keyword
MENU ▼
Read by QxMD icon Read
search

Validity and reliability

keyword
https://www.readbyqxmd.com/read/28938618/beclin-1-and-lc3-as-predictive-biomarkers-for-metastatic-colorectal-carcinoma
#1
Hong Zhao, Maopeng Yang, Bin Zhao
Autophagy is a highly conserved self-destructive process that disassembles dysfunctional or unnecessary cellular components. It plays an important role in cancer metastasis, which is of particular interest considering metastatic disease is the major cause of colorectal carcinoma (CRC) related mortality. Here, we investigated the immunohistochemical expression of autophagy-related protein Beclin 1 and Microtubule-associated protein 1A/1B-light chain 3 (LC3) within surgical CRC specimens, first in a training cohort (205 patients), then in an inner validation cohort (160 patients) and an independent cohort (161 patients)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938580/diagnostic-significance-of-urinary-long-non-coding-pca3-rna-in-prostate-cancer
#2
Tao Wang, Xiangyun Qu, Jiajia Jiang, Peng Gao, Dingding Zhao, Xueqi Lian, Xiaohua Li
Prostate cancer antigen 3(PCA3) is a long non-coding RNA, which was found increased expression in CaP patients than healthy individual. In this study, the individual nucleic acid of PCA3 and PSA was recombinant expressed as a reference reagent, and a quantitative RT-PCR with TaqMan assay was developed to examine the copies of PCA3 and PSA gene in urine. The results showed that the area under the receiver operating characteristic curve (AUROC) was 0.717, 0.444 and 0.916 for the number of PCA3 copy, PSA copy and for the score of PCA3/PSA RNA, respectively...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938490/expression-of-contactin-4-is-associated-with-malignant-behavior-in-pheochromocytomas-and-paragangliomas
#3
Lucie Evenepoel, Francien H van Nederveen, Lindsey Oudijk, Thomas G Papathomas, David F Restuccia, Eric J T Belt, Wouter W de Herder, Richard A Feelders, Gaston J H Franssen, Marc Hamoir, Dominique Maiter, Aurel Perren, Henri J L M Timmers, Susanne van Eeden, Laurent Vroonen, Selda Aydin, Mercedes Robledo, Miikka Vikkula, Ronald R de Krijger, Winand N M Dinjens, Alexandre Persu, Esther Korpershoek
Context: Pheochromocytomas and paragangliomas (PPGL) are rare neuroendocrine, usually benign tumors. Currently, the only reliable criterion of malignancy is the presence of metastases. Objective: The aim was to identify genes associated with malignancy in PPGL. Design: Transcriptomic profiling was performed on 40 benign and 11 malignant PPGL. Genes showing a significantly different expression between benign and malignant PPGL with a ratio ≥ 4 were confirmed, and subsequently tested in an independent series by qRT-PCR...
August 17, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938284/longitudinal-validation-of-the-promis-physical-function-item-bank-in-upper-extremity-trauma
#4
Aaron J Kaat, Nan E Rothrock, Mark S Vrahas, Robert V OʼToole, Sarah K Buono, Timothy Zerhusen, Richard C Gershon
OBJECTIVES: To evaluate the reliability, validity, and responsiveness of the Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity Computer Adaptive Test (UE-CAT) and the 8-item Physical Function short form (PF-SF8a) for monitoring outcomes after musculoskeletal injuries in upper extremity trauma patients. DESIGN: Prospective cohort study. SETTING: Two Level-I trauma centers. PATIENTS: Eligible consecutive patients were approached and 424 consented at time 1 (median 9...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938147/development-of-an-experimental-model-of-burst-fracture-with-damage-characterization-of-the-vertebral-bodies-under-dynamic-conditions
#5
A Germaneau, T Vendeuvre, M Saget, P Doumalin, J C Dupré, F Brémand, F Hesser, C Brèque, P Maxy, M Roulaud, O Monlezun, P Rigoard
BACKGROUND: Burst fractures represent a significant proportion of fractures of the thoracolumbar junction. The recent advent of minimally invasive techniques has revolutionized the surgical treatment of this type of fracture. However mechanical behaviour and primary stability offered by these solutions have to be proved from experimental validation tests on cadaveric specimens. Therefore, the aim of this study was to develop an original and reproducible model of burst fracture under dynamic impact...
