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"Anxiety" and "depression"

Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We determined the association between any common mental disorder (CMD: depression, anxiety disorder, bipolar disorder) and mortality and suicide in three immune-mediated inflammatory diseases (IMID), inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA), versus age-, sex- and geographically-matched controls. METHODS: Using administrative data, we identified 28,384 IMID cases (IBD: 8695; MS: 5496; RA: 14,503) and 141,672 matched controls...
June 7, 2018: General Hospital Psychiatry
Carolyn W Swenson, Neil S Kamdar, Kristian Seiler, Daniel M Morgan, Paul Lin, Sawsan As-Sanie
BACKGROUND: Opioids used for postoperative pain control after surgery have been associated with an increased risk of chronic opioid use. Hysterectomy is the most common major gynecologic procedure in the United States; however, we lack a data-driven definition of new persistent opioid use specific to hysterectomy. OBJECTIVE: 1) Determine a data-driven definition of new persistent opioid use among opioid naïve women undergoing hysterectomy; 2) Determine the prevalence of and risk factors for new persistent opioid use...
June 18, 2018: American Journal of Obstetrics and Gynecology
Pınar Duru, Mine Esin Ocaktan, Ümit Çelen, Özlem Örsal
Background: The aims of this study were to determine the extent of workplace bullying perceptions among the employees of a Faculty of Medicine, evaluating the variables considered to be associated, and determining the effect of workplace bullying perceptions on their psychological symptoms evaluated by the Brief Symptom Inventory (BSI). Methods: This cross-sectional study was performed involving 355 (88.75%) employees. Results: Levels of perceived workplace bullying were found to increase with the increasing scores for BSI and BSI sub-dimensions of anxiety, depression, negative self, somatization, and hostility (all p  < 0...
June 2018: Safety and Health At Work
Roya Abolfazli, Shirin Pournourmohammadi, Ahmadreza Shamshiri, Sara Samadzadeh
Background: The aim of this study was to evaluate the safety, tolerability, and efficacy of a brand-generic glatiramer acetate product in patients with relapsing-remitting multiple sclerosis over a 12-month period. A noninterventional cohort study was conducted on 185 patients. The patients had a confirmed and documented diagnosis of relapsing-remitting multiple sclerosis as defined by the Revised McDonald Criteria (2010), were ambulatory with a Kurtzke Expanded Disability Status Scale score of 0 to 5...
2018: Current Therapeutic Research, Clinical and Experimental
Dusan Kolar
Treatment-resistant mood disorders and anxiety disorders require intensive treatment, but treatment options should balance benefits and adverse effects or other potential detrimental effects on patients, including the risk of developing prescription medication addiction. Some of the newer treatment modalities for mood and anxiety disorders may have similar properties to benzodiazepines. The goal of this review was to identify the potential for developing dependence on the novel treatment approaches to treatment-resistant depression and refractory anxiety disorders...
2018: Neuropsychiatric Disease and Treatment
Alain Chamoux, Céline Lambert, Audrey Vilmant, Charlotte Lanhers, Raymond Agius, Mounir Boutaleb, Vincent Bonneterre, Geraldine Naughton, Bruno Pereira, Khalid Djeriri, Eric Ben-Brik, Christine Breton, Caroline De Clavière, Corinne Letheux, Anne-Gaëlle Paolillo, Madeleine Valenty, Odile Vandenberghe, Marie-Pierre Aeschlimann, Gérard Lasfargues, Francois-Xavier Lesage, Frédéric Dutheil
BACKGROUND: Mental disorders in the workplace are a major public health problem. Knowledge of the impact of the psychosocial work environment on mental and behavioral disorders can assist occupational physicians in the identification and description of occupational risk situations, and help to define priority actions. However, no classification for occupational exposure factors is currently available. We aimed to build a thesaurus of "Organizational, Relational, Ethical and other Contributing Factors" (FOREC) linked with the onset of mental and behavioral disorders...
2018: PloS One
Ji Hyun Baek, Kiwon Kim, Jin Pyo Hong, Maeng Je Cho, Maurizio Fava, David Mischoulon, Sung Man Chang, Ji Yeon Kim, Hana Cho, Hong Jin Jeon
Eating disorders comorbid with depression are an established risk factor for suicide. In this study, we aimed to determine the effects of binge eating (BE) symptoms on suicidality and related clinical characteristics in major depressive disorder (MDD). A total of 817 community participants with MDD were included. We compared two groups (with and without lifetime BE symptoms). The MDD with BE group was subdivided into a frequent BE (FBE) subgroup (BE symptoms greater than twice weekly) and any BE (ABE) subgroup (BE symptoms greater than twice weekly)...
