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https://www.readbyqxmd.com/read/29672985/the-impact-of-buprenorphine-and-methadone-on-mortality-a-primary-care-cohort-study-in-the-united-kingdom
#1
Matthew Hickman, Colin Steer, Kate Tilling, Aaron G Lim, John Marsden, Tim Millar, John Strang, Maggie Telfer, Peter Vickerman, John Macleod
AIMS: To estimate whether opioid substitution treatment (OST) with buprenorphine or methadone is associated with a greater reduction in the risk of all-cause mortality (ACM) and opioid drug-related poisoning (DRP) mortality. DESIGN: Cohort study with linkage between clinical records from Clinical Practice Research Datalink and mortality register. SETTING: UK primary care. PARTICIPANTS: A total of 11 033 opioid-dependent patients who received OST from 1998 to 2014, followed-up for 30 410 person-years...
April 19, 2018: Addiction
https://www.readbyqxmd.com/read/29671080/-lutetium-177-psma-radioligand-therapy-consensus-within-the-framework-of-gkv-funded-care-between-the-university-hospitals-in-aachen-bonn-d%C3%A3-sseldorf-essen-and-cologne-and-the-mdk-nordrhein
#2
REVIEW
H Ahmadzadehfar, P Albers, A Bockisch, M Boegemann, C Böhme, W Burchert, M Dietlein, A Drzezga, U Fabry, G Feldmann, A Heidenreich, A Heinzel, K Herrmann, A Heyll, C Höhling, C Kreuzer, D Laufer, R Mengel, F M Mottaghy, H-W Müller, S C Müller, E Ost, K Rahbar, W Reifenhäuser, M Schäfers, C Schlenkhoff, M Schmidt, I Schmidt-Wolf, C Wildenhain, B Zimmer, M Essler
In the last 3 years, Lutetium-177 prostate-specific membrane antigen radioligand therapy (Lu-177-PSMA-RLT) has received increasing attention in nuclear medicine as a new form of treatment for castration-resistant metastatic prostate cancer. This therapy combines the radionuclide Lutetium-177, which has been therapeutically used in nuclear medicine for many years, with a molecular target of the transmembrane prostate-specific membrane antigen expressed by prostate cancer cells. Since there are no prospective randomized studies on Lu-177-PSMA-RLT and the question of reimbursement has repeatedly been the subject of review by the MDK Nordrhein (Medischenische Dienst der Krankenversicherung), there was a desire because of the increasing number of patients being treated to clarify under which circumstances Lu-177-PSMA-RLT can be reimbursed by German statutory health insurance...
April 18, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29659773/gut-barrier-dysfunction-a-primary-defect-in-twins-with-crohn-s-disease-predominantly-caused-by-genetic-predisposition
#3
Åsa V Keita, Mårten Carl Lindqvist, Åke Öst, Carlos D L Magana, Ida Schoultz, Jonas Halfvarson
Background and aims: The aetiology of Crohn's disease is poorly understood. By investigating twin pairs discordant for Crohn's disease we aimed to assess if the dysregulated barrier represents a cause or a consequence of inflammation and to evaluate the impact of genetic predisposition on barrier function. Methods: Ileal biopsies from 15 twin pairs discordant for Crohn's disease (monozygotic n=9, dizygotic n=6) and 10 external controls were mounted in Ussing chambers to assess paracellular permeability to51Chromium (Cr)-EDTA and trancellular passage to non-pathogenic E...
April 12, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29652897/oxidative-stress-and-antioxidant-defense-responses-in-acartia-copepods-in-relation-to-environmental-factors
#4
Olivier Glippa, Jonna Engström-Öst, Mirella Kanerva, Anni Rein, Kristiina Vuori
On a daily basis, planktonic organisms migrate vertically and thus experience widely varying conditions in their physico-chemical environment. In the Gulf of Finland, these changes are larger than values predicted by climate change scenarios predicted for the next century (up to 0.5 units in pH and 5°C in temperature). In this work, we are interested in how temporal variations in physico-chemical characteristics of the water column on a daily and weekly scale influence oxidative stress level and antioxidant responses in the planktonic copepod of the genus Acartia...
2018: PloS One
https://www.readbyqxmd.com/read/29617602/contagion-and-public-health-in-switzerland-wilhelm-ost-md-1853-1922-polizeiarzt
#5
Lukas Fenner, Kathrin Zürcher, Matthias Egger
No abstract text is available yet for this article.
