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https://www.readbyqxmd.com/read/29024191/non-specific-pleuritis-in-patients-with-active-malignancy
#1
Erik Vakil, David Ost, Macarena R Vial, John Stewart, Mona G Sarkiss, Rodolfo C Morice, Roberto F Casal, Georgie A Eapen, Horiana B Grosu
BACKGROUND AND OBJECTIVE: Pleuroscopy is the test of choice for patients with suspected malignant pleural effusion and negative cytology. Biopsies negative for malignancy are frequently attributed to non-specific pleuritis, which poses a dilemma in patients with a known active malignancy, raising concern for a false-negative result. Our primary objective was to determine the outcomes of patients with active malignancy who had a non-malignant diagnosis on pleuroscopy. METHODS: Retrospective review of all pleuroscopy cases from January 2005 to January 2015 at our institution was conducted...
October 12, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29019420/what-role-does-stereotactic-ablative-radiotherapy-have-in-advanced-castrate-resistant-prostate-cancer
#2
Ryan Phillips, Piet Ost, Phuoc T Tran
No abstract text is available yet for this article.
October 11, 2017: Future Oncology
https://www.readbyqxmd.com/read/28993419/quantitative-profiling-of-n-linked-glycosylation-machinery-in-yeast-saccharomyces-cerevisiae
#3
Kristina Poljak, Nathalie Selevsek, Elsy Ngwa, Jonas Grossmann, Marie Estelle Losfeld, Markus Aebi
Asparagine-linked glycosylation is a common posttranslational protein modification regulating the structure, stability and function of many proteins. The N-linked glycosylation machinery involves enzymes responsible for the assembly of the lipid-linked oligosaccharide (LLO), which is then transferred to the asparagine residues on the polypeptides by the enzyme oligosaccharyltransferase (OST).  A major goal in the study of protein glycosylation is to establish quantitative methods for the analysis of site-specific extent of glycosylation...
October 9, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28988187/changes-in-uk-ophthalmology-surgical-training-analysis-of-cumulative-surgical-experience-2009-2015
#4
Jeremy Hoffman, Fiona Spencer, Daniel Ezra, Alexander C Day
OBJECTIVE: To investigate changes in the patterns of cumulative surgical experience for ophthalmologists in the UK following the introduction of a new national training scheme. DESIGN: Retrospective review of all surgical training records submitted to the UK Royal College of Ophthalmologists by trainees for the award of Certificate of Completion of Training (CCT) for the period 2009-2015. SETTING: Secondary level care, UK. PARTICIPANTS: 539 trainees achieving CCT over the 7-year study period...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28987019/patterns-of-substance-use-and-mortality-risk-in-a-cohort-of-hard-to-reach-polysubstance-users
#5
Linn Gjersing, Anne Line Bretteville-Jensen
AIMS: To examine the mortality risk in a cohort of "hard-to-reach" polysubstance users and its putative associations with substance use. Specifically, we estimated all-cause mortality risk as a function of individual substance use indicators, and then as a function of their complex, "real-life" patterns as identified through Latent Class Analysis (LCA). DESIGN: Prospective cohort study among street-and low-threshold-service-recruited polysubstance users included between September and November 2013 and followed through the National Cause of Death Registry until 31 October 2015...
October 7, 2017: Addiction
https://www.readbyqxmd.com/read/28972371/enzymatic-generation-of-highly-anticoagulant-bovine-intestinal-heparin
#6
Li Fu, Kevin Li, Daisuke Mori, Makoto Hirakane, Lei Lin, Navdeep Grover, Payel Datta, Yanlei Yu, Jing Zhao, Fuming Zhang, Murat Yalcin, Shaker A Mousa, Jonathan S Dordick, Robert J Linhardt
Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1, -3 and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.
October 3, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28971794/bowel-preparation-prior-to-reconstructive-urologic-surgery-in-pediatric-myelomeningocele-patients
#7
Nicholas J Farber, Rachel B Davis, Gwen M Grimsby, Brian Shinder, Glenn M Cannon, Micah A Jacobs, Michael C Ost, Francis X Schneck, Heidi A Stephany, Patricio C Gargollo, Moira E Dwyer
INTRODUCTION: Mechanical bowel preparation (MBP) has historically been the standard of care for patients undergoing reconstructive urologic surgery, including urinary diversion. To date, several studies have examined the role of mechanical bowel preparation in postoperative outcomes in pediatric patients undergoing augmentation cystoplasty. However, these patient populations have been heterogeneous in nature, with no studies dedicated to examining the role of MBP prior to reconstructive urologic surgery in pediatric patients with myelomenginoceles...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28967504/national-trends-and-predictors-of-organ-sparing-for-invasive-penile-tumors-expanding-the-therapeutic-window
#8
Juan Chipollini, Dominic H Tang, Pranav Sharma, Philippe E Spiess
INTRODUCTION: The purpose of this study was to analyze contemporary trends and predictors in the use of organ-sparing treatment (OST) for low-stage invasive penile tumors as well as to ascertain its impact on overall mortality (OM) in those with high-risk (pT2) disease. PATIENTS AND METHODS: The National Cancer Data Base was queried for patients with clinically nonmetastatic penile cancer and available pathologic tumor (pT) and treatment data from 1998 to 2012. Independent predictors for performance of OST were analyzed...