2018: PloS One
G P Ivanova, L N Gorobets, A V Litvinov, V S Bulanov, L M Vasilenko
The review presents literature data reflecting the nature and mechanism of the effect of progesterone and its metabolites on human and animal brain structures. Particular attention is paid to neuroprotective, anticonvulsant, anti-anxiety and sedative properties of this hormone, which determines the prospect of its use for the prevention and treatment of human neurodegenerative diseases, epilepsy, sleep disorders, and anxiety-depressive spectrum disorders, including premenstrual and climacteric syndromes.
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
John E Pachankis, Timothy J Sullivan, Nora F Moore
While existing research documents the impact of parental rejection on sexual minorities, the present study extends this research to include a subtler, yet potentially more pervasive, challenge facing sexual minorities and their parents, with lasting implications for mental health. Parental unfinished business refers to persistent, unresolved negative thoughts and feelings toward one's parents and is investigated here as a result of parental rejection of their sexual minority sons' sexual orientation. To capture developmental trajectories of parental unfinished business and its prospective predictors (i...
June 21, 2018: Journal of Family Psychology: JFP
Steven A Safren, Aaron J Blashill, Jasper S Lee, Conall O'Cleirigh, Julia Tomassili, Katie B Biello, Matthew J Mimiaga, Kenneth H Mayer
OBJECTIVE: Among men who have sex with men (MSM), HIV sexual risk and poor self-care behavior is associated with syndemics, or co-occurring psychosocial problems. Though prior research has demonstrated an additive total effect of syndemics on HIV risk behavior and infection, mostly within cross-sectional designs, it is possible that these associations are not direct but rather that syndemics disrupt relevant individual-level mediating psychological variables. One of the more common individual-level psychological variables that predicts health behavior generally, and HIV risk behavior specifically, is self-efficacy...
June 21, 2018: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Femke Jansen, Irma M Verdonck-de Leeuw, Pim Cuijpers, C René Leemans, Tim Waterboer, Michael Pawlita, Chris Penfold, Steven J Thomas, Andrea Waylen, Andrew R Ness
OBJECTIVE: To investigated the relation between pre-treatment depressive symptoms (DS) and the course of DS during the first year after cancer diagnosis, and overall survival among people with head and neck cancer (HNC). METHODS: Data from the Head and Neck 5000 prospective clinical cohort study were used. DS were measured using the Hospital Anxiety and Depression Scale (HADS) pre-treatment, at 4 and 12 months follow-up. Also socio-demographic, clinical, lifestyle and mortality data were collected...
June 21, 2018: Psycho-oncology
Shuang Li, Wen-Qing Yao, Ye-Zheng Tao, Lan Ma, Xing Liu
Serotonin (5-hydroxtryptamine, 5-HT), one of the central neurotransmitters, is the most important modulator for emotion regulation, sensory processing, cognitive control, etc. The serotonergic neurons are limited in amount and mainly distributed in the dorsal raphe nucleus (DR) and the median raphe nucleus (MR) in the midline of the brain stem. Previous studies mainly focused on the function of 5-HT neurons in the DR, but little is known about 5-HT neurons in MR. In the present study, with Pet1-Cre transgenic mice and DREADDs technology, we specifically activated or silenced 5-HT neurons in the MR, and aimed to explore their roles in anxiety- and depressive-like behaviors...
June 25, 2018: Sheng Li Xue Bao: [Acta Physiologica Sinica]
Alberta Engelbrecht, Howard Burdett, Maria João Silva, Kamaldeep Bhui, Edgar Jones
BACKGROUND: UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS: A standardised form was used to collect data from pension records of a random sample of 500 UK army veterans from the first presentation in the 1940s until 1980...
June 21, 2018: Psychological Medicine
Jiabao Pan, Bingjie Liu, Gary L Kreps
BACKGROUND: Depression is a mood disorder that may lead to severe outcomes including mental breakdown, self-injury, and suicide. Potential causes of depression include genetic, sociocultural, and individual-level factors. However, public understandings of depression guided by a complex interplay of media and other societal discourses might not be congruent with the scientific knowledge. Misunderstandings of depression can lead to under-treatment and stigmatization of depression. Against this backdrop, this study aims to achieve a holistic understanding of the patterns and dynamics in discourses about depression from various information sources in China by looking at related posts on social media...
