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https://www.readbyqxmd.com/read/28221727/docetaxel-bevacizumab-and-gemcitabine-for-very-high-risk-sarcomas-in-adolescents-and-young-adults-a-single-center-experience
#1
Christopher Kuo, Paul M Kent, Antonio D Logan, Karen B Tamulonis, Kristen L Dalton, Marta Batus, Karen Fernandez, Rebecca E Mcfall
BACKGROUND: Adolescent and young adult (AYA) patients with very high risk sarcomas have poor outcomes and are in need of novel therapies. PROCEDURE: From January 2005 to February 2016, we retrospectively identified all AYA patients with relapsed or metastatic high-grade sarcomas, who were treated with at least one cycle of docetaxel (T), bevacizumab (A), and gemcitabine (G) (TAG ; T = 100 mg/m(2) Day 8, A = 15 mg/kg Day 1, G = 1,000 mg/m(2) Days 1 and 8). RESULTS: Fourteen patients, median age of 20 (15-30), received a total of 80 cycles of TAG, and were followed for a median of 83 months...
April 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28205325/wholegrain-oat-diet-changes-the-expression-of-genes-associated-with-intestinal-bile-acid-transport
#2
Kristina E Andersson, Aakash Chawade, Narda Thuresson, Ana Rascon, Rickard Öste, Olov Sterner, Olof Olsson, Per Hellstrand
SCOPE: The molecular mechanisms underlying the cholesterol-lowering properties of oats are only partly known. To study possible pathways involved, we investigated gene expressions in the liver and small intestine of mice fed oats. METHOD AND RESULTS: Cholesterol and bile acids were analysed in plasma and faeces from LDL-receptor deficient (LDLr(-/-) ) mice fed Western diet with wholegrain oats. A transcriptome analysis of mRNA from liver and jejunum was performed together with quantitative RT-PCR...
February 16, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28198975/short-term-sodium-alendronate-administration-improves-the-peri-implant-bone-quality-in-osteoporotic-animals
#3
Danila de Oliveira, Jaqueline Suemi Hassumi, Pedro Henrique da Silva Gomes-Ferreira, Tárik Ocon Braga Polo, Gabriel Ramalho Ferreira, Leonardo Perez Faverani, Roberta Okamoto
Objective: The aim of this study was to evaluate the bone repair process at the bone/implant interface of osteoporotic rats treated with sodium alendronate through the analysis of microtomography, real time polymerase chain reactions and immunohistochemistry (RUNX2 protein, bone sialoprotein (BSP), alkaline phosphatase, osteopontin and osteocalcin). Material and Methods: A total of 42 rats were used and divided in to the following experimental groups: CTL: control group (rats submitted to fictitious surgery and fed with a balanced diet), OST: osteoporosis group (rats submitted to a bilateral ovariectomy and fed with a low calcium diet) and ALE: alendronate group (rats submitted to a bilateral ovariectomy, fed with a low calcium diet and treated with sodium alendronate)...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28185875/salvage-stereotactic-body-radiotherapy-for-isolated-lymph-node-recurrent-prostate-cancer-single-institution-series-of-94-consecutive-patients-and-124-lymph-nodes
#4
Barbara Alicja Jereczek-Fossa, Giuseppe Fanetti, Cristiana Fodor, Delia Ciardo, Luigi Santoro, Claudia Maria Francia, Matteo Muto, Alessia Surgo, Dario Zerini, Giulia Marvaso, Giorgia Timon, Paola Romanelli, Elena Rondi, Stefania Comi, Federica Cattani, Federica Golino, Stefano Mazza, Deliu Victor Matei, Matteo Ferro, Gennaro Musi, Franco Nolè, Ottavio de Cobelli, Piet Ost, Roberto Orecchia
BACKGROUND: The purpose of the study was to evaluate the prostate serum antigen (PSA) response, local control, progression-free survival (PFS), and toxicity of stereotactic body radiotherapy (SBRT) for lymph node (LN) oligorecurrent prostate cancer. PATIENTS AND METHODS: Between May 2012 and October 2015, 124 lesions were treated in 94 patients with a median dose of 24 Gy in 3 fractions. Seventy patients were treated for a single lesion and 25 for > 1 lesion...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28173632/impact-of-the-choices-intervention-in-preventing-alcohol-exposed-pregnancies-in-american-indian-women
#5
Jessica D Hanson, Morgan E Nelson, Jamie L Jensen, Amy Willman, Jacque Jacobs-Knight, Karen Ingersoll
BACKGROUND: Fetal Alcohol Spectrum Disorders (FASD) comprise a continuum of lifelong outcomes in those born prenatally exposed to alcohol. Although studies have shown no differences in rates by race, FASD is of particular concern for American Indian communities. One tribally-run prevention program is the Oglala Sioux Tribe (OST) CHOICES Program, which is modeled after the evidence-based CHOICES program that was focused on preconceptional prevention of alcohol-exposed pregnancy (AEP) by reducing risky drinking in women at-risk for pregnancy and/or preventing unintended pregnancy...
