2 cm × 2 cm in the pelvis area...
January 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28507459/spironolactone-ameliorates-the-cardiovascular-toxicity-induced-by-concomitant-trastuzumab-and-thoracic-radiotherapy
#18
Guler Yavas, Esin Celik, Cagdas Yavas, Cagdas Elsurer, Rengin Elsurer Afsar
AIM: We aimed to evaluate impact of spironolactone (S) on cardiovascular toxicity of concomitant use of radiotherapy (RT) and trastuzumab (T). BACKGROUND: S, an aldosterone receptor antagonist, is known to ameliorate the cardiac damage. S ameliorates anthracycline -induced cardiotoxicity, there is no data regarding to effect of S on both T and radiation-induced cardiotoxicity. MATERIALS/METHODS: Eighty rats were divided into eight groups: group (G) 1 was defined as control group...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28502653/heart-sparing-radiotherapy-in-patients-with-breast-cancer-what-are-the-techniques-used-in-the-clinical-routine-a-pattern-of-practice-survey-in-the-german-speaking-countries
#19
Marciana-Nona Duma, Stefan Münch, Markus Oechsner, Stephanie E Combs
The aim of this study was to understand the practice of care in German-speaking countries with regard to heart-sparing radiotherapy techniques. Between August 2015 and September 2015, an e-mail/fax-based survey was sent to radiation oncology departments in Germany, Austria, and the German-speaking Switzerland. The questionnaire was divided into 3 chapters: a general chapter on the department, a chapter specific for heart-sparing techniques in patients with breast cancer, and a third chapter on personal beliefs on the topic of heart sparing in patients with breast cancer...
May 11, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28499658/-radiotherapy-volume-delineation-based-on-18-f-fluorodeoxyglucose-positron-emission-tomography-for-locally-advanced-or-inoperable-oesophageal-cancer
#20
J Encaoua, R Abgral, C Leleu, O El Kabbaj, P Caradec, D Bourhis, O Pradier, U Schick
PURPOSE: To study the impact on radiotherapy planning of an automatically segmented target volume delineation based on ((18)F)-fluorodeoxy-D-glucose (FDG)-hybrid positron emission tomography-computed tomography (PET-CT) compared to a manually delineation based on computed tomography (CT) in oesophageal carcinoma patients. METHODS AND MATERIALS: Fifty-eight patients diagnosed with oesophageal cancer between September 2009 and November 2014 were included. The majority had squamous cell carcinoma (84...
May 9, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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