September 8, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28962604/estimating-the-number-of-people-who-inject-drugs-in-australia
#9
Sarah Larney, Matthew Hickman, Rebecca Guy, Jason Grebely, Gregory J Dore, Richard T Gray, Carolyn A Day, Jo Kimber, Louisa Degenhardt
BACKGROUND: Injecting drug use is associated with considerable morbidity and mortality. Estimates of the size of the population of people who inject drugs are critical to inform service planning and estimate disease burden due to injecting drug use. We aimed to estimate the size of the population of people who inject drugs in Australia. METHODS: We applied a multiplier method which used benchmark data (number of people in opioid substitution therapy (OST) on a snapshot day in 2014) and multiplied it by a factor derived from the prevalence of current OST among people who inject drugs participating in the Australian Needle and Syringe Program Survey in 2014...
September 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28961115/a-survey-of-calibration-methods-for-optical-see-through-head-mounted-displays
#10
Jens Grubert, Yuta Itoh, Kenneth R Moser, J Edward Swan Ii
Optical see-through head-mounted displays (OST HMDs) are a major output medium for Augmented Reality, which have seen significant growth in popularity and usage among the general public due to the growing release of consumer-oriented models, such as the Microsoft Hololens. Unlike Virtual Reality headsets, OST HMDs inherently support the addition of computer-generated graphics directly into the light path between a user's eyes and their view of the physical world. As with most Augmented and Virtual Reality systems, the physical position of an OST HMD is typically determined by an external or embedded 6-Degree-of-Freedom tracking system...
September 28, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28959145/the-use-of-intraoperative-cell-salvage-in-urologic-oncology
#11
Matthew C Ferroni, Andres F Correa, Timothy D Lyon, Benjamin J Davies, Michael C Ost
Intraoperative cell salvage (IOCS) has been used in urologic surgery for over 20 years to manage intraoperative blood loss and effectively minimize the need for allogenic blood transfusion. Concerns about viability of transfused erythrocytes and potential dissemination of malignant cells have been addressed in the urologic literature. We present a comprehensive review of the use of IOCS in urologic oncologic surgery. IOCS has been shown to preserve the integrity of erythrocytes during processing and effectively provides cell filtration to mitigate the risk of tumor dissemination...
2017: Reviews in Urology
https://www.readbyqxmd.com/read/28944996/negative-pressure-wound-therapy-promotes-muscle-derived-stem-cell-osteogenic-differentiation-through-mapk-pathway
#12
Hong Liu, Xun Zheng, Liang Chen, Chao Jian, Xiang Hu, Yong Zhao, Zonghuan Li, Aixi Yu
Negative pressure wound therapy (NPWT) has been revealed to be effective in the treatment of open fractures, although the underlying mechanism is not clear. This article aimed to investigate the effects of NPWT on muscle-derived stem cell (MDSC) osteoblastic differentiation and the related potential mechanism. The cell proliferation rate was substantially increased in NPWT-treated MDSCs in comparison with a static group for 3 days. There was no observable effect on the apoptosis of MDSC treated with NPWT compared with the control group for 3 days...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28943047/editorial-comment
#13
Filip Poelaert, Piet Ost, Nicolaas Lumen
No abstract text is available yet for this article.
September 21, 2017: Urology
https://www.readbyqxmd.com/read/28941292/opioid-and-opioid-substitution-therapy-in-liver-transplant-candidates-a-survey-of-center-policies-and-practices
#14
James N Fleming, Jennifer C Lai, Helen S Te, Adnan Said, Erin Spengler, Shari S Rogal
This national survey sought to determine the practices and policies pertaining to opioid and opioid substitution therapy (OST) use in the selection of liver transplant (LT) candidates. Of 114 centers, 61 (53.5%) responded to the survey, representing 49.2% of the LT volume in 2016. Only 2 programs considered chronic opioid (1 (1.6%)) or OST use (1 (1.6%)) absolute contraindications to transplant, while 63.9% and 37.7% considered either one a relative contraindication, respectively. The majority of programs did not have a written policy on chronic opioid use (73...