May 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29610962/are-clinical-guidelines-designed-according-to-guidelines-cross-sectional-assessment-of-quality-and-transparency-of-clinical-guidelines-in-urology
#6
Roderick C N van den Bergh, Piet Ost, Christian Surcel, Massimo Valerio, Jurgen J Fütterer, Giorgio Gandaglia, Prasanna Sooriakumaran, Derya Tilki, Igor Tsaur, Guillaume Ploussard
PURPOSE: Guidelines and recommendations become increasingly important in clinical urologic practice. This study aims to inform clinicians using guidelines on how to evaluate the quality of the methodology and transparency of these documents. METHODS: The guidelines on management of castration-resistant prostate cancer of the American Urology Association, European Association of Urology, National Comprehensive Cancer Network, National Institute for Health and Care Excellence, European Society of Medical Oncology were reviewed using the AGREE-II tool (Appraisal of Guidelines for Research and Evaluation)...
April 2, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29601892/susceptibility-of-brazilian-influenza-a-h1n1-pdm09-viruses-to-neuraminidase-inhibitors-in-the-2014-2016-seasons-identification-of-strains-bearing-mutations-associated-with-reduced-inhibition-profile
#7
Aline R Matos, Paola C Resende, Milene D Miranda, Cristiana C Garcia, Braulia C Caetano, Jonathan C O Lopes, Maria C Debur, Ana L F Cury, Lucas A Vianna, Magliones C Lima, Marcelo Schirmer, Larissa Gubareva, Aeron C Hurt, David W Brown, Marilda M Siqueira
Neuraminidase inhibitors (NAIs) are the main class of antivirals currently used for the treatment of influenza infections. As influenza viruses are constantly evolving, drug-resistance can emerge resulting in reduced effectiveness of treatment. This study evaluated the presence of molecular markers associated with NAI susceptibility in 724 influenza A(H1N1)pdm09 positive samples from Brazilian surveillance system from the 2014-2016 seasons, including 76 isolates tested for oseltamivir (OST) susceptibility and 23 isolates also tested for zanamivir, peramivir and laninamivir susceptibility...
March 27, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29594179/intervention-packages-to-reduce-the-impact-of-hiv-and-hcv-infections-among-people-who-inject-drugs-in-eastern-europe-and-central-asia-a-modeling-and-cost-effectiveness-study
#8
Guillaume Mabileau, Otilia Scutelniciuc, Maia Tsereteli, Ivan Konorazov, Alla Yelizaryeva, Svetlana Popovici, Karimov Saifuddin, Elena Losina, Manoela Manova, Vinay Saldanha, Jean-Elie Malkin, Yazdan Yazdanpanah
Background: We evaluated the effectiveness and cost-effectiveness of interventions targeting hepatitis C virus (HCV) and HIV infections among people who inject drugs (PWID) in Eastern Europe/Central Asia. We specifically considered the needle-syringe program (NSP), opioid substitution therapy (OST), HCV and HIV diagnosis, antiretroviral therapy (ART), and/or new HCV treatment (direct acting antiviral [DAA]) in Belarus, Georgia, Kazakhstan, Republic of Moldova, and Tajikistan. Methods: We developed a deterministic dynamic compartmental model and evaluated the number of infections averted, costs, and incremental cost-effectiveness ratios (ICERs) of interventions...
March 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29581526/hdac-genes-play-distinct-and-redundant-roles-in-cryptococcus-neoformans-virulence
#9
Fabiana Brandão, Shannon K Esher, Kyla S Ost, Kaila Pianalto, Connie B Nichols, Larissa Fernandes, Anamélia L Bocca, Marcio José Poças-Fonseca, J Andrew Alspaugh
The human fungal pathogen Cryptococcus neoformans undergoes many phenotypic changes to promote its survival in specific ecological niches and inside the host. To explore the role of chromatin remodeling on the expression of virulence-related traits, we identified and deleted seven genes encoding predicted class I/II histone deacetylases (HDACs) in the C. neoformans genome. These studies demonstrated that individual HDACs control non-identical but overlapping cellular processes associated with virulence, including thermotolerance, capsule formation, melanin synthesis, protease activity and cell wall integrity...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29572947/metabolic-perturbations-in-welsh-ponies-with-insulin-dysregulation-obesity-and-laminitis
#10
Sarah I Jacob, Kevin J Murray, Aaron K Rendahl, Raymond J Geor, Nichol E Schultz, Molly E McCue
BACKGROUND: Metabolomics, the study of small-molecule metabolites, has increased understanding of human metabolic diseases, but has not been used to study equine metabolic syndrome (EMS). OBJECTIVES: (1) To examine the serum metabolome of Welsh Ponies with and without insulin dysregulation before and during an oral sugar test (OST). (2) To identify differences in metabolites in ponies with insulin dysregulation, obesity, or history of laminitis. ANIMALS: Twenty Welsh Ponies (mean ± SD; 13...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29570899/out-of-school-time-and-behaviors-during-adolescence
#11
Kenneth T H Lee, Ryan W Lewis, Sabrina Kataoka, Katerina Schenke, Deborah L Vandell
Although adolescents experience an array of out-of-school time (OST) settings, research has primarily focused on these settings in isolation. This study examined time in four OST settings (unsupervised time with peers, paid employment, sports, and nonsports organized activities) in relation to adolescent functioning at age 15 and the end of high school. Individual fixed effects analyses provided a more rigorous control of selection into OST activities by controlling for time-invariant observable and unobservable characteristics...
