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Anemia in HI

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https://www.readbyqxmd.com/read/27824902/efficacy-and-safety-of-lenalidomide-for-treatment-of-low-intermediate-1-risk-myelodysplastic-syndromes-with-or-without-5q-deletion-a-systematic-review-and-meta-analysis
#1
Xin-Yue Lian, Zhi-Hui Zhang, Zhao-Qun Deng, Pin-Fang He, Dong-Ming Yao, Zi-Jun Xu, Xiang-Mei Wen, Lei Yang, Jiang Lin, Jun Qian
BACKGROUND: Lenalidomide could effectively induce red blood cell (RBC) transfusion independence (TI) in patients with lower-risk (Low/Intermediate-1) myelodysplastic syndrome (MDS) with or without 5q deletion. However whether lenalidomide ultimately improves the overall survival (OS) of lower-risk MDS patients and reduces the progression to AML remains controversial. METHOD: A meta-analysis was conducted to examine the efficacy and safety of lenalidomide in the treatment of lower-risk MDS...
2016: PloS One
https://www.readbyqxmd.com/read/27602087/insights-into-the-role-of-iron-in-immature-rat-model-of-hypoxic-ischemic-brain-injury
#2
Zi-Wei Wang, Li-Jun Yang, Ying-Xue Ding, Yan-Zhong Chang, Hong Cui
This study aimed to investigate the role of iron in the occurrence and development of hypoxic-ischemic brain injury (HIBI) in immature rat models using 3-day-old Sprague Dawley rats. Normal control (NC), hypoxic-ischemic (HI), anemia, HI + ischemia, early iron treatment and late iron treatment groups were established. Rat brain tissue sections were stained with hematoxylin and eosin and pathologically evaluated. Iron content and mRNA expression levels of iron regulatory protein 2 (IRP2) and transferrin receptor in the brain tissues were measured...
September 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27281795/deep-phenotyping-of-tregs-identifies-an-immune-signature-for-idiopathic-aplastic-anemia-and-predicts-response-to-treatment
#3
Shahram Kordasti, Benedetta Costantini, Thomas Seidl, Pilar Perez Abellan, Marc Martinez Llordella, Donal McLornan, Kirsten E Diggins, Austin Kulasekararaj, Cinzia Benfatto, Xingmin Feng, Alexander Smith, Syed A Mian, Rossella Melchiotti, Emanuele de Rinaldis, Richard Ellis, Nedyalko Petrov, Giovanni A M Povoleri, Sun Sook Chung, N Shaun B Thomas, Farzin Farzaneh, Jonathan M Irish, Susanne Heck, Neal S Young, Judith C W Marsh, Ghulam J Mufti
Idiopathic aplastic anemia (AA) is an immune-mediated and serious form of bone marrow failure. Akin to other autoimmune diseases, we have previously shown that in AA regulatory T cells (Tregs) are reduced in number and function. The aim of this study was to further characterize Treg subpopulations in AA and investigate the potential correlation between specific Treg subsets and response to immunosuppressive therapy (IST) as well as their in vitro expandability for potential clinical use. Using mass cytometry and an unbiased multidimensional analytical approach, we identified 2 specific human Treg subpopulations (Treg A and Treg B) with distinct phenotypes, gene expression, expandability, and function...
September 1, 2016: Blood
https://www.readbyqxmd.com/read/26632468/-long-term-outcome-of-thalidomide-and-cyclosporine-in-patients-with-ipss-low-intermediate-1-myelodysplastic-syndromes
#4
Jingya Wang, Tiejun Qin, Zefeng Xu, Yue Zhang, Hongli Zhang, Liwei Fang, Lijuan Pan, Naibo Hu, Shiqiang Qu, Bing Li, Zhijian Xiao
OBJECTIVE: To investigate the long- term outcome of cyclosporin A (CsA) combined with thalidomide regime for Chinese patients with IPSS low/intermediate- 1 myelodysplastic syndromes (MDS) without del(5q)and the predictive variables which could impact the response to the therapy. METHODS: Seventy-six MDS patients who were treated with these drugs at a single institute in China were retrospectively analyzed. The polymorphism of cereblon gene, rs1672753, was detected in patients of this cohort by PCR and direct sequencing...