September 23, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28938918/combined-high-dose-radiation-and-pazopanib-in-metastatic-renal-cell-carcinoma-a-phase-i-dose-escalation-trial
#15
Katrien De Wolf, Sylvie Rottey, Karim Vermaelen, Karel Decaestecker, Nora Sundahl, Lizzy De Lobel, Els Goetghebeur, Gert De Meerleer, Nicolaas Lumen, Valérie Fonteyne, Daan De Maeseneer, Piet Ost
BACKGROUND: The primary objective was to determine maximum tolerated radiation dose in patients with metastatic renal cell carcinoma on pazopanib treatment. METHODS: Treatment-naïve patients received pazopanib according to standard of care. Stereotactic body radiotherapy (SBRT) was delivered concurrently to the largest metastatic lesion at day 8, 10 and 12. SBRT doses were escalated in 3 dose levels (24 Gy/3, 30 Gy/3 and 36 Gy/3). Dose level was assigned using Time-to-Event Continual Reassessment Method with the target dose-limiting toxicity rate set to 0...
September 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28937479/retinal-vasculitis-and-choroidopathy-in-pediatric-onset-mixed-connective-tissue-disease
#16
Bradley Postlethwaite, Henry G Wynn, Debendra Pattanaik, Shelley Ost, Charles B MacDonald, R Christopher Walton, Seunghyun Kim, Linda K Myers, Monica Brown Lobbins
No abstract text is available yet for this article.
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28935112/a-pipeline-for-studying-and-engineering-single-subunit-oligosaccharyltransferases
#17
Thapakorn Jaroentomeechai, Xiaolu Zheng, Jasmine Hershewe, Jessica C Stark, Michael C Jewett, Matthew P DeLisa
Asparagine-linked (N-linked) protein glycosylation is one of the most abundant types of posttranslational modification, occurring in all domains of life. The central enzyme in N-linked glycosylation is the oligosaccharyltransferase (OST), which catalyzes the covalent attachment of preassembled glycans to specific asparagine residues in target proteins. Whereas in higher eukaryotes the OST is comprised of eight different membrane proteins, of which the catalytic subunit is STT3, in kinetoplastids and prokaryotes the OST is a monomeric enzyme bearing homology to STT3...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28934985/factors-influencing-on-scene-time-in-a-rural-norwegian-helicopter-emergency-medical-service-a-retrospective-observational-study
#18
Øyvind Østerås, Jon-Kenneth Heltne, Bjørn-Christian Vikenes, Jörg Assmus, Guttorm Brattebø
BACKGROUND: Critically ill patients need to be immediately identified, properly managed, and rapidly transported to definitive care. Extensive prehospital times may increase mortality in selected patient groups. The on-scene time is a part of the prehospital interval that can be decreased, as transport times are determined mostly by the distance to the hospital. Identifying factors that affect on-scene time can improve training, protocols, and decision making. Our objectives were to assess on-scene time in the Helicopter Emergency Medical Service (HEMS) in our region and selected factors that may affect it in specific and severe conditions...
September 21, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28928222/single-subunit-oligosaccharyltransferases-of-trypanosoma-brucei-display-different-and-predictable-peptide-acceptor-specificities
#19
Anders A J Jinnelov, Liaqat Ali, Michele Tinti, Michael A J Ferguson
Trypanosoma brucei causes African trypanosomiasis and contains three full-length oligosaccharyltransferase (OST) genes; two of which, TbSTT3A and TbSTT3B, are expressed in the bloodstream form of the parasite. These OSTs have different peptide acceptor and lipid-linked oligosaccharide donor specificities and trypanosomes do not follow many of the canonical rules developed for other eukaryotic N-glycosylation pathways, raising questions as to the basic architecture and detailed function of trypanosome OSTs. Here, we show by blue-native gel electrophoresis and stable isotope labelling in cell culture proteomics that the TbSTT3A and TbSTT3B proteins associate with each other in large complexes that contain no other detectable protein subunits...
September 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28928140/selenoprotein-t-is-a-novel-ost-subunit-that-regulates-upr-signaling-and-hormone-secretion
#20
Abdallah Hamieh, Dorthe Cartier, Houssni Abid, André Calas, Carole Burel, Christine Bucharles, Cedric Jehan, Luca Grumolato, Marc Landry, Patrice Lerouge, Youssef Anouar, Isabelle Lihrmann
Selenoprotein T (SelT) is a recently characterized thioredoxin-like protein whose expression is very high during development, but is confined to endocrine tissues in adulthood where its function is unknown. We report here that SelT is required for adaptation to the stressful conditions of high hormone level production in endocrine cells. Using immunofluorescence and TEM immunogold approaches, we find that SelT is expressed at the endoplasmic reticulum membrane in all hormone-producing pituitary cell types. SelT knockdown in corticotrope cells promotes unfolded protein response (UPR) and ER stress and lowers endoplasmic reticulum-associated protein degradation (ERAD) and hormone production...
September 19, 2017: EMBO Reports
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