September 13, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28938106/assessment-of-a-specifically-developed-bullet-casing-gun-for-the-stunning-of-water-buffaloes
#6
Carmen Meichtry, Urs Glauser, Matthieu Glardon, Steffen G Ross, Isabel Lechner, Beat P Kneubuehl, Dominic Gascho, Claudia Spadavecchia, Alois von Rotz, Ana Stojiljkovic, Michael H Stoffel
Water buffaloes and cattle differ considerably with respect to the anatomy of the head. As a result, captive bolt stunners often fail to reliably produce adequate loss of consciousness in water buffaloes and, thus, do not fulfill animal welfare requirements. The goal of the present study was to assess and validate a new stunning device for water buffaloes meeting animal welfare and occupational safety requirements. The newly designed bullet casing gun uses .357Mag/10.2g hollow point bullets and has additional safety features...
September 14, 2017: Meat Science
https://www.readbyqxmd.com/read/28937632/design-and-analysis-of-a-low-latency-deterministic-network-mac-for-wireless-sensor-networks
#7
Prasan Kumar Sahoo, Sudhir Ranjan Pattanaik, Shih-Lin Wu
The IEEE 802.15.4e standard has four different superframe structures for different applications. Use of a low latency deterministic network (LLDN) superframe for the wireless sensor network is one of them, which can operate in a star topology. In this paper, a new channel access mechanism for IEEE 802.15.4e-based LLDN shared slots is proposed, and analytical models are designed based on this channel access mechanism. A prediction model is designed to estimate the possible number of retransmission slots based on the number of failed transmissions...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937460/utility-of-the-surgical-apgar-score-for-patients-who-undergo-surgery-for-spinal-metastasis
#8
Darryl Lau, Timothy J Yee, Frank La Marca, Rakesh Patel, Paul Park
STUDY DESIGN: Retrospective review of patients who underwent surgery for spinal metastasis between 2005 and 2011. OBJECTIVE: To assess the utility of the surgical Apgar score (SAS) in patients who underwent surgery for spinal metastasis. SUMMARY OF BACKGROUND DATA: Surgery for spinal metastasis can be associated with relatively high morbidity and mortality. Consequently, identifying patients at risk for major postoperative complications is important...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28937298/probing-the-toxicity-of-nanoparticles-a-unified-in-silico-machine-learning-model-based-on-perturbation-theory
#9
Riccardo Concu, Valeria V Kleandrova, Alejandro Speck-Planche, M Natália D S Cordeiro
Nanoparticles (NPs) are part of our daily life, having a wide range of applications in engineering, physics, chemistry, and biomedicine. However, there are serious concerns regarding the harmful effects that NPs can cause to the different biological systems and their ecosystems. Toxicity testing is an essential step for assessing the potential risks of the NPs, but the experimental assays are often very expensive and usually too slow to flag the number of NPs that may cause adverse effects. In silico models centered on quantitative structure-activity/toxicity relationships (QSAR/QSTR) are alternative tools that have become valuable supports to risk assessment, rationalizing the search for safer NPs...
September 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28937285/assessment-of-automatic-segmentation%C3%A2-of-teeth-using%C3%A2-a-watershed-based-method
#10
Antoine Galibourg, Jean Dumoncel, Norbert Telmon, Adèle Calvet, Jérôme Michetti, Delphine Maret
OBJECTIVES: Tooth 3D automatic segmentation (AS) is being actively developed in research and clinical fields. Here, we assess the effect of automatic segmentation using a watershed-based method on the accuracy and reproducibility of 3D reconstructions in volumetric measurements by comparing it with a semi-automatic (SAS) method that has already been validated. METHODS: The study sample comprised 52 teeth, scanned with micro computed tomography (micro CT) (41µm voxel size) and cone beam computed tomography (CBCT) (76 ; 200 and 300 µm voxel size)...
