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https://www.readbyqxmd.com/read/29231044/a-systematic-review-of-exercise-and-psychosocial-rehabilitation-interventions-to-improve-health-related-outcomes-in-patients-with-bladder-cancer-undergoing-radical-cystectomy
#1
Elke Rammant, Karel Decaestecker, Renée Bultijnck, Nora Sundahl, Piet Ost, Nele S Pauwels, Benedicte Deforche, Ronny Pieters, Valérie Fonteyne
OBJECTIVE: Summarizing the evidence on the effects of pre- and postoperative exercise and psychosocial rehabilitation interventions on patient-reported outcomes (PROs) and physical fitness in bladder cancer patients undergoing radical cystectomy. DATA SOURCES: The Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Web of Science and the Physiotherapy Evidence Database were searched independently by two authors from inception until 10 November 2017...
December 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29229176/use-of-concomitant-androgen-deprivation-therapy-in-patients-treated-with-early-salvage-radiotherapy-for-biochemical-recurrence-after-radical-prostatectomy-long-term-results-from-a-large-multi-institutional-series
#2
Giorgio Gandaglia, Nicola Fossati, R Jeffrey Karnes, Stephen A Boorjian, Michele Colicchia, Alberto Bossi, Thomas Seisen, Cesare Cozzarini, Nadia Di Muzio, Barbara Noris Chiorda, Emanuele Zaffuto, Thomas Wiegel, Shahrokh F Shariat, Gregor Goldner, Steven Joniau, Antonino Battaglia, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hendrick Van Poppel, Francesco Montorsi, Alberto Briganti
BACKGROUND: Hormonal manipulation concomitant to salvage radiotherapy (SRT) given for biochemical recurrence (BCR) after radical prostatectomy (RP) improved outcomes in two randomized trials. However, neither of these studies focused on men treated at low prostate-specific antigen (PSA) levels. OBJECTIVE: To test if the impact of androgen deprivation therapy (ADT) on metastasis in patients undergoing early SRT varies according to prostate cancer (PCa) features. DESIGN, SETTING, AND PARTICIPANTS: A total of 525 patients received SRT at PSA levels ≤2ng/ml...
December 8, 2017: European Urology
https://www.readbyqxmd.com/read/29215637/one-flexible-loop-in-ost-lassos-both-substrates
#3
Shiteshu Shrimal, Natalia A Cherepanova, Reid Gilmore
No abstract text is available yet for this article.
December 7, 2017: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29204843/incidence-and-risk-factors-for-hepatitis-c-virus-infection-among-illicit-drug-users-in-italy
#4
Enea Spada, Giovanni Rezza, Anna Rosa Garbuglia, Flavia Lucia Lombardo, Ornella Zuccaro, Francesca Menniti Ippolito, Elisabetta Cupellaro, Stefania Capone, Maria Rosaria Capobianchi, Alfredo Nicosia, Riccardo Cortese, Antonella Folgori, Alfonso Mele
So far, only three small outdated studies have investigated hepatitis C virus (HCV) incidence and risk factors among illicit drug users (DUs) in Italy. Thus, during 2007-2010, we conducted a prospective cohort study among DUs attending 17 Italian rehabilitation centers serving urban areas. Two hundred eighty-four HCV-uninfected DUs were prospectively followed by interview and anti-HCV antibody and RNA testing every 6 months. Incidence was calculated using the person-years method. Infection predictors were assessed by time-dependent Cox analysis...
December 4, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/29195188/long-term-effectiveness-of-cognitive-behavioral-therapy-for-youth-with-anxiety-disorders
#5
Arne Kodal, Krister Fjermestad, Ingvar Bjelland, Rolf Gjestad, Lars-Göran Öst, Jon F Bjaastad, Bente S M Haugland, Odd E Havik, Einar Heiervang, Gro Janne Wergeland
Cognitive behavioral therapy (CBT) has demonstrated favorable long-term outcomes in youth with anxiety disorders in efficacy trials. However, long-term outcomes of CBT delivered in a community setting are uncertain. This study examined the long-term outcomes of individual (ICBT) and group CBT (GCBT) in youth with anxiety disorders treated in community mental health clinics. A total of 139 youth (mean age at assessment 15.5 years, range 11-21 years) with a principal diagnosis of separation anxiety disorder (SAD), social anxiety disorder (SOP), and/or generalized anxiety disorder (GAD) were evaluated, on average, 3...