February 7, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28163369/misrepresentations-and-flawed-logic-about-the-prevalence-of-false-memories
#6
Robert A Nash, Kimberley A Wade, Maryanne Garry, Elizabeth F Loftus, James Ost
Brewin and Andrews (2016) propose that just 15% of people, or even fewer, are susceptible to false childhood memories. If this figure were true, then false memories would still be a serious problem. But the figure is higher than 15%. False memories occur even after a few short and low-pressure interviews, and with each successive interview, they become richer, more compelling, and more likely to occur. It is therefore dangerously misleading to claim that the scientific data provide an "upper bound" on susceptibility to memory errors...
January 2017: Applied Cognitive Psychology
https://www.readbyqxmd.com/read/28160345/does-exposure-to-opioid-substitution-treatment-in-prison-reduce-the-risk-of-death-after-release-a-national-prospective-observational-study-in-england
#7
John Marsden, Garry Stillwell, Hayley Jones, Alisha Cooper, Brian Eastwood, Michael Farrell, Tim Lowden, Nino Maddalena, Chris Metcalfe, Jenny Shaw, Matthew Hickman
BACKGROUND AND AIMS: People with opioid use disorder (OUD) in prison face an acute risk of death after release. We estimated whether prison-based opioid substitution treatment (OST) reduces this risk. DESIGN: Prospective observational cohort study using prison healthcare, national community drug misuse treatment and deaths registers. SETTING: Recruitment at 39 adult prisons in England (32 male; 7 female) accounting for 95% of OST treatment in England during study planning...
February 4, 2017: Addiction
https://www.readbyqxmd.com/read/28160325/impact-of-osteoblast-maturation-on-their-paracrine-growth-enhancing-activity-on-cord-blood-progenitors
#8
Manal Alsheikh, Ahmad Abu-Khader, Matthew Michalicka, Roya Pasha, Nicolas Pineault
BACKGROUND: Osteoblasts possess strong growth modulatory activity on hematopoietic stem cells and progenitors. We sought to characterise the growth and differentiation modulatory activities of human osteoblasts at distinct stages of maturation on cord blood (CB) progenitors in the context of osteoblast conditioned medium (OCM). METHODS: OCM was produced from MSC-derived osteoblasts (M-OST) at distinct stages of maturation. The growth modulatory activities of the OCM were tested on CB CD34(+) cells using different functional assays...
February 3, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28157599/harm-beliefs-and-coping-expectancies-in-youth-with-specific-phobias
#9
Thomas H Ollendick, Lars-Göran Öst, Sarah M Ryan, Nicole N Capriola, Lena Reuterskiöld
Catastrophic beliefs and lowered coping expectancies are often present in individuals with specific phobias (SPs). The current study examined these beliefs and expectancies in 251 youth who received One Session Treatment for one of the three most common types of SP in youth (animals, natural environment, and situational). We compared the children's subjective beliefs to objective ratings of the likelihood of occurrence and the dangerousness of the feared events. Results revealed pre-treatment differences in the youths' beliefs across phobia types and age...
January 18, 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28153420/the-independent-oncological-role-for-cytoreductive-nephrectomy-in-metastatic-renal-cell-carcinoma-prognostic-features-in-the-era-of-targeted-therapies
#10
Tom Claeys, Nicolaas Lumen, Candy Kumps, Marleen Praet, Gert De Meerleer, Sylvie Rottey, Piet Ost, Pieter Devisschere, Geert Villeirs, Valerie Fonteyne, Karel Decaestecker
OBJECTIVES: To describe the effects of cytoreductive nephrectomy (CN) on the natural course of metastatic renal cell carcinoma (mRCC). CN appears to stabilize metastatic lesions in mRCC in a subgroup of patients and we hypothesize that systemic treatment might be deferred in these patients with stable disease after CN. SUBJECTS AND METHODS: Overall, 45 patients with mRCC who underwent CN and subsequent oncologic follow-up were included in this retrospective, single-center analysis...