March 23, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29558957/prognostic-value-of-metformin-for-non-small-cell-lung-cancer-patients-with-diabetes
#12
Tongbai Xu, Dongsheng Li, Yuan He, Fuliang Zhang, Man Qiao, Yanhua Chen
BACKGROUND: The anti-cancer role of metformin has been reported in many different kinds of solid tumors, but how it affects non-small cell lung cancer (NSCLC) is currently elusive. The aim of this study was to investigate the influence of metformin treatment on diabetic NSCLC. METHODS: Two hundred fifty-five patients of diabetic NSCLC receiving therapy in our hospital from 2014 to 2016 were enrolled in our study. The information on clinical diagnosis, pathology, and prognosis as well as the influence of metformin in diabetic NSCLC were collected and assessed...
March 20, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29556677/a-feasibility-study-on-adaptive-18-f-fdg-pet-guided-radiotherapy-for-recurrent-and-second-primary-head-and-neck-cancer-in-the-previously-irradiated-territory
#13
Julie Schatteman, Dirk Van Gestel, Dieter Berwouts, Werner De Gersem, Geert De Kerf, Wilfried De Neve, Bie De Ost, Ana Maria Luiza Olteanu, Sylvie Rottey, Tom Vercauteren, Ingeborg Goethals, Fréderic Duprez
PURPOSE: To evaluate feasibility, disease control, survival, and toxicity after adaptive 18 F-fluorodeoxyglucose (FDG) positron emisson tomography (PET) guided radiotherapy in patients with recurrent and second primary head and neck squamous cell carcinoma. METHODS: A prospective trial investigated the feasibility of adaptive intensity modulated radiotherapy (IMRT) ± concomitant cetuximab in 10 patients. The primary endpoint was achieving a 2-year survival free of grade >3 toxicity in ≥30% of patients...
March 19, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29546806/microscopic-colitis-in-patients-with-ulcerative-colitis-or-crohn-s-disease-a-retrospective-observational-study-and-review-of-the-literature
#14
Anna Wickbom, Johan Bohr, Nils Nyhlin, Anders Eriksson, Annika Lapidus, Andreas Münch, Kjell-Arne Ung, Lina Vigren, Åke Öst, Curt Tysk
OBJECTIVES: Onset of microscopic colitis (MC) in patients with ulcerative colitis (UC) or Crohn's disease (CD), or vice versa, has been reported occasionally but the subject is not well described. We therefore report a retrospective observational study of such patients and review the literature. METHODS: Forty-six Swedish gastroenterology clinics were contacted about patients with diagnoses of both inflammatory bowel disease (IBD) and MC. Publications were searched on PubMed...
March 16, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29544737/more-extensive-lymph-node-dissection-at-radical-prostatectomy-is-associated-with-improved-outcomes-with-salvage-radiotherapy-for-rising-prostate-specific-antigen-after-surgery-a-long-term-multi-institutional-analysis
#15
Nicola Fossati, William P Parker, R Jeffrey Karnes, Michele Colicchia, Alberto Bossi, Thomas Seisen, Nadia Di Muzio, Cesare Cozzarini, Barbara Noris Chiorda, Claudio Fiorino, Giorgio Gandaglia, Detlef Bartkowiak, Thomas Wiegel, Shahrokh Shariat, Gregor Goldner, Antonino Battaglia, Steven Joniau, Karin Haustermans, Gert De Meerleer, Valérie Fonteyne, Piet Ost, Hein Van Poppel, Francesco Montorsi, Alberto Briganti, Stephen A Boorjian
Up to 50% of patients recur after salvage radiation therapy (sRT) for prostate-specific antigen (PSA) rise following radical prostatectomy (RP). Notably, the importance of lymph node dissection (LND) at the time of RP with regard to recurrence risk following sRT has not been previously determined. Therefore, we evaluated the association between nodal yield at RP and recurrence after sRT. We performed a multi-institutional review of men with a rising PSA after RP treated with sRT. Clinicopathologic variables were abstracted, and the associations between lymph node yield and biochemical (BCR) as well as clinical recurrence (CR) after sRT were assessed using multivariable Cox proportional hazards regression models...
