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Lesley De Pietri, Marcello Bianchini, Gianluca Rompianesi, Elisabetta Bertellini, Bruno Begliomini
AIM: To describe the thromboelastography (TEG) "reference" values within a population of liver transplant (LT) candidates that underline the differences from healthy patients. METHODS: Between 2000 and 2013, 261 liver transplant patients with a model for end-stage liver disease (MELD) score between 15 and 40 were studied. In particular the adult patients (aged 18-70 years) underwent to a first LT with a MELD score between 15 and 40 were included, while all patients with acute liver failure, congenital bleeding disorders, and anticoagulant and/or antiplatelet drug use were excluded...
September 24, 2016: World Journal of Transplantation
Christos Tapeinos, Eleni K Efthimiadou, Nikos Boukos, George Kordas
A versatile drug delivery carrier that responds to external stimuli was synthesized via the emulsion polymerization process. This simple two-step process was carried out by using Poly (Methyl Methacrylate) as a soft template and a series of monomers, with desired properties, as coating monomers. It is noteworthy that during shell fabrication (2nd step) an inner cavity is created inside the nanocontainers that can be used as a host for small drug molecules. The thermo-, pH- and redox sensitive monomers used in the coating procedure were Dimethyl Amino Ethyl Methacrylate (DMAEMA), Acrylic Acid (AA) and N,N'-(disulfanediylbis(ethane-2,1-diyl))bis(2-methylacrylamide) (Disulfide or DS), respectively...
August 20, 2016: Colloids and Surfaces. B, Biointerfaces
Antonio Neme, Sabine Seuter, Carsten Carlberg
CCCTC-binding factor (CTCF) is a transcription factor being involved in 3D chromatin organization and displays a highly conserved genome-wide binding pattern. In this study, we report the cistrome of CTCF in THP-1 human monocytes and confirm that from the 40,078 CTCF binding sites nearly 85% are identical with those found in K562 monocytes. Quadruplicate chromatin immunoprecipitation sequencing (ChIP-seq) demonstrated that at 2130 loci the association strenght of CTCF with genomic DNA was significantly (p<0...
August 25, 2016: Biochimica et Biophysica Acta
Jose L Revuelta, Ruben M Buey, Rodrigo Ledesma-Amaro, Erick J Vandamme
Vitamins and related compounds, such as provitamins, biopigments and antioxidants, belong to those few chemicals that appeal in a positive way to most people. These terms sound synonymous to vitality, good health and mental strenght, even to the layman. Everyone of us needs his/her daily intake of (pro)vitamins and antioxidants, normally provided by a balanced and varied diet. However, current food habits or preferences, food availabilities, as well as food processing, preservation or cooking methodologies and technologies, do not always assure a sufficient balanced natural daily (pro)vitamin supply to a healthy individual, and even more so for a stressed or sick human being...
September 2016: Microbial Biotechnology
Serdar Yuksel, M Akif Guleç, M Zeki Gultekin, Oktay Adanır, Aysel Caglar, Ozan Beytemur, B Onur Küçükyıldırım, Ali Avcı, Cansu Subaşı, Çiğdem İnci, Erdal Karaoz
INTRODUCTION: This study aims to histopathologically, biomechanically, and immunohistochemically compare the fourth-week efficiencies of local platelet-rich plasma (PRP) and bone marrow-derived mesenchymal stem cell (rBM-MSC) treatments of the Achilles tendon ruptures created surgically in rats. MATERIALS AND METHODS: The study included 35 12-month-old male Sprague Dawley rats, with an average weight of 400-500 g. Five rats were used as donors for MSC and PRP, and 30 rats were separated into MSC, PRP, and control groups (n = 10)...
September 2016: Connective Tissue Research
Mattia Filanti, Chiara Carubbi, Nicolandrea Del Piccolo, Nicola Rani, Alessandro Mazzotta, Dante Dallari
AIM: The purpose of the study was to present our arthroscopic surgical technique and the results in patient with pain after a hip replacement. METHODS: Between November 2009 and September 2011, 35 patients with groin pain after total hip arthroplasty (THA) were treated arthroscopically. The patients underwent a preoperative examination consisting in careful history, physical examination, laboratory evaluation, diagnostic evaluation using x-rays and pelvis CT scans...
May 14, 2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Marco Jacopetti, Andrea Pasquini, Cosimo Costantino
BackgroundThe anterior cruciate ligament (ACL) rupture accounting for about 50% of all knee ligament injuries. The rehabilitation program requires a long time to rebuild muscle strength and to reestablish joint mobility and neuromuscular control. The purpose of the study is to evaluate the muscle strength recovery in athletes with ACL reconstruction. MethodsWe enrolled soccer atlethes, with isolated anterior cruciate ligament rupture treated with bone-patellar tendon-bone autograft artroscopic reconstruction...