November 26, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29194928/clinical-pathway-improves-implementation-of-evidence-based-strategies-for-the-management-of-androgen-deprivation-therapy-induced-side-effects-in-prostate-cancer-patients
#6
Renée Bultijnck, Inge Van de Caveye, Elke Rammant, Sofie Everaert, Nicolaas Lumen, Karel Decaestecker, Valérie Fonteyne, Benedicte Deforche, Piet Ost
OBJECTIVES: To assess the effects of a prostate cancer (PCa) clinical pathway on the implementation of evidence-based strategies for the management of ADT-induced side effects. SUBJECTS/PATIENTS AND METHODS: A clinical pathway was introduced at hospital-level in 2015. The pathway consists out of evidence-based strategies for the management of ADT-induced side effects. All PCa patients receiving ADT for >6 months were eligible to enter the clinical pathway. Data of recommended evidence-based strategies were retrospectively extracted from electronic health records of all eligible patients in the year before (2014) and the year of implementation of the pathway (2015)...
December 1, 2017: BJU International
https://www.readbyqxmd.com/read/29179255/excess-overdose-mortality-immediately-following-transfer-of-patients-and-their-care-as-well-as-after-cessation-of-opioid-substitution-therapy
#7
Karolina M Bogdanowicz, Robert Stewart, Chin-Kuo Chang, Hitesh Shetty, Mizanur Khondoker, Edward Day, Richard D Hayes, John Strang
AIMS: To investigate clustering of all-cause and overdose deaths after a transfer of patients and their care to alternative treatment provider and after the end of opioid substitution therapy (OST) in opioid-dependent individuals in specialist addiction treatment. DESIGN, SETTING AND PARTICIPANTS: Mortality data were identified within a sample of 5,445 patients with opioid use disorder who had received OST treatment between 1st April 2008 and 31st December 2013 from a large mental healthcare provider in United Kingdom...
November 27, 2017: Addiction
https://www.readbyqxmd.com/read/29178580/a-cell-free-platform-for-rapid-synthesis-and-testing-of-active-oligosaccharyltransferases
#8
Jennifer A Schoborg, Jasmine Hershewe, Jessica C Stark, Weston Kightlinger, James E Kath, Thapakorn Jaroentomeechai, Aravind Natarajan, Matthew P DeLisa, Michael C Jewett
Protein glycosylation, or the attachment of sugar moieties (glycans) to proteins, is important for protein stability, activity, and immunogenicity. However, understanding the roles and regulations of site-specific glycosylation events remains a significant challenge due to several technological limitations. These limitations include a lack of available tools for biochemical characterization of enzymes involved in glycosylation. A particular challenge is the synthesis of oligosaccharyltransferases (OSTs), which catalyze the attachment of glycans to specific amino acid residues in target proteins...
November 27, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29161720/development-of-ostqol-a-measure-of-quality-of-life-for-patients-in-opioid-substitution-treatment
#9
Lisa Strada, Gabriele Helga Franke, Bernd Schulte, Jens Reimer, Uwe Verthein
BACKGROUND: Quality of life (QOL) of patients in opioid substitution treatment (OST) is increasingly being addressed in research. However, no disease- or treatment-specific instrument is available to assess the QOL of this target population. The purpose of this project was to develop the first QOL instrument for OST patients. METHODS: Focus groups with 60 OST patients were analyzed using thematic analysis to elicit key QOL themes as perceived by patients. Identified themes were developed into items and refined through pilot testing and cognitive debriefing...