June 20, 2018: BMC Public Health
J Reginald Fils-Aimé, David J Grelotti, Tatiana Thérosmé, Bonnie N Kaiser, Giuseppe Raviola, Yoldie Alcindor, Jennifer Severe, Emmeline Affricot, Katherine Boyd, Rupinder Legha, Shin Daimyo, Stephanie Engel, Eddy Eustache
This study evaluates the use of a mental health mobile clinic to overcome two major challenges to the provision of mental healthcare in resource-limited settings: the shortage of trained specialists; and the need to improve access to safe, effective, and culturally sound care in community settings. Employing task-shifting and supervision, mental healthcare was largely delivered by trained, non-specialist health workers instead of specialists. A retrospective chart review of 318 unduplicated patients assessed and treated during the mobile clinic's first two years (January 2012 to November 2013) was conducted to explore outcomes...
2018: PloS One
Jonathan H Hsu, Benoit H Mulsant, Eric J Lenze, Marcos Sanches, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger
OBJECTIVE: Augmentation with aripiprazole is an effective pharmacotherapy for treatment-resistant late-life depression (LLD). However, aripiprazole can cause extrapyramidal symptoms (EPS) such as akathisia and parkinsonism; these symptoms are distressing and can contribute to treatment discontinuation. We investigated the clinical trajectories and predictors of akathisia and parkinsonism in older patients receiving aripiprazole augmentation for treatment-resistant LLD. METHODS: Between 2009 and 2013, depressed older adults who did not remit with venlafaxine were randomized to aripiprazole or placebo in a 12-week trial...
June 19, 2018: Journal of Clinical Psychiatry
Elizabeth K Seng, Alexander J Kuka, Sarah Jo Mayson, Todd A Smitherman, Dawn C Buse
OBJECTIVE: To evaluate relationships between psychiatric symptoms, acceptance, and migraine-related disability in a sample of people with migraine presenting at a tertiary care headache center. BACKGROUND: Migraine is a chronic disease that can be severely disabling. Despite a strong theoretical basis and evidence in other pain conditions, little is known about relationships between acceptance, psychiatric symptoms, and migraine-related disability. METHODS: Ninety patients with physician-diagnosed migraine completed surveys assessing demographics, headache symptoms, severe migraine-related disability (Migraine Disability Assessment Scale total score dichotomized at ≥ 21), depression (Patient Health Questionnaire-9) and anxiety symptoms (Generalized Anxiety Disorder-7), and acceptance (Chronic Pain Acceptance Questionnaire; subscales: Pain Willingness and Activity Engagement)...
June 2018: Headache
Cynthia Y Huang, Ron Daniels, Angie Lembo, Christiane Hartog, Jim O'Brien, Thomas Heymann, Konrad Reinhart, H Bryant Nguyen
Objective: In this study, we aim to describe the post-sepsis syndrome from the perspective of the sepsis survivors. Design and Setting: The study is a prospective, observational online international survey. Participants: Sepsis survivors enrolled via social media from 13 September 2014 to 13 September 2016. Interventions: None. Main Outcome Measures: Physiologic, physical and psychological function post-sepsis; and patient satisfaction with sepsis-centered care...
June 19, 2018: International Journal for Quality in Health Care
Åsa Askim, Lise Tuset Gustad, Julie Paulsen, Solveig Klæbo Reitan, Arne Mehl, Randi Marie Mohus, Andrew Dewan, Jan Kristian Damås, Erik Solligård, Bjørn Olav Åsvold
OBJECTIVE: We examined whether anxiety and depression symptoms constitute increased risk of bloodstream infection (BSI), as a proxy for sepsis. METHODS: A general population with self-reported anxiety and depression symptoms was followed prospectively for hospital-verified BSI. Using multivariable Cox regression analysis, we estimated hazard ratios (HR) with 95% confidence intervals (CI) of BSI and BSI mortality, with and without statistical adjustment for comorbidities, BMI and lifestyle factors that may confound or mediate the associations...
June 19, 2018: Psychosomatic Medicine
Song Wang, Yajun Zhao, Bochao Cheng, Xiuli Wang, Xun Yang, Taolin Chen, Xueling Suo, Qiyong Gong
As a hot research topic in the field of psychology and psychiatry, trait optimism reflects the tendency to expect positive outcomes in the future. Consistent evidence has demonstrated the role of trait optimism in reducing anxiety among different populations. However, less is known about the neural bases of trait optimism and the underlying mechanisms for how trait optimism protects against anxiety in the healthy brain. In this investigation, we examined these issues in 231 healthy adolescent students by assessing resting-state brain activity (i...
June 19, 2018: Human Brain Mapping
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