2016: Acta Bio-medica: Atenei Parmensis
Luiz Garcia Mandarano-Filho, Débora Schalge Campioto, Márcio Takey Bezuti, Nilton Mazzer, Cláudio Henrique Barbieri
OBJECTIVE: : To evaluate functional outcomes of patients submit-ted to proximal row carpectomy for the treatment of wrist arthri-tis. METHODS: : This is a retrospective study using wrist motion and grip strenght of patients diagnosed with Kienböck disease and scaphoid non-union surgically treated by this technique. RESULTS: : Eleven patients with 2-year follow-up were evaluated. Wrist motion (flexion, extension and ulnar deviation) and grip strength were significantly better from preoperative values...
November 2015: Acta Ortopedica Brasileira
F Franceschi, B Feregalli, S Togni, U Cornelli, L Giacomelli, R Eggenhoffner, G Belcaro
OBJECTIVE: Curcumin is known to interrupt pro-inflammatory signalling and increases anti-oxidant protection, thus inhibiting the expression of inflammatory cytokines and the expression and function of inducible inflammatory enzymes. Together, these effects contribute to limit the onset and the progression of sarcopenia, due to the major role played by inflammation in the pathophysiology of this disease. This registry study evaluates the effects of Meriva® supplementation in otherwise healthy elderly subjects...
2016: European Review for Medical and Pharmacological Sciences
Daniel Antonio De Luis, Olatz Izaola, Pablo Bachiller, Jose Perez Castrillon
AIM: the aim of our study was to investigate the effect on strenght and quality of life of an enhanced specific enteral formula with HMBD and vitamin D in elderly patients. METHODS: we conducted an open-label study. General assessment of nutritional status included measurements of body weight, height, body mass index (kg/m2) and bioimpedance. Handgrrip strength was measured by dynamometry. QOL (quality of life) was assessed using the well validated SF 36 questonnaire...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Lajos Simon, Emese Kovács
The present review focuses on the generally accepted and applied community psychiatry based models of psycho-social rehabilitation. The basics of the Strenghts model and the Recovery based model are introduced in this paper. Both models can be assisted by art therapy in various ways. The forms and the therapeutic factors of art therapy are also discussed, as well as the effects of the creating experience during the art therapy sessions. The authors introduce the good practice of the Moravcsik Foundation with highlights in two special areas that are beyond the generally applied art therapy work and representing important support in reaching the goals set during the rehabilitation process...
2015: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
Anthony M-H Ho, John B Holcomb, Calvin S H Ng, Jorge E Zamora, Manoj K Karmakar, Peter W Dion
Traditional transfusion guidelines suggest that fresh frozen plasma (FFP) should be given based on laboratory or clinical evidence of coagulopathy or acute loss of 1 blood volume. This approach tends to result in a significant lag time between the first units of erythrocytes and FFP in trauma requiring massive transfusion. In severe trauma, observational studies have found an association between increased survival and aggressive use of FFP and platelets such that FFP:platelet:erythrocyte ratio approaches 1:1:1 to 2 from the first units of erythrocytes given...
October 2015: American Journal of Emergency Medicine
Maria Taberner-Vallverdú, Mariam Nazir, M Ángeles Sánchez-Garcés, Cosme Gay-Escoda
BACKGROUND: Dry socket is one of the most common complications occurring after the extraction of a permanent tooth, but in spite of its high incidence there is not an established treatment for this condition. OBJECTIVES: Analyze the efficacy of different methods used in the management of dry socket regarding results of pain's relief and alveolar mucosa healing compared to conventional surgical treatment of curettage and saline irrigation. MATERIAL AND METHODS: A Cochrane and PubMed-MEDLINE database search was conducted with the search terms "dry socket", "post-extraction complications", "alvogyl", "alveolar osteitis" and "fibrynolitic alveolitis", individually and next, using the Boolean operator "AND"...
September 2015: Medicina Oral, Patología Oral y Cirugía Bucal
Laura Verónica Henao-Holguín, Vladimir A Basiuk
Nickel(II) complex of 5,14-dihydro-6,8,15,17-tetramethyldibenzo[b,i][1,4,8,11] tetraazacyclotetradecine (NiTMTAA), which can be employed for noncovalent functionalization of carbon nanotubes (CNTs), represents a more complex and interesting case in terms of structure of the resulting nanohybrids, as compared to the related materials functionalized with porphyrins and phthalocyanines. Due to its saddle shape, the NiTMTAA molecule adsorbed can adopt different, energetically non-equivalent orientations with respect to CNT, depending on whether CH3 or C6H4 groups contact the latter...