September 21, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28937059/the-effect-of-an-educational-program-for-vascular-access-care-on-nurses-knowledge-at-dialysis-centers-in-khartoum-state-sudan
#11
Kalthoum Ibrahim Yousif, Hasan Abu-Aisha, Omar Ibrahim Abboud
End-stage renal disease is a worldwide problem that requires highly skilled nursing care. Hemodialysis (HD) is a corner-stone procedure in the management of most patients who require renal replacement therapy. Adequate vascular access is essential for the successful use of HD. Appropriate knowledge in taking care of vascular access is essential for minimizing complications and accurately recognizing vascular access-related problems. This study was to evaluate the effect of an educational program for vascular access care on nurses' knowledge at nine dialysis centers in Khartoum State...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937032/development-and-standardization-of-a-new-cognitive-assessment-test-battery-for-chinese-aphasic-patients-a-preliminary-study
#12
Ji-Bao Wu, Zhi-Hong Lyu, Xiao-Jia Liu, Hai-Peng Li, Qi Wang
BACKGROUND: Nonlinguistic cognitive impairment has become an important issue for aphasic patients, but currently there are few neuropsychological cognitive assessment tests for it. To get more information on cognitive impairment of aphasic patients, this study aimed to develop a new cognitive assessment test battery for aphasic patients, the Non-language-based Cognitive Assessment (NLCA), and evaluate its utility in Chinese-speaking patients with aphasia. METHODS: The NLCA consists of five nonverbal tests, which could assess five nonlinguistic cognitive domains such as visuospatial functions, attention test, memory, reasoning, and executive functions of aphasic patients...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28936913/evaluation-of-complete-blood-count-indices-nlr-plr-mpv-plt-and-plcri-in-healthy-dogs-dogs-with-periodontitis-and-dogs-with-oropharyngeal-tumors-as-potential-biomarkers-of-systemic-inflammatory-response
#13
Ana Rejec, Janos Butinar, Jerzy Gawor, Milan Petelin
The aim of the study was to retrospectively assess complete blood count (CBC) indices of dogs with periodontitis (PD; n = 73) and dogs with oropharyngeal tumors (OT; n = 92) in comparison to CBC indices of healthy dogs (HD; n = 71). Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio, mean platelet volume to platelet ratio, and platelet large cell ratio index (PLCRi) were evaluated as biomarkers of systemic inflammatory response provoked by PD and OT. Results of multivariable polytomous logistic regression analysis indicated no significant associations between CBC indices and PD...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28936819/-the-scope-quality-and-safety-requirements-of-drug-abuse-testing
#14
Tuncay Küme, Çiğdem Karakükcü, Aslı Pınar, Hakan Coşkunol
The aim of this review is to inform about the scopes and requirements of drug abuse testing. Drug abuse testing is one of the tools for determination of drug use. It must fulfill the quality and safety requirements in judgmental legal and administrative decisions. Drug abuse testing must fulfill some requirements like selection of the appropriate test matrix, appropriate screening test panel, sampling in detection window, patient consent, identification of the donor, appropriate collection site, sample collection with observation, identification and control of the sample, specimen custody chain in preanalytical phase; analysis in authorized laboratories, specimen validity tests, reliable testing METHODS, strict quality control, two-step analysis in analytical phase; storage of the split specimen, confirmation of the split specimen in the objection, result custody chain, appropriate cut-off concentration, the appropriate interpretation of the result in postanalytical phase...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936818/-measuring-grief-symptoms-in-cancer-patients-the-reliability-and-validity-study-of-the-turkish-version-of-prolonged-grief-disorder-scale
#15
Ilgın Gökler Danışman, Merve Yalçınay, Nejla Yıldız
OBJECTIVE: The need to grieve is not limited to losses due to death of significant others, but it also arises in reaction to various life events which result in a sense of loss. Grief is argued to be a universal and natural reaction also in face of life-theratening illnesses. Cancer is a phenomenon that has to be examined in terms of grief reactions since it inherits multiple losses. The aim of the current study is to test the reliability and validity of the Turkish version of Prolonged Grief Disorder Scale-Patient Form (PG-12-Patient Form), which is used to measure grief symptoms in cancer patients...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936605/sex-determination-of-a-tunisian-population-by-ct-scan-analysis-of-the-skull
#16
Malek Zaafrane, Mehdi Ben Khelil, Ines Naccache, Ekbel Ezzedine, Frédéric Savall, Norbert Telmon, Najla Mnif, Moncef Hamdoun
It is widely accepted that the estimation of biological attributes in the human skeleton is more accurate when population-specific standards are applied. With the shortage of such data for contemporary North African populations, it is duly required to establish population-specific standards. We present here the first craniometric standards for sex determination of a contemporary Tunisian population. The aim of this study was to analyze the correlation between sex and metric parameters of the skull in this population using CT scan analysis and to generate proper reliable standards for sex determination of a complete or fragmented skull...