November 2015: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/26484089/transcriptome-analysis-of-rpl11-deficient-zebrafish-model-of-diamond-blackfan-anemia
#5
Zhaojun Zhang, Haibo Jia, Qian Zhang, Yang Wan, Binfeng Song, Qiong Jia, Hanzhi Liu, Xiaofan Zhu, Xiangdong Fang
To comprehensively reflect the roles of Rpl11 on the transcriptome of zebrafish model of Diamond-Blackfan Anemia (DBA), we performed whole-genome transcriptome sequencing on the Illumina Hi-Seq 2000 sequencing platform. Two different transcriptomes of zebrafish Rpl11-deficient and control Morpholino (Mo) embryos were collected and analyzed. The experimental design and methods, including sample preparation, RNA-Seq data evaluation and treatment, were described in details so that representative high-throughput sequencing data were acquired for assessing the actual impacts of Rpl11 on zebrafish embryos...
December 2014: Genomics Data
https://www.readbyqxmd.com/read/26415558/a-two-step-haploidentical-versus-a-two-step-matched-related-allogeneic-myeloablative-peripheral-blood-stem-cell%C3%A2-transplantation
#6
COMPARATIVE STUDY
Sameh Gaballa, Neil Palmisiano, Onder Alpdogan, Matthew Carabasi, Joanne Filicko-O'Hara, Margaret Kasner, Walter K Kraft, Benjamin Leiby, Ubaldo Martinez-Outschoorn, William O'Hara, Barbara Pro, Shannon Rudolph, Manish Sharma, John L Wagner, Mark Weiss, Neal Flomenberg, Dolores Grosso
Haploidentical stem cell transplantation (SCT) offers a transplantation option to patients who lack an HLA-matched donor. We developed a 2-step approach to myeloablative allogeneic hematopoietic stem cell transplantation for patients with haploidentical or matched related (MR) donors. In this approach, the lymphoid and myeloid portions of the graft are administered in 2 separate steps to allow fixed T cell dosing. Cyclophosphamide is used for T cell tolerization. Given a uniform conditioning regimen, graft T cell dose, and graft-versus-host disease (GVHD) prophylaxis strategy, we compared immune reconstitution and clinical outcomes in patients undergoing 2-step haploidentical versus 2-step MR SCT...
January 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/25918650/durable-red-blood-cell-transfusion-independence-in-a-patient-with-an-mds-mpn-overlap-syndrome-following-discontinuation-of-iron-chelation-therapy
#7
Harpreet Kochhar, Chantal S Leger, Heather A Leitch
Background. Hematologic improvement (HI) occurs in some patients with acquired anemias and transfusional iron overload receiving iron chelation therapy (ICT) but there is little information on transfusion status after stopping chelation. Case Report. A patient with low IPSS risk RARS-T evolved to myelofibrosis developed a regular red blood cell (RBC) transfusion requirement. There was no response to a six-month course of study medication or to erythropoietin for three months. At 27 months of transfusion dependence, she started deferasirox and within 6 weeks became RBC transfusion independent, with the hemoglobin normalizing by 10 weeks of chelation...
2015: Case Reports in Hematology
https://www.readbyqxmd.com/read/25784172/involvement-of-interleukin-21-in-the-pathophysiology-of-aplastic-anemia
#8
Jizhou Zhang, Qingqing Wu, Jun Shi, Meili Ge, Xingxin Li, Yingqi Shao, Jianfeng Yao, Yizhou Zheng
OBJECTIVE: Recently enhanced T-helper type 17 (Th17) immune responses and deficient CD4(+) CD25(hi) FoxP3(+) regulatory T cells (Tregs) have been reported in acquired aplastic anemia (AA). Interleukin-21 (IL-21), a CD4(+) T-cell-derived proinflammatory cytokine, modulates the balance between Th17 cells and Tregs. However, its role in AA remains unclear. METHODS: IL-21 gene expression was examined by quantitative real-time PCR. Cytokines in plasma and cell culture supernatants were detected by ELISA...