June 2015: Journal of Molecular Modeling
Jatupol Junthip, Nicolas Tabary, Laurent Leclercq, Bernard Martel
A polyelectrolyte multilayer film (PEM) based on cationic and anionic β-cyclodextrin polyelectrolytes was coated onto a textile substrate for future drug delivery purposes. We firstly synthesized a novel cationic β-cyclodextrin polymer (polyEPG-CD) by crosslinking β-cyclodextrin (βCD) with epichlorohydrin (EP) under basic conditions, in the presence of glycidyltrimetrylammonium chloride (GTMAC) as cationizing group. The influence of preparation conditions has been investigated in order to preferably obtain a water soluble fraction whose charge density and molecular weights were optimal for the layer-by-layer (LbL) deposition process...
August 1, 2015: Carbohydrate Polymers
Andreas Vigelsø, Martin Gram, Caroline Wiuff, Jesper L Andersen, Jørn W Helge, Flemming Dela
OBJECTIVE: To determine the effect of aerobic retraining as rehabilitation after short-term leg immobilization on leg strength, leg work capacity, leg lean mass, leg muscle fibre type composition and leg capillary supply, in young and older men.Subjects and design: Seventeen young (23 ± 1 years) and 15 older (68 ± 1 [standard error of the mean; SEM] years) men had one leg immobilized for 2 weeks, followed by 6 weeks' bicycle endurance retraining. METHODS: Maximal voluntary contraction, leg work capacity (Wmax), and leg lean mass by dual energy X-ray absorptiometry were measured at inclusion, after immobilization and after 3 and 6 weeks' retraining...
June 2015: Journal of Rehabilitation Medicine
Juan M García Manso, Teresa Valverde, Luis Arrones, Manuel Navarro-Valdivielso, Estélio H Martin Dantas, Marzo E Da Silva-Grigoletto
BACKGROUND: The aim of this paper was to analyze how the rest between interval repetitions in intra-set training (at maximal isometric loads) could affect the ability to repeat maximal contractions in subjects with different levels of performance and different experience in strength development work. METHODS: Twenty subjects were divided randomly into two different groups depending on their sport characteristics: ten subjects were trained in strength development work (Group Strenght--23...
March 2016: Journal of Sports Medicine and Physical Fitness
Daniel Aggio, Lee Smith, Abi Fisher, Mark Hamer
OBJECTIVE: The aim of this study is to investigate whether mothers' perception of distance from home to green/open spaces is associated with their child's screen time. METHOD: We used mother-reported data from sweep six (2010-2011) of the Growing Up in Scotland study (n=3586 children aged 5.9yrs) to examine associations between walking distance from home to green/open space and screen time (TV viewing time/computer use). Analyses were adjusted for age, sex and other pre-specified covariates, including sport/exercise participation, mental and general health, birth weight, parental socio-economic group (SEG) and smoking status...
January 2015: Preventive Medicine
Eduardo Diogo Gurgel-Filho, Felipe Coelho Lima, Vicente de Paula Aragão Saboia, Tauby de Souza Coutinho-Filho, Aline de Almeida Neves, Emmanuel João Nogueira Leal da Silva
OBJECTIVES: The aim of the present study was to investigate the bond strength of RelyX Unicem (3M) to root canal dentin when used as an endodontic sealer. MATERIALS AND METHODS: Samples of 24 single-rooted teeth were prepared with Gates Glidden drills and K3 files. After that, the roots were randomly assigned to three experimental groups (n = 8) according to the filling material, (1) AH Plus (Dentsply De Trey GmbH)/Gutta-Percha cone; (2) Epiphany SE (Pentron)/Resilon cone; (3) RelyX Unicem/Gutta-Percha cone...
November 2014: Restorative Dentistry & Endodontics
Jadranka Kovacević
AIM: Sclerotherapy is the targeted chemical ablation of varicose veins by intravenous injection of a liquid of foamed sclerosing drug. The treated veins may be intradermal, subcutaneous, and/or transfascial as well as superficial and deep in venous malformations. The aim of this guideline is to give evidence-based recommendations for liquid and foam sclerotherapy. METHODS: This guideline was drafted on behalf of 23 European Phlebological Societies during Guideline Conference on 7-10 May 2012 in Mainz...
October 2014: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
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