September 21, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28936412/test-retest-reliability-and-construct-validity-of-the-aspects-of-wheelchair-mobility-test-as-a-measure-of-the-mobility-of-wheelchair-users
#17
Karen L Rispin, Kara Huff, Joy Wee
BACKGROUND: The Aspects of Wheelchair Mobility Test (AWMT) was developed for use in a repeated measures format to provide comparative effectiveness data on mobility facilitated by different wheelchair types. It has been used in preliminary studies to compare the mobility of wheelchairs designed for low-resource areas and is intended to be simple and flexible enough so as to be used in low-technology settings. However, to reliably compare the impact of different types of wheelchairs on the mobility of users, a measure must first be a reliable and valid measure of mobility...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/28936370/military-families-perceptions-of-neighborhood-characteristics-affecting-reintegration-development-of-an-aggregate-measure
#18
Sarah Beehler, Jennifer Ahern, Brandi Balmer, Jennifer Kuhlman
This pilot study evaluated the validity and reliability of an Experience of Neighborhood (EON) measure developed to assess neighborhood characteristics that shape reintegration opportunities for returning service members and their families. A total of 91 post-9/11 veterans and spouses completed a survey administered at the Minnesota State Fair. Participants self-reported on their reintegration status (veterans), social functioning (spouses), social support, and mental health. EON factor structure, internal consistency reliability, and validity (discriminant, content, criterion) were analyzed...
2017: Military Behavioral Health
https://www.readbyqxmd.com/read/28936189/psychometric-properties-of-language-assessments-for-children-aged-4-12-years-a-systematic-review
#19
Deborah Denman, Renée Speyer, Natalie Munro, Wendy M Pearce, Yu-Wei Chen, Reinie Cordier
Introduction: Standardized assessments are widely used by speech pathologists in clinical and research settings to evaluate the language abilities of school-aged children and inform decisions about diagnosis, eligibility for services and intervention. Given the significance of these decisions, it is important that assessments have sound psychometric properties. Objective: The aim of this systematic review was to examine the psychometric quality of currently available comprehensive language assessments for school-aged children and identify assessments with the best evidence for use...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28936136/older-adults-preferences-for-formal-social-support-of-autonomy-and-dependence-in-pain-development-and-validation-of-a-scale
#20
Sónia F Bernardes, Marta Matos, Liesbet Goubert
Chronic pain among older adults is common and often disabling. Pain-related formal social support (e.g., provided by staff at day-care centers, nursing homes), and the extent to which it promotes functional autonomy or dependence, plays a significant role in the promotion of older adults' ability to engage in their daily activities. Assessing older adults' preferences for pain-related social support for functional autonomy or dependence could contribute to increase formal social support responsiveness to individuals' needs...
September 2017: European Journal of Ageing
keyword
keyword
49694
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"