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https://www.readbyqxmd.com/read/27904513/relationship-between-visual-status-and-functional-status-and-the-risk-of-falls-in-women-the-rac-ost-pol-study
#1
Wojciech Rokicki, Bogna Drozdzowska, Aleksandra Czekajło, Władysław Grzeszczak, Katarzyna Wiktor, Wojciech Majewski, Wojciech Pluskiewicz
INTRODUCTION: Falls in elderly women producing fractures are a public health problem that could be largely preventable. The aim of this study was to determine the effect of visual impairment on functional status, falls and fractures in women. MATERIAL AND METHODS: We examined 623 women aged ≥ 55 years in order to assess the association between visual status and functional status and the risk of falls and fractures. Distance, near visual acuity, and depth perception were examined...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27894213/factor-solutions-of-the-social-phobia-scale-sps-and-the-social-interaction-anxiety-scale-sias-in-a-swedish-population
#2
Ewa Mörtberg, Lena Reuterskiöld, Maria Tillfors, Tomas Furmark, Lars-Göran Öst
Culturally validated rating scales for social anxiety disorder (SAD) are of significant importance when screening for the disorder, as well as for evaluating treatment efficacy. This study examined construct validity and additional psychometric properties of two commonly used scales, the Social Phobia Scale and the Social Interaction Anxiety Scale, in a clinical SAD population (n = 180) and in a normal population (n = 614) in Sweden. Confirmatory factor analyses of previously reported factor solutions were tested but did not reveal acceptable fit...
November 29, 2016: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/27892833/a-mega-analysis-of-memory-reports-from-eight-peer-reviewed-false-memory-implantation-studies
#3
Alan Scoboria, Kimberley A Wade, D Stephen Lindsay, Tanjeem Azad, Deryn Strange, James Ost, Ira E Hyman
Understanding that suggestive practices can promote false beliefs and false memories for childhood events is important in many settings (e.g., psychotherapeutic, medical, and legal). The generalisability of findings from memory implantation studies has been questioned due to variability in estimates across studies. Such variability is partly due to false memories having been operationalised differently across studies and to differences in memory induction techniques. We explored ways of defining false memory based on memory science and developed a reliable coding system that we applied to reports from eight published implantation studies (N = 423)...
November 28, 2016: Memory
https://www.readbyqxmd.com/read/27870477/ascending-single-dose-double-blind-placebo-controlled-safety-study-of-noribogaine-in-opioid-dependent-patients
#4
Paul Glue, Gavin Cape, Donna Tunnicliff, Michelle Lockhart, Fred Lam, Noelyn Hung, C Tak Hung, Sarah Harland, Jane Devane, R S Crockett, John Howes, Borje Darpo, Meijian Zhou, Holger Weis, Lawrence Friedhoff
Ibogaine is a psychoactive substance that may reduce opioid withdrawal symptoms. This was the first clinical trial of noribogaine, ibogaine's active metabolite, in patients established on methadone opioid substitution therapy (OST). In this randomized, double-blind, placebo-controlled single ascending-dose study, we evaluated the safety, tolerability, and pharmacokinetics of noribogaine in 27 patients seeking to discontinue methadone OST who had been switched to morphine during the previous week. Noribogaine doses were 60, 120, or 180 mg (n = 6/dose level) or matching placebo (n = 3/dose level)...
November 2016: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/27854541/what-exactly-is-a-centrally-located-lung-tumor-results-of-an-on-line-survey
#5
Roberto F Casal, Macarena R Vial, Russell Miller, Lakshmi Mudambi, Horiana B Grosu, George A Eapen, Carlos A Jimenez, Rodolfo C Morice, Lorraine Cornwell, David Ost
RATIONALE: Accurate mediastinal staging is cornerstone in the management of patients with lung cancer. For patients with radiographically normal mediastinum, current lung cancer guidelines recommend invasive mediastinal staging when tumors are centrally located. However, definitions of central tumors are non-specific and there are discrepancies among guidelines (e.g. some use the inner one third of the hemithorax while others use the inner two thirds). OBJECTIVES: To describe the definitions of central tumors used by pulmonologists and thoracic surgeons in their practice...