January 30, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28146373/osthole-inhibited-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-emt-by-suppressing-nf-%C3%AE%C2%BAb-mediated-snail-activation-in-lung-cancer-a549-cells
#11
Haitao Feng, Jin-Jian Lu, Yitao Wang, Lixia Pei, Xiuping Chen
Epithelial-mesenchymal transition (EMT), the transdifferentiation of epithelial cells into mesenchymal cells, has been implicated in the metastasis and provides novel strategies for cancer therapy. Osthole (OST), a dominant active constituent of Chinese herb Cnidium monnieri, has been reported to inhibit cancer metastasis while the mechanisms remains unclear. Here, we studied the inhibitory effect and mechanisms of OST on TGF-β1-induced EMT in A549 cells. Cells were treated with TGF-β1 in the absence and presence of OST...
February 1, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28143983/rim-pathway-mediated-alterations-in-the-fungal-cell-wall-influence-immune-recognition-and-inflammation
#12
Kyla S Ost, Shannon K Esher, Chrissy M Leopold Wager, Louise Walker, Jeanette Wagener, Carol Munro, Floyd L Wormley, J Andrew Alspaugh
: Compared to other fungal pathogens, Cryptococcus neoformans is particularly adept at avoiding detection by innate immune cells. To explore fungal cellular features involved in immune avoidance, we characterized cell surface changes of the C. neoformans rim101Δ mutant, a strain that fails to organize and shield immunogenic epitopes from host detection. These cell surface changes are associated with an exaggerated, detrimental inflammatory response in mouse models of infection. We determined that the disorganized strain rim101Δ cell wall increases macrophage detection in a contact-dependent manner...
January 31, 2017: MBio
https://www.readbyqxmd.com/read/28140617/progressive-consent-and-specimen-accrual-models-to-address-sustainability-a-decade-s-experience-at-an-oregon-biorepository
#13
John A Ost, Paul W Newton, Duncan R Neilson, Joseph A Cioffi, P Ashley Wackym, R Serene Perkins
BACKGROUND: The Legacy Biorepository is a College of American Pathologists-accredited biorepository operating within a seven-hospital healthcare system, with a decade's experience in specimen accrual, storage, and distribution. While standardization of our practices through accreditation remains a priority, we along with others face challenges with regard to sustainability. Purposeful changes in our consent process, which we term "progressive consent," are expected to improve sustainability and operational flexibility while increasing our scientific impact...
February 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/28137295/a-phase-ii-trial-of-stereotactic-body-radiotherapy-with-concurrent-anti-pd1-treatment-in-metastatic-melanoma-evaluation-of-clinical-and-immunologic-response
#14
Katrien De Wolf, Vibeke Kruse, Nora Sundahl, Mireille van Gele, Ines Chevolet, Reinhart Speeckaert, Lieve Brochez, Piet Ost
BACKGROUND: Antibodies blocking programmed cell death 1 (PD-1) have encouraging responses in patients with metastatic melanoma. Response to anti-PD-1 treatment requires pre-existing CD8+ T cells that are negatively regulated by PD-1-mediated adaptive immune resistance. Unfortunately, less than half of melanoma tumours have these characteristics. Combining anti-PD-1 treatment with other immunomodulating treatments to activate CD8+ T cells is therefore of vital importance to increase response rates and long-term survival benefit in melanoma patients...
January 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28129761/snacks-beverages-and-physical-activity-during-volunteer-led-out-of-school-time-programs-a-cross-sectional-analysis
#15
Christina D Economos, Stephanie Anzman-Frasca, Alyssa H Koomas, Grace Chan, Sara C Folta, Julianne Heck, Molly Newman, Jennifer M Sacheck
BACKGROUND: Tens of millions of children regularly participate in out-of-school-time (OST) programs, providing an opportunity for child health promotion. Most research on OST has focused on structured, staff-led after-school programs, as opposed to volunteer-led programs such as enrichment programs and youth sports. The aim of this study was to describe snacks, beverages, and physical activity (PA) practices in volunteer-led OST programs across five organizations in three states. METHODS: An online survey including the Out-of-School-Time Snacks, Beverages, and Physical Activity Questionnaire was distributed to 1,695 adult leaders of enrichment and youth sports programs serving 5-12 year-old children in Maine, Massachusetts, and New Hampshire, USA...