July 2015: European Journal of Haematology
https://www.readbyqxmd.com/read/25709889/progressive-transfusion-and-growth-factor-independence-with-adjuvant-sertraline-in-low-risk-myelodysplastic-syndrome-treated-with-an-erythropoiesis-stimulating-agent-and-granulocyte-colony-stimulating-factor
#9
Kirtan Nautiyal, Rui Li, Sarvari Yellapragada, Perumal Thiagarajan, Martha Mims, Gustavo Rivero
Refractoriness to growth factor therapy is commonly associated with inferior outcome in patients with low-risk myelodysplastic syndrome (LR-MDS) who require treatment for cytopenias. However, the mechanisms leading to refractoriness are unknown. Here we describe a clinically depressed 74-year-old male with refractory cytopenia with multilineage dysplasia (RCMD) and documented growth factor refractory anemia after erythropoeisis stimulating agent (ESA) therapy, who attained transfusion and growth factor independence after the addition of sertraline to his medication regimen...
2015: Leukemia Research Reports
https://www.readbyqxmd.com/read/25216792/effects-of-different-doses-and-duration-of-iron-supplementation-on-curing-iron-deficiency-anemia-an-experimental-study
#10
Juan Ma, Xiaosha Wen, Fengfeng Mo, Xiaoli Wang, Zhilei Shen, Min Li
Many controversies persist with respect to the dosage and therapeutic duration concerning iron deficiency anemia (IDA) treatment. To identify the most suitable cure, this study evaluated the effect of iron supplementation with different doses and for different time periods in rats with iron deficiency anemia. The rats were randomly divided into five groups [normal control (NC), low- iron diet control (LC), normal doses of iron group (NI), middle dose of iron group (MI), and high dose of iron group (HI)]. Each group was subdivided into two subgroups (2 and 4 weeks)...
December 2014: Biological Trace Element Research
https://www.readbyqxmd.com/read/24969821/recombinant-human-erythropoietin-augments-angiogenic-responses-in-a-neonatal-rat-model-of-cerebral-unilateral-hypoxia-ischemia
#11
Lihua Zhu, Xiang Bai, Shiyu Wang, Yan Hu, Ting Wang, Lijuan Qian, Li Jiang
BACKGROUND: Recombinant human erythropoietin (rh-EPO) has been used as a drug to treat premature infant anemia for over a decade. In addition to its erythropoietic effect, rh-EPO has also been reported to have protective effects against brain injury. OBJECTIVES: Our aim was to evaluate the levels of angiogenesis-related cells (CD34+ cells) and angiogenic factors (vascular endothelial growth factor, VEGF, and angiopoietin-1, Ang-1) in a neonatal rat model of cerebral unilateral hypoxia-ischemia (HI) and to identify the effects of rh-EPO on angiogenic responses...
2014: Neonatology
https://www.readbyqxmd.com/read/24763008/-peripheral-blood-lymphocyte-subsets-and-their-relation-with-early-response-to-treatment-in-patients-with-low-or-intermediate-risk-myelodysplastic-syndrome-ipss-score-%C3%A2-1-0-and-chronic-aplastic-anemia
#12
Meng-Ying Zhang, Jie Ma, Hui Sun, Xin-Sheng Xie, Chong Wang, Shuai Liu, Tao Li
The purpose of this study was retrospectively to analyze the peripheral blood lymphocyte subset distribution in patients with low or intermediate risk myelodysplastic syndromes (IPSS ≤ 1.0) and chronic aplastic anemia (CAA), and their hematological changes of peripheral blood after treatment, so as to understand differences and their relation with early treatment response. The lymphocyte subsets in peripheral blood of 67 patient with low or intermediate risk MDS (IPSS ≤ 1.0), 54 patients with CAA and 73 healthy individuals were analyzed by flow cytometry...