November 21, 2017: European Addiction Research
https://www.readbyqxmd.com/read/29156678/epigenetic-silencing-of-tumor-suppressor-candidate-3-confers-adverse-prognosis-in-early-colorectal-cancer
#10
Elke Burgermeister, Patrick Höde, Johannes Betge, Tobias Gutting, Andreas Merkel, Wen Wu, Marc Tänzer, Maximilian Mossner, Daniel Nowak, Julia Magdeburg, Felix Rückert, Carsten Sticht, Katja Breitkopf-Heinlein, Nadine Schulte, Nicolai Härtel, Sebastian Belle, Stefan Post, Timo Gaiser, Barbara Ingold Heppner, Hans-Michael Behrens, Christoph Röcken, Matthias P A Ebert
Colorectal cancer (CRC) is a biologically and clinically heterogeneous disease. Even though many recurrent genomic alterations have been identified that may characterize distinct subgroups, their biological impact and clinical significance as prognostic indicators remain to be defined. The tumor suppressor candidate-3 (TUSC3/N33) locates to a genomic region frequently deleted or silenced in cancers. TUSC3 is a subunit of the oligosaccharyltransferase (OST) complex at the endoplasmic reticulum (ER) which catalyzes bulk N-glycosylation of membrane and secretory proteins...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154793/trends-in-urologic-indications-for-pediatric-renal-transplantation-over-a-27-year-period-unos-database
#11
Pankaj Dangle, Utsav Bansal, Rajeev Chaudhry, Glenn M Cannon, Francis X Schneck, Michael C Ost
OBJECTIVE: To elucidate the trends in urological causes for renal transplant in the pediatric population using a national database. Little is known about the specific pediatric urologic conditions and resultant trends that precede renal transplantation. MATERIAL AND METHODS: We reviewed the United Network for Organ Sharing (UNOS) database for pediatric patients (<18 years old) who underwent renal transplantation from January 1988- September 2015. We included those patients who received a renal transplant due to a urologic condition...
November 14, 2017: Urology
https://www.readbyqxmd.com/read/29154759/radiation-exposure-in-pediatric-urology-patients-how-to-adhere-to%C3%A2-alara
#12
EDITORIAL
Michael C Ost
No abstract text is available yet for this article.
November 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29146527/osthole-attenuates-right-ventricular-remodeling-via-decreased-myocardial-apoptosis-and-inflammation-in-monocrotaline-induced-rats
#13
Yeli Li, Yiqi Li, Fuguo Shi, Lina Wang, Lisheng Li, Danli Yang
Osthole (Ost) is a coumarin that exhibits wide pharmacological effects in the cardiovascular system. However, whether Ost can inhibit apoptosis and inflammation in right ventricle (RV) cardiomyocytes and prevent RV remodeling is not clear. This study was designed to investigate the effect of Ost on RV remodeling and the underlying mechanism. By applying a monocrotaline (MCT)-induced rat model, the effect of Ost on RV remodeling was investigated. Rats were given a single dose of MCT (50mg⁄kg) subcutaneously (s...
November 13, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29143977/manuscript-title-motivation-and-treatment-credibility-predict-alliance-in-cognitive-behavioral-treatment-for-youth-with-anxiety-disorders-in-community-clinics
#14
K W Fjermestad, M D Lerner, B D McLeod, G J H Wergeland, B S M Haugland, O E Havik, L-G Öst, W K Silverman
OBJECTIVE: We examined whether motivation and treatment credibility predicted alliance in a 10-session cognitive behavioral treatment delivered in community clinics for youth anxiety disorders. METHOD: Ninety-one clinic-referred youths (meanage  = 11.4 years, standard deviation = 2.1, range 8-15 years, 49.5% boys) with anxiety disorders-rated treatment motivation at pretreatment and perceived treatment credibility after session 1. Youths and therapists (YT) rated alliance after session 3 (early) and session 7 (late)...
November 16, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29135846/bringing-the-ohiohealth-nursing-strategic-plan-to-life-with-the-aone-care-innovation-and-transformation-program
#15
Kelly Dials, Lisa Gossett, Lindsey Osting, David Rutherford, Janet Stifter
Contemporary CNOs are committed to developing the next generation of nurse leaders. At OhioHealth, the nursing strategic vision includes the belief that every nurse will be a leader in improving health across the care continuum. In 2016, the OhioHealth System partnered with AONE to participate in the Care Innovation and Transformation program resulting in bedside nurses living this strategic vision and creating positive changes in quality, safety, and satisfaction for patients and families.