March 12, 2018: European Urology
https://www.readbyqxmd.com/read/29543164/hysar-hybrid-material-rendering-by-an-optical-see-through-head-mounted-display-with-spatial-augmented-reality-projection
#16
Takumi Hamasaki, Yuta Itoh, Yuichi Hiroi, Daisuke Iwai, Maki Sugimoto
Spatial augmented reality (SAR) pursues realism in rendering materials and objects. To advance this goal, we propose a hybrid SAR (HySAR) that combines a projector with optical see-through head-mounted displays (OST-HMD). In an ordinary SAR scenario with co-located viewers, the viewers perceive the same virtual material on physical surfaces. In general, the material consists of two components: a view-independent (VI) component such as diffuse reflection, and a view-dependent (VD) component such as specular reflection...
April 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29538079/update-on-airway-stents
#17
Bruce F Sabath, David E Ost
PURPOSE OF REVIEW: The current review describes the latest evidence regarding the use of stents for malignant airway obstruction. RECENT FINDINGS: Therapeutic bronchoscopy, including stenting, can restore patency in up to 93% of patients with malignant central airway obstruction. The patients that benefit the most are those with worse baseline dyspnea, higher American Society of Anesthesiology score, poorer functional status, and central obstruction (rather than lobar)...
March 13, 2018: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/29536236/a-novel-image-processing-procedure-for-thermographic-image-analysis
#18
Sara Matteoli, Davide Coppini, Andrea Corvi
The imaging procedure shown in this paper has been developed for processing thermographic images, measuring the ocular surface temperature (OST) and visualizing the ocular thermal maps in a fast, reliable, and reproducible way. The strength of this new method is that the measured OSTs do not depend on the ocular geometry; hence, it is possible to compare the ocular profiles belonging to the same subject (right and left eye) as well as to different populations. In this paper, the developed procedure is applied on two subjects' eyes: a healthy case and another affected by an ocular malignant lesion...
March 14, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29534645/the-effects-of-co-witness-discussion-on-confidence-and-precision-in-eyewitness-memory-reports
#19
Joanne Rechdan, Lorraine Hope, James D Sauer, Melanie Sauerland, James Ost, Harald Merckelbach
We examined the influence of co-witness discussion on the metacognitive regulation of memory reports. Participants (N = 92) watched a crime video. Later, a confederate confidently agreed with (gave confirming feedback), disagreed with (gave disconfirming feedback), or gave no feedback (control) regarding participants' answers to questions about the video. Participants who received disconfirming feedback reported fewer fine-grain details than participants in the confirming and control conditions on a subsequent, individual recall test for a different question set...
March 13, 2018: Memory
https://www.readbyqxmd.com/read/29530632/standard-of-care-versus-metastases-directed-therapy-for-pet-detected-nodal-oligorecurrent-prostate-cancer-following-multimodality-treatment-a-multi-institutional-case-control-study
#20
T Steuber, C Jilg, P Tennstedt, A De Bruycker, D Tilki, K Decaestecker, T Zilli, B A Jereczek-Fossa, U Wetterauer, A L Grosu, W Schultze-Seemann, H Heinzer, M Graefen, A Morlacco, R J Karnes, P Ost
BACKGROUND: Most prostate cancer (PCa) patients with a biochemical failure following primary multimodality treatment (surgery and postoperative radiotherapy) relapse in the nodes. OBJECTIVE: To perform a matched-case analysis in men with lymph node recurrent PCa comparing standard of care (SOC) with metastasis-directed therapy (MDT). DESIGN, SETTING, AND PARTICIPANTS: PCa patients with a prostate-specific antigen (PSA) progression following multimodality treatment were included in this retrospective multi-institutional analysis...
March 10, 2018: European Urology Focus
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