April 2014: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/24746590/frailty-in-older-persons-multisystem-risk-factors-and-the-frailty-risk-index-fri
#13
Tze Pin Ng, Liang Feng, Ma Shwe Zin Nyunt, Anis Larbi, Keng Bee Yap
IMPORTANCE: Currently there is no risk factor scale that identifies older persons at risk of frailty. OBJECTIVES: In this study, we identified significant multisystem risk factors of frailty, developed a simple frailty risk index, and evaluated it for use in primary care on an external validation cohort of community-living older persons. DESIGN, SETTING, AND PARTICIPANTS: We used cross-sectional data of 1685 older adults aged 55 and older in the Singapore Longitudinal Ageing Studies (SLAS) to identify 13 salient risk factors among 40 known and putative risk factors of the frailty phenotype (weakness, slowness, low physical activity, weight loss, and exhaustion)...
September 2014: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/24672190/study-of-addiction-problems-and-morbidity-among-geriatric-population-in-rural-area-of-aurangabad-district
#14
Vinod Mundada, Vijay Jadhav, A V Gaikwad
RESEARCH QUESTION: What is the addiction problems and morbidity profile pattern of geriatric population in rural area? OBJECTIVES: i) To study the morbidity profile of elderly. ii) To study the addiction problems among elderly. MATERIALS AND METHODS: The present study was carried out at the field practice area of Rural Health and Training Center (RHTC), Paithan of Government Medical College, Aurangabad during the period of September 1, 2006 to August 31, 2007...
July 2013: Journal of Mid-life Health
https://www.readbyqxmd.com/read/24602726/-clinical-efficacy-analysis-of-recombinant-human-erythropoietin-in-the-treatment-of-lower-risk-myelodysplastic-syndromes
#15
Hongli Zhang, Tiejun Qin, Zefeng Xu, Liwei Fang, Lijuan Pan, Naibo Hu, Shiqiang Qu, Yue Zhang, Zhijian Xiao
OBJECTIVE: To investigate the efficacy and impact factors in lower-risk [International prognostic scoring system (IPSS) low or intermediate-1 risk] myelodysplastic syndrome (MDS) patients treated with recombinant human erythropoietin (rhEPO) alone or in combination with recombinant human granulocyte colony- stimulating factor (rhG-CSF). METHODS: A total of 52 consecutive lower-risk MDS patients received subcutaneous injection of rhEPO alone or in combination with rhG-CSF at least 8 weeks, the rhEPO dose would be reduced slowly to stop or kept at minimum to maintain the response when the best efficacy achieved and maintained for 4 weeks...
January 2014: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/24378594/mild-maternal-iron-deficiency-anemia-induces-dpoae-suppression-and-cochlear-hair-cell-apoptosis-by-caspase-activation-in-young-guinea-pigs
#16
Fei Yu, Shuai Hao, Yue Zhao, Yahao Ren, Jun Yang, Xiance Sun, Jie Chen
Iron deficiency (ID) anemia (IDA) alters auditory neural normal development in the mammalian cochlea. Previous results suggest that mild maternal IDA during pregnancy and lactation altered the hearing and nervous system development of the young offspring, but the mechanisms underlying the association are incompletely understood. The objective of this study was to evaluate the role of apoptosis in the development of sensory hair cells following mild maternal IDA during pregnancy and lactation. We established a maternal anemia model in female guinea pigs by using a mild iron deficient diet...