December 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29113801/producing-a-glycosylating-escherichia-coli-cell-factory-the-placement-of-the-bacterial-oligosaccharyl-transferase-pglb-onto-the-genome
#16
Benjamin Strutton, Stephen R P Jaffé, Jagroop Pandhal, Phillip C Wright
Although Escherichia coli has been engineered to perform N-glycosylation of recombinant proteins, an optimal glycosylating strain has not been created. By inserting a codon optimised Campylobacter oligosaccharyltransferase onto the E. coli chromosome, we created a glycoprotein platform strain, where the target glycoprotein, sugar synthesis and glycosyltransferase enzymes, can be inserted using expression vectors to produce the desired homogenous glycoform. To assess the functionality and glycoprotein producing capacity of the chromosomally based OST, a combined Western blot and parallel reaction monitoring mass spectrometry approach was applied, with absolute quantification of glycoprotein...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29101841/the-mediating-role-of-changes-in-harm-beliefs-and-coping-efficacy-in-youth-with-specific-phobias
#17
Thomas H Ollendick, Sarah M Ryan, Nicole N Capriola-Hall, Lena Reuterskiöld, Lars-Göran Öst
Individuals with specific phobias (SPs) often experience catastrophic cognitions and compromised efficacy regarding their ability to cope when in the presence of the phobic object/situation. In the current study, 165 children (7-16 years; 62% male) received either One Session Treatment or Educational Support Therapy for their SP. The children identified their feared belief and rated "how bad" it was, "how likely" it was to occur, and their ability to cope if it did occur. All of these ratings were reduced from pre-treatment to 6-month follow-up, across both treatment conditions...
October 18, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29095133/stepped-care-in-primary-care-guided-self-help-and-face-to-face-cognitive-behavioural-therapy-for-common-mental-disorders-a-randomized-controlled-trial
#18
Sigrid Salomonsson, Fredrik Santoft, Elin Lindsäter, Kersti Ejeby, Brjánn Ljótsson, Lars-Göran Öst, Martin Ingvar, Mats Lekander, Erik Hedman-Lagerlöf
BACKGROUND: Common mental disorders (CMD) cause large suffering and high societal costs. Cognitive behavioural therapy (CBT) can effectively treat CMD, but access to treatment is insufficient. Guided self-help (GSH) CBT, has shown effects comparable with face-to-face CBT. However, not all patients respond to GSH, and stepping up non-responders to face-to-face CBT, could yield larger response rates. The aim was to test a stepped care model for CMD in primary care by first evaluating the effects of GSH-CBT and secondly, for non-responders, evaluating the additional effect of face-to-face CBT...
November 2, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29094773/availability-of-prostate-cancer-exercise-rehabilitation-resources-and-practice-patterns-in-belgium-results-of-a-cross-sectional-study
#19
R Bultijnck, B Van Ruymbeke, S Everaert, H Bagué, E Rammant, S Rimbaut, V Fonteyne, N Lumen, K Decaestecker, P Ost
Exercise is recommended for prostate cancer (PCa) patients treated with androgen deprivation therapy. The goal of the study was to assess the availability of hospital-based rehabilitation resources and national practice patterns for PCa in Belgium. A questionnaire was conducted with rehabilitation physical therapists in all Belgian hospital with urology and rehabilitation departments. Practice patterns were compared with the American College of Sports Medicine guidelines. PCa prevalence data were obtained from the Belgian Cancer Registry and attitude of physicians towards physical activity was documented...
November 2, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/29093816/the-added-value-of-food-frequency-questionnaire-ffq-information-to-estimate-the-usual-food-intake-based-on-repeated-24-hour-recalls
#20
Cloë Ost, Karin A A De Ridder, Jean Tafforeau, Herman Van Oyen
Background: Statistical methods to model the usual dietary intake of foods in a population generally ignore the additional information on the never-consumers. The objective of this study is to determine the added value of Food Frequency Questionnaire (FFQ) data allowing distinguishing the never-consumers from the non-consumers while modeling the usual intake distribution. Methods: Three food items with a different proportion of never-consumers were selected from the database of the Belgian food consumption survey of 2004 (N = 3200)...
2017: Archives of Public Health, Archives Belges de Santé Publique
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