November 17, 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27846264/hepatitis-c-treatment-uptake-among-patients-who-have-received-opioid-substitution-treatment-a-population-based-study
#6
Håvard Midgard, Jørgen G Bramness, Svetlana Skurtveit, John W Haukeland, Olav Dalgard
BACKGROUND AND AIMS: There is limited data on hepatitis C (HCV) treatment uptake among people who inject drugs including individuals receiving opioid substitution treatment (OST). We aimed to calculate cumulative HCV treatment uptake, estimate annual treatment rates, and identify factors associated with HCV treatment among individuals who have received OST in Norway. METHODS: This observational study was based on linked data from The Norwegian Prescription Database and The Norwegian Surveillance System for Communicable Diseases between 2004 and 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27836521/-does-post-operative-sonographic-position-of-preventive-cervical-cerclage-affect-gestational-age-at-birth
#7
L Melle, C Le Ray, P Delorme, O Anselem, F Goffinet, L Marcellin
OBJECTIVE: To evaluate whether the position of preventive cerclage determined by immediate postoperative transvaginal cervical ultrasound is predictive of preterm birth. METHODS: A single-center retrospective study conducted between 1 August 2007 and 31 December 2015 in a maternity type III who included women carrying out for a single pregnancy and who receive a McDonald preventive cerclage. Measurements of internal os-stitch, stitch-external os and the total length of the cervix were performed during immediate postoperative transvaginal cervical ultrasound...
December 2016: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/27835933/experiences-of-the-return-to-work-process-after-stroke-while-participating-in-a-person-centred-rehabilitation-programme
#8
Annika Öst Nilsson, Gunilla Eriksson, Ulla Johansson, Therese Hellman
BACKGROUND: In Sweden, less than 50% of those getting stroke in working age return to work (RTW). Effective rehabilitation programmes need to be developed and therapeutic aspects understood. AIM: To explore and describe how persons with stroke experience their RTW process while participating in a person-centred rehabilitation programme focusing on RTW. MATERIALS AND METHODS: Seven persons with mild or moderate stroke were interviewed twice during the intervention in the vocational training phase using semi-structured interviews...
November 11, 2016: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/27834915/opioid-substitution-treatment-planning-in-a-disaster-context-perspectives-from-emergency-management-and-health-professionals-in-aotearoa-new-zealand
#9
Denise Blake, Antonia Lyons
Opioid Substitution Treatment (OST) is a harm reduction strategy enabling opiate consumers to avoid withdrawal symptoms and maintain health and wellbeing. Some research shows that within a disaster context service disruptions and infrastructure damage affect OST services, including problems with accessibility, dosing, and scripts. Currently little is known about planning for OST in the reduction and response phases of a disaster. This study aimed to identify the views of three professional groups working in Aotearoa/New Zealand about OST provision following a disaster...
November 10, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27832892/the-importance-of-negative-studies-autofluorescence-bronchoscopy-for-lung-cancer-screening
#10
EDITORIAL
David E Ost
No abstract text is available yet for this article.
November 2016: Chest
https://www.readbyqxmd.com/read/27827326/cutting-the-prehospital-on-scene-time-of-stroke-thrombolysis-in-helsinki-a-prospective-interventional-study
#11
Tuukka Puolakka, Markku Kuisma, Sami Länkimäki, Jyrki Puolakka, Juhana Hallikainen, Kirsi Rantanen, Perttu J Lindsberg
BACKGROUND AND PURPOSE: Significant portion of the prehospital delay consists of minutes spent on the scene with the patient. We implemented a training program for the emergency medical services personnel with the aim to optimize the on-scene time (OST) and to study the impact of different elements of prehospital practice to the OST duration. METHODS: In this prospective interventional study, key operational emergency medical service performance variables were analyzed from all thrombolysis candidates transported to the Helsinki University Hospital emergency department...