January 2014: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/24159174/tropomodulin3-null-mice-are-embryonic-lethal-with-anemia-due-to-impaired-erythroid-terminal-differentiation-in-the-fetal-liver
#17
Zhenhua Sui, Roberta B Nowak, Andrea Bacconi, Nancy E Kim, Hui Liu, Jie Li, Amittha Wickrema, Xiu-li An, Velia M Fowler
Tropomodulin (Tmod) is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types. Targeted deletion of mouse tropomodulin3 (Tmod3) leads to embryonic lethality at E14.5-E18.5, with anemia due to defects in definitive erythropoiesis in the fetal liver. Erythroid burst-forming unit and colony-forming unit numbers are greatly reduced, indicating defects in progenitor populations. Flow cytometry of fetal liver erythroblasts shows that late-stage populations are also decreased, including reduced percentages of enucleated cells...
January 30, 2014: Blood
https://www.readbyqxmd.com/read/23733767/randomized-open-label-phase-ii-study-of-decitabine-in-patients-with-low-or-intermediate-risk-myelodysplastic-syndromes
#18
RANDOMIZED CONTROLLED TRIAL
Guillermo Garcia-Manero, Elias Jabbour, Gautam Borthakur, Stefan Faderl, Zeev Estrov, Hui Yang, Sirisha Maddipoti, Lucy A Godley, Nashat Gabrail, Jesus G Berdeja, Ahmed Nadeem, Laurent Kassalow, Hagop Kantarjian
PURPOSE: This open-label, randomized phase II trial assessed efficacy and tolerability of two low-dose regimens of subcutaneous (SC) decitabine in patients with low- or intermediate-1-risk myelodysplastic syndrome (MDS). PATIENTS AND METHODS: Patients received decitabine 20 mg/m(2) SC per day for 3 consecutive days on days 1, 2, and 3 every 28 days (schedule A) or 20 mg/m(2) SC per day once every 7 days on days 1, 8, and 15 every 28 days (schedule B) for up to 1 year...
July 10, 2013: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/23720018/regulatory-b-cell-compartment-in-transfused-alloimmunized-and-non-alloimmunized-patients-with-sickle-cell-disease
#19
Weili Bao, Hui Zhong, Deepa Manwani, Ljiljana Vasovic, Joan Uehlinger, Margaret T Lee, Sujit Sheth, Patricia Shi, Karina Yazdanbakhsh
Transfusion therapy is a life-sustaining treatment for patients with sickle cell disease (SCD), but can cause serious complications including alloimmunization. We previously reported diminished regulatory T cells (Tregs) and skewed Th2 responses in alloimmunized SCD patients. We hypothesized that the B cell regulatory (Breg) compartment, which controls Treg and Th differentiation, may also be compromised in allosensitized SCD patients. Phenotypically, we did not find differences in the frequency or numbers of CD24(hi) CD38(hi) and CD24(hi) CD27(+) B cell subsets, both previously identified as human Bregs, between alloimmunized and non-alloimmunized SCD patients on regular transfusions...
September 2013: American Journal of Hematology
https://www.readbyqxmd.com/read/23638917/leber-s-congenital-amaurosis-as-the-retinal-degenerative-phenotype-in-thiamine-responsive-megaloblastic-anemia-a-case-report
#20
Natarajan N Srikrupa, Swaminathan Meenakshi, Tharigopala Arokiasamy, Kaushik Murali, Nagasamy Soumittra
BACKGROUND: Thiamine responsive megaloblastic anemia syndrome (TRMA), an autosomal recessive disorder is caused by mutations in the SLC19A2 gene which encodes for thiamine transporter 1 (THTR1) protein. TRMA presents with a triad of clinical features that includes diabetes mellitus, megaloblastic anemia and sensorineural hearing loss. Apart from the triad, reported ophthalmic features include cone rod dystrophy, optic atropy and retinitis pigmentosa. MATERIALS AND METHODS: A female child presented with Leber's congenital amaurosis at 10 months of age, later diagnosed with hearing impairment at 1 year, diabetes mellitus and megaloblastic anemia at 3 and a half years of age and hence as a case of thiamine responsive megaloblastic anemia...
June 2014: Ophthalmic Genetics
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