January 27, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28124536/a-prospective-randomized-controlled-multicentre-trial-comparing-intravesical-dmso-and-chondro%C3%A3-tin-sulphate-2-for-painful-bladder-syndrome-interstitial-cystitis
#16
Manuela Tutolo, Enrico Ammirati, Giulia Castagna, Katrien Klockaerts, Hendrik Plancke, Dieter Ost, Frank Van der Aa, Dirk De Ridder
OBJECTIVE: To compare effectiveness of intravesical chondroïtin sulphate (CS) 2% and dimethyl sulphoxide (DMSO) 50% in patients with painful bladder syndrome/interstitial cystitis (PBS/IC). MATERIALS AND METHODS: Patients were randomized to receive either 6 weekly instillations of CS 2% or 50% DMSO. Primary endpoint was difference in proportion of patients achieving score 6 (moderately improved) or 7 (markedly improved) in both groups using the Global Response Assessment (GRA) scale...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28123752/mediterranean-style-diet-is-associated-with-low-risk-of-new-onset-diabetes-after-renal-transplantation
#17
Maryse C J Osté, Eva Corpeleijn, Gerjan J Navis, Charlotte A Keyzer, Sabita S Soedamah-Muthu, Else van den Berg, Douwe Postmus, Martin H de Borst, Daan Kromhout, Stephan J L Bakker
OBJECTIVE: The incidence of new-onset diabetes after transplantation (NODAT) and premature mortality is high in renal transplant recipients (RTR). We hypothesized that a Mediterranean Style diet protects against NODAT and premature mortality in RTR. RESEARCH DESIGN AND METHODS: A prospective cohort study of adult RTR with a functioning graft for >1 year. Dietary intake was assessed with a 177-item validated food frequency questionnaire. Patients were divided based on a 9-point Mediterranean Style Diet Score (MDS): low MDS (0-4 points) versus high MDS (5-9 points)...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28112560/evaluating-stone-free-status-following-percutaneous-stone-procedures-in-patients-with-spina-bifida-do-anatomical-factors-play-a-role
#18
Rajeev Chaudhry, Katherine Theisen, Heidi Stephany, Francis Schneck, Glenn Cannon, Michael C Ost
PURPOSE: Percutaneous stone surgery can be challenging in spina bifida (SB) patients due to their body habitus and spinal cord anomalies. A safe surgical approach may necessitate acceptance of lower stone-free rates. We seek to determine if anatomic complexity, as measured by spinal cord curvature and torso length, is associated with stone-free rates after percutaneous stone surgery in SB patients. We hypothesize that increasing anatomic complexity is associated with lower stone-free rates following percutaneous stone surgery...
January 23, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28111491/the-value-of-life-in-english-law-revered-but-not-sacred
#19
Rob Heywood, Alexandra Mullock
Terms such as sanctity and inviolability have failed to provide a legally coherent or ethically sound principle upon which to determine the scope of the intrinsic value of life against extrinsic, quality-of-life considerations in a medical context. In their recent work, Margaret Brazier and Suzanne Ost introduce a new term, reverence for life, which they suggest may be more appropriate when attempting to navigate the murky waters of the meaning of life and the value that should be attached to it. They suggest that reverence should be utilised as an alternative that better reflects the nuances and the realities of the dilemma...
December 2016: Legal Studies: the Journal of the Society of Legal Scholars
https://www.readbyqxmd.com/read/28106833/influence-of-temperature-on-transdermal-penetration-enhancing-mechanism-of-borneol-a-multi-scale-study
#20
Qianqian Yin, Ran Wang, Shufang Yang, Zhimin Wu, Shujuan Guo, Xingxing Dai, Yanjiang Qiao, Xinyuan Shi
The influence of temperature on the transdermal permeation enhancing mechanism of borneol (BO) was investigated using a multi-scale method, containing a coarse-grained molecular dynamic (CG-MD) simulation, an in vitro permeation experiment, and a transmission electron microscope (TEM) study. The results showed that BO has the potential to be used as a transdermal penetration enhancer to help osthole (OST) penetrate into the bilayer. With the increasing temperature, the stratum corneum (SC) becomes more flexible, proving to be synergistic with the permeation enhancement of BO, and the lag time (TLag) of BO and OST are shortened...
January 19, 2017: International Journal of Molecular Sciences
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