November 8, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27819752/a-prospective-randomized-controlled-multicentre-trial-comparing-intravesical-dmso-and-chondro%C3%A3-tin-sulphate-2-for-painful-bladder-syndrome-interstitial-cystitis
#12
Manuela Tutolo, Enrico Ammirati, Giulia Castagna, Katrien Klockaerts, Hendrik Plancke, Dieter Ost, Frank Van der Aa, Dirk De Ridder
OBJECTIVE: To compare effectiveness of intravesical chondroïtin sulphate (CS) 2% and dimethyl sulphoxide (DMSO) 50% in patients with painful bladder syndrome/intersti¬tial cystitis (PBS/IC). MATERIALS AND METHODS: Patients were randomized to receive either 6 weekly instil¬lations of CS 2% or 50% DMSO. Primary endpoint was difference in proportion of patients achieving score 6 (moderately improved) or 7 (markedly improved) in both groups using the Global Response Assessment (GRA) scale...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27819296/serum-neurofilament-light-protein-predicts-clinical-outcome-in-traumatic-brain-injury
#13
Pashtun Shahim, Magnus Gren, Victor Liman, Ulf Andreasson, Niklas Norgren, Yelverton Tegner, Niklas Mattsson, Niels Andreasen, Martin Öst, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow
Axonal white matter injury is believed to be a major determinant of adverse outcomes following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament light protein (NF-L), a protein found in long white-matter axons, in blood samples, may serve as a suitable biomarker for neuronal damage in TBI patients. To test our hypotheses, we designed a study in two parts: i) we developed an immunoassay based on Single molecule array technology for quantification of NF-L in blood, and ii) in a proof-of-concept study, we tested our newly developed method on serial serum samples from severe TBI (sTBI) patients (n = 72) and controls (n = 35)...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27814779/speaking-up-using-ostes-to-understand-how-medical-students-address-professionalism-lapses
#14
Constance R Tucker, Beth A Choby, Andrew Moore, Robert Scott Parker, Benjamin R Zambetti, Sarah Naids, Jillian Scott, Jennifer Loome, Sierra Gaffney
BACKGROUND: Objective-structured teaching encounters (OSTEs) are used across many disciplines to assess teaching ability. The OSTE detailed in this paper assesses 191 fourth-year medical students' (M4) ability to identify and address lapses in professionalism based on Association of American Medical Colleges' professionalism competencies. The research questions addressed are How frequently do M4s address professionalism lapses observed during an OSTE? What factors influence whether M4s provide feedback when they observe professionalism lapses in an OSTE? METHODS: Standardized patients (SPs) and standardized learners (SLs) were recruited and trained to participate in a standardized encounter with specific cognitive, social, and behavioral errors, including professionalism lapses...
2016: Medical Education Online
https://www.readbyqxmd.com/read/27808266/integrative-omics-connects-n-glycoproteome-wide-alterations-with-pathways-and-regulatory-events-in-induced-pluripotent-stem-cells
#15
Putty-Reddy Sudhir, Madireddy Pavana Kumari, Wei-Ting Hsu, Chein-Hung Chen, Hung-Chih Kuo, Chung-Hsuan Chen
Molecular-level differences ranging from genomes to proteomes, but not N-glycoproteomes, between human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs) have been assessed to gain insights into cell reprogramming and induced pluripotency. Our multiplexed quantitative N-glycoproteomics study identified altered N-glycoproteins that significantly regulate cell adhesion processes in hiPSCs compared to hESCs. The integrative proteomics and functional network analyses of the altered N-glycoproteins revealed their significant interactions with known PluriNet (pluripotency-associated network) proteins...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793654/transcutaneous-electrical-nerve-stimulation-of-the-foot-results-of-a-novel-at-home-noninvasive-treatment-for-nocturnal-enuresis-in-children
#16
Matthew C Ferroni, Rajeev Chaudhry, Bing Shen, Christopher J Chermansky, Glenn M Cannon, Francis X Schneck, Michael C Ost, Changfeng Tai, Heidi A Stephany
OBJECTIVE: To evaluate the effect of a novel at-home approach to electrical foot stimulation of peripheral tibial nerve branches on the frequency of nocturnal enuresis episodes in children. MATERIALS AND METHODS: Children aged 5 to 18 having 2 or more bedwetting episodes per week for at least 3 consecutive months were eligible. The study was a total of 6 weeks. Participants completed a baseline nighttime voiding diary during the first 2 weeks. This was followed by 2 weeks of foot stimulation for 60 minutes each night...
October 25, 2016: Urology
https://www.readbyqxmd.com/read/27789682/disrupted-murine-gut-to-human-liver-signaling-alters-bile-acid-homeostasis-in-humanized-mouse-liver-models
#17
Edwin C Y Chow, Holly P Quach, Yueping Zhang, Jason Z Y Wang, David C Evan, Albert P Li, Jose Silva, Rommel G Tirona, Yurong Lai, K Sandy Pang
The humanized liver mouse model is increasingly being exploited for human drug metabolism studies. However, its model stability, inter-communication between human hepatocytes and mouse non-parenchymal cells in liver and murine intestine, and changes in extrahepatic transporter and enzyme expression has not been investigated. We examined these issues in FRGN [Fah(-/-), Rag2(-/-), and IL-2rg(-/-) on NOD background] and chimeric mice: mFRGN, and hFRGN (repopulated with mouse or human hepatocytes, respectively)...
October 27, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27784535/blood-and-feather-concentrations-of-toxic-elements-in-a-baltic-and-an-arctic-seabird-population
#18
Anette A Fenstad, Jan O Bustnes, Syverin Lierhagen, Kristin M Gabrielsen, Markus Öst, Kim Jaatinen, Sveinn A Hanssen, Børge Moe, Bjørn M Jenssen, Åse Krøkje
We report blood and feather concentrations of elements in the Baltic Sea and Arctic population of common eiders (Somateria mollissima). The endangered Baltic Sea population of eiders was demonstrably affected by element pollution in the 1990s. While blood concentrations of Hg were higher in Baltic breeding eiders, blood Se, As and Cd concentrations were higher in Arctic eiders. Blood concentrations of Pb, Cr, Zn and Cu did not differ between the two populations. While blood Pb concentrations had declined in Baltic eiders since the 1990s, Hg concentrations had not declined, and were above concentrations associated with adverse oxidative effects in other bird species...
October 23, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27777766/physical-activity-and-sedentary-behavior-in-belgium-bnfcs2014-design-methods-and-expected-outcomes
#19
Thérésa Lebacq, Cloë Ost, Sarah Bel, Loes Brocatus, Eveline Teppers, Koenraad Cuypers, Jean Tafforeau, Karin A A De Ridder
BACKGROUND: There is strong evidence to indicate that regular moderate intensity physical activity is associated with health benefits. Furthermore, sedentary behavior has been related with an increased risk for all-cause mortality. The accurate measurement of physical activity and sedentary behavior is therefore vital to evaluate their health impact and provide evidence for the development of public health recommendations. This paper describes the methodology used for assessing physical activity and sedentary behavior in the Belgian population in the context of the Belgian National Food Consumption Survey 2014 (BNFCS2014)...
2016: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/27775955/depression-anxiety-and-stress-among-people-with-chronic-hepatitis-c-virus-infection-and-a-history-of-injecting-drug-use-in-new-south-wales-australia
#20
Emmanuel Fortier, Maryam Alavi, Julie Bruneau, Michelle Micallef, Jacinta Perram, Sanjeev Sockalingam, Adrian J Dunlop, Annie C Balcomb, Carolyn A Day, Carla Treloar, Nicky Bath, Paul S Haber, Gregory J Dore, Jason Grebely
OBJECTIVE: The aims of this study were to assess symptoms of depression, anxiety, and stress and associated sociodemographic factors among people living with chronic hepatitis C virus (HCV) infection with a history of injecting drug use and to assess the association between symptoms of depression, anxiety, or stress and HCV treatment intent, specialist assessment, or treatment uptake. METHODS: The Enhancing Treatment for Hepatitis C in Opioid Substitution Settings was an observational cohort study evaluating the provision of HCV assessment and treatment among people with chronic HCV and a history of injecting drug use, recruited from 9 community health centers and opioid substitution therapy (OST) clinics (New South Wales, Australia)...
October 21, 2016: Journal of Addiction Medicine
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